Search

La Arteritis de Células Gigantes (ACG) es considerada uno de los síndromes vasculíticos más prevalentes. Afecta predominantemente a las arterias de mediano y gran calibre siendo la complicación más temida, una neuropatía óptica isquémica anterior que puede evolucionar a una pérdida irreversible de la visión. Los síntomas son causados por isquemia local debido al daño endovascular acompañado además de daño sistémico mediado por citoquinas. En los últimos años la ecografía doppler, la resonancia magnética y el PET scan fueron tomando importancia en la búsqueda de herramientas que puedan confirmar o excluir el diagnóstico de ACG sin embargo la biopsia de la arteria temporal (BAT) continúa siendo la prueba estándar para el diagnóstico de esta enfermedad.

El Escleredema de Buschke es una enfermedad poco común del tejido conectivo, de etiología desconocida que se caracteriza por el exceso de mucopolisacáridos ácidos en la dermis. Se describen tres tipos de acuerdo a su etiología. Clínicamente se caracteriza por induración cutánea simétrica que afecta en forma progresiva la región cervical, rostro, tórax, dorso y miembros, respetando manos y pies. El diagnóstico se basa en el cuadro clínico y los hallazgos histopatológicos característicos. No se ha establecido un tratamiento específico y efectivo, aunque se cita el uso de inmunosupresores, esteroides sistémicos y locales, así como fotoquimioterapia sistémica con psoralenos y radiación ultravioleta. En este artículo presentamos el caso de una mujer adulta con Escleredema de Buschke.

42. Enfermedad de hansen simulando colagenopatía Ma. Griselda Gómez, Lourdes González, Beatriz Di Martino1, Mirtha Rodríguez, Oilda Knopfelmacher, Lourdes Bolla 43. Encefalopatía reversible asociada a infusión de ciclofosfamida Alberto Moran, Carmen Montiel, David Morínigo, Justino Toledo, Julio Ávila, Margarita Duarte 44. Mano en garra como forma de presentación de la mucopolisacaridosis Tipo 1 Dora Montiel, Sandra Carolina Benítez, Rubén Darío Quintana, Verónica Raquel Benítez, Gustavo Javier Villar, Freddy Bruno, Laura Maciel 45. Autoinmunidad relacionada a citomegalovirus Patricia Melgarejo, Gabriela Ávila Pedretti, Sonia Cabrera-Villalba 45. Autoinmunidad relacionada a citomegalovirus Patricia Melgarejo, Gabriela Ávila Pedretti, Sonia Cabrera-Villalba 46. Mucopolisacaridosis Tipo I a propósito de un caso Victor Martínez, Marcos Vázquez, Nelson Ortiz, Isabel Acosta Colman, Rosa Ayala Lugo, Imelda Nuñez Martínez 47. Mujer con enfermedad de ehler-danlos tipo vascular Nelson Ortiz, Yanira Yinde, Jhonatan Losanto, Lourdes Román, Marcos Vázquez, Margarita Duarte 48. Oftalmoplejía por Granoulomatosis con Poliangeitis (GPA) Dardo Spessot, Sania Smolarczuk, Carmen Gaona, Lourdes Peñaflor 49. Osteopoiquilia de presentación atípica en una mujer con síndrome de superposición Jhonatan Losanto, Susan Riquelme, Lourdes Roman, Nelly Colman1, Margarita Duarte 50. Evolución de una paciente con eritema nodoso y compromiso pulmonar Karin Baumann, Marcos Vázquez, Victor Martínez, Nelson Ortiz, Isabel Acosta Colman, Margarita Duarte 51. Síndrome de löfgren, presentación aguda de sarcoidosis Dardo Spessot, Sania Smolarczuk, Carmen Gaona, Lourdes Peñaflor 52. Asociación rara de dos entidades poco frecuentes: síndrome de parry romber y enfermedades reumáticas. Presentación de 2 casos Jhonatan Losanto, Susan Riquelme, Karin Baumann, Yanira Yinde, Nelly Colman, Margarita Duarte 53. Vasculopatía de origen autoinmune Armando Mallorquín, Lilian Gómez, Mabel Villasanti, Ever Coronel, Iván Calderoli, Pedro Babak 54. Linfangioleiomiomatosis, en una paciente con diagnóstico de una vasculitis ANCA positiva Marcos Vázquez, Isabel Acosta Colman, Ana Soskin, R. Flor, Sonia Sanchez, Luis Montaner 55. Síndrome de cogan Dardo Spessot, Sania Smolarczuk, Carmen Gaona, Lourdes Peñaflor 56. Falla renal como presentación inicial de sindrome de goodpasture. A propósito de un caso Fernando Vittale, Johana Coronel, Elías Morán, Marcelo Garbett, Lorgia Avalos, Yanira Yinde 57. Paciente con dificultad progresiva para la marcha. presentación de un caso Susan Riquelme, Lourdes Román, Jhonatan Losanto, Yanira Yinde, Margarita Duarte 58. Enfermedad de Takayasu, descripción de 3 casos Marcos Vázquez, Carmen Montiel, Jhonatan Losanto, Liz Torres, Jhoana Coronel, Isabel Acosta Colman, Margarita Duarte

