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2. The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database
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Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Nanchal, R, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, D, Kilminster, M, Sturgess, D, Ziegenfuss, M, O' Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, D'Agostino Dias, M, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Martin-Loeches, I, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, Martos, C, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Haller, A, Matthew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Norton, A, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, Gowda, K, Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Villalba Gaviria M. C., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Juan Francisco L. L., Namendys-Silva S. A., Moya R. G., Hernandez M., Rodriguez Cadena D. M., Islas I. L., Ballesteros Zarzavilla C. M., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Mareque Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal G., Lahkar B., Mandal A. K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, Citerio G, Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Nanchal, R, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, D, Kilminster, M, Sturgess, D, Ziegenfuss, M, O' Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, D'Agostino Dias, M, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Martin-Loeches, I, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, Martos, C, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Haller, A, Matthew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Norton, A, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, Gowda, K, Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Villalba Gaviria M. C., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Juan Francisco L. L., Namendys-Silva S. A., Moya R. G., Hernandez M., Rodriguez Cadena D. M., Islas I. L., Ballesteros Zarzavilla C. M., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Mareque Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal G., Lahkar B., Mandal A. K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, and Citerio G
- Abstract
Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.
- Published
- 2020
3. The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database
- Author
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Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Villalba Gaviria M. C., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Juan Francisco L. L., Namendys-Silva S. A., Moya R. G., Hernandez M., Rodriguez Cadena D. M., Islas I. L., Ballesteros Zarzavilla C. M., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Mareque Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal G., Lahkar B., Mandal A. K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, Citerio G, Université libre de Bruxelles (ULB), Belfast City Hospital, Department Intensive Care Medicine, Center of Infectious Diseases, Radboudumc, Nijmegen, The Netherlands., University of Bern [Bern, Switzerland] (University Hospital Bern ), Universität Augsburg [Augsburg], Prince Sultan university (saudi Arabia), Riyadh, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Assistance Publique - Hôpitaux de Marseille (APHM), Mayo Clinic, Jena University Hospital [Jena], Supporting clinical sciences, Intensive Care, Internal Medicine Specializations, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, UCL - (SLuc) Service de soins intensifs, Vincent, J. -L., Ferguson, A., Pickkers, P., Jakob, S. M., Jaschinski, U., Almekhlafi, G. A., Leone, M., Mokhtari, M., Fontes, L. E., Bauer, P. R., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M. N., Nica, A., Stoica, R., Tomescu, D. R., Constantinescu, D. L., Valcoreanu Zbaganu, G. M., Slavcovici, A., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X. Z., Zhao, X., Li, C. H., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T. H., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Li, C., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W. L., Sin, K. K. C., Lee, K. L., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T. T., Hata, N., Kobe, Y., Nishida, O., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. A. N., Tai, L. L., Tony, B., Bigornia, R. R., Palo, J. E., Chatterjee, S., Tan, B. H., Kong, A., Goh, S., Lee, C. -C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Nowruzinia, S., Lotfi, A. H., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A. Y., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H. K., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J. C., Herridge, M., Fernandez-Medero, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R. G., Jimenez, E., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Hawkins, D. J., Kilminster, M., Sturgess, D., Ziegenfuss, M., O' Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M. M., D'Agostino Dias, M., Lunardi, M. C., Youssef, N. C., Lobo, S., Silva, R., Sales, J. A., Melo, L. M. C., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A. P., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Filho, R. C., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro Castro, L. F., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Villalba Gaviria, M. C., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Juan Francisco, L. L., Namendys-Silva, S. A., Moya, R. G., Hernandez, M., Rodriguez Cadena, D. M., Islas, I. L., Ballesteros Zarzavilla, C. M., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Mareque Gianoni, S. M., Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Von Der Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, G., Lahkar, B., Mandal, A. K., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Zirpe, K., Patel, M., Bhavsar, A., Samaddar, D. P., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K. -H., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Gadisseux, P., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., De Waele, J. J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Spapen, H., Van Collie, O., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V. -P., Saarinen, K., Durocher, A., Moulront, S., Lepape, A., Losser, M. -R., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J. -Y., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Floccard, B., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Lepoivre, T., Moussa, M. D., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C. -J., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R. A., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. G., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S. O., Barry, J., O'Leary, R. A., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., De Oliveira, A. V., Gomes, J., Gaspar, I., Pereira, M. F., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J. J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Martin-Loeches, I., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gonzalez Gallego, M. A., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Perez Granda, M. J., Moreno, S., Llubia, C., Martos, C. D. L. F., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Quindos, B., Quintano, A., Tebar, M. T., Cardinal, P., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J. A., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Matthew, S., Downes, R., Groba, C. B., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Norton, A., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Alexander, P., Henderson, S., Hargreaves, C., Black, H., Gowda, K., Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Nanchal, R, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, D, Kilminster, M, Sturgess, D, Ziegenfuss, M, O' Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, D'Agostino Dias, M, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Martin-Loeches, I, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, Martos, C, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Haller, A, Matthew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Norton, A, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, and Gowda, K
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Male ,umrljivost ,medicine.medical_treatment ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,udc:616.1/.4 ,Critical Care and Intensive Care Medicine ,urologic and male genital diseases ,akutna ledvična odpoved ,renal insufficiency ,law.invention ,0302 clinical medicine ,law ,Oliguria ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,030212 general & internal medicine ,Prospective Studies ,ComputingMilieux_MISCELLANEOUS ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,oligurija ,nadomestno zdravljenje ledvične odpovedi ,Acute Kidney Injury ,Middle Aged ,kidney diseases ,Intensive care unit ,urine ,3. Good health ,urine output ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Mortality, Renal replacement therapy, Urine output ,Female ,oliguria ,medicine.symptom ,renal replacement therapy ,Adult ,kidney ,medicine.medical_specialty ,oskrba kritično bolnih ,urin ,Critical Illness ,610 Medicine & health ,Statistics, Nonparametric ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,acute kidney failure ,medicine ,critical illness ,Humans ,Clinical significance ,In patient ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,ddc:610 ,Renal replacement therapy ,izločanje urina ,Mortality ,Urine output ,Aged ,Observational database ,Analysis of Variance ,Critically ill ,business.industry ,Research ,renalna insuficienca ,Médecine pathologie humaine ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,mortality ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,critical care ,bolezni ledvic ,Emergency medicine ,kritično stanje ,ledvica ,business - Abstract
BackgroundUrine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis.ResultsOf the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient—oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged—oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent—oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19–1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97–1.34], p = 0.103).ConclusionsOliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome., 0, info:eu-repo/semantics/published
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- 2019
4. A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit
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Kotfis, K., Wittebole, X., Jaschinski, U., Sole-Violan, J., Kashyap, R., Leone, M., Nanchal, R., Fontes, Le, Sakr, Y., Vincent, Jl, Tomas, E., Bibonge, Ea, Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, A., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, Gv, Slavcovici, A., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, U., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Lee, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Nishida, O., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, Nn, Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Dsicu, Hamdy, An, Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, Om, Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J., Herridge, M., Fernandez-Medero, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Bauer, P., Wunderink, R., Jimenez, E., Ryan, A., Prince, D., Edington, J., Haren, F., Bersten, A., Hawkins, Dj, Kilminster, M., Sturgess, D., Ziegenfuss, M., O Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, Md, Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Melo, Lmc, Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, Vs, Filho, Rc, Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, Gc, Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, Lc, Duque, Gl, Diaz-Guio, D., Benitez, F., Urrego, Ag, Buitrago, R., Ortiz, G., Gaviria, Mv, Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, Mc, Carlos E. Orellana-Jimenez, Garrido, L., Diaz, O., Resiere, D., Osorio, C., La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, Rm, Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, Dr, Arrazola, F., Francisco, Lj, Liamendys-Silva, Sa, Hernandez, M., Cadena, Dr, Islas, Il, Zarzavilla, Cb, Matos, A., Oyanguren, I., Cerna, J., Sierra, Rq, Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, Sm, Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, D., Lahkar, B., Mandal, A., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Gurav, Kz, Patel, M., Bhaysar, A., Samaddar, D., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, U., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Gadisseux, P., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Waele, J., Rimachi, R., Gusu, D., Decker, K., Mandianga, K., Heytens, L., Spapen, H., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, Jy, Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Floccard, B., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, I., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, Mg, Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Penis, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Cate, Jt, Bormans, L., Husada, S., Buise, M., Hoven, B., Reidinga, A., Kuiper, M., Pickkers, P., Kluge, G., Den Boer, S., Kesecioglu, J., Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Oliveira, Av, Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, A., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, Mk, Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, Ap, Marina, L., Vidal-Cortes, P., Posada, I., Martin-Loeches, Ai, Guillen, Nm, Palomar, M., Sole-Violan, U., Torres, A., Gallego, Mg, Aguilar, G., Allue, Rm, Argueso, M., Parejo, M., Navarro, Mp, Jose, A., Nin, N., Lerma, Fa, Martinez, O., Lozano, Et, Lopez, Sa, Granda, Mp, Moreno, S., Llubia, C., Martos, Cd, Gonzalez-Arenas, P., Fernandez, Nl, Rueda, Bg, Pons, Ie, Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, Li, Quindos, B., Quintano, A., Tebar, M., Cardinal, I., Reyes, A., Rodriguez, A., Abella, A., Del Valle, Sg, Yus, S., Maseda, E., Berezo, U., Pedregosa, At, Laplaza, C., Ferrer, R., Rico-Feijoo, U., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Mathew, S., Downes, R., Groba, Cb, Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, U., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, U., Fletcher, N., Bray, B., Brealey, D., Intensive Care, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, UCL - (MGD) Services des soins intensifs, Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], and University of Wisconsin School of Medicine and Public Health
- Subjects
Adult ,Male ,medicine.medical_specialty ,Critical Illness ,Medizin ,Audit ,Critical Care and Intensive Care Medicine ,Sepsis ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,Epidemiology ,medicine ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,In patient ,Hospital Mortality ,Prospective Studies ,Mortality ,ComputingMilieux_MISCELLANEOUS ,Outcome ,Aged ,computer.programming_language ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,business.industry ,Critically ill ,ICU ,030208 emergency & critical care medicine ,Middle Aged ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Hospitalization ,Intensive Care Units ,Increased risk ,030228 respiratory system ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Female ,Observational study ,Icon ,business ,computer - Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world., Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure., Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying., Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved., C1 [Kotfis, Katarzyna] Pomeranian Med Univ, Dept Anaesthesiol Intens Therapy & Acute Intoxica, Szczecin, Poland., [Wittebole, Xavier] UCL, Clin Univ St Luc, Dept Crit Care, Brussels, Belgium., [Jaschinski, Ulrich] Klinikum Augsburg, Klin Anasthesiol & Operat Intens Med, Augsburg, Germany., [Sole-Violan, Jordi] Hosp Univ Gran Canaria Dr Negrin, Dept Intens Care, Las Palmas Gran Canaria, Spain., [Kashyap, Rahul] Mayo Clin, Dept Anesthesia Ei Perioperat Med, Rochester, MN USA., [Leone, Marc] Aix Marseille Univ, Hop Nord, AP HM, Serv Anesthesie & Reanimat, Marseille, France., [Nanchal, Rahul] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA., [Fontes, Luis E.] Hosp Alcides Carneiro, Petropolis Med Sch, Dept Intens Care & Evidence Based Med, Petropolis, Brazil., [Sakr, Yasser] Uniklinikum Jena, Dept Anesthesiol & Intens Care, Jena, Germany., [Vincent, Jean-Louis] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Route Lenn 808, B-1070 Brussels, Belgium., [Tomas, E.] Clin Sagrada Esperanca, Luanda, Angola., [Bibonge, E. Amisi] Clin Univ Kinshasa, Kinshasa, DEM REP CONGO., [Charra, B.] Chu Ibn Rochd Casablanca, Casablanca, Morocco., [Faroudy, M.] Ibn Sina Hosp, Rabat, Morocco., [Doedens, L.] Chris Hani Baragwanath Acad Hosp, Soweto, South Africa., [Farina, Z.] Grays Hosp, Pietermaritzburg, South Africa., [Adler, D.] Sandton Medi Clin, Sandton, South Africa., [Balkema, C.] Tygerberg Hosp, Cape Town, South Africa., [Kok, A.] Union Hosp Alberton, Alberton, South Africa., [Alaya, S.] Bizerte Hosp, Bizerte, Tunisia., [Gharsallah, H.] Mil Hosp Tunis, Tunis, Tunisia., [Muzha, D.] Natl Trauma Ctr & Mil Hosp, Tirana, Albania., [Temelkov, A.] Alexandrovska Univ Hosp, Sofia, Bulgaria., [Georgiev, G.] Emergency Univ Hosp Pirogov, Sofia, Bulgaria., [Simeonov, G.] Tokuda Hosp Sofia, Sofia, Bulgaria., [Tsaryanski, G.] Uh St Ekaterina Sofia, Sofia, Bulgaria., [Georgiev, S.] Univ Hosp Obstet & Gynaecol, Sofia, Bulgaria., [Seliman, A.] Univ Hosp Sveta Marina Varna, Varna, Bulgaria., [Vrankovic, S.] Gen Hosp Siben, Shibenik, Croatia., [Vucicevic, Z.] Univ Hosp Ctr Sestre Milosrdnice, Zagreb, Croatia., [Gornik, I] Univ Hosp Ctr Zagreb, Zagreb, Croatia., [Barsic, B.] Univ Hosp Infect Dis, Zagreb, Croatia., [Husedzinovic, I] Univ Hosp Dubrava, Zagreb, Croatia., [Pavlik, P.] Ctr Cardiovasc & Transplant Surg, Prague, Czech Republic., [Manak, J.] Charles Univ Hosp, Prague, Czech Republic., [Kieslichova, E.] IKEM, Prague, Czech Republic., [Turek, R.] KNTB Zlin AS, Prague, Czech Republic., [Fischer, M.] Krajska Nemocnice Liberec, Prague, Czech Republic., [Valkova, R.] Masarykova Nemocnice V Usti Labem, Labem, Czech Republic., [Dadak, L.] St Annes Univ Hosp Brno, Brno, Czech Republic., [Dostal, P.] Univ Hosp Haradec Kralove, Haradec Kralove, Czech Republic., [Malaska, J.] Univ Hosp Brno, Brno, Czech Republic., [Hajek, R.] Univ Hosp Olomouc, Olomouc, Czech Republic., [Zidkova, A.] Univ Hosp Plzen, Plzen, Czech Republic., [Lavicka, P.] Charles Univ Hosp Plzen, Plzen, Czech Republic., [Starkopf, J.] Tartu Univ Hosp, Tartu, Estonia., [Kheladze, Z.] Crit Care Med Inst, Gainesville, Georgia., [Chkhaidze, M.] Jo Ann Med Ctr, Tbilisi, Georgia., [Kaloiani, V] Kipshidze Cent Univ Hosp, Tbilisi, Georgia., [Medve, L.] Dr Kenessey Albert Hosp, Balassagyarmat, Hungary., [Sarkany, A.] Fejer Cty St George Teaching Hosp, Szekesfehervar, Hungary., [Kremer, I] Flor Ferenc Cty Hosp, Budapest, Hungary., [Marjanek, Z.] Javorszky Odon Hosp, Vac, Hungary., [Tamasi, P.] Peterfy Hosp Budapest, Budapest, Hungary., [Krupnova, I] Infectol Ctr Latvia, Riga, Latvia., [Vanags, I] Paul Stradins Clin Univ Hosp, Riga, Latvia., [Liguts, V] Riga East Clin Univ Hosp, Riga, Latvia., [Pilvinis, V] Hosp Lithuanian Univ Hlth Sci Kauno Klinikos, Kaunas, Lithuania., [Vosylius, S.] Vilnius Univ Hosp, Vilnius, Lithuania., [Kekstas, G.] HSICU, Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania., [Balciunas, M.] CICU, Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania., [Kolbusz, A.] Csk Mswia, Warsaw, Poland., [Kubler, A.] Med Univ, Wroclaw, Poland., [Mielczarek, B.] Med Univ Wroclaw, Wroclaw, Poland., [Mikaszewska-Sokolewicz, M.] Med Univ Warsaw, Warsaw, Poland., [Kotfis, K.] Pomeranian Med Univ, Szczecin, Poland., [Tamowicz, B.] Reg Hosp Poznan, Poznan, Poland., [Sulkowski, W.] Szpital Powiatowy W Ostrowi Mazowieckiej, Ostrow Mazowiecka, Poland., [Smuszkiewicz, P.] Univ Hosp, Poznan, Poland., [Pihowicz, A.] Wojewodzki Szpital Zakazny, Torun, Poland., [Trejnowska, E.] Wojewodzkie Ctr Med, Warsaw, Poland., [Hagau, N.] Emergency Cty Hosp Cluj, Cluj Napoca, Romania., [Filipescu, D.] Emergency Inst Cardiovasc Dis, Bucharest, Romania., [Droc, G.] Fundeni Clin Inst, Bucharest, Romania., [Lupu, M.] Galati Hosp, Bucharest, Romania., [Nica, A.] Lnbi Prof Dr Matei Bals, Bucharest, Romania., [Stoica, R.] Inst Pulmonol Marius Nasta, Bucharest, Romania., [Tomescu, D.] Inst Clin Fundeni, Bucharest, Romania., [Constantinescu, D.] Sfantul Pantelimon Hosp, Bucharest, Romania., [Zbaganu, G. Valcoreanu] Spitalul Cf 2 Bucuresti, Bucharest, Romania., [Slavcovici, A.] Iuliu Hatieganu Univ Med & Pharm, Teaching Hosp Infect Dis, Cluj Napoca, Romania., [Bagin, V] City Clin Hosp 40, St Petersburg, Russia., [Belsky, D.] City Hosp 40, St Petersburg, Russia., [Palyutin, S.] Clin Hosp NVNV Solovyev, Yaroslavl, Russia., [Shlyapnikov, S.] Emergency Res Inst NA Djanelidze, St Petersburg, Russia., [Bikkulova, D.] Fed Res Ctr Paediat Haematol Oncol & Immunol, Moscow, Russia., [Gritsan, A.] Krasnoyarsk State Med Univ, Krasnoyarsk Reg Hosp, Krasnoyarsk, Russia., [Natalia, G.] Med Assoc Novaya Bolnitsa, Ekaterinburg, Russia., [Makarenko, E.] Mil Med Acad, Ekaterinburg, Russia., [Kokhno, V] Novosibirsk Med Univ, Novosibirsk, Russia., [Tolkach, A.] Omsk Reg Clin Hosp, Omsk, Russia., [Kokarev, E.] Railway Hosp Khabarovsk, Khabarovsk, Russia., [Belotserkovskiy, B.] St Alexy Hosp, St Louis, France., [Zolotukhin, K.] State Dist Hosp, Moscow, Russia., [Kulabukhov, V] Vishnevsky Inst Surg, Moscow, Russia., [Soskic, L.] Clin Ctr Serbia, Clin Cardiac Surg, Belgrade, Serbia., [Palibrk, I] Clin Ctr Serbia, Clin Digest Surg, Belgrade, Serbia., [Jankovic, R.; Jovanovic, B.] Clin Ctr Nis, Clin Vasc Surg, Nish, Serbia., [Pandurovic, M.] Clin Ctr Serbia, Emergency Ctr, Belgrade, Serbia., [Bumbasirevic, V] Clin Ctr Belgrade, Emergency Ctr, Belgrade, Serbia., [Uljarevic, B.] Gen Univ Hosp, Belgrade, Serbia., [Surbatovic, M.] Mil Med Acad, Belgrade, Serbia., [Ladjevic, N.] Urol Hosp, Belgrade, Serbia., [Slobodianiuk, G.] Dist Hosp, Bratislava, Slovakia., [Sobona, V] Fac Hosp, Bratislava, Slovakia., [Cikova, A.] Univ Hosp Bratislava, Hosp Ruzinov ICU, Bratislava, Slovakia., [Gebhardtova, A.] Univ Hosp Ruzinov Bratislava, Bratislava, Slovakia., [Jun, C.] Qingdao Univ, Tertiary Hosp, Qingdao, Shandong, Peoples R China., [Yunbo, S.] Qingdao Univ, Affiliated Hosp, Med Coll, Qingdao, Shandong, Peoples R China., [Dong, U.] Beijing Canc Hosp, Beijing Inst Canc Res, Beijing, Peoples R China., [Feng, S.] Beijing Chaoyang Hosp, Beijing, Peoples R China., [Duan, M.] Beijing Friendship Hosp, Beijing, Peoples R China., [Xu, Y.] Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China., [Xue, X.] Beijing Univ Peoples Hosp, Beijing, Peoples R China., [Gao, T.] Beijing Luhe Hosp, Beijing, Peoples R China., [Xing, X.] Chinese Acad Med Sci, Canc Hosp, Beijing, Peoples R China., [Zhao, X.] China Acad Chinese Med Sci, Guang An Men Hosp, Beijing, Peoples R China., [Li, C.] Peoples Hosp, Chuxiong, Yunnan, Peoples R China., [Gengxihua, G.] Donge Cty Peoples Hosp Shandong Prov, Liaocheng, Shandong, Peoples R China., [Tan, H.] Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China., [Xu, J.] Fujian Prov Hosp, Fuzhou, Fujian, Peoples R China., [Jiang, L.] Capital Med Univ, Fuxing Hosp, Beijing, Peoples R China., [Tiehe, Q.] Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China., [Bingyu, Q.] Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China., [Shi, Q.] Xi An Jiao Tong Univ, Coll Med, Xian, Shaanxi, Peoples R China., [Lv, Z.] Kunming Third Peoples Hosp, Kunming, Yunnan, Peoples R China., [Zhang, L.] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China., [Jingtao, L.] 309th Hosp, Beijing, Peoples R China., [Zhen, Z.] China Med Univ, Hosp 1, Beijing, Peoples R China., [Wang, Z.] Peking Univ, Shougang Hosp, Beijing, Peoples R China., [Wang, T.] Peking Univ, Hosp 3, Beijing, Peoples R China., [Yuhong, L.] Pla Navy Gen Hosp, Beijing, Peoples R China., [Zhai, Q.] Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China., [Chen, Y.] Jiaotong Univ, Affiliated Med Sch, Ruijin Hosp, Shanghai, Peoples R China., [Wang, C.] Shandong Prov Hosp, Jinan, Shandong, Peoples R China., [Jiang, W.] Shanghai 10th Peoples Hosp, Shanghai, Peoples R China., [Ruilan, W.] Shanghai First Peoples Hosp, Shanghai, Peoples R China., [Chen, Y.; Xiaobo, H.] Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China., [Ge, H.] Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China., [Yan, T.] Affiliated Guiyang Med Coll, Guiyang, Guizhou, Peoples R China., [Yuhui, C.] Fudan Univ, Peoples Hosp Shanghai 5, Shanghai, Peoples R China., [Zhang, J.] Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China., [Jian-Hong, F.] Suzhou Univ, Affiliated Hosp 1, Suzhou, Peoples R China., [Zhu, H.] Xinjiang Med Univ, Affiliated Hosp 1, Urumqi, Peoples R China., [Huo, F.; Wang, Y.] Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China., [Li, C.] First Peoples Hosp Kunming, Kunming, Yunnan, Peoples R China., [Zhuang, M.] Gen Hosp Shenyang Mil Reg, Shenyang, Liaoning, Peoples R China., [Ma, Z.] Peoples Hosp Cangzhou, Cangzhou, Peoples R China., [Sun, J.] Jilin Univ, Hosp 2, Changchun, Jilin, Peoples R China., [Liuqingyue, L.] Second Peoples Hosp Liaocheng City Shandong Prov, Liaocheng, Shandong, Peoples R China., [Yang, M.] Third Xiangya Hosp, Changsha, Hunan, Peoples R China., [Meng, J.] Tongde Hosp Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China., [Ma, S.] Tongji Univ, Shanghai East Hosp, Shanghai, Peoples R China., [Kang, Y.] West China Hosp, Scu, Peoples R China., [Yu, L.] Wuhan Ctr Hosp, Wuhan, Hubei, Peoples R China., [Peng, Q.] Xiangya Hosp, Changsha, Hunan, Peoples R China., [Wei, Y.] Yantai Yuhuangding Hosp, Yantai, Peoples R China., [Zhang, W.] Yantaishan Hosp, Yantai, Shandong, Peoples R China., [Sun, R.] Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China., [Yeung, A.] Pamela Youde Nethersole Eastern Hosp, Hong Kong, Peoples R China., [Wan, W.] Princess Margaret Hosp, Hong Kong, Peoples R China., [Sin, K.] Queen Elizabeth Hosp, Hong Kong, Peoples R China., [Lee, K.] United Christian Hosp Hong Kong SAR, Hong Kong, Peoples R China., [Wijanti, M.] Anestesi, Yogyakarta, Indonesia., [Widodo, U.] Pku Muhammadiyah Bantu, Yogyakarta, Indonesia., [Samsirun, H.] Rd Mattaher Hosp Jambi, Jambi City, Indonesia., [Sugiman, T.] Rumah Sakit Pantai Lndah Kapuk, North Jakarta, Indonesia., [Wisudarti, C.] Sardjito Hosp, Yogyakarta, Indonesia., [Maskoen, T.] Sch Med Unpad, Hasan Sadikin Hosp, Bandung, Indonesia., [Hata, N.] Nippon Med Sch, Chiba Hokusoh Hosp, Inzai, Japan., [Kobe, Y.] Chiba Univ Hosp, Chiba, Japan., [Nishida, O.] Fujita Hlth Univ, Sch Med, Toyoake, Aichi, Japan., [Miyazaki, D.] Japanese Red Cross Maebashi Hosp, Maebashi, Gumma, Japan., [Nunomiya, S.] Jichi Med Univ Hosp, Shimotsuke, Japan., [Uchino, S.] Jikei Univ, Sch Med, Tokyo, Japan., [Kitamura, N.] Kimitsu Chuo Hosp, Kisarazu, Japan., [Yamashita, K.] Kochi Med Sch, Nankoku, Kochi, Japan., [Hashimoto, S.] Kyoto Prefectural Univ Med, Kyoto, Japan., [Fukushima, H.] Nara Med Univ Hosp, Kashihara, Nara, Japan., [Adib, N. Nik] Hosp Sultanah Nur Zahirah, Kuala Terengganu, Terengganu, Malaysia., [Tai, L.] Kuala Lumpur Hosp, Kuala Lumpur, Malaysia., [Tony, B.] Queen Elizabeth Hosp 2, Kota Kinabalu, Malaysia., [Bigornia, R.] Cebu Velez Gen Hosp, Cebu, Philippines., [Bigornia, R.] Perpetual Succour Hosp, Cebu, Philippines., [Palo, J.] Med City, Pasig, Philippines., [Chatterjee, S.] Alexandra Hosp, Singapore, Singapore., [Tan, B.] Natl Univ Hlth Syst, Singapore, Singapore., [Kong, A.] Singapore Gen Hosp, Singapore, Singapore., [Goh, S.] Tan Tock Seng Hosp, Singapore, Singapore., [Lee, C.] Natl Taiwan Univ Hosp, Taipei, Taiwan., [Pothirat, C.] Chiaingmai Univ, Maharaj Nakorn Chiangmai Hosp, Chiang Mai, Thailand., [Khwannimit, B.] Prince Songkla Univ, Hat Yai, Thailand., [Theerawit, P.] Ramathibodi Hosp, Bangkok, Thailand., [Pornsuriyasak, P.] Ramathibodi Hosp, Somdech Phra Debaratana Med Ctr, Bangkok, Thailand., [Piriyapatsom, A.] Mahidol Univ, Siriraj Hosp, Bangkok, Thailand., [Mukhtar, A.] Cairo Univ, Giza, Egypt., [Dsicu] Demerdash Surg Intens Care Unit, Cairo, Egypt., [Hamdy, A. Nabil] Ain Shams Fac Med, Cairo, Egypt., [Hosny, H.] Zaitoun Specialized Hosp, Cairo, Egypt., [Ashraf, A.] Gums, Tehran, Iran., [Mokhtari, M.] Sbums, Imam Hossein Hosp, Tehran, Iran., [Nowruzinia, S.] Imamreza Hosp, Mashhad, Razavi Khorasan, Iran., [Lotfi, A.] Laleh Hosp, Tehran, Iran., [Zand, F.] Shiraz Anesthesiol & Crit Care Res Ctr, Shiraz, Iran., [Nikandish, R.] Shiraz Univ Med Sci, Shiraz, Iran., [Moghaddam, O. Moradi] Tehran Med Sci Univ, Tehran, Iran., [Cohen, J.] Rabin Med Ctr, Petah Tiqwa, Israel., [Sold, O.] Sourasky Tel Aviv Med Ctr, Tel Aviv, Israel., [Sfeir, T.] Ctr Hosp Nord, Ettelbruck, Luxembourg., [Hasan, A.] Sohar Hosp, Sohar, Oman., [Abugaber, D.] Specialized Arab Hosp, Nablus, Palestine., [Ahmad, H.] Almana Gen Hosp, Khobar, Saudi Arabia., [Tantawy, T.] KFSHRC, Riyadh, Saudi Arabia., [Baharoom, S.] King Abdulaziz Med City Riyadh, Riyadh, Saudi Arabia., [Algethamy, H.] King Abdulaziz Univ, Jeddah, Saudi Arabia., [Amr, A.] King Saud Med City, Riyadh, Saudi Arabia., [Almekhlafi, G.] Riyadh Mil Hosp, Riyadh, Saudi Arabia., [Coskun, R.] Erciyes Univ, Med Fac, Kayseri, Turkey., [Sungur, M.] Erciyes Univ, Med Sch, Kayseri, Turkey., [Cosar, A.] Gulhane Mil Med Acad, Ankara, Turkey., [Gucyetmez, B.] Int Hosp, Istanbul, Turkey., [Demirkiran, O.] Istanbul Univ, Cerrahpasa Med Sch Hosp, Istanbul, Turkey., [Senturk, E.] Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey., [Ulusoy, H.] Karadeniz Tech Univ, Med Fac, Trabzon, Turkey., [Atalan, H.] Mem Atasehir Hosp, Istanbul, Turkey., [Serin, S.] Pamukkale Univ, Denizli, Turkey., [Kati, I] Yuzuncu Yil Univ, Med Fac, Van, Turkey., [Alnassrawi, Z.] Dubai Hosp, Dubai, U Arab Emirates., [Almemari, A.] Mafraq Hosp, Abu Dhabi, U Arab Emirates., [Krishnareddy, K.] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates., [Kashef, S.] Tawam Hosp, Al Ain, U Arab Emirates., [Alsabbah, A.] City Hosp, Dubai, U Arab Emirates., [Poirier, G.] Hop Charles Lemoyne, Longueuil, PQ, Canada., [Marshall, J.] St Michaels Hosp, Toronto, ON, Canada., [Herridge, M.] Toronto Gen Hosp, Toronto, ON, Canada., [Herridge, M.] Toronto Western Hosp, Toronto, ON, Canada., [Fernandez-Medero, R.] San Juan Hosp, San Juan, PR USA., [Fulda, G.] Christiana Care Hlth Syst, Newark, DE USA., [Banschbach, S.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA., [Quintero, J.] El Camino Hosp, Mountain View, CA USA., [Schroeder, E.] George Washington Hosp, Washington, DC USA., [Sicoutris, C.] Hosp Univ Penn, Philadelphia, PA 19104 USA., [Gueret, R.] John H Stroger Hosp Cook Cty, Chicago, IL USA., [Kashyap, R.] Mayo Clin, CCM, Rochester, MN USA., [Bauer, P.] Mayo Clin, PCC, Rochester, MN USA., [Nanchal, R.] Med Coll Wisconsin, Milwaukee, WI 53226 USA., [Wunderink, R.] Northwestern Mem Hosp, Chicago, IL 60611 USA., [Jimenez, E.] Orlando Reg Med Ctr Inc, Orlando, FL USA., [Ryan, A.] Washington Hosp Ctr, Washington, DC 20010 USA., [Ryan, A.] Washington Hosp Ctr, 2H, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 2G, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 3H, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 3G, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, 4H, Washington, DC USA., [Ryan, A.] Washington Hosp Ctr, CVRR, Washington, DC USA., [Prince, D.] Armadale Hlth Serv, Mount Nasura, WA, Australia., [Edington, J.] Bendigo Hosp, Bendigo, Vic, Australia., [Van Haren, F.] Canberra Hosp, Canberra, ACT, Australia., [Bersten, A.] Flinders Med Ctr, Bedford Pk, SA, Australia., [Hawkins, D. J.] Joondalup Hlth Campus, Joondalup, WA, Australia., [Kilminster, M.] Lismore Base Hosp, Lismore, NSW, Australia., [Sturgess, D.] Mater Adult Hosp, South Brisbane, Qld, Australia., [Ziegenfuss, M.] Prince Charles Hosp, Brisbane, Qld, Australia., [O'Connor, S.] Royal Adelaide Hosp, Adelaide, SA, Australia., [Lipman, J.] