95 results on '"Ke MY"'
Search Results
2. Gastric myoelectrical activity in different stages of diabetes mellitus
- Author
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Lan, Yu, primary, Ke, My, additional, and Wang, Zf, additional
- Published
- 2000
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3. Correlation of epigastric fullness with the proximal and distal gastric volume by ultrasonography in functional dyspepsia
- Author
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Guo, Jq, primary, Ke, My, additional, Jiang, Yx, additional, and Zhang, Sq, additional
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- 2000
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4. The relationship between GERD and OSAS and effects of anti-reflux therapy
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Xiao, GH, primary, Wang, ZF, additional, Ke, MY, additional, and Huang, XZ, additional
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- 1998
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5. Cisapride improves postprandial symptoms and gastric myoelectric activity in functional dyspepsia
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Chen, JDZ, primary, Ke, MY, additional, Lin, XM, additional, Wang, ZF, additional, Zhang, M, additional, Mellow, M, additional, and Orr, WC, additional
- Published
- 1998
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6. The role of midgastric transverse band in the regulation of intragastric distribution and gastric emptying in patients with type II diabetes mellitus
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Gu, CM, primary, Ke, MY, additional, Zhu, ZH, additional, and Li, F, additional
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- 1998
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7. The motor function of the pylori in patients with achalasia — A preliminary report
- Author
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Ke, MY, primary, Lan, Y, additional, and Wang, ZF, additional
- Published
- 1994
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8. Sex-determining region Y gene promotes liver fibrosis and accounts for sexual dimorphism in its pathophysiology.
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Wu XN, Wang MZ, Zhang N, Zhang W, Dong J, Ke MY, Xiang JX, Ma F, Xue F, Hou JJ, Ma ZJ, Wang FM, Liu XM, Wu R, Pawlik TM, Ye K, Yu J, Zhang XF, and Lyu Y
- Subjects
- Animals, Female, Male, Mice, Carbon Tetrachloride toxicity, Carbon Tetrachloride adverse effects, Cholestasis genetics, Cholestasis metabolism, Cholestasis physiopathology, Disease Models, Animal, Mice, Knockout, Receptor, Platelet-Derived Growth Factor alpha genetics, Receptor, Platelet-Derived Growth Factor alpha metabolism, Sex Characteristics, Hepatic Stellate Cells metabolism, Hepatocytes metabolism, Liver Cirrhosis chemically induced, Liver Cirrhosis genetics, Liver Cirrhosis metabolism, Sex-Determining Region Y Protein genetics, Sex-Determining Region Y Protein metabolism
- Abstract
Background & Aims: Men are more prone to develop and die from liver fibrosis than women. In this study, we aim to investigate how sex-determining region Y gene (SRY) in hepatocytes promotes liver fibrosis., Methods: Hepatocyte-specific Sry knock-in (KI), Sry knockout (KO), and Sry KI with platelet-derived growth factor receptor α (Pdgfrα) KO mice were generated. Liver fibrosis was induced in mice by bile duct ligation for 2 weeks or carbon tetrachloride treatment for 6 weeks. In addition, primary hepatocytes, hepatic stellate cells (HSCs), and immortalized cell lines were used for in vitro studies and mechanistic investigation., Results: Compared to females, the severity of toxin- or cholestasis-induced liver fibrosis is similarly increased in castrated and uncastrated male mice. Among all Y chromosome-encoded genes, SRY was the most significantly upregulated and consistently increased gene in fibrotic/cirrhotic livers in male patients and in mouse models. Sry KI mice developed exacerbated liver fibrosis, whereas Sry KO mice had alleviated liver fibrosis, compared to age- and sex-matched control mice after bile duct ligation or administration of carbon tetrachloride. Mechanistically, both our in vivo and in vitro studies illustrated that SRY in hepatocytes can transcriptionally regulate Pdgfrα expression, and promote HMGB1 (high mobility group box 1) release and subsequent HSC activation. Pdgfrα KO or treatment with the SRY inhibitor DAX1 in Sry KI mice abolished SRY-induced HMGB1 secretion and liver fibrosis., Conclusions: SRY is a strong pro-fibrotic factor and accounts for the sex disparity observed in liver fibrosis, suggesting its critical role as a potentially sex-specific therapeutic target for prevention and treatment of the disease., Impact and Implication: We identified that a male-specific gene, sex-determining region Y gene (SRY), is a strong pro-fibrotic gene that accounts for the sex disparity observed in liver fibrosis. As such, SRY might be an appropriate target for surveillance and treatment of liver fibrosis in a sex-specific manner. Additionally, SRY might be a key player in the sexual dimorphism observed in hepatic pathophysiology more generally., (Copyright © 2024 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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9. Value of needle confocal laser microendoscopy combined with endobronchial ultrasound bronchoscopy in the diagnosis of hilar and mediastinal lymph node lesions.
- Author
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Zuo CY, Xue KY, Wu XM, Lin LC, Luo BQ, Chen ZD, Lin YL, Tian XQ, and Ke MY
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- Humans, Mediastinum diagnostic imaging, Mediastinum pathology, Lymph Nodes diagnostic imaging, Lymph Nodes pathology, Lung pathology, Sensitivity and Specificity, Retrospective Studies, Bronchoscopy methods, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology
- Abstract
Endobronchial ultrasound bronchoscopy (EBUS) and needle confocal laser endomicroscopy (nCLE) are techniques for screening benign and malignant lesions of the hilar and mediastinal lymph node (HMLN). This study investigated the diagnostic potential of EBUS, nCLE, and combined EBUS and nCLE in HMLN lesions. We recruited 107 patients with HMLN lesions who were examined by EBUS and nCLE. A pathological examination was performed, and the diagnostic potential of EBUS, nCLE, and combined EBUS-nCLE approach was analyzed according to the results. Among the 107 cases of HMLN lesions, 43 cases were benign and 64 cases were malignant on pathological examination, 41 cases were benign and 66 cases were malignant on EBUS examination; 42 cases were benign and 65 cases were malignant on nCLE examination; 43 cases were benign and 64 cases were malignant on combined EBUS-nCLE examination. The combination approach had 93.8% sensitivity, 90.7% specificity, and 0.922 area under the curve, which was higher than those of EBUS (84.4%, 72.1%, and 0.782, respectively) and nCLE diagnosis (90.6%, 83.7%, and 0.872, respectively). The combination approach had a higher positive predictive value (0.908), negative predictive value (0.881), and positive likelihood ratio (10.09) than that of EBUS (0.813, 0.721, and 3.03, respectively) and nCLE (0.892, 0.857, and 5.56, respectively), whereas, the negative likelihood ratio was lower than that for EBUS (0.22) and nCLE (0.11). No serious complications occurred in patients with HMLN lesions. To summarize, the diagnostic efficacy of nCLE was better than EBUS. The EBUS-nCLE combination is a suitable approach for diagnosing HMLN lesions., (© 2023 The Authors. The Kaohsiung Journal of Medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung Medical University.)
- Published
- 2023
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10. The m 6 A reader YTHDF1 attenuates fulminant hepatitis via MFG-E8 translation in an m 6 A dependent manner.
- Author
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Ke MY, Fang Y, Cai H, Lu JW, Yang L, Wang Y, Wu RQ, Zhang XF, Lv Y, and Dong J
- Subjects
- Animals, Mice, Apoptosis genetics, Lipopolysaccharides, RNA genetics, Massive Hepatic Necrosis, RNA-Binding Proteins metabolism
- Abstract
Background and Aims: N6-methyladenosine (m
6 A) is the most common post-transcriptional modification of RNA in eukaryotes, which has been demonstrated to play important roles in various biological processes. However, its roles in fulminant hepatitis remain largely unknown. In the current study, YTHDF1 expression was found to be significantly downregulated in the livers among patients, as well as murine models with fulminant hepatitis versus normal controls. Thus, we hypothesized that YTHDF1 protects against fulminant hepatitis and investigated the underlying molecular mechanisms. Methods: Fulminant hepatitis was induced by D-GalN/LPS in conventional YTHDF1 knockout (YTHDF1-/- ) mice, hepatocyte-specific YTHDF1 overexpression (AAV8- YTHDF1) mice, and corresponding control mice. Primary hepatocytes were cultured and subjected to LPS insult in vitro . Hepatic histology, cell death, oxidative stress and mitochondrial function were examined to assess liver damage. The molecular mechanisms of YTHDF1 function were explored using multi-omics analysis. Results: Ablation of YTHDF1 exacerbated hepatic apoptosis and reactive oxygen species (ROS) production and increased the number of aberrant mitochondria, while YTHDF1 overexpression resulted in the opposite effects. Multiomics analysis identified MFG-E8 as the direct target of YTHDF1. YTHDF1 augmented the translation of MFG-E8 in an m6 A-dependent manner without effect on its mRNA expression, thereby restoring mitochondrial function. Additionally, administration of MFG-E8 almost completely reversed the YTHDF1 deficiency-mediated exacerbation of liver injury. Conclusions: The current study suggested that the m6 A reader YTHDF1 alleviates cell death, enhances antioxidant capacity and restores mitochondrial function in fulminant hepatitis by promoting MFG-E8 protein translation in an m6 A-dependent manner., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)- Published
- 2023
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11. The influence of low-level viremia on CD4+ cell count in human immunodeficiency virus-infected patients.
