Search

Your search keyword '"Kamlin OF"' showing total 767 results
Start Over Author "Kamlin OF"
767 results on '"Kamlin OF"'

2. Non-ceruloplasmin copper and urinary copper in clinically stable Wilson disease: Alignment with recommended targets

Author

Peter Ott, Thomas Sandahl, Aftab Ala, David Cassiman, Eduardo Couchonnal-Bedoya, Rubens Gisbert Cury, Anna Czlonkowska, Gerald Denk, Renata D’Inca, Francisco de Assis Aquino Gondim, Joanna Moore, Aurelia Poujois, Carlos Alexandre Twardowschy, Karl Heinz Weiss, Massimo Zuin, C.Omar F. Kamlin, and Michael L. Schilsky

Subjects
Exchangeable copper, bioavailable copper, free serum copper, protein speciation, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background & Aims: Wilson disease (WD) is caused by accumulation of copper primarily in the liver and brain. During maintenance therapy of WD with D-penicillamine, current guidelines recommend on-treatment ranges of urinary copper excretion (UCE) of 200-500 μg/24 h and serum non-ceruloplasmin-bound copper (NCC) of 50-150 μg/L. We compared NCC (measured by two novel assays) and UCE from patients with clinically stable WD on D-penicillamine therapy with these recommendations. Methods: This is a secondary analysis of data from the Chelate trial (NCT03539952) that enrolled physician-selected patients with clinically stable WD on D-penicillamine maintenance therapy (at an unaltered dose for at least 4 months). We analyzed laboratory samples from the first screening visit, prior to interventions. NCC was measured by either protein speciation (NCC-Sp) using anion exchange high-performance liquid chromatography protein speciation followed by copper determination with inductively coupled plasma mass spectroscopy or as exchangeable copper (NCC-Ex). NCC-Sp was also analyzed in healthy controls (n = 75). Results: In 76 patients with WD with 21.3±14.3 average treatment-years, NCC-Sp (mean±SD: 56.6±26.2 μg/L) and NCC-Ex (mean±SD: 57.9±24.7 μg/L) were within the 50-150 μg/L target in 61% and 54% of patients, respectively. In addition, 36% and 31%, respectively, were even below the normal ranges (NCC-Sp: 46-213 μg/L, NCC-Ex: 41-71 μg/L). NCC-Ex positively correlated with NCC-Sp (r2 = 0.66, p

Published
2024
Full Text
View/download PDF

3. Non-ceruloplasmin copper and urinary copper in clinically stable Wilson disease: Alignment with recommended targets

Author

Ott, Peter, Sandahl, Thomas, Ala, Aftab, Cassiman, David, Couchonnal-Bedoya, Eduardo, Cury, Rubens Gisbert, Czlonkowska, Anna, Denk, Gerald, D’Inca, Renata, de Assis Aquino Gondim, Francisco, Moore, Joanna, Poujois, Aurelia, Twardowschy, Carlos Alexandre, Weiss, Karl Heinz, Zuin, Massimo, Kamlin, C.Omar F., and Schilsky, Michael L.

Published
2024
Full Text
View/download PDF

5. Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: study protocol for the international, multicenter, randomized PLUSS trial

Author

Manley, Brett J., Kamlin, C. Omar F., Donath, Susan, Huang, Li, Birch, Pita, Cheong, Jeanie L. Y., Dargaville, Peter A., Dawson, Jennifer A., Doyle, Lex W., Jacobs, Susan E., Wilson, Rodney, Davis, Peter G., and McKinlay, Christopher J. D.

Published
2023
Full Text
View/download PDF

6. Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: statistical analysis plan for the international, multicenter, randomized PLUSS trial

Author

Kate L Francis, Christopher J D McKinlay, C Omar F Kamlin, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Peter G Davis, Susan M Donath, and Brett J Manley

Subjects
Medicine (General), R5-920
Abstract

Abstract Background Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks’ gestation and is associated with an increased risk of adverse neurodevelopmental and respiratory outcomes in childhood. Effective and safe prophylactic therapies for BPD are urgently required. Systemic corticosteroids reduce rates of BPD in the short term but are associated with poorer neurodevelopmental outcomes if given to ventilated infants in the first week after birth. Intratracheal administration of corticosteroid admixed with exogenous surfactant could overcome these concerns by minimizing systemic sequelae. Several small, randomized trials have found intratracheal budesonide in a surfactant vehicle to be a promising therapy to increase survival free of BPD. The primary objective of the PLUSS trial is to determine whether intratracheal budesonide mixed with surfactant increases survival free of bronchopulmonary dysplasia (BPD) at 36 weeks’ postmenstrual age (PMA) in extremely preterm infants born before 28 weeks’ gestation. Methods An international, multicenter, double-blinded, randomized trial of intratracheal budesonide (a corticosteroid) mixed with surfactant for extremely preterm infants to increase survival free of BPD at 36 weeks’ postmenstrual age (PMA; primary outcome). Extremely preterm infants aged