Milk thistle, Silybum marianum (L.) Gaertn. (Asteraceae), is an economically important medicinal plant utilized for silymarin production. Moreover, the species has been positively evaluated for vegetable oil and biomass production. Despite these positive characteristics, milk thistle is still marked by traits that are typical of undomesticated species (most importantly natural fruit dispersal at maturity) and requires further genetic improvement for its complete exploitation. This manuscript summarizes all the information collected through time about a collection of nine milk thistle wild and mutant lines and it discusses the possible further utilization of these genotypes. The accessions are characterized by interesting traits related to: fruit silymarin composition (S. marianum chemotype A and B), fruit fatty acid composition (high oleic and high stearic acid lines), fruit condensed tannins content, vegetative biomass composition (modification of xylans or lignin content), vegetative biomass structure (dwarf and tall lines), modifications of leaf variegation (hypervareigated line) and different types of fruit shatter resistance at maturity. All the lines underwent subsequent generations of selfing and are stable for all the described traits. The accessions will be made available at the Genebank of the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK, Gatersleben) and may prove to be a useful genetic material for the improvement of qualitative fruit traits (silymarin quality, fatty acid composition) and for the further development of shatter-resistant S. marianum genotypes towards the complete domestication of this promising species. [ABSTRACT FROM AUTHOR]

11. Conocimientos sobre lupus en estudiantes de medicina latinoamericanos Verónica Rose Marie Rotela Fisch, Celeste Valiente, Rebull, Elba Lorena Rosso Emperatriz, Miguel de Jesús Rosales Anthonnye, Rafael Lugo Álvaro 12. Enfermedades autoinmunes y dengue Dora Montiel, Estela Torres, Alba Aveiro, Gladys Alexis, Pineda1, Sandra Carolina Benítez, Liz Paola Martínez 13. Características demográficas y socioeconómicas de pacientes con lupus eritematoso sistémico y esclerosis sistémica Marcos Vázquez, Víctor Martínez, Nelson Ortiz, Jhonatan Losanto, Karim Bauman, Elias Rojas, Marcia Melo, Gabriela Ávila-Pedretti, Isabel Acosta, Colman, Margarita Duarte 14. Biomarcadores genéticos de susceptibilidad de padecer Lupus Eritematoso Sistémico en pacientes de origen paraguayo Marcos Vazquez, Ana Ayala Lugo, Valery Jolie, María Eugenia Acosta, Ivalena de Guillén, Jonathan Losanto, Elias Rojas, Nelson Ortiz, Victor Martínez, Karin Bauman, Marcia Melo, Sara Marsal, Antonio Julia, Margarita González,Hugo Torio, Margarita Duarte, Gabriela Ávila Pedretti, Isabel Acosta Colman, María Teresa Martínez 15. Estudio de la presencia del HPV con sus diferentes serotipos en pacientes con les y su asociación con factores de riesgos Susan Riquelme, Lourdes Román, María Eugenia Acosta, Isabel Acosta Colmán, Margarita Duarte, Gloria Colmán, Marcia Melo 16. Lupus eritematoso sistémico. Forma de presentación y caracterización clínica José Duarte, Rocío Falcón. Stefanía Montanaro1, Elías Morán1, Silvia González, Aldo Román, Sandra Samudio, Lorgia Ávalos, Nancy Candia, Silvio Espínola 17. Factores de riesgo cardiovascular en pacientes con LES Dora Montiel, Natalia González, Sandra Carolina Benítez, Gladys Alexis Pineda, Leily Rocio Colman, Gustavo Javier Villar Gustavo 18. Prevalencia de deficiencia de vitamina D en pacientes con lupus eritema toso sistémico y su asociación con la actividad de la enfermedad Nelson Ortiz, Lourdes Roman, Karin Baunman, María Eugenia Acosta, Gabriela Ávila Pedretti, Marcos Vazquez, Victor Martinez, Jhonatan Losanto, Marcia Melo, Margarita Duarte, María Teresa Martínez, Isabel Acosta Colman 19. Uso del rituximab en pacientes con lupus eritematoso sistemico Victor Martínez, Marcos Vázquez, Nelson Ortiz, Isabel Acosta Colman, Karin Baumann, Margarita Gonzalez, Marcia Melo, Margarita Duarte

