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The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array observing the Cosmic Microwave Background (CMB) at frequency bands centered near 40, 90, 150, and 220 GHz. CLASS measures the CMB polarization on the largest angular scales to constrain the inflationary tensor-to-scalar ratio and the optical depth due to reionization. To achieve the long time-scale stability necessary for this measurement from the ground, CLASS utilizes a front-end, variable-delay polarization modulator on each telescope. Here we report on the improvements in stability afforded by front-end modulation using data across all four CLASS frequencies. Across one month of modulated linear polarization data in 2021, CLASS achieved median knee frequencies of 9.1, 29.1, 20.4, and 36.4 mHz for the 40, 90, 150, and 220 GHz observing bands. The knee frequencies are approximately an order of magnitude lower than achieved via CLASS pair-differencing orthogonal detector pairs without modulation., Comment: Submitted to SPIE Astronomical Telescopes + Instrumentation 2022 Conference (AS22)

The Simons Observatory is a ground-based cosmic microwave background survey experiment that consists of three 0.5 m small-aperture telescopes and one 6 m large-aperture telescope, sited at an elevation of 5200 m in the Atacama Desert in Chile. SO will deploy 60,000 transition-edge sensor (TES) bolometers in 49 separate focal-plane modules across a suite of four telescopes covering 30/40 GHz low frequency (LF), 90/150 GHz mid frequency (MF), and 220/280 GHz ultra-high frequency (UHF). Each MF and UHF focal-plane module packages 1720 optical detectors spreading across 12 detector bias lines that provide voltage biasing to the detectors. During observation, detectors are subject to varying atmospheric emission and hence need to be re-biased accordingly. The re-biasing process includes measuring the detector properties such as the TES resistance and responsivity in a fast manner. Based on the result, detectors within one bias line then are biased with suitable voltage. Here we describe a technique for re-biasing detectors in the modules using the result from bias-step measurement.

The Simons Observatory (SO) is a ground-based cosmic microwave background (CMB) survey experiment that consists of three 0.5 m small-aperture telescopes (SATs) and one 6 m large-aperture telescope (LAT), sited at an elevation of 5200 m in the Atacama Desert in Chile. In order to meet the sensitivity requirements set for next-generation CMB telescopes, the LAT will deploy 30,000 transition edge sensor (TES) detectors at 100 mK across 7 optics tubes (OT), all within the Large Aperture Telescope Receiver (LATR). Additionally, the LATR has the capability to expand to 62,000 TES across 13 OTs. The LAT will be capable of making arcminute-resolution observations of the CMB, with detector bands centered at 30, 40, 90, 150, 230, and 280 GHz. We have rigorously tested the LATR systems prior to deployment in order to fully characterize the instrument and show that it can achieve the desired sensitivity levels. We show that the LATR meets cryogenic and mechanical requirements, and maintains acceptably low baseline readout noise.

The Simons Observatory (SO) is a ground based Cosmic Microwave Background experiment that will be deployed to the Atacama Desert in Chile. SO will field over 60,000 transition edge sensor (TES) bolometers that will observe in six spectral bands between 27 GHz and 280 GHz with the goal of revealing new information about the origin and evolution of the universe. SO detectors are grouped based on their observing frequency and packaged into Universal Focal Plane Modules, each containing up to 1720 detectors which are read out using microwave SQUID multiplexing and the SLAC Microresonator Radio Frequency Electronics (\smurf). By measuring the complex impedance of a TES we are able to access many thermoelectric properties of the detector that are difficult to determine using other calibration methods, however it has been difficult historically to measure complex impedance for many detectors at once due to high sample rate requirements. Here we present a method which uses \smurf\ to measure the complex impedance of hundreds of detectors simultaneously on hour-long timescales. We compare the measured effective thermal time constants to those estimated independently with bias steps. This new method opens up the possibility for using this characterization tool both in labs and at the site to better understand the full population of SO detectors.