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Lee CT, Chen HP, Lin HH, Ke MY, and Wu PF
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- Humans, CD4 Lymphocyte Count, Viremia complications, Viremia drug therapy, Viral Load, HIV, HIV Infections drug therapy, HIV Infections complications
- Abstract
Background: Following initiation of combined antiretroviral therapy, the majority of human immunodeficiency virus-infected patients experience immune reconstitution indicated by virologic suppression and an increase in peripheral CD4+ T-cell counts. Some patients may suffer from low-level viremia, which was reported to be significantly associated with acquired immunodeficiency syndrome cases, virologic failure, and death. We aimed to further investigate the influence of low-level viremia on CD4+ T-cell count., Methods: In our study, we included human immunodeficiency virus-seropositive patients on combined antiretroviral therapy, for at least 6 months, who received at least one assessment of human immunodeficiency virus plasma viral load and CD4+ cell count every 6 months, from January 2009 to January 2019. The copy-year viremia was determined by calculating the area under the curve of the plasma human immunodeficiency virus viral load., Results: When comparing patients with a mean CD4+ cell count <200 cells/μL, there was no significant difference between patients with a mean viral load <1000 copies/mL and patients with a mean viral load ≥1000 copies/mL (p = 0.219). Among those with a mean viral load <1000 copies/mL, a higher proportion of patients had a mean CD4+ cell count ≥500 cells/µL (p < 0.001). The mean CD4+ cell count of patients with copy-years viremia (log10) <4 (577.7, interquartile range 429.2-736.7) was significantly higher than that of patients with copy-years viremia (log10) ≥4 (443.3, interquartile range 319.0-558.4) (p < 0.001). In multivariate logistic regression analysis, we observed that malignancy without history, lower copy-years viremia, and high nadir CD4+ cell count were independent predictors of mean CD4+ cell count ≥500 cells/µL., Conclusion: Human immunodeficiency virus-infected patients with a history of malignancy, high copy-year viremia, and lower nadir CD4+ cell counts should be monitored carefully in clinical settings., Competing Interests: Conflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article., (Copyright © 2022, the Chinese Medical Association.)
- Published
- 2022
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12. Are bowel symptoms and psychosocial features different in irritable bowel syndrome patients with abdominal discomfort compared to abdominal pain?
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Fang XC, Fan WJ, Drossman DD, Han SM, and Ke MY
- Subjects
- Abdominal Pain complications, Abdominal Pain etiology, Humans, Intestines, Quality of Life, Surveys and Questionnaires, Irritable Bowel Syndrome complications, Irritable Bowel Syndrome diagnosis
- Abstract
Background: The Rome IV criteria eliminated abdominal discomfort for irritable bowel syndrome (IBS), which was previously included in Rome III. There are questions as to whether IBS patients with abdominal discomfort (seen in Rome III but not Rome IV) are different from those with abdominal pain (Rome IV)., Aim: To compare bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain & discomfort., Methods: We studied IBS patients meeting Rome III criteria. We administered the IBS symptom questionnaire, psychological status, and IBS quality of life. Patients were classified according to the predominant abdominal symptom associated with defecation into an only pain group, only discomfort group, and pain & discomfort group. We compared bowel symptoms, extraintestinal symptoms, IBS quality of life, psychological status and healthcare-seeking behaviors, and efficacy among the three groups. Finally, we tested risk factors for symptom reporting in IBS patients., Results: Of the 367 Rome III IBS patients enrolled, 33.8% (124 cases) failed to meet Rome IV criteria for an IBS diagnosis. There were no meaningful differences between the pain group ( n = 233) and the discomfort group ( n = 83) for the following: (1) Frequency of defecatory abdominal pain or discomfort; (2) Bowel habits; (3) Coexisting extragastrointestinal pain; (4) Comorbid anxiety and depression; and (5) IBS quality of life scores except more patients in the discomfort group reported mild symptom than the pain group (22.9% vs 9.0%). There is a significant tendency for patients to report their defecatory and non-defecatory abdominal symptom as pain alone, or discomfort alone, or pain & discomfort (all P < 0.001)., Conclusion: IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain. IBS symptoms manifesting abdominal pain or discomfort may primarily be due to different sensation and reporting experience., Competing Interests: Conflict-of-interest statement: There are no conflicts of interest to report., (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2022
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13. Comparison of operation time, efficacy and safety between through-the-scope stent and over-the-while stent in malignant central airway obstruction: a multi-center randomized control trial.
- Author
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Zeng DX, Cheng ZZ, Lv XD, Chen CS, Wang JW, Browning R, Wang KP, Huang JA, Dutau H, Kheir F, Ke MY, and Jiang JH
- Abstract
Background: Self-expandable metallic (SEM) airway stents are an important approach to treating malignant central airway obstruction (CAO). Standard over-the-while (OTW) stent needs the guidance of a guide-wire. It should be implanted under flouroscopy or the guidance of bronchoscope visualization. In this study, we evaluated the operation time and safety between OTW stent and a novel through-the-scope (TTS) SEM airway stent., Methods: In this multi-center, randomized, parallel-group superiority study, malignant CAO patients were enrolled randomly assigned (2:1) to the TTS stent implantation group (TTS group) or the standard OTW stent group (OTW group) in six sites across China. The entire process of all surgical procedures was recorded by video. Primary endpoint was the operation time of the airway stent implantation and secondary endpoint was the success rate of the stent implantation as well as its efficacy and safety., Results: From May 15, 2017, to December 30, 2018, 148 patients were enrolled from the six sites. We analyzed 134 patients (including 91 patients from the TTS group and 43 patients from the OTW group) according to the per-protocol set. There were no significant differences in the ages, genders, underlying diseases, and stenosis sites between the two groups. The operation time in the TTS group was significantly shorter than that in the OTW group (104±68 vs. 252±111 seconds, P<0.001). Compared to the OTW group, the efficacy of stent implantation (97.80% vs. 90.70%, P=0.093) and rate of first-time successful stent implantation (78.02% vs. 74.42%, P=0.668) were higher in the TTS group, but did not reach statistically significance. The rates of granulation (28.57% vs. 41.86%, P=0.128) and restenosis (15.38% vs. 30.23%, P=0.064) in the TTS group were slightly lower as compared with the OTW group without achieving statistical significance., Conclusions: The TTS stent implantation procedure time was significantly shorter than that of the OTW airway stent with similar efficacy and complications, which might reduce the risk and flexibility of stent implantation., Trial Registration: Chinese Clinical Trial Registry ChiCTR-IOR-17011431., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-22-565/coif). HD received Royalties on the Dutau Novatech rigid bronchoscope and is the consultant for Novatech. The other authors have no conflicts of interest to declare., (2022 Translational Lung Cancer Research. All rights reserved.)
- Published
- 2022
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14. SRY is a Key Mediator of Sexual Dimorphism in Hepatic Ischemia/Reperfusion Injury.
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Dong J, Ke MY, Wu XN, Ding HF, Zhang LN, Ma F, Liu XM, Wang B, Liu JL, Lu SY, Wu R, Pawlik TM, Lyu Y, and Zhang XF
- Subjects
- Animals, Apoptosis, Female, Glycogen Synthase Kinase 3 beta metabolism, Ischemia, Liver pathology, Male, Mice, Sex Characteristics, beta Catenin, Liver Diseases metabolism, Reperfusion Injury, Sex-Determining Region Y Protein metabolism
- Abstract
Objectives: To identify the role and mechanism of a male specific gene, SRY, in I/R-induced hepatic injury., Background: Males are more vulnerable to I/R injury than females. However, the mechanism of these sex-based differences remains poorly defined., Methods: Clinicopathologic data of patients who underwent hepatic resection were identified from an international multi-institutional database. Liver specific SRY TG mice were generated, and subjected to I/R insult with their littermate WT controls in vivo. In vitro experiments were performed by treating primary hepatocytes from TG and WT mice with hypoxia/reoxygen-ation stimulation., Results: Clinical data showed that postoperative aminotransferase level, incidence of overall morbidity and liver failure were markedly higher among 1267 male versus 508 female patients who underwent hepatic resection. SRY was dramatically upregulated during hepatic I/R injury. Overexpression of SRY in male TG mice and ectopic expression of SRY in female TG mice exacerbated liver I/R injury compared with WTs as manifested by increased inflammatory reaction, oxidative stress and cell death in vivo and in vitro. Mechanistically, SRY interacts with Glycogen synthase kinase-3β (GSK-3β) and β-catenin, and promotes phosphorylation and degradation of β-catenin, leading to suppression of the downstream FOXOs, and activation of NF-κBand TLR4 signaling. Furthermore, activation of β-catenin almost completely reversed the SRYoverexpression-mediated exacerbation of hepatic I/R damage., Conclusions: SRY is a novel hepatic I/R mediator that promotes hepatic inflammatory reaction, oxidative stress and cell necrosis via inhibiting Wnt/β-catenin signaling, which accounts for the sex-based disparity in hepatic I/R injuries., Competing Interests: The authors report no conflicts of interest., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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15. [The innovation and exploration of silicone stent in clinical practice].
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Ke MY and Wu XM
- Subjects
- Silicones, Stents
- Published
- 2021
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16. Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study.
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Tey KY, Gan J, Foo V, Tan B, Ke MY, Schmetterer L, Mehta JS, and Ang M
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- Animals, Anterior Eye Segment blood supply, Burns, Chemical diagnostic imaging, Eye Injuries diagnostic imaging, Male, Models, Animal, Pilot Projects, Prospective Studies, Rabbits, Angiography methods, Anterior Eye Segment diagnostic imaging, Tomography, Optical Coherence methods
- Abstract
To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea limbus into 4 quadrants. Chemical injury grade was induced based on extent of limbal injury (0 to 360 degrees) and all eyes underwent serial slit-lamp with AS-OCTA imaging up to one month. Main outcome measure was changes in AS-OCTA vessel density (VD) comparing injured and control cornea limbal quadrants within 24 h and at one month. AS-OCTA was able to detect differences in limbal VD reduction comparing injured (3.3 ± 2.4%) and control quadrants (7.6 ± 2.3%; p < 0.001) within 24 h of ocular chemical injury. We also observed that AS-OCTA VD reduction was highly correlated with the number of quadrants injured (r = - 0.89; p < 0.001; 95% CI - 5.65 to - 1.87). Corneal vascularization was detected by AS-OCTA in injured compared to control quadrants (10.1 ± 4.3% vs 7.0 ± 1.2%; p = 0.025) at 1 month. Our animal pilot study suggests that AS-OCTA was able to detect limbal vessel disruption from various severities of acute chemical insult, and in the future, could potentially serve as an adjunct in providing objective grading of acute ocular chemical injury once validated in a clinical trial., (© 2021. The Author(s).)