Published
2023
Full Text
View/download PDF

7. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Barcala-Furelos, Roberto, Beerman, Stephen B., Bruckner, Marlies, Castrén, Maaret, Chong, ShuLing, Claesson, Andreas, Dunne, Cody L., Finan, Emer, Fukuda, Tatsuma, Lalgudi Ganesan, Saptharishi, Gately, Callum, Gois, Aecio, Gray, Seth, Halamek, Louis P., Hoover, Amber V., Hurst, Cameron, Josephsen, Justin, Kollander, Louise, Omar Kamlin, C., Kool, Mirjam, Li, Lei, Mecrow, Thomas S., Montgomery, William, Ristau, Patrick, Jayashree, Muralidharan, Schmidt, Andrew, Scquizzato, Tommaso, Seesink, Jeroen, Sempsrott, Justin, Lee Solevåg, Anne, Strand, Marya L., Szpilman, David, Szyld, Edgardo, Thom, Ogilvie, Tobin, Joshua M., Trang, Jacinta, Webber, Jonathon, Webster, Hannah K., Wellsford, Michelle, Berg, Katherine M., Bray, Janet E., Ng, Kee-Chong, Liley, Helen G., Greif, Robert, Carlson, Jestin N., Morley, Peter T., Drennan, Ian R., Smyth, Michael, Scholefield, Barnaby R., Weiner, Gary M., Cheng, Adam, Djärv, Therese, Abelairas-Gómez, Cristian, Acworth, Jason, Andersen, Lars W., Atkins, Dianne L., Berry, David C., Bhanji, Farhan, Bierens, Joost, Bittencourt Couto, Thomaz, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Breckwoldt, Jan, Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Dassanayake, Vihara, Davis, Peter G., Dawson, Jennifer A., Fernanda de Almeida, Maria, De Caen, Allan R., Deakin, Charles D., Dicker, Bridget, Douma, Matthew J., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Fijacko, Nino, Finn, Judith C., Flores, Gustavo E., Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hatanaka, Tetsuo, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Daripa Kawakami, Mandira, Kim, Han-Suk, Kleinman, Monica E., Kloeck, David A., Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun, Lockey, Andrew S., Macneil, Finlay, Maconochie, Ian K., John Madar, R., Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Monnelly, Vix, Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., Ohshimo, Shinchiro, Olasveengen, Theresa M., Gene Ong, Yong-Kwang, Orkin, Aaron M., Parr, Michael J., Patocka, Catherine, Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Raitt, James, Ramachandran, Shalini, Ramaswamy, Viraraghavan V., Raymond, Tia T., Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Singletary, Eunice M., Skrifvars, Markus B., Smith, Christopher M., Soar, Jasmeet, Stassen, Willem, Sugiura, Takahiro, Tijssen, Janice A., Topjian, Alexis A., Trevisanuto, Daniele, Vaillancourt, Christian, Wyckoff, Myra H., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M., Zideman, David A., and Nolan, Jerry P.

Published
2024
Full Text
View/download PDF

8. Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: study protocol for the international, multicenter, randomized PLUSS trial

Author

Brett J. Manley, C. Omar F. Kamlin, Susan Donath, Li Huang, Pita Birch, Jeanie L. Y. Cheong, Peter A. Dargaville, Jennifer A. Dawson, Lex W. Doyle, Susan E. Jacobs, Rodney Wilson, Peter G. Davis, and Christopher J. D. McKinlay

Subjects
Infant, Extremely preterm, Bronchopulmonary dysplasia, Respiratory distress syndrome, Neonatal intensive care, Pulmonary surfactant, Medicine (General), R5-920
Abstract

Abstract Background Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks’ gestation and is associated with an increased risk of adverse neurodevelopmental and respiratory outcomes in childhood. Effective and safe prophylactic therapies for BPD are urgently required. Systemic corticosteroids reduce rates of BPD in the short-term but are associated with poorer neurodevelopmental outcomes if given to ventilated infants in the first week after birth. Intratracheal administration of corticosteroid admixed with exogenous surfactant could overcome these concerns by minimizing systemic sequelae. Several small, randomized trials have found intratracheal budesonide in a surfactant vehicle to be a promising therapy to increase survival free of BPD. Methods An international, multicenter, double-blinded, randomized trial of intratracheal budesonide (a corticosteroid) mixed with surfactant for extremely preterm infants to increase survival free of BPD at 36 weeks’ postmenstrual age (PMA; primary outcome). Extremely preterm infants aged

Published
2023
Full Text
View/download PDF

9. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Berg, Katherine M., Bray, Janet E., Ng, Kee-Chong, Liley, Helen G., Greif, Robert, Carlson, Jestin N., Morley, Peter T., Drennan, Ian R., Smyth, Michael, Scholefield, Barnaby R., Weiner, Gary M., Cheng, Adam, Djärv, Therese, Abelairas-Gómez, Cristian, Acworth, Jason, Andersen, Lars W., Atkins, Dianne L., Berry, David C., Bhanji, Farhan, Bierens, Joost, Bittencourt Couto, Thomaz, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Breckwoldt, Jan, Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Dassanayake, Vihara, Davis, Peter G., Dawson, Jennifer A., de Almeida, Maria Fernanda, De Caen, Allan R., Deakin, Charles D., Dicker, Bridget, Douma, Matthew J., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Fijacko, Nino, Finn, Judith C., Flores, Gustavo E., Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hatanaka, Tetsuo, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica E., Kloeck, David A., Ko, Ying-Chih, Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun, Lockey, Andrew S., Macneil, Finlay, Maconochie, Ian K., Madar, R. John, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Monnelly, Vix, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., Ohshimo, Shinchiro, Olasveengen, Theresa M., Ong, Yong-Kwang Gene, Orkin, Aaron M., Parr, Michael J., Patocka, Catherine, Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Raitt, James, Ramachandran, Shalini, Ramaswamy, Viraraghavan V., Raymond, Tia T., Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Singletary, Eunice M., Skrifvars, Markus B., Smith, Christopher M., Soar, Jasmeet, Stassen, Willem, Sugiura, Takahiro, Tijssen, Janice A., Topjian, Alexis A., Trevisanuto, Daniele, Vaillancourt, Christian, Wyckoff, Myra H., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M., Zideman, David A., Nolan, Jerry P., Barcala-Furelos, Roberto, Beerman, Stephen B., Castrén, Maaret, Chong, ShuLing, Claesson, Andreas, Dunne, Cody L., Ersdal, Hege L., Finan, Emer, Fuerch, Janene, Fukuda, Tatsuma, Ganesan, Saptharishi Lalgudi, Gately, Callum, Gray, Seth, Halamek, Louis P., Hoover, Amber V., Kollander, Louise, Kamlin, C. Omar, Koo, Mirjam, Li, Lei, Leone, Tina A., Mecrow, s, Montgomery, William, Ristau, Patrick, Jayashree, Muralidharan, Quek, Bin Huey, Schmidt, Andrew, Scquizzato, Tommaso, Seesink, Jeroen, Sempsrott, Justin, Shah, Birju A., Strand, Marya L., Szpilman, David, Szyld, Edgardo, Thio, Marta, Thom, Ogilvie, Tobin, Joshua M., Udaeta, Enrique, Webber, Jonathon, Webster, Hannah K., Wellsford, Michelle, and Yamada, Nicole K.