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia., [Campbell, L.] Royal Darwin Hosp, Tiwi, NT, Australia., [Mcallister, R.] Royal Hobart Hosp, Hobart, Tas, Australia., [Roberts, B.] Sir Charles Gairdner Hosp, Nedlands, WA, Australia., [Williams, P.] Queen Elizabeth Hosp, Woodville, SA, Australia., [Parke, R.] Auckland Dist Hlth Board, Auckland, New Zealand., [Seigne, P.] Christchurch Hosp, Christchurch, New Zealand., [Freebairn, R.] Hawkes Bay Hosp, Hastings, New Zealand., [Nistor, D.] Palmerston North Hosp, Midcent Hlth, Palmerston North, New Zealand., [Oxley, C.] Middlemore Hosp, Auckland, New Zealand., [Young, P.] Wellington Hosp, Wellington, New Zealand., [Valentini, R.] Cemic, Buenos Aires, DF, Argentina., [Wainsztein, N.] Fleni, Buenos Aires, DF, Argentina., [Comignani, P.] Hosp Aleman, Buenos Aires, DF, Argentina., [Casaretto, M.] Hosp Cent San Isidro, Buenos Aires, DF, Argentina., [Sutton, G.] Hosp Fernandez, Buenos Aires, DF, Argentina., [Villegas, P.] Hosp Francisco Lopez Lima Area Programa Gen Roca, Gen Roca, Argentina., [Galletti, C.] Sanatorio Allende, Cordoba, Argentina., [Neira, J.] Sanatorio Trinidad Palermo, Buenos Aires, DF, Argentina., [Rovira, D.] Sanatorio Julio Corzo Rosario, Rosario, Santa Fe, Argentina., [Hidalgo, J.] Karl Heusner Mem Hosp, Belize City, Belize., [Hidalgo, J.] Belize Healthcare Partner, Belize City, Belize., [Sandi, F.] Hosp Obrero 1, La Paz, Bolivia., [Caser, E.] Cias Unimed Vitoria, Vitoria, ES, Brazil., [Thompson, M.] Evangelical Hosp Cachoeiro De Itapemirim, Cachoeiro De Itapemirim, Brazil., [D'agostino Dias, M.] Hosp 9 Julho, Sao Paulo, Brazil., [Fontes, L.] Hosp Alcides Carneiro, Petropolis, Brazil., [Lunardi, M.] Hosp Clin Luzia De Pinho Melo, Mogi Das Cruzes, Brazil., [Youssef, N.] Hosp Nacoes Curitiba, Curitiba, Parana, Brazil., [Lobo, S.] Hosp Base Famerp, Sao Jose Do Rio Preto, Brazil., [Silva, R.] Hosp Clin Niteroi, Niteroi, RJ, Brazil., [Sales Jr, J.] Hosp Clin Padre Miguel, Rio De Janeiro, Brazil., [Madeira Campos Melo, L.] Hosp Terapia Intens, Sao Paulo, Brazil., [Oliveira, M.] Hosp Trabalhador, Curitiba, Parana, Brazil., [Fonte, M.] Hosp Esperanza, Olinda, PE, Brazil., [Grion, C.] Hosp Evangel Londrina, Londrina, Brazil., [Feijo, C.] Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil., [Rezende, V] Hosp Geral Roraima, Boa Vista, Brazil., [Assuncao, M.] Hosp Israelita Albert Einstein, Sao Paulo, Brazil., [Neves, A.] Hosp Mater Dei, Belo Horizonte, MG, Brazil., [Gusman, P.; Dalcomune, D.] Hosp Meridional, Cariacica, ES, Brazil., [Teixeira, C.] Hosp Moinhos Vento, Porto Alegre, RS, Brazil., [Kaefer, K.] Hosp Municipal Ruth Cardoso, Balneario, Brazil., [Maia, I] Hosp Nereu Ramos, Florianopolis, SC, Brazil., [Souza Dantas, V] Hosp Pasteur, Rio De Janeiro, Brazil., [Costa Filho, R.] Hosp Pro Cardiaco, Rio De Janeiro, Brazil., [Amorim, F.] Hosp Reg Samambaia, Brasilia, DF, Brazil., [Assef, M.] Hosp Reg Hans Dieter Schmidt, Joinville, Brazil., [Schiavetto, P.] Hosp Santa Casa Campo Mourao, Campo Mourao, PR, Brazil., [Houly, J.] Hosp Santa Paula, Sao Paulo, SP, Brazil., [Houly, J.] Hosp Santapaula, Sao Paulo, Brazil., [Bianchi, F.] Hosp Sao Jose Avai, Itaperuna, RJ, Brazil., [Dias, F.] Hosp Sao Lucas Pucrs, Porto Alegre, RS, Brazil., [Avila, C.] Hosp Sao Vicente Paula, Rio De Janeiro, RJ, Brazil., [Gomez, J.] Hosp Sao Vicente Paulo, Rio De Janeiro, Brazil., [Rego, L.] Hosp Saude Mulher, Belem, Para, Brazil., [Castro, P.] Hosp Tacchini, Bento Goncalves, RS, Brazil., [Passos, J.] Hosp Unimed Costa Do Sol Macae Rj, Macae, RJ, Brazil., [Mendes, C.] Hosp Univ Ufpb Joao Pessoa, Joao Pessoa, Paraiba, Brazil., [Grion, C.] Hosp Univ Londrina, Londrina, Brazil., [Colozza Mecatti, G.] Hosp Univ Sao Francisco, Braganca Paulista, SP, Brazil., [Ferrreira, M.] Santa Casa Caridade Diamantina, Diamantina, MG, Brazil., [Irineu, V] Santa Casa Misericordia Tatui, Tatui, Brazil., [Guerreiro, M.] Sao Francisco de Paula Hosp, Sao Francisco De Paula, RS, Brazil., [Ugarte, S.] Clin Indisa, Providencia, Chile., [Tomicic, V] Clin Las Lilas, Providencia, Chile., [Godoy, C.] Hosp Carlos Van Buren, Valparaiso, Chile., [Samaniego, W.] Hosp Trabajador Santiago, Santiago, Chile., [Escamilla, I] Hosp El Pino, San Bernardo, Chile., [Escamilla, I] Hosp Mutual De Seguridad, Santiago, Chile., [Castro Castro, L.] Ctr Med Imbanaco, Valle Del Cauca, Colombia., [Libreros Duque, G.] Clin Colombia Cali, Cali, Colombia., [Diaz-Guio, D.] Clin Del Cafe, Armenia, Colombia., [Benitez, F.] Clin La Estancia SA, Popayan, Colombia., [Guerra Urrego, A.] Clin Medellin, Medellin, Colombia., [Buitrago, R.] Fdn Clin Shaio, Bogota, Colombia., [Ortiz, G.] Hosp Santa Clara, Bogota, Colombia., [Villalba Gaviria, M.] Hosp Univ Fdn Santa Fe De Bogota, Bogota, Colombia., [Salas, D.] Calderon Guardia Hosp, San Jose, Costa Rica., [Ramirez-Arce, J.] Hosp Dr Rafael Angel Varlderon Guardia Ccss, San Jose, Costa Rica., [Salgado, E.] Clin La Merced, Quito, Ecuador., [Morocho, D.] Hosp Eugenio Espejo, Quito, Ecuador., [Vergara, J.] Hosp Luis Vernaza, Quito, Ecuador., [Chung Sang, M.] Shdug Sistema Hosp Docente De La Univ Guayaquil, Quito, Ecuador., [Orellana-Jimenez, C.] Gen Hosp, San Salvador, El Salvador., [Garrido, L.] Hosp Ctr Med, Guatemala City, Guatemala., [Diaz, O.] Inst Hondureno Seguro Social, La Ceiba, Honduras., [Resiere, D.] Ctr Hosp Univ Ft De France, Fort De France, Martinique, France., [Osorio, C.] Ctr Estatal Cuidados Crit, Salamanca, Mexico., [De La Vega, A.] Ctr Med Nacl 20 Noviembre Issste, Mexico City, DF, Mexico., [Carrillo, R.] Fdn Clin Med Sur, Mexico City, DF, Mexico., [Sanchez, V] Hosp San Jose TEC Monterrey, Monterrey, Mexico., [Villagomez, A.] Hosp 1 Octubre, Issste, Mexico., [Martinez Zubieta, R.] Hosp Espanol Mexico, Mexico City, DF, Mexico., [Sandia, M.] Hosp Gen Ajusco Medio, Mexico City, DF, Mexico., [Zalatiel, M.] Hosp Gen Guadalupe Victoria, Texcoco, Mexico., [Poblano, M.] Hosp Juarez Mexico, Mexico City, DF, Mexico., [Rodriguez Gonzalez, D.] Hosp Civil Guadalajara, Hspitaljuan I Menchaca, Guadalajara, Jalisco, Mexico., [Arrazola, F.; Juan Francisco, L.] Inst Mexicano Seguro Social, Mexico City, DF, Mexico., [Liamendys-Silva, S. A.] Inst Nacl Cancerol, Mexico City, DF, Mexico., [Hernandez, M.] ISSSTE Guerra Moya, Mexico City, DF, Mexico., [Hernandez, M.] Med Ctr ISSEMYM Toluca, Mexico City, DF, Mexico., [Rodriguez Cadena, D.] Mixta, Mexico City, DF, Mexico., [Lopez Islas, I.] Secretaria Salud Dist Fed, Mexico City, DF, Mexico., [Ballesteros Zarzavilla, C.] Hosp Santo Comas, Panama City, Panama., [Matos, A.] Social Secur Hosp, La Chorrera, Panama., [Oyanguren, I] Clin Anglo Amer, Lima, Peru., [Cerna, J.] Essalud, Lima, Peru., [Quispe Sierra, R.] Hosp Nacl Dos De Mayo, Lima, Peru., [Jimenez, R.] Hosp Rebagliati, Lince Dist, Peru., [Castillo, L.] Inst Nacl Enfermedades Neoplas, Surquillo, Peru., [Ocal, R.] Gulhane Med Fac, Istanbul, Turkey., [Sencan, A.] Izmir Ataturk Educ & Res Hosp, Izmir, Turkey., [Gianoni, S. Mareque] CAMS, Montevideo, Uruguay., [Deicas, A.] CASMU, Montevideo, Uruguay., [Hurtado, J.] Hosp Espanol Asse, Montevideo, Uruguay., [Burghi, G.] Hosp Maciel, Montevideo, Uruguay., [Martinelli, A.] Ctr Med Caracas, Caracas, Venezuela., [Von der Osten, I] Hosp Miguel Perez Carreno, Caracas, Venezuela., [Du Maine, C.] MSF Trauma Hosp Kunduz, Kunduz, Afghanistan., [Bhattacharyya, M.] Amri Hosp, Kolkata, India., [Bandyopadhyay, S.] Amri Hosp Salt Lake, Kolkata, W Bengal, India., [Yanamala, S.] Apollo Hosp, Hyderabad, India., [Gopal, P.] Apollo Hosp, Bangalore, Karnataka, India., [Sahu, S.] Apollo Hosp, Bhubaneswar, India., [Ibrahim, M.] Apollo Special Hosp, Chennai, Tamil Nadu, India., [Rathod, D.] Asian Heart Inst, Mumbai, Maharashtra, India., [Mukundan, N.] Baby Mem Hosp Ltd, Calicut, Kerala, India., [Dewan, A.] Batra Hosp & Mrc, New Delhi 110062, India., [Amin, P.] Bombay Hosp Inst Med Sci, Mumbai, Maharashtra, India., [Samavedam, S.] Care Hosp, Hyderabad, India., [Shah, B.] Cims Hosp, Ahmadabad, Gujarat, India., [Gurupal, D.] Columbiaasia Hosp, Mysore, Karnataka, India., [Lahkar, B.] Dispur Hosp, Gauhati, India., [Mandal, A.] Fortis Hosp, Bangalore, Karnataka, India., [Sircar, M.] Fortis Hosp, Noida, India., [Ghosh, S.] Fortis Escorts Hosp, Faridabad, India., [Balasubramani, V] Ganga Med Ctr & Hosp P Ltd, Coimbatore, Tamil Nadu, India., [Kapadia, F.] Hinduja Hosp, Mumbai, Maharashtra, India., [Vadi, S.] KDAH, Mumbai, Maharashtra, India., [Nair, K.] Kerala Inst Med Sci, RMCC, Thiruvananthapuram, Kerala, India., [Tripathy, S.] Kalinga Inst Med Sci, DTEM, Bhubaneswar, Odisha, India., [Nandakumar, S.] Kovai Med Ctr & Hosp, Coimbatore, Tamil Nadu, India., [Sharma, J.] Medanta Medic, Gurgaon, India., [Kar, A.] Med Superspecialty Hosp, Kolkata, W Bengal, India., [Jha, S.] Metro Heart Inst Multispecial, Faridabad, India., [Gurav, K. Zirpe] Ruby Hall Pune, Pune, Maharashtra, India., [Patel, M.] Saifee Hosp, Mumbai, Maharashtra, India., [Bhaysar, A.] Spandan Multispecial Hosp, Vadodara, India., [Samaddar, D.] Tata Main Hosp, Jamshedpur, Jharkhand, India., [Kulkarni, A.] Tata Mem Hosp, Mumbai, Maharashtra, India., [Hashmi, M.] Aga Khan Univ, Karachi, Pakistan., [Ali, W.] Hearts Int Hosp, Rawalpindi, Pakistan., [Nadeem, S.] Liaquat Natl Hosp, Karachi, Pakistan., [Indraratna, K.] Sri Jayewardenepura Gen Hosp, Sri Jayawardenepura Kott, Sri Lanka., [Margarit, A.] Hosp Nostra Senyora Meritxell, Les Escaldes, Andorra., [Urbanek, P.] Akh Wien, Vienna, Austria., [Schlieber, J.] Allgemeines & Orthopad Landeskrankenhaus Stolzalp, Stolzalpe, Austria., [Reisinger, J.] Barmherzige Schwestern Linz, Linz, Austria., [Auer, U.] Gen Hosp Braunau, Braunau, Austria., [Hartjes, A.] Krankenhaus D Barmherzigen Schwestern Ried II, Ried Im Innkreis, Austria., [Lerche, A.] Krankenhaus Floridsdorf, Vienna, Austria., [Janous, T.] LK Gmund Waidhofen Thaya Zwettl, Standort Zwettl, Austria., [Kink, E.] LKH Horgas Enzenbach, Gratwein, Austria., [Krahulec, W.] LKH West, Graz, Austria., [Smolle, K.] Univ Hosp, Graz, Austria., [Van der Schueren, M.] AZ Groeninge Kortrijk, Kortrijk, Belgium., [Thibo, P.] AZ Jan Palfijn Gent, Ghent, Belgium., [Vanhoof, M.] AZ Turnhout, Turnhout, Belgium., [Ahmet, I] Bracops Anderlecht, Anderlecht, Belgium., [Gadisseux, P.] Ctr Hosp Mouscron, Mouscron, Belgium., [Dufaye, P.] CH Peltzer La Tourelle, Verviers, Belgium., [Jacobs, O.] Chirec Edith Cavell, Auderghem, Belgium., [Fraipont, V] CHR Citadelle, Liege, Belgium., [Biston, P.] CHU Charleroi, Charleroi, Belgium., [Dive, A.] CHU Mt Godinne, Yvoir, Belgium., [Bouckaert, Y.] CHU Tivoli, La Louviere, Belgium., [Gilbert, E.] CHwapi, Tournai, Belgium., [Gressens, B.] Clin St Pierre Ottignies, Ottignies, Belgium., [Pinck, E.] Clin Maternite St Elisabeth, Namur, Belgium., [Collin, V] Clin Europe St Michel, Etterbeek, Belgium., [Vincent, J. L.] Erasme Univ Hosp, Anderlecht, Belgium., [De Waele, J.] Ghent Univ Hosp, Ghent, Belgium., [Rimachi, R.] Moliere Hosp, Forest, Belgium., [Gusu, D.] Notre Dame, Brussels, Belgium., [De Decker, K.] Onze Lieve Vrouw Hosp, Aalst, Belgium., [Mandianga, K.] Ixelles Hosp, Ixelles, Belgium., [Heytens, L.] Sint Augustinus, Antwerp, Belgium., [Wittebole, X.] St Luc Univ Hosp UCL, Brussels, Belgium., [Spapen, H.] UZ Brussel, Brussels, Belgium., [Olivier, V] Vivalia Site Libramt, Libramont, Belgium., [Vandenheede, W.] VZW Gezondheidszorg Oostkust Knokke Heist, Knokke Heist, Belgium., [Rogiers, P.] ZNA Middelheim, Antwerp, Belgium., [Kolodzeike, P.] Herning Hosp, Herning, Denmark., [Kruse, M.] Hjoerring Hosp, Hjorring, Denmark., [Andersen, T.] Vejle Hosp, Vejle, Denmark., [Harjola, V] Helsinki Univ Cent Hosp, Helsinki, Finland., [Saarinen, K.] Seinajoki Cent Hosp, Seinajoki, Finland., [Leone, M.] Aix Marseille Univ, Hop Nord, Marseille, France., [Durocher, A.] Calmette Hosp, Lille, France., [Moulront, S.] Ctr Hosp Dunkerque, Dunkerque, France., [Lepape, A.] Ctr Hosp Lyon Sud, Lyon, France., [Losser, M.] CHU Nancy Brabois, Nancy, France., [Cabaret, P.] CH St Philibert, GHICL, Lille, France., [Kalaitzis, E.] CHR Dax, Dax, France., [Zogheib, E.] CHU Amiens, Amiens, France., [Charve, P.] CHU Dijon, Dijon, France., [Francois, B.] CHU Dupuytren, Limoges, France., [Lefrant, J. Y.] CHU Nimes, Nimes, France., [Beilouny, B.] Ctr Hosp Troyes, Troyes, France., [Forceville, X.] Ctr Hosp Meaux, Grp Hosp Est Francilien, Meaux, France., [Misset, B.] Grp Hosp Paris St Joseph, Paris, France., [Jacobs, F.] Hop Antoine Beclere, Clamart, France., [Floccard, B.] Hop Edouard Herriot, Lyon, France., [Payen, D.] Hop Lariboisere, AP HP, Paris, France., [Wynckel, A.] Hop Maison Blanche, Reims, France., [Castelain, V] Hop Univ Strasbourg, Strasbourg, France., [Faure, A.] Hosp Civils Lyon, Lyon, France., [Lavagne, P.] CHU Grenoble, Grenoble, France., [Thierry, I] CHU Nantes, Nantes, France., [Moussa, M.] CHRU Lille, Reanimat Chirurg Cardiovasc, Lille, France., [Vieillard-Baron, A.] Univ Hosp Ambroise Pare, Boulogne, France., [Durand, M.] Univ Hosp Grenoble, La Tronche, France., [Gainnier, M.] Univ Hosp Marseille, Marseille, France., [Ichai, C.] Univ Nice, Nice, France., [Arens, S.] Alexianer Krefeld Gmbh, Krefeld, Germany., [Hoffmann, C.] Charite Hochschulmed Berlin, Berlin, Germany., [Kaffarnik, M.] Charite, Berlin, Germany., [Scharnofske, C.] Diakoniekrankenhaus Henriettenstiftung Gmbh, Hannover, Germany., [Voigt, I] Elisabeth Krankenhaus Essen, Essen, Germany., [Peckelsen, C.] Munich Municipal Hosp Grp, Harlaching Hosp, Munich, Germany., [Weber, M.] Helios St Johannes Klin, Duisburg, Germany., [Gille, J.] Hosp St Georg Leipzig, Leipzig, Germany., [Lange, A.] Klin Hennigsdorf Oberhavel Kliniken Gmbh, Hennigsdorf, Germany., [Schoser, G.] Klin Tettnang, Tettnang, Germany., [Sablotzki, A.] Klinikum St Georg Leipzig, Leipzig, Germany., [Jaschinski, U.; Bluethgen, A.] Klinikum Augsburg, Augsburg, Germany., [Vogel, F.] Klinikum Bremen Mitte, Bremen, Germany., [Tscheu, A.] Klinikum Bremen Ost, Bremen, Germany., [Fuchs, T.] Klinikum Heidenheim, Heidenheim, Germany., [Wattenberg, M.] Klinikum Links Weser Gmbh, Bremen, Germany., [Helmes, T.] Klinikum Luedenscheid, Luedenscheid, Germany., [Scieszka, S.] Krankenhaus Neuwerk, Monchengladbach, Germany., [Heintz, M.] Marienkrankenhaus Schwerte, Schwerte, Germany., [Sakka, S.] Med Ctr Cologne Merheim, Cologne, Germany., [Kohler, J.] Schwarzwald Baar Klinikum Villingen Schwenningen, Villingen Schwenningen, Germany., [Fiedler, F.] St Elisabeth Krankenhaus Koln Hohenlind, Cologne, Germany., [Danz, M.] St Martinus Hosp Olpe, Olpe, Germany., [Sakr, Y.] Uniklinikum Jena, Jena, Germany., [Riessen, R.] Univ Klinikum Tubingen, Tubingen, Germany., [Kerz, T.] Univ Med Mainz, Mainz, Germany., [Kersten, A.] Univ Hosp Aachen, CPACC, Aachen, Germany., [Tacke, F.] Univ Hosp Aachen, DMIII, Aachen, Germany., [Marx, G.] Univ Hosp Aachen, OIC, Aachen, Germany., [Volkert, T.] Univ Hosp Muenster, Munster, Germany., [Schmutz, A.] Univ Med Ctr Freiburg, Fr
- Published
- 2019
5. Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)
- Author
-
Vincent, J. -L., Lefrant, J. -Y., Kotfis, K., Nanchal, R., Martin-Loeches, I., Wittebole, X., Sakka, S. G., Pickkers, P., Moreno, R., Sakr, Y., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Židková, A., Lavicka, P., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Kolbusz, J., Kübler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Valcoreanu Zbaganu, G., Slavcovici, A., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Cohen, J., Sold, O., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Vincent, J. L., De Waele, J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J. Y., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Bernard, F., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, L., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Jaschinski, U., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Giannakou Peftoulidou, M., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Barry, J., O’Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Vintém De Oliveira, A., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nóbrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Kerin Povšic, M., Osojnik, I., Tomic, V., Sinkovic, A., González, J., Zavala, E., Pérez Valenzuela, J., Marina, L., Vidal-Cortés, P., Posada, P., Ignacio Martin-Loeches, A., Muñoz Guillén, N., Palomar, M., Sole-Violan, J., Torres, A., Gonzalez Gallego, M., Aguilar, G., Montoiro Allué, R., Argüeso, M., Parejo, M., Palomo Navarro, M., Jose, A., Nin, N., Alvarez Lerma, F., Martinez, O., Tenza Lozano, E., Arenal López, S., Perez Granda, M., Moreno, S., Llubia, C., De La Fuente Martos, C., Gonzalez-Arenas, P., Llamas Fernández, N., Gil Rueda, B., Estruch Pons, I., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Iglesias Fraile, L., Quindos, B., Quintano, A., Tebar, M., Cardinal, P., Reyes, A., Rodríguez, A., Abella, A., García Del Valle, S., Yus, S., Maseda, E., Berezo, J., Tejero Pedregosa, A., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodríguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Barrera Groba, C., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Delle Karth, G., Draxler, V., Filzwieser, G., Heindl, W., Kellner, G., Lenz, K., Rossmann, E., Wiedermann, C., Chochrad, D., Damas, P., Decruyenaere, J., Hoste, E., Devriendt, J., Espeel, B., Installe, E., Malbrain, M., Nollet, G., Preiser, J. C., Raemaekers, J., Roman, A., Simon, M., Spapen, H., Swinnen, W., Vallot, F., Chytra, I., Herold, I., Polak, F., Sterba, M., Bestle, M., Espersen, K., Guldager, H., Welling, K. -L., Nyman, D., Ruokonen, E., Annane, D., Catogni, P., Colas, G., Coulomb, F., Dorne, R., Garrouste, M., Isetta, C., Larché, J., LeGall, J. -R., Lessire, H., Malledant, Y., Mateu, P., Ossart, M., Schlossmacher, P., Timsit, J. -F., Winnock, S., Sollet, J. -P., Mallet, L., Maurer, P., Sab, J. M., Sollet, J. P., Aykut, G., Brunkhorst, F., Lauterbach, M., Ragaller, M., Gatz, R., Gerlach, H., Henzler, D., Hopf, H. -B., Hueneburg, H., Karzai, W., Keller, A., Bauer, T., Kuhlmann, U., Langgartner, J., Manhold, C., Reith, B., Schuerholz, T., Spies, C., Stögbauer, R., Unterburger, J., Clouva-Molyvdas, P. -M., Giokas, G., Ioannidou, E., Lahana, A., Liolios, A., Marathias, K., Tasiou, A., Tsangaris, H., Marsh, B., Power, M., Sprung, C., Biagioli, B., Bobbio Pallavicini, F., Pesenti, A., Della Corte, F., Donadio, P. P., Donati, A., Giorgio, T., Giudici, D., Greco, S., Guadagnucci, A., Lapichino, G., Livigni, S., Moise, G., Nardi, G., Panascia, E., Pizzamiglio, M., Ranieri, V. M., Rosi, R., Sicignano, A., Solca, M., Vignali, G., Volpe Rinonapoli, I., Barnas, M., De Bel, E. E., De Pont, A. -C., Groeneveld, J., Nijsten, M., Sie, L., Zandstra, D. F., Harboe, S., Lindén, S., Lovstad, R. Z., Moen, H., Smith-Erichsen, N., Piotrowski, A., Karpel, E., Pais-De-Lacerda, A., Paiva, J. A., Pimentel, A., Jovanovic, K., Malik, P., Lucka, K., Aldecoa Alvarez-Santullano, C., Artigas, A., Escorsell, A., Nicolas, J., Izura Cea, J. J., Montejo, J., Palencia, E., Santos, F., Sierra-Camerino, R., Sipmann, F., Brodersen, K., Haggqvist, J., Hermansson, D., Hjelmqvist, H., Loderer, G., Maggiorini, M., Andrews, P., Appadu, B., Bewley, J., Burchett, K., Chambers, P., Coakley, J., Doberenz, D., Eastwood, N., Fielden, J., Gedney, J., Gunning, K., Harling, D., Jankowski, S., Jayson, D., Kilner, A., Krishna-Kumar, V., Lei, K., Mackenzie, S., Macnaughton, P., McCulloch, C., Morgan, P., Rhodes, A., Roberts, C., Russell, M., Tupper-Carey, D., Wright, M., Twohey, L., Watts, J., Webster, R., Williams, D., on behalf of the ICON and SOAP investigators and SOAP investigators, Vincent, J.-L., Lefrant, J.-Y., Kotfis, K., Nanchal, R., Martin-Loeches, I., Wittebole, X., Sakka, S.G., Pickkers, P., Moreno, R., Sakr, Y., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Židková, A., Lavicka, P., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Kolbusz, J., Kübler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Valcoreanu Zbaganu, G., Slavcovici, A., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Cohen, J., Sold, O., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Vincent, J.L., De Waele, J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J.Y., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Bernard, F., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, L., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Jaschinski, U., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Giannakou Peftoulidou, M., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Barry, J., O’Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Vintém De Oliveira, A., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nóbrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Kerin Povšic, M., Osojnik, I., Tomic, V., Sinkovic, A., González, J., Zavala, E., Pérez Valenzuela, J., Marina, L., Vidal-Cortés, P., Posada, P., Ignacio Martin-Loeches, A., Muñoz Guillén, N., Palomar, M., Sole-Violan, J., Torres, A., Gonzalez Gallego, M., Aguilar, G., Montoiro Allué, R., Argüeso, M., Parejo, M., Palomo Navarro, M., Jose, A., Nin, N., Alvarez Lerma, F., Martinez, O., Tenza Lozano, E., Arenal López, S., Perez Granda, M., Moreno, S., Llubia, C., De La Fuente Martos, C., Gonzalez-Arenas, P., Llamas Fernández, N., Gil Rueda, B., Estruch Pons, I., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Iglesias Fraile, L., Quindos, B., Quintano, A., Tebar, M., Cardinal, P., Reyes, A., Rodríguez, A., Abella, A., García Del Valle, S., Yus, S., Maseda, E., Berezo, J., Tejero Pedregosa, A., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodríguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Barrera Groba, C., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Delle Karth, G., Draxler, V., Filzwieser, G., Heindl, W., Kellner, G., Lenz, K., Rossmann, E., Wiedermann, C., Chochrad, D., Damas, P., Decruyenaere, J., Hoste, E., Devriendt, J., Espeel, B., Installe, E., Malbrain, M., Nollet, G., Preiser, J.C., Raemaekers, J., Roman, A., Simon, M., Spapen, H., Swinnen, W., Vallot, F., Chytra, I., Herold, I., Polak, F., Sterba, M., Bestle, M., Espersen, K., Guldager, H., Welling, K.-L., Nyman, D., Ruokonen, E., Annane, D., Catogni, P., Colas, G., Coulomb, F., Dorne, R., Garrouste, M., Isetta, C., Larché, J., LeGall, J.-R., Lessire, H., Malledant, Y., Mateu, P., Ossart, M., Schlossmacher, P., Timsit, J.-F., Winnock, S., Sollet, J.-P., Mallet, L., Maurer, P., Sab, J.M., Sollet, J.P., Aykut, G., Brunkhorst, F., Lauterbach, M., Ragaller, M., Gatz, R., Gerlach, H., Henzler, D., Hopf, H.-B., Hueneburg, H., Karzai, W., Keller, A., Bauer, T., Kuhlmann, U., Langgartner, J., Manhold, C., Reith, B., Schuerholz, T., Spies, C., Stögbauer, R., Unterburger, J., Clouva-Molyvdas, P.-M., Giokas, G., Ioannidou, E., Lahana, A., Liolios, A., Marathias, K., Tasiou, A., Tsangaris, H., Marsh, B., Power, M., Sprung, C., Biagioli, B., Bobbio Pallavicini, F., Pesenti, A., Della Corte, F., Donadio, P.P., Donati, A., Giorgio, T., Giudici, D., Greco, S., Guadagnucci, A., Lapichino, G., Livigni, S., Moise, G., Nardi, G., Panascia, E., Pizzamiglio, M., Ranieri, V.M., Rosi, R., Sicignano, A., Solca, M., Vignali, G., Volpe Rinonapoli, I., Barnas, M., De Bel, E.E., De Pont, A.-C., Groeneveld, J., Nijsten, M., Sie, L., Zandstra, D.F., Harboe, S., Lindén, S., Lovstad, R.Z., Moen, H., Smith-Erichsen, N., Piotrowski, A., Karpel, E., Pais-De-Lacerda, A., Paiva, J.A., Pimentel, A., Jovanovic, K., Malik, P., Lucka, K., Aldecoa Alvarez-Santullano, C., Artigas, A., Escorsell, A., Nicolas, J., Izura Cea, J.J., Montejo, J., Palencia, E., Santos, F., Sierra-Camerino, R., Sipmann, F., Brodersen, K., Haggqvist, J., Hermansson, D., Hjelmqvist, H., Loderer, G., Maggiorini, M., Andrews, P., Appadu, B., Bewley, J., Burchett, K., Chambers, P., Coakley, J., Doberenz, D., Eastwood, N., Fielden, J., Gedney, J., Gunning, K., Harling, D., Jankowski, S., Jayson, D., Kilner, A., Krishna-Kumar, V., Lei, K., Mackenzie, S., Macnaughton, P., McCulloch, C., Morgan, P., Rhodes, A., Roberts, C., Russell, M., Tupper-Carey, D., Wright, M., Twohey, L., Watts, J., Webster, R., Williams, D., on behalf of the ICON and SOAP investigators and SOAP investigators, Université libre de Bruxelles (ULB), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), University of Wisconsin School of Medicine and Public Health, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Cliniques universitaires St Luc [Bruxelles], University Hospital of Cologne [Cologne], Radboud university [Nijmegen], Centro Hospitalar de Lisboa Central E.P.E, Intensive Care, Vincent, J, Lefrant, J, Kotfis, K, Nanchal, R, Martin-Loeches, I, Wittebole, X, Sakka, S, Pickkers, P, Moreno, R, Sakr, Y, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Cohen, J, Sold, O, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Giannakou Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, Vintem De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Kerin Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Perez Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Ignacio Martin-Loeches, A, Munoz Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Montoiro Allue, R, Argueso, M, Parejo, M, Palomo Navarro, M, Jose, A, Nin, N, Alvarez Lerma, F, Martinez, O, Tenza Lozano, E, Arenal Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, De La Fuente Martos, C, Gonzalez-Arenas, P, Llamas Fernandez, N, Gil Rueda, B, Estruch Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Iglesias Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Garcia Del Valle, S, Yus, S, Maseda, E, Berezo, J, Tejero Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Barrera Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Delle Karth, G, Draxler, V, Filzwieser, G, Heindl, W, Kellner, G, Lenz, K, Rossmann, E, Wiedermann, C, Chochrad, D, Damas, P, Decruyenaere, J, Hoste, E, Devriendt, J, Espeel, B, Installe, E, Malbrain, M, Nollet, G, Preiser, J, Raemaekers, J, Roman, A, Simon, M, Spapen, H, Swinnen, W, Vallot, F, Chytra, I, Herold, I, Polak, F, Sterba, M, Bestle, M, Espersen, K, Guldager, H, Welling, K, Nyman, D, Ruokonen, E, Annane, D, Catogni, P, Colas, G, Coulomb, F, Dorne, R, Garrouste, M, Isetta, C, Larche, J, Legall, J, Lessire, H, Malledant, Y, Mateu, P, Ossart, M, Schlossmacher, P, Timsit, J, Winnock, S, Sollet, J, Mallet, L, Maurer, P, Sab, J, Aykut, G, Brunkhorst, F, Lauterbach, M, Ragaller, M, Gatz, R, Gerlach, H, Henzler, D, Hopf, H, Hueneburg, H, Karzai, W, Keller, A, Bauer, T, Kuhlmann, U, Langgartner, J, Manhold, C, Reith, B, Schuerholz, T, Spies, C, Stogbauer, R, Unterburger, J, Clouva-Molyvdas, P, Giokas, G, Ioannidou, E, Lahana, A, Liolios, A, Marathias, K, Tasiou, A, Tsangaris, H, Marsh, B, Power, M, Sprung, C, Biagioli, B, Bobbio Pallavicini, F, Pesenti, A, Della Corte, F, Donadio, P, Donati, A, Giorgio, T, Giudici, D, Greco, S, Guadagnucci, A, Lapichino, G, Livigni, S, Moise, G, Nardi, G, Panascia, E, Pizzamiglio, M, Ranieri, V, Rosi, R, Sicignano, A, Solca, M, Vignali, G, Volpe Rinonapoli, I, Barnas, M, De Bel, E, De Pont, A, Groeneveld, J, Nijsten, M, Sie, L, Zandstra, D, Harboe, S, Linden, S, Lovstad, R, Moen, H, Smith-Erichsen, N, Piotrowski, A, Karpel, E, Pais-De-Lacerda, A, Paiva, J, Pimentel, A, Jovanovic, K, Malik, P, Lucka, K, Aldecoa Alvarez-Santullano, C, Artigas, A, Escorsell, A, Nicolas, J, Izura Cea, J, Montejo, J, Palencia, E, Santos, F, Sierra-Camerino, R, Sipmann, F, Brodersen, K, Haggqvist, J, Hermansson, D, Hjelmqvist, H, Loderer, G, Maggiorini, M, Andrews, P, Appadu, B, Bewley, J, Burchett, K, Chambers, P, Coakley, J, Doberenz, D, Eastwood, N, Fielden, J, Gedney, J, Gunning, K, Harling, D, Jankowski, S, Jayson, D, Kilner, A, Krishna-Kumar, V, Lei, K, Mackenzie, S, Macnaughton, P, Mcculloch, C, Morgan, P, Rhodes, A, Roberts, C, Russell, M, Tupper-Carey, D, Wright, M, Twohey, L, Watts, J, Webster, R, Williams, D, Supporting clinical sciences, Other departments, CHU Lille, Université de Lille, Unité de réanimation médicale [CHU de Carémeau, Nîmes], West Pomeranian University of Technology Szczecin, Universität Witten Herdecke, Radboud University [Nijmegen], Faculdade de Medicina de São José do Rio Preto [FAMERP], Jena University Hospital [Jena], Vincent, J. -L., Lefrant, J. -Y., Sakka, S. G., Zidkova, A., Kubler, A., O'Leary, R., Vintem De Oliveira, A., Nobrega, J., Kerin Povsic, M., Gonzalez, J., Perez Valenzuela, J., Vidal-Cortes, P., Munoz Guillen, N., Montoiro Allue, R., Argueso, M., Arenal Lopez, S., Llamas Fernandez, N., Rodriguez, A., Garcia Del Valle, S., Rodriguez, M., Preiser, J. C., Welling, K. -L., Larche, J., Legall, J. -R., Timsit, J. -F., Sollet, J. -P., Sab, J. M., Hopf, H. -B., Stogbauer, R., Clouva-Molyvdas, P. -M., Donadio, P. P., Ranieri, V. M., De Bel, E. E., De Pont, A. -C., Zandstra, D. F., Linden, S., Lovstad, R. Z., Paiva, J. A., Izura Cea, J. J., Mcculloch, C., Vincent J.-L., Lefrant J.-Y., Kotfis K., Nanchal R., Martin-Loeches I., Wittebole X., Sakka S.G., Pickkers P., Moreno R., Sakr Y., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Valcoreanu Zbaganu G., Slavcovici A., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Cohen J., Sold O., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Giannakou Peftoulidou M., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., Vintem De Oliveira A., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Kerin Povsic M., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Perez Valenzuela J., Marina L., Vidal-Cortes P., Posada P., Ignacio Martin-Loeches A., Munoz Guillen N., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M., Aguilar G., Montoiro Allue R., Argueso M., Parejo M., Palomo Navarro M., Jose A., Nin N., Alvarez Lerma F., Martinez O., Tenza Lozano E., Arenal Lopez S., Perez Granda M., Moreno S., Llubia C., De La Fuente Martos C., Gonzalez-Arenas P., Llamas Fernandez N., Gil Rueda B., Estruch Pons I., Cruza N., Maroto F., Estella A., Ferrer A., Iglesias Fraile L., Quindos B., Quintano A., Tebar M., Cardinal P., Reyes A., Rodriguez A., Abella A., Garcia Del Valle S., Yus S., Maseda E., Berezo J., Tejero Pedregosa A., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Barrera Groba C., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Delle Karth G., Draxler V., Filzwieser G., Heindl W., Kellner G., Lenz K., Rossmann E., Wiedermann C., Chochrad D., Damas P., Decruyenaere J., Hoste E., Devriendt J., Espeel B., Installe E., Malbrain M., Nollet G., Preiser J.C., Raemaekers J., Roman A., Simon M., Spapen H., Swinnen W., Vallot F., Chytra I., Herold I., Polak F., Sterba M., Bestle M., Espersen K., Guldager H., Welling K.-L., Nyman D., Ruokonen E., Annane D., Catogni P., Colas G., Coulomb F., Dorne R., Garrouste M., Isetta C., Larche J., LeGall J.-R., Lessire H., Malledant Y., Mateu P., Ossart M., Schlossmacher P., Timsit J.-F., Winnock S., Sollet J.-P., Mallet L., Maurer P., Sab J.M., Aykut G., Brunkhorst F., Lauterbach M., Ragaller M., Gatz R., Gerlach H., Henzler D., Hopf H.-B., Hueneburg H., Karzai W., Keller A., Bauer T., Kuhlmann U., Langgartner J., Manhold C., Reith B., Schuerholz T., Spies C., Stogbauer R., Unterburger J., Clouva-Molyvdas P.-M., Giokas G., Ioannidou E., Lahana A., Liolios A., Marathias K., Tasiou A., Tsangaris H., Marsh B., Power M., Sprung C., Biagioli B., Bobbio Pallavicini F., Pesenti A., Della Corte F., Donadio P.P., Donati A., Giorgio T., Giudici D., Greco S., Guadagnucci A., Lapichino G., Livigni S., Moise G., Nardi G., Panascia E., Pizzamiglio M., Ranieri V.M., Rosi R., Sicignano A., Solca M., Vignali G., Volpe Rinonapoli I., Barnas M., De Bel E.E., De Pont A.-C., Groeneveld J., Nijsten M., Sie L., Zandstra D.F., Harboe S., Linden S., Lovstad R.Z., Moen H., Smith-Erichsen N., Piotrowski A., Karpel E., Pais-De-Lacerda A., Paiva J.A., Pimentel A., Jovanovic K., Malik P., Lucka K., Aldecoa Alvarez-Santullano C., Artigas A., Escorsell A., Nicolas J., Izura Cea J.J., Montejo J., Palencia E., Santos F., Sierra-Camerino R., Sipmann F., Brodersen K., Haggqvist J., Hermansson D., Hjelmqvist H., Loderer G., Maggiorini M., Andrews P., Appadu B., Bewley J., Burchett K., Chambers P., Coakley J., Doberenz D., Eastwood N., Fielden J., Gedney J., Gunning K., Harling D., Jankowski S., Jayson D., Kilner A., Krishna-Kumar V., Lei K., Mackenzie S., Macnaughton P., McCulloch C., Morgan P., Rhodes A., Roberts C., Russell M., Tupper-Carey D., Wright M., Twohey L., Watts J., Webster R., and Williams D.
- Subjects
Male ,Original ,Epidemiology ,[SDV]Life Sciences [q-bio] ,HSJ UCI ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,MULTICENTER ,clinical outcome ,mortality rate ,Critical Care and Intensive Care Medicine ,intensive care unit ,law.invention ,0302 clinical medicine ,Severity of disease ,law ,middle aged ,Medicine and Health Sciences ,FAILURE ,030212 general & internal medicine ,Hospital Mortality ,intensive care units -- analysis -- epidemiology -- mortality ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,CODES ,comparative study ,intensive care ,Medicine(all) ,multilevel analysi ,Incidence ,adult ,Sciences bio-médicales et agricoles ,Intensive care unit ,3. Good health ,Europe ,sepsa ,Intensive Care Units ,female ,Cohort ,enote intenzivne terapije -- analiza -- epidemiologija -- umrljivost ,Human ,Adult ,medicine.medical_specialty ,severity of disease ,Critical Care ,Sepsi ,Intensive Care Unit ,UNITED-STATES ,610 Medicine & health ,INTENSIVE-CARE ,European ,Article ,Sepsis ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,length of stay ,male ,Humans ,Length of Stay ,Anesthesiology ,Intensive care ,SCORE ,medicine ,udc:614.2 ,human ,outcome assessment ,Septic shock ,business.industry ,SEPTIC SHOCK ,030208 emergency & critical care medicine ,medicine.disease ,TRENDS ,major clinical study ,SEVERE SEPSIS ,comorbidity assessment ,Emergency medicine ,Observational study ,CLAIMS ,business ,resnost bolezni - Abstract
Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 ± 17.0 vs. 60.6 ± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35–0.59), p < 0.001]. Conclusions: Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis., 0, info:eu-repo/semantics/published
- Published
- 2018
6. AB0 Incompatible Liver Transplantation for Fulminant Liver Failure- The Czech Experience.: Abstract# C1947
- Author
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Fronek, J., Janousek, L., Oliverius, M., Kucera, M., Kieslichova, E., Viklicky, O., and Trunecka, P.
