1. Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
- Author
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Brian C. Coe, Geert Mayer, Wolfgang H. Oertel, Felix P. Bernhard, Donald C. Brien, Julia E. Perkins, David Vadasz, Jeff Huang, Douglas P. Munoz, Karén Wilhelm, and Annette Janzen
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Movement disorders ,Parkinson's disease ,genetic structures ,Rapid eye movement sleep ,REM Sleep Behavior Disorder ,Regular Issue Articles ,Audiology ,Pupil ,03 medical and health sciences ,Behavior disorder ,0302 clinical medicine ,Saccades ,Humans ,Medicine ,eye movement ,business.industry ,Brief Report ,Brain ,Eye movement ,Parkinson Disease ,medicine.disease ,Saccadic masking ,030104 developmental biology ,Neurology ,Saccade ,biomarker ,Brief Reports ,Neurology (clinical) ,medicine.symptom ,business ,prodromal Parkinson's disease ,030217 neurology & neurosurgery - Abstract
Background Parkinson's disease (PD) patients exhibit deficits in saccade performance, pupil function, and blink rate. Isolated REM (rapid eye movement) Sleep Behavior Disorder (RBD) is a harbinger to PD making them candidates to investigate for early oculomotor abnormalities as PD biomarkers. Objectives We tested whether saccade, pupillary, and blink responses in RBD were similar to PD. Methods RBD (n = 22), PD (n = 22) patients, and healthy controls (CTRL) (n = 74) were studied with video-based eye-tracking. Results RBD patients did not have significantly different saccadic behavior compared to CTRL, but PD patients differed from CTRL and RBD. Both patient groups had significantly lower blink rates, dampened pupil constriction, and dilation responses compared to CTRL. Conclusion RBD and PD patients had altered pupil and blink behavior compared to CTRL. Because RBD saccade parameters were comparable to CTRL, pupil and blink brain areas may be impacted before saccadic control areas, making them potential prodromal PD biomarkers. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
- Published
- 2021