Published
2023
Full Text
View/download PDF

12. Tidal volumes during delivery room stabilization of (near) term infants

Author

Janine Thomann, Christoph M. Rüegger, Vincent D. Gaertner, Eoin O’Currain, Omar F. Kamlin, Peter G. Davis, and Laila Springer

Subjects
Term and late preterm infants, Delivery room stabilization, Positive pressure ventilation, Tidal volume, Pediatrics, RJ1-570
Abstract

Abstract Background We sought to assess tidal volumes in (near) term infants during delivery room stabilization. Methods Secondary analysis of a prospective study comparing two facemasks used for positive pressure ventilation (PPV) in newborn infants ≥ 34 weeks gestation. PPV was provided with a T-piece device with a PIP of 30 cmH2O and positive end-expiratory airway pressure of 5 cmH2O. Expired tidal volumes (Vt) were measured with a respiratory function monitor. Target range for Vt was defined to be 4 – 8 ml/kg. Results Twenty-three infants with a median (IQR) gestational age of 38.1 (36.4 – 39.0) weeks received 1828 inflations with a median Vt of 4.6 (3.3 – 6.2) ml/kg. Median Vt was in the target range in 12 infants (52%), lower in 9 (39%) and higher in 2 (9%). Thirty-six (25—27) % of the inflations were in the target rage over the duration of PPV while 42 (25 – 65) % and 10 (3 – 33) % were above and below target range. Conclusions Variability of expiratory tidal volume delivered to term and late preterm infants was wide. Reliance on standard pressures and clinical signs may be insufficient to provide safe and effective ventilation in the delivery room. Trial registration This is a secondary analysis of a prospectively registered randomized controlled trial (ACTRN12616000768493).

Published
2022
Full Text
View/download PDF

14. Corrigendum to “2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces” [Resuscitation 181 (2022) 208–288]

Author

Wyckoff, Myra H., primary, Greif, Robert, additional, Morley, Peter T., additional, Ng, Kee-Chong, additional, Olasveengen, Theresa M., additional, Singletary, Eunice M., additional, Soar, Jasmeet, additional, Cheng, Adam, additional, Drennan, Ian R., additional, Liley, Helen G., additional, Scholefield, Barnaby R., additional, Smyth, Michael A., additional, Welsford, Michelle, additional, Zideman, David A., additional, Acworth, Jason, additional, Aickin, Richard, additional, Andersen, Lars W., additional, Atkins, Diane, additional, Berry, David C., additional, Bhanji, Farhan, additional, Bierens, Joost, additional, Borra, Vere, additional, Böttiger, Bernd W., additional, Bradley, Richard N., additional, Bray, Janet E., additional, Breckwoldt, Jan, additional, Callaway, Clifton W., additional, Carlson, Jestin N., additional, Cassan, Pascal, additional, Castrén, Maaret, additional, Chang, Wei-Tien, additional, Charlton, Nathan P., additional, Chung, Sung Phil, additional, Considine, Julie, additional, Costa-Nobre, Daniela T., additional, Couper, Keith, additional, Couto, Thomaz Bittencourt, additional, Dainty, Katie N., additional, Davis, Peter G., additional, de Almeida, Maria Fernanda, additional, de Caen, Allan R., additional, Deakin, Charles D., additional, Djärv, Therese, additional, Donnino, Michael W., additional, Douma, Matthew J., additional, Duff, Jonathan P., additional, Dunne, Cody L., additional, Eastwood, Kathryn, additional, El-Naggar, Walid, additional, Fabres, Jorge G., additional, Fawke, Joe, additional, Finn, Judith, additional, Foglia, Elizabeth E., additional, Folke, Fredrik, additional, Gilfoyle, Elaine, additional, Goolsby, Craig A., additional, Granfeldt, Asger, additional, Guerguerian, Anne-Marie, additional, Guinsburg, Ruth, additional, Hirsch, Karen G., additional, Holmberg, Mathias J., additional, Hosono, Shigeharu, additional, Hsieh, Ming-Ju, additional, Hsu, Cindy H., additional, Ikeyama, Takanari, additional, Isayama, Tetsuya, additional, Johnson, Nicholas J., additional, Kapadia, Vishal S., additional, Daripa Kawakami, Mandira, additional, Kim, Han-Suk, additional, Kleinman, Monica, additional, Kloeck, David A., additional, Kudenchuk, Peter J., additional, Lagina, Anthony T., additional, Lauridsen, Kasper G., additional, Lavonas, Eric J., additional, Lee, Henry C., additional, (Jeffrey) Lin, Yiqun, additional, Lockey, Andrew S., additional, Maconochie, Ian K., additional, John Madar, R., additional, Hansen, Carolina Malta, additional, Masterson, Siobhan, additional, Matsuyama, Tasuku, additional, McKinlay, Christopher J.D., additional, Meyran, Daniel, additional, Morgan, Patrick, additional, Morrison, Laurie J., additional, Nadkarni, Vinay, additional, Nakwa, Firdose L., additional, Nation, Kevin J., additional, Nehme, Ziad, additional, Nemeth, Michael, additional, Neumar, Robert W., additional, Nicholson, Tonia, additional, Nikolaou, Nikolaos, additional, Nishiyama, Chika, additional, Norii, Tatsuya, additional, Nuthall, Gabrielle A., additional, O'Neill, Brian J., additional, Gene Ong, Yong-Kwang, additional, Orkin, Aaron M., additional, Paiva, Edison F., additional, Parr, Michael J., additional, Patocka, Catherine, additional, Pellegrino, Jeffrey L., additional, Perkins, Gavin D., additional, Perlman, Jeffrey M., additional, Rabi, Yacov, additional, Reis, Amelia G., additional, Reynolds, Joshua C., additional, Ristagno, Giuseppe, additional, Rodriguez-Nunez, Antonio, additional, Roehr, Charles C., additional, Rüdiger, Mario, additional, Sakamoto, Tetsuya, additional, Sandroni, Claudio, additional, Sawyer, Taylor L., additional, Schexnayder, Steve M., additional, Schmölzer, Georg M., additional, Schnaubelt, Sebastian, additional, Semeraro, Federico, additional, Skrifvars, Markus B., additional, Smith, Christopher M., additional, Sugiura, Takahiro, additional, Tijssen, Janice A., additional, Trevisanuto, Daniele, additional, Van de Voorde, Patrick, additional, Wang, Tzong-Luen, additional, Weiner, Gary M., additional, Wyllie, Jonathan P., additional, Yang, Chih-Wei, additional, Yeung, Joyce, additional, Nolan, Jerry P., additional, Berg, Katherine M., additional, Burdick, Madeline C., additional, Cartledge, Susie, additional, Dawson, Jennifer A., additional, Elgohary, Moustafa M., additional, Ersdal, Hege L., additional, Finan, Emer, additional, Flaatten, Hilde I., additional, Flores, Gustavo E., additional, Fuerch, Janene, additional, Garg, Rakesh, additional, Gately, Callum, additional, Goh, Mark, additional, Halamek, Louis P., additional, Handley, Anthony J., additional, Hatanaka, Tetsuo, additional, Hoover, Amber, additional, Issa, Mohmoud, additional, Johnson, Samantha, additional, Kamlin, C. Omar, additional, Ko, Ying-Chih, additional, Kule, Amy, additional, Leone, Tina A., additional, MacKenzie, Ella, additional, Macneil, Finlay, additional, Montgomery, William, additional, O'Dochartaigh, Domhnall, additional, Ohshimo, Shinichiro, additional, Palazzo, Francesco Stefano, additional, Picard, Christopher, additional, Quek, Bin Huey, additional, Raitt, James, additional, Ramaswamy, Viraraghavan V., additional, Scapigliati, Andrea, additional, Shah, Birju A., additional, Stewart, Craig, additional, Strand, Marya L., additional, Szyld, Edgardo, additional, Thio, Marta, additional, Topjian, Alexis A., additional, Udaeta, Enrique, additional, Vaillancourt, Christian, additional, Wetsch, Wolfgang A., additional, Wigginton, Jane, additional, Yamada, Nicole K., additional, Yao, Sarah, additional, Zace, Drieda, additional, and Zelop, Carolyn M., additional