- Published
- 2021
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17. Liver fibrosis promotes immune escape in hepatocellular carcinoma via GOLM1-mediated PD-L1 upregulation.
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Ke MY, Xu T, Fang Y, Ye YP, Li ZJ, Ren FG, Lu SY, Zhang XF, Wu RQ, Lv Y, and Dong J
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- Animals, B7-H1 Antigen biosynthesis, Carcinoma, Hepatocellular pathology, Cell Line, Tumor, ErbB Receptors metabolism, Humans, Liver Cirrhosis pathology, Liver Neoplasms pathology, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Proto-Oncogene Proteins c-akt metabolism, STAT3 Transcription Factor metabolism, Tumor Escape, Tumor Microenvironment, Up-Regulation, B7-H1 Antigen immunology, Carcinoma, Hepatocellular immunology, Liver Cirrhosis immunology, Liver Neoplasms immunology, Membrane Proteins immunology
- Abstract
Immune checkpoint blockade is considered a breakthrough in cancer treatment. However, with the low response rates and therapeutic resistance of patients with hepatocellular carcinoma (HCC), the challenges facing the application of this treatment are tremendous. Liver fibrosis is a key driver of tumor immune escape, the underlying mechanism has never been clarified. This study sought to explore the role of liver fibrosis in regulating tumor-infiltrating lymphocytes (TILs) and inducing tumor immunosuppression. Ninety-nine fixed HCC tissue samples were used to analyze the association between liver fibrosis and immune escape using immunohistochemistry. In HCC patients, low FIB-4 values and high CD8
+ T cell infiltration were correlated with prolonged survival. Elevated expression of immune checkpoints and attenuated antitumor immunity were observed in CCl4 -induced mice liver fibrosis models and human fibrotic livers compared to control group. GOLM1 levels were increased in livers of patients with fibrosis and mice in response to CCl4 -induced liver fibrosis. CD8+ T cell infiltrations were significantly decreased and PD-L1 expression was significantly increased in tumor tissues from hepatocyte-specific GOLM1 transgenic mice (Alb/GOLM1 mice) inducing chemical carcinogenesis compared to their corresponding control WT mice. GOLM1 induced PD-L1 expression via EGFR pathway activation. EGFR inhibitors, especially together with anti-PD-L1 therapy, improved the efficacy of immunotherapy in HCC. These findings illustrate the importance of liver fibrosis-induced immunosuppression as a tumor-promoting mechanism. GOLM1, which is highly upregulated in the fibrotic liver, regulates tumor microenvironmental immune escape via the EGFR/PD-L1 signaling pathway. EGFR blockade may bolster the efficacy of immune checkpoint inhibitors for HCC treatment., (Copyright © 2021 Elsevier B.V. All rights reserved.)- Published
- 2021
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18. Construction of CTC-ALK gene fusion detection system based on the multi-site magnetic separation in lung cancer and its clinical verification.
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Ma AP, Guo WX, Gao DH, Ke MY, Luo Q, and Liu Q
- Subjects
- Gene Fusion, Humans, Liposomes, Magnetics, Receptor Protein-Tyrosine Kinases genetics, Anaplastic Lymphoma Kinase genetics, Carcinoma, Non-Small-Cell Lung diagnosis, Carcinoma, Non-Small-Cell Lung genetics, Lung Neoplasms diagnosis, Lung Neoplasms genetics, Oncogene Proteins, Fusion genetics
- Abstract
Detected in a variety of solid tumors, including lung cancer, the EML4-ALK fusion gene plays an important role in promoting the occurrence and development of cancer. The existing detection methods for EML4-ALK fusion gene are all targeted at surgical or post-sampling tumor tissues, which cannot achieve early detection and real-time monitoring; therefore, a minimally invasive ALK gene fusion detection system is explored and constructed. Vimentin, EpCAM, and EGFR antibodies were grafted, respectively, to prepare multi-site immunoliposome magnetic beads, so as to capture CTC in blood for RT-PCR detection, and then the feasibility of this method was verified by detecting the positive rate of the EML4-ALK fusion gene and clinical information in combination with WB and IHC. The prepared multi-site immunoliposome magnetic beads showed high specificity and stability, and the average proliferation rate and capture rate of cells were 95% and 85%, respectively. In clinical blood samples, the CTC level of the grade I (G1) patients before the operation was lower than grade 2 (G2), and that of grade II (G2) was significantly lower than grade III (G3), but the difference was not significant after the operation. The RT-PCR results of CTC and the RT-PCR, WB, and IHC results of tissues were highly consistent in the fusion gene detection, and the positive rate of ALK gene fusion in 60 lung cancer patients was 31.67% and 28.33% before and after the operation, mostly EML4-ALK (V3) gene fusion. The CTC-ALK gene fusion detection system constructed successfully could avoid the problem of difficult sampling and post-sampling complications, and truly achieve the minimally invasive biopsy, so it was of important clinical significance for the diagnosis and efficacy evaluation of lung.
- Published
- 2020
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19. [Covered airway stent loaded with (125)I seeds for tracheal adenoid cystic carcinoma: a clinical observation of 8 cases].
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Luo BQ, Ke MY, Zeng JL, Huang R, Lin LC, Wu XM, and Yong YZ
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- Airway Obstruction etiology, Carcinoma, Adenoid Cystic complications, Humans, Neoplasm Recurrence, Local, Retrospective Studies, Tracheal Neoplasms complications, Treatment Outcome, Carcinoma, Adenoid Cystic pathology, Carcinoma, Adenoid Cystic surgery, Iodine Radioisotopes, Stents, Tracheal Neoplasms pathology, Tracheal Neoplasms surgery, Tracheal Stenosis therapy
- Abstract
Objective: To explore the efficacy and safety of the covered airway stent loaded with (125)I seeds for the treatment of tracheal adenoid cystic carcinoma (TACC). Methods: We retrospectively reviewed the clinical data from 8 patients with TACC who had received placement of the covered stent loaded with (125)I seeds between December 2014 and July 2017 in the endoscopic center of the Second Affiliated Hospital of Xiamen Medical College. We compared the difference in the dyspnea index, the diameter of the airway lumen, and the lesion surrounding the airway wall before and after treatment. The complications were also recorded during follow-up. Results: Eight patients underwent successful placement of a total of 11 radioactive stents (2 straight-type stents, 2 L-shape stents, and 7 Y-shape stents, all loaded a total of 243 radioactive particles). Displacement of stents took place within 2 weeks in 2 patients, who were managed with re-stenting and fixation. No further displacement occurred during follow-up. The median time to stent removal was 2.9(interquartile range: 2.3,3.0) months. After stent placement, the dyspnea index was significantly decreased compared with pre-treatment level (mean: 0.1 vs. 3.4, t= 8.881, P< 0.001). Bronchoscopic re-assessment showed that the residual tumor within the airway was detected in only one patient and that the tumor completely disappeared in the remaining 7 patients. Treatment with stents loaded with radioactive particles yielded smooth and pale airway mucosa with formation of partial scar formation. Chest computed tomography re-assessment demonstrated significantly larger luminal diameter than that before treatment (mean: 13.1 mm vs. 3.3 mm, t= -7.839, P< 0.001). The airway wall thickness was notably reduced after treatment (mean: 4.3 mm vs. 14.4 mm, t= 7.620, P< 0.001). The lesions surrounding the airway wall completely disappeared in 7 patients and decreased for more than 50% in a single patient. The median duration of follow-up was 28.0(interquartile range: 24.8,31.5) months. Recurrence of tumor was documented in a single case within 2 years. Six patients did not experience recurrence within the 2-year follow-up period. No death or severe complications were recorded during follow-up. Conclusion: The (125)I radioactive stent is effective for dilating the stenotic airway and ameliorating the symptoms, and thus might be an effective and safe method for the treatment of TACC. Further studies that explore the efficacy of stents loaded with (125)I particles are needed.
- Published
- 2020
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20. [Psychometric Evaluation of the Union Physio-Psycho-Social Assessment Questionnaire].
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Duan YP, Wei J, Hong X, Cao JY, Shi LL, Zhao XH, Ke MY, Zhu YJ, Li SW, Jiang J, and Shan GL
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- Factor Analysis, Statistical, Humans, Reproducibility of Results, Psychological Tests standards, Psychometrics, Surveys and Questionnaires
- Abstract
Objective To validate the Union Physio-Psycho-Social Assessment Questionnaire(UPPSAQ-70)and test its validity and reliability.Methods From April,2013 to July,2018,patients were asked to finish the computer evaluation of UPPSAQ-70 and Symptom Checklist 90(SCL-90)in Peking Union Medical College Hospital(PUMCH).Confirmatory factor analysis(CFA)was conducted on the SPSS 17.0,and the number of fixed factors was 8 factors and 3 factors.Amos 23.0 was used to verify the original 8-factor model,8-factor revision model,3-factor model,3-factor revision model,and single-factor model.Each factor of SCL-90 was used as the calibration standard to calculate the correlation coefficient between factors.The retest reliability was tested by the outpatients in PUMCH in July,2018.Results Exploratory factor analysis indicated that the 8-factor revised model included:depression,anxiety and fatigue,sleep,physical discomfort,sexual function,happiness and satisfaction,hypochondria,and social anxiety.The 3 factors revised model included that:psychological,physiological and social dimension.Confirmatory factor analysis indicated that the 8-factor modified model was superior to the 3-factor model and the single-factor model: χ
2 =10 410.4, df =1862,RMSEA=0.07,CFI=0.753,and NFI=0.715.With SCL-90 as the standard criteria,except the low correlation coefficient between emotional scale and depression( r =0.600)and anxiety( r =0.520),the correlation coefficients of other symptoms were below 0.5.The chronbach's α between each factor and total score of UPPSAQ-70 was between 0.823 and 0.904,and the Chronbach's α coefficient of the whole scale was between 0.954 and 0.956 after each item was deleted.The retest reliability of the scale of 32 participants Chronbach's α was 0.847.Each item of the scale measured between one week was significantly correlated( P <0.05). Conclusion UPPSAQ-70 is a good scale for evaluating overall health status and is especially feasible in general hospitals.- Published
- 2019
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21. Serum GP73 predicts posthepatectomy outcomes in patients with hepatocellular carcinoma.