We present near-field radio holography measurements of the Simons Observatory Large Aperture Telescope Receiver optics. These measurements demonstrate that radio holography of complex millimeter-wave optical systems comprising cryogenic lenses, filters, and feed horns can provide detailed characterization of wave propagation before deployment. We used the measured amplitude and phase, at 4 K, of the receiver near-field beam pattern to predict two key performance parameters: 1) the amount of scattered light that will spill past the telescope to 300 K and 2) the beam pattern expected from the receiver when fielded on the telescope. These cryogenic measurements informed the removal of a filter, which led to improved optical efficiency and reduced sidelobes at the exit of the receiver. Holography measurements of this system suggest that the spilled power past the telescope mirrors will be less than 1%, and the main beam with its near sidelobes are consistent with the nominal telescope design. This is the first time such parameters have been confirmed in the lab prior to deployment of a new receiver. This approach is broadly applicable to millimeter and submillimeter instruments.

The Cosmology Large Angular Scale Surveyor (CLASS) observes the polarized cosmic microwave background (CMB) over the angular scales of 1$^\circ \lesssim \theta \leq$ 90$^\circ$ with the aim of characterizing primordial gravitational waves and cosmic reionization. We report on the on-sky performance of the CLASS Q-band (40 GHz), W-band (90 GHz), and dichroic G-band (150/220 GHz) receivers that have been operational at the CLASS site in the Atacama desert since June 2016, May 2018, and September 2019, respectively. We show that the noise-equivalent power measured by the detectors matches the expected noise model based on on-sky optical loading and lab-measured detector parameters. Using Moon, Venus, and Jupiter observations, we obtain power-to-antenna-temperature calibrations and optical efficiencies for the telescopes. From the CMB survey data, we compute instantaneous array noise-equivalent-temperature sensitivities of 22, 19, 23, and 71 $\mathrm{\mu K}_\mathrm{cmb}\sqrt{\mathrm{s}}$ for the 40, 90, 150, and 220 GHz frequency bands, respectively. These noise temperatures refer to white noise amplitudes, which contribute to sky maps at all angular scales. Future papers will assess additional noise sources impacting larger angular scales., Comment: 13 pages, 3 figures, published in ApJ

The current and future cosmic microwave background (CMB) experiments fielding kilo-pixel arrays of transition-edge sensor (TES) bolometers require accurate and robust gain calibration methods. We simplify and refactor the standard TES model to directly relate the detector responsivity calibration and optical time constant to the measured TES current $I$ and the applied bias current $I_{\mathrm{b}}$. The calibration method developed for the Cosmology Large Angular Scale Surveyor (CLASS) TES bolometer arrays relies on current versus voltage ($I$-$V$) measurements acquired daily prior to CMB observations. By binning Q-band (40GHz) $I$-$V$ measurements by optical loading, we find that the gain calibration median standard error within a bin is 0.3%. We test the accuracy of this "$I$-$V$ bin" detector calibration method by using the Moon as a photometric standard. The ratio of measured Moon amplitudes between detector pairs sharing the same feedhorn indicates a TES calibration error of 0.5%. We also find that for the CLASS Q-band TES array, calibrating the response of individual detectors based solely on the applied TES bias current accurately corrects TES gain variations across time but introduces a bias in the TES calibration from data counts to power units. Since the TES current bias value is set and recorded before every observation, this calibration method can always be applied to raw TES data and is not subject to $I$-$V$ data quality or processing errors., Comment: 19 pages, 7 figures, 5 tables. Submitted to ApJS May 2022. Published ApJS Oct 2022

The Simons Observatory (SO) will be a cosmic microwave background (CMB) survey experiment with three small-aperture telescopes and one large-aperture telescope, which will observe from the Atacama Desert in Chile. In total, SO will field over 60,000 transition-edge sensor (TES) bolometers in six spectral bands centered between 27 and 280 GHz in order to achieve the sensitivity necessary to measure or constrain numerous cosmological quantities, as outlined in The Simons Observatory Collaboration et al. (2019). The 6~m Large Aperture Telescope (LAT), which will target the smaller angular scales of the CMB, utilizes a cryogenic receiver (LATR) designed to house up to 13 individual optics tubes. Each optics tube is comprised of three silicon lenses, IR blocking filters, and three dual-polarization, dichroic TES detector wafers. The scientific objectives of the SO project require these optics tubes to achieve high-throughput optical performance while maintaining exquisite control of systematic effects. We describe the integration and testing program for the SO LATR optics tubes that will verify the design and assembly of the optics tubes before they are shipped to the SO site and installed in the LATR cryostat. The program includes a quick turn-around test cryostat that is used to cool single optics tubes and validate the cryogenic performance and detector readout assembly. We discuss the optical design specifications the optics tubes must meet to be deployed on sky and the suite of optical test equipment that is prepared to measure these requirements.