Published
2024
Full Text
View/download PDF

15. 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Burdick, Madeline C., Cartledge, Susie, Dawson, Jennifer A., Elgohary, Moustafa M., Ersdal, Hege L., Finan, Emer, Flaatten, Hilde I., Flores, Gustavo E., Fuerch, Janene, Garg, Rakesh, Gately, Callum, Goh, Mark, Halamek, Louis P., Handley, Anthony J., Hatanaka, Tetsuo, Hoover, Amber, Issa, Mohmoud, Johnson, Samantha, Kamlin, C. Omar, Ko, Ying-Chih, Kule, Amy, Leone, Tina A., MacKenzie, Ella, Macneil, Finlay, Montgomery, William, O’Dochartaigh, Domhnall, Ohshimo, Shinichiro, Stefano Palazzo, Francesco, Picard, Christopher, Quek, Bin Huey, Raitt, James, Ramaswamy, Viraraghavan V., Scapigliati, Andrea, Shah, Birju A., Stewart, Craig, Strand, Marya L., Szyld, Edgardo, Thio, Marta, Topjian, Alexis A., Udaeta, Enrique, Vaillancourt, Christian, Wetsch, Wolfgang A., Wigginton, Jane, Yamada, Nicole K., Yao, Sarah, Zace, Drieda, Zelop, Carolyn M., Wyckoff, Myra H., Greif, Robert, Morley, Peter T., Ng, Kee-Chong, Olasveengen, Theresa M., Singletary, Eunice M., Soar, Jasmeet, Cheng, Adam, Drennan, Ian R., Liley, Helen G., Scholefield, Barnaby R., Smyth, Michael A., Welsford, Michelle, Zideman, David A., Acworth, Jason, Aickin, Richard, Andersen, Lars W., Atkins, Diane, Berry, David C., Bhanji, Farhan, Bierens, Joost, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Bray, Janet E., Breckwoldt, Jan, Callaway, Clifton W., Carlson, Jestin N., Cassan, Pascal, Castrén, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Phil Chung, Sung, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Couto, Thomaz Bittencourt, Dainty, Katie N., Davis, Peter G., de Almeida, Maria Fernanda, de Caen, Allan R., Deakin, Charles D., Djärv, Therese, Donnino, Michael W., Douma, Matthew J., Duff, Jonathan P., Dunne, Cody L., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Finn, Judith, Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun (Jeffrey), Lockey, Andrew S., Maconochie, Ian K., Madar, R. John, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Morgan, Patrick, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., O’Neill, Brian J., Gene Ong, Yong-Kwang, Orkin, Aaron M., Paiva, Edison F., Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Sugiura, Takahiro, Tijssen, Janice A., Trevisanuto, Daniele, Van de Voorde, Patrick, Wang, Tzong-Luen, Weiner, Gary M., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Nolan, Jerry P., and Berg, Katherine M.

Published
2022
Full Text
View/download PDF

16. Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial

Author

To, Uyen, Patel, Amar, Hettiarachchi, Daksshi, Giorgini, Alessia, Monico, Sara, Litwin, Tomasz, Piechal, Agnieszka, Skowronska, Marta, Lachaux, Alain, Belmalih, Abdelouahed, Boogers, Alexandra, Mohr, Isabelle, Langel, Andrea, Freitas, Christian, Barbosa, Egberto Reis, Sandahl, Thomas D, Gerdes, Lisbet, Obadia, Alexandre, Rahli, Djamila, Cosgrove, Jeremy, Schilsky, Michael L, Czlonkowska, Anna, Zuin, Massimo, Cassiman, David, Twardowschy, Carlos, Poujois, Aurelia, Gondim, Francisco de Assis A, Denk, Gerald, Cury, Rubens G, Ott, Peter, Moore, Joanna, Ala, Aftab, D'Inca, Renata, Couchonnal-Bedoya, Eduardo, D'Hollander, Koenraad, Dubois, Nicolas, Kamlin, C Omar F, and Weiss, Karl Heinz