- Published
- 2014
7. Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)
- Author
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Vincent, J, Lefrant, J, Kotfis, K, Nanchal, R, Martin-Loeches, I, Wittebole, X, Sakka, S, Pickkers, P, Moreno, R, Sakr, Y, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Cohen, J, Sold, O, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Giannakou Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, Vintem De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Kerin Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Perez Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Ignacio Martin-Loeches, A, Munoz Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Montoiro Allue, R, Argueso, M, Parejo, M, Palomo Navarro, M, Jose, A, Nin, N, Alvarez Lerma, F, Martinez, O, Tenza Lozano, E, Arenal Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, De La Fuente Martos, C, Gonzalez-Arenas, P, Llamas Fernandez, N, Gil Rueda, B, Estruch Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Iglesias Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Garcia Del Valle, S, Yus, S, Maseda, E, Berezo, J, Tejero Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Barrera Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Delle Karth, G, Draxler, V, Filzwieser, G, Heindl, W, Kellner, G, Lenz, K, Rossmann, E, Wiedermann, C, Chochrad, D, Damas, P, Decruyenaere, J, Hoste, E, Devriendt, J, Espeel, B, Installe, E, Malbrain, M, Nollet, G, Preiser, J, Raemaekers, J, Roman, A, Simon, M, Spapen, H, Swinnen, W, Vallot, F, Chytra, I, Herold, I, Polak, F, Sterba, M, Bestle, M, Espersen, K, Guldager, H, Welling, K, Nyman, D, Ruokonen, E, Annane, D, Catogni, P, Colas, G, Coulomb, F, Dorne, R, Garrouste, M, Isetta, C, Larche, J, Legall, J, Lessire, H, Malledant, Y, Mateu, P, Ossart, M, Schlossmacher, P, Timsit, J, Winnock, S, Sollet, J, Mallet, L, Maurer, P, Sab, J, Aykut, G, Brunkhorst, F, Lauterbach, M, Ragaller, M, Gatz, R, Gerlach, H, Henzler, D, Hopf, H, Hueneburg, H, Karzai, W, Keller, A, Bauer, T, Kuhlmann, U, Langgartner, J, Manhold, C, Reith, B, Schuerholz, T, Spies, C, Stogbauer, R, Unterburger, J, Clouva-Molyvdas, P, Giokas, G, Ioannidou, E, Lahana, A, Liolios, A, Marathias, K, Tasiou, A, Tsangaris, H, Marsh, B, Power, M, Sprung, C, Biagioli, B, Bobbio Pallavicini, F, Pesenti, A, Della Corte, F, Donadio, P, Donati, A, Giorgio, T, Giudici, D, Greco, S, Guadagnucci, A, Lapichino, G, Livigni, S, Moise, G, Nardi, G, Panascia, E, Pizzamiglio, M, Ranieri, V, Rosi, R, Sicignano, A, Solca, M, Vignali, G, Volpe Rinonapoli, I, Barnas, M, De Bel, E, De Pont, A, Groeneveld, J, Nijsten, M, Sie, L, Zandstra, D, Harboe, S, Linden, S, Lovstad, R, Moen, H, Smith-Erichsen, N, Piotrowski, A, Karpel, E, Pais-De-Lacerda, A, Paiva, J, Pimentel, A, Jovanovic, K, Malik, P, Lucka, K, Aldecoa Alvarez-Santullano, C, Artigas, A, Escorsell, A, Nicolas, J, Izura Cea, J, Montejo, J, Palencia, E, Santos, F, Sierra-Camerino, R, Sipmann, F, Brodersen, K, Haggqvist, J, Hermansson, D, Hjelmqvist, H, Loderer, G, Maggiorini, M, Andrews, P, Appadu, B, Bewley, J, Burchett, K, Chambers, P, Coakley, J, Doberenz, D, Eastwood, N, Fielden, J, Gedney, J, Gunning, K, Harling, D, Jankowski, S, Jayson, D, Kilner, A, Krishna-Kumar, V, Lei, K, Mackenzie, S, Macnaughton, P, Mcculloch, C, Morgan, P, Rhodes, A, Roberts, C, Russell, M, Tupper-Carey, D, Wright, M, Twohey, L, Watts, J, Webster, R, Williams, D, Vincent J. -L., Lefrant J. -Y., Kotfis K., Nanchal R., Martin-Loeches I., Wittebole X., Sakka S. G., Pickkers P., Moreno R., Sakr Y., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Valcoreanu Zbaganu G., Slavcovici A., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Cohen J., Sold O., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Giannakou Peftoulidou M., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., Vintem De Oliveira A., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Kerin Povsic M., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Perez Valenzuela J., Marina L., Vidal-Cortes P., Posada P., Ignacio Martin-Loeches A., Munoz Guillen N., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M., Aguilar G., Montoiro Allue R., Argueso M., Parejo M., Palomo Navarro M., Jose A., Nin N., Alvarez Lerma F., Martinez O., Tenza Lozano E., Arenal Lopez S., Perez Granda M., Moreno S., Llubia C., De La Fuente Martos C., Gonzalez-Arenas P., Llamas Fernandez N., Gil Rueda B., Estruch Pons I., Cruza N., Maroto F., Estella A., Ferrer A., Iglesias Fraile L., Quindos B., Quintano A., Tebar M., Cardinal P., Reyes A., Rodriguez A., Abella A., Garcia Del Valle S., Yus S., Maseda E., Berezo J., Tejero Pedregosa A., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Barrera Groba C., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Delle Karth G., Draxler V., Filzwieser G., Heindl W., Kellner G., Lenz K., Rossmann E., Wiedermann C., Chochrad D., Damas P., Decruyenaere J., Hoste E., Devriendt J., Espeel B., Installe E., Malbrain M., Nollet G., Preiser J. C., Raemaekers J., Roman A., Simon M., Spapen H., Swinnen W., Vallot F., Chytra I., Herold I., Polak F., Sterba M., Bestle M., Espersen K., Guldager H., Welling K. -L., Nyman D., Ruokonen E., Annane D., Catogni P., Colas G., Coulomb F., Dorne R., Garrouste M., Isetta C., Larche J., LeGall J. -R., Lessire H., Malledant Y., Mateu P., Ossart M., Schlossmacher P., Timsit J. -F., Winnock S., Sollet J. -P., Mallet L., Maurer P., Sab J. M., Aykut G., Brunkhorst F., Lauterbach M., Ragaller M., Gatz R., Gerlach H., Henzler D., Hopf H. -B., Hueneburg H., Karzai W., Keller A., Bauer T., Kuhlmann U., Langgartner J., Manhold C., Reith B., Schuerholz T., Spies C., Stogbauer R., Unterburger J., Clouva-Molyvdas P. -M., Giokas G., Ioannidou E., Lahana A., Liolios A., Marathias K., Tasiou A., Tsangaris H., Marsh B., Power M., Sprung C., Biagioli B., Bobbio Pallavicini F., Pesenti A., Della Corte F., Donadio P. P., Donati A., Giorgio T., Giudici D., Greco S., Guadagnucci A., Lapichino G., Livigni S., Moise G., Nardi G., Panascia E., Pizzamiglio M., Ranieri V. M., Rosi R., Sicignano A., Solca M., Vignali G., Volpe Rinonapoli I., Barnas M., De Bel E. E., De Pont A. -C., Groeneveld J., Nijsten M., Sie L., Zandstra D. F., Harboe S., Linden S., Lovstad R. Z., Moen H., Smith-Erichsen N., Piotrowski A., Karpel E., Pais-De-Lacerda A., Paiva J. A., Pimentel A., Jovanovic K., Malik P., Lucka K., Aldecoa Alvarez-Santullano C., Artigas A., Escorsell A., Nicolas J., Izura Cea J. J., Montejo J., Palencia E., Santos F., Sierra-Camerino R., Sipmann F., Brodersen K., Haggqvist J., Hermansson D., Hjelmqvist H., Loderer G., Maggiorini M., Andrews P., Appadu B., Bewley J., Burchett K., Chambers P., Coakley J., Doberenz D., Eastwood N., Fielden J., Gedney J., Gunning K., Harling D., Jankowski S., Jayson D., Kilner A., Krishna-Kumar V., Lei K., Mackenzie S., Macnaughton P., McCulloch C., Morgan P., Rhodes A., Roberts C., Russell M., Tupper-Carey D., Wright M., Twohey L., Watts J., Webster R., Williams D., Vincent, J, Lefrant, J, Kotfis, K, Nanchal, R, Martin-Loeches, I, Wittebole, X, Sakka, S, Pickkers, P, Moreno, R, Sakr, Y, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Cohen, J, Sold, O, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Giannakou Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, Vintem De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Kerin Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Perez Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Ignacio Martin-Loeches, A, Munoz Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Montoiro Allue, R, Argueso, M, Parejo, M, Palomo Navarro, M, Jose, A, Nin, N, Alvarez Lerma, F, Martinez, O, Tenza Lozano, E, Arenal Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, De La Fuente Martos, C, Gonzalez-Arenas, P, Llamas Fernandez, N, Gil Rueda, B, Estruch Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Iglesias Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Garcia Del Valle, S, Yus, S, Maseda, E, Berezo, J, Tejero Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Barrera Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Delle Karth, G, Draxler, V, Filzwieser, G, Heindl, W, Kellner, G, Lenz, K, Rossmann, E, Wiedermann, C, Chochrad, D, Damas, P, Decruyenaere, J, Hoste, E, Devriendt, J, Espeel, B, Installe, E, Malbrain, M, Nollet, G, Preiser, J, Raemaekers, J, Roman, A, Simon, M, Spapen, H, Swinnen, W, Vallot, F, Chytra, I, Herold, I, Polak, F, Sterba, M, Bestle, M, Espersen, K, Guldager, H, Welling, K, Nyman, D, Ruokonen, E, Annane, D, Catogni, P, Colas, G, Coulomb, F, Dorne, R, Garrouste, M, Isetta, C, Larche, J, Legall, J, Lessire, H, Malledant, Y, Mateu, P, Ossart, M, Schlossmacher, P, Timsit, J, Winnock, S, Sollet, J, Mallet, L, Maurer, P, Sab, J, Aykut, G, Brunkhorst, F, Lauterbach, M, Ragaller, M, Gatz, R, Gerlach, H, Henzler, D, Hopf, H, Hueneburg, H, Karzai, W, Keller, A, Bauer, T, Kuhlmann, U, Langgartner, J, Manhold, C, Reith, B, Schuerholz, T, Spies, C, Stogbauer, R, Unterburger, J, Clouva-Molyvdas, P, Giokas, G, Ioannidou, E, Lahana, A, Liolios, A, Marathias, K, Tasiou, A, Tsangaris, H, Marsh, B, Power, M, Sprung, C, Biagioli, B, Bobbio Pallavicini, F, Pesenti, A, Della Corte, F, Donadio, P, Donati, A, Giorgio, T, Giudici, D, Greco, S, Guadagnucci, A, Lapichino, G, Livigni, S, Moise, G, Nardi, G, Panascia, E, Pizzamiglio, M, Ranieri, V, Rosi, R, Sicignano, A, Solca, M, Vignali, G, Volpe Rinonapoli, I, Barnas, M, De Bel, E, De Pont, A, Groeneveld, J, Nijsten, M, Sie, L, Zandstra, D, Harboe, S, Linden, S, Lovstad, R, Moen, H, Smith-Erichsen, N, Piotrowski, A, Karpel, E, Pais-De-Lacerda, A, Paiva, J, Pimentel, A, Jovanovic, K, Malik, P, Lucka, K, Aldecoa Alvarez-Santullano, C, Artigas, A, Escorsell, A, Nicolas, J, Izura Cea, J, Montejo, J, Palencia, E, Santos, F, Sierra-Camerino, R, Sipmann, F, Brodersen, K, Haggqvist, J, Hermansson, D, Hjelmqvist, H, Loderer, G, Maggiorini, M, Andrews, P, Appadu, B, Bewley, J, Burchett, K, Chambers, P, Coakley, J, Doberenz, D, Eastwood, N, Fielden, J, Gedney, J, Gunning, K, Harling, D, Jankowski, S, Jayson, D, Kilner, A, Krishna-Kumar, V, Lei, K, Mackenzie, S, Macnaughton, P, Mcculloch, C, Morgan, P, Rhodes, A, Roberts, C, Russell, M, Tupper-Carey, D, Wright, M, Twohey, L, Watts, J, Webster, R, Williams, D, Vincent J. -L., Lefrant J. -Y., Kotfis K., Nanchal R., Martin-Loeches I., Wittebole X., Sakka S. G., Pickkers P., Moreno R., Sakr Y., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Valcoreanu Zbaganu G., Slavcovici A., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Cohen J., Sold O., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Giannakou Peftoulidou M., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., Vintem De Oliveira A., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Kerin Povsic M., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Perez Valenzuela J., Marina L., Vidal-Cortes P., Posada P., Ignacio Martin-Loeches A., Munoz Guillen N., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M., Aguilar G., Montoiro Allue R., Argueso M., Parejo M., Palomo Navarro M., Jose A., Nin N., Alvarez Lerma F., Martinez O., Tenza Lozano E., Arenal Lopez S., Perez Granda M., Moreno S., Llubia C., De La Fuente Martos C., Gonzalez-Arenas P., Llamas Fernandez N., Gil Rueda B., Estruch Pons I., Cruza N., Maroto F., Estella A., Ferrer A., Iglesias Fraile L., Quindos B., Quintano A., Tebar M., Cardinal P., Reyes A., Rodriguez A., Abella A., Garcia Del Valle S., Yus S., Maseda E., Berezo J., Tejero Pedregosa A., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Barrera Groba C., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Delle Karth G., Draxler V., Filzwieser G., Heindl W., Kellner G., Lenz K., Rossmann E., Wiedermann C., Chochrad D., Damas P., Decruyenaere J., Hoste E., Devriendt J., Espeel B., Installe E., Malbrain M., Nollet G., Preiser J. C., Raemaekers J., Roman A., Simon M., Spapen H., Swinnen W., Vallot F., Chytra I., Herold I., Polak F., Sterba M., Bestle M., Espersen K., Guldager H., Welling K. -L., Nyman D., Ruokonen E., Annane D., Catogni P., Colas G., Coulomb F., Dorne R., Garrouste M., Isetta C., Larche J., LeGall J. -R., Lessire H., Malledant Y., Mateu P., Ossart M., Schlossmacher P., Timsit J. -F., Winnock S., Sollet J. -P., Mallet L., Maurer P., Sab J. M., Aykut G., Brunkhorst F., Lauterbach M., Ragaller M., Gatz R., Gerlach H., Henzler D., Hopf H. -B., Hueneburg H., Karzai W., Keller A., Bauer T., Kuhlmann U., Langgartner J., Manhold C., Reith B., Schuerholz T., Spies C., Stogbauer R., Unterburger J., Clouva-Molyvdas P. -M., Giokas G., Ioannidou E., Lahana A., Liolios A., Marathias K., Tasiou A., Tsangaris H., Marsh B., Power M., Sprung C., Biagioli B., Bobbio Pallavicini F., Pesenti A., Della Corte F., Donadio P. P., Donati A., Giorgio T., Giudici D., Greco S., Guadagnucci A., Lapichino G., Livigni S., Moise G., Nardi G., Panascia E., Pizzamiglio M., Ranieri V. M., Rosi R., Sicignano A., Solca M., Vignali G., Volpe Rinonapoli I., Barnas M., De Bel E. E., De Pont A. -C., Groeneveld J., Nijsten M., Sie L., Zandstra D. F., Harboe S., Linden S., Lovstad R. Z., Moen H., Smith-Erichsen N., Piotrowski A., Karpel E., Pais-De-Lacerda A., Paiva J. A., Pimentel A., Jovanovic K., Malik P., Lucka K., Aldecoa Alvarez-Santullano C., Artigas A., Escorsell A., Nicolas J., Izura Cea J. J., Montejo J., Palencia E., Santos F., Sierra-Camerino R., Sipmann F., Brodersen K., Haggqvist J., Hermansson D., Hjelmqvist H., Loderer G., Maggiorini M., Andrews P., Appadu B., Bewley J., Burchett K., Chambers P., Coakley J., Doberenz D., Eastwood N., Fielden J., Gedney J., Gunning K., Harling D., Jankowski S., Jayson D., Kilner A., Krishna-Kumar V., Lei K., Mackenzie S., Macnaughton P., McCulloch C., Morgan P., Rhodes A., Roberts C., Russell M., Tupper-Carey D., Wright M., Twohey L., Watts J., Webster R., and Williams D.
- Abstract
Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 ± 17.0 vs. 60.6 ± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35–0.59), p < 0.001]. Conclusions: Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis.
- Published
- 2018
8. A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit
- Author
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Kotfis, Katarzyna Wittebole, Xavier Jaschinski, Ulrich and Sole-Violan, Jordi Kashyap, Rahul Leone, Marc Nanchal, Rahul and Fontes, Luis E. Sakr, Yasser Vincent, Jean-Louis Tomas, E. Bibonge, E. Amisi Charra, B. Faroudy, M. Doedens, L. and Farina, Z. Adler, D. Balkema, C. Kok, A. Alaya, S. and Gharsallah, H. Muzha, D. Temelkov, A. Georgiev, G. and Simeonov, G. Tsaryanski, G. Georgiev, S. Seliman, A. and Vrankovic, S. Vucicevic, Z. Gornik, I Barsic, B. and Husedzinovic, I Pavlik, P. Manak, J. Kieslichova, E. and Turek, R. Fischer, M. Valkova, R. Dadak, L. Dostal, P. and Malaska, J. Hajek, R. Zidkova, A. Lavicka, P. and Starkopf, J. Kheladze, Z. Chkhaidze, M. Kaloiani, V and Medve, L. Sarkany, A. Kremer, I Marjanek, Z. Tamasi, P. and Krupnova, I Vanags, I Liguts, V Pilvinis, V and Vosylius, S. Kekstas, G. Balciunas, M. Kolbusz, A. and Kubler, A. Mielczarek, B. Mikaszewska-Sokolewicz, M. Kotfis, K. Tamowicz, B. Sulkowski, W. Smuszkiewicz, P. Pihowicz, A. Trejnowska, E. Hagau, N. Filipescu, D. Droc, G. and Lupu, M. Nica, A. Stoica, R. Tomescu, D. Constantinescu, D. Zbaganu, G. Valcoreanu Slavcovici, A. Bagin, V and Belsky, D. Palyutin, S. Shlyapnikov, S. Bikkulova, D. and Gritsan, A. Natalia, G. Makarenko, E. Kokhno, V Tolkach, A. Kokarev, E. Belotserkovskiy, B. Zolotukhin, K. and Kulabukhov, V Soskic, L. Palibrk, I Jankovic, R. and Jovanovic, B. Pandurovic, M. Bumbasirevic, V Uljarevic, B. and Surbatovic, M. Ladjevic, N. Slobodianiuk, G. Sobona, V and Cikova, A. Gebhardtova, A. Jun, C. Yunbo, S. Dong, U. Feng, S. Duan, M. Xu, Y. Xue, X. Gao, T. and Xing, X. Zhao, X. Li, C. Gengxihua, G. Tan, H. Xu, J. Jiang, L. Tiehe, Q. Bingyu, Q. Shi, Q. Lv, Z. and Zhang, L. Jingtao, L. Zhen, Z. Wang, Z. Wang, T. and Yuhong, L. Zhai, Q. Chen, Y. Wang, C. Jiang, W. and Ruilan, W. Chen, Y. Xiaobo, H. Ge, H. Yan, T. Yuhui, C. Zhang, J. Jian-Hong, F. Zhu, H. Huo, F. Wang, Y. and Li, C. Zhuang, M. Ma, Z. Sun, J. Liuqingyue, L. and Yang, M. Meng, J. Ma, S. Kang, Y. Yu, L. Peng, Q. and Wei, Y. Zhang, W. Sun, R. Yeung, A. Wan, W. Sin, K. Lee, K. Wijanti, M. Widodo, U. Samsirun, H. and Sugiman, T. Wisudarti, C. Maskoen, T. Hata, N. Kobe, Y. and Nishida, O. Miyazaki, D. Nunomiya, S. Uchino, S. and Kitamura, N. Yamashita, K. Hashimoto, S. Fukushima, H. and Adib, N. Nik Tai, L. Tony, B. Bigornia, R. Palo, J. and Chatterjee, S. Tan, B. Kong, A. Goh, S. Lee, C. and Pothirat, C. Khwannimit, B. Theerawit, P. Pornsuriyasak, P. and Piriyapatsom, A. Mukhtar, A. Dsicu Hamdy, A. Nabil and Hosny, H. Ashraf, A. Mokhtari, M. Nowruzinia, S. Lotfi, A. Zand, F. Nikandish, R. Moghaddam, O. Moradi Cohen, J. and Sold, O. Sfeir, T. Hasan, A. Abugaber, D. Ahmad, H. and Tantawy, T. Baharoom, S. Algethamy, H. Amr, A. and Almekhlafi, G. Coskun, R. Sungur, M. Cosar, A. and Gucyetmez, B. Demirkiran, O. Senturk, E. Ulusoy, H. and Atalan, H. Serin, S. Kati, I Alnassrawi, Z. Almemari, A. and Krishnareddy, K. Kashef, S. Alsabbah, A. Poirier, G. and Marshall, J. Herridge, M. Herridge, M. Fernandez-Medero, R. and Fulda, G. Banschbach, S. Quintero, J. Schroeder, E. and Sicoutris, C. Gueret, R. Kashyap, R. Bauer, P. Nanchal, R. Wunderink, R. Jimenez, E. Ryan, A. Prince, D. and Edington, J. Van Haren, F. Bersten, A. Hawkins, D. J. and Kilminster, M. Sturgess, D. Ziegenfuss, M. O'Connor, S. and Lipman, J. Campbell, L. Mcallister, R. Roberts, B. and Williams, P. Parke, R. Seigne, P. Freebairn, R. Nistor, D. Oxley, C. Young, P. Valentini, R. Wainsztein, N. and Comignani, P. Casaretto, M. Sutton, G. Villegas, P. and Galletti, C. Neira, J. Rovira, D. Hidalgo, J. Sandi, F. and Caser, E. Thompson, M. D'agostino Dias, M. Fontes, L. and Lunardi, M. Youssef, N. Lobo, S. Silva, R. Sales Jr, J. Madeira Campos Melo, L. Oliveira, M. Fonte, M. Grion, C. Feijo, C. Rezende, V Assuncao, M. Neves, A. and Gusman, P. Dalcomune, D. Teixeira, C. Kaefer, K. Maia, I and Souza Dantas, V Costa Filho, R. Amorim, F. Assef, M. and Schiavetto, P. Houly, J. Bianchi, F. Dias, F. Avila, C. and Gomez, J. Rego, L. Castro, P. Passos, J. Mendes, C. and Grion, C. Colozza Mecatti, G. Ferrreira, M. Irineu, V and Guerreiro, M. Ugarte, S. Tomicic, V Godoy, C. and Samaniego, W. Escamilla, I Castro Castro, L. Libreros Duque, G. Diaz-Guio, D. Benitez, F. Guerra Urrego, A. Buitrago, R. Ortiz, G. Villalba Gaviria, M. Salas, D. and Ramirez-Arce, J. Salgado, E. Morocho, D. Vergara, J. and Chung Sang, M. Orellana-Jimenez, C. Garrido, L. Diaz, O. and Resiere, D. Osorio, C. De La Vega, A. Carrillo, R. and Sanchez, V Villagomez, A. Martinez Zubieta, R. Sandia, M. and Zalatiel, M. Poblano, M. Rodriguez Gonzalez, D. and Arrazola, F. Juan Francisco, L. Liamendys-Silva, S. A. and Hernandez, M. Rodriguez Cadena, D. Lopez Islas, I. and Ballesteros Zarzavilla, C. Matos, A. Oyanguren, I Cerna, J. and Quispe Sierra, R. Jimenez, R. Castillo, L. Ocal, R. and Sencan, A. Gianoni, S. Mareque Deicas, A. Hurtado, J. and Burghi, G. Martinelli, A. Von der Osten, I Du Maine, C. and Bhattacharyya, M. Bandyopadhyay, S. Yanamala, S. Gopal, P. and Sahu, S. Ibrahim, M. Rathod, D. Mukundan, N. Dewan, A. Amin, P. Samavedam, S. Shah, B. Gurupal, D. and Lahkar, B. Mandal, A. Sircar, M. Ghosh, S. and Balasubramani, V Kapadia, F. Vadi, S. Nair, K. Tripathy, S. Nandakumar, S. Sharma, J. Kar, A. Jha, S. Gurav, K. Zirpe Patel, M. Bhaysar, A. Samaddar, D. Kulkarni, A. and Hashmi, M. Ali, W. Nadeem, S. Indraratna, K. and Margarit, A. Urbanek, P. Schlieber, J. Reisinger, J. and Auer, U. Hartjes, A. Lerche, A. Janous, T. Kink, E. and Krahulec, W. Smolle, K. Van der Schueren, M. Thibo, P. and Vanhoof, M. Ahmet, I Gadisseux, P. Dufaye, P. Jacobs, O. and Fraipont, V Biston, P. Dive, A. Bouckaert, Y. and Gilbert, E. Gressens, B. Pinck, E. Collin, V Vincent, J. L. De Waele, J. Rimachi, R. Gusu, D. De Decker, K. and Mandianga, K. Heytens, L. Wittebole, X. Spapen, H. and Olivier, V Vandenheede, W. Rogiers, P. Kolodzeike, P. and Kruse, M. Andersen, T. Harjola, V Saarinen, K. Leone, M. and Durocher, A. Moulront, S. Lepape, A. Losser, M. and Cabaret, P. Kalaitzis, E. Zogheib, E. Charve, P. and Francois, B. Lefrant, J. Y. Beilouny, B. Forceville, X. and Misset, B. Jacobs, F. Floccard, B. Payen, D. Wynckel, A. and Castelain, V Faure, A. Lavagne, P. Thierry, I and Moussa, M. Vieillard-Baron, A. Durand, M. Gainnier, M. and Ichai, C. Arens, S. Hoffmann, C. Kaffarnik, M. and Scharnofske, C. Voigt, I Peckelsen, C. Weber, M. Gille, J. Lange, A. Schoser, G. Sablotzki, A. Jaschinski, U. and Bluethgen, A. Vogel, F. Tscheu, A. Fuchs, T. and Wattenberg, M. Helmes, T. Scieszka, S. Heintz, M. Sakka, S. Kohler, J. Fiedler, F. Danz, M. Sakr, Y. Riessen, R. Kerz, T. Kersten, A. Tacke, F. Marx, G. Volkert, T. Schmutz, A. Nierhaus, A. Kluge, S. Abel, P. and Janosi, R. Utzolino, S. Bracht, H. Toussaint, S. and Peftoulidou, M. Giannakou Myrianthefs, P. Armaganidis, A. and Routsi, C. Xini, A. Mouloudi, E. Kokoris, I and Kyriazopoulos, G. Vlachos, S. Lavrentieva, A. Partala, P. and Nakos, G. Moller, A. Stefansson, S. Barry, J. and O'Leary, R. Motherway, C. Faheem, M. Dunne, E. Donnelly, M. Konrad, T. Bonora, E. Achilli, C. Rossi, S. and Castiglione, G. Penis, A. Albanese, D. Stocchetti, N. and Citerio, G. Mozzoni, L. Sisillo, E. De Negri, P. and Savioli, M. Vecchiarelli, P. Puflea, F. Stankovic, V and Minoja, G. Montibeller, S. Calligaro, P. Sorrentino, R. and Feri, M. Zambon, M. Colombaroli, E. Giarratano, A. and Pellis, T. Capra, C. Antonelli, M. Gullo, A. Chelazzi, C. De Capraris, A. Patroniti, N. Girardis, M. Franchi, F. Berlot, G. Buttigieg, M. Ponssen, H. Cate, J. Ten and Bormans, L. Husada, S. Buise, M. Van Der Hoven, B. and Reidinga, A. Kuiper, M. Pickkers, P. Kluge, G. Den Boer, S. Kesecioglu, J. Van Leeuwen, H. Flaatten, H. Mo, S. and Branco, V Rua, F. Lafuente, E. Sousa, M. Catorze, N. and Barros, M. Pereira, L. De Oliveira, A. Vintern Gomes, J. and Gaspar, I Pereira, M. Cymbron, M. Dias, A. Almeida, E. Beirao, S. Serra, I Ribeiro, R. Povoa, P. Faria, F. Costa-E-Silva, Z. Nobrega, A. Fernandes, F. Gabriel, J. Voga, G. Rupnik, E. Kosec, L. Povsic, M. Kerin and Osojnik, I Tomic, V Sinkovic, A. Gonzalez, J. Zavala, E. and Perez Valenzuela, A. Marina, L. Vidal-Cortes, P. Posada, I Ignacio Martin-Loeches, A. Munoz Guillen, N. Palomar, M. and Sole-Violan, U. Torres, A. Gonzalez Gallego, M. Aguilar, G. Montoiro Allue, R. Argueso, M. Parejo, M. Palomo Navarro, M. Jose, A. Nin, N. Alvarez Lerma, F. Martinez, O. Tenza Lozano, E. Arenal Lopez, S. Perez Granda, M. and Moreno, S. Llubia, C. De la Fuente Martos, C. and Gonzalez-Arenas, P. Llamas Fernandez, N. Gil Rueda, B. and Estruch Pons, I Cruza, N. Maroto, F. Estella, A. Ferrer, A. Iglesias Fraile, L. Quindos, B. Quintano, A. Tebar, M. Cardinal, I Reyes, A. Rodriguez, A. Abella, A. and Garcia Del Valle, S. Yus, S. Maseda, E. Berezo, U. and Tejero Pedregosa, A. Laplaza, C. Ferrer, R. Rico-Feijoo, U. and Rodriguez, M. Monedero, P. Eriksson, K. Lind, D. and Chabanel, D. Zender, H. Heer, K. Frankenberger, B. and Jakob, S. Mathew, S. Downes, R. Groba, C. Barrera and Johnston, A. Meacher, R. Keays, R. Haji-Michael, P. and Tyler, C. Ferguson, A. Jones, S. Tyl, D. Ball, A. and Vogel, U. Booth, M. Downie, P. Watters, M. Brett, S. and Garfield, M. Everett, L. Heenen, S. Dhir, S. Beardow, Z. and Mostert, M. Brosnan, S. Pinto, N. Harris, S. and Summors, A. Andrew, N. Rose, A. Appelboam, R. Davies, O. and Vickers, E. Agarwal, B. Szakmany, T. Wimbush, S. and Welters, I Pearse, R. Hollands, R. Kirk-Bayley, U. and Fletcher, N. Bray, B. Brealey, D. ICON Investigators
- Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure. Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying. Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved.
- Published
- 2019
9. age: Observational data from the ICON audit
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Kotfis, K, Wittebole, X, Jaschinski, U, Sole-Violan, J, Kashyap, R, Leone, M, Nanchal, R, Fontes, LE, Sakr, Y, Vincent, JL, Tomas, E, Bibonge, EA, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, A, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Zbaganu, GV, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, U, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, NN, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Dsicu, Hamdy, AN, Hosny, H, Ashraf, A, Mokhtari, M, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, OM, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Almekhlafi, G, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Bauer, P, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, DJ, Kilminster, M, Sturgess, D, Ziegenfuss, M, O'Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, Dias, MD, Fontes, L, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, LMC, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, VS, Filho, RC, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Gomez, J, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, GC, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro, LC, Duque, GL, Diaz-Guio, D, Benitez, F, Urrego, AG, Buitrago, R, Ortiz, G, Gaviria, MV, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, MC, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, RM, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, DR, Arrazola, F, Francisco, LJ, Liamendys-Silva, SA, Hernandez, M, Cadena, DR, Islas, IL, Zarzavilla, CB, Matos, A, Oyanguren, I, Cerna, J, Sierra, RQ, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Gianoni, SM, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, D, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Gurav, KZ, Patel, M, Bhaysar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, U, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Spapen, H, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, JY, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, I, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, MG, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Penis, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Cate, JT, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Pickkers, P, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, AV, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, A, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, MK, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, AP, Marina, L, Vidal-Cortes, P, Posada, I, Martin-Loeches, AI, Guillen, NM, Palomar, M, Sole-Violan, U, Torres, A, Gallego, MG, Aguilar, G, Allue, RM, Argueso, M, Parejo, M, Navarro, MP, Jose, A, Nin, N, Lerma, FA, Martinez, O, Lozano, ET, Lopez, SA, Granda, MP, Moreno, S, Llubia, C, Martos, CD, Gonzalez-Arenas, P, Fernandez, NL, Rueda, BG, Pons, IE, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, LI, Quindos, B, Quintano, A, Tebar, M, Cardinal, I, Reyes, A, Rodriguez, A, Abella, A, Del Valle, SG, Yus, S, Maseda, E, Berezo, U, Pedregosa, AT, Laplaza, C, Ferrer, R, Rico-Feijoo, U, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Mathew, S, Downes, R, Groba, CB, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, U, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, U, Fletcher, N, Bray, B, and Brealey, D
- Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure. Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying. Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved. C1 [Kotfis, Katarzyna] Pomeranian Med Univ, Dept Anaesthesiol Intens Therapy & Acute Intoxica, Szczecin, Poland. [Wittebole, Xavier] UCL, Clin Univ St Luc, Dept Crit Care, Brussels, Belgium. [Jaschinski, Ulrich] Klinikum Augsburg, Klin Anasthesiol & Operat Intens Med, Augsburg, Germany. [Sole-Violan, Jordi] Hosp Univ Gran Canaria Dr Negrin, Dept Intens Care, Las Palmas Gran Canaria, Spain. [Kashyap, Rahul] Mayo Clin, Dept Anesthesia Ei Perioperat Med, Rochester, MN USA. [Leone, Marc] Aix Marseille Univ, Hop Nord, AP HM, Serv Anesthesie & Reanimat, Marseille, France. [Nanchal, Rahul] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA. [Fontes, Luis E.] Hosp Alcides Carneiro, Petropolis Med Sch, Dept Intens Care & Evidence Based Med, Petropolis, Brazil. [Sakr, Yasser] Uniklinikum Jena, Dept Anesthesiol & Intens Care, Jena, Germany. [Vincent, Jean-Louis] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Route Lenn 808, B-1070 Brussels, Belgium. [Tomas, E.] Clin Sagrada Esperanca, Luanda, Angola. [Bibonge, E. Amisi] Clin Univ Kinshasa, Kinshasa, DEM REP CONGO. [Charra, B.] Chu Ibn Rochd Casablanca, Casablanca, Morocco. [Faroudy, M.] Ibn Sina Hosp, Rabat, Morocco. [Doedens, L.] Chris Hani Baragwanath Acad Hosp, Soweto, South Africa. [Farina, Z.] Grays Hosp, Pietermaritzburg, South Africa. [Adler, D.] Sandton Medi Clin, Sandton, South Africa. [Balkema, C.] Tygerberg Hosp, Cape Town, South Africa. [Kok, A.] Union Hosp Alberton, Alberton, South Africa. [Alaya, S.] Bizerte Hosp, Bizerte, Tunisia. [Gharsallah, H.] Mil Hosp Tunis, Tunis, Tunisia. [Muzha, D.] Natl Trauma Ctr & Mil Hosp, Tirana, Albania. [Temelkov, A.] Alexandrovska Univ Hosp, Sofia, Bulgaria. [Georgiev, G.] Emergency Univ Hosp Pirogov, Sofia, Bulgaria. [Simeonov, G.] Tokuda Hosp Sofia, Sofia, Bulgaria. [Tsaryanski, G.] Uh St Ekaterina Sofia, Sofia, Bulgaria. [Georgiev, S.] Univ Hosp Obstet & Gynaecol, Sofia, Bulgaria. [Seliman, A.] Univ Hosp Sveta Marina Varna, Varna, Bulgaria. [Vrankovic, S.] Gen Hosp Siben, Shibenik, Croatia. [Vucicevic, Z.] Univ Hosp Ctr Sestre Milosrdnice, Zagreb, Croatia. [Gornik, I] Univ Hosp Ctr Zagreb, Zagreb, Croatia. [Barsic, B.] Univ Hosp Infect Dis, Zagreb, Croatia. [Husedzinovic, I] Univ Hosp Dubrava, Zagreb, Croatia. [Pavlik, P.] Ctr Cardiovasc & Transplant Surg, Prague, Czech Republic. [Manak, J.] Charles Univ Hosp, Prague, Czech Republic. [Kieslichova, E.] IKEM, Prague, Czech Republic. [Turek, R.] KNTB Zlin AS, Prague, Czech Republic. [Fischer, M.] Krajska Nemocnice Liberec, Prague, Czech Republic. [Valkova, R.] Masarykova Nemocnice V Usti Labem, Labem, Czech Republic. [Dadak, L.] St Annes Univ Hosp Brno, Brno, Czech Republic. [Dostal, P.] Univ Hosp Haradec Kralove, Haradec Kralove, Czech Republic. [Malaska, J.] Univ Hosp Brno, Brno, Czech Republic. [Hajek, R.] Univ Hosp Olomouc, Olomouc, Czech Republic. [Zidkova, A.] Univ Hosp Plzen, Plzen, Czech Republic. [Lavicka, P.] Charles Univ Hosp Plzen, Plzen, Czech Republic. [Starkopf, J.] Tartu Univ Hosp, Tartu, Estonia. [Kheladze, Z.] Crit Care Med Inst, Gainesville, Georgia. [Chkhaidze, M.] Jo Ann Med Ctr, Tbilisi, Georgia. [Kaloiani, V] Kipshidze Cent Univ Hosp, Tbilisi, Georgia. [Medve, L.] Dr Kenessey Albert Hosp, Balassagyarmat, Hungary. [Sarkany, A.] Fejer Cty St George Teaching Hosp, Szekesfehervar, Hungary. [Kremer, I] Flor Ferenc Cty Hosp, Budapest, Hungary. [Marjanek, Z.] Javorszky Odon Hosp, Vac, Hungary. [Tamasi, P.] Peterfy Hosp Budapest, Budapest, Hungary. [Krupnova, I] Infectol Ctr Latvia, Riga, Latvia. [Vanags, I] Paul Stradins Clin Univ Hosp, Riga, Latvia. [Liguts, V] Riga East Clin Univ Hosp, Riga, Latvia. [Pilvinis, V] Hosp Lithuanian Univ Hlth Sci Kauno Klinikos, Kaunas, Lithuania. [Vosylius, S.] Vilnius Univ Hosp, Vilnius, Lithuania. [Kekstas, G.] HSICU, Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania. [Balciunas, M.] CICU, Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania. [Kolbusz, A.] Csk Mswia, Warsaw, Poland. [Kubler, A.] Med Univ, Wroclaw, Poland. [Mielczarek, B.] Med Univ Wroclaw, Wroclaw, Poland. [Mikaszewska-Sokolewicz, M.] Med Univ Warsaw, Warsaw, Poland. [Kotfis, K.] Pomeranian Med Univ, Szczecin, Poland. [Tamowicz, B.] Reg Hosp Poznan, Poznan, Poland. [Sulkowski, W.] Szpital Powiatowy W Ostrowi Mazowieckiej, Ostrow Mazowiecka, Poland. [Smuszkiewicz, P.] Univ Hosp, Poznan, Poland. [Pihowicz, A.] Wojewodzki Szpital Zakazny, Torun, Poland. [Trejnowska, E.] Wojewodzkie Ctr Med, Warsaw, Poland. [Hagau, N.] Emergency Cty Hosp Cluj, Cluj Napoca, Romania. [Filipescu, D.] Emergency Inst Cardiovasc Dis, Bucharest, Romania. [Droc, G.] Fundeni Clin Inst, Bucharest, Romania. [Lupu, M.] Galati Hosp, Bucharest, Romania. [Nica, A.] Lnbi Prof Dr Matei Bals, Bucharest, Romania. [Stoica, R.] Inst Pulmonol Marius Nasta, Bucharest, Romania. [Tomescu, D.] Inst Clin Fundeni, Bucharest, Romania. [Constantinescu, D.] Sfantul Pantelimon Hosp, Bucharest, Romania. [Zbaganu, G. Valcoreanu] Spitalul Cf 2 Bucuresti, Bucharest, Romania. [Slavcovici, A.] Iuliu Hatieganu Univ Med & Pharm, Teaching Hosp Infect Dis, Cluj Napoca, Romania. [Bagin, V] City Clin Hosp 40, St Petersburg, Russia. [Belsky, D.] City Hosp 40, St Petersburg, Russia. [Palyutin, S.] Clin Hosp NVNV Solovyev, Yaroslavl, Russia. [Shlyapnikov, S.] Emergency Res Inst NA Djanelidze, St Petersburg, Russia. [Bikkulova, D.] Fed Res Ctr Paediat Haematol Oncol & Immunol, Moscow, Russia. [Gritsan, A.] Krasnoyarsk State Med Univ, Krasnoyarsk Reg Hosp, Krasnoyarsk, Russia. [Natalia, G.] Med Assoc Novaya Bolnitsa, Ekaterinburg, Russia. [Makarenko, E.] Mil Med Acad, Ekaterinburg, Russia. [Kokhno, V] Novosibirsk Med Univ, Novosibirsk, Russia. [Tolkach, A.] Omsk Reg Clin Hosp, Omsk, Russia. [Kokarev, E.] Railway Hosp Khabarovsk, Khabarovsk, Russia. [Belotserkovskiy, B.] St Alexy Hosp, St Louis, France. [Zolotukhin, K.] State Dist Hosp, Moscow, Russia. [Kulabukhov, V] Vishnevsky Inst Surg, Moscow, Russia. [Soskic, L.] Clin Ctr Serbia, Clin Cardiac Surg, Belgrade, Serbia. [Palibrk, I] Clin Ctr Serbia, Clin Digest Surg, Belgrade, Serbia. [Jankovic, R.; Jovanovic, B.] Clin Ctr Nis, Clin Vasc Surg, Nish, Serbia. [Pandurovic, M.] Clin Ctr Serbia, Emergency Ctr, Belgrade, Serbia. [Bumbasirevic, V] Clin Ctr Belgrade, Emergency Ctr, Belgrade, Serbia. [Uljarevic, B.] Gen Univ Hosp, Belgrade, Serbia. [Surbatovic, M.] Mil Med Acad, Belgrade, Serbia. [Ladjevic, N.] Urol Hosp, Belgrade, Serbia. [Slobodianiuk, G.] Dist Hosp, Bratislava, Slovakia. [Sobona, V] Fac Hosp, Bratislava, Slovakia. [Cikova, A.] Univ Hosp Bratislava, Hosp Ruzinov ICU, Bratislava, Slovakia. [Gebhardtova, A.] Univ Hosp Ruzinov Bratislava, Bratislava, Slovakia. [Jun, C.] Qingdao Univ, Tertiary Hosp, Qingdao, Shandong, Peoples R China. [Yunbo, S.] Qingdao Univ, Affiliated Hosp, Med Coll, Qingdao, Shandong, Peoples R China. [Dong, U.] Beijing Canc Hosp, Beijing Inst Canc Res, Beijing, Peoples R China. [Feng, S.] Beijing Chaoyang Hosp, Beijing, Peoples R China. [Duan, M.] Beijing Friendship Hosp, Beijing, Peoples R China. [Xu, Y.] Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China. [Xue, X.] Beijing Univ Peoples Hosp, Beijing, Peoples R China. [Gao, T.] Beijing Luhe Hosp, Beijing, Peoples R China. [Xing, X.] Chinese Acad Med Sci, Canc Hosp, Beijing, Peoples R China. [Zhao, X.] China Acad Chinese Med Sci, Guang An Men Hosp, Beijing, Peoples R China. [Li, C.] Peoples Hosp, Chuxiong, Yunnan, Peoples R China. [Gengxihua, G.] Donge Cty Peoples Hosp Shandong Prov, Liaocheng, Shandong, Peoples R China. [Tan, H.] Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China. [Xu, J.] Fujian Prov Hosp, Fuzhou, Fujian, Peoples R China. [Jiang, L.] Capital Med Univ, Fuxing Hosp, Beijing, Peoples R China. [Tiehe, Q.] Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China. [Bingyu, Q.] Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China. [Shi, Q.] Xi An Jiao Tong Univ, Coll Med, Xian, Shaanxi, Peoples R China. [Lv, Z.] Kunming Third Peoples Hosp, Kunming, Yunnan, Peoples R China. [Zhang, L.] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China. [Jingtao, L.] 309th Hosp, Beijing, Peoples R China. [Zhen, Z.] China Med Univ, Hosp 1, Beijing, Peoples R China. [Wang, Z.] Peking Univ, Shougang Hosp, Beijing, Peoples R China. [Wang, T.] Peking Univ, Hosp 3, Beijing, Peoples R China. [Yuhong, L.] Pla Navy Gen Hosp, Beijing, Peoples R China. [Zhai, Q.] Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China. [Chen, Y.] Jiaotong Univ, Affiliated Med Sch, Ruijin Hosp, Shanghai, Peoples R China. [Wang, C.] Shandong Prov Hosp, Jinan, Shandong, Peoples R China. [Jiang, W.] Shanghai 10th Peoples Hosp, Shanghai, Peoples R China. [Ruilan, W.] Shanghai First Peoples Hosp, Shanghai, Peoples R China. [Chen, Y.; Xiaobo, H.] Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China. [Ge, H.] Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China. [Yan, T.] Affiliated Guiyang Med Coll, Guiyang, Guizhou, Peoples R China. [Yuhui, C.] Fudan Univ, Peoples Hosp Shanghai 5, Shanghai, Peoples R China. [Zhang, J.] Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China. [Jian-Hong, F.] Suzhou Univ, Affiliated Hosp 1, Suzhou, Peoples R China. [Zhu, H.] Xinjiang Med Univ, Affiliated Hosp 1, Urumqi, Peoples R China. [Huo, F.; Wang, Y.] Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China. [Li, C.] First Peoples Hosp Kunming, Kunming, Yunnan, Peoples R China. [Zhuang, M.] Gen Hosp Shenyang Mil Reg, Shenyang, Liaoning, Peoples R China. [Ma, Z.] Peoples Hosp Cangzhou, Cangzhou, Peoples R China. [Sun, J.] Jilin Univ, Hosp 2, Changchun, Jilin, Peoples R China. [Liuqingyue, L.] Second Peoples Hosp Liaocheng City Shandong Prov, Liaocheng, Shandong, Peoples R China. [Yang, M.] Third Xiangya Hosp, Changsha, Hunan, Peoples R China. [Meng, J.] Tongde Hosp Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China. [Ma, S.] Tongji Univ, Shanghai East Hosp, Shanghai, Peoples R China. [Kang, Y.] West China Hosp, Scu, Peoples R China. [Yu, L.] Wuhan Ctr Hosp, Wuhan, Hubei, Peoples R China. [Peng, Q.] Xiangya Hosp, Changsha, Hunan, Peoples R China. [Wei, Y.] Yantai Yuhuangding Hosp, Yantai, Peoples R China. [Zhang, W.] Yantaishan Hosp, Yantai, Shandong, Peoples R China. [Sun, R.] Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China. [Yeung, A.] Pamela Youde Nethersole Eastern Hosp, Hong Kong, Peoples R China. [Wan, W.] Princess Margaret Hosp, Hong Kong, Peoples R China. [Sin, K.] Queen Elizabeth Hosp, Hong Kong, Peoples R China. [Lee, K.] United Christian Hosp Hong Kong SAR, Hong Kong, Peoples R China. [Wijanti, M.] Anestesi, Yogyakarta, Indonesia. [Widodo, U.] Pku Muhammadiyah Bantu, Yogyakarta, Indonesia. [Samsirun, H.] Rd Mattaher Hosp Jambi, Jambi City, Indonesia. [Sugiman, T.] Rumah Sakit Pantai Lndah Kapuk, North Jakarta, Indonesia. [Wisudarti, C.] Sardjito Hosp, Yogyakarta, Indonesia. [Maskoen, T.] Sch Med Unpad, Hasan Sadikin Hosp, Bandung, Indonesia. [Hata, N.] Nippon Med Sch, Chiba Hokusoh Hosp, Inzai, Japan. [Kobe, Y.] Chiba Univ Hosp, Chiba, Japan. [Nishida, O.] Fujita Hlth Univ, Sch Med, Toyoake, Aichi, Japan. [Miyazaki, D.] Japanese Red Cross Maebashi Hosp, Maebashi, Gumma, Japan. [Nunomiya, S.] Jichi Med Univ Hosp, Shimotsuke, Japan. [Uchino, S.] Jikei Univ, Sch Med, Tokyo, Japan. [Kitamura, N.] Kimitsu Chuo Hosp, Kisarazu, Japan. [Yamashita, K.] Kochi Med Sch, Nankoku, Kochi, Japan. [Hashimoto, S.] Kyoto Prefectural Univ Med, Kyoto, Japan. [Fukushima, H.] Nara Med Univ Hosp, Kashihara, Nara, Japan. [Adib, N. Nik] Hosp Sultanah Nur Zahirah, Kuala Terengganu, Terengganu, Malaysia. [Tai, L.] Kuala Lumpur Hosp, Kuala Lumpur, Malaysia. [Tony, B.] Queen Elizabeth Hosp 2, Kota Kinabalu, Malaysia. [Bigornia, R.] Cebu Velez Gen Hosp, Cebu, Philippines. [Bigornia, R.] Perpetual Succour Hosp, Cebu, Philippines. [Palo, J.] Med City, Pasig, Philippines. [Chatterjee, S.] Alexandra Hosp, Singapore, Singapore. [Tan, B.] Natl Univ Hlth Syst, Singapore, Singapore. [Kong, A.] Singapore Gen Hosp, Singapore, Singapore. [Goh, S.] Tan Tock Seng Hosp, Singapore, Singapore. [Lee, C.] Natl Taiwan Univ Hosp, Taipei, Taiwan. [Pothirat, C.] Chiaingmai Univ, Maharaj Nakorn Chiangmai Hosp, Chiang Mai, Thailand. [Khwannimit, B.] Prince Songkla Univ, Hat Yai, Thailand. [Theerawit, P.] Ramathibodi Hosp, Bangkok, Thailand. [Pornsuriyasak, P.] Ramathibodi Hosp, Somdech Phra Debaratana Med Ctr, Bangkok, Thailand. [Piriyapatsom, A.] Mahidol Univ, Siriraj Hosp, Bangkok, Thailand. [Mukhtar, A.] Cairo Univ, Giza, Egypt. [Dsicu] Demerdash Surg Intens Care Unit, Cairo, Egypt. [Hamdy, A. Nabil] Ain Shams Fac Med, Cairo, Egypt. [Hosny, H.] Zaitoun Specialized Hosp, Cairo, Egypt. [Ashraf, A.] Gums, Tehran, Iran. [Mokhtari, M.] Sbums, Imam Hossein Hosp, Tehran, Iran. [Nowruzinia, S.] Imamreza Hosp, Mashhad, Razavi Khorasan, Iran. [Lotfi, A.] Laleh Hosp, Tehran, Iran. [Zand, F.] Shiraz Anesthesiol & Crit Care Res Ctr, Shiraz, Iran. [Nikandish, R.] Shiraz Univ Med Sci, Shiraz, Iran. [Moghaddam, O. Moradi] Tehran Med Sci Univ, Tehran, Iran. [Cohen, J.] Rabin Med Ctr, Petah Tiqwa, Israel. [Sold, O.] Sourasky Tel Aviv Med Ctr, Tel Aviv, Israel. [Sfeir, T.] Ctr Hosp Nord, Ettelbruck, Luxembourg. [Hasan, A.] Sohar Hosp, Sohar, Oman. [Abugaber, D.] Specialized Arab Hosp, Nablus, Palestine. [Ahmad, H.] Almana Gen Hosp, Khobar, Saudi Arabia. [Tantawy, T.] KFSHRC, Riyadh, Saudi Arabia. [Baharoom, S.] King Abdulaziz Med City Riyadh, Riyadh, Saudi Arabia. [Algethamy, H.] King Abdulaziz Univ, Jeddah, Saudi Arabia. [Amr, A.] King Saud Med City, Riyadh, Saudi Arabia. [Almekhlafi, G.] Riyadh Mil Hosp, Riyadh, Saudi Arabia. [Coskun, R.] Erciyes Univ, Med Fac, Kayseri, Turkey. [Sungur, M.] Erciyes Univ, Med Sch, Kayseri, Turkey. [Cosar, A.] Gulhane Mil Med Acad, Ankara, Turkey. [Gucyetmez, B.] Int Hosp, Istanbul, Turkey. [Demirkiran, O.] Istanbul Univ, Cerrahpasa Med Sch Hosp, Istanbul, Turkey. [Senturk, E.] Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey. [Ulusoy, H.] Karadeniz Tech Univ, Med Fac, Trabzon, Turkey. [Atalan, H.] Mem Atasehir Hosp, Istanbul, Turkey. [Serin, S.] Pamukkale Univ, Denizli, Turkey. [Kati, I] Yuzuncu Yil Univ, Med Fac, Van, Turkey. [Alnassrawi, Z.] Dubai Hosp, Dubai, U Arab Emirates. [Almemari, A.] Mafraq Hosp, Abu Dhabi, U Arab Emirates. [Krishnareddy, K.] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates. [Kashef, S.] Tawam Hosp, Al Ain, U Arab Emirates. [Alsabbah, A.] City Hosp, Dubai, U Arab Emirates. [Poirier, G.] Hop Charles Lemoyne, Longueuil, PQ, Canada. [Marshall, J.] St Michaels Hosp, Toronto, ON, Canada. [Herridge, M.] Toronto Gen Hosp, Toronto, ON, Canada. [Herridge, M.] Toronto Western Hosp, Toronto, ON, Canada. [Fernandez-Medero, R.] San Juan Hosp, San Juan, PR USA. [Fulda, G.] Christiana Care Hlth Syst, Newark, DE USA. [Banschbach, S.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. [Quintero, J.] El Camino Hosp, Mountain View, CA USA. [Schroeder, E.] George Washington Hosp, Washington, DC USA. [Sicoutris, C.] Hosp Univ Penn, Philadelphia, PA 19104 USA. [Gueret, R.] John H Stroger Hosp Cook Cty, Chicago, IL USA. [Kashyap, R.] Mayo Clin, CCM, Rochester, MN USA. [Bauer, P.] Mayo Clin, PCC, Rochester, MN USA. [Nanchal, R.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Wunderink, R.] Northwestern Mem Hosp, Chicago, IL 60611 USA. [Jimenez, E.] Orlando Reg Med Ctr Inc, Orlando, FL USA. [Ryan, A.] Washington Hosp Ctr, Washington, DC 20010 USA. [Ryan, A.] Washington Hosp Ctr, 2H, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 2G, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 3H, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 3G, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, 4H, Washington, DC USA. [Ryan, A.] Washington Hosp Ctr, CVRR, Washington, DC USA. [Prince, D.] Armadale Hlth Serv, Mount Nasura, WA, Australia. [Edington, J.] Bendigo Hosp, Bendigo, Vic, Australia. [Van Haren, F.] Canberra Hosp, Canberra, ACT, Australia. [Bersten, A.] Flinders Med Ctr, Bedford Pk, SA, Australia. [Hawkins, D. J.] Joondalup Hlth Campus, Joondalup, WA, Australia. [Kilminster, M.] Lismore Base Hosp, Lismore, NSW, Australia. [Sturgess, D.] Mater Adult Hosp, South Brisbane, Qld, Australia. [Ziegenfuss, M.] Prince Charles Hosp, Brisbane, Qld, Australia. [O'Connor, S.] Royal Adelaide Hosp, Adelaide, SA, Australia. [Lipman, J.] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia. [Campbell, L.] Royal Darwin Hosp, Tiwi, NT, Australia. [Mcallister, R.] Royal Hobart Hosp, Hobart, Tas, Australia. [Roberts, B.] Sir Charles Gairdner Hosp, Nedlands, WA, Australia. [Williams, P.] Queen Elizabeth Hosp, Woodville, SA, Australia. [Parke, R.] Auckland Dist Hlth Board, Auckland, New Zealand. [Seigne, P.] Christchurch Hosp, Christchurch, New Zealand. [Freebairn, R.] Hawkes Bay Hosp, Hastings, New Zealand. [Nistor, D.] Palmerston North Hosp, Midcent Hlth, Palmerston North, New Zealand. [Oxley, C.] Middlemore Hosp, Auckland, New Zealand. [Young, P.] Wellington Hosp, Wellington, New Zealand. [Valentini, R.] Cemic, Buenos Aires, DF, Argentina. [Wainsztein, N.] Fleni, Buenos Aires, DF, Argentina. [Comignani, P.] Hosp Aleman, Buenos Aires, DF, Argentina. [Casaretto, M.] Hosp Cent San Isidro, Buenos Aires, DF, Argentina. [Sutton, G.] Hosp Fernandez, Buenos Aires, DF, Argentina. [Villegas, P.] Hosp Francisco Lopez Lima Area Programa Gen Roca, Gen Roca, Argentina. [Galletti, C.] Sanatorio Allende, Cordoba, Argentina. [Neira, J.] Sanatorio Trinidad Palermo, Buenos Aires, DF, Argentina. [Rovira, D.] Sanatorio Julio Corzo Rosario, Rosario, Santa Fe, Argentina. [Hidalgo, J.] Karl Heusner Mem Hosp, Belize City, Belize. [Hidalgo, J.] Belize Healthcare Partner, Belize City, Belize. [Sandi, F.] Hosp Obrero 1, La Paz, Bolivia. [Caser, E.] Cias Unimed Vitoria, Vitoria, ES, Brazil. [Thompson, M.] Evangelical Hosp Cachoeiro De Itapemirim, Cachoeiro De Itapemirim, Brazil. [D'agostino Dias, M.] Hosp 9 Julho, Sao Paulo, Brazil. [Fontes, L.] Hosp Alcides Carneiro, Petropolis, Brazil. [Lunardi, M.] Hosp Clin Luzia De Pinho Melo, Mogi Das Cruzes, Brazil. [Youssef, N.] Hosp Nacoes Curitiba, Curitiba, Parana, Brazil. [Lobo, S.] Hosp Base Famerp, Sao Jose Do Rio Preto, Brazil. [Silva, R.] Hosp Clin Niteroi, Niteroi, RJ, Brazil. [Sales Jr, J.] Hosp Clin Padre Miguel, Rio De Janeiro, Brazil. [Madeira Campos Melo, L.] Hosp Terapia Intens, Sao Paulo, Brazil. [Oliveira, M.] Hosp Trabalhador, Curitiba, Parana, Brazil. [Fonte, M.] Hosp Esperanza, Olinda, PE, Brazil. [Grion, C.] Hosp Evangel Londrina, Londrina, Brazil. [Feijo, C.] Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil. [Rezende, V] Hosp Geral Roraima, Boa Vista, Brazil. [Assuncao, M.] Hosp Israelita Albert Einstein, Sao Paulo, Brazil. [Neves, A.] Hosp Mater Dei, Belo Horizonte, MG, Brazil. [Gusman, P.; Dalcomune, D.] Hosp Meridional, Cariacica, ES, Brazil. [Teixeira, C.] Hosp Moinhos Vento, Porto Alegre, RS, Brazil. [Kaefer, K.] Hosp Municipal Ruth Cardoso, Balneario, Brazil. [Maia, I] Hosp Nereu Ramos, Florianopolis, SC, Brazil. [Souza Dantas, V] Hosp Pasteur, Rio De Janeiro, Brazil. [Costa Filho, R.] Hosp Pro Cardiaco, Rio De Janeiro, Brazil. [Amorim, F.] Hosp Reg Samambaia, Brasilia, DF, Brazil. [Assef, M.] Hosp Reg Hans Dieter Schmidt, Joinville, Brazil. [Schiavetto, P.] Hosp Santa Casa Campo Mourao, Campo Mourao, PR, Brazil. [Houly, J.] Hosp Santa Paula, Sao Paulo, SP, Brazil. [Houly, J.] Hosp Santapaula, Sao Paulo, Brazil. [Bianchi, F.] Hosp Sao Jose Avai, Itaperuna, RJ, Brazil. [Dias, F.] Hosp Sao Lucas Pucrs, Porto Alegre, RS, Brazil. [Avila, C.] Hosp Sao Vicente Paula, Rio De Janeiro, RJ, Brazil. [Gomez, J.] Hosp Sao Vicente Paulo, Rio De Janeiro, Brazil. [Rego, L.] Hosp Saude Mulher, Belem, Para, Brazil. [Castro, P.] Hosp Tacchini, Bento Goncalves, RS, Brazil. [Passos, J.] Hosp Unimed Costa Do Sol Macae Rj, Macae, RJ, Brazil. [Mendes, C.] Hosp Univ Ufpb Joao Pessoa, Joao Pessoa, Paraiba, Brazil. [Grion, C.] Hosp Univ Londrina, Londrina, Brazil. [Colozza Mecatti, G.] Hosp Univ Sao Francisco, Braganca Paulista, SP, Brazil. [Ferrreira, M.] Santa Casa Caridade Diamantina, Diamantina, MG, Brazil. [Irineu, V] Santa Casa Misericordia Tatui, Tatui, Brazil. [Guerreiro, M.] Sao Francisco de Paula Hosp, Sao Francisco De Paula, RS, Brazil. [Ugarte, S.] Clin Indisa, Providencia, Chile. [Tomicic, V] Clin Las Lilas, Providencia, Chile. [Godoy, C.] Hosp Carlos Van Buren, Valparaiso, Chile. [Samaniego, W.] Hosp Trabajador Santiago, Santiago, Chile. [Escamilla, I] Hosp El Pino, San Bernardo, Chile. [Escamilla, I] Hosp Mutual De Seguridad, Santiago, Chile. [Castro Castro, L.] Ctr Med Imbanaco, Valle Del Cauca, Colombia. [Libreros Duque, G.] Clin Colombia Cali, Cali, Colombia. [Diaz-Guio, D.] Clin Del Cafe, Armenia, Colombia. [Benitez, F.] Clin La Estancia SA, Popayan, Colombia. [Guerra Urrego, A.] Clin Medellin, Medellin, Colombia. [Buitrago, R.] Fdn Clin Shaio, Bogota, Colombia. [Ortiz, G.] Hosp Santa Clara, Bogota, Colombia. [Villalba Gaviria, M.] Hosp Univ Fdn Santa Fe De Bogota, Bogota, Colombia. [Salas, D.] Calderon Guardia Hosp, San Jose, Costa Rica. [Ramirez-Arce, J.] Hosp Dr Rafael Angel Varlderon Guardia Ccss, San Jose, Costa Rica. [Salgado, E.] Clin La Merced, Quito, Ecuador. [Morocho, D.] Hosp Eugenio Espejo, Quito, Ecuador. [Vergara, J.] Hosp Luis Vernaza, Quito, Ecuador. [Chung Sang, M.] Shdug Sistema Hosp Docente De La Univ Guayaquil, Quito, Ecuador. [Orellana-Jimenez, C.] Gen Hosp, San Salvador, El Salvador. [Garrido, L.] Hosp Ctr Med, Guatemala City, Guatemala. [Diaz, O.] Inst Hondureno Seguro Social, La Ceiba, Honduras. [Resiere, D.] Ctr Hosp Univ Ft De France, Fort De France, Martinique, France. [Osorio, C.] Ctr Estatal Cuidados Crit, Salamanca, Mexico. [De La Vega, A.] Ctr Med Nacl 20 Noviembre Issste, Mexico City, DF, Mexico. [Carrillo, R.] Fdn Clin Med Sur, Mexico City, DF, Mexico. [Sanchez, V] Hosp San Jose TEC Monterrey, Monterrey, Mexico. [Villagomez, A.] Hosp 1 Octubre, Issste, Mexico. [Martinez Zubieta, R.] Hosp Espanol Mexico, Mexico City, DF, Mexico. [Sandia, M.] Hosp Gen Ajusco Medio, Mexico City, DF, Mexico. [Zalatiel, M.] Hosp Gen Guadalupe Victoria, Texcoco, Mexico. [Poblano, M.] Hosp Juarez Mexico, Mexico City, DF, Mexico. [Rodriguez Gonzalez, D.] Hosp Civil Guadalajara, Hspitaljuan I Menchaca, Guadalajara, Jalisco, Mexico. [Arrazola, F.; Juan Francisco, L.] Inst Mexicano Seguro Social, Mexico City, DF, Mexico. [Liamendys-Silva, S. A.] Inst Nacl Cancerol, Mexico City, DF, Mexico. [Hernandez, M.] ISSSTE Guerra Moya, Mexico City, DF, Mexico. [Hernandez, M.] Med Ctr ISSEMYM Toluca, Mexico City, DF, Mexico. [Rodriguez Cadena, D.] Mixta, Mexico City, DF, Mexico. [Lopez Islas, I.] Secretaria Salud Dist Fed, Mexico City, DF, Mexico. [Ballesteros Zarzavilla, C.] Hosp Santo Comas, Panama City, Panama. [Matos, A.] Social Secur Hosp, La Chorrera, Panama. [Oyanguren, I] Clin Anglo Amer, Lima, Peru. [Cerna, J.] Essalud, Lima, Peru. [Quispe Sierra, R.] Hosp Nacl Dos De Mayo, Lima, Peru. [Jimenez, R.] Hosp Rebagliati, Lince Dist, Peru. [Castillo, L.] Inst Nacl Enfermedades Neoplas, Surquillo, Peru. [Ocal, R.] Gulhane Med Fac, Istanbul, Turkey. [Sencan, A.] Izmir Ataturk Educ & Res Hosp, Izmir, Turkey. [Gianoni, S. Mareque] CAMS, Montevideo, Uruguay. [Deicas, A.] CASMU, Montevideo, Uruguay. [Hurtado, J.] Hosp Espanol Asse, Montevideo, Uruguay. [Burghi, G.] Hosp Maciel, Montevideo, Uruguay. [Martinelli, A.] Ctr Med Caracas, Caracas, Venezuela. [Von der Osten, I] Hosp Miguel Perez Carreno, Caracas, Venezuela. [Du Maine, C.] MSF Trauma Hosp Kunduz, Kunduz, Afghanistan. [Bhattacharyya, M.] Amri Hosp, Kolkata, India. [Bandyopadhyay, S.] Amri Hosp Salt Lake, Kolkata, W Bengal, India. [Yanamala, S.] Apollo Hosp, Hyderabad, India. [Gopal, P.] Apollo Hosp, Bangalore, Karnataka, India. [Sahu, S.] Apollo Hosp, Bhubaneswar, India. [Ibrahim, M.] Apollo Special Hosp, Chennai, Tamil Nadu, India. [Rathod, D.] Asian Heart Inst, Mumbai, Maharashtra, India. [Mukundan, N.] Baby Mem Hosp Ltd, Calicut, Kerala, India. [Dewan, A.] Batra Hosp & Mrc, New Delhi 110062, India. [Amin, P.] Bombay Hosp Inst Med Sci, Mumbai, Maharashtra, India. [Samavedam, S.] Care Hosp, Hyderabad, India. [Shah, B.] Cims Hosp, Ahmadabad, Gujarat, India. [Gurupal, D.] Columbiaasia Hosp, Mysore, Karnataka, India. [Lahkar, B.] Dispur Hosp, Gauhati, India. [Mandal, A.] Fortis Hosp, Bangalore, Karnataka, India. [Sircar, M.] Fortis Hosp, Noida, India. [Ghosh, S.] Fortis Escorts Hosp, Faridabad, India. [Balasubramani, V] Ganga Med Ctr & Hosp P Ltd, Coimbatore, Tamil Nadu, India. [Kapadia, F.] Hinduja Hosp, Mumbai, Maharashtra, India. [Vadi, S.] KDAH, Mumbai, Maharashtra, India. [Nair, K.] Kerala Inst Med Sci, RMCC, Thiruvananthapuram, Kerala, India. [Tripathy, S.] Kalinga Inst Med Sci, DTEM, Bhubaneswar, Odisha, India. [Nandakumar, S.] Kovai Med Ctr & Hosp, Coimbatore, Tamil Nadu, India. [Sharma, J.] Medanta Medic, Gurgaon, India. [Kar, A.] Med Superspecialty Hosp, Kolkata, W Bengal, India. [Jha, S.] Metro Heart Inst Multispecial, Faridabad, India. [Gurav, K. Zirpe] Ruby Hall Pune, Pune, Maharashtra, India. [Patel, M.] Saifee Hosp, Mumbai, Maharashtra, India. [Bhaysar, A.] Spandan Multispecial Hosp, Vadodara, India. [Samaddar, D.] Tata Main Hosp, Jamshedpur, Jharkhand, India. [Kulkarni, A.] Tata Mem Hosp, Mumbai, Maharashtra, India. [Hashmi, M.] Aga Khan Univ, Karachi, Pakistan. [Ali, W.] Hearts Int Hosp, Rawalpindi, Pakistan. [Nadeem, S.] Liaquat Natl Hosp, Karachi, Pakistan. [Indraratna, K.] Sri Jayewardenepura Gen Hosp, Sri Jayawardenepura Kott, Sri Lanka. [Margarit, A.] Hosp Nostra Senyora Meritxell, Les Escaldes, Andorra. [Urbanek, P.] Akh Wien, Vienna, Austria. [Schlieber, J.] Allgemeines & Orthopad Landeskrankenhaus Stolzalp, Stolzalpe, Austria. [Reisinger, J.] Barmherzige Schwestern Linz, Linz, Austria. [Auer, U.] Gen Hosp Braunau, Braunau, Austria. [Hartjes, A.] Krankenhaus D Barmherzigen Schwestern Ried II, Ried Im Innkreis, Austria. [Lerche, A.] Krankenhaus Floridsdorf, Vienna, Austria. [Janous, T.] LK Gmund Waidhofen Thaya Zwettl, Standort Zwettl, Austria. [Kink, E.] LKH Horgas Enzenbach, Gratwein, Austria. [Krahulec, W.] LKH West, Graz, Austria. [Smolle, K.] Univ Hosp, Graz, Austria. [Van der Schueren, M.] AZ Groeninge Kortrijk, Kortrijk, Belgium. [Thibo, P.] AZ Jan Palfijn Gent, Ghent, Belgium. [Vanhoof, M.] AZ Turnhout, Turnhout, Belgium. [Ahmet, I] Bracops Anderlecht, Anderlecht, Belgium. [Gadisseux, P.] Ctr Hosp Mouscron, Mouscron, Belgium. [Dufaye, P.] CH Peltzer La Tourelle, Verviers, Belgium. [Jacobs, O.] Chirec Edith Cavell, Auderghem, Belgium. [Fraipont, V] CHR Citadelle, Liege, Belgium. [Biston, P.] CHU Charleroi, Charleroi, Belgium. [Dive, A.] CHU Mt Godinne, Yvoir, Belgium. [Bouckaert, Y.] CHU Tivoli, La Louviere, Belgium. [Gilbert, E.] CHwapi, Tournai, Belgium. [Gressens, B.] Clin St Pierre Ottignies, Ottignies, Belgium. [Pinck, E.] Clin Maternite St Elisabeth, Namur, Belgium. [Collin, V] Clin Europe St Michel, Etterbeek, Belgium. [Vincent, J. L.] Erasme Univ Hosp, Anderlecht, Belgium. [De Waele, J.] Ghent Univ Hosp, Ghent, Belgium. [Rimachi, R.] Moliere Hosp, Forest, Belgium. [Gusu, D.] Notre Dame, Brussels, Belgium. [De Decker, K.] Onze Lieve Vrouw Hosp, Aalst, Belgium. [Mandianga, K.] Ixelles Hosp, Ixelles, Belgium. [Heytens, L.] Sint Augustinus, Antwerp, Belgium. [Wittebole, X.] St Luc Univ Hosp UCL, Brussels, Belgium. [Spapen, H.] UZ Brussel, Brussels, Belgium. [Olivier, V] Vivalia Site Libramt, Libramont, Belgium. [Vandenheede, W.] VZW Gezondheidszorg Oostkust Knokke Heist, Knokke Heist, Belgium. [Rogiers, P.] ZNA Middelheim, Antwerp, Belgium. [Kolodzeike, P.] Herning Hosp, Herning, Denmark. [Kruse, M.] Hjoerring Hosp, Hjorring, Denmark. [Andersen, T.] Vejle Hosp, Vejle, Denmark. [Harjola, V] Helsinki Univ Cent Hosp, Helsinki, Finland. [Saarinen, K.] Seinajoki Cent Hosp, Seinajoki, Finland. [Leone, M.] Aix Marseille Univ, Hop Nord, Marseille, France. [Durocher, A.] Calmette Hosp, Lille, France. [Moulront, S.] Ctr Hosp Dunkerque, Dunkerque, France. [Lepape, A.] Ctr Hosp Lyon Sud, Lyon, France. [Losser, M.] CHU Nancy Brabois, Nancy, France. [Cabaret, P.] CH St Philibert, GHICL, Lille, France. [Kalaitzis, E.] CHR Dax, Dax, France. [Zogheib, E.] CHU Amiens, Amiens, France. [Charve, P.] CHU Dijon, Dijon, France. [Francois, B.] CHU Dupuytren, Limoges, France. [Lefrant, J. Y.] CHU Nimes, Nimes, France. [Beilouny, B.] Ctr Hosp Troyes, Troyes, France. [Forceville, X.] Ctr Hosp Meaux, Grp Hosp Est Francilien, Meaux, France. [Misset, B.] Grp Hosp Paris St Joseph, Paris, France. [Jacobs, F.] Hop Antoine Beclere, Clamart, France. [Floccard, B.] Hop Edouard Herriot, Lyon, France. [Payen, D.] Hop Lariboisere, AP HP, Paris, France. [Wynckel, A.] Hop Maison Blanche, Reims, France. [Castelain, V] Hop Univ Strasbourg, Strasbourg, France. [Faure, A.] Hosp Civils Lyon, Lyon, France. [Lavagne, P.] CHU Grenoble, Grenoble, France. [Thierry, I] CHU Nantes, Nantes, France. [Moussa, M.] CHRU Lille, Reanimat Chirurg Cardiovasc, Lille, France. [Vieillard-Baron, A.] Univ Hosp Ambroise Pare, Boulogne, France. [Durand, M.] Univ Hosp Grenoble, La Tronche, France. [Gainnier, M.] Univ Hosp Marseille, Marseille, France. [Ichai, C.] Univ Nice, Nice, France. [Arens, S.] Alexianer Krefeld Gmbh, Krefeld, Germany. [Hoffmann, C.] Charite Hochschulmed Berlin, Berlin, Germany. [Kaffarnik, M.] Charite, Berlin, Germany. [Scharnofske, C.] Diakoniekrankenhaus Henriettenstiftung Gmbh, Hannover, Germany. [Voigt, I] Elisabeth Krankenhaus Essen, Essen, Germany. [Peckelsen, C.] Munich Municipal Hosp Grp, Harlaching Hosp, Munich, Germany. [Weber, M.] Helios St Johannes Klin, Duisburg, Germany. [Gille, J.] Hosp St Georg Leipzig, Leipzig, Germany. [Lange, A.] Klin Hennigsdorf Oberhavel Kliniken Gmbh, Hennigsdorf, Germany. [Schoser, G.] Klin Tettnang, Tettnang, Germany. [Sablotzki, A.] Klinikum St Georg Leipzig, Leipzig, Germany. [Jaschinski, U.; Bluethgen, A.] Klinikum Augsburg, Augsburg, Germany. [Vogel, F.] Klinikum Bremen Mitte, Bremen, Germany. [Tscheu, A.] Klinikum Bremen Ost, Bremen, Germany. [Fuchs, T.] Klinikum Heidenheim, Heidenheim, Germany. [Wattenberg, M.] Klinikum Links Weser Gmbh, Bremen, Germany. [Helmes, T.] Klinikum Luedenscheid, Luedenscheid, Germany. [Scieszka, S.] Krankenhaus Neuwerk, Monchengladbach, Germany. [Heintz, M.] Marienkrankenhaus Schwerte, Schwerte, Germany. [Sakka, S.] Med Ctr Cologne Merheim, Cologne, Germany. [Kohler, J.] Schwarzwald Baar Klinikum Villingen Schwenningen, Villingen Schwenningen, Germany. [Fiedler, F.] St Elisabeth Krankenhaus Koln Hohenlind, Cologne, Germany. [Danz, M.] St Martinus Hosp Olpe, Olpe, Germany. [Sakr, Y.] Uniklinikum Jena, Jena, Germany. [Riessen, R.] Univ Klinikum Tubingen, Tubingen, Germany. [Kerz, T.] Univ Med Mainz, Mainz, Germany. [Kersten, A.] Univ Hosp Aachen, CPACC, Aachen, Germany. [Tacke, F.] Univ Hosp Aachen, DMIII, Aachen, Germany. [Marx, G.] Univ Hosp Aachen, OIC, Aachen, Germany. [Volkert, T.] Univ Hosp Muenster, Munster, Germany. [Schmutz, A.] Univ Med Ctr Freiburg, Freiburg, Germany. [Nierhaus, A.; Kluge, S.] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany. [Abel, P.] Univ Med Greifswald, Greifswald, Germany. [Janosi, R.] Univ Duisburg Essen, Essen, Germany. [Utzolino, S.] Univ Freiburg, Freiburg, Germany. [Bracht, H.] Univ Clin Ulm, Ulm, Germany. [Toussaint, S.] Vivantes Klinikum Neukoelln, Berlin, Germany. [Peftoulidou, M. Giannakou] Ahepa Univ Hosp, Thessaloniki, Greece. [Myrianthefs, P.] Univ Athens, Athens, Greece. [Armaganidis, A.] Univ Athens, Med Sch, Athens, Greece. [Routsi, C.] Evangelismos Med Ctr, Athens, Greece. [Xini, A.] Gen Hosp Chania, Iraklion, Greece. [Mouloudi, E.] Hippokrateion Hosp, Thessaloniki, Greece. [Kokoris, I] Gen Hosp Velos, Volos, Greece. [Kyriazopoulos, G.] Lamia Gen Hosp, Lamia, Greece. [Vlachos, S.] Naval & Vet Hosp, Athens, Greece. [Lavrentieva, A.] Apanikolaou Gen Hosp, Thessaloniki, Greece. [Partala, P.] Univ Hosp Alexandroupolis, Alexandroupolis, Greece. [Nakos, G.] Univ Ioannina, Ioannina, Greece. [Moller, A.] Landspitali Univ Hosp, Reykjavik, Iceland. [Stefansson, S.] Landspitali Univ Hosp Fossvogur, Reykjavik, Iceland. [Barry, J.] Cork Univ Hosp, Cork, Ireland. [O'Leary, R.] Mercy Univ Hosp, Cork, Ireland. [Motherway, C.] Mid Western Reg Hosp Complex, Limerick, Ireland. [Faheem, M.] Midland Reg Hosp Mullingar, Mullingar, Co Westmeath, Ireland. [Dunne, E.] St Vincents Univ Hosp, Dublin, Ireland. [Donnelly, M.] Tallaght Hosp, Dublin, Ireland. [Konrad, T.] Univ Hosp Galway, Galway, Ireland. [Bonora, E.] Anesthesiol & Intens Care, Milan, Italy. [Achilli, C.] AO Osped Niguarda Ca Granda, Milan, Italy. [Rossi, S.] Azienda Osped Padova, Padua, Italy. [Castiglione, G.] Azienda Ospedaliero Univ Policlin Vittorio Emanue, Catania, Italy. [Penis, A.] Careggi Teaching Hosp, Florence, Italy. [Albanese, D.] Clinicized Hosp Ss Annunziata Chieti, Chieti, Italy. [Stocchetti, N.] Fdn Irccs Ca Granda Osped Maggiore Policlin, Milan, Italy. [Stocchetti, N.] Univ Milan, Milan, Italy. [Citerio, G.] H San Gerardo Monza, Monza, Italy. [Mozzoni, L.] Icu Ceccarini Hosp Ricc, Rimini, Italy. [Sisillo, E.] Irccs Ctr Cardiol Monzino, Milan, Italy. [De Negri, P.] Irccs Ctr Riferimento Oncol Basilicata, Basilicata, Italy. [Savioli, M.] Irccs Fdn Ca Granda, Osped Maggiore Policlin, Milan, Italy. [Vecchiarelli, P.] Osped Belcolle Viterbo, Viterbo, Italy. [Puflea, F.; Stankovic, V] Osped Civile Maggiore AOUI Verona, Verona, Italy. [Minoja, G.] Osped Circolo E Fdn Macchi, Varese, Italy. [Montibeller, S.] Osped Trento, Azienda Prov I Servizi Sanitari Prov Autonoma Tre, Trento, Italy. [Calligaro, P.] Osped Orlandi, Bussolengo, Italy. [Sorrentino, R.] Osped Regionale U Parini Aosta, Aosta, Italy. [Feri, M.] Osped San Donato Arezzo, Arezzo, Italy. [Zambon, M.] Osped San Raffaele, Segrate, Italy. [Colombaroli, E.] Policlin GB Rossi AOUI Verona, Verona, Italy. [Giarratano, A.] Policlin Univ Palermo, Palermo, Italy. [Pellis, T.] Santa Maria Angeli Hosp, Rome, Italy. [Capra, C.] Saronno Hosp, Saronno, Italy. [Antonelli, M.] Univ Cattolica Sacro Cuore, Milan, Italy. [Gullo, A.] Univ Catania, Catania, Italy. [Chelazzi, C.] Univ Florence, Florence, Italy. [De Capraris, A.] Univ Foggia, Foggia, Italy. [Patroniti, N.] Univ Milano Bicocca, San Gerardo Hosp, Milan, Italy. [Girardis, M.] Univ Modena, Modena, Italy. [Franchi, F.] Univ Siena, Siena, Italy. [Berlot, G.] Univ Trieste, Trieste, Italy. [Buttigieg, M.] Mater Hosp, Msida, Malta. [Ponssen, H.] Albert Schweitzer Hosp, Dordrecht, Netherlands. [Cate, J. Ten] Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, Netherlands. [Bormans, L.] Atrium Med Ctr Parkstad, Heerlen, Netherlands. [Husada, S.] Bovenij Hosp, Amsterdam, Netherlands. [Buise, M.] Catharina Hosp, Eindhoven, Netherlands. [Van Der Hoven, B.] Erasmus MC, Rotterdam, Netherlands. [Reidinga, A.] Martiniziekenhuis Groningen, Groningen, Netherlands. [Kuiper, M.] Med Ctr Leeuwarden, Leeuwarden, Netherlands. [Pickkers, P.] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands. [Kluge, G.] Slotervaart Ziekenhuis Amsterdam, Amsterdam, Netherlands. [Den Boer, S.] Spaarne Ziekenhuis, Hoofddrop, Netherlands. [Kesecioglu, J.] Univ Med Ctr Utrecht, Utrecht, Netherlands. [Van Leeuwen, H.] Ziekenhuis Rijnstate, Arnhem, Netherlands. [Flaatten, H.] Haukeland Hosp, Bergen, Norway. [Mo, S.] Trondheim Reg & Univ Hosp, St Olays Hosp, Trondheim, Norway. [Branco, V] Ctr Hosp Cova Da Beira, Covilha, Portugal. [Rua, F.] Ctr Hosp Porto, Porto, Portugal. [Lafuente, E.] Ctr Hosp Tamega E Sousa, Guilhufe, Portugal. [Sousa, M.] Ctr Hosp Gaia Espinho, Epe, Espinho, Portugal. [Catorze, N.] Ctr Hosp Medio Tejo, Lisbon, Portugal. [Barros, M.] Ctr Hosp Tondela Viseu, Viseu, Portugal. [Pereira, L.] Faro Hosp, Faro, Portugal. [De Oliveira, A. Vintern] Hosp Curry Cabral, Lisbon, Portugal. [Gomes, J.] Hosp Luz, Lisbon, Portugal. [Gaspar, I] Hosp Egas Moniz Chlo, Lisbon, Portugal. [Pereira, M.] Ctr Hosp Porto, Hosp Santo Antonio, Proto, Portugal. [Cymbron, M.] Hosp Divino Espirito Santo, Epe, Ponta Delgada, Portugal. [Dias, A.] Hosp Espirito Santo Evora Epe, Evora, Portugal. [Almeida, E.] Hosp Garcia Orta, Almada, Portugal. [Beirao, S.] Hosp Geral Ctr Hosp E Univ Coimbra, Coimbra, Portugal. [Serra, I] Hosp Prof Doutor Fernando Fonseca Epe, Amadora, Portugal. [Ribeiro, R.] Hosp Sao Bernardo, Setubal, Portugal. [Povoa, P.] Hosp Sao Francisco Xavier, Chlo, Lisbon, Portugal. [Faria, F.] Inst Portugues Oncol Francisco Gentil, Porto, Portugal. [Costa-E-Silva, Z.] Santa Maria Hosp, Lisbon, Portugal. [Nobrega, A.] Serv Saude Regiao Autonoma Madeira, Funchal, Portugal. [Fernandes, F.] UCIP, Lisbon, Portugal. [Gabriel, J.] ULS Castelo Branco, Castelo Branco, Portugal. [Voga, G.] Gen Hosp Celje, Celje, Slovenia. [Rupnik, E.] Gen Hosp Izola, Izola, Slovenia. [Kosec, L.] Gen Hosp Novo Mesto, Novo Mesto, Slovenia. [Povsic, M. Kerin] Oncol Inst, Ljubljana, Slovenia. [Osojnik, I] Ukc Maribor, Maribor, Slovenia. [Tomic, V] Univ Clin Resp & Allerg Dis, Golnik, Slovenia. [Sinkovic, A.] Univ Clin Ctr Maribor, Maribor, Slovenia. [Gonzalez, J.] CH Salamanca, Salamanca, Spain. [Zavala, E.] Clin Hosp, Barcelona, Spain. [Perez Valenzuela, A.] Complejo Hosp Jaen, Jaen, Spain. [Marina, L.] Complejo Hosp Toledo, Toledo, Spain. [Vidal-Cortes, P.] Complexo Hosp Univ Ourense, Orense, Spain. [Posada, I] Complexo Hosp Univ Vigo, Galicia, Spain. [Ignacio Martin-Loeches, A.] Corp Sanitaria Parc Tauli, Barcelona, Spain. [Munoz Guillen, N.] Cruz Roja Hosp, Seville, Spain. [Palomar, M.] H Vall Hebron, Barcelona, Spain. [Sole-Violan, U.] HGGC Dr Negrin, Madrid, Spain. [Torres, A.] Hosp Clin Barcelona, Barcelona, Spain. [Gonzalez Gallego, M.] Hosp Clin San Carlos, Madrid, Spain. [Aguilar, G.] Hosp Clin Univ Valencia, Valencia, Spain. [Montoiro Allue, R.] Hosp Clin Univ Lozano Blesa, Zaragoza, Spain. [Argueso, M.] Hosp Clin Valencia, Valencia, Spain. [Parejo, M.] Hosp La Ribera, Valencia, Spain. [Palomo Navarro, M.] Hosp Sagunto, Port De Sagunt, Spain. [Jose, A.] Hosp San Juan Alicante, Alicante, Spain. [Nin, N.] Hosp Torrejon de Ardoz, Madrid, Spain. [Alvarez Lerma, F.] Hosp Mar, Barcelona, Spain. [Martinez, O.] Hosp Tajo, Madrid, Spain. [Tenza Lozano, E.] Hosp Gen Univ Elche, Elche, Spain. [Arenal Lopez, S.; Perez Granda, M.] Hosp Gen Univ Gregorio Maranon, Madrid, Spain. [Moreno, S.] Hosp Gen Univ Santa Lucia, Murcia, Spain. [Llubia, C.] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain. [De la Fuente Martos, C.] Hosp Infanta Margarita, Cabra, Spain. [Gonzalez-Arenas, P.] Hosp Infanta Sofia, Madrid, Spain. [Llamas Fernandez, N.; Gil Rueda, B.] Hosp JM Morales Meseguer, Murcia, Spain. [Estruch Pons, I] Hosp Marina Salu Denia Alicante, Alicante, Spain. [Cruza, N.] Hosp Nuestra Senora Prado, Toledo, Spain. [Maroto, F.] Hosp San Juan De Dios Aljarafe, Bormujos, Spain. [Estella, A.] Hosp Sas Jerez, Andalucia, Spain. [Ferrer, A.] Hosp Son Llatzer, Palma De Mallorca, Spain. [Iglesias Fraile, L.; Quindos, B.] Hosp Univ Cent Asturias, Oviedo, Spain. [Quintano, A.] Hosp Univ Alava, Santiago, Spain. [Tebar, M.] Hosp Univ Basurto, Bilbao, Spain. [Cardinal, I] Hosp Univ Getafe, Getafe, Spain. [Reyes, A.] Hosp Univ La Princesa, Madrid, Spain. [Rodriguez, A.] Hosp Univ Tarragona Joan Xxiii, Tarragona, Spain. [Abella, A.] Hosp Univ Henares, Coslada, Spain. [Garcia Del Valle, S.] Hosp Univ Fdn Alcorcon, Alcorcon, Spain. [Yus, S.; Maseda, E.] Hosp Univ La Paz, Madrid, Spain. [Berezo, U.] Hosp Univ Rio Hortega, Valladolid, Spain. [Tejero Pedregosa, A.] Hosp Univ San Cecilio, Granada, Spain. [Laplaza, C.] Hosp Virgen Del Camino, Pamplona, Spain. [Ferrer, R.] Mutua Terrassa Univ Hosp, Terrassa, Spain. [Rico-Feijoo, U.] Rao Hortega Univ Hosp, Valladolid, Spain. [Rodriguez, M.] Serv Andaluz Salud, Andalucia, Spain. [Monedero, P.] Univ Okalingaf Navarra, Navarra, Spain. [Eriksson, K.] Karolinska Univ Hosp, Solna, Sweden. [Eriksson, K.] Karolinska Inst, Solna, Sweden. [Lind, D.] Sunderby Hosp, Lulea, Sweden. [Chabanel, D.] Hop Intercantonal La Broye, Payerne, Switzerland. [Zender, H.] Hop Neuchatelois La Chaux De Fonds, La Chaux De Fonds, Switzerland. [Heer, K.] Lindenhofspital, Bern, Switzerland. [Frankenberger, B.] Regionalspital Surselva Ilanz, Ilanz, Switzerland. [Jakob, S.] Univ Hosp Bern, Bern, Switzerland. [Mathew, S.] Alexandra Hosp Redditch, Redditch, England. [Downes, R.] Blackpool Teaching Hosp, Blackpool, England. [Groba, C. Barrera] Brighton & Sussex Univ Hosp, Brighton, E Sussex, England. [Johnston, A.] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England. [Meacher, R.] Charing Cross Hosp, London, England. [Keays, R.] Chelsea & Westminster Hosp, London, England. [Haji-Michael, P.] Christie Fdn Trust, Manchester, Lancs, England. [Tyler, C.] Cty Hosp, Lincoln, England. [Ferguson, A.] Craigavon Area Hosp, Craigavon, North Ireland. [Jones, S.] Cumberland Infirm, Carlisle, England. [Tyl, D.] Darent Valley Hosp, Dartford, England. [Ball, A.] Dorset Cty Hosp, Dorchester, England. [Vogel, U.] Ealing Hosp NHS Trust, Southall, Middx, England. [Booth, M.] Glasgow Royal Infirm, Glasgow, Lanark, Scotland. [Downie, P.] Gloucester Royal Hosp, Gloucester, England. [Watters, M.] Great Western Hosp, Swindon, Wilts, England. [Brett, S.] Imperial Coll Healthcare NHS Trust, London, England. [Garfield, M.] Ipswich Hosp Nhs Trust, Ipswich, Suffolk, England. [Everett, L.] James Paget Univ Hosp NHS Fdn Trust, Great Yarmouth, Norfolk, England. [Heenen, S.] Kings Coll Hosp London, London, England. [Dhir, S.] Kings Mill Hosp, Sutton In Ashfield, England. [Beardow, Z.] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England. [Mostert, M.] Lewisham Healthcare NHS Trust, London, England. [Brosnan, S.] Luton & Dunstable Hosp NHS Trust, Luton, Beds, England. [Pinto, N.] Medway Maritime Hosp, Gillingham, England. [Harris, S.] Musgrove Pk Hosp, Taunton, Somerset, England. [Summors, A.] Nevill Hall Hosp, Abergavenny, Wales. [Andrew, N.] Pilgrim Hosp, Boston, England. [Rose, A.] Mid Yorkshire NHS Trust, Pinderfields Hosp, Wakefield, England. [Appelboam, R.] Plymouth Hosp Nhs Trust, Plymouth, Devon, England. [Davies, O.] Princess Royal Hosp Telford, Telford, Shrops, England. [Vickers, E.] Royal Bournemouth Hosp, Bournemouth, Dorset, England. [Agarwal, B.] Royal Free Hampstead NHS Fdn Trust, London, England. [Szakmany, T.] Royal Glamorgan Hosp, Llantrisant, Wales. [Wimbush, S.] Royal Hampshire Cty Hosp, Winchester, Hants, England. [Welters, I] Royal Liverpool Univ Hosp, Liverpool, Merseyside, England. [Pearse, R.] Barts Hlth NHS Trust, Royal London Hosp, London, England. [Hollands, R.] Royal Shrewsbury Hosp, Shrewsbury, Salop, England. [Kirk-Bayley, U.] Royal Surrey Cty Hosp, Guildford, Surrey, England. [Fletcher, N.] St Georges Healthcare, London, England. [Bray, B.] Surrey & Sussex Healthcare Trust, Redhill, Surrey, England. [Brealey, D.] Univ Coll Hosp, London, England.