We present the design and measured performance of a new carbon fiber strut design that is used in a cryogenically cooled truss for the Simons Observatory small aperture telescope. The truss consists of two aluminum 6061 rings separated by 24 struts. Each strut consists of a central carbon fiber tube fitted with two aluminum end caps. We tested the performance of the strut and truss by (i) cryogenically cycling and destructively pull-testing strut samples, (ii) non-destructively pull-testing the final truss, and (iii) measuring the thermal conductivity of the carbon fiber tubes. We found that the strut strength is limited by the mounting fasteners and the strut end caps, not the epoxy adhesive or the carbon fiber tube. This result is consistent with our numerical predictions. Our thermal measurements suggest that the conductive heat load through the struts (from 4 to 1 K) will be less than 1 mW. This strut design may be a promising candidate for use in other cryogenic support structures.

Using the Cosmology Large Angular Scale Surveyor, we measure the disk-averaged absolute Venus brightness temperature to be 432.3 $\pm$ 2.8 K and 355.6 $\pm$ 1.3 K in the Q and W frequency bands centered at 38.8 and 93.7 GHz, respectively. At both frequency bands, these are the most precise measurements to date. Furthermore, we observe no phase dependence of the measured temperature in either band. Our measurements are consistent with a CO$_2$-dominant atmospheric model that includes trace amounts of additional absorbers like SO$_2$ and H$_2$SO$_4$., Comment: 7 pages, 3 figures, published in PSJ

The Simons Observatory (SO) is a cosmic microwave background (CMB) experiment from the Atacama Desert in Chile comprising three small-aperture telescopes (SATs) and one large-aperture telescope (LAT). In total, SO will field over 60,000 transition-edge sensor (TES) bolometers in six spectral bands centered between 27 and 280 GHz in order to achieve the sensitivity necessary to measure or constrain numerous cosmological quantities. In this work, we focus on the SATs which are optimized to search for primordial gravitational waves that are detected as parity-odd polarization patterns called a B-modes on degree scales in the CMB. Each SAT employs a single optics tube with TES arrays operating at 100 mK. The high throughput optics system has a 42 cm aperture and a 35-degree field of view coupled to a 36 cm diameter focal plane. The optics consist of three metamaterial anti-re ection coated silicon lenses. Cryogenic ring baffles with engineered blackbody absorbers are installed in the optics tube to minimize the stray light. The entire optics tube is cooled to 1 K. A cryogenic continuously rotating half-wave plate near the sky side of the aperture stop helps to minimize the effect of atmospheric uctuations. The telescope warm baffling consists of a forebaffle, an elevation stage mounted co-moving shield, and a fixed ground shield that together control the far side-lobes and mitigates ground-synchronous systematics. We present the status of the SAT development., Comment: 8 pages, 6 figures

The Simons Observatory (SO) is an upcoming polarized cosmic microwave background (CMB) survey experiment with three small-aperture telescopes and one large-aperture telescope that will observe from the Atacama Desert in Chile. In total, SO will field over 60,000 transition-edge sensor (TES) bolometers in six spectral bands centered between 27 and 280 GHz to achieve the sensitivity necessary to measure or constrain numerous cosmological parameters, including the tensor-to-scalar ratio, effective number of relativistic species, and sum of the neutrino masses. The SO scientific goals require coordination and control of the hardware distributed among the four telescopes on site. To meet this need, we have designed and built an open-sourced platform for distributed system management, called the Observatory Control System (ocs). This control system interfaces with all subsystems including the telescope control units, the microwave multiplexing readout electronics, and the cryogenic thermometry. We have also developed a system for live monitoring of housekeeping data and alerting, both of which are critical for remote observation. We take advantage of existing open source projects, such as crossbar for RPC and PubSub, twisted for asynchronous events, grafana for online remote monitoring, and docker for containerization. We provide an overview of the SO software and computer infrastructure, including the integration of SO-developed code with open source resources and lessons learned while testing at SO labs developing hardware systems as we prepare for deployment., 19 pages, 7 figures

