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This article synthesises the practice and rationale behind ways of facilitating gatherings on topics of societal disruption and collapse, which is argued to be useful for lessening damaging responses. The authors draw on first-person inquiry as facilitators of gatherings, both online and in person, in the post-sustainability field of ‘Deep Adaptation,’ particularly since 2018. This term describes an agenda and framework for people who believe in the probable, inevitable or unfolding collapse of industrial consumer societies, due to the direct and indirect impacts of human-caused climate change and environmental degradation. Some of the principles of Deep Adaptation facilitation are summarised, such as containment, to enable co-responsibility for a safe enough space for difficult conversations. Another key principle is welcoming radical uncertainty in response to the anxieties that people feel from their anticipation of collapse. A third principle is making space for difficult emotions, which are welcomed as a natural and ongoing response to our predicament. A fourth aspect is a curiosity about processes of othering and separation. This paper provides a review of the theories that a reason for environmental destruction is the process of othering people and nature as being less significant or meaningful. One particular modality called Deep Relating is outlined.

Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. 1H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated 1H MRS method to compare the compositional saturation index (CH2:CH3) and concentration independent of the composition (CH3) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n = 14) and healthy controls (n = 41). The IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH2:CH3 was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH2:CH3adj), could distinguish lipodystrophics from athletes. This CH2:CH3adj marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO2max. The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states.

What is the role of schools, and more specifically school leadership, in the transition to a sustainable future for humankind? What different forms of leadership are needed to enable this role? The challenges are huge and complex and for those of us engaged in promoting sustainability learning, it is clear that the issue has never been more pressing. Action at government and corporate level is required, as well as an immense shift in patterns of consumption, especially in richer countries. This paper aims to explore the nature, challenges and opportunities of sustainability leadership within the context of formal education in the UK. A critical pedagogy (Freire, 1970; Gatto, 1992) lens is used to explore ways in which the formal education system is constructed on mental models that are inherently unsustainable, and that reinforce the principles of hierarchy, power and control, separation, competition and colonialism that are at the root of sustainability challenges. Drawing on interviews with school leaders, some possibilities will be explored, such as alternative pedagogies that create space for relaxed, collaborative, co-constructive learning, that encourage critical thinking, and reignite children’s sense of connection with each other and with the environment (Woodlin, 2014).

This is a reply to:Pihkala, Panu. 2017. “Environmental education after sustainability: hope in the midst of tragedy.” Global Discourse. 7 (1): 109–127. http://dx.doi.org/10.1080/23269995.2017.1300412.

ContextParadoxically, intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and to insulin-sensitive (athletes) states. The composition of this lipid store is unknown in these states.Design and MethodsWe used a recently validated and potentially widely applicable 1H magnetic resonance spectroscopy method to compare the compositional saturation index (CH2:CH3 ratio) and concentration independent of composition (CH3) of intramyocellular lipid in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic patients with that of age- and gender-matched athletes (n=14) and healthy controls (n = 41).Main OutcomeIMCL compositional saturation index (CH2:CH3 ratio).ResultsThe IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic patients compared with age- and gender-matched controls but not compared to athletes. IMCL CH2:CH3 was dependent on IMCL concentration in the controls and after adjusting the composition index for quantity (CH2:CH3adj) was able to distinguish patients from athletes. With groups pooled, this CH2:CH3adj marker had the strongest relation to insulin resistance (HOMA-IR) compared to other measures of lipid concentration and composition, especially in the soleus muscle. Contrary to the ‘athlete’s paradox’, IMCL in athletes was similar in tibialis anterior (p>0.05) and significantly lower in the soleus (p < 0.004) compared to both controls and patients.ConclusionsThe IMCL saturation index adjusted for quantity, which likely reflects accumulation of saturated IMCL, is more closely associated with insulin resistance than concentration alone.