1. Acontecimientos adversos en el registro de terapias biológicas BIOBADAGUAY Marco Franco, Patricia Melgarejo, Zoilo Morel, Juan Gabriel Elizaur, Pedro Delgadillo, Gabriela Ávila-Pedretti, Isabel Acosta Colman, Sonia Cabrera-Villalba, Jhonatan Losanto, Lourdes Román, Ernesto Paredes, Julio Mazzoleni, Paloma de Abreu 2. Artritis de reciente comienzo. ¿Cómo estamos a dos años del seguimiento? Pedro Delgadillo, Gabriela Ávila-Pedretti, Isabel Acosta Colman, Sonia Cabrera-Villalba2, Marco Franco, Patricia Melgarejo, Juan Gabriel Elizaur, Alicia Ramagli, Julio Mazzoleni, Paloma de Abreu 3. Remisión clínica en pacientes con artritis reumatoide establecida Lourdes Román, Susan Riquelme-Granada, Jhonatan Losanto, Ortiz Nelson, Margarita Duarte, Sonia Cabrera-Villalba 4. Existen diferencias y/o similitudes entre varones y mujeres con artritis reumatoide? Lourdes Román, Elias Rojas, Susan Riquelme, Jhonatan Losanto, Gabriela Ávila-Pedretti, Aldo Ojeda, Yanira Yinde, Sonia Cabrera-Villalba, Margarita Duarte 5. Calidad de vida en pacientes con artritis reumatoide establecida medida por el SF36 Lourdes Román, Elías Rojas, Susan Riquelme, Jhonatan Losanto1, Gabriela Ávila-Pedretti, Aldo Ojeda, Yanira Yinde, Sonia Cabrera-Villalba, Margarita Duarte 6. Características clínico-epidemiológicas y comorbilidades en una cohorte de pacientes con artritis reumatoide Jhonatan Losanto, Susan Riquelme-Granada, Lourdes Román, Karin Baumann, Elías Rojas, Sonia Cabrera-Villalba, Margarita Duarte 7. Estudio multicéntrico: características clínicas y epidemiológicas de pacientes con espondiloatritis en dos hospitales de alta complejidad de Gran Asunción Jhonatan Losanto, Pedro Delgadillo, Susan Riquelme, Lourdes Román, Pedro Babak, Nelly Colman, Gabriela Ávila-Pedretti2, Aldo Ojeda, Marcos Vázquez, Julio Mazzoleni, Yanira Yinde, Margarita Duarte 8. Valoración del riesgo cardiovascular en la cohorte PANLAR de artritis de reciente comienzo de Paraguay. Seguimiento de 24 meses Juan Gabriel Elizaur, Patricia Melgarejo, Isabel Acosta Colman, Marco Franco, Pedro Delgadillo, Gabriela Ávila Pedretti, Sonia Cabrera Villalba, Alicia Ramagli, Julio Mazzoleni, Paloma de Abreu 9. Supervivencia de la terapia biológica en pacientes con artritis reumatoide Patricia Melgarejo, Gabriela Ávila-Pedretti, Paloma de Abreu, Julio Mazzoleni, Clarisse Díaz, Marta Ferreira 10. Supervivencia de las terapias biológicas en el registro BIOBADAGUAY Patricia Melgarejo, Marco Franco, Zoilo Morel, Juan Gabriel Elizaur, Pedro Delgadillo, Gabriela Ávila- Pedretti, Isabel Acosta Colman, Sonia Cabrera-Villalba, Jhonatan Losanto, Lourdes Román, Ernesto Paredes, Julio Mazzoleni, Paloma de Abreu

The article discusses the practice of witchcraft and beliefs in superstition and the First Commandment during the late Middle Ages. It tackles the development of the concept of diabolical witchcraft discussed in the 1988 article "Moral Arithmetic: Seven Deadly Sins Into Ten Commandments," by John Bossy, the treatment of idolatry as the primary Christian moral offense in the 16th century, and the changes brought by the adoption of Decalogue morality.

20. Prevalencia de deficiencia e insuficiencia de vitamina D y factores asociados en estudiantes universitarios que viven en asunción Marcos Vázquez, Isabel Acosta Colman, Gabriela Ávila-Pedretti, Nelly Colmán, Sonia Cabrera-Villalba, Aldo Ojeda, Yanira Yinde, Jhonatan Losanto, Elias Rojas, Susan Riquelme, Lourdes Roman, Karin Baumann, Alicia Aquino, Marcia Melo, María Teresa Martinez, Margarita Duarte

The article discusses the concepts of women, men, and love magic in late medieval English pastoral manuals. According to the author, historians working on ecclesiastical writing argue that many medieval churchmen viewed erotic magic as a female activity. The author adds that studies of the inquisition and witch trial records point out that women were more likely to be put on trial for using love magic than men.

