Back to Search
Start Over
Accumulation of saturated intramyocellular lipid is associated with insulin resistance
- Source :
- Journal of Lipid Research, Journal of Lipid Research, Vol 60, Iss 7, Pp 1323-1332 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and insulin-sensitive (athletes) states. Biochemical analysis of intramuscular triglyceride composition is confounded by extramyocellular triglycerides in biopsy samples, and hence the specific composition of IMCLs is unknown in these states. 1H magnetic resonance spectroscopy (MRS) can be used to overcome this problem. Thus, we used a recently validated 1H MRS method to compare the compositional saturation index (CH2:CH3) and concentration independent of the composition (CH3) of IMCLs in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic subjects with that of age- and gender-matched athletes (n = 14) and healthy controls (n = 41). The IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic subjects compared with controls but was similar in athletes and controls. IMCL CH2:CH3 was dependent on the IMCL concentration in the controls and, after adjusting the compositional index for quantity (CH2:CH3adj), could distinguish lipodystrophics from athletes. This CH2:CH3adj marker had a stronger relationship with insulin resistance than IMCL concentration alone and was inversely related to VO2max. The association of insulin resistance with the accumulation of saturated IMCLs is consistent with a potential pathogenic role for saturated fat and the reported benefits of exercise and diet in insulin-resistant states.
- Subjects :
- Adult
Male
0301 basic medicine
spectroscopy
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Lipodystrophy
muscle
Lipid composition
Saturated fat
QD415-436
lipid composition
030204 cardiovascular system & hematology
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Insulin resistance
Heart Rate
Internal medicine
lipodystrophies
medicine
Humans
Insulin
Choline-Phosphate Cytidylyltransferase
610 Medicine & health
Muscle, Skeletal
triglycerides
exercise
Triglyceride
Fatty Acids
Cell Biology
Lamin Type A
medicine.disease
Saturation index
in vivo
030104 developmental biology
chemistry
Female
lipids (amino acids, peptides, and proteins)
Insulin Resistance
Patient-Oriented and Epidemiological Research
Subjects
Details
- ISSN :
- 00222275
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Journal of Lipid Research
- Accession number :
- edsair.doi.dedup.....4bceb3ea762fbcc0fcecb9fe52204c30