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- 2019
10. IS IL-6 PLASMA CONCENTRATION PREDICTIVE for THE OUTCOME of LIVER TRANSPLANTATION?: 4
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Trunecka, P, Wohl, P, Lanska, V, Kieslichova, E, Spicak, J, and Striz, I
- Published
- 2005
11. DEVASCULARIZATION SURGICAL MODEL of ACUTE LIVER FAILURE in MINI-PIGS: 24
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Ryska, M, Kieslichova, E, Pantoflicek, T, and Ryska, O
- Published
- 2005
12. SIX YEARS OF SINGLE CENTER EXPERIENCE WITH PERORAL ENDOSCOPIC MYOTOMY (POEM)
- Author
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Rabekova, Z, additional, Vackova, Z, additional, Hucl, T, additional, Stirand, P, additional, Spicak, J, additional, Kieslichova, E, additional, Janousek, R, additional, and Martinek, J, additional
- Published
- 2019
- Full Text
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13. Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA
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Benoit, D.D. (Dominique), Jensen, H.I. (H. I.), Malmgren, J. (J.), Metaxa, V. (V.), Reyners, A.K.L. (Anna), Darmon, M. (M.), Rusinova, K. (K.), Talmor, D. (Daniel), Meert, A.P. (A. P.), Cancelliere, L. (L.), Zubek, L. (L.), Maia, P. (P.), Michalsen, A. (A.), Vanheule, S. (S.), Kompanje, E.J.O. (E. J.O.), Decruyenaere, J. (J.), Vandenberghe, S. (S.), Vansteelandt, S. (Stijn), Gadeyne, B. (B.), van Den Bulcke, B. (B.), Azoulay, E. (Elie), Piers, R.D. (Ruth), Spapen, H., van Malderen, M.-C. (Marie-Claire), Opdenacker, G. (Godelieve), Meyfroidt, G. (Geert), Mesotten, D., Wauters, J. (Joost), van Laer, M. (Marie), Wilmer, A. (Alexander), Ceunen, H. (H.), De Laet, I. (Inneke), Jans, A. (Anita), Benoit, D. (Dominique), Oeyen, S. (Sandra), Herck, I. (Ingrid), Bracke, S. (Stephanie), Clauwaert, C. (Charlotte), Meert, A.-P. (Anne-Pascale), Leclercq, N. (Nathalie), Jacques, D. (Devriendt), Philippe, D. (Dechamps), Zykova, I. (Ivana), Malaska, J. (Jan), Schmidt, M. (Matous), Satinsky, I. (Igor), Kieslichova, E. (Eva), Krizova, J. (Jarmila), Janda, R. (Robert), Fortova, M. (Magdalena), Matyas, J. (Jiri), Rusinova, K. (Katerina), Kopecky, O. (Ondrej), Pedersen, C.A.K. (Christian Alves Køhler), Hebsgaard, S. (Stine), Johnsen, R.F.A. (Rikke Frank Aagaard), Hansen, T.C.B. (Tina Charlotte Bitsch), Darmon, M. (Michael), Reuter, D. (Danielle), Mokart, D. (Djamel), Vincent, F. (François), Hartog, C.S. (Christiane), Gretenkort, P. (Peter), Michalsen, A. (Andrej), Kounougeri, A. (Aikaterini), Nanas, S. (Serafim), Papachristou, D. (Despina), Soultati, I. (Ioanna), Lathyris, D. (Dimitrios), Pasakiotou, M. (Marili), Oikonomou, M. (Marina), Elö, G. (Gabor), Szücs, O. (Orsolya), Fogas, J. (János), Bobek, I. (Ilona), Corte, F.D. (Francesco Della), Olivieri, C. (Carlo), Vaschetto, R. (Rosanna), Cancelliere, L. (Laura), Marinangeli, F. (Franco), Pozone, T. (Tullio), Ciccozzi, A. (Alessandra), Schouten, A. (A.), Bruns, M. (Monique), Gerritsen, R.T. (Rik T.), Koopmans, M. (Matty), Kompanje, E.J.O. (Erwin), van Duijn, M.A.J. (Marijtje A. J.), Zijlstra, J.G. (Jan G.), Reyners, A.K. (Anne KL.), Lutisan, J.G. (Johan), Monte, R. (Raquel), Pinho, J.A. (José António), Pimenta, P. (Pedro), Fernandes, P. (Paula), Paixão, A.I. (Ana Isabel), Faria, R. (Rui), Malmgren, J.A. (Johan A.), Andersson, B. (Bertil), Akerman, E. (Eva), Hvarfner, A. (Andreas), Svensson, R. (Robert), Metaxa, V. (Victoria), Mueller, A. (Ariel), Banner-Goodspeed, V. (Valerie), Rickett, D. (Dee), Wilson, M.E. (Michael E.), Hinds, R. (Richard), Benoit, D.D. (Dominique), Jensen, H.I. (H. I.), Malmgren, J. (J.), Metaxa, V. (V.), Reyners, A.K.L. (Anna), Darmon, M. (M.), Rusinova, K. (K.), Talmor, D. (Daniel), Meert, A.P. (A. P.), Cancelliere, L. (L.), Zubek, L. (L.), Maia, P. (P.), Michalsen, A. (A.), Vanheule, S. (S.), Kompanje, E.J.O. (E. J.O.), Decruyenaere, J. (J.), Vandenberghe, S. (S.), Vansteelandt, S. (Stijn), Gadeyne, B. (B.), van Den Bulcke, B. (B.), Azoulay, E. (Elie), Piers, R.D. (Ruth), Spapen, H., van Malderen, M.-C. (Marie-Claire), Opdenacker, G. (Godelieve), Meyfroidt, G. (Geert), Mesotten, D., Wauters, J. (Joost), van Laer, M. (Marie), Wilmer, A. (Alexander), Ceunen, H. (H.), De Laet, I. (Inneke), Jans, A. (Anita), Benoit, D. (Dominique), Oeyen, S. (Sandra), Herck, I. (Ingrid), Bracke, S. (Stephanie), Clauwaert, C. (Charlotte), Meert, A.-P. (Anne-Pascale), Leclercq, N. (Nathalie), Jacques, D. (Devriendt), Philippe, D. (Dechamps), Zykova, I. (Ivana), Malaska, J. (Jan), Schmidt, M. (Matous), Satinsky, I. (Igor), Kieslichova, E. (Eva), Krizova, J. (Jarmila), Janda, R. (Robert), Fortova, M. (Magdalena), Matyas, J. (Jiri), Rusinova, K. (Katerina), Kopecky, O. (Ondrej), Pedersen, C.A.K. (Christian Alves Køhler), Hebsgaard, S. (Stine), Johnsen, R.F.A. (Rikke Frank Aagaard), Hansen, T.C.B. (Tina Charlotte Bitsch), Darmon, M. (Michael), Reuter, D. (Danielle), Mokart, D. (Djamel), Vincent, F. (François), Hartog, C.S. (Christiane), Gretenkort, P. (Peter), Michalsen, A. (Andrej), Kounougeri, A. (Aikaterini), Nanas, S. (Serafim), Papachristou, D. (Despina), Soultati, I. (Ioanna), Lathyris, D. (Dimitrios), Pasakiotou, M. (Marili), Oikonomou, M. (Marina), Elö, G. (Gabor), Szücs, O. (Orsolya), Fogas, J. (János), Bobek, I. (Ilona), Corte, F.D. (Francesco Della), Olivieri, C. (Carlo), Vaschetto, R. (Rosanna), Cancelliere, L. (Laura), Marinangeli, F. (Franco), Pozone, T. (Tullio), Ciccozzi, A. (Alessandra), Schouten, A. (A.), Bruns, M. (Monique), Gerritsen, R.T. (Rik T.), Koopmans, M. (Matty), Kompanje, E.J.O. (Erwin), van Duijn, M.A.J. (Marijtje A. J.), Zijlstra, J.G. (Jan G.), Reyners, A.K. (Anne KL.), Lutisan, J.G. (Johan), Monte, R. (Raquel), Pinho, J.A. (José António), Pimenta, P. (Pedro), Fernandes, P. (Paula), Paixão, A.I. (Ana Isabel), Faria, R. (Rui), Malmgren, J.A. (Johan A.), Andersson, B. (Bertil), Akerman, E. (Eva), Hvarfner, A. (Andreas), Svensson, R. (Robert), Metaxa, V. (Victoria), Mueller, A. (Ariel), Banner-Goodspeed, V. (Valerie), Rickett, D. (Dee), Wilson, M.E. (Michael E.), and Hinds, R. (Richard)
- Abstract
Purpose: Whether the quality of the ethical climate in the intensive care unit (ICU) improves the identification of patients receiving excessive care and affects patient outcomes is unknown. Methods: In this prospective observational study, perceptions of excessive care (PECs) by clinicians working in 68 ICUs in Europe and the USA were collected daily during a 28-day period. The quality of the ethical climate in the ICUs was assessed via a validated questionnaire. We compared the combined endpoint (death, not at home or poor quality of life at 1 year) of patients with PECs and the time from PECs until written treatment-limitation decisions (TLDs) and death across the four climates defined via cluster analysis. Results: Of the 4747 eligible clinicians, 2992 (63%) evaluated the ethical climate in their ICU. Of the 321 and 623 patients not admitted for monitoring only in ICUs with a good (n = 12, 18%) and poor (n = 24, 35%) climate, 36 (11%) and 74 (12%), respectively were identified with PECs by at least two clinicians. Of the 35 and 71 identified patients with an available combined endpoint, 100% (95% CI 90.0–1.00) and 85.9% (75.4–92.0) (P = 0.02) attained that endpoint. The risk of death (HR 1.88, 95% CI 1.20–2.92) or receiving a written TLD (HR 2.32, CI 1.11–4.85) in patients with PECs by at least two clinicians was higher in ICUs with a good climate than in those with a poor one. The differences between ICUs with an average climate, with (n = 12, 18%) or without (n = 20, 29%) nursing involvement at the end of life, and ICUs with a poor climate were less obvious but still in favour of the former. Conclusion: Enhancing the quality of the ethical climate in the ICU may improve both the identification of patients receiving excessive care and the decision-making process at the end of life.
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- 2018
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14. Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit
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Vincent, J. -L., Marshall, J. C., Namendys-Silva, S. A., Francois, B., Martin-Loeches, I., Lipman, J., Reinhart, K., Antonelli, M., Pickkers, P., Njimi, H., Jimenez, E., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, G. V., Adriana, S., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Lee, K., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Shimomura, Y., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. N., Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Herridge, M., Fernandez, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Richards, B., Kilminster, M., Sturgess, D., Ziegenfuss, M., O'Connor, S., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, M. D., Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Melo, L. M., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Costa Filho, R., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, L. C., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Gaviria, M. V., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Francisco, L. J., Hernandez, M., Cadena, D. R., Islas, I. L., Zarzavilla, C. B., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, S. M., Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Von Der Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, D., Lahkar, B., Mandal, A., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Zirpe Gurav, K., Patel, M., Bhavsar, A., Samaddar, D., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., De Waele, J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Lefrant, J., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Bernard, F., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, L., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Jaschinski, U., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. G., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O'Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., De Oliveira, A. V., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gallego, M. G., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Granda, M. P., Moreno, S., Llubia, C., Martos Cde, L., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Brigida, Q., Quintano, A., Tebar, M., Frutos-Vivar, F., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Groba, C. B., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Williams, K., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Service de Réanimation Polyvalente [CHU Limoges], CHU Limoges, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Vincent, J. -L., Marshall, J. C., Namendys-Silva, S. A., Francois, B., Martin-Loeches, I., Lipman, J., Reinhart, K., Antonelli, M., Pickkers, P., Njimi, H., Jimenez, E., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, G. V., Adriana, S., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Lee, K., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Shimomura, Y., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. N., Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Herridge, M., Fernandez, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Richards, B., Kilminster, M., Sturgess, D., Ziegenfuss, M., O'Connor, S., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, M. D., Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Melo, L. M., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Costa Filho, R., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, L. C., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Gaviria, M. V., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Francisco, L. J., Hernandez, M., Cadena, D. R., Islas, I. L., Zarzavilla, C. B., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, S. 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V., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gallego, M. G., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Granda, M. P., Moreno, S., Llubia, C., Martos Cde, L., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Brigida, Q., Quintano, A., Tebar, M., Frutos-Vivar, F., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Groba, C. B., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Williams, K., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Vincent, J, Marshall, J, Ñamendys-Silva, S, François, B, Martin-Loeches, I, Lipman, J, Reinhart, K, Antonelli, M, Pickkers, P, Njimi, H, Jimenez, E, Sakr, Y, GIARRATANO, A, Namendys-Silva, S, Francois, B, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Zbaganu, G, Adriana, S, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Lee, K, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Shimomura, Y, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Mokhtari, M, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Almekhlafi, G, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Herridge, M, Fernandez, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Bauer, P, Nanchal, R, Wunderink, R, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Richards, B, Kilminster, M, Sturgess, D, Ziegenfuss, M, O'Connor, S, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, Dias, M, Fontes, L, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Costa Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Gomez, J, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Francisco, L, Hernandez, M, Cadena, D, Islas, I, Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, D, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe Gurav, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Granda, M, Moreno, S, Llubia, C, Martos Cde, L, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Brigida, Q, Quintano, A, Tebar, M, Frutos-Vivar, F, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Williams, K, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, and Brealey, D
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Critical Illness ,health care facilities, manpower, and services ,Population ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Critical care, european intensive care, icon study ,Comorbidity ,intensive care medicine ,Global Health ,MOF ,sepsis ,critically ill ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,ICON, Intensive Care ,Article ,Sepsis ,Cohort Studies ,Outcome Assessment (Health Care) ,Intensive care ,Outcome Assessment, Health Care ,Epidemiology ,Health care ,Settore MED/41 - ANESTESIOLOGIA ,medicine ,Global health ,critical illness, mortality ,Humans ,Hospital Mortality ,education ,Intensive care medicine ,education.field_of_study ,Medical Audit ,business.industry ,Intensive Care ,medicine.disease ,3. Good health ,Intensive Care Units ,ICON ,business ,Cohort study - Abstract
Item does not contain fulltext BACKGROUND: Global epidemiological data regarding outcomes for patients in intensive care units (ICUs) are scarce, but are important in understanding the worldwide burden of critical illness. We, therefore, did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of ICU mortality. METHODS: 730 participating centres in 84 countries prospectively collected data on all adult (>16 years) patients admitted to their ICU between May 8 and May 18, 2012, except those admitted for fewer than 24 h for routine postoperative monitoring. Participation was voluntary. Data were collected daily for a maximum of 28 days in the ICU and patients were followed up for outcome data until death or hospital discharge. In-hospital death was analysed using multilevel logistic regression with three levels: patient, hospital, and country. FINDINGS: 10,069 patients were included from ICUs in Europe (5445 patients; 54.1%), Asia (1928; 19.2%), the Americas (1723; 17.1%), Oceania (439; 4.4%), the Middle East (393; 3.9%), and Africa (141; 1.4%). Overall, 2973 patients (29.5%) had sepsis on admission or during the ICU stay. ICU mortality rates were 16.2% (95% CI 15.5-16.9) across the whole population and 25.8% (24.2-27.4) in patients with sepsis. Hospital mortality rates were 22.4% (21.6-23.2) in the whole population and 35.3% (33.5-37.1) in patients with sepsis. Using a multilevel analysis, the unconditional model suggested significant between-country variations (var=0.19, p=0.002) and between-hospital variations (var=0.43, p
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- 2014
15. Liver transplantation using grafts from donors after circulatory death - the first Czech Republic experience.
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Fronek, J., Novotny, R., Kucera, M., Mendl, J., Kocik, M., Trunecka, P., Taimr, P., Kieslichova, E., Pokorna, E., and Janousek, L.
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- 2020
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16. Per-oral endoscopic pyloromyotomy (g-poem) for the treatment of gastroparesis -- a pilot single-centre study with mid-term follow-up.
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Hustak, R., Vackova, Z., Krajciova, J., Janicko, M., Buncova, M., Kieslichova, E., Spicak, J., and Martinek, J.
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- 2020
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17. Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome
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Kieslichova, E., primary, Frankova, S., additional, Protus, M., additional, Merta, D., additional, Uchytilova, E., additional, Fronek, J., additional, and Sperl, J., additional
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- 2018
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18. Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit
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Vincent, J, Marshall, J, Namendys-Silva, S, Francois, B, Martin-Loeches, I, Lipman, J, Reinhart, K, Antonelli, M, Pickkers, P, Njimi, H, Jimenez, E, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Zbaganu, G, Adriana, S, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Lee, K, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Shimomura, Y, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Mokhtari, M, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Almekhlafi, G, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Herridge, M, Fernandez, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Bauer, P, Nanchal, R, Wunderink, R, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Richards, B, Kilminster, M, Sturgess, D, Ziegenfuss, M, O'Connor, S, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, Dias, M, Fontes, L, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Costa Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Gomez, J, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Francisco, L, Hernandez, M, Cadena, D, Islas, I, Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, D, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe Gurav, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Granda, M, Moreno, S, Llubia, C, Martos Cde, L, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Brigida, Q, Quintano, A, Tebar, M, Frutos-Vivar, F, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Williams, K, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Vincent J. -L., Marshall J. C., Namendys-Silva S. A., Francois B., Martin-Loeches I., Lipman J., Reinhart K., Antonelli M., Pickkers P., Njimi H., Jimenez E., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Zbaganu G. V., Adriana S., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X., Zhao X., Li C., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Lee K., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W., Sin K., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T., Hata N., Kobe Y., Shimomura Y., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. N., Tai L., Tony B., Bigornia R., Palo J., Chatterjee S., Tan B., Kong A., Goh S., Lee C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Mokhtari M., Nowruzinia S., Lotfi A., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Herridge M., Fernandez R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Richards B., Kilminster M., Sturgess D., Ziegenfuss M., O'Connor S., Campbell L., Mcallister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M., Dias M. D., Fontes L., Lunardi M., Youssef N., Lobo S., Silva R., Sales J., Melo L. M., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Costa Filho R., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Gomez J., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro L. C., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Gaviria M. V., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Francisco L. J., Hernandez M., Cadena D. R., Islas I. L., Zarzavilla C. B., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal D., Lahkar B., Mandal A., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe Gurav K., Patel M., Bhavsar A., Samaddar D., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Lefrant J., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gallego M. G., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Granda M. P., Moreno S., Llubia C., Martos Cde L., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Brigida Q., Quintano A., Tebar M., Frutos-Vivar F., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Williams K., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Vincent, J, Marshall, J, Namendys-Silva, S, Francois, B, Martin-Loeches, I, Lipman, J, Reinhart, K, Antonelli, M, Pickkers, P, Njimi, H, Jimenez, E, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Zbaganu, G, Adriana, S, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Lee, K, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Shimomura, Y, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Mokhtari, M, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Almekhlafi, G, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Herridge, M, Fernandez, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Bauer, P, Nanchal, R, Wunderink, R, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Richards, B, Kilminster, M, Sturgess, D, Ziegenfuss, M, O'Connor, S, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, Dias, M, Fontes, L, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Costa Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Gomez, J, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Francisco, L, Hernandez, M, Cadena, D, Islas, I, Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, D, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe Gurav, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Philippe, G, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Herbert, S, Olivier, V, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Leone, M, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Bernard, F, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Thierry, L, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Jaschinski, U, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Granda, M, Moreno, S, Llubia, C, Martos Cde, L, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Brigida, Q, Quintano, A, Tebar, M, Frutos-Vivar, F, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Jakob, S, Haller, A, Mathew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Ferguson, A, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Andrew, N, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Williams, K, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Vincent J. -L., Marshall J. C., Namendys-Silva S. A., Francois B., Martin-Loeches I., Lipman J., Reinhart K., Antonelli M., Pickkers P., Njimi H., Jimenez E., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M., Nica A., Stoica R., Tomescu D., Constantinescu D., Zbaganu G. V., Adriana S., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X., Zhao X., Li C., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Lee K., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W., Sin K., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T., Hata N., Kobe Y., Shimomura Y., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. N., Tai L., Tony B., Bigornia R., Palo J., Chatterjee S., Tan B., Kong A., Goh S., Lee C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Mokhtari M., Nowruzinia S., Lotfi A., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Herridge M., Fernandez R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Richards B., Kilminster M., Sturgess D., Ziegenfuss M., O'Connor S., Campbell L., Mcallister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M., Dias M. D., Fontes L., Lunardi M., Youssef N., Lobo S., Silva R., Sales J., Melo L. M., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Costa Filho R., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Gomez J., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro L. C., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Gaviria M. V., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Francisco L. J., Hernandez M., Cadena D. R., Islas I. L., Zarzavilla C. B., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal D., Lahkar B., Mandal A., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe Gurav K., Patel M., Bhavsar A., Samaddar D., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Philippe G., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Herbert S., Olivier V., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V., Saarinen K., Leone M., Durocher A., Moulront S., Lepape A., Losser M., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Lefrant J., Beilouny B., Forceville X., Misset B., Jacobs F., Bernard F., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Thierry L., Moussa M., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Jaschinski U., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S., Barry J., O'Leary R., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gallego M. G., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Granda M. P., Moreno S., Llubia C., Martos Cde L., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Brigida Q., Quintano A., Tebar M., Frutos-Vivar F., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Mathew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Ferguson A., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Andrew N., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Williams K., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., and Brealey D.
