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32 results on '"Keleman, Krystyna"'

2. Genetics of intellectual disability in consanguineous families

Author

Hu, Hao, Kahrizi, Kimia, Musante, Luciana, Fattahi, Zohreh, Herwig, Ralf, Hosseini, Masoumeh, Oppitz, Cornelia, Abedini, Seyedeh Sedigheh, Suckow, Vanessa, Larti, Farzaneh, Beheshtian, Maryam, Lipkowitz, Bettina, Akhtarkhavari, Tara, Mehvari, Sepideh, Otto, Sabine, Mohseni, Marzieh, Arzhangi, Sanaz, Jamali, Payman, Mojahedi, Faezeh, Taghdiri, Maryam, Papari, Elaheh, Soltani Banavandi, Mohammad Javad, Akbari, Saeide, Tonekaboni, Seyed Hassan, Dehghani, Hossein, Ebrahimpour, Mohammad Reza, Bader, Ingrid, Davarnia, Behzad, Cohen, Monika, Khodaei, Hossein, Albrecht, Beate, Azimi, Sarah, Zirn, Birgit, Bastami, Milad, Wieczorek, Dagmar, Bahrami, Gholamreza, Keleman, Krystyna, Vahid, Leila Nouri, Tzschach, Andreas, Gärtner, Jutta, Gillessen-Kaesbach, Gabriele, Varaghchi, Jamileh Rezazadeh, Timmermann, Bernd, Pourfatemi, Fatemeh, Jankhah, Aria, Chen, Wei, Nikuei, Pooneh, Kalscheuer, Vera M., Oladnabi, Morteza, Wienker, Thomas F., Ropers, Hans-Hilger, and Najmabadi, Hossein

Published
2019
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6. Dopamine neurons modulate pheromone responses in Drosophila courtship learning

Author

Keleman, Krystyna, Vrontou, Eleftheria, Kruttner, Sebastian, Yu, Jai Y., Kurtovic-Kozaric, Amina, and Dickson, Barry J.

Subjects
Neurons -- Genetic aspects, Dopamine -- Properties, Drosophila -- Genetic aspects, Courtship of animals -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Learning through trial-and-error interactions allows animals to adapt innate behavioural 'rules of thumb' to the local environment, improving their prospects for survival and reproduction. Naive Drosophila melanogaster males, for example, [...]

Published
2012

7. Systematic genetic analysis of muscle morphogenesis and function in Drosophila

Author

Schnorrer, Frank, Schonbauer, Cornelia, Langer, Christoph C.H., Dietzl, Georg, Novatchkova, Maria, Schernhuber, Katharina, Fellner, Michaela, Azaryan, Anna, Radolf, Martin, Stark, Alexander, Keleman, Krystyna, and Dickson, Barry J.

Subjects
Embryonic development -- Genetic aspects -- Research, Genes -- Physiological aspects -- Research, Drosophila -- Analysis -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Systematic genetic approaches have provided deep insight into the molecular and cellular mechanisms that operate in simple unicellular organisms. For multicellular organisms, however, the pleiotropy of gene function has largely restricted such approaches to the study of early embryogenesis. With the availability of genome-wide transgenic RNA interference (RNAi) libraries in Drosophila (1,2), it is now possible to perform a systematic genetic dissection of any cell or tissue type at any stage of the lifespan. Here we apply these methods to define the genetic basis for formation and function of the Drosophila muscle. We identify a role in muscle for 2,785 genes, many of which we assign to specific functions in the organization of muscles, myofibrils or sarcomeres. Many of these genes are phylogenetically conserved, including genes implicated in mammalian sarcomere organization and human muscle diseases., Muscle biology is an attractive target for analysis by genome-wide transgenic RNAi. The basic cell and developmental biology of muscles is largely conserved from insects to mammals (3-6), and their [...]

