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2. In SituHeparan Sulfate-Induced Peptide Self-Assembly to Overcome the Cell Surface Glycocalyx Barrier for Cancer Treatment

Author

Pei, Pengfei, Chen, Long, Guan, Xinyao, Wei, Peng, Kang, Xiaoxu, Gong, Lili, Liu, Lihong, Guo, Wenxu, Gu, Renji, Wang, Lixin, Zhao, Chuanke, Liang, Jun F., and Luo, Shi-Zhong

Abstract

Heparan sulfate (HS) is a major component of cell surface glycocalyx with extensive negative charges and plays a protective role by preventing toxins, including small molecule drugs and anticancer cationic lytic peptides (ACLPs), from cells. However, this effect may compromise the treatment efficiency of anticancer drugs. To overcome the impedance of cancer cell glycocalyx, an HS-targeting ACLP PTP-7z was designed by fusion of an ACLP and a Zn2+-binding HS-targeting peptide. Upon Zn2+ion binding, PTP-7z could self-assemble into uniform nanoparticles and show improved serum stability and reduced hemolysis, which enable it to self-deliver to tumor sites. The peptide PTP-7z showed a pH- and Zn2+ion-dependent HS-binding ability, which triggers the HS-induced in situself-assembling on the cancer cell surface in the acidic tumor microenvironment (TME). The self-assembled PTP-7z can overcome the impedance of cell glycocalyx by either disrupting cell membranes or translocating into cells through endocytosis and inducing cell apoptosis. Moreover, PTP-7z can also inhibit cancer cell migration. These results proved that HS-responsive in situself-assembling is a practical strategy to overcome the cancer cell glycocalyx barrier for ACLPs and could be extended to the design of other peptide drugs to promote their in vivoapplication.

Published
2024
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7. Poly(d-amino acid) Nanoparticles Target StaphylococcalGrowth and Biofilm Disassembly by Interfering with Peptidoglycan Synthesis

Author

Feng, Wenli, Chittò, Marco, Xie, Wensheng, Ren, Qun, Liu, Fang, Kang, Xiaoxu, Zhao, Dongdong, Li, Guofeng, Moriarty, Thomas Fintan, and Wang, Xing

Abstract

d-Amino acids are signals for biofilm disassembly. However, unexpected metabolic pathways severely attenuate the utilization of d-amino acids in biofilm disassembly, resulting in unsatisfactory efficiency. Herein, three-dimensional poly(d-amino acid) nanoparticles (NPs), which possess the ability to block intracellular metabolism, are constructed with the aim of disassembling the biofilms. The obtained poly(α-N-acryloyl-d-phenylalanine)-block-poly(β-N-acryloyl-d-aminoalanine NPs (denoted as FA NPs) present α-amino groups and α-carboxyl groups of d-aminoalanine on their surface, which guarantees that FA NPs can effectively insert into bacterial peptidoglycan (PG) via the mediation of PG binding protein 4 (PBP4). Subsequently, the FA NPs trigger the detachment of amyloid-like fibers that connect to the PG and reduce the number of polysaccharides and proteins in extracellular polymeric substances (EPS). Finally, FA NPs damage the structural stability of EPS and lead to the disassembly of the biofilm. Based on this feature, FA NPs significantly enhance the killing efficacy of encapsulated sitafloxacin sesquihydrate (Sita) by facilitating the penetration of Sita within the biofilm, achieving complete elimination of Staphylococcalbiofilm in mice. Therefore, this study strongly demonstrates that FA NPs can effectively improve biofilm disassembly efficacy and provide great potential for bacterial biofilm infection treatment.

Published
2024
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9. GSH/pH Cascade-Responsive Nanoparticles Eliminate Methicillin-Resistant Staphylococcus aureusBiofilm via Synergistic Photo-Chemo Therapy

Author

Kang, Xiaoxu, Yang, Xuankun, Bu, Fanqiang, Feng, Wenli, Liu, Fang, Xie, Wensheng, Li, Guofeng, and Wang, Xing