Published
2022
Full Text
View/download PDF

19. 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Wyckoff, Myra H., Greif, Robert, Morley, Peter T., Ng, Kee-Chong, Olasveengen, Theresa M., Singletary, Eunice M., Soar, Jasmeet, Cheng, Adam, Drennan, Ian R., Liley, Helen G., Scholefield, Barnaby R., Smyth, Michael A., Welsford, Michelle, Zideman, David A., Acworth, Jason, Aickin, Richard, Andersen, Lars W., Atkins, Diane, Berry, David C., Bhanji, Farhan, Bierens, Joost, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Bray, Janet E., Breckwoldt, Jan, Callaway, Clifton W., Carlson, Jestin N., Cassan, Pascal, Castrén, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Couto, Thomaz Bittencourt, Dainty, Katie N., Davis, Peter G., de Almeida, Maria Fernanda, de Caen, Allan R., Deakin, Charles D., Djärv, Therese, Donnino, Michael W., Douma, Matthew J., Duff, Jonathan P., Dunne, Cody L., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Finn, Judith, Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun (Jeffrey), Lockey, Andrew S., Maconochie, Ian K., Madar, R. John, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Morgan, Patrick, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., O’Neill, Brian J., Ong, Yong-Kwang Gene, Orkin, Aaron M., Paiva, Edison F., Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Sugiura, Takahiro, Tijssen, Janice A., Trevisanuto, Daniele, Van de Voorde, Patrick, Wang, Tzong-Luen, Weiner, Gary M., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Nolan, Jerry P., Berg, Katherine M., Burdick, Madeline C., Cartledge, Susie, Dawson, Jennifer A., Elgohary, Moustafa M., Ersdal, Hege L., Finan, Emer, Flaatten, Hilde I., Flores, Gustavo E., Fuerch, Janene, Garg, Rakesh, Gately, Callum, Goh, Mark, Halamek, Louis P., Handley, Anthony J., Hatanaka, Tetsuo, Hoover, Amber, Issa, Mohmoud, Johnson, Samantha, Kamlin, C. Omar, Ko, Ying-Chih, Kule, Amy, Leone, Tina A., MacKenzie, Ella, Macneil, Finlay, Montgomery, William, O’Dochartaigh, Domhnall, Ohshimo, Shinichiro, Palazzo, Francesco Stefano, Picard, Christopher, Quek, Bin Huey, Raitt, James, Ramaswamy, Viraraghavan V., Scapigliati, Andrea, Shah, Birju A., Stewart, Craig, Strand, Marya L., Szyld, Edgardo, Thio, Marta, Topjian, Alexis A., Udaeta, Enrique, Vaillancourt, Christian, Wetsch, Wolfgang A., Wigginton, Jane, Yamada, Nicole K., Yao, Sarah, Zace, Drieda, and Zelop, Carolyn M.

Published
2022
Full Text
View/download PDF

21. Establishing a Novel Diagnostic Framework Using Handheld Point-of-Care Focused-Echocardiography (HoPE) for Acute Left-Sided Cardiac Valve Emergencies: A Bayesian Approach for Emergency Physicians in Resource-Limited Settings

Author

Kamlin Ekambaram and Karim Hassan

Subjects
point-of-care echocardiography, handheld point-of-care ultrasound, acute valvular emergencies, acute severe aortic regurgitation, acute severe mitral regurgitation, resource-limited settings, Medicine (General), R5-920
Abstract

Acute severe cardiac valve emergencies, such as acute severe mitral regurgitation (AMR) and acute severe aortic regurgitation (AAR), present significant challenges in terms of diagnosis and management. Handheld point-of-care ultrasound devices have emerged as potentially pivotal tools in ensuring the prompt and accurate diagnosis of these left-sided valve emergencies by emergency physicians, particularly in resource-limited settings. Despite the increased utilisation of point-of-care ultrasound by emergency physicians for the management of patients in states of acute cardiorespiratory failure, current diagnostic protocols cannot perform sufficient quantitative assessments of the left-sided cardiac valves. This review elucidates and evaluates the diagnostic utility of handheld point-of-care focused-echocardiography (HoPE) in native AMR and AAR by reviewing the relevant literature and the use of clinical case examples from the Emergency Department at Port Shepstone Regional Hospital (PSRH-ED)—a rural, resource-limited hospital located in KwaZulu-Natal, South Africa. Combining the findings of the review and clinical case illustrations, this review proceeds to synthesise a novel, Bayesian-inspired, iterative diagnostic framework that integrates HoPE into the evaluation of patients with acute cardiorespiratory failure and suspected severe left-sided valve lesions.

Published
2023
Full Text
View/download PDF

25. Physiologically based cord clamping for infants ≥32+0 weeks gestation: A randomised clinical trial and reference percentiles for heart rate and oxygen saturation for infants ≥35+0 weeks gestation.

Author

Shiraz Badurdeen, Peter G Davis, Stuart B Hooper, Susan Donath, Georgia A Santomartino, Alissa Heng, Diana Zannino, Monsurul Hoq, C Omar F Kamlin, Stefan C Kane, Anthony Woodward, Calum T Roberts, Graeme R Polglase, Douglas A Blank, and Baby Directed Umbilical Cord Clamping (BabyDUCC) collaborative group

