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1. Circulating Growth Differentiation Factor 15 Is Increased Preceding Preeclampsia Diagnosis: Implications as a Disease Biomarker

Author

Tess Cruickshank, Teresa M. MacDonald, Susan P. Walker, Emerson Keenan, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Jenny Myers, Catherine Cluver, Roxanne Hastie, Lina Bergman, Damanpreet Garcha, Ping Cannon, Elizabeth Murray, Tuong‐Vi Nguyen, Richard Hiscock, Natasha Pritchard, Natalie J. Hannan, Stephen Tong, and Tu’uhevaha J. Kaitu’u‐Lino

Subjects
biomarker, placental growth factor, preeclampsia, pregnancy, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background We investigated the biomarker potential of growth differentiation factor 15 (GDF‐15), a stress response protein highly expressed in placenta, to predict preeclampsia. Methods and Results In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 controls, 41 developed preeclampsia), plasma concentrations of GDF‐15 at 36 weeks' gestation were significantly increased among those who developed preeclampsia (P

Published
2021
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