Abstract

Bacterial biofilm infection threatens public health, and efficient treatment strategies are urgently required. Phototherapy is a potential candidate, but it is limited because of the off-targeting property, vulnerable activity, and normal tissue damage. Herein, cascade-responsive nanoparticles (NPs) with a synergistic effect of phototherapy and chemotherapy are proposed for targeted elimination of biofilms. The NPs are fabricated by encapsulating IR780 in a polycarbonate-based polymer that contains disulfide bonds in the main chain and a Schiff-base bond connecting vancomycin (Van) pendants in the side chain (denoted as SP–Van@IR780 NPs). SP–Van@IR780 NPs specifically target bacterial biofilms in vitroand in vivoby the mediation of Van pendants. Subsequently, SP–Van@IR780 NPs are decomposed into small size and achieve deep biofilm penetration due to the cleavage of disulfide bonds in the presence of GSH. Thereafter, Van is then detached from the NPs because the Schiff base bonds are broken at low pH when SP@IR780 NPs penetrate into the interior of biofilm. The released Van and IR780 exhibit a robust synergistic effect of chemotherapy and phototherapy, strongly eliminate the biofilm both in vitroand in vivo. Therefore, these biocompatible SP–Van@IR780 NPs provide a new outlook for the therapy of bacterial biofilm infection.

Published
2024
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10. Large-Scale Fabrication of SiC-TiC@C Powders via Modified Molten Salt Shielding Synthesis Technique and Their Effect on the Properties of Al 2 O 3 -MgO Castables.

Author

Li, Yong, Yin, Yicheng, Chen, Jing, Kang, Xiaoxu, Kang, Shihao, Ma, Haoxuan, Zhang, Shaowei, and Jia, Quanli

Subjects
FUSED salts, ALUMINUM oxide, POWDERS, THERMAL shock, RAW materials
Abstract

Graphite flakes are commonly used to fabricate carbon-based refractories owing to their superior properties, including better corrosion resistance and thermal shock resistance (TSR); unfortunately, their insufficient water-wettability has remarkably hindered their application in castables. Aiming to enhance their water-wettability, a facile and low-cost technique for fabricating carbides coated in graphite was proposed in this work. Firstly, SiC-TiC coated graphite (SiC-TiC@C) powders were prepared via modified molten salt shielding synthesis in an air atmosphere using graphite flake, Si and Ti powders as raw materials and NaCl-KCl as the molten salt shielding medium. Water-wettability and oxidation resistance of SiC-TiC@C powders were significantly improved. Compared to the Al2O3-MgO castables with graphite flakes, the water demand of the castables with SiC-TiC@C was noticeably decreased from 6.85% to 4.89%, thereby decreasing the apparent porosity of the castables with 5% SiC-TiC@C (from 20.3% to 13%), enhancing the cold strength, hot strength and oxidation resistance of the castables. Such enhancements are ascribed to continuous and crack-free SiC-TiC coatings on graphite surfaces ensuring that the castables have outstanding properties. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Decoding Cognitive States from Neural Activities of Somatosensory Cortex

Author

Kang, Xiaoxu, Schieber, Marc, Thakor, Nitish V., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Huang, Tingwen, editor, Zeng, Zhigang, editor, Li, Chuandong, editor, and Leung, Chi Sing, editor

Published
2012
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18. 300 MM Wafer Laser Anneal Process Development for Applications of Multiple Process Condition in Different Zones on Single Wafer

Author

Kang, Xiaoxu, primary, Huang, Yuanhao, additional, Luo, Wen, additional, Liu, Jianrui, additional, Chu, Zhenghui, additional, Zhong, Xiaolan, additional, Zhang, Min, additional, Zhou, Xiaoqiang, additional, Zang, Kaiyan, additional, Li, Ming, additional, Zhu, Limin, additional, Lu, Hanwei, additional, and Zhang, Bo, additional

Published
2022
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19. Degradable Pseudo Conjugated Polymer Nanoparticles with NIR‐II Photothermal Effect and Cationic Quaternary Phosphonium Structural Bacteriostasis for Anti‐Infection Therapy

Author

Zhou, Huiling, primary, Tang, Dongsheng, additional, Kang, Xiaoxu, additional, Yuan, Haitao, additional, Yu, Yingjie, additional, Xiong, Xiaolu, additional, Wu, Nier, additional, Chen, Fangzhou, additional, Wang, Xing, additional, Xiao, Haihua, additional, and Zhou, Dongsheng, additional

Published
2022
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21. Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

Author

Fuyi Wang, Yao Zhao, Yingjie Yu, Qin-Pei Wu, Jifu Hao, Xue-Qin Hou, Zhang Jimei, Xing-Jie Liang, Yuxuan Zhang, Baochang Zhao, Yongchao Wang, Yongxiang Zhao, Lingpu Zhang, Binglong Li, Guanghua Rong, Haihua Xiao, Kang Xiaoxu, Yuhua Weng, Dengshuai Wei, Shizhu Chen, and Yufei Wang