- Abstract
Background: Global epidemiological data regarding outcomes for patients in intensive care units (ICUs) are scarce, but are important in understanding the worldwide burden of critical illness. We, therefore, did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of ICU mortality. Methods: 730 participating centres in 84 countries prospectively collected data on all adult (>16 years) patients admitted to their ICU between May 8 and May 18, 2012, except those admitted for fewer than 24 h for routine postoperative monitoring. Participation was voluntary. Data were collected daily for a maximum of 28 days in the ICU and patients were followed up for outcome data until death or hospital discharge. In-hospital death was analysed using multilevel logistic regression with three levels: patient, hospital, and country. Findings: 10 069 patients were included from ICUs in Europe (5445 patients; 54·1%), Asia (1928; 19·2%), the Americas (1723; 17·1%), Oceania (439; 4·4%), the Middle East (393; 3·9%), and Africa (141; 1·4%). Overall, 2973 patients (29·5%) had sepsis on admission or during the ICU stay. ICU mortality rates were 16·2% (95% CI 15·5-16·9) across the whole population and 25·8% (24·2-27·4) in patients with sepsis. Hospital mortality rates were 22·4% (21·6-23·2) in the whole population and 35·3% (33·5-37·1) in patients with sepsis. Using a multilevel analysis, the unconditional model suggested significant between-country variations (var=0·19, p=0·002) and between-hospital variations (var=0·43, p<0·0001) in the individual risk of in-hospital death. There was a stepwise increase in the adjusted risk of in-hospital death according to decrease in global national income. Interpretation: This large database highlights that sepsis remains a major health problem worldwide, associated with high mortality rates in all countries. Our findings also show a significant association between the risk of death and the gl
- Published
- 2014
19. Lack of Impact of Hyperchloremia in Brain-Dead Organ Donors on the Onset of Kidney Allograft Function in the Recipients
- Author
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Uchytilova, E., primary, Protus, M., additional, Merta, D., additional, Kula, R., additional, Pokorna, E., additional, and Kieslichova, E., additional
- Published
- 2017
- Full Text
- View/download PDF
20. General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial
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GALA Trial Collaborative Group, C Lewis, S, P Warlow, C, R Bodenham, A, Colam, B, M Rothwell, P, Torgerson, D, Dellagrammaticas, D, Horrocks, M, Liapis, C, P Banning, A, Gough, M, J Gough, M, Fraser, A, Grant, S, Hunter, J, Leigh-Brown, A, Paterson, M, Soosay, V, Young, A, Williamson, A, Dean, Z, Mazzoli, T, Ricci, S, Valenti, D, Bamford, J, Beard, J, Dearden, M, Murray, G, Ruckley, V, E Norman, P, Sedivy, P, Idla, A, Schmitz-Rixen, T, Maritati, G, Bodenham, A, Cokic, N, Doppler, W, Hlatky, P, Koelblinger, C, Raith, C, Zölss, C, Dimmitt, S, Gharbi, R, Hankey, G, Maden, A, P Mwipatayi, B, Sieunarine, K, Tan, A, Turner, G, Wesseldine, A, T M, E Davis, Audzei, P, Davidovski, I, Dedul, D, Hetsiuk, A, Kornievich, S, Gao, J, Y-G, Huang, Jing, G, H, Li, Y-J, Li, Liu, B, C-W, Liu, J-D, Wu, W, Ye, C-H, Yu, Ban, T, Buljan, K, Candrlic, K, Dapic, D, Ilijasevic, M, Istvanic, T, Kovac, B, Kvolik, S, Lehner, V, Pinotic, K, Hudorović, N, Ivanec, Z, Lovricević, I, Mazul-Sunko, B, Novotny, Z, D De Syo, Vuković, V, Biebl, O, Dolecek, L, C El Samman, Kalasova, H, Kubricht, V, Matous, P, Michalek, P, Stajnrt, M, Stern, M, Svec, M, Vitasek, P, Vrzal, J, Weiss, K, Janousek, L, Kieslichova, E, Mazarova, V, Piza, P, Vychodil, P, Dulovcova, V, Fiksa, J, Hruby, J, Maresch, M, Mathias, M, Rubes, D, Tosenovsky, P, Vidim, T, Henzl, M, Riman, J, Ziegler, Z, Drabek, P, Hrbac, T, Reguli, S, Stigler, J, Bachleda, P, Drac, P, Hudecek, M, Koutna, J, Sanak, D, Utikal, P, Goldemund, D, Gregor, Z, Pavlikova, J, Podlaha, J, Privara, M, Staffa, R, Vlachovsky, R, Barankova, L, Chlouba, V, Fiedler, J, Prazak, P, Priban, V, Wierer, A, Ellervee, T, Järve, H, Sell, A, Taba, P, Kolbassov, V, Kullamaa, S, Paavel, T, Abramishvili, N, Bokuchava, M, Kachapuridze, N, Kipiani, K, Papashvili, K, Pargalava, N, Adili, F, Dietz, A, Neidhart, G, Nentwig, G, M Sitzer, O, Beno, M, Essink-Hassels, M, Lander, K, Ruemenapf, G, Breuer, P, Heldt, R, Melichar, G, Rieper, J, H Eckstein, H, Poppert, H, Schneider, G, Andrikopoulos, V, Angel, A, Bakogiannis, K, Dermitzaki, M, Georgakis, P, Lioupis, C, Maras, D, G Moulakakis, K, Sfyroeras, G, Arato, E, Gyevnar, Z, Hardi, P, Kasza, G, Kollar, L, Menyhei, G, Pal, E, Sinay, L, Verzar, Z, Volgyi, E, S Elmakias, S, Harah, E, Kristal, K, Lebi, D, Leonty, Y, Levy, D, Milo, R, Yoffe, B, Bissi, M, Cappellini, B, Cassamali, T, Corino, L, Denkewitz, T, Ghilardi, G, Massetto, N, P Di Mauro, Tommasino, C, Bartolucci, R, Buffa, V, M Corsi, F, D'Avino, E, F Di Cesare, L Di Pirro, Lappa, A, Luzzi, S, Menichetti, A, Nesi, F, Pannone, A, Picozzi, P, Pogany, G, Rabitti, G, Severi, L, Avella, R, Biandolino, P, P Giomarelli, P, R Monfregola, M, Palasciano, G, Peccianti, V, Pieragalli, D, Setacci, C, Setacci, F, Sirignano, P, Bordoni, M, Casadei, V, Cugnasca, M, A De Troia, Geremia, L, Guffanti, P, G Lo Guercio, V Maniaci, M, Mauri, Morbidelli, A, Aletta, A, Costanzo, E, D'Arrigo, G, F Di Stefano, Lomeo, A, Maugeri, S, C Monea, M, Scardavilli, G, Scolaro, A, Aloisi, P, Ciccozzi, A, Manno, M, Marrelli, A, Martinazzo, C, Mastromarino, A, Petrassi, C, Piroli, A, Spartera, C, Ventura, M, Alessandrini, F, Carissimi, C, M Centritto, E, Cinelli, G, C De Filippo, Liberatoscioli, G, Modugno, P, Rossi, M, T Attanzio, M, Bajardi, G, Bellisi, M, Machi, P, Salemi, S, Savettieri, G, A Crea, M, V di Lazzaro, Ferrante, A, Guarneri, S, Manni, R, Snider, F, Stefanuto, C, Berardi, G, Bianchi, A, Comis, M, Cumbo, P, Fadde, M, Ferrero, E, Ferri, M, Filardo, A, Gaggiano, A, Ganzaroli, M, Labate, C, Maggio, D, Mennuti, G, Minicucci, S, Musso, A, Nessi, F, Pasquino, M, Perretta, L, Piazza, S, Verdecchia, C, Viazzo, A, Antico, A, Battan, E, Ciarlo, M, Giardini, G, G Luca Iob, Marinello, C, Piccolo, D, Bove, R, Castrucci, T, Lorido, A, Sammarco, S, Bruzzone, B, Cannata, D, Colotto, P, Finocchi, C, Giudici, N, Mambrini, S, Mazzei, R, Palombo, D, Pellegrino, A, Rousas, N, Viacava, A, Ermirio, D, Faga, D, Simoni, G, Benedetti-Valentini, F, Gabrielli, R, Garofano, R, Gossetti, B, Guerricchio, R, Irace, L, Lenzi, G, Gedins, M, Kisis, K, Krievins, D, Krustina, I, Lietuvietis, E, Malina, M, Morlata, N, Rits, J, Thor, S, Ivanova, P, Kikule, I, Liepa, V, Ligers, A, Stengrevica, N, Vnukova, N, Zvirgzdins, V, P J A, M Brouwers, H Geelkerken, R, Stam, A, M A, M Simon, T den Hoed, P, Oltmans, M, Rettig, H, F Veen, H, Zuidgeest, D, Feldo, M, Kesik, J, Kobusiewicz, W, Łatkiewicz, D, Myślinski, W, Przywara, S, Terlecki, P, Wroński, J, Zubilewicz, T, Alfonso, G, Azevedo, E, R de Albuquerque, Mansilha, A, Al-Salman, M, K Aldaif, A, A Alnasr, T, A El Dawlatly, A, Elkayali, A, M Rabee, H, Chudikova, E, Chudá, I, Dulka, T, Goldenberg, Z, Lofaj, P, Pavlikova, M, Pisar, M, Sefranek, V, Slysko, R, Tomka, J, Tóthová, Z, Zita, Z, A Cairols, M, Iborra, E, Mercadal, M, Rubio, F, Canovas, D, Cobo, L, Gimenez-Gaibar, A, Gonzalez, E, Gonzalo, B, Guilera, N, Hospedales, J, J Laso, M, Perez, J, Solanich, T, Hensater, M, Karlström, L, Kjällman, L, Rosengren, L, C-A, Ewaldsson, Gillgren, P, T-B, Käll, Konrad, P, Lindkvist, M, Nilsson, L, Takolander, R, E von Zweigbergk, Cinar, B, Coruh, T, Kurc, E, Ozsoy, D, Sargin, M, Tutkavul, K, Yekeler, I, Aksoy, M, Aksoy, S, Kurtoglu, M, Arar, C, Canbaz, S, Celik, Y, Ege, T, Ketenc, S, Sunar, H, Unal, S, Asik, I, Bengisun, U, Koksoy, C, Yucemen, N, C Berridge, D, Caldicott, L, Cooper, J, Cross, M, Ford, H, Fuller, R, Gamlin, F, Homer-Vanniasinkum, S, Howell, S, Kent, P, Lumb, A, A I, D Mavor, D J, A Scott, Shah, M, Wanklyn, P, S Budd, J, Mcateer, P, Shaw, L, Dewar, R, H Lewis, M, Potter, C, Richards, H, Roberts, R, Townsend, E, Wagle, A, Woodford, P, Hall, G, Holdsworth, R, Macleod, M, Michels, L, P A, G Sandercock, Sudlow, C, Woods, A, S Abraham, J, Bukhari, M, Bush, A, Calvey, J, Chadwick, I, Krishnaprasad, K, Oldham, T, Tomlinson, M, Vickers, A, Wilson, D, Wilson, P, Greystone, S, C Grocott, E, Hayes, W, Haynes, S, Jenkins, C, Jenkins, D, Moore, W, Nyamekye, I, Overstall, P, Riseboro, S, Williams, H, Boyle, J, Duane, D, Gaunt, M, J Kirkpatrick, P, Martin, P, E Risdall, J, Scurrah, N, L Turner, C, Varty, K, T Ferguson, I, Horsfall, S, C Mitchell, D, Robinson, S, Frankel, J, E Morris, G, Phillips, M, Sansome, A, J Sparkes, D, Williams, J, Ashton, W, Baker, S, Clark, M, G Darke, S, Dunnill, R, Hargreaves, M, Jenkinson, D, Thomson, C, White, N, D Wijesinghe, L, Bapat, P, A Barrett, J, D Blair, S, Chandrasekar, R, Lawrence, G, Lowe, D, Sangster, G, Smith, M, M Van Miert, K Das, S, Malik, O, Nel, M, Rakowicz, W, Aukett, M, Carmichael, M, Colchester, A, R Taylor, P, Wood, C, Ageed, A, J Boom, S, Ghosh, S, Godfrey, J, Hewitt-Gray, J, Mcdiarmid, I, Yousif, S, Ziarkowski, A, Al-Din, A, Carpenter, M, Ch'Ng, K, J Curley, P, Davey, R, Henderson, B, F Hossain, J, D Irvine, C, Loizou, L, Main, A, Stanners, A, Muldoon, T, V Soong, C, Wiggam, I, P Armon, M, Burrows, M, Holmes, L, K Metcalf, A, Nunn, D, Abdul-Hamid, A, Akomalafe, B, Bryce, J, Chetter, I, Samaan, A, Briley, D, Collin, J, Darby, C, Dobson, M, Foex, P, Grange, C, Handa, A, Hands, L, E Higham, H, J M, T Perkins, Sear, J, Stoneham, M, Hamilton, G, Judge, C, Morris-Vincent, P, Pegg, M, A Wilson, L, I Aldoori, M, B E, A Dafalla, Kumar, N, I F, C Hay, Jefferson, P, Muir, I, Peel, W, Rutherford, J, Sathianathan, J, Wight, S, Williams, D, Wrathall, W, Bachoo, P, Brittenden, J, Counsell, C, Patey, R, Read, J, L de Cossart, K Dimitri, S, Edwards, P, Fergusson, N, Jameson, P, Somauroo, J, Taylor, V, D Aravindan, P, Brocklehurst, I, Mirza, S, N Namushi, R, O Oshodi, T, Ruff, D, A Solomon, S, Vassallo, J, Egbe, M, Halstead, G, Onwudike, M, Putland, A, Roberts, N, A Salaman, R, Watson, D, Caine, S, Day, J, Lamont, P, J Murphy, P, Smith, F, Beacham, K, J Dorman, P, Lambert, D, Rodgers, H, Collas, D, Sarin, S, Shah, J, S Baht, H, Banks, J, Cowie, L, Gunathilagan, G, Hargroves, D, Insall, R, G Smithard, D, K Chadha, D, R Pillay, W, Rashid, J, Sayles, J, Hill, S, Lawton, G, M Lloyd, C, Marsh, A, Clarke, G, J Lonsdale, R, Venables, G, Cross, R, Lord, B, Mcilmoyle, J, Y Osman, H, Robinson, J, Chant, H, Mate, A, Sim, D, Upton, P, Thomas, D, H Wolfe, J, Mccollum, C, O'Neill, P, Bernatsky, V, Bondar, L, Karpenko, A, Mamonova, M, Muz, N, and Yavorsky, V
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Carotid endarterectomy ,general anesthesia ,local anesthesia ,carotid surgery ,Anesthesia, General ,law.invention ,Postoperative Complications ,Randomized controlled trial ,law ,medicine ,Humans ,Carotid Stenosis ,General anaesthesia ,general anaesthesia ,Stroke ,Aged ,Endarterectomy ,Endarterectomy, Carotid ,local anaesthesia ,Intention-to-treat analysis ,business.industry ,General Medicine ,Perioperative ,Vascular surgery ,medicine.disease ,Surgery ,Anesthesia ,Female ,business ,Anesthesia, Local - Abstract
BACKGROUND: The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia. METHODS: We undertook a parallel group, multicentre, randomised controlled trial of 3526 patients with symptomatic or asymptomatic carotid stenosis from 95 centres in 24 countries. Participants were randomly assigned to surgery under general (n=1753) or local (n=1773) anaesthesia between June, 1999 and October, 2007. The primary outcome was the proportion of patients with stroke (including retinal infarction), myocardial infarction, or death between randomisation and 30 days after surgery. Analysis was by intention to treat. The trial is registered with Current Control Trials number ISRCTN00525237. FINDINGS: A primary outcome occurred in 84 (4.8%) patients assigned to surgery under general anaesthesia and 80 (4.5%) of those assigned to surgery under local anaesthesia; three events per 1000 treated were prevented with local anaesthesia (95% CI -11 to 17; risk ratio [RR] 0.94 [95% CI 0.70 to 1.27]). The two groups did not significantly differ for quality of life, length of hospital stay, or the primary outcome in the prespecified subgroups of age, contralateral carotid occlusion, and baseline surgical risk. INTERPRETATION: We have not shown a definite difference in outcomes between general and local anaesthesia for carotid surgery. The anaesthetist and surgeon, in consultation with the patient, should decide which anaesthetic technique to use on an individual basis. FUNDING: The Health Foundation (UK) and European Society of Vascular Surgery.
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- 2008
21. AB0 Incompatible Liver Transplantation for Fulminant Liver Failure - The Czech Experience.
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Fronek, J., primary, Janousek, L., additional, Oliverius, M., additional, Kucera, M., additional, Kieslichova, E., additional, Viklicky, O., additional, and Trunecka, P., additional
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- 2014
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22. Incidental Hepatocellular Carcinoma: Risk Factors and Long-Term Outcome After Liver Transplantation
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Senkerikova, R., primary, Frankova, S., additional, Sperl, J., additional, Oliverius, M., additional, Kieslichova, E., additional, Filipova, H., additional, Kautznerova, D., additional, Honsova, E., additional, Trunecka, P., additional, and Spicak, J., additional
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- 2014
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23. Urgent Liver Transplantation for Chemotherapy-Induced HBV Reactivation: A Suitable Option in Patients Recently Treated for Malignant Iymphoma
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Sperl, J., primary, Frankova, S., additional, Kieslichova, E., additional, Oliverius, M., additional, Janousek, L., additional, Honsova, E., additional, Trunecka, P., additional, and Spicak, J., additional
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- 2013
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24. The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture
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Kieslichova, E., primary, Rocen, M., additional, Merta, D., additional, Kudla, M., additional, Splichal, I., additional, Cap, J., additional, Viklicky, O., additional, and Gürlich, R., additional
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- 2013
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25. The Effect of Prometheus Device on Laboratory Markers of Inflammation and Tissue Regeneration in Acute Liver Failure Management
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Rocen, M., primary, Kieslichova, E., additional, Merta, D., additional, Uchytilova, E., additional, Pavlova, Y., additional, Cap, J., additional, and Trunecka, P., additional
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- 2010
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26. The Laryngeal Mask Airway (LMA) as an alternative to airway management in mentally retarded patients during dental procedures
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Michalek, P, primary, Scigel, V, additional, Kieslichova, E, additional, and Rocen, M, additional
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- 2004
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27. Procalcitonin serum levels in patients after liver, pancreas and simultaneous kidney-pancreas transplantations
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Zazula, R, Prucha, M, Spaleny, A, and Kieslichova, E
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Poster Presentation - Published
- 2006
28. Hemodynamic parameters in a surgical devascularization model of fulminant hepatic failure in the minipig
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Kieslichova, E., Ryska, M., Pantoflicek, T., Ryska, O., Zazula Roman, and Skibova, J.
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Disease Models, Animal ,Ventricular Dysfunction, Left ,Hepatic Artery ,Heart Rate ,Reference Values ,Swine ,Physiology ,Animals ,Swine, Miniature ,Blood Pressure ,General Medicine ,Cardiac Output ,Liver Failure, Acute - Abstract
Animal models of fulminant hepatic failure (FHF) are important for studying the pathophysiology of this process and for evaluation of the efficacy of artificial and bioartificial liver support systems. In experiments, hemodynamic parameters were monitored in a group of minipigs with FHF induced by surgical devascularization, and compared with those in a control group. During the experiment, animals were analgosedated and were on mechanical lung ventilation. Crystalloid and colloidal solutions were administered and norepinephrine in continuous infusion was applied if mean arterial pressure (MAP) decreased below 60 mm Hg despite adequate intravascular volumes. An increase in heart rate, and decreases in MAP and systemic vascular resistance, compared with the baseline, occurred in the FHF group from 6 h after surgery. A comparison of FHF and control groups revealed no significant differences in systemic vascular resistance and MAP until after 12 h after surgery (systemic vascular resistance index: 953 FHF vs. 1658 controls; p < 0.05; MAP: 58.1 FHF vs. 76 controls; p < 0.05). No significant differences in CI were seen between the FHF group and controls. FHF animals survived for about 13 h after surgery, i.e. a period, which we consider long enough to test a support device. The parameters are believed to be quite adequate, as we were able to maintain satisfactory hemodynamic stability in all experimental animals with induced acute hepatic failure.
29. Long-term follow-up of the first 500 liver transplant recipients transplanted at the Institute for Clinical and Experimental Medicine in Prague | Výsledky dlouhodobého sledování prvních 500 pacientů po transplantaci jater provedených v Institutu klinické a experimentální medicíny v Praze
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Trunečka, P., Adamec, M., Špičák, J., Honsová, E., Kieslichova, E., Lánská, V., Peregrin, J., Milos Kucera, Janoušek, L., Oliverius, M., Drastich, P., Ročeň, M., Danč, R., Gottfriedová, H., Fraňková, S., Šperl, J., Pokorná, E., Vítko, Š, and Malý, J.
30. Collaborators in Acknowledgments in: Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective (vol 152, pg 321, 2017)
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Tomas, E., Bibonge, E. Amisi, Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kuebler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, G. Valcoreanu, Adriana, S., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Lee, K., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Shimomura, Y., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. Nik, Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. Nabil, Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, O. Moradi, Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J., Herridge, M., Fernandez, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R., Jimenez, E., Ryan, A., Prince, D., Edington, J., Haren, F., Bersten, A., Richards, B., Kilminster, M., Sturgess, D., Ziegenfuss, M., O Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, M. D. Agostino, Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Madeira Campos Melo, L., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. Souza, Costa Filho, R., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Colozza Mecatti, G., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, L. Castro, Duque, G. Libreros, Diaz-Guio, D., Benitez, F., Urrego, A. Guerra, Buitrago, R., Ortiz, G., Villalba Gaviria, M., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. Chung, Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. Martinez, Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. Rodriguez, Arrazola, F., Juan, L., Francisco, L. Juan, Namendys-Silva, S. A., Hernandez, M., Rodriguez Cadena, D., Lopez Islas, I., Ballesteros Zarzavilla, C., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Quispe, Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, S. Mareque, Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, D., Lahkar, B., Mandal, A., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Gurav, K. Zirpe, Patel, M., Bhavsar, A., Samaddar, D., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Philippe, G., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Vincent, J. L., Waele, J., Rimachi, R., Gusu, D., Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Herbert, S., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Leone, M., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Bernard, F., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, L., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Jaschinski, U., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Sakr, Y., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. Giannakou, Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Hoven, B., Reidinga, A., Kuiper, M., Pickkers, P., Kluge, G., Den Boer, S., Kesecioglu, J., Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Vintem Oliveira, A., Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. Kerin, Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Perez Valenzuela, J., Marina, L., Vidal-Cortes, P., Posada, P., Martin-Loeches, A. Ignacio, Munoz Guillen, N., Palomar, M., Sole-Violan, J., Torres, A., Gallego, M. Gonzalez, Aguilar, G., Allue, R. Montoiro, Argueso, M., Parejo, M., Palomo Navarro, M., Jose, A., Nin, N., Alvarez Lerma, F., Martinez, O., Lozano, E. Tenza, Arenal Lopez, S., Perez Granda, M., Moreno, S., Llubia, C., La Fuente Martos, C., Gonzalez-Arenas, P., Llamas Fernandez, N., Rueda, B. Gil, Pons, I. Estruch, Cruza, N., Maroto, F., Angel Estella, Ferrer, A., Fraile, L. Iglesias, Brigida, Q., Quintano, A., Tebar, M., Frutos-Vivar, F., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. Garcia, Yus, S., Maseda, E., Berezo, J., Tejero Pedregosa, A., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Mathew, S., Downes, R., Groba, C. Barrera, Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Williams, K., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., and Brealey, D.
31. Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units
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Vogelaers, Dirk, Blot, Stijn, Van den Berge, Andries, Montravers, Philippe, Francois, Guy, Labeau, Sonia, Blot, Koen, Deschepper, Mieke, Antonelli, Massimo, Lipman, Jeffrey, Lamrous, Amin, Pereyra, Cecilia, Lipovestky, Fernando, Koulenti, Despoina, De Waele, Jan, Rezende-Neto, Joao, Cardenas, Yenny, Vymazal, Tomas, Fjeldsoee-Nielsen, Hans, Kott, Matthias, Kostoula, Arvaniti, Javeri, Yash, Girardis, Massimo, Einav, Sharon, de Lange, Dylan, Makikado, Luis Daniel Umezawa, Mikstacki, Adam, Paiva, José-Artur, Tomescu, Dana, Gritsan, Alexey, Jovanovic, Bojan, Venkatesan, Kumaresh, Mirkovic, Tomislav, Maseda, Emilio, Dikmen, Yalim, Creagh-Brown, Benedict, Emmerich, Monica, Canale, Mariana, Dietz, Lorena Silvina, Ilutovich, Santiago, Miñope, John Thomas Sanchez, Silva, Ramona Baldomera, Montenegro, Martin Alexis, Martin, Patricio, Saul, Pablo, Chediack, Viviana, Sutton, Giselle, Couce, Rocio, Balasini, Carina, Gonzalez, Susana, Lascar, Florencia Maria, Descotte, Emiliano Jorge, Gumiela, Natalia Soledad, Pino, Carina Alejandra, Cesio, Cristian, Valgolio, Emanuel, Cunto, Eleonora, Dominguez, Cecilia, Nelson, Nydia Funes, Abegao, Esteban Martin, Pozo, Norberto Christian, Bianchi, Luciana, Correger, Enrique, Pastorino, Maria Laura, Miyazaki, Erica Aurora, Grubissich, Nicolas, Garcia, Mariel, Bonetto, Natalia, Quevedo, Noelia Elizabeth, Gomez, Cristina Delia, Queti, Felipe, Estevarena, Luis Gonzalez, Fernandez, Ruben, Santolaya, Ignacio, Grangeat, Sergio Hugo, Doglia, Juan, Zakalik, Graciela, Pellegrini, Carlos, Lloria, Maria Monserrat, Chacon, Mercedes Esteban, Fumale, Mariela, Leguizamon, Mariela, Hidalgo, Irene Beatriz, Tiranti, Roberto Julian, Capponi, Paola, Tita, Agustin, Cardonnet, Luis, Bettini, Lisandro, Ramos, Agñel, Lovesio, Luciano, Miranda, Edith Miriam, Farfan, Angelica Beatriz, Tolosa, Carina, Segura, Lise, Bellocchio, Adelina, Alvarez, Brian, Manzur, Adriana, Lujan, Rodolfo, Fernandez, Natalia, Scarone, Nahuel, Zazu, Alan, Groh, Carina, Fletcher, Jason, Smith, Julie, Azad, Raman, Chavan, Nitin, Wong, Helen, Kol, Mark, Campbell, Lewis, Starr, Therese, Roberts, Brigit, Wibrow, Bradley, Warhurst, Timothy, Chinthamuneedi, Meher, Ferney, Bernal Buitrago, Simon, Marc, De Backer, Daniel, Wittebole, Xavier, De Bels, David, Collin, Vincent, Dams, Karolien, Jorens, Philippe, Dubois, Jasperina, Gunst, Jan, Haentjens, Lionel, De Schryver, Nicolas, Dugernier, Thierry, Rizoli, Sandro, Santillan, Paul, Han, Yi, Biskup, Ewelina, Qu, Changjing, Li, Xinyu, Yu, Tao, Weihua, Lu, Molano-Franco, Daniel, Rojas, José, Oviedo, Juan Mauricio Pardo, Pinilla, Dario, Celis, Edgar, Arias, Mario, Vukovic, Anita, Vudrag, Maja, Belavic, Matija, Zunic, Josip, Kuharic, Janja, Kricka, Irena Bozanic, Filipovic-Grcic, Ina, Tomasevic, Boris, Obraz, Melanija, Bodulica, Bruna, Dohnal, Martin, Malaska, Jan, Kratochvil, Milan, Satinsky, Igor, Schwarz, Peter, Kos, Zdenek, Blahut, Ladislav, Maca, Jan, Protus, Marek, Kieslichová, Eva, Nielsen, Louise Gramstrup, Krogh, Birgitte Marianne, Rivadeneira, Francisco, Morales, Freddy, Mora, José, Orozco, Alexandra Saraguro, MorochoTutillo, Diego Rolando, Vargas, Nelson Remache, Yepez, Estuardo Salgado, Villamagua, Boris, Alsisi, Adel, Fahmy, Abdelraouf, Dupont, Hervé, Lasocki, Sigismond, Paugam-Burtz, Catherine, Foucrier, Arnaud, Nica, Alexandru, Barjon, Geneviève, Mallat, Jihad, Marcotte, Guillaume, Leone, Marc, Duclos, Gary, Burtin, Philippe, Atchade, Enora, Mahjoub, Yazine, Misset, Benoît, Timsit, Jean-François, Dupuis, Claire, Veber, Benoît, Debarre, Matthieu, Collange, Oliver, Pottecher, Julien, Hecketsweiler, Stephane, Fromentin, Mélanie, Tesnière, Antoine, Koch, Christian, Sander, Michael, Eckmann, Christian, Elke, Gunnar, Wrigge, Hermann, Simon, Philipp, Chalkiadaki, Anthoula, Tzanidakis, Charalampos, Pneumatikos, Ioannis, Sertaridou, Eleni, Mastora, Zafiria, Pantazopoulos, Ioannis, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Floros, John, Kolonia, Virginia, Dimopoulos, George, Diakaki, Chryssa, Rallis, Michael, Paridou, Alexandra, Kalogeromitros, Alexandros, Romanou, Vasiliki, Nikolaou, Charikleia, Kounougeri, Katerina, Tsigou, Evdoxia, Psallida, Vasiliki, Karampela, Niki, Mandragos, Konstantinos, Kontoudaki, Eftychia, Pentheroudaki, Alexandra, Farazi-Chongouki, Christos, Karakosta, Agathi, Chouris, Isaac, Radu, Vasiliki, Malliotakis, Polychronis, Kokkini, Sofia, Charalambous, Eliana, Kyritsi, Aikaterini, Koulouras, Vasilios, Papathanakos, Georgios, Nagky, Eva, Lampiri, Clairi, Tsimpoukas, Fotios, Sarakatsanos, Ioannis, Georgakopoulos, Panagiotis, Ravani, Ifigeneia, Prekates, Athanasios, Sakellaridis, Konstantinos, Christopoulos, Christos, Vrettou, Efstratia, Stokkos, Konstantinos, Pentari, Anastasia, Arvaniti, Kostoula, Marmanidou, Kyriaki, Kydona, Christina, Tsoumaropoulos, Georgios, Bitzani, Militisa, Kontou, Paschalina, Voudouris, Antonios, Elli-Nikki, [missing], Flioni, [missing], Antypa, Elli, Chasou, Eleftheria, Anisoglou, Souzana, Papageorgiou, Eirini, Paraforou, Theoniki, Tsioka, Agoritsa, Karathanou, Antigoni, Vakalos, Aristeidis, Shah, Bhagyesh, Thakkar, Chirag, Jain, Nikhilesh, Gurjar, Mohan, Baronia, Arvind, Sathe, Prachee, Kulkarni, Shilpa, Paul, Cherish, Paul, John, Masjedi, Mansoor, Nikandish, Reza, Zand, Farid, Sabetian, Golnar, Mahmoodpoor, Ata, Hashemian, Seyed Mohammadreza, Bala, Miklosh, Flocco, Romeo, Torrente, Sergio, Pota, Vincenzo, Spadaro, Savino, Volta, Carlo, Serafini, Giulia, Boraso, Sabrina, Tiberio, Ivo, Cortegiani, Andrea, Misseri, Giovanni, Barbagallo, Maria, Nicolotti, Davide, Forfori, Francesco, Corradi, Francesco, De Pascale, Gennaro, Pelagalli, Lorella, Brazzi, Luca, Vittone, Ferdinando Giorgio, Russo, Alessandro, Simion, Davide, Cotoia, Antonella, Cinnella, Gilda, Toppin, Patrick, Johnson-Jackson, Roxanne, Hayashi, Yoshiro, Yamamoto, Ryohei, Yasuda, Hideto, Kishihara, Yuki, Shiotsuka, Junji, Sanchez-Hurtado, Luis Alejandro, Tejeda-Huezo, Brigitte, Gorordo, Luis, Ñamendys-Silva, Silvio A., Garcia-Guillen, Francisco J., Martinez, Manuel, Romero-Meja, Erick, Colorado-Dominguez, Ever, van den Oever, Huub, Kalff, Karel Martijn, Vermeijden, Wytze, Cornet, Alexander Daniel, Beck, Oliver, Cimic, Nedim, Dormans, Tom, Bormans, Laura, Bakker, Jan, Van Duijn, Ditty, Bosman, Gerrit, Vos, Piet, Haas, Lenneke, Henein, Akram, Miranda, Ariel M., Malca, Gonzalo Ernesto Gianella, Arroyo-Sanchez, Abel, Misiewska-Kaczur, Agnieszka, Akinyi, Frisch, Czuczwar, Miroslaw, Luczak, Karolina, Sulkowski, Wiktor, Tamowicz, Barbara, Swit, Beata, Baranowski, Bronisław, Smuszkiewicz, Piotr, Trojanowska, Iwona, Rzymski, Stanislaw, Sawinski, Mariusz, Trosiak, Marta, Mikaszewska-Sokolewicz, Malgorzata, Alves, Ricardo, Leal, Dina, Krystopchuk, Andriy, Mendonca, Pedro Muguel Hilario, Pereira, Rui Antunes, de Carvalho, Maria Raquel Lopes Marques, Candeias, Carlos, Molinos, Elena, Ferreira, Amélia, Castro, Guiomar, Pereira, José-Manuel, Santos, Lurdes, Ferreira, Alcina, Pascoalinho, Dulce, Ribeiro, Rosa, Domingos, Guilherme, Gomes, Pedro, Nora, David, Costa, Rui Pedro, Santos, Anabela, Alsheikhly, Ahmed Subhy, Popescu, Mihai, Grigoras, Ioana, Patrascanu, Emilia, Zabolotskikh, Igor, Musaeva, Tatiana, Gaigolnik, Denis, Kulabukhov, Vladimir, Belskiy, Vladislav, Zubareva, Nadezhda, Tribulev, Maxim, Abdelsalam, Ahmed, Aldarsani, Ayman, Al-Khalid, Muhammad, Almekhlafi, Ghaleb, Mandourah, Yasser, Doklestic, Krstina, Velickovic, Jelena, Velickovic, Dejan, Jankovic, Radmilo, Skoric-Jokic, Svetlana, Radovanovic, Dragana, Richards, Guy, Alli, Ahmad, Del Carmen Cordoba Nielfa, Maria, Iniesta, Rafael Sánchez, Martínez, Adela Benítez-Cano, Bernedo, Carlos Garcia, Gil, Santiago Alberto Picos, Nuvials, Xavier, Rello, Jordi, Garcia, Joseba Gonzalez, Peña, Jose Manuel Garcia, Jimenez, Roberto, Herrera, Luis, Barrachina, Laura Galarza, Monzon, Ignacio Catalan, Redondo, Francisco Javier, Villazala, Ruben, Zapata, Diego Fernando Matallana, Lopez, Isabel Maria Villa, Moreno-Gonzalez, Gabriel, Lopez-Delgado, Juan Carlos, Marin, Jorge Solera, Sanchez-Zamora, Purificacion, Vidal, Montserrat Vallverdú, González, Jesús Flores, Salinas, Irene, Hermosa, Cecilia, Martinez-Sagasti, Fernando, Domingo-Marín, Sara, Victorino, Johanna Abril, Garcia-Alvarez, Raquel, Calleja, Pablo López-Arcas, de la Torre-Prados, Maria-Victoria, Vidal-Cortes, Pablo, Del Río-Carbajo, Lorena, Izura, Javier, Minguez, Victoria, Alvarez, Josep Trenado, Prous, Anna Parera, Paz, Daniel, Roche-Campo, Ferran, Aguilar, Gerardo, Belda, Javier, Rico-Feijoo, Jesus, Aldecoa, Cesat, Zalba-Etayo, Begoña, Lang, Martin, Dullenkopf, Alexander, Trongtrakul, Konlawij, Chtsomkasem, Anusang, Akbaş, Türkay, Unal, Mustafa Necmettin, Ozcelik, Menekse, Gumus, Ayca, Ramazanoglu, Atilla, Memis, Dilek, Mehmet, Inal, Urkmez, Seval, Ozgultekin, Asu, Demirkiran, Oktay, Aslan, Nesrin Ahu, Kizilaslan, Deniz, Kahveci, Ferda, Ünlü, Nurdan, Ozkan, Zeynep, Kaye, Callum, Jansen, Jan, O’Neill, Orla, Nutt, Christopher, Jha, Rajeev, Hooker, Nicolas, Grecu, Irina, Petridou, Christina, Shyamsundar, Murali, McNamee, Lia, Trinder, John, Hagan, Samantha, Kelly, Catriona, Silversides, Jonathon, Groba, Casiano Barrera, Boyd, Owen, Bhowmick, Kaushik, Humphreys, Sally, Summers, Charlotte, Polgarova, Petra, Margarson, Michael, Dickens, Justin, Pearson, Suzanne, Chinery, Elaine, Hemmings, Noel, O’Kane, Sinead, Austin, Pauline, Cole, Stephen, Plowright, Catherine, Box, Roberta, Wright, Christopher, Young, Lorna, Creagh-Brown, Ben, Montague, Laura, Parker, Robert, Morton, Ben, Ostermann, Marlies, Bilinska, Julia, Rose, Bernd Oliver, Reece-Anthony, Rosie, Ryan, Christine, Hamilton, Mark, Hopkins, Philip, Wendon, Julia, Brescia, Giovanni, Ijaz, Nazia, Wood, James, George, Michelle, Toth-Tarsoly, Piroska, Yates, Bryan, Armstrong, Maureen, Scott, Carmen, Boyd, Christine, Szakmany, Tamas, Rees, David, Pulak, Paul, Coggon, Mandy, Saha, Bhaskar, Kent, Linda, Gibson, Bethan, Camsooksai, Julie, Reschreiter, Henrik, Morgan, Pat, Sangaralingham, Sivatharshini, Lowe, Alastair, Vondras, Petr, Jamadarkhana, Sunil, Cruz, Carina, Bhandary, Rakesh, Hersey, Peter, Furneval, Julie, Innes, Richard, Doble, Patricia, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiaobei, Dalton, Julian, Hegazy, Mohammed, Awad, Yasser, Naylor, Douglas, Naylor, Amanda, Lee, Sarah, Brevard, Sidney, Davis, Noelle, for the Abdominal Sepsis Study (‘AbSeS’) Group on behalf of the Trials Group of the European Society of Intensive Care Medicine, [missing], Vogelaers D., Blot S., Van den Berge A., Montravers P., Francois G., Labeau S., Blot K., Deschepper M., Antonelli M., Lipman J., Lamrous A., Pereyra C., Lipovestky F., Koulenti D., De Waele J., Rezende-Neto J., Cardenas Y., Vymazal T., Fjeldsoee-Nielsen H., Kott M., Kostoula A., Javeri Y., Girardis M., Einav S., de Lange D., Makikado L.D.U., Mikstacki A., Paiva J.-A., Tomescu D., Gritsan A., Jovanovic B., Venkatesan K., Mirkovic T., Maseda E., Dikmen Y., Creagh-Brown B., Emmerich M., Canale M., Dietz L.S., Ilutovich S., Minope J.T.S., Silva R.B., Montenegro M.A., Martin P., Saul P., Chediack V., Sutton G., Couce R., Balasini C., Gonzalez S., Lascar F.M., Descotte E.J., Gumiela N.S., Pino C.A., Cesio C., Valgolio E., Cunto E., Dominguez C., Nelson N.F., Abegao E.M., Pozo N.C., Bianchi L., Correger E., Pastorino M.L., Miyazaki E.A., Grubissich N., Garcia M., Bonetto N., Quevedo N.E., Gomez C.D., Queti F., Estevarena L.G., Fernandez R., Santolaya I., Grangeat S.H., Doglia J., Zakalik G., Pellegrini C., Lloria M.M., Chacon M.E., Fumale M., Leguizamon M., Hidalgo I.B., Tiranti R.J., Capponi P., Tita A., Cardonnet L., Bettini L., Ramos A., Lovesio L., Miranda E.M., Farfan A.B., Tolosa C., Segura L., Bellocchio A., Alvarez B., Manzur A., Lujan R., Fernandez N., Scarone N., Zazu A., Groh C., Fletcher J., Smith J., Azad R., Chavan N., Wong H., Kol M., Campbell L., Starr T., Roberts B., Wibrow B., Warhurst T., Chinthamuneedi M., Ferney B.B., Simon M., De Backer D., Wittebole X., De Bels D., Collin V., Dams K., Jorens P., Dubois J., Gunst J., Haentjens L., De Schryver N., Dugernier T., Rizoli S., Santillan P., Han Y., Biskup E., Qu C., Li X., Yu T., Weihua L., Molano-Franco D., Rojas J., Oviedo J.M.P., Pinilla D., Celis E., Arias M., Vukovic A., Vudrag M., Belavic M., Zunic J., Kuharic J., Kricka I.B., Filipovic-Grcic I., Tomasevic B., Obraz M., Bodulica B., Dohnal M., Malaska J., Kratochvil M., Satinsky I., Schwarz P., Kos Z., Blahut L., Maca J., Protus M., Kieslichova E., Nielsen L.G., Krogh B.M., Rivadeneira F., Morales F., Mora J., Orozco A.S., MorochoTutillo D.R., Vargas N.R., Yepez E.S., Villamagua B., Alsisi A., Fahmy A., Dupont H., Lasocki S., Paugam-Burtz C., Foucrier A., Nica A., Barjon G., Mallat J., Marcotte G., Leone M., Duclos G., Burtin P., Atchade E., Mahjoub Y., Misset B., Timsit J.-F., Dupuis C., Veber B., Debarre M., Collange O., Pottecher J., Hecketsweiler S., Fromentin M., Tesniere A., Koch C., Sander M., Eckmann C., Elke G., Wrigge H., Simon P., Chalkiadaki A., Tzanidakis C., Pneumatikos I., Sertaridou E., Mastora Z., Pantazopoulos I., Papanikolaou M., Papavasilopoulou T., Floros J., Kolonia V., Dimopoulos G., Diakaki C., Rallis M., Paridou A., Kalogeromitros A., Romanou V., Nikolaou C., Kounougeri K., Tsigou E., Psallida V., Karampela N., Mandragos K., Kontoudaki E., Pentheroudaki A., Farazi-Chongouki C., Karakosta A., Chouris I., Radu V., Malliotakis P., Kokkini S., Charalambous E., Kyritsi A., Koulouras V., Papathanakos G., Nagky E., Lampiri C., Tsimpoukas F., Sarakatsanos I., Georgakopoulos P., Ravani I., Prekates A., Sakellaridis K., Christopoulos C., Vrettou E., Stokkos K., Pentari A., Arvaniti K., Marmanidou K., Kydona C., Tsoumaropoulos G., Bitzani M., Kontou P., Voudouris A., Elli-Nikki, Flioni, Antypa E., Chasou E., Anisoglou S., Papageorgiou E., Paraforou T., Tsioka A., Karathanou A., Vakalos A., Shah B., Thakkar C., Jain N., Gurjar M., Baronia A., Sathe P., Kulkarni S., Paul C., Paul J., Masjedi M., Nikandish R., Zand F., Sabetian G., Mahmoodpoor A., Hashemian S.M., Bala M., Flocco R., Torrente S., Pota V., Spadaro S., Volta C., Serafini G., Boraso S., Tiberio I., Cortegiani A., Misseri G., Barbagallo M., Nicolotti D., Forfori F., Corradi F., De Pascale G., Pelagalli L., Brazzi L., Vittone F.G., Russo A., Simion D., Cotoia A., Cinnella G., Toppin P., Johnson-Jackson R., Hayashi Y., Yamamoto R., Yasuda H., Kishihara Y., Shiotsuka J., Sanchez-Hurtado L.A., Tejeda-Huezo B., Gorordo L., Namendys-Silva S.A., Garcia-Guillen F.J., Martinez M., Romero-Meja E., Colorado-Dominguez E., van den Oever H., Kalff K.M., Vermeijden W., Cornet A.D., Beck O., Cimic N., Dormans T., Bormans L., Bakker J., Van Duijn D., Bosman G., Vos P., Haas L., Henein A., Miranda A.M., Malca G.E.G., Arroyo-Sanchez A., Misiewska-Kaczur A., Akinyi F., Czuczwar M., Luczak K., Sulkowski W., Tamowicz B., Swit B., Baranowski B., Smuszkiewicz P., Trojanowska I., Rzymski S., Sawinski M., Trosiak M., Mikaszewska-Sokolewicz M., Alves R., Leal D., Krystopchuk A., Mendonca P.M.H., Pereira R.A., de Carvalho M.R.L.M., Candeias C., Molinos E., Ferreira A., Castro G., Pereira J.-M., Santos L., Pascoalinho D., Ribeiro R., Domingos G., Gomes P., Nora D., Costa R.P., Santos A., Alsheikhly A.S., Popescu M., Grigoras I., Patrascanu E., Zabolotskikh I., Musaeva T., Gaigolnik D., Kulabukhov V., Belskiy V., Zubareva N., Tribulev M., Abdelsalam A., Aldarsani A., Al-Khalid M., Almekhlafi G., Mandourah Y., Doklestic K., Velickovic J., Velickovic D., Jankovic R., Skoric-Jokic S., Radovanovic D., Richards G., Alli A., Del Carmen Cordoba Nielfa M., Iniesta R.S., Martinez A.B.-C., Bernedo C.G., Gil S.A.P., Nuvials X., Rello J., Garcia J.G., Pena J.M.G., Jimenez R., Herrera L., Barrachina L.G., Monzon I.C., Redondo F.J., Villazala R., Zapata D.F.M., Lopez I.M.V., Moreno-Gonzalez G., Lopez-Delgado J.C., Marin J.S., Sanchez-Zamora P., Vidal M.V., Gonzalez J.F., Salinas I., Hermosa C., Martinez-Sagasti F., Domingo-Marin S., Victorino J.A., Garcia-Alvarez R., Calleja P.L.-A., de la Torre-Prados M.-V., Vidal-Cortes P., Del Rio-Carbajo L., Izura J., Minguez V., Alvarez J.T., Prous A.P., Paz D., Roche-Campo F., Aguilar G., Belda J., Rico-Feijoo J., Aldecoa C., Zalba-Etayo B., Lang M., Dullenkopf A., Trongtrakul K., Chtsomkasem A., Akbas T., Unal M.N., Ozcelik M., Gumus A., Ramazanoglu A., Memis D., Mehmet I., Urkmez S., Ozgultekin A., Demirkiran O., Aslan N.A., Kizilaslan D., Kahveci F., Unlu N., Ozkan Z., Kaye C., Jansen J., O'Neill O., Nutt C., Jha R., Hooker N., Grecu I., Petridou C., Shyamsundar M., McNamee L., Trinder J., Hagan S., Kelly C., Silversides J., Groba C.B., Boyd O., Bhowmick K., Humphreys S., Summers C., Polgarova P., Margarson M., Dickens J., Pearson S., Chinery E., Hemmings N., O'Kane S., Austin P., Cole S., Plowright C., Box R., Wright C., Young L., Montague L., Parker R., Morton B., Ostermann M., Bilinska J., Rose B.O., Reece-Anthony R., Ryan C., Hamilton M., Hopkins P., Wendon J., Brescia G., Ijaz N., Wood J., George M., Toth-Tarsoly P., Yates B., Armstrong M., Scott C., Boyd C., Szakmany T., Rees D., Pulak P., Coggon M., Saha B., Kent L., Gibson B., Camsooksai J., Reschreiter H., Morgan P., Sangaralingham S., Lowe A., Vondras P., Jamadarkhana S., Cruz C., Bhandary R., Hersey P., Furneval J., Innes R., Doble P., Attwood B., Parsons P., Page V., Zhao X., Dalton J., Hegazy M., Awad Y., Naylor D., Naylor A., Lee S., Brevard S., Davis N., UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Vogelaers, D., Blot, S., Van den Berge, A., Montravers, P., Francois, G., Labeau, S., Blot, K., Deschepper, M., Antonelli, M., Lipman, J., Lamrous, A., Pereyra, C., Lipovestky, F., Koulenti, D., De Waele, J., Rezende-Neto, J., Cardenas, Y., Vymazal, T., Fjeldsoee-Nielsen, H., Kott, M., Kostoula, A., Javeri, Y., Girardis, M., Einav, S., de Lange, D., Makikado, L. D. U., Mikstacki, A., Paiva, J. -A., Tomescu, D., Gritsan, A., Jovanovic, B., Venkatesan, K., Mirkovic, T., Maseda, E., Dikmen, Y., Creagh-Brown, B., Emmerich, M., Canale, M., Dietz, L. S., Ilutovich, S., Minope, J. T. S., Silva, R. B., Montenegro, M. A., Martin, P., Saul, P., Chediack, V., Sutton, G., Couce, R., Balasini, C., Gonzalez, S., Lascar, F. M., Descotte, E. J., Gumiela, N. S., Pino, C. A., Cesio, C., Valgolio, E., Cunto, E., Dominguez, C., Nelson, N. F., Abegao, E. M., Pozo, N. C., Bianchi, L., Correger, E., Pastorino, M. L., Miyazaki, E. A., Grubissich, N., Garcia, M., Bonetto, N., Quevedo, N. E., Gomez, C. D., Queti, F., Estevarena, L. G., Fernandez, R., Santolaya, I., Grangeat, S. H., Doglia, J., Zakalik, G., Pellegrini, C., Lloria, M. M., Chacon, M. E., Fumale, M., Leguizamon, M., Hidalgo, I. B., Tiranti, R. J., Capponi, P., Tita, A., Cardonnet, L., Bettini, L., Ramos, A., Lovesio, L., Miranda, E. M., Farfan, A. B., Tolosa, C., Segura, L., Bellocchio, A., Alvarez, B., Manzur, A., Lujan, R., Fernandez, N., Scarone, N., Zazu, A., Groh, C., Fletcher, J., Smith, J., Azad, R., Chavan, N., Wong, H., Kol, M., Campbell, L., Starr, T., Roberts, B., Wibrow, B., Warhurst, T., Chinthamuneedi, M., Ferney, B. B., Simon, M., De Backer, D., Wittebole, X., De Bels, D., Collin, V., Dams, K., Jorens, P., Dubois, J., Gunst, J., Haentjens, L., De Schryver, N., Dugernier, T., Rizoli, S., Santillan, P., Han, Y., Biskup, E., Qu, C., Li, X., Yu, T., Weihua, L., Molano-Franco, D., Rojas, J., Oviedo, J. M. P., Pinilla, D., Celis, E., Arias, M., Vukovic, A., Vudrag, M., Belavic, M., Zunic, J., Kuharic, J., Kricka, I. B., Filipovic-Grcic, I., Tomasevic, B., Obraz, M., Bodulica, B., Dohnal, M., Malaska, J., Kratochvil, M., Satinsky, I., Schwarz, P., Kos, Z., Blahut, L., Maca, J., Protus, M., Kieslichova, E., Nielsen, L. G., Krogh, B. M., Rivadeneira, F., Morales, F., Mora, J., Orozco, A. S., Morochotutillo, D. R., Vargas, N. R., Yepez, E. S., Villamagua, B., Alsisi, A., Fahmy, A., Dupont, H., Lasocki, S., Paugam-Burtz, C., Foucrier, A., Nica, A., Barjon, G., Mallat, J., Marcotte, G., Leone, M., Duclos, G., Burtin, P., Atchade, E., Mahjoub, Y., Misset, B., Timsit, J. -F., Dupuis, C., Veber, B., Debarre, M., Collange, O., Pottecher, J., Hecketsweiler, S., Fromentin, M., Tesniere, A., Koch, C., Sander, M., Eckmann, C., Elke, G., Wrigge, H., Simon, P., Chalkiadaki, A., Tzanidakis, C., Pneumatikos, I., Sertaridou, E., Mastora, Z., Pantazopoulos, I., Papanikolaou, M., Papavasilopoulou, T., Floros, J., Kolonia, V., Dimopoulos, G., Diakaki, C., Rallis, M., Paridou, A., Kalogeromitros, A., Romanou, V., Nikolaou, C., Kounougeri, K., Tsigou, E., Psallida, V., Karampela, N., Mandragos, K., Kontoudaki, E., Pentheroudaki, A., Farazi-Chongouki, C., Karakosta, A., Chouris, I., Radu, V., Malliotakis, P., Kokkini, S., Charalambous, E., Kyritsi, A., Koulouras, V., Papathanakos, G., Nagky, E., Lampiri, C., Tsimpoukas, F., Sarakatsanos, I., Georgakopoulos, P., Ravani, I., Prekates, A., Sakellaridis, K., Christopoulos, C., Vrettou, E., Stokkos, K., Pentari, A., Arvaniti, K., Marmanidou, K., Kydona, C., Tsoumaropoulos, G., Bitzani, M., Kontou, P., Voudouris, A., Elli-Nikki, Flioni, Antypa, E., Chasou, E., Anisoglou, S., Papageorgiou, E., Paraforou, T., Tsioka, A., Karathanou, A., Vakalos, A., Shah, B., Thakkar, C., Jain, N., Gurjar, M., Baronia, A., Sathe, P., Kulkarni, S., Paul, C., Paul, J., Masjedi, M., Nikandish, R., Zand, F., Sabetian, G., Mahmoodpoor, A., Hashemian, S. M., Bala, M., Flocco, R., Torrente, S., Pota, V., Spadaro, S., Volta, C., Serafini, G., Boraso, S., Tiberio, I., Cortegiani, A., Misseri, G., Barbagallo, M., Nicolotti, D., Forfori, F., Corradi, F., De Pascale, G., Pelagalli, L., Brazzi, L., Vittone, F. G., Russo, A., Simion, D., Cotoia, A., Cinnella, G., Toppin, P., Johnson-Jackson, R., Hayashi, Y., Yamamoto, R., Yasuda, H., Kishihara, Y., Shiotsuka, J., Sanchez-Hurtado, L. A., Tejeda-Huezo, B., Gorordo, L., Namendys-Silva, S. A., Garcia-Guillen, F. J., Martinez, M., Romero-Meja, E., Colorado-Dominguez, E., van den Oever, H., Kalff, K. M., Vermeijden, W., Cornet, A. D., Beck, O., Cimic, N., Dormans, T., Bormans, L., Bakker, J., Van Duijn, D., Bosman, G., Vos, P., Haas, L., Henein, A., Miranda, A. M., Malca, G. E. G., Arroyo-Sanchez, A., Misiewska-Kaczur, A., Akinyi, F., Czuczwar, M., Luczak, K., Sulkowski, W., Tamowicz, B., Swit, B., Baranowski, B., Smuszkiewicz, P., Trojanowska, I., Rzymski, S., Sawinski, M., Trosiak, M., Mikaszewska-Sokolewicz, M., Alves, R., Leal, D., Krystopchuk, A., Mendonca, P. M. H., Pereira, R. A., de Carvalho, M. R. L. M., Candeias, C., Molinos, E., Ferreira, A., Castro, G., Pereira, J. -M., Santos, L., Pascoalinho, D., Ribeiro, R., Domingos, G., Gomes, P., Nora, D., Costa, R. P., Santos, A., Alsheikhly, A. S., Popescu, M., Grigoras, I., Patrascanu, E., Zabolotskikh, I., Musaeva, T., Gaigolnik, D., Kulabukhov, V., Belskiy, V., Zubareva, N., Tribulev, M., Abdelsalam, A., Aldarsani, A., Al-Khalid, M., Almekhlafi, G., Mandourah, Y., Doklestic, K., Velickovic, J., Velickovic, D., Jankovic, R., Skoric-Jokic, S., Radovanovic, D., Richards, G., Alli, A., Del Carmen Cordoba Nielfa, M., Iniesta, R. S., Martinez, A. B. -C., Bernedo, C. G., Gil, S. A. P., Nuvials, X., Rello, J., Garcia, J. G., Pena, J. M. G., Jimenez, R., Herrera, L., Barrachina, L. G., Monzon, I. C., Redondo, F. J., Villazala, R., Zapata, D. F. M., Lopez, I. M. V., Moreno-Gonzalez, G., Lopez-Delgado, J. C., Marin, J. S., Sanchez-Zamora, P., Vidal, M. V., Gonzalez, J. F., Salinas, I., Hermosa, C., Martinez-Sagasti, F., Domingo-Marin, S., Victorino, J. A., Garcia-Alvarez, R., Calleja, P. L. -A., de la Torre-Prados, M. -V., Vidal-Cortes, P., Del Rio-Carbajo, L., Izura, J., Minguez, V., Alvarez, J. T., Prous, A. P., Paz, D., Roche-Campo, F., Aguilar, G., Belda, J., Rico-Feijoo, J., Aldecoa, C., Zalba-Etayo, B., Lang, M., Dullenkopf, A., Trongtrakul, K., Chtsomkasem, A., Akbas, T., Unal, M. N., Ozcelik, M., Gumus, A., Ramazanoglu, A., Memis, D., Mehmet, I., Urkmez, S., Ozgultekin, A., Demirkiran, O., Aslan, N. A., Kizilaslan, D., Kahveci, F., Unlu, N., Ozkan, Z., Kaye, C., Jansen, J., O'Neill, O., Nutt, C., Jha, R., Hooker, N., Grecu, I., Petridou, C., Shyamsundar, M., Mcnamee, L., Trinder, J., Hagan, S., Kelly, C., Silversides, J., Groba, C. B., Boyd, O., Bhowmick, K., Humphreys, S., Summers, C., Polgarova, P., Margarson, M., Dickens, J., Pearson, S., Chinery, E., Hemmings, N., O'Kane, S., Austin, P., Cole, S., Plowright, C., Box, R., Wright, C., Young, L., Montague, L., Parker, R., Morton, B., Ostermann, M., Bilinska, J., Rose, B. O., Reece-Anthony, R., Ryan, C., Hamilton, M., Hopkins, P., Wendon, J., Brescia, G., Ijaz, N., Wood, J., George, M., Toth-Tarsoly, P., Yates, B., Armstrong, M., Scott, C., Boyd, C., Szakmany, T., Rees, D., Pulak, P., Coggon, M., Saha, B., Kent, L., Gibson, B., Camsooksai, J., Reschreiter, H., Morgan, P., Sangaralingham, S., Lowe, A., Vondras, P., Jamadarkhana, S., Cruz, C., Bhandary, R., Hersey, P., Furneval, J., Innes, R., Doble, P., Attwood, B., Parsons, P., Page, V., Zhao, X., Dalton, J., Hegazy, M., Awad, Y., Naylor, D., Naylor, A., Lee, S., Brevard, S., and Davis, N.
