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Researchers from Khon Kaen University conducted a study on the double dehydration of sorbitol into isosorbide using a sulfonic acid resin as a catalyst. The study found that 100% conversion of sorbitol was achieved within 2 hours, with an isosorbide yield of about 78% after 4 hours. The research provides insights into the mechanism of this reaction, offering valuable information for catalyst and isosorbide production process design. The study was funded by the Research Center for Environmental and Hazardous Substance Management at Khon Kaen University and the National Science, Research, and Innovation Fund of Thailand. [Extracted from the article]

Researchers at Khon Kaen University in Thailand have developed a mucoadhesive gel containing a CBD-rich hemp extract for oromucosal delivery of CBD. The study compared nonaqueous and aqueous-based gels with different cosolvent contents and found that nonaqueous gels containing 40-100% propylene glycol exhibited the highest CBD release rate. The research provides valuable information for the development of oromucosal gels of phytocannabinoids and highlights the potential of nonaqueous-based gels for superior stability. [Extracted from the article]

Researchers from Khon Kaen University in Thailand conducted a study on the effect of different post and core materials on stress distribution in endodontically treated teeth without ferrule and with non-circular root canals. The study used finite element analysis to compare gold alloy, resin nanoceramic, PEEK, and PEKK materials, finding that resin nanoceramics showed even stress distribution and potential for mitigating root fracture and post debonding. This research, supported by the Faculty of Dentistry at Khon Kaen University, highlights the importance of material selection in dental restoration to improve outcomes for patients. [Extracted from the article]

Researchers at Khon Kaen University in Thailand conducted a study on enhancing multi-stress tolerance in Escherichia coli by expressing the Zymomonas mobilis recA gene. The study found that the recombinant strain showed increased survival rates under various stress conditions, including oxidative, heat, ethanol, and UV-C stresses. The research suggests that the RecA protein could have broad stress-protective functions across bacterial species and potential applications in developing stress-tolerant bacterial strains for biotechnological purposes. [Extracted from the article]

Researchers from Khon Kaen University in Thailand conducted a computational study on the use of cyclic peptide-modified gold nanoclusters for enhanced tumor-targeted bioimaging. The study focused on the impact of peptide modification on the optical and electronic properties of the nanoclusters, showing potential for improved photoluminescence and enhanced imaging contrast for integrin-overexpressing tumors. Funded by Khon Kaen University and the Science Achievement Scholarship of Thailand, this research highlights the promising applications of nanotechnology in theranostics. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand explored the role of Cyclin-dependent kinase inhibitor 3 (CDKN3) in Cholangiocarcinoma (CCA), a biliary tract tumor with high metastasis. The research found that CDKN3 acts as a tumor promoter, enhancing the proliferation of CCA cells. The study suggests that CDKN3 could be a potential target for therapy in CCA treatment, as silencing the gene decreased cell proliferation and enhanced the cytotoxic effect of gemcitabine therapy. [Extracted from the article]

Researchers from Khon Kaen University in Thailand conducted a study on cholangiocarcinoma, an aggressive cancer of the bile duct. They found that lenalidomide, a drug with anti-VEGF and anti-HIF1 alpha activities, showed promise in inhibiting tumor growth and angiogenesis in an in vivo mouse model. The study suggests that lenalidomide could be a potential treatment option for cholangiocarcinoma, but further investigation into its safety is needed. The research was supported by the Fundamental Fund of Khon Kaen University and has been peer-reviewed. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand focused on assessing the prevalence of dental and jaw abnormalities in pediatric thalassemia patients. The research found that malocclusion and small maxillary sinuses were more common in severe thalassemia patients and those with b-thalassemia. The study included 163 patients, with various abnormalities observed in a significant portion of the participants. This research provides valuable insights into the oral health challenges faced by pediatric thalassemia patients. [Extracted from the article]