The Simons Observatory (SO) is a cosmic microwave background (CMB) survey experiment with three small-aperture telescopes and one large-aperture telescope, which will observe from the Atacama Desert in Chile. In total, SO will field over 60,000 transition edge sensor (TES) bolometers in six spectral bands centered between 27 and 280 GHz in order to achieve the sensitivity necessary to measure or constrain numerous cosmological quantities, as outlined in The Simons Observatory Collaboration et al. (2019). To verify consistency of fabrication and performance in line with our sensitivity requirements, we will perform in-lab optical tests on isolated SO detectors as well as full detector arrays. The tests include beam measurements, bandpass measurements, and polarization measurements, among others. Here, we will describe the development of a cryogenic testbed that enables optical characterization of SO's detectors. We include the infrared filtering strategy to allow suitable cryogenic performance, design and implementation of the test equipment used in characterization, and the preliminary results from our validation of the testbed's cryo-optical performance.

The Simons Observatory (SO) will observe the cosmic microwave background (CMB) from Cerro Toco in the Atacama Desert of Chile. The observatory consists of three 0.5 m Small Aperture Telescopes (SATs) and one 6 m Large Aperture Telescope (LAT), covering six frequency bands centering around 30, 40, 90, 150, 230, and 280 GHz. The SO observations will transform the understanding of our universe by characterizing the properties of the early universe, measuring the number of relativistic species and the mass of neutrinos, improving our understanding of galaxy evolution, and constraining the properties of cosmic reionization. As a critical instrument, the Large Aperture Telescope Receiver (LATR) is designed to cool $\sim$ 60,000 transition-edge sensors (TES) to $, Comment: 20 pages, 12 figures, submitted to the 2020 SPIE Astronomical Telescopes + Instrumentation

The Simons Observatory (SO) is an upcoming cosmic microwave background (CMB) experiment located on Cerro Toco, Chile, that will map the microwave sky in temperature and polarization in six frequency bands spanning 27 to 285 GHz. SO will consist of one 6-m large aperture telescope fielding $$\sim$$ 30,000 detectors and an array of three 0.42-m small aperture telescopes (SATs) fielding an additional 30,000 detectors. This synergy will allow for the extremely sensitive characterization of the CMB over angular scales ranging from an arcmin to tens of degrees, enabling a wide range of scientific output. Here we focus on the SATs targeting degree angular scales with successive dichroic instruments observing at mid-frequency (MF: 93/145 GHz), ultra-high-frequency (UHF: 225/285 GHz), and low-frequency (LF: 27/39 GHz). The three SATs will be able to map $$\sim$$ 10% of the sky to a noise level of $$\sim$$ $$2\,\upmu {\hbox {K}}$$ -arcmin when combining 93 and 145 GHz. The multiple frequency bands will allow the CMB to be separated from galactic foregrounds (primarily synchrotron and dust), with the primary science goal of characterizing the primordial tensor-to-scalar ratio, r, at a target level of $$\sigma (r) \approx 0.003$$ .

We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey.