Published
2010
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9. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

Author

Dietzl, Georg, Chen, Doris, Schnorrer, Frank, Su, Kuan-Chung, Barinova, Yulia, Fellner, Michaela, Gasser, Beate, Kinsey, Kaolin, Oppel, Silvia, Scheiblauer, Susanne, Couto, Africa, Marra, Vincent, Keleman, Krystyna, and Dickson, Barry J.

Subjects
Gene mutations -- Research -- Genetic aspects, Gene expression -- Research -- Genetic aspects, Drosophila -- Research -- Genetic aspects, Phenotype -- Research -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Research, Genetic aspects
Abstract

Author(s): Georg Dietzl [1, 2]; Doris Chen [1]; Frank Schnorrer [2]; Kuan-Chung Su [1]; Yulia Barinova [1]; Michaela Fellner [1, 2]; Beate Gasser [1]; Kaolin Kinsey [1, 2]; Silvia Oppel [...]

Published
2007
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10. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Author

Lundstrom, Annika, Aspenstrom, Pontus, Steneberg, Par, Hemphala, Johanna, Dickson, Barry J., Keleman, Krystyna, Samakovlis, Christos, Falileeva, Ludmilla, Englund, Camilla, and Gallio, Marco

Subjects
Axons -- Research, Axons -- Genetic aspects, Epithelial cells -- Research, Epithelial cells -- Genetic aspects, Biological sciences
Abstract

The functional analysis of vilse, a drosophila gene required for Robo repulsion in epithelial cells and axons is described. The results and the genetic interaction experiments with robo, vilse, and rac mutants suggest a mechanism whereby Robo repulsion is mediated by the localized inactivation of Rac through Vilse.

Published
2004

11. Comm sorts Robo to control axon guidance at the Drosophila midline

Author

Keleman, Krystyna, Rajagopalan, Srikanth, Cleppien, Diana, Teis, David, Paiha, Karin, Huber, Lukas A., Technau, Gerhard M., and Dickson, Barry J.

Subjects
Central nervous system -- Physiological aspects, Developmental neurology -- Physiological aspects, Axons -- Growth, Growth -- Regulation, Biological sciences
Abstract

Results suggest that comm gene functions as an autonomous switch and determines if and when an axon crosses the midline in Drosophila. Further, comm encoded protein Comm facilitates axon growth across the midline by scavenging Robo protein from new membrane vesicles.

Published
2002

12. Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

Author

Newsome, Timothy P., Schmidt, Susanne, Dietzl, Georg, Keleman, Krystyna, Asling, Bengt, Debant, Anne, and Dickson, Barry J.

Subjects
Cytochemistry -- Research, Photoreceptors -- Genetic aspects, Drosophila -- Genetic aspects, Axons -- Genetic aspects, Cellular signal transduction -- Research, Protein kinases -- Physiological aspects, Biological sciences
Abstract

Trio has been found to combine with the SH2-SH3 adaptor Dock to regulate p21-activated kinase (Pak) activity in Drosophila photoreceptor axon pathfinding. The guanine nucleotide exchange factor (GEF) Trio has been identified and found to be another required part of photorecpetor axon guidance.

Published
2000

16. Drosophila Courtship Conditioning As a Measure of Learning and Memory

Author

Koemans, Tom S., Oppitz, Cornelia, Donders, Rogier A. T., van Bokhoven, Hans, Schenck, Annette, Keleman, Krystyna, and Kramer, Jamie M.

Subjects
Male, learning, short-term memory, fungi, Courtship, long-term memory, Drosophila melanogaster, Issue 124, courtship conditioning, Memory, Animals, Humans, Drosophila, Female, Neuroscience
Abstract