Subjects
General Physics and Astronomy, Antineoplastic Agents, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, DNA Adducts, chemistry.chemical_compound, medicine, Humans, General Materials Science, Cisplatin, General Engineering, DNA, Hyperthermia, Induced, Glutathione, Prodrug, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Cross-Linking Reagents, chemistry, Mechanism of action, Cancer cell, Biophysics, Click chemistry, medicine.symptom, 0210 nano-technology, Intracellular, medicine.drug
Abstract

DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few DNA adducts (

Published
2020

28. A negatively charged Pt(<scp>iv</scp>) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance

Author

Yixin Wu, Dengshuai Wei, Yao Zhao, Fuyi Wang, Chen Zhigang, Yingjie Yu, Haihua Xiao, and Kang Xiaoxu

Subjects
chemistry.chemical_classification, Chemistry, Cisplatin resistance, Biomedical Engineering, Nanoparticle, 02 engineering and technology, General Chemistry, General Medicine, Polymer, Prodrug, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Hydrophilic polymers, General Materials Science, 0210 nano-technology
Abstract

A negatively charged Pt(iv) prodrug with lipid tails can self-assemble into nanoparticles via electrostatic complexation with a positively charged hydrophilic polymer, which exhibits great potential for clinical application.

Published
2019

29. Characterization of Ferroelectric Al 0.7 Sc 0.3 N Thin Film on Pt and Mo Electrodes.

Author

Nie, Ran, Shao, Shuai, Luo, Zhifang, Kang, Xiaoxu, and Wu, Tao

Subjects
THIN films, STRAY currents, FERROELECTRICITY, SHAPE memory alloys, ELECTRODES, METALLIC surfaces, LEAD titanate
Abstract

In the past decade, aluminum scandium nitride (AlScN) with a high Sc content has shown ferroelectric properties, which provides a new option for CMOS-process-compatible ferroelectric memory, sensors and actuators, as well as tunable devices. In this paper, the ferroelectric properties of A l 0.7 S c 0.3 N grown on different metals were studied. The effect of metal and abnormal orientation grains (AOGs) on ferroelectric properties was observed. A coercive field of approximately 3 MV/cm and a large remanent polarization of more than 100 μC/cm2 were exhibited on the Pt surface. The A l 0.7 S c 0.3 N thin film grown on the Mo metal surface exhibited a large leakage current. We analyzed the leakage current of A l 0.7 S c 0.3 N during polarization with the polarization frequency, and found that the A l 0.7 S c 0.3 N films grown on either Pt or Mo surfaces have large leakage currents at frequencies below 5 kHz. The leakage current decreases significantly as the frequency approaches 10 kHz. The positive up negative down (PUND) measurement was used to obtain the remanent polarization of the films, and it was found that the remanent polarization values were not the same in the positive and negative directions, indicating that the electrode material has an effect on the ferroelectric properties. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Multiscale entropy analysis of EEG for assessment of post-cardiac arrest neurological recovery under hypothermia in rats

Author

Kang, Xiaoxu, Jia, Xiaofeng, Geocadin, Romergryko G., Thakor, Nitish V., and Maybhate, Anil

Subjects
Electroencephalography -- Methods, Cardiac arrest -- Complications and side effects, Entropy (Physics) -- Observations, Hypothermia -- Diagnosis, Nervous system diseases -- Diagnosis, Biological sciences, Business, Computers, Health care industry
Abstract

Neurological complications after cardiac arrest (CA) can be fatal. Although hypothermia has been shown to be beneficial, understanding the mechanism and establishing neurological outcomes remains challenging because effects of CA and hypothermia are not well characterized. This paper aims to analyze EEG (and the [alpha]-rhythms) using multiscale entropy (MSE) to demonstrate the ability of MSE in tracking changes due to hypothermia and compare MSE during early recovery with long-term neurological examinations. Ten Wistar rats, upon post-CA resuscitation, were randomly subjected to hypothermia (32[degrees]C-34 [degrees]C, N = 5) or normothermia (36.5 [degrees]C-37.5 [degrees]C, N = 5). EEG was recorded and analyzed using MSE during seven recovery phases for each experiment: baseline, CA, and tire early recovery phases (R1-R5). Postresuscitation neurological examination was performed at 6, 24, 48, and 72 h to obtain neurological deficit scores (NDSs). Results showed MSE to be a sensitive marker of changes in [alpha]-rhythms. Significant difference (p < 0.05) was found between the MSE for two groups during recovery, suggesting that MSE can successfully reflect temperature modulation. A comparison of short-term MSE and long-term NDS suggested that MSE could be used for predicting favorability of long-term outcome. These experiments point to the role of cortical rhythms in reporting early neurological response to ischemia and therapeutic hypothermia. Index Terms--Cardiac arrest (CA), entropy, neurological injury, quantitative EEG.

