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Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
- Source :
- Movement Disorders
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background Parkinson's disease (PD) patients exhibit deficits in saccade performance, pupil function, and blink rate. Isolated REM (rapid eye movement) Sleep Behavior Disorder (RBD) is a harbinger to PD making them candidates to investigate for early oculomotor abnormalities as PD biomarkers. Objectives We tested whether saccade, pupillary, and blink responses in RBD were similar to PD. Methods RBD (n = 22), PD (n = 22) patients, and healthy controls (CTRL) (n = 74) were studied with video-based eye-tracking. Results RBD patients did not have significantly different saccadic behavior compared to CTRL, but PD patients differed from CTRL and RBD. Both patient groups had significantly lower blink rates, dampened pupil constriction, and dilation responses compared to CTRL. Conclusion RBD and PD patients had altered pupil and blink behavior compared to CTRL. Because RBD saccade parameters were comparable to CTRL, pupil and blink brain areas may be impacted before saccadic control areas, making them potential prodromal PD biomarkers. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Movement disorders
Parkinson's disease
genetic structures
Rapid eye movement sleep
REM Sleep Behavior Disorder
Regular Issue Articles
Audiology
Pupil
03 medical and health sciences
Behavior disorder
0302 clinical medicine
Saccades
Humans
Medicine
eye movement
business.industry
Brief Report
Brain
Eye movement
Parkinson Disease
medicine.disease
Saccadic masking
030104 developmental biology
Neurology
Saccade
biomarker
Brief Reports
Neurology (clinical)
medicine.symptom
business
prodromal Parkinson's disease
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15318257 and 08853185
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Movement Disorders
- Accession number :
- edsair.doi.dedup.....919b01b3629e14e5cca6de87fd2dd101