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Drug Resistance ,medicine.disease_cause ,Severity of Illness Index ,law.invention ,0302 clinical medicine ,ENTEROBACTERIACEAE ,law ,Drug Resistance, Multiple, Bacterial ,Medicine and Health Sciences ,Pharmacology (medical) ,Cross Infection ,biology ,Bacterial ,Antimicrobial ,Intensive care unit ,Anti-Bacterial Agents ,Community-Acquired Infections ,Europe ,Intensive Care Units ,Critical Illness ,Humans ,Intraabdominal Infections ,Microbial Sensitivity Tests ,Peritonitis ,Sepsis ,ESCHERICHIA-COLI ,030220 oncology & carcinogenesis ,KLEBSIELLA-PNEUMONIAE ,BLOOD-STREAM INFECTIONS ,PYELONEPHRITIS ,Multiple ,medicine.medical_specialty ,Enterococcus faecalis ,NO ,03 medical and health sciences ,Intra‑abdominal Infections ,Antibiotic resistance ,FOOD ,Intensive care ,Internal medicine ,medicine ,FLUOROQUINOLONE RESISTANCE ,Pseudomonas aeruginosa ,business.industry ,Septic shock ,MORTALITY ,biology.organism_classification ,medicine.disease ,RISK-FACTORS ,business ,030217 neurology & neurosurgery ,Enterococcus faecium - Abstract
Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. In this study, we report on resistance profiles of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis and Enterococcus faecium in distinct European geographic regions based on an observational cohort study on intra-abdominal infections in intensive care unit (ICU) patients. Resistance against aminopenicillins, fluoroquinolones, and third-generation cephalosporins in E. coli, K. pneumoniae and P. aeruginosa is problematic, as is carbapenem-resistance in the latter pathogen. For E. coli and K. pneumoniae, resistance is mainly an issue in Central Europe, Eastern and South-East Europe, and Southern Europe, while resistance in P. aeruginosa is additionally problematic in Western Europe. Vancomycin-resistance in E. faecalis is of lesser concern but requires vigilance in E. faecium in Central and Eastern and South-East Europe. In the subcohort of patients with secondary peritonitis presenting with either sepsis or septic shock, the appropriateness of empiric antimicrobial therapy was not associated with mortality. In contrast, failure of source control was strongly associated with mortality. The relevance of these new insights for future recommendations regarding empiric antimicrobial therapy in intra-abdominal infections is discussed.
- Published
- 2021
32. Lack of Impact of Hyperchloremia in Brain-Dead Organ Donors on the Onset of Kidney Allograft Function in the Recipients.
- Author
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Pokorna, E., Uchytilova, E., Protus, M., Merta, D., Kieslichova, E., and Kula, R.
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CHLORIDES in the body , *ORGAN donors , *BODY fluid disorders , *KIDNEY transplant patients , *HOMOGRAFTS , *GLOMERULAR filtration rate , *VASOCONSTRICTION , *DISEASES - Abstract
Background Hyperchloremia produces renal vasoconstriction and fall in glomerular filtration rate. In 90% of brain-dead organ donors, diabetes insipidus develops, characterized by inappropriate diuresis, hyperosmolality, and hyperchloremia. The aim of this study was to determine the relationship between the serum concentration of chlorides of the donor and the onset of the function of the kidney allograft in the recipient. Methods We retrospectively studied 213 donors and kidney allograft recipients. Serum creatinine concentrations and glomerular filtration rates on the 1st, 7th, and 30th days after transplantation of the recipients from hyperchloremic donors were compared with the recipients from normochloremic donors, as well as the incidences of acute tubular necrosis and delayed graft function. Results On the 1st day, serum creatinine concentrations of the recipients from hyperchloremic and normochloremic donors, respectively, were 448.2 ± 212.1 μmol/L and 502.2 ± 197.8 μmol/L ( P = .1), on the 7th day, 168.6 ± 102.6 μmol/L and 196.9 ± 120.6 μmol/L ( P = .13), and on the 30th day, 129.4 ± 43.3 μmol/L and 131.8 ± 43.6 μmol/L ( P = .73). The differences were statistically significant. The groups also did not differ significantly in glomerular filtration rates and incidences of acute tubular necrosis and delayed graft function. Conclusions In this study, no significant correlation between serum chloride concentrations of the organ donors and the onset of the function of kidney allografts in the recipients was found. [ABSTRACT FROM AUTHOR]
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- 2017
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33. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: 'AbSeS', a multinational observational cohort study and ESICM Trials Group Project
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Blot, S. aEmail Author, Antonelli M. b, c Arvaniti, K. d Blot, K. a Creagh-Brown, B. e f, de Lange, D. g, De Waele, J. h Deschepper, M. i Dikmen, Y. j Dimopoulos, G. k Eckmann, C. l Francois, G. m Girardis, M. n Koulenti, D. o p, Labeau S. a, q Lipman, J. r s, Lipovestky F. t, Maseda E. u, Montravers P. v, w Mikstacki, A. x y, Paiva, J. -A. z, Pereyra, C. aa, Rello, J. ab, Timsit, J. -F. ac, ad Vogelaers, D. ae, Lamrous A., Rezende-Neto J., Cardenas Y., Vymazal T., Fjeldsoee-Nielsen H., Kott M., Kostoula A., Javeri Y., Einav S., Makikado L. D. U., Tomescu D., Gritsan A., Jovanovic B., Venkatesan K., Mirkovic T., Creagh-Brown B., Emmerich M., Canale M., Dietz L. S., Ilutovich S., Miñope J. T. S., Silva R. B., Montenegro M. A., Martin P., Saul P., Chediack V., Sutton G., Couce R., Balasini C., Gonzalez S., Lascar F. M., Descotte E. J., Gumiela N. S., Pino C. A., Cesio C., Valgolio E., Cunto E., Dominguez C., Nelson N. F., Abegao E. M., Pozo N. C., Bianchi L., Correger E., Pastorino M. L., Miyazaki E. A., Grubissich N., Garcia M., Bonetto N., Quevedo N. E., Gomez C. D., Queti F., Estevarena L. G., Fernandez R., Santolaya I., Grangeat S. H., Doglia J., Zakalik G., Pellegrini C., Lloria M. M., Chacon M. E., Fumale M., Leguizamon M., Hidalgo I. B., Tiranti R. J., Capponi P., Tita A., Cardonnet L., Bettini L., Ramos A., Lovesio L., Miranda E. M., Farfan A. B., Tolosa C., Segura L., Bellocchio A., Alvarez B., Manzur A., Lujan R., Fernandez N., Scarone N., Zazu A., Groh C., Fletcher J., Smith J., Azad R., Chavan N., Wong H., Kol M., Campbell L., Starr T., Roberts B., Wibrow B., Warhurst T., Chinthamuneedi M., Ferney B. B., Simon M., De Backer, D. Wittebole, De Bels, D. Collin, V. Dams, K. Jorens, P. Dubois, J. Gunst, J. Haentjens, De Schryver, N. Dugernier, T. Rezende-Neto, J. Rizoli, S. Santillan, P. Han, Y. Biskup, E. Qu, C. Li, X. Yu, T. Weihua, L. Molano-Franco, D. Rojas, J. Oviedo, J. M. P. Pinilla, D. Cardenas, Y. Celis, E. Arias, M. Vukovic, A. Vudrag, M. Belavic, M. Zunic, J. Kuharic, J. Kricka, I. B. Filipovic-Grcic, I. Tomasevic, B. Obraz, M. Bodulica, B. Dohnal, M. Malaska, J. Kratochvil, M. Satinsky, I. Schwarz, P. Kos, Z. Blahut, L. Maca, J. Protus, M. Kieslichová, E. Nielsen, L. G. Krogh, B. M. Rivadeneira, F. Morales, F. Mora, J. Orozco, A. S. MorochoTutillo, D. R. Vargas, N. R. Yepez, E. S. Villamagua, B. Alsisi, A. Fahmy, A. Dupont, H. Lasocki, S. Paugam-Burtz, C. Foucrier, A. Nica, A. Barjon, G. Mallat, J. Marcotte, G. Leone, M. Duclos, G. Burtin, P. Atchade, E. Mahjoub, Y. Misset, B. Timsit, J. -F., Dupuis C., Veber B., Debarre M., Collange O., Pottecher J., Hecketsweiler S., Fromentin M., Tesnière A., Koch C., Sander M., Elke G., Wrigge H., Simon P., Chalkiadaki A., Tzanidakis C., Pneumatikos I., Sertaridou E., Mastora Z., Pantazopoulos I., Papanikolaou M., Papavasilopoulou T., Floros J., Kolonia V., Diakaki C., Rallis M., Paridou A., Kalogeromitros A., Romanou V., Nikolaou C., Kounougeri K., Tsigou E., Psallida V., Karampela N., Mandragos K., Kontoudaki E., Pentheroudaki A., Farazi-Chongouki C., Karakosta A., Chouris I., Radu V., Malliotakis P., Kokkini S., Charalambous E., Kyritsi A., Koulouras V., Papathanakos G., Nagky E., Lampiri C., Tsimpoukas F., Sarakatsanos I., Georgakopoulos P., Ravani I., Prekates A., Sakellaridis K., Christopoulos C., Vrettou E., Stokkos K., Pentari A., Marmanidou K., Kydona C., Tsoumaropoulos G., Bitzani M., Kontou P., Voudouris A., Elli-Nikki Flioni, Antypa E., Chasou E., Anisoglou S., Papageorgiou E., Paraforou T., Tsioka A., Karathanou A., Vakalos A., Shah B., Thakkar C., Jain N., Gurjar M., Baronia A., Sathe P., Kulkarni S., Paul C., Paul J., Masjedi M., Nikandish R., Zand F., Sabetian G., Mahmoodpoor A., Hashemian S. M., Bala M., Flocco R., Torrente S., Pota V., Spadaro S., Volta C., Serafini G., Boraso S., Tiberio I., Cortegiani A., Misseri G., Barbagallo M., Nicolotti D., Forfori F., Corradi F., De Pascale, G. Pelagalli, L. Brazzi, L. Vittone, F. G. Russo, A. Simion, D. Cotoia, A. Cinnella, G. Toppin, P. Johnson-Jackson, R. Hayashi, Y. Yamamoto, R. Yasuda, H. Kishihara, Y. Shiotsuka, J. Sanchez-Hurtado, L. A. Tejeda-Huezo, B. Gorordo, L. Ñamendys-Silva, S. A. Garcia-Guillen, F. J. Martinez, M. Romero-Meja, E. Colorado-Dominguez, van den Oever, H. Kalff, K. M. Vermeijden, W. Cornet, A. D. Beck, O. Cimic, N. Dormans, T. Bormans, L. Bakker, Van Duijn, D. Bosman, G. Vos, P. Haas, L. Henein, A. Miranda, A. M. Makikado, L. D. U. Malca, G. E. G. Arroyo-Sanchez, A. Misiewska-Kaczur, A. Akinyi, F. Czuczwar, M. Luczak, K. Sulkowski, W. Tamowicz, B. Swit, B. Baranowski, B. Smuszkiewicz, P. Trojanowska, I. Rzymski, S. Sawinski, M. Trosiak, M. Mikaszewska-Sokolewicz, M. Alves, R. Leal, D. Krystopchuk, A. Mendonca, P. M. H. Pereira, R. A., de Carvalho, M. R. L. M. Candeias, C. Molinos, E. Ferreira, A. Castro, G. Pereira, J. -M., Santos L., Ferreira A., Pascoalinho D., Ribeiro R., Domingos G., Gomes P., Nora D., Costa R. P., Santos A., Alsheikhly A. S., Popescu M., Grigoras I., Patrascanu E., Zabolotskikh I., Musaeva T., Gaigolnik D., Kulabukhov V., Belskiy V., Zubareva N., Tribulev M., Abdelsalam A., Aldarsani A., Al-Khalid M., Almekhlafi G., Mandourah Y., Doklestic K., Velickovic J., Velickovic D., Jankovic R., Vukovic A., Skoric-Jokic S., Radovanovic D., Richards G., Alli A., del Carmen Cordoba Nielfa, M. Iniesta, R. S. Martínez, A. B. -C., Bernedo C. G., Gil S. A. P., Nuvials X., Garcia J. G., Peña J. M. G., Jimenez R., Herrera L., Barrachina L. G., Monzon I. C., Redondo F. J., Villazala R., Zapata D. F. M., Lopez I. M. V., Moreno-Gonzalez G., Lopez-Delgado J. C., Marin J. S., Sanchez-Zamora P., Vidal M. V., González J. F., Salinas I., Hermosa C., Martinez-Sagasti F., Domingo-Marín S., Victorino J. A., Garcia-Alvarez R., Calleja, P. L. -A., de la Torre-Prados, M. -V., Vidal-Cortes P., del Río-Carbajo, L. Izura, J. Minguez, V. Alvarez, J. T. Prous, A. P. Paz, D. Roche-Campo, F. Aguilar, G. Belda, J. Rico-Feijoo, J. Aldecoa, C. Zalba-Etayo, B. Lang, M. Dullenkopf, A. Trongtrakul, K. Chtsomkasem, A. Akbas, T. Unal, M. N. Ozcelik, M. Gumus, A. Ramazanoglu, A. Memis, D. Mehmet, I. Urkmez, S. Ozgultekin, A. Demirkiran, O. Aslan, N. A. Kizilaslan, D. Kahveci, F. Ünlü, N. Ozkan, Z. Kaye, C. Jansen, J. O’Neill, O. Nutt, C. Jha, R. Hooker, N. Grecu, I. Petridou, C. Shyamsundar, M. McNamee, L. Trinder, J. Hagan, S. Kelly, C. Silversides, J. Groba, C. B. Boyd, O. Bhowmick, K. Humphreys, S. Summers, C. Polgarova, P. Margarson, M. Dickens, J. Pearson, S. Chinery, E. Hemmings, N. O’Kane, S. Austin, P. Cole, S. Plowright, C. Box, R. Wright, C. Young, L. Montague, L. Parker, R. Morton, B. Ostermann, M. Bilinska, J. Rose, B. O. Reece-Anthony, R. Ryan, C. Hamilton, M. Hopkins, P. Wendon, J. Brescia, G. Ijaz, N. Wood, J. George, M. Toth-Tarsoly, P. Yates, B. Armstrong, M. Scott, C. Boyd, C. Szakmany, T. Rees, D. Pulak, P. Coggon, M. Saha, B. Kent, L. Gibson, B. Camsooksai, J. Reschreiter, H. Morgan, P. Sangaralingham, S. Lowe, A. Vondras, P. Jamadarkhana, S. Cruz, C. Bhandary, R. Hersey, P. Furneval, J. Innes, R. Doble, P. Attwood, B. Parsons, P. Page, V. Zhao, X. Grecu, I. Dalton, J. Hegazy, M. Awad, Y. Naylor, D. Naylor, A. Lee, S. Brevard, S. Davis, University of Queensland [Brisbane], Department of Intensive Care and Anesthesiology, Università cattolica del Sacro Cuore [Milano] (Unicatt), University Medical Center [Utrecht], Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Département d'Anesthésie Réanimation, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centro Hospitalar Universitário São João - Faculty of Medicine - University of Porto - Grupo de Infecção e Sepsis, Porto, Critical Care Department, Joan XXIII University Hospital, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, European Soc Intensive Care Med, İÜC, Cerrahpaşa Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, [Blot S, Blot K] Department of Internal Medicine and Pediatrics, Ghent University, Campus UZ Gent, Ghent, Belgium. [Antonelli M] Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Università Cattolica del Sacro Cuore, Rome, Italy. [Arvaniti K] Intensive Care Unit, Papageorgiou University Affiliated Hospital, Thessaloníki, Greece. [Creagh-Brown, B] Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group (SPACeR), Royal Surrey County Hospital, Guildford, UK. Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. [de Lange D] Department of Intensive Care Medicine, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands. [Rello J] Centro de investigación en red de enfermedades respiratorias (CIBERES), Madrid, Spain. Recerca clínica/Innovació en la pneumònia i sèpsia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Ünlü, Nurdan, Kahveci, Ferda, CYR-2043-2022, CHB-0826-2022, Assistance Publique-Hôpitaux de Marseille (AP-HM), Blot S., Antonelli M., Arvaniti K., Blot K., Creagh-Brown B., de Lange D., De Waele J., Deschepper M., Dikmen Y., Dimopoulos G., Eckmann C., Francois G., Girardis M., Koulenti D., Labeau S., Lipman J., Lipovestky F., Maseda E., Montravers P., Mikstacki A., Paiva J.-A., Pereyra C., Rello J., Timsit J.-F., Vogelaers D., Lamrous A., Rezende-Neto J., Cardenas Y., Vymazal T., Fjeldsoee-Nielsen H., Kott M., Kostoula A., Javeri Y., Einav S., Makikado L.D.U., Tomescu D., Gritsan A., Jovanovic B., Venkatesan K., Mirkovic T., Emmerich M., Canale M., Dietz L.S., Ilutovich S., Minope J.T.S., Silva R.B., Montenegro M.A., Martin P., Saul P., Chediack V., Sutton G., Couce R., Balasini C., Gonzalez S., Lascar F.M., Descotte E.J., Gumiela N.S., Pino C.A., Cesio C., Valgolio E., Cunto E., Dominguez C., Nelson N.F., Abegao E.M., Pozo N.C., Bianchi L., Correger E., Pastorino M.L., Miyazaki E.A., Grubissich N., Garcia M., Bonetto N., Quevedo N.E., Gomez C.D., Queti F., Estevarena L.G., Fernandez R., Santolaya I., Grangeat S.H., Doglia J., Zakalik G., Pellegrini C., Lloria M.M., Chacon M.E., Fumale M., Leguizamon M., Hidalgo I.B., Tiranti R.J., Capponi P., Tita A., Cardonnet L., Bettini L., Ramos A., Lovesio L., Miranda E.M., Farfan A.B., Tolosa C., Segura L., Bellocchio A., Alvarez B., Manzur A., Lujan R., Fernandez N., Scarone N., Zazu A., Groh C., Fletcher J., Smith J., Azad R., Chavan N., Wong H., Kol M., Campbell L., Starr T., Roberts B., Wibrow B., Warhurst T., Chinthamuneedi M., Ferney B.B., Simon M., De Backer D., Wittebole X., De Bels D., Collin V., Dams K., Jorens P., Dubois J., Gunst J., Haentjens L., De Schryver N., Dugernier T., Rizoli S., Santillan P., Han Y., Biskup E., Qu C., Li X., Yu T., Weihua L., Molano-Franco D., Rojas J., Oviedo J.M.P., Pinilla D., Celis E., Arias M., Vukovic A., Vudrag M., Belavic M., Zunic J., Kuharic J., Kricka I.B., Filipovic-Grcic I., Tomasevic B., Obraz M., Bodulica B., Dohnal M., Malaska J., Kratochvil M., Satinsky I., Schwarz P., Kos Z., Blahut L., Maca J., Protus M., Kieslichova E., Nielsen L.G., Krogh B.M., Rivadeneira F., Morales F., Mora J., Orozco A.S., MorochoTutillo D.R., Vargas N.R., Yepez E.S., Villamagua B., Alsisi A., Fahmy A., Dupont H., Lasocki S., Paugam-Burtz C., Foucrier A., Nica A., Barjon G., Mallat J., Marcotte G., Leone M., Duclos G., Burtin P., Atchade E., Mahjoub Y., Misset B., Dupuis C., Veber B., Debarre M., Collange O., Pottecher J., Hecketsweiler S., Fromentin M., Tesniere A., Koch C., Sander M., Elke G., Wrigge H., Simon P., Chalkiadaki A., Tzanidakis C., Pneumatikos I., Sertaridou E., Mastora Z., Pantazopoulos I., Papanikolaou M., Papavasilopoulou T., Floros J., Kolonia V., Diakaki C., Rallis M., Paridou A., Kalogeromitros A., Romanou V., Nikolaou C., Kounougeri K., Tsigou E., Psallida V., Karampela N., Mandragos K., Kontoudaki E., Pentheroudaki A., Farazi-Chongouki C., Karakosta A., Chouris I., Radu V., Malliotakis P., Kokkini S., Charalambous E., Kyritsi A., Koulouras V., Papathanakos G., Nagky E., Lampiri C., Tsimpoukas F., Sarakatsanos I., Georgakopoulos P., Ravani I., Prekates A., Sakellaridis K., Christopoulos C., Vrettou E., Stokkos K., Pentari A., Marmanidou K., Kydona C., Tsoumaropoulos G., Bitzani M., Kontou P., Voudouris A., Elli-Nikki, Flioni, Antypa E., Chasou E., Anisoglou S., Papageorgiou E., Paraforou T., Tsioka A., Karathanou A., Vakalos A., Shah B., Thakkar C., Jain N., Gurjar M., Baronia A., Sathe P., Kulkarni S., Paul C., Paul J., Masjedi M., Nikandish R., Zand F., Sabetian G., Mahmoodpoor A., Hashemian S.M., Bala M., Flocco R., Torrente S., Pota V., Spadaro S., Volta C., Serafini G., Boraso S., Tiberio I., Cortegiani A., Misseri G., Barbagallo M., Nicolotti D., Forfori F., Corradi F., De Pascale G., Pelagalli L., Brazzi L., Vittone F.G., Russo A., Simion D., Cotoia A., Cinnella G., Toppin P., Johnson-Jackson R., Hayashi Y., Yamamoto R., Yasuda H., Kishihara Y., Shiotsuka J., Sanchez-Hurtado L.A., Tejeda-Huezo B., Gorordo L., Namendys-Silva S.A., Garcia-Guillen F.J., Martinez M., Romero-Meja E., Colorado-Dominguez E., van den Oever H., Kalff K.M., Vermeijden W., Cornet A.D., Beck O., Cimic N., Dormans T., Bormans L., Bakker J., Van Duijn D., Bosman G., Vos P., Haas L., Henein A., Miranda A.M., Malca G.E.G., Arroyo-Sanchez A., Misiewska-Kaczur A., Akinyi F., Czuczwar M., Luczak K., Sulkowski W., Tamowicz B., Swit B., Baranowski B., Smuszkiewicz P., Trojanowska I., Rzymski S., Sawinski M., Trosiak M., Mikaszewska-Sokolewicz M., Alves R., Leal D., Krystopchuk A., Mendonca P.M.H., Pereira R.A., de Carvalho M.R.L.M., Candeias C., Molinos E., Ferreira A., Castro G., Pereira J.-M., Santos L., Pascoalinho D., Ribeiro R., Domingos G., Gomes P., Nora D., Costa R.P., Santos A., Alsheikhly A.S., Popescu M., Grigoras I., Patrascanu E., Zabolotskikh I., Musaeva T., Gaigolnik D., Kulabukhov V., Belskiy V., Zubareva N., Tribulev M., Abdelsalam A., Aldarsani A., Al-Khalid M., Almekhlafi G., Mandourah Y., Doklestic K., Velickovic J., Velickovic D., Jankovic R., Skoric-Jokic S., Radovanovic D., Richards G., Alli A., del Carmen Cordoba Nielfa M., Iniesta R.S., Martinez A.B.-C., Bernedo C.G., Gil S.A.P., Nuvials X., Garcia J.G., Pena J.M.G., Jimenez R., Herrera L., Barrachina L.G., Monzon I.C., Redondo F.J., Villazala R., Zapata D.F.M., Lopez I.M.V., Moreno-Gonzalez G., Lopez-Delgado J.C., Marin J.S., Sanchez-Zamora P., Vidal M.V., Gonzalez J.F., Salinas I., Hermosa C., Martinez-Sagasti F., Domingo-Marin S., Victorino J.A., Garcia-Alvarez R., Calleja P.L.-A., de la Torre-Prados M.-V., Vidal-Cortes P., del Rio-Carbajo L., Izura J., Minguez V., Alvarez J.T., Prous A.P., Paz D., Roche-Campo F., Aguilar G., Belda J., Rico-Feijoo J., Aldecoa C., Zalba-Etayo B., Lang M., Dullenkopf A., Trongtrakul K., Chtsomkasem A., Akbas T., Unal M.N., Ozcelik M., Gumus A., Ramazanoglu A., Memis D., Mehmet I., Urkmez S., Ozgultekin A., Demirkiran O., Aslan N.A., Kizilaslan D., Kahveci F., Unlu N., Ozkan Z., Kaye C., Jansen J., O'Neill O., Nutt C., Jha R., Hooker N., Grecu I., Petridou C., Shyamsundar M., McNamee L., Trinder J., Hagan S., Kelly C., Silversides J., Groba C.B., Boyd O., Bhowmick K., Humphreys S., Summers C., Polgarova P., Margarson M., Dickens J., Pearson S., Chinery E., Hemmings N., O'Kane S., Austin P., Cole S., Plowright C., Box R., Wright C., Young L., Montague L., Parker R., Morton B., Ostermann M., Bilinska J., Rose B.O., Reece-Anthony R., Ryan C., Hamilton M., Hopkins P., Wendon J., Brescia G., Ijaz N., Wood J., George M., Toth-Tarsoly P., Yates B., Armstrong M., Scott C., Boyd C., Szakmany T., Rees D., Pulak P., Coggon M., Saha B., Kent L., Gibson B., Camsooksai J., Reschreiter H., Morgan P., Sangaralingham S., Lowe A., Vondras P., Jamadarkhana S., Cruz C., Bhandary R., Hersey P., Furneval J., Innes R., Doble P., Attwood B., Parsons P., Page V., Zhao X., Dalton J., Hegazy M., Awad Y., Naylor D., Naylor A., Lee S., Brevard S., Davis N., Blot, Stijn [0000-0003-2145-0345], Apollo - University of Cambridge Repository, Gunst, Jan, Epidemiology, Intensive Care, Blot, S., aEmail Author, Antonelli, M. b., C, Arvaniti, Blot, K. d., Creagh-Brown, K. a., B. e., F, De, Lange, D., G., De, Waele, Deschepper, J. h., Dikmen, M. i., Dimopoulos, Y. j., Eckmann, G. k., Francois, C. l., Girardis, G. m., Koulenti, M. n., D. o., P, Labeau, S. a., Q, Lipman, J. r., S, Lipovestky, F. t., Maseda, E. u., Montravers, P. v., W, Mikstacki, A. x., Y, Paiva, J. -A., Z., Pereyra, C., Aa, Rello, J., Ab, Timsit, J. -F., Ac, Ad, Vogelaer, D., Ae, Lamrous, A., Rezende-Neto, J., Cardenas, Y., Vymazal, T., Fjeldsoee-Nielsen, H., Kott, M., Kostoula, A., Javeri, Y., Einav, S., Makikado, L. D. U., Tomescu, D., Gritsan, A., Jovanovic, B., Venkatesan, K., Mirkovic, T., Creagh-Brown, B., Emmerich, M., Canale, M., Dietz, L. S., Ilutovich, S., Miñope, J. T. S., Silva, R. B., Montenegro, M. A., Martin, P., Saul, P., Chediack, V., Sutton, G., Couce, R., Balasini, C., Gonzalez, S., Lascar, F. M., Descotte, E. J., Gumiela, N. S., Pino, C. A., Cesio, C., Valgolio, E., Cunto, E., Dominguez, C., Nelson, N. F., Abegao, E. M., Pozo, N. C., Bianchi, L., Correger, E., Pastorino, M. L., Miyazaki, E. A., Grubissich, N., Garcia, M., Bonetto, N., Quevedo, N. E., Gomez, C. D., Queti, F., Estevarena, L. G., Fernandez, R., Santolaya, I., Grangeat, S. H., Doglia, J., Zakalik, G., Pellegrini, C., Lloria, M. M., Chacon, M. E., Fumale, M., Leguizamon, M., Hidalgo, I. B., Tiranti, R. J., Capponi, P., Tita, A., Cardonnet, L., Bettini, L., Ramos, A., Lovesio, L., Miranda, E. M., Farfan, A. B., Tolosa, C., Segura, L., Bellocchio, A., Alvarez, B., Manzur, A., Lujan, R., Fernandez, N., Scarone, N., Zazu, A., Groh, C., Fletcher, J., Smith, J., Azad, R., Chavan, N., Wong, H., Kol, M., Campbell, L., Starr, T., Roberts, B., Wibrow, B., Warhurst, T., Chinthamuneedi, M., Ferney, B. B., Simon, M., De, Backer, D., Wittebole, De, Bel, D., Collin, V., Dam, K., Joren, P., Duboi, J., Gunst, J., Haentjen, De, Schryver, N., Dugernier, T., Rezende-Neto, J., Rizoli, S., Santillan, P., Han, Y., Biskup, E., Qu, C., Li, X., Yu, T., Weihua, L., Molano-Franco, D., Roja, J., Oviedo, J. M. P., Pinilla, D., Cardena, Y., Celi, E., Aria, M., Vukovic, A., Vudrag, M., Belavic, M., Zunic, J., Kuharic, J., Kricka, I. B., Filipovic-Grcic, I., Tomasevic, B., Obraz, M., Bodulica, B., Dohnal, M., Malaska, J., Kratochvil, M., Satinsky, I., Schwarz, P., Ko, Z., Blahut, L., Maca, J., Protu, M., Kieslichová, E., Nielsen, L. G., Krogh, B. M., Rivadeneira, F., Morale, F., Mora, J., Orozco, A. S., Morochotutillo, D. R., Varga, N. R., Yepez, E. S., Villamagua, B., Alsisi, A., Fahmy, A., Dupont, H., Lasocki, S., Paugam-Burtz, C., Foucrier, A., Nica, A., Barjon, G., Mallat, J., Marcotte, G., Leone, M., Duclo, G., Burtin, P., Atchade, E., Mahjoub, Y., Misset, B., Timsit, J., -F., Dupuis, C., Veber, B., Debarre, M., Collange, O., Pottecher, J., Hecketsweiler, S., Fromentin, M., Tesnière, A., Koch, C., Sander, M., Elke, G., Wrigge, H., Simon, P., Chalkiadaki, A., Tzanidakis, C., Pneumatikos, I., Sertaridou, E., Mastora, Z., Pantazopoulos, I., Papanikolaou, M., Papavasilopoulou, T., Floros, J., Kolonia, V., Diakaki, C., Rallis, M., Paridou, A., Kalogeromitros, A., Romanou, V., Nikolaou, C., Kounougeri, K., Tsigou, E., Psallida, V., Karampela, N., Mandragos, K., Kontoudaki, E., Pentheroudaki, A., Farazi-Chongouki, C., Karakosta, A., Chouris, I., Radu, V., Malliotakis, P., Kokkini, S., Charalambous, E., Kyritsi, A., Koulouras, V., Papathanakos, G., Nagky, E., Lampiri, C., Tsimpoukas, F., Sarakatsanos, I., Georgakopoulos, P., Ravani, I., Prekates, A., Sakellaridis, K., Christopoulos, C., Vrettou, E., Stokkos, K., Pentari, A., Marmanidou, K., Kydona, C., Tsoumaropoulos, G., Bitzani, M., Kontou, P., Voudouris, A., Elli-Nikki, Flioni, Antypa, E., Chasou, E., Anisoglou, S., Papageorgiou, E., Paraforou, T., Tsioka, A., Karathanou, A., Vakalos, A., Shah, B., Thakkar, C., Jain, N., Gurjar, M., Baronia, A., Sathe, P., Kulkarni, S., Paul, C., Paul, J., Masjedi, M., Nikandish, R., Zand, F., Sabetian, G., Mahmoodpoor, A., Hashemian, S. M., Bala, M., Flocco, R., Torrente, S., Pota, V., Spadaro, S., Volta, C., Serafini, G., Boraso, S., Tiberio, I., Cortegiani, A., Misseri, G., Barbagallo, M., Nicolotti, D., Forfori, F., Corradi, F., De, Pascale, G., Pelagalli, L., Brazzi, L., Vittone, F. G., Russo, A., Simion, D., Cotoia, A., Cinnella, G., Toppin, P., Johnson-Jackson, R., Hayashi, Y., Yamamoto, R., Yasuda, H., Kishihara, Y., Shiotsuka, J., Sanchez-Hurtado, L. A., Tejeda-Huezo, B., Gorordo, L., Ñamendys-Silva, S. A., Garcia-Guillen, F. J., Martinez, M., Romero-Meja, E., Colorado-Dominguez, van den, Oever, H., Kalff, K. M., Vermeijden, W., Cornet, A. D., Beck, O., Cimic, N., Dorman, T., Borman, L., Bakker, Van, Duijn, D., Bosman, G., Vo, P., Haa, L., Henein, A., Miranda, A. M., Makikado, L. D. U., Malca, G. E. G., Arroyo-Sanchez, A., Misiewska-Kaczur, A., Akinyi, F., Czuczwar, M., Luczak, K., Sulkowski, W., Tamowicz, B., Swit, B., Baranowski, B., Smuszkiewicz, P., Trojanowska, I., Rzymski, S., Sawinski, M., Trosiak, M., Mikaszewska-Sokolewicz, M., Alve, R., Leal, D., Krystopchuk, A., Mendonca, P. M. H., Pereira, R., A., De, Carvalho, M. R. L. M., Candeia, C., Molino, E., Ferreira, A., Castro, G., Pereira, J., -M., Santos, L., Ferreira, A., Pascoalinho, D., Ribeiro, R., Domingos, G., Gomes, P., Nora, D., Costa, R. P., Santos, A., Alsheikhly, A. S., Popescu, M., Grigoras, I., Patrascanu, E., Zabolotskikh, I., Musaeva, T., Gaigolnik, D., Kulabukhov, V., Belskiy, V., Zubareva, N., Tribulev, M., Abdelsalam, A., Aldarsani, A., Al-Khalid, M., Almekhlafi, G., Mandourah, Y., Doklestic, K., Velickovic, J., Velickovic, D., Jankovic, R., Vukovic, A., Skoric-Jokic, S., Radovanovic, D., Richards, G., Alli, A., del Carmen Cordoba, Nielfa, M., Iniesta, R. S., Martínez, A. B., -C., Bernedo, C. G., Gil, S. A. P., Nuvials, X., Garcia, J. G., Peña, J. M. G., Jimenez, R., Herrera, L., Barrachina, L. G., Monzon, I. C., Redondo, F. J., Villazala, R., Zapata, D. F. M., Lopez, I. M. V., Moreno-Gonzalez, G., Lopez-Delgado, J. C., Marin, J. S., Sanchez-Zamora, P., Vidal, M. V., González, J. F., Salinas, I., Hermosa, C., Martinez-Sagasti, F., Domingo-Marín, S., Victorino, J. A., Garcia-Alvarez, R., Calleja, P. L., -A., de la, Torre-Prado, M., -V., Vidal-Cortes, P., Del, Río-Carbajo, L., Izura, J., Minguez, V., Alvarez, J. T., Prou, A. P., Paz, D., Roche-Campo, F., Aguilar, G., Belda, J., Rico-Feijoo, J., Aldecoa, C., Zalba-Etayo, B., Lang, M., Dullenkopf, A., Trongtrakul, K., Chtsomkasem, A., Akba, T., Unal, M. N., Ozcelik, M., Gumu, A., Ramazanoglu, A., Memi, D., Mehmet, I., Urkmez, S., Ozgultekin, A., Demirkiran, O., Aslan, N. A., Kizilaslan, D., Kahveci, F., Ünlü, N., Ozkan, Z., Kaye, C., Jansen, J., O’Neill, O., Nutt, C., Jha, R., Hooker, N., Grecu, I., Petridou, C., Shyamsundar, M., Mcnamee, L., Trinder, J., Hagan, S., Kelly, C., Silverside, J., Groba, C. B., Boyd, O., Bhowmick, K., Humphrey, S., Summer, C., Polgarova, P., Margarson, M., Dicken, J., Pearson, S., Chinery, E., Hemming, N., O’Kane, S., Austin, P., Cole, S., Plowright, C., Box, R., Wright, C., Young, L., Montague, L., Parker, R., Morton, B., Ostermann, M., Bilinska, J., Rose, B. O., Reece-Anthony, R., Ryan, C., Hamilton, M., Hopkin, P., Wendon, J., Brescia, G., Ijaz, N., Wood, J., George, M., Toth-Tarsoly, P., Yate, B., Armstrong, M., Scott, C., Boyd, C., Szakmany, T., Ree, D., Pulak, P., Coggon, M., Saha, B., Kent, L., Gibson, B., Camsooksai, J., Reschreiter, H., Morgan, P., Sangaralingham, S., Lowe, A., Vondra, P., Jamadarkhana, S., Cruz, C., Bhandary, R., Hersey, P., Furneval, J., Inne, R., Doble, P., Attwood, B., Parson, P., Page, V., Zhao, X., Grecu, I., Dalton, J., Hegazy, M., Awad, Y., Naylor, D., Naylor, A., Lee, S., Brevard, and S., Davis
- Subjects
Infection risk ,Male ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,Antibiotic resistance ,Tracte gastrointestinal - Malalties ,Definitions ,Critical Care and Intensive Care Medicine ,THERAPY ,DEFINITIONS ,Infections::Intraabdominal Infections [DISEASES] ,0302 clinical medicine ,Intensive care ,Intra-abdominal infection ,Mortality ,Multidrug resistance ,Peritonitis ,Sepsis ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Observational study ,Septic shock ,ComputingMilieux_MISCELLANEOUS ,Critical Illness/epidemiology ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,Intraabdominal Infections/epidemiology ,Abdominal infection ,Multicenter study ,3. Good health ,Management ,Clinical trial ,Cohort ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Cohort analysis ,Community acquired infection ,Cohort study ,Human ,medicine.medical_specialty ,Carbapenem resistance ,Critical Illness ,Peritoneal dialysis ,Vancomycin resistant enterococcus ,Major clinical study ,Article ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Settore MED/41 - ANESTESIOLOGIA ,Humans ,Critical care medicine ,Hospital infection ,Aged ,Science & Technology ,Liver failure ,Antibiotic therapy ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Epidemiologic Studies ,030228 respiratory system ,Intensive Care Unit ,Sepsis (Diptera) ,Septic Shock ,Risk factor ,Human medicine ,General & internal medicine ,Congestive heart failure ,Original ,Cohort Studies ,Risk Factors ,Cause of Death ,Epidemiology ,Prevalence ,Medicine and Health Sciences ,Abdominal abscess ,Sepsis/epidemiology ,Middle aged ,Antifungal therapy ,2. Zero hunger ,Peritoniti ,Antibiotic agent ,Biliary tract infection ,Middle Aged ,infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES] ,PREVALENCE ,Infections::Sepsis [DISEASES] ,técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Methicillin resistant staphylococcus aureus ,Raonament basat en casos ,Female ,Critically ill patient ,Life Sciences & Biomedicine ,Antifungal agent ,Adult ,Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Predictive value ,infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES] ,NO ,Critical Care Medicine ,Internal medicine ,General & Internal Medicine ,medicine ,MANAGEMENT ,Journal Article ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Septicèmia ,business.industry ,Pancreas disease ,Malnutrition ,030208 emergency & critical care medicine ,Typhlitis ,Toxic megacolon ,Intraabdominal Infections ,Therapy ,Late onset disorder ,business - Abstract
Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9289; Gunst, Jan/0000-0003-2470-6393; Vidal-Cortes, Pablo/0000-0003-0225-9975; Szakmany, Tamas/0000-0003-3632-8844; Dimopoulos, George/0000-0002-3784-3103; Rello, Jordi/0000-0003-0676-6210; U nal, Necmettin/0000-0002-9440-7893; Tiberio, Iolanda FLC/0000-0002-5662-7895; Cortegiani, Andrea/0000-0003-1416-9993; Morton, Ben/0000-0002-6164-2854; Labeau, Sonia/0000-0003-3863-612X; Velickovic, Dejan/0000-0002-7312-2880; Paul, John/0000-0002-9307-3465; Pereira, Rui/0000-0002-3010-8384; Silversides, Jon/0000-0002-9562-5462; Paiva, Jose-Artur/0000-0003-4323-0220; Smuszkiewicz, Piotr/0000-0003-3067-8229; Paul, Cherish/0000-0001-6133-0036; Santos, Lurdes/0000-0002-0622-6823; PANTAZOPOULOS, IOANNIS/0000-0002-8846-519X; Ostermann, Marlies/0000-0001-9500-9080; Blot, Stijn/0000-0003-2145-0345; Naylor, Amanda/0000-0002-6431-0230; Shyamsundar, Murali/0000-0003-3797-8080; Aldecoa, Cesar/0000-0001-8789-5959; Summers, Charlotte/0000-0002-7269-2873; biskup, ewelina/0000-0002-9871-927X; Cornet, Alexander/0000-0002-9917-5251; Trenado Alvarez, Jose/0000-0002-2930-0766; Volta, Carlo/0000-0003-3533-6121; Gritsan, Alexey/0000-0002-0500-2887; Urkmez, Seval/0000-0002-3412-4226 WOS:000493268200001 PubMed ID: 31664501 PurposeTo describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).MethodsWe performed a multicenter (n=309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.ResultsThe cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.ConclusionThis multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection. Pfizer investigator-initiated research grant AbSeS is a Trials Group Study of the European Society of Intensive Care Medicine. The study was supported by a Pfizer investigator-initiated research grant.