- Author
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Ke MY, Wu XN, Zhang Y, Wang S, Lv Y, and Dong J
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- Biomarkers, Tumor blood, Female, Humans, Liver pathology, Liver Cirrhosis blood, Liver Cirrhosis pathology, Male, Middle Aged, Multivariate Analysis, Postoperative Complications blood, Postoperative Complications etiology, ROC Curve, Risk Factors, Treatment Outcome, Carcinoma, Hepatocellular blood, Carcinoma, Hepatocellular surgery, Hepatectomy adverse effects, Liver Neoplasms blood, Liver Neoplasms surgery, Membrane Proteins blood
- Abstract
Background and Aims: Serum GP73 is a useful biomarker in assessing hepatic fibrosis degree. The aim of this study was to evaluate the predictive value of serum GP73 level for posthepatectomy short-term outcomes in hepatocellular carcinoma (HCC) patients., Methods: A total of 280 patients undergoing liver resection for HCC between October 2015 and April 2018 were included in this study. Detailed preoperative clinicopathological data were collected and GP73 levels in serum obtained the day before hepatectomy were examined. Receiver operating characteristic (ROC) analysis was used to calculate the optimal cutoff of GP73, and independent risk factors for postoperative outcomes was assessed by logistic regression model., Results: The mean GP73 level in patients was 111.8 ± 153.3 ng/mL. Serum GP73 levels were correlated with the METAVIR fibrosis score. Overall complications occurred in 145 patients and major complications developed in 29 patients. ROC analysis demonstrated that the predictive power of serum GP73 for postoperative outcomes was greater than the Child-Pugh score, ALBI score, FIB-4 index and APRI score. The optimal value of serum GP73 to predict overall complications and major complications was 80.9 and 79.2 respectively. Serum GP73 levels were independent factors affecting the incidence of overall complications (odds ratio [OR], 3.996; 95% CI 2.152-7.421; P < 0.001) and major complications (OR, 4.970; 95% CI 1.654-14.934; P = 0.004) by multivariate analysis., Conclusion: Serum GP73 is a useful tool to stratify HCC patients and to predict short-term outcomes after hepatectomy.
- Published
- 2019
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22. Gamma-glutamyl transpeptidase to platelet ratio predicts short-term outcomes in hepatocellular carcinoma patients undergoing minor liver resection.
- Author
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Ke MY, Zhang M, Su Q, Wei S, Zhang J, Wang Y, Wu R, and Lv Y
- Subjects
- Adult, Aged, Aspartate Aminotransferases, Biomarkers blood, Carcinoma, Hepatocellular blood, Carcinoma, Hepatocellular complications, Female, Humans, Liver Cirrhosis blood, Liver Cirrhosis complications, Liver Neoplasms blood, Liver Neoplasms complications, Male, Middle Aged, Multivariate Analysis, Platelet Count, Postoperative Complications diagnosis, ROC Curve, Retrospective Studies, Risk Factors, Blood Platelets metabolism, Carcinoma, Hepatocellular surgery, Hepatectomy, Liver Cirrhosis diagnosis, Liver Neoplasms surgery, Postoperative Complications etiology, gamma-Glutamyltransferase blood
- Abstract
Background: There is a strong correlation between liver fibrosis and postoperative morbidity after hepatectomy in hepatocellular carcinoma (HCC) patients. The aim of this study was to evaluate which noninvasive fibrosis index (gamma-glutamyl transpeptidase to platelet ratio [GPR], aspartate aminotransferase to platelet ratio index, fibrosis-4 index, or Forns index) was best able to predict complications in patients undergoing hepatectomy for HCC., Materials and Methods: This retrospective analysis included 275 patients who underwent hepatectomy for HCC from January 2008 to December 2012. Postoperative mortality was defined as death within 90 d after surgery. Complications were grouped into seven grades on the basis of the modified Clavien classification, and major postoperative complications were defined as grade 3 or above. The influence of noninvasive fibrosis indices on postoperative outcomes was assessed by receiver operating characteristic analysis. The primary outcomes were overall complications and major complications, estimated by univariate and multivariate analysis., Results: Patients with HCC undergoing anatomical liver resection in the authors' department were evaluated for this study. Finally, 275 patients who underwent minor liver resection (≤2 liver segments) were included. Of these, 231 (84%) were male. The multivariate analysis indicated that the GPR index was not only independently associated with overall complications (hazard ratio, 2.692; 95% confidence interval [CI], 1.626-4.250; P < 0.001) but also independently predictive of major complications (hazard ratio, 1.143; 95% CI, 1.046-1.249; P = 0.03). The areas under the receiver operating characteristic curve for predicting overall complications and major complications for the GPR index were 0.704 (95% CI, 0.643-0.765; P < 0.001) and 0.752 (95% CI, 0.638-0.865; P < 0.001), respectively., Conclusions: The data suggested that the GPR index could be a promising predictor of overall postoperative complications and major complications after minor hepatectomy for HCC., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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23. Effect of high-fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects.
- Author
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Fan WJ, Hou YT, Sun XH, Li XQ, Wang ZF, Guo M, Zhu LM, Wang N, Yu K, Li JN, Ke MY, and Fang XC
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Esophageal pH Monitoring methods, Esophagogastric Junction physiopathology, Female, Gastric Acidity Determination, Humans, Hydrogen-Ion Concentration, Male, Manometry methods, Middle Aged, Young Adult, Diet, High-Fat, Functional Food, Gastroesophageal Reflux diet therapy, Gastroesophageal Reflux metabolism
- Abstract
Objectives: To investigate the effects of different test meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects and to demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH., Methods: We enrolled patients with reflux esophagitis (RE; n = 15), nonerosive reflux disease (NERD; n = 12) and healthy subjects (n = 10). Four pH electrodes were used to monitor the pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26 hours. Isocaloric and isovolumetric high-fat, standard, and functional meals were supplied randomly to the participants. The EAE and gastric acidity of each meal in fasting and postprandial states were compared., Results: High-fat meals significantly increased postprandial EAE in patients with RE and NERD. EAE was higher after a high-fat meal than after a standard or functional food meals at the fourth hour postprandially in patients with RE (P < 0.05). Patients with NERD reported fewer symptoms after a functional food meal than after high-fat and standard meals (0 [interquartile range {IQR} 0-1] vs 1 [IQR 0-2] vs 3 [IQR 1-4], P = 0.014). Compared with high-fat and standard meals, functional food meal significantly decreased gastric acidity in patients with RE. EAE was significantly related to gastric acidity in patients with RE., Conclusions: High-fat meals increased EAE in patients with RE and NERD. Functional food could serve as adjuvant therapy in GERD patients. EAE was related to gastric acidity in RE patients., (© 2018 The Authors. Journal of Digestive Diseases published by Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.)
- Published
- 2018
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24. Illness Perception of Patients with Functional Gastrointestinal Disorders.
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Xiong NN, Wei J, Ke MY, Hong X, Li T, Zhu LM, Sha Y, Jiang J, and Fischer F
- Abstract
Objective: To investigate the illness perception characteristics of Chinese patients with functional gastrointestinal disorders (FGID), and the mediating role between symptoms, psychopathology, and clinical outcomes., Methods: Six illness groups from four outpatient departments of a general hospital in China were recruited, including the FGID patient group. The modified and validated Chinese version of the illness perception questionnaire-revised was utilized, which contained three sections: symptom identity, illness representation, and causes. The 12-item short-form health survey was utilized to reflect the physical and mental health-related quality of life (HRQoL). The Toronto alexithymia scale was used to measure the severity of alexithymia. Additional behavioral outcome about the frequency of doctor visits in the past 12 months was measured. Pathway analyses with multiple-group comparisons were conducted to test the mediating role of illness perception., Results: Overall, 600 patients were recruited. The illness perceptions of FGID patients were characterized as with broad non-gastrointestinal symptoms (6.8 ± 4.2), a negative illness representation (more chronic course, worse consequences, lower personal and treatment control, lower illness coherence, and heavier emotional distress), and high numbers of psychological and culture-specific attributions. Fit indices of the three hypothesized path models (for physical and mental HRQoL and doctor-visit frequency, respectively) supported the mediating role of illness perceptions. For example, the severity of alexithymia and non-gastrointestinal symptoms had significant negative effect on mental quality of life through both direct (standardized effect: -0.085 and -0.233) and indirect (standardized effect: -0.045 and -0.231) influence via subscales of consequences, emotional representation, and psychological and risk factor attributions. Multi-group confirmatory factor analysis showed similar psychometric properties for FGID patients and the other disease group., Conclusion: The management of FGID patients should take into consideration dysfunctional illness perceptions, non-gastrointestinal symptoms, and emotion regulation.
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- 2018
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25. The PAC-SYM questionnaire for chronic constipation: defining the minimal important difference.