The Simons Observatory (SO) is a Cosmic Microwave Background (CMB) experiment to observe the microwave sky in six frequency bands from 30GHz to 290GHz. The Observatory -- at $\sim$5200m altitude -- comprises three Small Aperture Telescopes (SATs) and one Large Aperture Telescope (LAT) at the Atacama Desert, Chile. This research note describes the design and current status of the LAT along with its future timeline., 4 pages, 1 figure

The Earth's magnetic field induces Zeeman splitting of the magnetic dipole transitions of molecular oxygen in the atmosphere, which produces polarized emission in the millimeter-wave regime. This polarized emission is primarily circularly polarized and manifests as a foreground with a dipole-shaped sky pattern for polarization-sensitive ground-based cosmic microwave background experiments, such as the Cosmology Large Angular Scale Surveyor (CLASS), which is capable of measuring large angular scale circular polarization. Using atmospheric emission theory and radiative transfer formalisms, we model the expected amplitude and spatial distribution of this signal and evaluate the model for the CLASS observing site in the Atacama Desert of northern Chile. Then, using two years of observations at 32.3 GHz to 43.7 GHz from the CLASS Q-band telescope, we present a detection of this signal and compare the observed signal to that predicted by the model. We recover an angle between magnetic north and true north of $(-5.5 \pm 0.6)^\circ$, which is consistent with the expectation of $-5.9^\circ$ for the CLASS observing site. When comparing dipole sky patterns fit to both simulated and data-derived sky maps, the dipole directions match to within a degree, and the measured amplitudes match to within ${\sim}20\%$., Comment: 13 pages, 7 figures, published in ApJ

The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array that observes the cosmic microwave background (CMB) over 75% of the sky from the Atacama Desert, Chile, at frequency bands centered near 40, 90, 150, and 220 GHz. CLASS measures the large angular scale ($1^\circ\lesssim��\leqslant 90^\circ$) CMB polarization to constrain the tensor-to-scalar ratio at the $r\sim0.01$ level and the optical depth to last scattering to the sample variance limit. This paper presents the optical characterization of the 40 GHz telescope during its first observation era, from 2016 September to 2018 February. High signal-to-noise observations of the Moon establish the pointing and beam calibration. The telescope boresight pointing variation is $, 32 pages, 24 figures, published in ApJ

The Cosmology Large Angular Scale Surveyor consists of four instruments performing a CMB polarization survey. Currently, the 40 GHz and first 90 GHz instruments are deployed and observing, with the second 90 GHz and a multichroic 150/220 GHz instrument to follow. The receiver is a central component of each instrument's design and functionality. This paper describes the CLASS receiver design, using the first 90 GHz receiver as a primary reference. Cryogenic cooling and filters maintain a cold, low-noise environment for the detectors. We have achieved receiver detector temperatures below 50 mK in the 40 GHz instrument for 85% of the initial 1.5 years of operation, and observed in-band efficiency that is consistent with pre-deployment estimates. At 90 GHz, less than 26% of in-band power is lost to the filters and lenses in the receiver, allowing for high optical efficiency. We discuss the mounting scheme for the filters and lenses, the alignment of the cold optics and detectors, stray light control, and magnetic shielding., Fixed formatting of abstract; 20 Pages, 11 Figures, SPIE Conference Proceedings

The search for inflationary primordial gravitational waves and the measurement of the optical depth to reionization, both through their imprint on the large angular scale correlations in the polarization of the cosmic microwave background (CMB), has created the need for high sensitivity measurements of polarization across large fractions of the sky at millimeter wavelengths. These measurements are subject to instrumental and atmospheric 1=f noise, which has motivated the development of polarization modulators to facilitate the rejection of these large systematic effects. Variable-delay polarization modulators (VPMs) are used in the Cosmology Large Angular Scale Surveyor (CLASS) telescopes as the first element in the optical chain to rapidly modulate the incoming polarization. VPMs consist of a linearly polarizing wire grid in front of a movable flat mirror. Varying the distance between the grid and the mirror produces a changing phase shift between polarization states parallel and perpendicular to the grid which modulates Stokes U (linear polarization at 45°) and Stokes V (circular polarization). The CLASS telescopes have VPMs as the first optical element from the sky; this simultaneously allows a lock-in style polarization measurement and the separation of sky polarization from any instrumental polarization further along in the optical path. The CLASS VPM wire grids use 50 μm copper-plated tungsten wire with a 160μm spacing across a 60 cm clear aperture. The mirror is mounted on a flexure system with one degree of translational freedom, enabling the required mirror motion while maintaining excellent parallelism with respect to the wire grid. The wire grids and mirrors are held parallel to each other to better than 80 μm, and the wire grids have RMS flatness errors below 50 μm across the 60 cm aperture. The Q-band CLASS VPM was the first VPM to begin observing the CMB full time, starting in the Spring of 2016. The first W-band CLASS VPM was installed in the Spring of 2018.