Subjects
Medicine
Abstract

BackgroundGlobally, the majority of newborns requiring resuscitation at birth are full term or late-preterm infants. These infants typically have their umbilical cord clamped early (ECC) before moving to a resuscitation platform, losing the potential support of the placental circulation. Physiologically based cord clamping (PBCC) is clamping the umbilical cord after establishing lung aeration and holds promise as a readily available means of improving early newborn outcomes. In mechanically ventilated lambs, PBCC improved cardiovascular stability and reduced hypoxia. We hypothesised that PBCC compared to ECC would result in higher heart rate (HR) in infants needing resuscitation, without compromising safety.Methods and findingsBetween 4 July 2018 and 18 May 2021, infants born at ≥32+0 weeks' gestation with a paediatrician called to attend were enrolled in a parallel-arm randomised trial at 2 Australian perinatal centres. Following initial stimulation, infants requiring further resuscitation were randomised within 60 seconds of birth using a smartphone-accessible web link. The intervention (PBCC) was to establish lung aeration, either via positive pressure ventilation (PPV) or effective spontaneous breathing, prior to cord clamping. The comparator was early cord clamping (ECC) prior to resuscitation. The primary outcome was mean HR between 60 to 120 seconds after birth, measured using 3-lead electrocardiogram, extracted from video recordings blinded to group allocation. Nonrandomised infants had deferred cord clamping (DCC) ≥120 seconds in the observational study arm. Among 508 at-risk infants enrolled, 123 were randomised (n = 63 to PBCC, n = 60 to ECC). Median (interquartile range, IQR) for gestational age was 39.9 (38.3 to 40.7) weeks in PBCC infants and 39.6 (38.4 to 40.4) weeks in ECC infants. Approximately 49% and 50% of the PBCC and ECC infants were female, respectively. Five infants (PBCC = 2, ECC = 3, 4% total) had missing primary outcome data. Cord clamping occurred at a median (IQR) of 136 (126 to 150) seconds in the PBCC arm and 37 (27 to 51) seconds in the ECC arm. Mean HR between 60 to 120 seconds after birth was 154 bpm (beats per minute) for PBCC versus 158 bpm for ECC (adjusted mean difference -6 bpm, 95% confidence interval (CI) -17 to 5 bpm, P = 0.39). Among 31 secondary outcomes, postpartum haemorrhage ≥500 ml occurred in 34% and 32% of mothers in the PBCC and ECC arms, respectively. Two hundred ninety-five nonrandomised infants (55% female) with median (IQR) gestational age of 39.6 (38.6 to 40.6) weeks received DCC. Data from these infants was used to create percentile charts of expected HR and oxygen saturation in vigorous infants receiving DCC. The trial was limited by the small number of infants requiring prolonged or advanced resuscitation. PBCC may provide other important benefits we did not measure, including improved maternal-infant bonding and higher iron stores.ConclusionsIn this study, we observed that PBCC resulted in similar mean HR compared to infants receiving ECC. The findings suggest that for infants ≥32+0 weeks' gestation who receive brief, effective resuscitation at closely monitored births, PBCC does not provide additional benefit over ECC (performed after initial drying and stimulation) in terms of key physiological markers of transition. PBCC was feasible using a simple, low-cost strategy at both cesarean and vaginal births. The percentile charts of HR and oxygen saturation may guide clinicians monitoring the transition of at-risk infants who receive DCC.Trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12618000621213.

Published
2022
Full Text
View/download PDF

26. Effect of Minimally Invasive Surfactant Therapy Versus Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome The OPTIMIST: A Randomized Clinical Trial

Author

Dargaville, P.A., Kamlin, O.F., Orsini, F., Wang, X., De Paoli, A.G., Kanmaz Kutman, H.G., Cetinkaya, M., Aiyappan, A., Lemyre, B., Kuo, S., Rajadurai, V.S., O’Shea, J., Biniwale, M., Ramanathan, R., Kushnir, A., Bader, D., Thomas, M.R., Mallinath, C., Buksh, M.J., Bhatia, R., Sullivan, C.L., Shinwell, E.S., Dyson, A., Barker, D.P., Kugelman, A., Donovan, T.J., Tauscher, M.K., Murthy, V., Ali, S.K.M., Yossuck, P., Clark, H.W., Soll, R.F., Carlin, J.B., and Davis, P.G.

Published
2022
Full Text
View/download PDF

27. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Berg, Katherine M., primary, Bray, Janet E., additional, Ng, Kee-Chong, additional, Liley, Helen G., additional, Greif, Robert, additional, Carlson, Jestin N., additional, Morley, Peter T., additional, Drennan, Ian R., additional, Smyth, Michael, additional, Scholefield, Barnaby R., additional, Weiner, Gary M., additional, Cheng, Adam, additional, Djärv, Therese, additional, Abelairas-Gómez, Cristian, additional, Acworth, Jason, additional, Andersen, Lars W., additional, Atkins, Dianne L., additional, Berry, David C., additional, Bhanji, Farhan, additional, Bierens, Joost, additional, Bittencourt Couto, Thomaz, additional, Borra, Vere, additional, Böttiger, Bernd W., additional, Bradley, Richard N., additional, Breckwoldt, Jan, additional, Cassan, Pascal, additional, Chang, Wei-Tien, additional, Charlton, Nathan P., additional, Chung, Sung Phil, additional, Considine, Julie, additional, Costa-Nobre, Daniela T., additional, Couper, Keith, additional, Dainty, Katie N., additional, Dassanayake, Vihara, additional, Davis, Peter G., additional, Dawson, Jennifer A., additional, Fernanda de Almeida, Maria, additional, De Caen, Allan R., additional, Deakin, Charles D., additional, Dicker, Bridget, additional, Douma, Matthew J., additional, Eastwood, Kathryn, additional, El-Naggar, Walid, additional, Fabres, Jorge G., additional, Fawke, Joe, additional, Fijacko, Nino, additional, Finn, Judith C., additional, Flores, Gustavo E., additional, Foglia, Elizabeth E., additional, Folke, Fredrik, additional, Gilfoyle, Elaine, additional, Goolsby, Craig A., additional, Granfeldt, Asger, additional, Guerguerian, Anne-Marie, additional, Guinsburg, Ruth, additional, Hatanaka, Tetsuo, additional, Hirsch, Karen G., additional, Holmberg, Mathias J., additional, Hosono, Shigeharu, additional, Hsieh, Ming-Ju, additional, Hsu, Cindy H., additional, Ikeyama, Takanari, additional, Isayama, Tetsuya, additional, Johnson, Nicholas J., additional, Kapadia, Vishal S., additional, Daripa Kawakami, Mandira, additional, Kim, Han-Suk, additional, Kleinman, Monica E., additional, Kloeck, David A., additional, Kudenchuk, Peter, additional, Kule, Amy, additional, Kurosawa, Hiroshi, additional, Lagina, Anthony T., additional, Lauridsen, Kasper G., additional, Lavonas, Eric J., additional, Lee, Henry C., additional, Lin, Yiqun, additional, Lockey, Andrew S., additional, Macneil, Finlay, additional, Maconochie, Ian K., additional, John Madar, R., additional, Malta Hansen, Carolina, additional, Masterson, Siobhan, additional, Matsuyama, Tasuku, additional, McKinlay, Christopher J.D., additional, Meyran, Daniel, additional, Monnelly, Vix, additional, Nadkarni, Vinay, additional, Nakwa, Firdose L., additional, Nation, Kevin J., additional, Nehme, Ziad, additional, Nemeth, Michael, additional, Neumar, Robert W., additional, Nicholson, Tonia, additional, Nikolaou, Nikolaos, additional, Nishiyama, Chika, additional, Norii, Tatsuya, additional, Nuthall, Gabrielle A., additional, Ohshimo, Shinchiro, additional, Olasveengen, Theresa M., additional, Gene Ong, Yong-Kwang, additional, Orkin, Aaron M., additional, Parr, Michael J., additional, Patocka, Catherine, additional, Perkins, Gavin D., additional, Perlman, Jeffrey M., additional, Rabi, Yacov, additional, Raitt, James, additional, Ramachandran, Shalini, additional, Ramaswamy, Viraraghavan V., additional, Raymond, Tia T., additional, Reis, Amelia G., additional, Reynolds, Joshua C., additional, Ristagno, Giuseppe, additional, Rodriguez-Nunez, Antonio, additional, Roehr, Charles C., additional, Rüdiger, Mario, additional, Sakamoto, Tetsuya, additional, Sandroni, Claudio, additional, Sawyer, Taylor L., additional, Schexnayder, Steve M., additional, Schmölzer, Georg M., additional, Schnaubelt, Sebastian, additional, Semeraro, Federico, additional, Singletary, Eunice M., additional, Skrifvars, Markus B., additional, Smith, Christopher M., additional, Soar, Jasmeet, additional, Stassen, Willem, additional, Sugiura, Takahiro, additional, Tijssen, Janice A., additional, Topjian, Alexis A., additional, Trevisanuto, Daniele, additional, Vaillancourt, Christian, additional, Wyckoff, Myra H., additional, Wyllie, Jonathan P., additional, Yang, Chih-Wei, additional, Yeung, Joyce, additional, Zelop, Carolyn M., additional, Zideman, David A., additional, Nolan, Jerry P., additional, Barcala-Furelos, Roberto, additional, Beerman, Stephen B., additional, Bruckner, Marlies, additional, Castrén, Maaret, additional, Chong, ShuLing, additional, Claesson, Andreas, additional, Dunne, Cody L., additional, Finan, Emer, additional, Fukuda, Tatsuma, additional, Lalgudi Ganesan, Saptharishi, additional, Gately, Callum, additional, Gois, Aecio, additional, Gray, Seth, additional, Halamek, Louis P., additional, Hoover, Amber V., additional, Hurst, Cameron, additional, Josephsen, Justin, additional, Kollander, Louise, additional, Omar Kamlin, C., additional, Kool, Mirjam, additional, Li, Lei, additional, Mecrow, Thomas S., additional, Montgomery, William, additional, Ristau, Patrick, additional, Jayashree, Muralidharan, additional, Schmidt, Andrew, additional, Scquizzato, Tommaso, additional, Seesink, Jeroen, additional, Sempsrott, Justin, additional, Lee Solevåg, Anne, additional, Strand, Marya L., additional, Szpilman, David, additional, Szyld, Edgardo, additional, Thom, Ogilvie, additional, Tobin, Joshua M., additional, Trang, Jacinta, additional, Webber, Jonathon, additional, Webster, Hannah K., additional, and Wellsford, Michelle, additional