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Yiannakou Y, Tack J, Piessevaux H, Dubois D, Quigley EMM, Ke MY, Da Silva S, Joseph A, and Kerstens R
- Subjects
- Chronic Disease, Constipation drug therapy, Double-Blind Method, Humans, ROC Curve, Reproducibility of Results, Constipation physiopathology, Randomized Controlled Trials as Topic methods, Surveys and Questionnaires standards
- Abstract
Background: The Patient Assessment of Constipation-Symptoms (PAC-SYM) questionnaire is frequently used in clinical trials of constipation. However, the threshold for reduction in total PAC-SYM score used to define a clinical response on this 0-4 point scale has not undergone formal appraisal, and its relationship with clinical benefit as perceived by patients has not been defined., Aim: To determine the minimal important difference in PAC-SYM score, and the optimum cut-off value for defining responders., Methods: The minimal important difference was estimated using data from six international phase 3/4, double-blind, randomised controlled trials of prucalopride in patients with chronic constipation (NCT01147926, NCT01424228, NCT01116206, NCT00485940, NCT00483886, NCT00488137), with anchor- and distribution-based approaches. Five appropriate patient-reported outcomes were selected as anchors. In addition, receiver operating characteristics (ROC) curve analyses were used to investigate responder discrimination for each anchor., Results: Data from 2884 patients were included. Minimal important difference estimates ranged from -0.52 to -0.63 across the five anchors. Estimates were not affected by study location but were consistently lower for rectal symptoms than for abdominal and stool symptoms. Distribution-based estimates were considerably lower than anchor-based estimates. ROC curve analyses showed optimum cut-off scores for discriminating responders to be similar to anchor-based minimal important difference estimates., Conclusions: Anchor-based methods gave consistent results for the minimal important difference, at approximately -0.6, and this value was close to the ROC-determined optimal cut-off scores for responder discrimination. This value could be considered in clinical practice. A slightly more conservative threshold (eg -0.75) could be used in clinical trials to reduce the placebo response rate., (© 2017 Shire International GMBH. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)
- Published
- 2017
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26. Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.
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Liu C, Ren YF, Dong J, Ke MY, Ma F, Monga SPS, Wu R, Lv Y, and Zhang XF
- Subjects
- Animals, Carcinoma, Hepatocellular chemically induced, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular pathology, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic pathology, Cyclin D1 metabolism, Diethylnitrosamine, Female, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Humans, Liver Neoplasms chemically induced, Liver Neoplasms genetics, Liver Neoplasms pathology, Male, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Phosphatidylinositol 3-Kinase metabolism, Proto-Oncogene Proteins c-akt metabolism, Proto-Oncogene Proteins c-myc metabolism, Receptor, Platelet-Derived Growth Factor alpha metabolism, SOX9 Transcription Factor metabolism, Sex Factors, Sex-Determining Region Y Protein genetics, Signal Transduction, Time Factors, Tumor Microenvironment, Up-Regulation, Carcinoma, Hepatocellular metabolism, Cell Transformation, Neoplastic metabolism, Health Status Disparities, Liver Neoplasms metabolism, Sex-Determining Region Y Protein metabolism
- Abstract
Sex affects the risk, treatment responses and outcome of many types of cancers. The mechanism of gender disparity in development of hepatocellular carcinoma (HCC) remains obscure. Sex-determining region on Y chromosome (SRY) was overexpressed in approximate 84% male patient HCC. Moreover, we are the first to generate a liver-specific transgenic (TG) murine model with overexpression of the male specific gene SRY. Subject to a single intraperitoneal injection N-nitrosodiethylamine (DEN) at day 14, TG and wildtype (WT) mice of both genders were sacrificed at different time points (6-13.5 months). Overexpression of SRY in male TG and ectopic expression of SRY in female TG livers promoted DEN-induced hepatocarcinogenesis compared to age- and sex-matched WT. This accelerated tumorigenesis in TG of both genders was a consequence of increased injury and inflammation, fibrosis, and compensatory enhancement in hepatocytes proliferation secondary to activation of downstream targets Sox9 and platelet-derived growth factor receptor α (PDGFRα)/phosphoinositide 3-kinase (PI3K)/Akt and c-myc/CyclinD1. In conclusion, activation of SRY and its downstream Sox9 and PDGFRα pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of HCC., (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Published
- 2017
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27. Efficacy of the Dumon™ Stent in the Treatment of Airway Gastric Fistula: A Case Series Involving 16 Patients.
- Author
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Ke MY, Huang R, Lin LC, Zeng JL, and Wu XM
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Bronchoscopy methods, Gastric Fistula surgery, Stents
- Published
- 2017
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28. The motility of esophageal sphincters during liquid and solid bolus swallows: a multicenter normative value study of high-resolution manometry in China.
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Xiang XL, Wang A, Tu L, Ke MY, Yang YS, Jiang B, Lin L, Dai N, Zhang SS, Tao L, Xu H, Liang XM, Fang XC, Xia ZW, Wang X, Wu JN, Wang MF, Zhang HJ, Fang YF, Shen C, Wang J, Peng LH, Li WY, Wang ZF, Wang K, Liu N, and Hou XH
- Subjects
- Adult, China epidemiology, Female, Humans, Male, Middle Aged, Deglutition physiology, Drinking physiology, Eating physiology, Esophageal Sphincter, Lower physiology, Gastrointestinal Motility physiology, Manometry methods
- Abstract
Background: It is gradually accepted that solid bolus swallow needs to be added to the procedure of manometry. The motility differences in the upper esophageal sphincter (UES) and lower esophageal sphincter (LES) were not well described. Sierra Scientific Instruments solid-state high-resolution manometry (HRM) system, the most popular HRM system in China, lacks the Chinese normative values for both liquid and solid bolus swallow parameters., Methods: The esophageal HRM data of 88 healthy volunteers were analyzed. The parameters of both sphincters in resting stage were summarized and those during solid and liquid swallows were compared., Key Results: Normative HRM values of sphincter parameters in solid and liquid bolus swallows in China were established. The UES residual pressure of solid bolus swallows was lower than that of liquid bolus (0.3±5.5 mm Hg vs 4.8±5.9 mm Hg, P=.000). The time parameters of UES relaxation between two types of bolus swallows were similar. In solid bolus swallows, the intrabolus pressure (IBP) (13.8±5.1 mm Hg vs 10.9±5.7 mm Hg, P=.000) and LES relaxation time (11.0±2.1 seconds vs 8.7±1.3 seconds, P=.000) were higher. The 4-second integrated relaxation pressure between both bolus swallows was similar., Conclusions & Inferences: The function of the UES and LES between solid and liquid bolus swallows is different. Chinese HRM parameters are different from the Chicago Classification (http://www.chictr.org.cn, Number ChiCTR-EOC-15007147)., (© 2016 John Wiley & Sons Ltd.)
- Published
- 2017
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29. The FIB-4 score predicts postoperative short-term outcomes of hepatocellular carcinoma fulfilling the milan criteria.
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Dong J, Xu XH, Ke MY, Xiang JX, Liu WY, Liu XM, Wang B, Zhang XF, and Lv Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Hepatectomy, Humans, Male, Middle Aged, Postoperative Complications epidemiology, Predictive Value of Tests, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Carcinoma, Hepatocellular surgery, Liver Cirrhosis complications, Liver Neoplasms surgery
- Abstract
Background: The fibrosis score 4 (FIB-4) score is a useful tool to determine the degree of hepatic fibrosis. Liver fibrosis and cirrhosis are well-known predictors of postoperative complications after hepatectomy. This study examined the impact of FIB-4 on postoperative short-term outcomes of patients with hepatocellular carcinoma (HCC)., Methods: Three hundred and fifty patients undergoing hepatectomy for HCC between 2008 and 2013 were enrolled. The receiver operating characteristic (ROC) curve analysis was performed to determine the cutoff value of the FIB-4. Univariate and multivariate analysis was performed to identify the risk factors. The correlation of the preoperative FIB-4 value with clinicopathological parameters was examined., Results: Postoperative complications were observed in 202 (57.7%) patients. The optimal cutoff value of the FIB-4 was set at 2.88 and 3.85 for postoperative complications and intraoperative blood loss respectively. It was also an independent prognostic factor for postoperative complications (hazard ratio [HR], 1.202; 95% CI, 1.076-1.344; P = 0.001) and intraoperative blood loss (HR, 1.196; 95% CI, 1.091-1.343; P < 0.001) by multivariate analysis. The FIB-4 was significantly correlated with age, liver function, coagulation function, blood loss, intraoperative blood transfusion (all P < 0.05)., Conclusion: Preoperative FIB-4 is a useful index to predict postoperative outcomes in patients with HCC. The FIB-4 should be assessed routinely for hepatocellular carcinoma patients., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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30. [Summary of the 4th Integrative Medical Forum on Gastrointestinal Functions and Dynamic Diseases].
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Wei W, Yang YS, and Ke MY
- Subjects
- Gastrointestinal Diseases physiopathology, Humans, Congresses as Topic, Gastrointestinal Diseases therapy, Integrative Medicine
- Published
- 2015
31. Diagnosis of functional constipation: agreement between Rome III and Rome II criteria and evaluation for the practicality.