Researchers from Khon Kaen University conducted a study on the anticancer activities of peanut testa extract in combination with cisplatin and 5-fluorouracil against cholangiocarcinoma cells. The study found that the peanut extract inhibited the proliferation of cancer cells more effectively than noncancer cells and induced apoptosis and cell cycle arrest. The researchers concluded that the peanut extract may be an effective synergistic agent with cisplatin and 5-fluorouracil for cholangiocarcinoma chemotherapy, warranting further clinical examination. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand focused on developing a solid self-microemulsifying drug delivery system for Kaempferia parviflora (KP) to address challenges related to its low water solubility and limited oral absorption. The research aimed to enhance the dissolution rate and bioavailability of methoxyflavones, the primary compound in KP, through the developed formulations. Results showed that the new delivery system significantly improved drug concentration and absorption in rats, without causing any acute toxicity. The study concluded that the KPS-SMEDDS formulation has the potential to enhance the absorption and bioavailability of methoxyflavones, making it a safe oral supplement. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand focused on the prevalence and predictors of malnutrition among individuals with dementia. The research included 61 pairs of older adults with dementia and their caregivers, revealing that 4.9% of patients had malnutrition and 34.4% were at risk. The study highlighted the importance of monitoring both the behavioral and psychological symptoms of dementia in patients and the nutritional status of their caregivers for comprehensive nutritional assessment. This peer-reviewed research emphasizes the need for regular monitoring to address malnutrition among individuals with dementia in Khon Kaen, Thailand. [Extracted from the article]

A study conducted by Khon Kaen University in Thailand analyzed the epidemiology and outcomes of septic shock in Thai children from 2015 to 2022. The research found that there were 30,718 pediatric admissions for septic shock during this period, with the highest incidence observed in infants. Mortality rates decreased over the years, but the study highlighted the significant burden that pediatric septic shock places on the healthcare system in Thailand, emphasizing the need for improvements in resources and adherence to clinical guidelines. Addressing disparities in mortality and resource usage across hospital levels was identified as crucial for improving outcomes for pediatric patients with septic shock. [Extracted from the article]

Researchers at Khon Kaen University in Thailand have developed biodegradable antibacterial food packaging using carboxymethyl cellulose, cassava starch, chitosan, and gingerol extract stabilized silver nanoparticles. The packaging showed superior mechanical properties, antibacterial efficacy against both gram-positive and gram-negative bacteria, and biodegradability. This study offers a promising alternative to traditional plastic packaging, addressing the increasing issue of plastic waste. [Extracted from the article]

Researchers from Khon Kaen University conducted a study on Staphylococcus aureus, a significant cause of bacterial infections. The study compared the colony spreading ability of vancomycin-susceptible and non-susceptible S. aureus strains. Results showed that S. aureus with reduced vancomycin susceptibility had a defect in colony spreading ability. This research was funded by the National Science Research and Innovation Fund in Thailand and published in ScienceAsia. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand explored the immediate effects of Thai foot massage on renal blood flow, psychological stress, and heart rate variability in older adults. The study involved 26 healthy older adult volunteers who were randomly assigned to receive either a 15-minute Thai foot massage or 15-minute bed rest. Results showed that Thai foot massage significantly increased renal blood flow and reduced psychological stress, indicating potential benefits for older populations. Further research on a larger scale is recommended to explore these findings in more depth. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand explored the use of laser therapy in managing oral potentially malignant disorders in older adults at the primary care level. The research highlighted the challenges faced by older adults in accessing oral healthcare services and the potential benefits of laser therapy in treating such disorders. The study emphasized the importance of integrating laser techniques into geriatric care and oral cancer screening to improve access to treatment options for older patients. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand evaluated the use of subjective inflation techniques for measuring endotracheal tube cuff pressure in pediatric patients. The study found that these techniques, such as the minimal occluding volume (MOV) and stethoscope-guided methods, did not always achieve the target cuff pressure, leading to risks of overinflation and underinflation. Factors such as age, weight, height, and tube size were associated with inappropriate inflation. The study concluded that subjective inflation techniques may not always be reliable in achieving the desired cuff pressure in pediatric patients. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand focused on the hearing, speech, and language outcomes in school-aged children after cleft palate repair. The research found that children with cleft palate faced challenges such as conductive hearing loss and compensatory articulation disorders. The study highlighted the importance of early intervention to improve hearing and articulation, ultimately supporting academic achievement and long-term quality of life for these children. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand explored the effects of Cannabidiol (CBD) on human Cholangiocarcinoma (CCA) cells. The research found that CBD effectively inhibited CCA cell proliferation, induced cell death, autophagy, and senescence through the PI3K/AKT/mTOR pathway, suggesting a potential therapeutic option for CCA treatment. The study was supported by various research funds and involved in vitro and in vivo experiments to analyze the impact of CBD on CCA cells. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand explored the effects of Cannabidiol (CBD) on human Cholangiocarcinoma (CCA) cells. The research found that CBD effectively inhibited CCA cell proliferation, induced cell death, autophagy, and senescence through the PI3K/AKT/mTOR pathway. These findings suggest that CBD could be a potential therapeutic option for CCA treatment. For more information, the study was published in the Journal of Traditional and Complementary Medicine. [Extracted from the article]