Published
2024
Full Text
View/download PDF

28. Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

Author

Steven X. Cho, Ina Rudloff, Jason C. Lao, Merrin A. Pang, Rimma Goldberg, Christine B. Bui, Catriona A. McLean, Magdalena Stock, Tilman E. Klassert, Hortense Slevogt, Niamh E. Mangan, Wei Cheng, Doris Fischer, Stefan Gfroerer, Manjeet K. Sandhu, Devi Ngo, Alexander Bujotzek, Laurent Lariviere, Felix Schumacher, Georg Tiefenthaler, Friederike Beker, Clare Collins, C. Omar F. Kamlin, Kai König, Atul Malhotra, Kenneth Tan, Christiane Theda, Alex Veldman, Andrew M. Ellisdon, James C. Whisstock, Philip J. Berger, Claudia A. Nold-Petry, and Marcel F. Nold

Subjects
Science
Abstract

Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.

Published
2020
Full Text
View/download PDF

30. A COVID-19 field hospital in a conference centre – The Cape Town, South Africa experience

Author

Bonny Bulajic, Kamlin Ekambaram, Colleen Saunders, Vanessa Naidoo, Lee Wallis, Nabeela Amien, Tasleem Ras, Klaus von Pressentin, Gamuchirai Tadzimirwa, Nadia Hussey, Steve Reid, and Peter Hodkinson

Subjects
covid, field hospital, multidisciplinary, palliative care, south africa, health services, pandemic, infectious diseases, Medicine, Public aspects of medicine, RA1-1270
Abstract

Background: The coronavirus pandemic has put extreme pressure on health care services in South Africa. Aim: To describe the design, patients and outcomes of a field hospital during the first wave of the coronavirus disease 2019 (COVID-19) pandemic. Setting: The Cape Town International Convention Centre was the first location in Cape Town to be commissioned as a field hospital that would serve as an intermediate care bed facility. Methods: This was a retrospective descriptive study of patients admitted to this facility between 8th June 2020 and 14th August 2020 using deidentified data extracted from patient records. Results: There were 1502 patients admitted, 56.4% female, with a mean age of 58.6 years (standard deviation [s.d.]: 14.2). The majority of patients (82.9%) had at least one comorbidity, whilst 15.4% had three or more. Nearly 80.0% (79.8%) of patients required oxygen and 63.5% received steroids, and only 5.7% of patients were required to be transferred for escalation of care. The mean length of stay was 6 days (s.d.: 4.8) with an overall mortality of 5.7%. Conclusion: This study highlights the role of a field hospital in providing surge capacity. Its use halved the predicted duration of stay at acute care hospitals, allowing them the capacity to manage more unstable and critical patients. Adaptability and responsivity as well as adequate referral platforms proved to be crucial. Daily communication with the whole health care service platform was a critical success factor. This study provides information to assist future health planning and strategy development in the current pandemic and future disease outbreaks.