Many insights into the molecular mechanisms underlying learning and memory have been elucidated through the use of simple behavioral assays in model organisms such as the fruit fly, Drosophila melanogaster. Drosophila is useful for understanding the basic neurobiology underlying cognitive deficits resulting from mutations in genes associated with human cognitive disorders, such as intellectual disability (ID) and autism. This work describes a methodology for testing learning and memory using a classic paradigm in Drosophila known as courtship conditioning. Male flies court females using a distinct pattern of easily recognizable behaviors. Premated females are not receptive to mating and will reject the male's copulation attempts. In response to this rejection, male flies reduce their courtship behavior. This learned reduction in courtship behavior is measured over time, serving as an indicator of learning and memory. The basic numerical output of this assay is the courtship index (CI), which is defined as the percentage of time that a male spends courting during a 10 min interval. The learning index (LI) is the relative reduction of CI in flies that have been exposed to a premated female compared to naïve flies with no previous social encounters. For the statistical comparison of LIs between genotypes, a randomization test with bootstrapping is used. To illustrate how the assay can be used to address the role of a gene relating to learning and memory, the pan-neuronal knockdown of Dihydroxyacetone phosphate acyltransferase (Dhap-at) was characterized here. The human ortholog of Dhap-at, glyceronephosphate O-acyltransferase (GNPT), is involved in rhizomelic chondrodysplasia punctata type 2, an autosomal-recessive syndrome characterized by severe ID. Using the courtship conditioning assay, it was determined that Dhap-at is required for long-term memory, but not for short-term memory. This result serves as a basis for further investigation of the underlying molecular mechanisms.

Published
2017

18. Genetics of intellectual disability in consanguineous families

Author

Hu, Hao, primary, Kahrizi, Kimia, additional, Musante, Luciana, additional, Fattahi, Zohreh, additional, Herwig, Ralf, additional, Hosseini, Masoumeh, additional, Oppitz, Cornelia, additional, Abedini, Seyedeh Sedigheh, additional, Suckow, Vanessa, additional, Larti, Farzaneh, additional, Beheshtian, Maryam, additional, Lipkowitz, Bettina, additional, Akhtarkhavari, Tara, additional, Mehvari, Sepideh, additional, Otto, Sabine, additional, Mohseni, Marzieh, additional, Arzhangi, Sanaz, additional, Jamali, Payman, additional, Mojahedi, Faezeh, additional, Taghdiri, Maryam, additional, Papari, Elaheh, additional, Soltani Banavandi, Mohammad Javad, additional, Akbari, Saeide, additional, Tonekaboni, Seyed Hassan, additional, Dehghani, Hossein, additional, Ebrahimpour, Mohammad Reza, additional, Bader, Ingrid, additional, Davarnia, Behzad, additional, Cohen, Monika, additional, Khodaei, Hossein, additional, Albrecht, Beate, additional, Azimi, Sarah, additional, Zirn, Birgit, additional, Bastami, Milad, additional, Wieczorek, Dagmar, additional, Bahrami, Gholamreza, additional, Keleman, Krystyna, additional, Vahid, Leila Nouri, additional, Tzschach, Andreas, additional, Gärtner, Jutta, additional, Gillessen-Kaesbach, Gabriele, additional, Varaghchi, Jamileh Rezazadeh, additional, Timmermann, Bernd, additional, Pourfatemi, Fatemeh, additional, Jankhah, Aria, additional, Chen, Wei, additional, Nikuei, Pooneh, additional, Kalscheuer, Vera M., additional, Oladnabi, Morteza, additional, Wienker, Thomas F., additional, Ropers, Hans-Hilger, additional, and Najmabadi, Hossein, additional

Published
2018
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22. Function of the Drosophila CPEB protein Orb2 in long-term courtship memory

Author

Keleman, Krystyna, Kruettner, Sebastian, Alenius, Mattias, Dickson, Barry J., Keleman, Krystyna, Kruettner, Sebastian, Alenius, Mattias, and Dickson, Barry J.