The Cosmology Large Angular Scale Surveyor (CLASS) will measure the polarization of the Cosmic Microwave Background to search for and characterize the polarized signature of inflation. CLASS will operate from the Atacama Desert and observe $\sim$70% of the sky. A variable-delay polarization modulator (VPM) modulates the polarization at $\sim$10 Hz to suppress the 1/f noise of the atmosphere and enable the measurement of the large angular scale polarization modes. The measurement of the inflationary signal across angular scales that span both the recombination and reionization features allows a test of the predicted shape of the polarized angular power spectra in addition to a measurement of the energy scale of inflation. CLASS is an array of telescopes covering frequencies of 38, 93, 148, and 217 GHz. These frequencies straddle the foreground minimum and thus allow the extraction of foregrounds from the primordial signal. Each focal plane contains feedhorn-coupled transition-edge sensors that simultaneously detect two orthogonal linear polarizations. The use of single-crystal silicon as the dielectric for the on-chip transmission lines enables both high efficiency and uniformity in fabrication. Integrated band definition has been implemented that both controls the bandpass of the single mode transmission on the chip and prevents stray light from coupling to the detectors., Comment: 7 pages, 5 figures, accepted by the Journal of Low Temperature Physics

Exploring the everyday photographs of people offers new possibilities in anthropological research and focuses attention on a form of visual medium that is often taken for granted and glossed over in social research. By looking at the personal photographs of a Gujarati community in New Zealand, I discovered not only the importance of photographs in their lives but also the significant social relationships they have with them. For this community the most important photographs are their ancestral ones. Here I explore the affective, devotional and therapeutic nature of these images. I will discuss their elevated significance, darshanic qualities, and their ability to keep present deceased relatives in the respondents’ day-to-day lives. I make strong links with Barthes’ [1980] concept of punctum, and the therapeutic nature of vernacular photos as described in the discipline of phototherapy, and will extend the discussion on affective agency by suggesting that photographs in migrant communities do more than act...

We analyze simulated maps of the Cosmology Large Angular Scale Surveyor (CLASS) experiment and recover a nearly cosmic-variance limited estimate of the reionization optical depth $\tau$. We use a power spectrum-based likelihood to simultaneously clean foregrounds and estimate cosmological parameters in multipole space. Using software specifically designed to constrain $\tau$, the amplitude of scalar fluctuations $A_s$, and the tensor-to-scalar ratio $r$, we demonstrate that the CLASS experiment will be able to estimate $\tau$ within a factor of two of the full-sky cosmic variance limit allowed by cosmic microwave background polarization measurements. Additionally, we discuss the role of CLASS's $\tau$ constraint in conjunction with gravitational lensing of the CMB on obtaining a $\gtrsim4\sigma$ measurement of the sum of the neutrino masses., Comment: Accepted for publication by ApJ

The Cosmology Large Angular Scale Surveyor (CLASS) aims to detect and characterize the primordial B-mode signal and make a sample-variance-limited measurement of the optical depth to reionization. CLASS is a ground-based, multi-frequency microwave polarimeter that surveys 70% of the microwave sky every day from the Atacama Desert. The focal plane detector arrays of all CLASS telescopes contain smooth-walled feedhorns that couple to transition-edge sensor (TES) bolometers through symmetric planar orthomode transducer (OMT) antennas. These low noise polarization-sensitive detector arrays are fabricated on mono-crystalline silicon wafers to maintain TES uniformity and optimize optical efficiency throughout the wafer. In this paper, we discuss the design and characterization of the first CLASS 93 GHz detector array. We measure the dark parameters, bandpass, and noise spectra of the detectors and report that the detectors are photon-noise limited. With current array yield of 82%, we estimate the total array noise-equivalent power (NEP) to be 2.1 aW$\sqrt[]{\mathrm{s}}$., Comment: 16 pages, 9 figures