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Xin HW, Fang XC, Zhu LM, Xu T, Fei GJ, Wang ZF, Chang M, Wang LY, Sun XH, and Ke MY
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- Adolescent, Adult, Aged, Aged, 80 and over, Chronic Disease, Constipation etiology, Constipation physiopathology, Defecation physiology, Diagnostic Techniques, Digestive System standards, Female, Humans, Male, Middle Aged, Reproducibility of Results, Surveys and Questionnaires, Young Adult, Constipation diagnosis
- Abstract
Objective: To investigate the agreement between Rome III and Rome II criteria for diagnosing functional constipation (FC) and to evaluate the accuracy of each constipation symptom for FC diagnosis., Methods: Patients with chronic constipation underwent rigorous biochemical and endoscopic/imaging tests to exclude organic and metabolic diseases. The questionnaires including general information, constipation symptoms, and the most troublesome constipation symptoms were completed in a face-to-face survey. The accuracy of constipation symptoms for FC diagnosis was examined using the likelihood ratio., Results: Among 184 patients (43 males and 141 females) with chronic constipation, 166 (90.2%) met Rome II criteria and 174 (94.6%) met Rome III criteria for FC, while 166 met both criteria. There was a good diagnostic agreement between the two sets of criteria, with a kappa value of 0.69 and the overall agreement rate was 95.7% (P < 0.001). Based on Rome III criteria, the most accurate symptom for FC diagnosis was sensation of anorectal blockage, followed by straining during defecation and infrequent bowel movements. The most troublesome symptoms reported by patients were lumpy or hard stools, straining during defecation, sensation of incomplete evacuation. More patients indicated that 'the symptoms in the past 3 months' was better than 'those within the past one year' to reflect their constipation (36.7% vs 6.0%, P < 0.001)., Conclusions: There is good agreement between Rome III and Rome II criteria for FC diagnosis. Rome III criteria are more practical than Rome II criteria for Chinese patients., (© 2014 The Authors. Journal of Digestive Diseases published by Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.)
- Published
- 2014
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32. The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes.
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Yu K, Ke MY, Li WH, Zhang SQ, and Fang XC
- Subjects
- Aged, Beverages, Biomarkers blood, Cross-Over Studies, Dietary Fiber administration & dosage, Female, Humans, Male, Middle Aged, Prospective Studies, Stomach diagnostic imaging, Ultrasonography, Blood Glucose, Diabetes Mellitus, Type 2 blood, Dietary Fiber pharmacology, Gastric Emptying physiology, Insulin blood, Postprandial Period physiology
- Abstract
Dietary fibre plays an important role in controlling postprandial glycemic and insulin response in diabetic patients. The intake of dietary fibre has been shown to delay the gastric emptying in healthy subjects. The relationship between gastric emptying and postprandial blood glucose in diabetic patients with fibre-load liquids needs to be investigated. To investigate the impact of soluble dietary fibre (SDF) on gastric emptying, postprandial glycemic and insulin response in patients with type 2 diabetes. 30 patients with type 2 diabetes (DM) and 10 healthy subjects (HS) matched for gender and age were randomized to receive SDF-free liquid (500 mL, 500 Kcal) and isoenergetic SDF liquid (oat β-glucan 7.5 g, 500 mL, 500 Kcal) on two separate days based on a cross-over with 6-day wash-out period. Gastric emptying was monitored by ultrasonography at intervals of 30 min for 2 hours. Fasting and postprandial blood was collected at intervals of 30-60 min for 180 min to determine plasma glucose and insulin. Proximal gastric emptying was delayed by SDF-treatment both in DM (p=0.001) and HS (p=0.037). SDF resulted in less output volume in the distal stomach in DM (p<0.05). SDF decreased postprandial glucose (p=0.001) and insulin (p=0.001) in DM subjects. Postprandial glucose (r=-0.547, p=0.047) and insulin (r=-0.566, p=0.004) were negatively correlated with distal emptying of SDF in DM subjects. Distal gastric emptying was delayed significantly in DM subjects with HbA1c levels ≥6.5% (p=0.021) or with complications (p=0.011) by SDF, respectively. SDF improved postprandial glycaemia which was related to slowing of gastric emptying.
- Published
- 2014
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33. [Therapeutic mechanism of diaphragm training at different periods in patients with gastroesophageal reflux disease].
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Ding ZL, Wang ZF, Sun XH, and Ke MY
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Esophagogastric Junction physiopathology, Female, Humans, Male, Middle Aged, Postprandial Period, Young Adult, Diaphragm physiopathology, Gastroesophageal Reflux physiopathology, Gastroesophageal Reflux rehabilitation
- Abstract
Objective: To explore the effects of postprandial diaphragm training (DT) on esophageal acid exposure, esophageal motility and proximal gastric volume at different postprandial periods in patients with gastroesophageal reflux disease (GERD)., Methods: Thirty GERD patients and 9 healthy subjects (HS) with matched demographic characteristics were enrolled from June 2005 to June 2006 at Peking Union Medical College Hospital. Esophageal manometry with a Dent sleeve catheter and simultaneous esophageal pH monitoring were recorded in a 30-min fasting period and a 120-min postprandial period. The GERD patients were divided into 3 groups: 9 patients received diaphragm training at 1(st) hour after meal (group DT1 h) and another 10 at 2(nd) hour after meal (group DT2 h) whereas no diaphragm training after meal in 11 (group NDT). Ultrasonic imaging of proximal gastric volume was undertaken at 0, 30, 60, 90 and 120 min after meal., Results: (1) The percentage time with pH<4 in group DT1 h was lower than that in group NDT in the 120-min postprandial period (0.2% (0-4.1%), 6.6% (2.2%-18.2%), P < 0.05) and no significant difference of esophageal acid exposure was observed between groups DT2 h and NDT (3.7% (0.1%-17.8%), 6.6% (2.2%-18.2%), P > 0.05) . (2) Esophagogastric junction (EGJ) and crural diaphragm pressures at the 1(st) hour after meal in group DT1 h were both significantly higher than those in group NDT during diaphragm training ((44.4 ± 8.1) vs(16.2 ± 4.5) mm Hg, (38.2 ± 4.2) vs (9.8 ± 4.5) mm Hg, 1 mm Hg = 0.133 kPa, both P < 0.05). EGJ and crural diaphragm pressures at the 2(nd) hour after meal in group DT2 h were significantly higher than those in group N-DT during diaphragm training ((53.2 ± 7.5) vs (14.0 ± 3.7) mm Hg, (48.2 ± 6.3) vs (8.9 ± 2.7) mm Hg, both P < 0.05). There was no change of lower esophageal sphincter pressure (all P > 0.05). (3) After test meal, the groups DT1 h, DT2 h and N-DT had similar proximal stomach volume (all P > 0.05)., Conclusions: Diaphragm training at the 1(st) hour after meal might reduce the 120-min postprandial esophageal acid exposure in GERD patients. The reduction in esophageal acid exposure may result from enhanced antireflux barrier of EGJ function. Therefore postprandial diaphragm training provides a new approach to conservative treatment of GERD.
- Published
- 2013
34. Temperature can influence gastric accommodation and sensitivity in functional dyspepsia with epigastric pain syndrome.
- Author
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Wang RF, Wang ZF, Ke MY, Fang XC, Sun XH, Zhu LM, and Zhang J
- Subjects
- Adult, Case-Control Studies, Compliance, Drinking, Female, Humans, Male, Middle Aged, Pressure, Cold Temperature, Dyspepsia physiopathology, Stomach physiopathology
- Abstract
Background: Functional dyspepsia-epigastric pain syndrome (FD-EPS) is characterized pathophysiologically by visceral hypersensitivity, but the effect of the temperature stimulation on gastric function has been seldom studied., Aim: The purpose of this study was to investigate the effects of liquid nutrients at different temperatures on the gastric accommodation, sensitivity, and gastric-wall compliance of healthy subjects (HS) and FD-EPS patients., Methods: Ten FD-EPS patients (Roma III criteria) and ten HS were recruited into the study. Intragastric pressure (IGP) and gastric perfusion were measured and compared following the administration of liquid nutrients at 37 °C on day 1 and at 8 °C on day 2., Results: Seven patients developed abdominal discomfort or abdominal pain after being given cold liquid nutrient. The administration of liquid nutrient at 8 °C resulted in an increase of IGP in HS (P=0.044), a significant decrease in gastric perfusion (P<0.0001), a marked increase in IGP (P=0.015), and a dramatic reduction in gastric wall compliance (P=0.012) in patients compared to the effects of liquid nutrient at 37 °C. In addition, IGP in patients was lower than that in HS at 37 °C liquid nutrient (P=0.036), and the gastric perfusion volume in patients at maximal satiety was also significantly reduced at 8 °C liquid nutrient compared with HS (P=0.017)., Conclusions: Cold stimulation can increase the IGP in HS and FD-EPS patients, elevate the visceral sensitivity and reduce the gastric volume of FD-EPS patients. FD-EPS patients who are sensitive to cold may develop epigastric discomfort or pain.
- Published
- 2013
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35. Gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia.
- Author
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Yu J, Liu S, Fang XC, Zhang J, Gao J, Xiao YL, Zhu LM, Chen FR, Li ZS, Hu PJ, Ke MY, and Hou XH
- Subjects
- Adult, Anxiety epidemiology, China epidemiology, Dyspepsia drug therapy, Dyspepsia epidemiology, Female, Gastrointestinal Agents therapeutic use, Humans, Linear Models, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Prognosis, Risk Factors, Sex Factors, Sleep Wake Disorders epidemiology, Surveys and Questionnaires, Time Factors, Weight Loss, Dyspepsia diagnosis
- Abstract
Aim: To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD)., Methods: From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and Xi'an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally., Results: Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P < 0.001), and similar differences were found for all individual symptoms (P < 0.001). Multiple linear regression analysis showed that sex (P < 0.001), anxiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P < 0.001), consulting a physician (P < 0.001), and prokinetic use during 1-year follow-up (P = 0.035) were horizontally associated with DSS at 1-year follow-up. No relationship was found longitudinally between DSS at 1-year follow-up and patient characteristics at baseline., Conclusion: Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.
- Published
- 2013
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36. How to differentiate non-erosive reflux disease from functional heartburn.