A study conducted by Khon Kaen University in Myanmar aimed to investigate the relationship between hygiene practices and diarrhea prevalence among children under five years old. The research found that children with limited or no access to basic hygiene services were more likely to experience diarrhea. Other factors associated with diarrhea included inadequate handwashing, water collection time, shared toilet usage, hygiene health literacy, house construction, family size, and breastfeeding practices. The study emphasized the importance of handwashing facilities in reducing diarrhea incidence among children. [Extracted from the article]

Researchers at Khon Kaen University in Thailand conducted a study on the deposition and permeation characteristics of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) from cannabis extract gels. The study found that the release of phytocannabinoids from the gels followed Zero-order kinetics, with different permeation rates for CBD and THC. The research concluded that these findings provide valuable insights for selecting appropriate vehicles for cannabis extract topical products. The study was supported by Rangsit University and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand explored the potential relationship between the greater occipital nerve (GON) and the obliquus inferior capitis muscle (OIC) as a cause of occipital neuralgia. The study, which involved anatomical examinations on adult cadavers, found that the GON pierced the OIC in a small percentage of cases, leading to histological changes consistent with nerve compression. The researchers concluded that entrapment of the GON by the OIC could be an underrecognized cause of occipital neuralgia. This peer-reviewed research sheds light on a potential etiology of this condition and provides valuable insights for further study and clinical practice. [Extracted from the article]

A recent study conducted by Khon Kaen University in Thailand analyzed the epidemiology and clinical outcomes of pediatric drowning in the country from 2015 to 2019. The study found that drowning remains a common cause of death among children in Thailand, particularly among males under the age of six. The majority of drownings occurred during the summer season, with April having the highest number of cases. Factors associated with the need for intubation included metabolic acidosis and pulmonary edema, while in-hospital cardiac arrest and drowning-related complications, such as renal failure, were significantly associated with mortality. The study highlights the importance of understanding the risk factors and outcomes of pediatric drowning in order to develop effective prevention strategies. [Extracted from the article]

A recent report from Khon Kaen University in Thailand discusses the case of a female Maine Coon cat with recurrent feline mammary fibroadenomatous hyperplasia (FMFH) during gestation. FMFH is a condition where there is an extensive growth of mammary tissues in response to hormones. The cat was successfully treated with aglepristone during the first occurrence of FMFH, but it recurred during subsequent gestation. The researchers concluded that further discussion is needed regarding the use of cats previously diagnosed with FMFH for breeding purposes. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand has explored the use of well-synthesized carbon dots from the flower of Cassia fistula and its hydrothermally grown heterojunction photocatalyst with zinc oxide (CDs@ZnO-H400) for the photocatalytic degradation of ciprofloxacin and paracetamol. The researchers found that the CDs@ZnO-H400 catalyst effectively removed both medications, with ciprofloxacin showing a maximum photocatalytic efficiency of 99.8% degradation and paracetamol exhibiting a degradation efficiency of 75.1%. The synthesized photocatalyst also demonstrated strong photoactivity even after four usage cycles. This research highlights the potential of using carbon dots and zinc oxide for the removal of pharmaceutical residues in aquatic environments, which can contribute to bacterial resistance and pose a hazard to public health. [Extracted from the article]

Researchers at Khon Kaen University in Thailand have conducted a study on polymeric nanoparticles for drug delivery systems. Using computational molecular dynamics simulations, they found that customizing copolymers with varying ratios of lactic acid to glycolic acid and different lengths of the MPEG chain can improve drug encapsulation efficiency. Increasing the glycolic content of the copolymers resulted in better encapsulation of the drug gemcitabine, suggesting a slow-release profile. This research has the potential to contribute to the development of efficient drug delivery systems using polymeric nanocarriers. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand has investigated the use of sodium caseinate films loaded with fluconazole for the treatment of oral candidiasis. The researchers found that the fluconazole-loaded films demonstrated anticandidal activity and were able to effectively release the drug. The films also showed good stability after three months of storage. This research suggests that fluconazole-loaded sodium caseinate films have potential as a treatment for oral candidiasis. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand explored the potential benefits of kaempferol, a natural flavonoid, in preventing hypertension-induced renal remodeling in rats. The study found that kaempferol treatment alleviated haemodynamic changes associated with hypertension, reduced glomerular hypertrophy and renal tubulointerstitial fibrosis, and inhibited the angiotensin-converting enzyme (ACE) activity and angiotensin II (Ang II) levels in hypertensive rats. Additionally, kaempferol treatment reduced oxidative stress and the expression of proteins associated with renal remodeling. These findings suggest that kaempferol may have a protective effect against renal remodeling in hypertensive individuals. [Extracted from the article]