The Long-Term Oxygen Treatment Trial demonstrated that long-term supplemental oxygen did not reduce time to hospital admission or death for patients who have stable chronic obstructive pulmonary disease and resting and/or exercise-induced moderate oxyhemoglobin desaturation, nor did it provide benefit for any other outcome measured in the trial. Nine months after initiation of patient screening, after randomization of 34 patients to treatment, a trial design amendment broadened the eligible population, expanded the primary outcome, and reduced the goal sample size. Within a few years, the protocol underwent minor modifications, and a second trial design amendment lowered the required sample size because of lower than expected treatment group crossover rates. After 5.5 years of recruitment, the trial met its amended sample size goal, and 1 year later, it achieved its follow-up goal. The process of publishing the trial results brought renewed scrutiny of the study design and the amendments. This article expands on the previously published design and methods information, provides the rationale for the amendments, and gives insight into the investigators' decisions about trial conduct. The story of the Long-Term Oxygen Treatment Trial may assist investigators in future trials, especially those that seek to assess the efficacy and safety of long-term oxygen therapy. Clinical trial registered with clinicaltrials.gov (NCT00692198).

The Cosmology Large Angular Scale Surveyor (CLASS) is mapping the polarization of the Cosmic Microwave Background (CMB) at large angular scales ($2, Comment: 11 pages, 5 figures

The Cosmology Large Angular Scale Surveyor (CLASS) is a four telescope array designed to characterize relic primordial gravitational waves from inflation and the optical depth to reionization through a measurement of the polarized cosmic microwave background (CMB) on the largest angular scales. The frequencies of the four CLASS telescopes, one at 38 GHz, two at 93 GHz, and one dichroic system at 145/217 GHz, are chosen to avoid spectral regions of high atmospheric emission and span the minimum of the polarized Galactic foregrounds: synchrotron emission at lower frequencies and dust emission at higher frequencies. Low-noise transition edge sensor detectors and a rapid front-end polarization modulator provide a unique combination of high sensitivity, stability, and control of systematics. The CLASS site, at 5200 m in the Chilean Atacama desert, allows for daily mapping of up to 70\% of the sky and enables the characterization of CMB polarization at the largest angular scales. Using this combination of a broad frequency range, large sky coverage, control over systematics, and high sensitivity, CLASS will observe the reionization and recombination peaks of the CMB E- and B-mode power spectra. CLASS will make a cosmic variance limited measurement of the optical depth to reionization and will measure or place upper limits on the tensor-to-scalar ratio, $r$, down to a level of 0.01 (95\% C.L.).

Background Lung transplant recipients use a telemedicine device known as the electronic home spirometer to gauge the function of their lungs when they are away from the hospital or clinic setting. Health care providers review transmitted spirometry tests and user's symptom responses to detect early signs of infection and or rejection. Current home spirometry users have questions, concerns, and preferences about spirometry that may influence their daily adherence. A spirometer with two-way electronic messaging has the capability to deliver feedback messages to potentially address these questions and concerns. Objectives The purpose of this study was to identify the type of messaging content users prefer to receive and recognize as positively influencing their spirometry use. Methods The study design followed a qualitative approach investigating the experiences, perceptions, preferences, and realities of home spirometry. Three focus group sessions were used to generate opinions and interests about automatic messaging content. Results The focus group approach revealed the nature of six categories and five subcategories for feedback messaging content. These include education (general, lifestyle, and infection), goals, timing, technique, monitoring, and reminders (time sensitive, positive). Messages were created according to length, feasibility, past experience, and neutrality for electronic implementation. Conclusion The narrative content served as the primary source of electronic feedback messages. Actual quotes were used when applicable. It is believed that pertinent automated electronic feedback messages will enhance home spirometry connection, raise confidence in spirometry use, and influence daily adherence to the spirometry protocol. The content also serves as a foundation for establishing a plan of care individualized to each home spirometry user.