Research measuring levels of enforcement has investigated whether increases in police activities (e.g., checkpoints, driving-while-intoxicated [DWI] special patrols) above some baseline level are associated with reduced crashes and fatalities. Little research, however, has attempted to quantitatively measure enforcement efforts and relate different enforcement levels to specific levels of the prevalence of alcohol-impaired driving.The objective of this study was to investigate the effects of law-enforcement intensity in a sample of communities on the rate of crashes involving a drinking driver. We analyzed the influence of different enforcement strategies and measures: (1) specific deterrence - annual number of driving-under-the-influence (DUI) arrests per capita; (2) general deterrence - frequency of sobriety checkpoint operations; (3) highly visible traffic enforcement - annual number of traffic stops per capita; (4) enforcement presence - number of sworn officers per capita; and (5) overall traffic enforcement - the number of other traffic enforcement citations per capita (i.e., seat belt citations, speeding tickets, and other moving violations and warnings) in each community.We took advantage of nationwide data on the local prevalence of impaired driving from the 2007 National Roadside Survey (NRS), measures of DUI enforcement activity provided by the police departments that participated in the 2007 NRS, and crashes from the General Estimates System (GES) in the same locations as the 2007 NRS. We analyzed the relationship between the intensity of enforcement and the prevalence of impaired driving crashes in 22-26 communities with complete data. Log-linear regressions were used throughout the study.A higher number of DUI arrests per 10,000 driving-aged population was associated with a lower ratio of drinking-driver crashes to non-drinking-driver crashes (p=0.035) when controlling for the percentage of legally intoxicated drivers on the roads surveyed in the community from the 2007 NRS. Results indicate that a 10% increase in the DUI arrest rate is associated with a 1% reduction in the drinking driver crash rate. Similar results were obtained for an increase in the number of sworn officers per 10,000 driving-age population.While a higher DUI arrest rate was associated with a lower drinking-driver crash rate, sobriety checkpoints did not have a significant relationship to drinking-driver crashes. This appeared to be due to the fact that only 3% of the on-the-road drivers were exposed to frequent sobriety checkpoints (only 1 of 36 police agencies where we received enforcement data conducted checkpoints weekly). This low-use strategy is symptomatic of the general decline in checkpoint use in the U.S. since the 1980s and 1990s when the greatest declines in alcohol-impaired-driving fatal crashes occurred. The overall findings in this study may help law enforcement agencies around the country adjust their traffic enforcement intensity in order to reduce impaired driving in their community.

In 1704, after causing much outrage as a young man by flaunting his spurious religious beliefs, murdering a man in a duel and failing to come up with the elusive 'universal cure', Johann Konrad Dippel finally produced something of note: Prussian blue ink. Although its discovery resulted from accident rather than systematic research, Prussian blue ink had many uses, including the detection of metal poisoning, for which it is still used today. Also renowned for his interest in dissecting cadavers, his attempt at 'soul transference' using dead bodies and his murky association with Mary Shelley's Frankenstein, Dippel seems somewhat more of a 'sinner' than a 'saint'.

Novel immunohistochemistry biomarkers that target specific cellular proteins that are either uniquely or primarily expressed by cancer cells are being developed. One of these biomarkers, caPCNA, [the cancer associated isoform of PCNA] may be useful as an aide for distinguishing early stage neoplasia from hyperplasia in clinical cases that are often difficult to interpret. The caPCNA isoform appears to be expressed almost exclusively in a large variety of cancer cells and at all Stages [1 to 4] of the disease. It is not consistently observed in most normal adjacent tissues. This study analyzed the expression of caPCNA, by immunohistochemistry (IHC) using an automated Ventana immunostaining platform. In the present study, IHC was performed on neutral buffered formalin fixed paraffin embedded tissues obtained from various pathology labs. Evaluation of carcinomas (120 cases) from various organs and clinical stages as well as normal adjacent tissue was performed. Immunostaining was localized in tumor cells only to the cell nucleus. CaPCNA expression was seen in 10 of 10 cervical Ca, 20 of 20 colon Ca, 10 of 10 thyroid Ca, 10 of 10 gastric Ca, 10 of 10 ovarian Ca, 25 of 25 breast Ca, 10 of 10 lung Ca, 11 of 12 uterine Ca, and 15 of 15 DCIS Ca. On a normal tissue panel, caPCNA immunostaining was seen in macrophages, syncytial trophoblasts in the placenta, GI tract crypt epithelial cells, and scattered staining in the basilar layer of the skin. Immunostaining of normal macrophages and most of the other reactive cell types was abolished by removal of the heavy chain of the primary antibody during creation of an Fab2' fragment of the anti-caPCNA antibody. In summary, the present results illustrate the localization of caPCNA at all stages, in many different types of neoplasms. CaPCNA may therefore be a useful biomarker for early stage cancer diagnosis and potentially maybe a predictor of patient outcome. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4629.