A study conducted by Khon Kaen University in Thailand examined the incidence of hospital admissions for diabetic ketoacidosis (DKA) in Thai children and adolescents with type 1 diabetes (T1D) from 2015 to 2019. The study found that the annual incidences of T1D and DKA admissions increased over the study period. Recurrent episodes accounted for 52% of DKA admissions, and the highest incidence of DKA admission was observed in individuals aged 13-17 years. Females had a higher risk of DKA hospitalization compared to males, and individuals residing in the Northeast region of Thailand had a higher risk as well. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand investigated the effects of anethum graveolens (dill) extract and its major constituents on hepatoprotective effects in a fatty liver model. The researchers found that the extract and its constituents showed hepatoprotective activities by preventing fatty acid accumulation and restoring the expression of fatty acid synthesis-related genes. The efficacy of the extract was comparable to the standard antilipidemic drug, fenofibrate. The findings suggest that anethum graveolens extract, chlorogenic acid, and ellagic acid could be potential preventive health supplements for fatty liver disease therapy. [Extracted from the article]

Researchers from Khon Kaen University in Thailand have conducted a study to explore the estrogenic activity of Derris scandens, a plant used in traditional Thai medicine for perimenopause and menopause. The study found that certain compounds derived from D. scandens, such as genistein, exhibited estrogenic effects and increased the expression of human estrogen receptors. However, prenylated derivatives of genistein were found to suppress the expression of the human androgen receptor. The researchers concluded that this herbal medicine may be safe for breast cancer patients exposed to estrogen. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand has developed a temporary external fixator (TEF) for mandibular reconstruction. The TEF is a device used to bridge resection defects before secondary mandibular reconstruction surgery. The study used the quality function deployment (QFD) and the theory of inventive problem-solving (TRIZ) to design the TEF, with a focus on safety and adequate operational space. The research also found that reducing the screw size could help reduce hole defects in the mandible. This research has been peer-reviewed and published in Sains Malaysiana. For more information, readers can contact Khon Kaen University. [Extracted from the article]

A recent report from Khon Kaen University in Thailand explores the potential protective effects of Yanang water extract (YWE) against the cytotoxicity caused by methomyl, a hazardous substance used in agricultural production. The study found that YWE had no toxicity against RAW 264.7 macrophage cells, while methomyl significantly reduced cell growth and induced apoptosis and cell cycle arrest. However, when YWE was co-treated with methomyl, it exhibited a protective effect by suppressing the expression of caspase-9 and caspase-3 mRNA levels and altering the protein profile associated with apoptosis and cell cycle arrest. These findings suggest that YWE may mitigate the cytotoxic effects of methomyl by suppressing apoptosis and cell cycle arrest. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand aimed to identify factors associated with the severity of influenza infection in children who were admitted to the hospital after being diagnosed with influenza in the emergency department. The study found that patients with pneumonia and those who required hospitalization or were admitted to the critical care unit consistently exhibited an elevated absolute monocyte count and a reduced lymphocyte-to-monocyte ratio (LMR). The research concluded that an LMR below 2 can be used as a prognostic marker for hospitalization in children with influenza infection. [Extracted from the article]

Researchers from Khon Kaen University in Thailand have developed a new method for monitoring kidney health using a 3D graphene-based sensor and machine learning. The study found that the integration of a graphene electrode with an extreme learning machine (ELM) improved the accuracy of detecting neutrophil gelatinase-associated lipocalin (NGAL), a biomarker for acute kidney injury (AKI). The ELM increased the detection accuracy, precision, sensitivity, specificity, and F1 score for AKI prediction. The research suggests the potential for miniaturizing AI-enhanced sensors for practical applications. [Extracted from the article]

A study conducted at Khon Kaen University in Thailand examined the diagnostic performance of a new IgG4 rapid test for strongyloidiasis, a parasitic disease caused by Strongyloides stercoralis. The researchers compared the new test with traditional diagnostic methods and found that the rapid test had a higher prevalence rate and greater diagnostic sensitivity. The study concluded that the new test is a valuable tool for investigating the epidemiology of strongyloidiasis. This research has been peer-reviewed and published in the American Journal of Tropical Medicine and Hygiene. [Extracted from the article]

