Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Authors :: Lundstrom, Annika
Aspenstrom, Pontus
Steneberg, Par
Hemphala, Johanna
Dickson, Barry J.
Keleman, Krystyna
Samakovlis, Christos
Falileeva, Ludmilla
Englund, Camilla
Gallio, Marco
Source :: Genes & Development. Sept 1, 2004, Vol. 18 Issue 17, p2161, 11 p.
Publication Year :: 2004
Abstract: The functional analysis of vilse, a drosophila gene required for Robo repulsion in epithelial cells and axons is described. The results and the genetic interaction experiments with robo, vilse, and rac mutants suggest a mechanism whereby Robo repulsion is mediated by the localized inactivation of Rac through Vilse.

Subjects :: Axons -- Research
Axons -- Genetic aspects
Epithelial cells -- Research
Epithelial cells -- Genetic aspects
Biological sciences

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