- Author
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Ke MY
- Subjects
- Diagnosis, Differential, Endoscopy, Gastrointestinal, Esophageal pH Monitoring, Humans, Gastroesophageal Reflux diagnosis, Gastroesophageal Reflux drug therapy, Heartburn diagnosis, Heartburn drug therapy, Proton Pump Inhibitors therapeutic use
- Abstract
Heartburn is a common symptom in gastroesophageal reflux disease. Endoscopic examination can differentiate between reflux esophagitis and non-erosive reflux disease (NERD), but not between NERD and functional heartburn. With the development of new techniques, more NERD patients could be identified among those previously diagnosed with functional heartburn. Most patients with NERD, however, could be identified based on their clinical characteristics and response to proton pump inhibitors and/or integrated anti-gastroesophageal reflux therapy., (© 2012 The Author. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.)
- Published
- 2012
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37. [How to recognize and manage functional gastrointestinal disorders with concomitant psychological disorder].
- Author
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Ke MY
- Subjects
- Comorbidity, Gastrointestinal Diseases epidemiology, Humans, Mental Disorders epidemiology, Gastrointestinal Diseases diagnosis, Mental Disorders diagnosis
- Published
- 2012
38. [Symptomatic features and psychosocial factors in patients with belching disorders].
- Author
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Sun XM, Ke MY, Wang ZF, Zhang J, Fang XC, and Zhu LM
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Psychology, Social, Surveys and Questionnaires, Eructation diagnosis, Eructation psychology
- Abstract
Objective: To explore the symptomatic features and psychosocial factors in patients with belching disorders., Methods: At Peking Union Medical College Hospital Outpatient Clinic from September 2010 to January 2011, 21 consecutive patients with repetitive belching were profiled by symptom questionnaires, including general demographics, spectrum of symptoms, disease course, predisposing factors, previous treatment, psychosocial factors, mental status and personality traits, etc. Pearson's correlation analysis and exact probability were used., Results: Among them, 20 patients fulfilled the Rome III criteria of belching disorders. There were 5 males and 15 females with an age range of (49 ± 10) years. Among them, the belching patterns were daily (n = 18), meal-related (n = 16), spontaneous (n = 15), controllable (n = 16) and symptomatic overlapping (n = 17). The most common symptoms were functional dyspepsia (FD) (n = 13) and gastroesophageal reflux disease (GERD) (n = 11). Sixteen patients experienced mental stimulation/negative events and 13 patients were related to family tension, work stress and overwork. There were 12 patients with anxiety and/or depression and 8 with neurotic personality. The number of overlapping symptoms was related to anxiety states (r = 0.47, t = 2.14, P < 0.05). But the severity of belching was unrelated to with or without depression and anxiety state (P = 0.096)., Conclusions: There are a variety of clinical manifestations in patients with belching disorders. Belching disorders is often related to emotional change and environmental stress and accompanied by abnormal mental and personality characteristics. Belching may be an abnormal behavior reaction to gastrointestinal discomfort symptoms. The psychological and social factors probably play an important role in the pathogenesis of belching disorders.
- Published
- 2012
39. [Multi-centered stratified clinical studies for psychological and sleeping status in patients with chronic constipation in China].
- Author
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Zhu LM, Fang XC, Liu S, Zhang J, Li ZS, Hu PJ, Gao J, Xin HW, and Ke MY
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, China epidemiology, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Young Adult, Constipation epidemiology, Constipation psychology, Mental Disorders epidemiology, Sleep
- Abstract
Objective: To survey the emotional and sleeping status of patients with chronic constipation (CC) and analyze the relationship between psychological status and constipated symptoms., Methods: From January 2009 to April 2010, 5 centers and 25 stratified hospitals were selected as the representatives of different regions of mainland China. The CC questionnaires including constipated symptoms, emotional and sleeping status, previous treatments and self-reported impact of constipation on health status, etc. Questionnaires were completed by well-trained physicians or investigators during face-to-face interviews. CC was diagnosed in accordance with the Rome III criteria., Results: A total of 909 valid questionnaires analyzed. There were 258 males and 651 females with a mean age of (49 ± 19) years. 41.5% (377 cases) reported "tense feelings" and 38.3% (348 cases) "felt downcast" over the past 3 months. The patients feeling tense and(or) downcast "frequently" and "most of time" were around 11.3% (103 cases) and 9.4% (85 cases). And 43.8% (398 cases) patients reported sleeping disorders over the past 3 months. Regional differences existed in the comorbidities of psychological and sleeping disorders in CC patients, especially in those from tertiary hospitals. And it was the highest in Beijing area for tense feelings and downcast. The sleeping disorders were the most common in the patients from secondary hospitals, of which 66.1% (37/56) and 65.0% (39/60) were from Wuhan and Xi'an respectively. They were higher than Beijing and Guangzhou (39.7% (23/58), 29.0% (9/31), all P = 0.001). The patients from rural primary clinics suffered more sleeping disorders than those from urban primary cares (P = 0.026). About 35.0% (318 cases) and 28.4% (258 cases) patients reported their constipation was related with emotional and sleeping disorders. The comorbidities of psychological and sleeping disorders were more common in severe constipated patients than mild and moderate counterparts and resulted in more hospital visits (both P = 0.000)., Conclusions: The CC patients often have the comorbidities of psychological and sleeping disorders with regional differences. The patients from the hospitals at various levels may present different spectrums of comorbidities of psychological and sleeping disorders. And the severity of CC influences the moods, sleeps and hospital visits.
- Published
- 2012
40. [Clinical application of high resolution manometry for examining esophageal function in neonates].
- Author
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Li ZH, Wang DH, Dong M, Ke MY, and Wang ZF
- Subjects
- Deglutition physiology, Esophageal Sphincter, Lower physiology, Esophageal Sphincter, Upper physiology, Female, Humans, Infant, Newborn, Male, Peristalsis, Esophagus physiology, Manometry methods
- Abstract
Objective: To examine the esophageal function of neonates by high resolution manometry (HRM), and to provide preliminary data for research on the esophageal function of neonates., Methods: Esophageal HRM was performed on neonates using a solid-state pressure measurement system with 36 circumference sensors arranged at intervals of 0.75 cm, and ManoView software was used to analyze esophageal peristalsis pattern., Results: Esophageal HRM was performed successfully in 11 neonates, and 126 occurrences of complete esophageal peristalsis were recorded. Complete esophageal peristalsis with pressure increase was recorded in some neonates but most neonates showed a different esophageal peristalsis pattern compared with adults. Some neonates had no relaxation of the upper esophageal sphincter (UES) when pharyngeal muscles contracted in swallowing, some neonates had multiple swallowing without esophageal peristalsis and some neonates had relatively low pressure of esophageal peristalsis. Full-term infants could have relatively low UES pressure and esophageal sphincter (LES) pressure but some preterm infants showed relatively high UES pressure and LES pressure. Longitudinal contraction of the whole esophagus and elevation of LES after swallowing were recorded in some neonates., Conclusions: Esophageal HRM is safe and tolerable for neonates. HRM shows that esophageal peristalsis after swallowing may not occur or may be incomplete in neonates. The esophageal function of neonates has not yet been developed completely, with large individual differences in esophageal peristalsis. Large sample data are needed for further analysis and research on the esophageal function of neonates.
- Published
- 2012
41. Chinese National Consensus on diagnosis and management of Barrett's esophagus (BE): revised edition, June 2011, Chongqing, China.
- Author
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Fang DC, Lin SR, Huang Q, Yu ZL, Yuan YZ, Chen MH, Bai WY, Chen XX, Zhang J, Li YQ, Zhou LY, Ke MY, Fang XC, and Lan Y
- Subjects
- Barrett Esophagus pathology, Biopsy, China, Endoscopy, Digestive System, Humans, Societies, Medical, Barrett Esophagus diagnosis, Barrett Esophagus therapy, Disease Management
- Abstract
To standardize the diagnosis and management of Barrett's esophagus (BE) in China, the Chinese Society of Gastroenterology convened the Second National Conference on BE in June 2011 in Chongqing, China. After intense discussion among experts in this field and an extensive review of the literature, a revised consensus on the diagnosis and management of BE was generated., (© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.)
- Published
- 2011
- Full Text
- View/download PDF
42. [Preliminary investigation of risk stratification and prognosis of B-type brain natriuretic peptide in patients with sepsis].
- Author
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Huang ZJ, Ke MY, Kang LJ, He F, Chen YR, and Xie HQ
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Prognosis, Risk Factors, Natriuretic Peptide, Brain blood, Sepsis diagnosis, Sepsis etiology
- Published
- 2011
43. Investigation of low-temperature electroluminescence of InGaN/GaN based nanorod light emitting arrays.
- Author
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Huang YY, Chen LY, Chang CH, Sun YH, Cheng YW, Ke MY, Lu YH, Kuo HC, and Huang J
- Abstract
For InGaN/GaN based nanorod devices using a top-down etching process, the optical output power is affected by non-radiative recombination due to sidewall defects (which decrease light output efficiency) and the mitigated quantum confined Stark effect (QCSE) due to strain relaxation (which increases internal quantum efficiency). Therefore, the exploration of low-temperature optical behaviors of nanorod light emitting diodes (LEDs) will help identify the correlation between these two factors. In this work, low-temperature electroluminescent (EL) spectra of InGaN/GaN nanorod arrays were explored and compared with those of planar LEDs. The nanorod LED exhibits a much higher optical output percentage increase when the temperature decreases. The increase is mainly attributed to the increased carriers in the quantum wells for radiative recombination. Also, due to a better spatial overlap of electrons and holes in the quantum wells, the increased number of carriers can be more efficiently recombined in the nanorod device. Next, while the nanorod array shows nearly constant peak energy in the EL spectra at various injection currents at the temperature of 300 K, a blue shift has been observed at 190 K. The results suggest that with less non-radiative recombination and thus more carriers in the quantum wells, carrier screening and band filling still prevail in the partially strain relaxed nanorods. Moreover, when the temperature drops to 77 K, the blue shift of both nanorod and planar devices disappears and the optical output power decreases since there are fewer carriers in the quantum wells for radiative recombination.