A recent study conducted by Khon Kaen University in Thailand explored the factors impacting the survival outcome and consequences in children with reactivation/refractory Langerhans-Cell Histiocytosis (LCH). The study included 47 patients, with 25 experiencing disease reactivation and 22 having refractory LCH. The most common site of reactivation/refractory was the bone, and 42.6% of patients developed late sequelae. The 5-year overall survival rate was 76.1%, and lung reactivation was identified as an independent risk factor associated with survival. The study suggests that the outcomes for pediatric patients with reactivation and refractory LCH in Thailand are desirable, with minimal mortality, although late sequelae may occur. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand has developed a new method for detecting Listeria monocytogenes, a type of bacteria that can cause foodborne illnesses. The researchers used a lateral flow strip (LFS) that utilized a specific antibody attached to gold nanoparticles to detect the bacteria. The LFS showed high sensitivity and specificity, with no false-positive or false-negative results observed. This new method has the potential to be used as a point-of-care test for rapid and accurate detection of Listeria monocytogenes in both clinical samples and contaminated food. [Extracted from the article]

A recent report from Khon Kaen University in Thailand examines the trends in incidence and survival rates of childhood cancers in Khon Kaen, Thailand from 2000 to 2019. The study analyzed data from the population-based Khon Kaen Cancer Registry and found that the incidence of childhood cancers has increased over time. However, the survival rates have also improved and are comparable to those of other countries with similar financial status. The researchers attribute these positive outcomes to the implementation of national health policies and adherence to national treatment guidelines. [Extracted from the article]

A study conducted by Khon Kaen University in Thailand compared the effectiveness and safety of subcutaneous and intravenous fentanyl for managing labor pain. The study involved 226 women who were randomized to receive either intravenous or subcutaneous fentanyl. Both routes of administration significantly reduced labor pain, and there was no difference in pain reduction between the two groups. Maternal satisfaction was high regardless of the route of administration, and no serious adverse effects were observed in either the mothers or the neonates. This research provides valuable insights into pain management during labor and highlights the safety and effectiveness of fentanyl. [Extracted from the article]

A recent report from Khon Kaen University in Thailand discusses research findings on the enhancement of isoflavonoid production and release in Pueraria candollei cell suspension culture using elicitors for improving pharmacological activities. Pueraria candollei is used as an herbal medicine to alleviate postmenopausal symptoms. The researchers found that employing 2-hydroxypropyl-beta-cyclodextrin (HPBCD) and cellulase as elicitors increased the production of isoflavonoids and deoxymiroestrol in the cell suspension culture. The study concluded that these techniques can be strategically used to improve the quality and productivity of P. candollei cells as a source of functional ingredients. [Extracted from the article]

A recent study conducted by Khon Kaen University in Thailand examined the management of library services in university libraries in Thailand and Vietnam during different phases of the pandemic. The study found that prior to the pandemic, academic libraries focused on integrating e-resources and library services into the university learning management system. During the pandemic, efforts were made to negotiate access to database providers and improve digital platforms for library services. Post-pandemic, there was an emphasis on assessing and recovering library services, as well as formulating strategic plans for the future. The study provides valuable insights for library administrators and librarians in addressing challenges and meeting the diverse needs of users. [Extracted from the article]

A recent study conducted by researchers at Khon Kaen University in Thailand explored the use of red yeast rice (RYR) and optimal fermentation periods to improve the quality of Esan fermented fish sausage (EFFS). The study found that incorporating 0.35% or 0.7% RYR increased the redness of the sausage, resulting in improved sensory color, overall acceptability, and preference ranking. However, RYR levels did not affect other quality parameters such as microbial analyses, acidity, weight loss, or texture. The study also found that the sensory parameters of the sausage improved by day 2 of fermentation, remained stable until day 4, and then deteriorated by day 6. This research provides valuable insights for the food science industry and may contribute to the development of visually appealing and high-quality EFFS. [Extracted from the article]

A recent study conducted at Khon Kaen University in Thailand examined the fecal metabolome of children with Hirschsprung disease (HD) after a pull-through operation. The researchers used nuclear magnetic resonance (NMR) spectroscopy to analyze fecal samples from both HD patients and healthy children under 5 years old. The study found significant differences in the levels of certain metabolites between the two groups, particularly in amino acid metabolism pathways. These findings suggest that there are alterations in host-microbial co-metabolism in children with HD after the pull-through operation. [Extracted from the article]