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- 2019
34. Accuracy and Feasibility of Real-time Continuous Glucose Monitoring in Critically Ill Patients After Abdominal Surgery and Solid Organ Transplantation.
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Voglová Hagerf B, Protus M, Nemetova L, Mraz M, Kieslichova E, Uchytilova E, Indrova V, Lelito J, Girman P, Haluzík M, Franekova J, Svirlochova V, Klonoff DC, Kohn MA, and Jabor A
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- Humans, Male, Middle Aged, Female, Aged, Abdomen surgery, Organ Transplantation, Feasibility Studies, Adult, Monitoring, Physiologic methods, Continuous Glucose Monitoring, Blood Glucose analysis, Critical Illness
- Abstract
Objective: Glycemia management in critical care is posing a challenge in frequent measuring and adequate insulin dose adjustment. In recent years, continuous glucose measurement has gained accuracy and reliability in outpatient and inpatient settings. The aim of this study was to assess the feasibility and accuracy of real-time continuous glucose monitoring (CGM) in ICU patients after major abdominal surgery., Research Design and Methods: We included patients undergoing pancreatic surgery and solid organ transplantation (liver, pancreas, islets of Langerhans, kidney) requiring an ICU stay after surgery. We used a Dexcom G6 sensor, placed in the infraclavicular region, for real-time CGM. Arterial blood glucose measured by the amperometric principle (ABL 800; Radiometer, Copenhagen, Denmark) served as a reference value and for calibration. Blood glucose was also routinely monitored by a StatStrip bedside glucose meter. Sensor accuracy was assessed by mean absolute relative difference (MARD), bias, modified Bland-Altman plot, and surveillance error grid for paired samples of glucose values from CGM and acid-base analyzer (ABL)., Results: We analyzed data from 61 patients and obtained 1,546 paired glucose values from CGM and ABL. Active sensor use was 95.1%. MARD was 9.4%, relative bias was 1.4%, and 92.8% of values fell in zone A, 6.1% fell in zone B, and 1.2% fell in zone C of the surveillance error grid. Median time in range was 78%, with minimum (<1%) time spent in hypoglycemia. StatStrip glucose meter MARD compared with ABL was 5.8%., Conclusions: Our study shows clinically applicable accuracy and reliability of Dexcom G6 CGM in postoperative ICU patients and a feasible alternative sensor placement site., (© 2024 by the American Diabetes Association.)
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- 2024
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35. Outcomes in Patients Perceived as Receiving Excessive Care by ICU Physicians and Nurses: Differences Between Patients < 75 and ≥ 75 Years of Age?
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Piers RD, Banner-Goodspeed V, Åkerman E, Kieslichova E, Meyfroidt G, Gerritsen RT, Uyttersprot E, and Benoit DD
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- Humans, Aged, Quality of Life, Intensive Care Units, Hospitalization, Physicians, Nurses
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Background: The benefit of the ICU for older patients is often debated. There is little knowledge on subjective impressions of excessive care in ICU nurses and physicians combined with objective patient data in real-life cases., Research Question: Is there a difference in treatment limitation decisions and 1-year outcomes in patients < 75 and ≥ 75 years of age, with and without concordant perceptions of excessive care by two or more ICU nurses and physicians?, Study Design and Methods: This was a reanalysis of the prospective observational DISPROPRICUS study, performed in 56 ICUs. Nurses and physicians completed a daily questionnaire about the appropriateness of care for each of their patients during a 28-day period in 2014. We compared the cumulative incidence of patients with concordant perceptions of excessive care, treatment limitation decisions, and the proportion of patients attaining the combined end point (death, poor quality of life, or not being at home) at 1 year across age groups via Cox regression with propensity score weighting and Fisher exact tests., Results: Of 1,641 patients, 405 (25%) were ≥ 75 years of age. The cumulative incidence of concordant perceptions of excessive care was higher in older patients (13.6% vs 8.5%; P < .001). In patients with concordant perceptions of excessive care, we found no difference between age groups in risk of death (1-year mortality, 83% in both groups; P > .99; hazard ratio [HR] after weighting, 1.11; 95% CI, 0.74-1.65), treatment limitation decisions (33% vs 31%; HR after weighting, 1.11; 95% CI, 0.69-2.17), and reaching the combined end point at 1 year (90% vs 93%; P = .546). In patients without concordant perceptions of excessive care, we found a difference in risk of death (1-year mortality, 41% vs 30%; P < .001; HR after weighting, 1.38; 95% CI, 1.11-1.73) and treatment limitation decisions (11% vs 5%; P < .001; HR, 2.11; 95% CI, 1.37-3.27); however, treatment limitation decisions were mostly documented prior to ICU admission. The risk of reaching the combined end point was higher in the older adults (61.6% vs 52.8%; P < .001)., Interpretation: Although the incidence of perceptions of excessive care is slightly higher in older patients, there is no difference in treatment limitation decisions and 1-year outcomes between older and younger patients once patients are identified by concordant perceptions of excessive care. Additionally, in patients without concordant perceptions, the outcomes are worse in the older adults, pleading against ageism in ICU nurses and physicians., (Copyright © 2023 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)
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- 2023
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36. Periprocedural safety profile of peroral endoscopic myotomy (POEM)-a retrospective analysis of adverse events according to two different classifications.
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Simkova D, Mares J, Vackova Z, Hucl T, Stirand P, Kieslichova E, Ryska O, Spicak J, Drazilova S, Veseliny E, and Martinek J
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- Humans, Retrospective Studies, Risk Factors, Treatment Outcome, Esophageal Sphincter, Lower surgery, Esophageal Achalasia surgery, Digestive System Surgical Procedures, Myotomy methods, Natural Orifice Endoscopic Surgery methods
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Background: Peroral endoscopic myotomy (POEM) is nowadays a standard method for treatment of achalasia; nevertheless, it remains an invasive intervention with corresponding risk of adverse events (AEs). The classification and grading of AEs are still a matter of discussion. The aim of our retrospective study was to assess the occurrence of all "undesirable" events and "true" adverse events in patients undergoing POEM and to compare the outcomes when either Clavien-Dindo classification (CDC) or American Society of Gastrointestinal Endoscopy (ASGE) lexicon classification applied., Methods: This was a retrospective analysis of prospectively managed database of all patients who had undergone POEM between December 2012 and August 2018. We assessed the pre-, peri-, and early-postoperative (up to patient's discharge) undesirable events (including those not fulfilling criteria for AEs) and "true" AEs according the definition in either of the classifications., Results: A total of 231 patients have successfully undergone 244 POEM procedures (13 × re-POEM). Twenty-nine procedures (11.9%) passed uneventfully, while in 215 procedures (88.1%), a total of 440 undesirable events occurred. The CDC identified 27 AEs (17 minor, 10 major) occurring in 23/244 (9.4%) procedures. The ASGE lexicon identified identical 27 AEs (21 mild or moderate, 6 severe or fatal) resulting in the severity distribution of AEs being the only difference between the two classifications. Only the absence of previous treatment was found to be a risk factor [p = 0.047, OR with 95% CI: 4.55 (1.02; 20.25)] in the combined logistic regression model., Conclusion: Undesirable events are common in patients undergoing POEM but the incidence of true AEs is low according to both classifications. Severe adverse events are infrequent irrespective of the classification applied. CDC may be more appropriate than ASGE lexicon for classifying POEM-related AEs given a surgical nature of this procedure., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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37. Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial.
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Martinek J, Hustak R, Mares J, Vackova Z, Spicak J, Kieslichova E, Buncova M, Pohl D, Amin S, and Tack J
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- Female, Gastric Emptying, Gastroscopy methods, Humans, Male, Prospective Studies, Treatment Outcome, Gastroparesis etiology, Gastroparesis surgery, Pyloromyotomy adverse effects, Pyloromyotomy methods
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Objective: Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients with gastroparesis., Design: In this prospective randomised trial, we compared G-POEM with a sham procedure in patients with severe gastroparesis. The primary outcome was the proportion of patients with treatment success (defined as a decrease in the Gastroparesis Cardinal Symptom Index (GCSI) by at least 50%) at 6 months. Patients randomised to the sham group with persistent symptoms were offered cross-over G-POEM., Results: The enrolment was stopped after the interim analysis by the Data and Safety Monitoring Board prior to reaching the planned sample of 86 patients. A total of 41 patients (17 diabetic, 13 postsurgical, 11 idiopathic; 46% male) were randomised (21 G-POEM, 20-sham). Treatment success rate was 71% (95% CI 50 to 86) after G-POEM versus 22% (8-47) after sham (p=0.005). Treatment success in patients with diabetic, postsurgical and idiopathic gastroparesis was 89% (95% CI 56 to 98), 50% (18-82) and 67% (30-90) after G-POEM; the corresponding rates in the sham group were 17% (3-57), 29% (7-67) and 20% (3-67).Median gastric retention at 4 hours decreased from 22% (95% CI 17 to 31) to 12% (5-22) after G-POEM and did not change after sham: 26% (18-39) versus 24% (11-35). Twelve patients crossed over to G-POEM with 9 of them (75%) achieving treatment success., Conclusion: In severe gastroparesis, G-POEM is superior to a sham procedure for improving both symptoms and gastric emptying 6 months after the procedure. These results are not entirely conclusive in patients with idiopathic and postsurgical aetiologies., Trial Registration Number: NCT03356067; ClinicalTrials.gov., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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38. Sepsis affects kidney graft function and one-year mortality of the recipients in contrast with systemic inflammatory response.
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Protus M, Uchytilova E, Indrova V, Lelito J, Viklicky O, Hruba P, and Kieslichova E
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Background: Infections remain a major cause of morbidity and mortality after kidney transplantation. The aim of our study was to determine the effect of sepsis on kidney graft function and recipient mortality., Methods: A prospective, observational, single-center study was performed. Selected clinical and biochemical parameters were recorded and compared between an experimental group (with sepsis, n = 34) and a control group (with systemic inflammatory response syndrome, n = 31) comprising kidney allograft recipients., Results: Sepsis worsened both patient (HR = 14.77, p = 0.007) and graft survival (HR = 15.07, p = 0.007). Overall one-year mortality was associated with age (HR = 1.08, p = 0.048), APACHE II score (HR = 1.13, p = 0.035), and combination immunosuppression therapy (HR = 0.1, p = 0.006), while graft survival was associated with APACHE II (HR = 1.25, p = 0.004) and immunosuppression. In sepsis patients, mortality correlated with the maximal dose of noradrenalin (HR = 100.96, p = 0.008), fungal infection (HR = 5.64, p = 0.024), SAPS II score (HR = 1.06, p = 0.033), and mechanical ventilation (HR = 5.97, p = 0.033), while graft survival was influenced by renal replacement therapy (HR = 21.16, p = 0.005), APACHE II (HR = 1.19, p = 0.035), and duration of mechanical ventilation (HR = 1.01, p = 0.015)., Conclusion: In contrast with systemic inflammatory response syndrome, septic kidney allograft injury is associated with early graft loss and may represent a significant risk of mortality., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Protus, Uchytilova, Indrova, Lelito, Viklicky, Hruba and Kieslichova.)
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- 2022
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39. Portal hypertension is the main driver of liver stiffness in advanced liver cirrhosis.
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Lunova M, Frankova S, Gottfriedova H, Senkerikova R, Neroldova M, Kovac J, Kieslichova E, Lanska V, Sticova E, Spicak J, Jirsa M, and Sperl J
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- Adult, Aged, Collagen analysis, Elasticity Imaging Techniques, Female, Humans, Hypertension, Portal diagnosis, Hypertension, Portal surgery, Liver chemistry, Liver diagnostic imaging, Liver surgery, Liver Cirrhosis metabolism, Liver Cirrhosis physiopathology, Liver Cirrhosis surgery, Liver Transplantation, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Young Adult, Hypertension, Portal physiopathology, Liver pathology, Liver Cirrhosis pathology, Portal Pressure
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Liver stiffness (LS) is a novel non-invasive parameter widely used in clinical hepatology. LS correlates with liver fibrosis stage in non-cirrhotic patients. In cirrhotic patients it also shows good correlation with Hepatic Venous Pressure Gradient (HVPG). Our aim was to assess the contribution of liver fibrosis and portal hypertension to LS in patients with advanced liver cirrhosis. Eighty-one liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG and LS measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France). Liver collagen content was assessed in the explanted liver as collagen proportionate area (CPA) and hydroxyproline content (HP). The studied cohort included predominantly patients with Child-Pugh class B and C (63/81, 77.8%), minority of patients were Child-Pugh A (18/81, 22.2%). LS showed the best correlation with HVPG (r=0.719, p< 0.001), correlation of LS with CPA (r=0.441, p< 0.001) and HP/Amino Acids (r=0.414, p< 0.001) was weaker. Both variables expressing liver collagen content showed good correlation with each other (r=0.574, p<0.001). Multiple linear regression identified the strongest association between LS and HVPG (p < 0.0001) and weaker association of LS with CPA (p = 0.01883). Stepwise modelling showed minimal increase in r2 after addition of CPA to HVPG (0.5073 vs. 0.5513). The derived formula expressing LS value formation is: LS = 2.48 + (1.29 x HVPG) + (0.26 x CPA). We conclude that LS is determined predominantly by HVPG in patients with advanced liver cirrhosis whereas contribution of liver collagen content is relatively low.
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- 2021
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40. Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis.
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Frankova S, Lunova M, Gottfriedova H, Senkerikova R, Neroldova M, Kovac J, Kieslichova E, Lanska V, Urbanek P, Spicak J, Jirsa M, and Sperl J
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- Adult, Aged, Aged, 80 and over, Biomarkers blood, Czech Republic, Female, Fibrosis pathology, Hepatic Veins pathology, Humans, Hypertension, Portal pathology, Linear Models, Liver Cirrhosis pathology, Male, Middle Aged, Portal Pressure physiology, Prospective Studies, Sensitivity and Specificity, Venous Pressure physiology, Elasticity physiology, Elasticity Imaging Techniques methods, Liver pathology
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Liver stiffness is a reliable non-invasive predictor of Hepatic Venous Pressure Gradient (HVPG) above 10 mm Hg. However, it failed to predict higher thresholds of HVPG. Our aim was to investigate whether liver stiffness and selected previously published non-invasive blood biomarkers could predict higher HVPG thresholds in liver transplant candidates without ongoing alcohol use. One hundred and nine liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG measurement, liver stiffness measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France) and assessment of blood HVPG biomarkers (osteopontin, VCAM-1, IL-6, TNF-α, IL-1ra/IL-1F3 and ELF score). The correlation between liver stiffness and HVPG was linear up to 30 mm Hg of HVPG (r = 0.765, p < 0.0001). The regression lines had similar slopes for HVPG values below and above 16 mm Hg (p > 0.05) and the correlation in patients with HVPG <16 mm Hg (r = 0.456, p = 0.01) was similar to patients with HVPG ≥ 16 mm Hg (r = 0.499, p < 0.0001). The correlation was similar in the subgroup patients with alcoholic (r = 0.718, p < 0.0001), NASH (r = 0.740, p = 0.008), cryptogenic (r = 0.648, p = 0,0377), cholestatic and autoimmune (r = 0.706, p < 0.0001) and viral cirrhosis (r = 0.756, p < 0.0001). Liver stiffness distinguished patients with HVPG above 16, and 20 mm Hg with AUROCs 0.90243, and 0.86824, sensitivity 0.7656, and 0.7027, and specificity 0.9333, and 0.8750. All studied blood biomarkers correlated better with liver stiffness than with HVPG and their AUROCs did not exceed 0.8 at both HVPG thresholds. Therefore, a composite predictor superior to liver stiffness could not be established. We conclude that liver stiffness is a clinically reliable predictor of higher HVPG thresholds in non-drinking subjects with advanced liver cirrhosis., Competing Interests: The authors have declared that no competing interests exist.
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- 2021
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41. Cardiac arrest as a fatal periprocedural complication of peroral endoscopic myotomy (POEM).
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Hucl T, Uchytilova E, Markvartova J, Tomasek P, Kieslichova E, Spicak J, and Martinek J
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- Humans, Treatment Outcome, Digestive System Surgical Procedures, Esophageal Achalasia surgery, Heart Arrest etiology, Myotomy adverse effects, Natural Orifice Endoscopic Surgery
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Competing Interests: The authors declare that they have no conflict of interest.
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- 2020
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42. Single mutidrug resistant enterobacteriacae donor-derived infection in four solid organ transplant recipients: a case report.
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Kieslichova E, Protus M, Nemcova D, and Uchytilova E
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- Adult, Anti-Bacterial Agents therapeutic use, Escherichia coli drug effects, Escherichia coli Infections drug therapy, Female, Humans, Klebsiella Infections drug therapy, Klebsiella pneumoniae drug effects, Male, Middle Aged, Tissue and Organ Procurement, Transplant Recipients, Bacteremia, Drug Resistance, Multiple, Bacterial, Escherichia coli Infections diagnosis, Escherichia coli Infections microbiology, Klebsiella Infections diagnosis, Klebsiella Infections microbiology, Organ Transplantation adverse effects, Tissue Donors
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Background: Bacteraemia of the donor is not considered to be contraindication of organ procurement. On the other hand, infection of solid organ transplant recipients remains to be a major cause of their morbidity and mortality. When using organs from bacteraemic donors, individual risks need to be assessed and the appropriate antibiotic treatment applied., Case Presentation: In this case series we report several serious donor-derived infectious complications in four out of five recipients of different organs from one single donor in the early posttransplant period. Donor-transmitted multi-drug resistant strains of Escherichia coli and Klebsiella pneumonia was confirmed by both serologic and molecular testing., Conclusions: To prevent donor-derived infections, careful microbiological screening followed by targeted antibiotic treatment is essential. Although such complications can never by completely prevented, a high index for potential bacterial infection in organ donors and transplant recipients should be routinely employed.
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- 2019
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43. Erratum to: Per-oral endoscopic myotomy (POEM): mid-term efficacy and safety.
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Martinek J, Svecova H, Vackova Z, Dolezel R, Ngo O, Krajciova J, Kieslichova E, Janousek R, Pazdro A, Harustiak T, Zdrhova L, Loudova P, Stirand P, and Spicak J
- Abstract
The Given Names and Family Names were all inadvertently inverted. The correct order is: Jan Martinek, Hana Svecova, Zuzana Vackova, Radek Dolezel, Ondrej Ngo, Jana Krajciova, Eva Kieslichova, Radim Janousek, Alexander Pazdro, Tomas Harustiak, Lucie Zdrhova, Pavla Loudova, Petr Stirand, Julius Spicak. The original article was corrected.
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- 2018
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44. Per-oral endoscopic myotomy (POEM): mid-term efficacy and safety.
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Martinek J, Svecova H, Vackova Z, Dolezel R, Ngo O, Krajciova J, Kieslichova E, Janousek R, Pazdro A, Harustiak T, Zdrhova L, Loudova P, Stirand P, and Spicak J
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- Adolescent, Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Young Adult, Esophageal Achalasia surgery, Heller Myotomy methods, Natural Orifice Endoscopic Surgery methods
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Background and Aims: Per-oral endoscopic myotomy (POEM) is becoming a standard treatment for achalasia. Long-term efficacy and the rate of post-POEM reflux should be further investigated. The main aim of this study was to analyze safety and mid-term (12 and 24 months) clinical outcomes of POEM., Methods: Data on single tertiary center procedures were collected prospectively. The primary outcome was treatment success defined as an Eckardt score < 3 at 12 and 24 months. A total of 155 consecutive patients with achalasia underwent POEM; 133 patients were included into the analysis (22 patients will be analyzed separately as part of a multicenter randomized clinical trial)., Results: POEM was successfully completed in 132 (99.2%) patients, and the mean length of the procedure was 69.8 min (range 31-136). One patient underwent a drainage for pleural effusion; no other serious adverse events occurred. Treatment success at 3, 12, and 24 months was observed in 95.5% (CI 89.6-98.1), 93.4% (86.5-96.8), and 84.0% (71.4-91.4) of patients, respectively. A total of 11 patients (8.3%) reported initial treatment failure (n = 5) or later recurrence (n = 6). The majority of relapses occurred in patients with achalasia type I (16.7 vs. 1.1% achalasia type II vs. 0% achalasia type III; p<0.05). At 12 months, post-POEM reflux symptoms were present in 29.7% of patients. At 3 months, mild reflux esophagitis was diagnosed in 37.6% of patients, and pathological gastroesophageal reflux was detected in 41.5% of patients. A total of 37.8% of patients had been treated with a proton pump inhibitor., Conclusion: POEM resulted in greater than 90% treatment success at 12 months which tends to decrease to 84% after 2 years. More than one-third of the patients had mild reflux symptoms and/or mild esophagitis.
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- 2018
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45. Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES.
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Hucl T, Benes M, Kocik M, Splichalova A, Maluskova J, Krak M, Lanska V, Heczkova M, Kieslichova E, Oliverius M, and Spicak J
- Abstract
Aims. The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches. Methods. Thirty pigs were randomized to transgastric, transcolonic, or laparoscopic peritoneoscopy. Blood was drawn and analyzed for C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin- (IL-) 1β, IL-6, WBCs, and platelets. Results. Endoscopic closure with an OTSC was successful in all 20 animals. The postoperative course was uneventful in all animals. CRP values rose on day 1 in all animals and slowly declined to baseline levels on day 14 with no differences between the groups (P > 0.05, NS). The levels of TNF-α were significantly increased in the transcolonic group (P < 0.01); however this difference was already present prior to the procedure and remained unchanged. No differences were observed in IL1-β and IL-6 values. There was a temporary rise of WBC on day 1 and of platelets on day 7 in all groups (P > 0.05, NS). Conclusions. Transgastric, transcolonic, and laparoscopic peritoneoscopy resulted in similar changes in systemic inflammatory markers. Our findings do not support the assumption that NOTES is less invasive than laparoscopy.
- Published
- 2016
- Full Text
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46. Urgent liver transplantation for chemotherapy-induced HBV reactivation: a suitable option in patients recently treated for malignant lymphoma.
- Author
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Sperl J, Frankova S, Kieslichova E, Oliverius M, Janousek L, Honsova E, Trunecka P, and Spicak J
- Subjects
- Adult, DNA, Viral analysis, Female, Hepatitis B virus genetics, Hepatitis B virus physiology, Humans, Male, Middle Aged, Retrospective Studies, Antineoplastic Agents adverse effects, Hepatitis B virus drug effects, Liver Transplantation, Lymphoma drug therapy, Virus Activation
- Abstract
Background: Hepatitis B (HBV) reactivation induced by chemotherapy is a problem currently encountered in the management of malignancies. HBV reactivation occurs particularly in patients who were not checked for HBV status, and therefore have not undergone antiviral prophylaxis. HBV reactivation may ultimately lead to fulminant liver failure (FLF). Liver transplantation (OLT), the only remaining effective treatment option, is generally denied for subjects with a recent history of malignancy., Case Reports: We described retrospectively three cases of FLF caused by HBV reactivation in two men and one woman undergoing rituximab-containing chemotherapy for malignant lymphomas: follicular, diffuse large B-cell and lymphoplasmacytic types. The two men reactivated after eight cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone and the one woman after 13 cycles of rituximab monotherapy; their hematologic disease was in remission. All three patients were hepatitis B surface antigen (HBsAg)-positive with high HBV DNA levels. Neither man had been screened for HBV before chemotherapy; the woman had been treated with lamivudine (LAM) experiencing an HBV flare-up due to emergence of LAM resistance. All patients fulfilled King's College criteria for urgent OLT upon admission to the transplant center and underwent an urgent OLT. Their hemato-oncologic prognosis was considered to be favorable. All three patients are alive (54, 46, and 37 months post-transplantation), tumor-free and HBsAg negative on a standard HBV prophylaxis regimen: hepatitis B immunoglobulin and LAM + adefovir or tenofovir., Conclusions: Before chemotherapy appropriate prophylaxis for HBV reactivation should always be administered to at-risk patients. However, if reactivation with FLF occurs, OLT should not be generally denied. The prognosis of the hematologic malignancy should be assessed; OLT should be considered for patients in remission with a favorable long-term prognosis, for our data suggest acceptable survival., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
- Full Text
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47. A novel double-endoloop technique for natural orifice transluminal endoscopic surgery gastric access site closure.
- Author
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Hucl T, Benes M, Kocik M, Krak M, Maluskova J, Kieslichova E, Oliverius M, and Spicak J
- Subjects
- Animals, Female, Laparoscopes, Surgical Instruments, Swine, Gastrostomy instrumentation, Laparoscopy methods, Stomach surgery, Suture Techniques instrumentation, Wound Healing physiology
- Abstract
Background: Effective and safe access site closure is critical for clinical application of natural orifice transluminal endoscopic surgery., Objective: The current study evaluated a simple novel technique of gastrotomy closure., Design: Feasibility study with a survival animal model., Setting: Animal laboratory., Subjects: Ten female domestic pigs., Interventions: Endoscopic closure of a gastrotomy incision was evaluated in 10 pigs in a survival study. A standard double-channel endoscope was advanced into the peritoneal cavity through an incision made by a needle-knife and an 18-mm dilation balloon. After peritoneoscopy and salpingectomy, gastric closure was performed by using an endoscopic grasper and sequential application of 2 endoloops. After a follow-up period of 1 to 3 weeks, the pigs were killed for postmortem examination., Main Outcome Measurements: Feasibility, efficiency, and safety of a novel closure technique., Results: Correct positioning and delivery of endoloops was achieved in all animals in a median time of 17 minutes (range 13-25 minutes). All animals survived without complications. Postmortem examination demonstrated patent full-thickness gastric closure without any evidence of infection., Limitations: Feasibility study with a small number of subjects in a porcine model., Conclusion: Double endoloop technique represents a novel, simple, safe, and efficient means of gastric access site closure in natural orifice transluminal endoscopic surgery., (Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.)
- Published
- 2010
- Full Text
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48. Induction of procalcitonin in liver transplant patients treated with anti-thymocyte globulin.
- Author
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Zazula R, Prucha M, Tyll T, and Kieslichova E
- Subjects
- C-Reactive Protein metabolism, Calcitonin blood, Calcitonin Gene-Related Peptide, Humans, Postoperative Complications blood, Postoperative Complications prevention & control, Protein Precursors blood, Antilymphocyte Serum therapeutic use, Calcitonin biosynthesis, Immunosuppressive Agents therapeutic use, Liver Transplantation, Protein Precursors biosynthesis
- Abstract
Introduction: The aim of this study was to compare the early postoperative kinetics of procalcitonin (PCT) and C-reactive protein (CRP) serum levels in patients undergoing orthotopic liver transplantation (OLTx) with different immunosuppressive regimens., Methods: PCT and CRP serum concentrations were measured in a group of 28 OLTx recipients before induction of anesthesia, at 4 and 8 hours following graft reperfusion, and daily until postoperative day 4. The same parameters were determined in 12 patients undergoing liver resection without conjunctive immunosuppressive therapy. Summary data are expressed as medians and ranges. Two-tailed nonparametric tests were performed and considered significant at p values of less than 0.05., Results: The highest serum levels of PCT (median 3.0 ng/mL, minimum 1.4 ng/mL, maximum 13.9 ng/mL) were found in patients after OLTx without ATG therapy, on postoperative day 1. In patients with ATG administration, PCT levels were highly increased on postoperative day 1 (median 53.0 ng/mL, minimum 7.9 ng/mL, maximum 249.1 ng/mL). Thereafter, PCT values continuously decreased independently of further ATG administration in both groups of patients. No evidence of infection was present in either group. In 12 patients undergoing liver resection, peak serum PCT levels did not exceed 3.6 ng/mL. CRP serum levels in a group of patients with and without ATG therapy increased significantly on postoperative day 1, followed by a decrease. The highest levels of CRP were found in patients after liver resection on postoperative day 2 and decreased thereafter., Conclusion: ATG administration to patients with OLTx is associated with an increase in serum PCT levels, with peak values on postoperative day 1, and this was in the absence of any evidence of infection. The results of this study indicate that ATG immunosuppressive therapy is a stimulus for the synthesis of PCT.
- Published
- 2007
- Full Text
- View/download PDF
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