Abstract

Both long-term behavioral memory and synaptic plasticity require protein synthesis, some of which may occur locally at specific synapses. Cytoplasmic polyadenylation element-binding (CPEB) proteins are thought to contribute to the local protein synthesis that underlies long-term changes in synaptic efficacy, but a role has not been established for them in the formation of long-term behavioral memory. We found that the Drosophila melanogaster CPEB protein Orb2 is acutely required for long-term conditioning of male courtship behavior. Deletion of the N-terminal glutamine-rich region of Orb2 resulted in flies that were impaired in their ability to form long-term, but not short-term, memory. Memory was restored by expressing Orb2 selectively in fruitless (fru)positive c neurons of the mushroom bodies and by providing Orb2 function in mushroom bodies only during and shortly after training. Our data thus demonstrate that a CPEB protein is important in long-term memory and map the molecular, spatial and temporal requirements for its function in memory formation.

Published
2007
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24. Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a

Author

Kramer, Jamie M., primary, Kochinke, Korinna, additional, Oortveld, Merel A. W., additional, Marks, Hendrik, additional, Kramer, Daniela, additional, de Jong, Eiko K., additional, Asztalos, Zoltan, additional, Westwood, J. Timothy, additional, Stunnenberg, Hendrik G., additional, Sokolowski, Marla B., additional, Keleman, Krystyna, additional, Zhou, Huiqing, additional, van Bokhoven, Hans, additional, and Schenck, Annette, additional

Published
2011
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28. Netrins

Author

Dickson, Barry J, primary and Keleman, Krystyna, additional

Published
2002
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29. Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth

Author

Wittwer, Franz, Straten, Alexandra van der, Keleman, Krystyna, Dickson, Barry J., and Hafen, Ernst

Abstract

Members of the AF4/FMR2 family of nuclear proteins are involved in human diseases such as acute lymphoblastic leukemia and mental retardation. Here we report the identification and characterization of the Drosophila lilliputian (lilli) gene, which encodes a nuclear protein related to mammalian AF4 and FMR2. Mutations in lilli suppress excessive neuronal differentiation in response to a constitutively active form of Raf in the eye. In the wild type, Lilli has a partially redundant function in the Ras/MAPK pathway in differentiation but it is essential for normal growth. Loss of Lilli function causes an autonomous reduction in cell size and partially suppresses the increased growth associated with loss of PTEN function. These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth.

Published
2001
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30. brakeless is required for lamina targeting of R1-R6 axons in the Drosophila visual system

Author

Senti, Kirsten-Andr, Keleman, Krystyna, Eisenhaber, Frank, and Dickson, Barry J.

Abstract

Photoreceptors in the Drosophila eye project their axons retinotopically to targets in the optic lobe of the brain. The axons of photoreceptor cells R1-R6 terminate in the first optic ganglion, the lamina, while R7 and R8 axons project through the lamina to terminate in distinct layers of the second ganglion, the medulla. Here we report the identification of the gene brakeless (bks) and show that its function is required in the developing eye specifically for the lamina targeting of R1-R6 axons. In mosaic animals lacking bks function in the eye, R1-R6 axons project through the lamina to terminate in the medulla. Other aspects of visual system development appear completely normal: photoreceptor and lamina cell fates are correctly specified, R7 axons correctly target the medulla, and both correctly targeted R7 axons and mistargeted R1-R6 axons maintain their retinotopic order with respect to both anteroposterior and dorsoventral axes. bks encodes two unusually hydrophilic nuclear protein isoforms, one of which contains a putative C2H2 zinc finger domain. Transgenic expression of either Bks isoform is sufficient to restore the lamina targeting of R1-R6 axons in bks mosaics, but not to retarget R7 or R8 axons to the lamina. These data demonstrate the existence of a lamina-specific targeting mechanism for R1-R6 axons in the Drosophila visual system, and provide the first entry point in the molecular characterization of this process.

Published
2000
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31. Epigenetic regulation of learning and memory

Author

Kramer, Jamie M., Kochinke, Korinna, Oortveld, Merel A. W., Marks, Hendrik, Kramer, Daniela, Jong, Eiko K., Stunnenberg, Henk, Asztalos, Zoltan, Sokolowski, Marla B., Keleman, Krystyna, Zhou, Jo, J.H.L.M. (Hans) van Bokhoven, and Schenck, Annette

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