- Published
- 2011
- Full Text
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44. Characterizations of low-temperature electroluminescence from ZnO nanowire light-emitting arrays on the p-GaN layer.
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Lu TC, Ke MY, Yang SC, Cheng YW, Chen LY, Lin GJ, Lu YH, He JH, Kuo HC, and Huang J
- Abstract
Low-temperature electroluminescence from ZnO nanowire light-emitting arrays is reported. By inserting a thin MgO current blocking layer in between ZnO nanowire and p-GaN, high-purity UV light emission at wavelength 398 nm was obtained. As the temperature is decreased, contrary to the typical GaN-based light emitting diodes, our device shows a decrease of optical output intensity. The results are associated with various carrier tunneling processes and frozen MgO defects.
- Published
- 2010
- Full Text
- View/download PDF
45. Investigation of light absorption properties and acceptance angles of nanopatterned GZO/a-Si/p(+)-Si photodiodes.
- Author
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Chen CP, Lin PH, Hung YJ, Hsu SS, Chen LY, Cheng YW, Ke MY, Huang YY, Chang CH, Chiu CH, Kuo HC, and Huang J
- Abstract
In this work, n-GZO/a:amorphous-Si(i:intrinsic)/p( + )-Si photodiodes are fabricated. We employed a nanosphere lithographic technique to obtain nanoscale patterns on either the a-Si(i) or p( + )-Si surface. As compared with the planar n-GZO/p( + )-Si diode, the devices with nanopatterned a-Si(i) and nanopatterned p( + )-Si substrates show a 32% and 36.2% enhancement of photoresponsivity. Furthermore, the acceptance angle measurement reveals that the nanostructured photodiodes have larger acceptance angles than the planar structure. It also shows that the device with the nanocone structure has a higher acceptance angle than that with the nanorod structure.
- Published
- 2010
- Full Text
- View/download PDF
46. High performance InGaN/GaN nanorod light emitting diode arrays fabricated by nanosphere lithography and chemical mechanical polishing processes.
- Author
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Chen LY, Huang YY, Chang CH, Sun YH, Cheng YW, Ke MY, Chen CP, and Huang J
- Abstract
We fabricated InGaN/GaN nanorod light emitting diode (LED) arrays using nanosphere lithography for nanorod formation, PECVD (plasma enhanced chemical vapor deposition) grown SiO(2) layer for sidewall passivation, and chemical mechanical polishing for uniform nanorod contact. The nano-device demonstrates a reverse current 4.77nA at -5V, an ideality factor 7.35, and an optical output intensity 6807mW/cm(2) at the injection current density 32A/cm(2) (20mA). Moreover, the investigation of the droop effect for such a nanorod LED array reveals that junction heating is responsible for the sharp decrease at the low current.
- Published
- 2010
- Full Text
- View/download PDF
47. [Evaluation of gastric sensitivity and accommodation by simultaneous determination of intra-gastric pressure in liquid load test].
- Author
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Song ZQ, Ke MY, Wang ZF, Fang XC, and Liu XH
- Subjects
- Adult, Case-Control Studies, Dyspepsia diagnosis, Female, Gastric Emptying, Humans, Hyperesthesia diagnosis, Male, Middle Aged, Dyspepsia physiopathology, Hyperesthesia physiopathology, Stomach physiopathology
- Abstract
Objective: To extensively evaluate the method of simultaneous determination of intra-gastric pressure (IGP) in liquid load test (LLT) in healthy subjects (HS) and patients with functional dyspepsia (FD)., Methods: Forty HS and 67 FD patients (Rome III criteria) were recruited. All subjects were surveyed with regards to demographic characteristics, features of FD symptom spectrum and psychological status (Zung anxiety and depression scale). And the test of simultaneous determination of IGP in LLT was conducted. Finally all the data were collected and analyzed., Results: HS group: no statistical difference was found in IGP divided by gender, age and body mass index (P > 0.05). The coefficient of variation of IGP at 15.3% was less than that of maximal intake volume (MIV). Twice repeated studies showed quite similar results and the linear interclass correlation coefficient of IGP was 0.806 (P = 0.002). As to the range of normal value from HS, the proportion of gastric hypersensitivity accounted for 35.0% and impaired accommodation for 25.0%. FD group: no statistical difference was found in IGP and MIV divided by gender, age and FD symptom subtype (P > 0.05). FD patients with abnormal psychological status had a lower IGP (4.2 +/- 1.2 mm Hg vs 4.8 +/- 1.1 mm Hg, P = 0.042) and MIV (450 +/- 138 ml vs 526 +/- 121 ml, P = 0.034) than those with normal status. IGP was not related to epigastric pain, epigastric burning, postprandial fullness or early satiation (F = 1.635, P = 0.190). Early satiation was significantly related to MIV (F = 4.682, P = 0.031; correlation coefficient was -6.8, P = 0.033). No statistical difference was found in gastric compliance among HS, all FD patients, patients with hypersensitivity or impaired accommodation (P > 0.05). The test had an excellent safety and tolerability., Conclusions: The method of simultaneous determination of IGP in LLT can differentiate gastric hypersensitivity from impaired accommodation. And it has an excellent feasibility, safety and reliability.
- Published
- 2010
48. UV light emission from GZO/ZnO/GaN heterojunction diodes with carrier confinement layers.
- Author
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Ke MY, Lu TC, Yang SC, Chen CP, Cheng YW, Chen LY, Chen CY, He JH, and Huang J
- Subjects
- Computer-Aided Design, Equipment Design, Equipment Failure Analysis, Ultraviolet Rays, Lighting instrumentation, Semiconductors
- Abstract
In this work, GZO/ZnO/GaN diodes with the light emitting ZnO layer sandwiched between two SiO(2) thin films was fabricated and characterized. We observed a strong excitonic emission at the wavelength 377nm with the Mg(2+) deep level transition and oxygen vacancy induced recombination significantly suppressed. In comparison, light emission from the GZO/GaN device (without SiO(2) barriers) is mainly dominant by defect radiation. Furthermore, the device with confinement layers demonstrated a much higher UV intensity than the blue-green emission of the GZO/GaN p-n device.
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- 2009
- Full Text
- View/download PDF
49. [Long-term impact on quality of life in patients with gastroesophageal reflux disease after 52-week rabeprazole treatment].
- Author
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Yang XL, Liu XH, Ke MY, Song ZQ, Yuan YZ, Luo JY, and Hou XH
- Subjects
- Adult, Aged, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Rabeprazole, Treatment Outcome, 2-Pyridinylmethylsulfinylbenzimidazoles therapeutic use, Anti-Ulcer Agents therapeutic use, Gastroesophageal Reflux drug therapy, Quality of Life
- Abstract
Objective: To investigate the longitudinal changes in quality of life (QoL) for gastroesophageal reflux disease (GERD) treated with 52-week rabeprazole over a period of 2-3 years., Methods: A multi-center, open-label and randomized 52-week rabeprazole trial was conducted in 67 eosinophilic esophagitis (EE) and 31 non-erosive reflux disease (NERD) patients. The follow-up period is 2-3 years after the treatment. Their QoL were evaluated using SF-36 Health Survey Questionnaire and GERD-HRQL scale. The results were compared with those acquired before and after a 52-week proton pump inhibitor (PPI) treatment., Results: (1) Both EE and NERD patients improved significantly according to GERD-HRQL scale in scores of reflux symptoms as well as overall satisfaction (12.5 vs 3.5, 20.0 vs 14.0, both P < 0.01) versus the pre-therapy baseline. (2) Both EE and NERD patients had no significant difference in the scale of GERD-HRQL (2.0 vs 3.5, 5.0 vs 4.0, both P > 0.05) and most major domains of SF-36 questionnaire versus the post-therapy baseline (53 +/- 17 vs 61 +/- 17, t = -2.143, P = 0.035). (3) The NERD patients had a higher score of reflux symptoms than the EE patients according to the GERD-HRQL Scale (14.0 vs 3.5, Z = 2.377, P = 0.017), however there were no significant differences between NERD and EE in 8 major domains of SF-36 questionnaire (P > 0.05)., Conclusion: Long-term and low-dose PPI treatment achieves improvement both in reflux symptoms and QoL in GERD patients and such effects last a long time. At follow-ups, the reflux symptoms of NERD patients are more severe than EE patients. However, the overall QoL has shown little differences between these two subtypes.
- Published
- 2009
50. Nanoparticle-coated n-ZnO/p-Si photodiodes with improved photoresponsivities and acceptance angles for potential solar cell applications.
- Author
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Chen CP, Lin PH, Chen LY, Ke MY, Cheng YW, and Huang J
- Subjects
- Electric Power Supplies, Equipment Design, Equipment Failure Analysis, Light, Macromolecular Substances chemistry, Materials Testing, Molecular Conformation, Nanostructures radiation effects, Nanostructures ultrastructure, Particle Size, Silicon radiation effects, Surface Properties, Zinc Oxide radiation effects, Crystallization methods, Lighting instrumentation, Nanostructures chemistry, Nanotechnology instrumentation, Semiconductors, Silicon chemistry, Zinc Oxide chemistry
- Abstract
In this work, n-ZnO/p-Si photodiodes were fabricated and characterized to explore their potential applications in solar cells. With a coating of silica nanoparticles, we observed the enhancement of photoresponsivity and acceptance angle at a wavelength between 400 and 650 nm. The 17.6% increase of the photoresponsivity over the conventional device is due to the improved optical transmission toward the semiconductor through the silica nanoparticles. Furthermore, the acceptance angle of the nanoparticle coated device is dramatically increased, which is attributed to the effect of Bragg diffraction.
- Published
- 2009
- Full Text
- View/download PDF
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