Published
2009

33. 多层压电驱动器在光刻机中的应用

Author

杜刚 Du Gang, 康晓旭 Kang Xiaoxu, 曾江涛 Zeng Jiangtao, and 曾涛 Zeng Tao

Subjects
Electrical and Electronic Engineering, Atomic and Molecular Physics, and Optics
Published
2022

34. Correction to Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

Author

Zhang, Jimei, primary, Zhao, Baochang, additional, Chen, Shizhu, additional, Wang, Yongchao, additional, Zhang, Yuxuan, additional, Wang, Yufei, additional, Wei, Dengshuai, additional, Zhang, Lingpu, additional, Rong, Guanghua, additional, Weng, Yuhua, additional, Hao, Jifu, additional, Li, Binglong, additional, Hou, Xue-Qin, additional, Kang, Xiaoxu, additional, Zhao, Yao, additional, Wang, Fuyi, additional, Zhao, Yongxiang, additional, Yu, Yingjie, additional, Wu, Qin-Pei, additional, Liang, Xing-Jie, additional, and Xiao, Haihua, additional

Published
2020
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35. Optimization of Ion Implanter Hardware for Metal Contamination Reduction

Author

Kang, Xiaoxu, primary, Xie, Junyu, additional, Tian, Long, additional, Chen, Zhangfa, additional, He, Dong, additional, Sheng, Xiaoyu, additional, Zhou, Xiaoqiang, additional, Shen, Ruoxi, additional, Zhong, Xiaolan, additional, Chen, Shoumian, additional, Zhao, Yuhang, additional, Hua, Guangping, additional, Zhu, Limin, additional, Lu, Hanwei, additional, Xu, Yun, additional, and Zhang, Bo, additional

Published
2020
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39. Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

Author

Zhang, Jimei, primary, Zhao, Baochang, additional, Chen, Shizhu, additional, Wang, Yongchao, additional, Zhang, Yuxuan, additional, Wang, Yufei, additional, Wei, Dengshuai, additional, Zhang, Lingpu, additional, Rong, Guanghua, additional, Weng, Yuhua, additional, Hao, Jifu, additional, Li, Binglong, additional, Hou, Xue-Qin, additional, Kang, Xiaoxu, additional, Zhao, Yao, additional, Wang, Fuyi, additional, Zhao, Yongxiang, additional, Yu, Yingjie, additional, Wu, Qin-Pei, additional, Liang, Xing-Jie, additional, and Xiao, Haihua, additional

Published
2020
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43. A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species

Author

Yixin Wu, Shihou Sheng, Shiguo Chen, Zhigang Chen, Xuefeng Wang, Haihua Xiao, Kang Xiaoxu, and Xuzi Cai

Subjects
Reactive oxygen species metabolism, Iron, Nanoparticle, Artesunate, Antineoplastic Agents, Mitochondrion, 010402 general chemistry, 01 natural sciences, Catalysis, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, Microscopy, Electron, Transmission, Materials Chemistry, Inhibitory concentration 50, Prodrugs, chemistry.chemical_classification, Membrane Potential, Mitochondrial, Reactive oxygen species, 010405 organic chemistry, Chemistry, Cell Cycle, Metals and Alloys, General Chemistry, Prodrug, Combinatorial chemistry, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Mitochondria, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Ceramics and Composites, Reactive Oxygen Species, Hydrophobic and Hydrophilic Interactions
Abstract

An artesunate anticancer prodrug with a long aliphatic chain N,N′-bis(dodecyl)-l-glutamic diamide was developed for nanoparticle via iron-mediated ROS generation.

Published
2019

47. MEMS micro-bridge structure-based process platform fabricated with CMOS Al BEOL compatible process

Author

Kang, Xiaoxu, primary, Zhong, Xiaolan, additional, Shen, Ruoxi, additional, Zuo, Qingyun, additional, Li, Ming, additional, Chen, Shoumian, additional, Zhao, Yuhang, additional, Zhu, Xingwang, additional, Zhu, Limin, additional, Liu, Shanshan, additional, Wang, Jianmin, additional, Lu, Hanwei, additional, Wang, Wei, additional, Ye, Zijing, additional, Wang, Jianpeng, additional, and Zhang, Bo, additional

Published
2019
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