The article focuses on the underlying religious authoritative concern over superstition in the late Middle Ages in Europe. It explores developments in late medieval religious and intellectual culture, causing authorities to focus their concern on lay appropriations of ecclesiastical prayers, rites and blessings. It implies that the nature of spiritual being combined with certain intellectual developments and the growth of specific intellectual structures in the early 15th century will caused religious authorities to examine common beliefs and practices more closely than had previously been the case. Roman authorities had coined the term "superstitio" in anquity and had used it to describe excessive forms of divination, as well as the actions of suspicious foreign cults.

Reactive oxygen species (ROS) and endothelin-1 (ET-1) contribute to vascular pathophysiology in obesity. In this context, whether ET-1 modulates hydroxyl radical (.OH) formation and the function of ROS/·OH in obesity is not known. In the present study, formation and function of ROS, including ·OH, were investigated in the aorta of lean and leptin-deficient obese ob/ob mice. Hydroxyl radical formation was detected ex vivo using terephthalic acid in intact aortic rings and the involvement of ROS in ET-1-mediated vasoreactivity was analyzed using the antioxidant EPC-K1, a combination of α-tocopherol and ascorbic acid. Generation of either ·OH, ·O2-, and H2O2 was strongly inhibited by EPC-K1 (all P < 0.05). In obese mice, basal vascular ·OH formation and ROS activity were reduced by 3-fold and 5-fold, respectively (P < 0.05 vs. lean). ET-1 markedly enhanced ·OH formation in lean (6-fold, P < 0.05 vs. untreated) but not in obese mice. Obesity increased ET-1-induced contractions (P < 0.05 vs. lean), and ROS scavenging further enhanced the response (P < 0.05 vs. untreated). Exogenous ROS, including ·OH caused stronger vasodilation in obese animals (P < 0.05 vs. lean), whereas endothelium-dependent relaxation was similar between lean and obese animals. In conclusion, we present a sensitive method allowing ex vivo measurement of vascular ·OH generation and provide evidence that ET-1 regulates vascular ·OH formation. The data indicate that in obesity, vascular formation of ROS, including ·OH is lower, whereas the sensitivity to ROS is increased, suggesting a novel and important role of ROS, including ·OH in the regulation of vascular tone in disease status associated with increased body weight. [ABSTRACT FROM AUTHOR]

AIMS: To assess the performance of 2-sucrose-phosphate based transport medium (2-SP) for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae by an automated commercial polymerase chain reaction (PCR) and ligase chain reaction (LCR) compared to centrifugation culture on McCoy cells for C trachomatis. Second, to compare both amplification systems for initial diagnostic testing of a low prevalence population for sexually transmitted diseases. METHODS: Four hundred and eighty one consecutive urogenital and conjunctival specimens were examined. All tests were performed on the same specimen collected with a dacron swab and transported in 2-SP medium. Samples that were positive by culture or by both PCR and LCR were considered to be true positives. RESULTS: The prevalences of C trachomatis and of N gonorrhoeae were 2.7% and 0.4%, respectively. PCR had a resolved sensitivity and specificity of 100% and 99.8%, respectively, for C trachomatis, and 100% and 98.9%, respectively, for N gonorrhoeae. LCR was 100% sensitive and specific for both pathogens. The resolved sensitivity of the shell vial assay was 85%. No culture positive sample would have been missed by PCR or LCR. The inhibition rate for PCR was 4.8%. CONCLUSIONS: 2-SP medium proved to be suitable for both PCR and LCR. It is not limited to any one test manufacturer and allows the performance of amplification techniques and viral and chlamydia culture from the same specimen. The LCR was more reliable than PCR on initial testing. However, hands on time is longer, and no amplification control is available for LCR. [ABSTRACT FROM PUBLISHER]

Enteroviruses affect millions of people worldwide and are of significant clinical importance. The standard method for enterovirus identification and genotyping still relies on Sanger sequencing of short diagnostic amplicons. In this study, we assessed the feasibility of nanopore sequencing using the new flow cell "Flongle" for fast, cost-effective, and accurate genotyping of human enteroviruses from clinical samples. PCR amplification of partial VP1 gene was performed from multiple patient samples, which were multiplexed together after barcoding PCR and sequenced multiple times on Flongle flow cells. The nanopore consensus sequences obtained from mapping reads to a reference database were compared to their Sanger sequence counterparts. Using clinical specimens sampled over different years, we were able to correctly identify enterovirus species and genotypes for all tested samples, even when doubling the number of barcoded samples on one flow cell. Average sequence identity across sequencing runs was >99.7%. Phylogenetic analysis showed that the consensus sequences achieved with Flongle delivered accurate genotyping. We conclude that the new Flongle-based assay with its fast turnover time, low cost investment, and low cost per sample represents an accurate, reproducible, and cost-effective platform for enterovirus identification and genotyping. [ABSTRACT FROM AUTHOR]