147 results on '"Kath, John"'
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2. Bayesian Learning of Gas Transport in Three-Dimensional Fracture Networks
3. Addressing quantum’s “fine print” with efficient state preparation and information extraction for quantum algorithms and geologic fracture networks
4. Reversible lysine-targeted probes reveal residence time-based kinase selectivity
5. Bayesian learning of gas transport in three-dimensional fracture networks
6. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes
7. Learning Gas Transport through Fracture Networks from Multi-Fidelity Data [Slides]
8. Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors
9. Data from Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
10. Supplementary Data from Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
11. Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
12. Proline-Rich Tyrosine Kinase 2 Regulates Osteoprogenitor Cells and Bone Formation, and Offers an Anabolic Treatment Approach for Osteoporosis
13. Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery
14. Explicit transient probabilities of various Markov models
15. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)
16. Daphniphyllum alkaloids, 16. Total synthesis of (+)-codaphniphylline
17. Chapter 18. T Lymphocyte Potassium Channel Blockers
18. Biomimetic total synthesis of methyl homosecodaphniphyllate: development of the tetracyclization reaction
19. A proposed biosynthesis of the pentacyclic skeleton: proto-daphniphylline
20. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)
21. Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
22. Selective addition of amines to 5-trifluoromethyl-2,4-dichloropyrimidine induced by Lewis acids
23. Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis
24. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
25. Abstract 2594: Characterization of a novel irreversible third generation EGFR TKI that targets T790M-mediated resistant EGFR-mutant NSCLC while sparing wild type EGFR
26. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
27. Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
28. Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
29. ChemInform Abstract: Selective Addition of Amines to 5‐Trifluoromethyl‐2,4‐dichloropyrimidine Induced by Lewis Acids.
30. Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition
31. Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation
32. Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)
33. Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays
34. 5-Bromo-3-(indan-1-yloxy)pyridin-2-amine
35. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
36. Abstract 753: Novel, potent and selective small molecule inhibitors of 3-phosphoinositide-dependent kinase (PDK1)
37. 5-Chloro-N-[2-(1H-imidazol-4-yl)ethyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
38. Abstract A86: Design, synthesis, and SAR of focal adhesion kinase (FAK) inhibitors
39. tert-Butyl 4-(1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxylate
40. Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
41. Discovery and Pharmacologic Characterization of CP-724,714, a Selective ErbB2 Tyrosine Kinase Inhibitor
42. Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor
43. Process Development of CP-481715, a Novel CCR1 Antagonist
44. Antiangiogenic and Antitumor Activity of a Selective PDGFR Tyrosine Kinase Inhibitor, CP-673,451
45. Potent Small Molecule CCR1 Antagonists.
46. The Discovery of Structurally Novel CCR1 Antagonists Derived from a Hydroxyethylene Peptide Isostere Template.
47. Novel CCR1 antagonists with improved metabolic stability
48. The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template
49. Potent small molecule CCR1 antagonists
50. CP-481,715, a Potent and Selective CCR1 Antagonist with Potential Therapeutic Implications for Inflammatory Diseases
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