Published
2021
Full Text
View/download PDF

40. A multicentre, randomised trial of stabilisation with nasal high flow during neonatal endotracheal intubation (the SHINE trial): a study protocol

Author

Susan M Donath, Peter G Davis, Brett James Manley, Louise S Owen, Kate A Hodgson, Camille Omar Kamlin, and Calum T Roberts

Subjects
Medicine
Abstract

Introduction Neonatal endotracheal intubation is an essential but potentially destabilising procedure. With an increased focus on avoiding mechanical ventilation, particularly in preterm infants, there are fewer opportunities for clinicians to gain proficiency in this important emergency skill. Rates of successful intubation at the first attempt are relatively low, and adverse event rates are high, when compared with intubations in paediatric and adult populations. Interventions to improve operator success and patient stability during neonatal endotracheal intubations are needed. Using nasal high flow therapy extends the safe apnoea time of adults undergoing upper airway surgery and during endotracheal intubation. This technique is untested in neonates.Methods and analysis The Stabilisation with nasal High flow during Intubation of NEonates (SHINE) trial is a multicentre, randomised controlled trial comparing the use of nasal high flow during neonatal intubation with standard care (no nasal high flow). Intubations are randomised individually, and stratified by site, use of premedications, and postmenstrual age (20% from preintubation baseline and/or bradycardia (

Published
2020
Full Text
View/download PDF

41. Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol

Author

Stuart B Hooper, Anup C Katheria, Venkataseshan Sundaram, Lisa Askie, Martin Kluckow, Shigeharu Hosono, Alan Montgomery, Eugene Dempsey, Walid El-Naggar, William Tarnow-Mordi, Heike Rabe, Ronny Knol, Lelia Duley, Thomas Debray, Amir Kugelman, Kellie Murphy, Anna Lene Seidler, Kylie E Hunter, Michael Meyer, Catalina De Paco Matallana, John Kattwinkel, Judith Mercer, Justin Josephsen, Karen Fairchild, Ola Andersson, Vikram Datta, Graeme Polglase, Angie Barba, John Simes, Ava Grace Tan-Koay, Anu George, Anu Sachdeva, Arjan Te Pas, Ashish K C, Bimlesh Kumar, Carl Backes, Chamnan Tanprasertkul, Chayatat Ruangkit, G Ram Mohan, Gillian Gyte, Guillermo Carroli, Heidi Al-Wassia, Hytham Atia, Islam Nour, Jiangqin Liu, John Bauer, Kristy Robledo, Lakhbir Dhaliwal, Laura Perretta, Lin Ling, Manoj Varanattu, Maria Goya, Musa Silahli, Neelam Kler, Neil Finer, Omar Kamlin, Peter Giannone, Pharuhad Pongmee, Prisana Panichkul, Sandeep Kadam, Sangkae Chamnanvanakij, Shiraz Badurdeen, Simone Pratesi, Thomas Ranjit, Victor Lago Leal, and Waldemar Carlo

Subjects
Medicine
Abstract

IntroductionTiming of cord clamping and other cord management strategies may improve outcomes at preterm birth. However, it is unclear whether benefits apply to all preterm subgroups. Previous and current trials compare various policies, including time-based or physiology-based deferred cord clamping, and cord milking. Individual participant data (IPD) enable exploration of different strategies within subgroups. Network meta-analysis (NMA) enables comparison and ranking of all available interventions using a combination of direct and indirect comparisons.Objectives(1) To evaluate the effectiveness of cord management strategies for preterm infants on neonatal mortality and morbidity overall and for different participant characteristics using IPD meta-analysis. (2) To evaluate and rank the effect of different cord management strategies for preterm births on mortality and other key outcomes using NMA.Methods and analysisSystematic searches of Medline, Embase, clinical trial registries, and other sources for all ongoing and completed randomised controlled trials comparing cord management strategies at preterm birth (before 37 weeks’ gestation) have been completed up to 13 February 2019, but will be updated regularly to include additional trials. IPD will be sought for all trials; aggregate summary data will be included where IPD are unavailable. First, deferred clamping and cord milking will be compared with immediate clamping in pairwise IPD meta-analyses. The primary outcome will be death prior to hospital discharge. Effect differences will be explored for prespecified participant subgroups. Second, all identified cord management strategies will be compared and ranked in an IPD NMA for the primary outcome and the key secondary outcomes. Treatment effect differences by participant characteristics will be identified. Inconsistency and heterogeneity will be explored.Ethics and disseminationEthics approval for this project has been granted by the University of Sydney Human Research Ethics Committee (2018/886). Results will be relevant to clinicians, guideline developers and policy-makers, and will be disseminated via publications, presentations and media releases.Registration numberAustralian New Zealand Clinical Trials Registry (ANZCTR) (ACTRN12619001305112) and International Prospective Register of Systematic Reviews (PROSPERO, CRD42019136640).

Published
2020
Full Text
View/download PDF

44. Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

Author

Cho, Steven X., Rudloff, Ina, Lao, Jason C., Pang, Merrin A., Goldberg, Rimma, Bui, Christine B., McLean, Catriona A., Stock, Magdalena, Klassert, Tilman E., Slevogt, Hortense, Mangan, Niamh E., Cheng, Wei, Fischer, Doris, Gfroerer, Stefan, Sandhu, Manjeet K., Ngo, Devi, Bujotzek, Alexander, Lariviere, Laurent, Schumacher, Felix, Tiefenthaler, Georg, Beker, Friederike, Collins, Clare, Kamlin, C. Omar F., König, Kai, Malhotra, Atul, Tan, Kenneth, Theda, Christiane, Veldman, Alex, Ellisdon, Andrew M., Whisstock, James C., Berger, Philip J., Nold-Petry, Claudia A., and Nold, Marcel F.

Published
2020
Full Text
View/download PDF

46. Cerebral Oxygenation during Neonatal Intubation with Nasal High Flow: A Sub-Study of the SHINE Randomized Trial

Author

van der Veeken, E, Manley, BJ, Owen, L, Kamlin, O, Roberts, C, Newman, S, Francis, K, Donath, S, Davis, P, Cuzzilla, R, Hodgson, KA, van der Veeken, E, Manley, BJ, Owen, L, Kamlin, O, Roberts, C, Newman, S, Francis, K, Donath, S, Davis, P, Cuzzilla, R, and Hodgson, KA

Abstract

INTRODUCTION: Nasal high flow (nHF) improves the likelihood of successful neonatal intubation on the first attempt without physiological instability. The effect of nHF on cerebral oxygenation is unknown. The aim of this study was to compare cerebral oxygenation during endotracheal intubation in neonates receiving nHF and those receiving standard care. METHODS: A sub-study of a multicentre randomized trial of nHF during neonatal endotracheal intubation. A subset of infants had near-infrared spectroscopy (NIRS) monitoring. Eligible infants were randomly assigned to nHF or standard care during the first intubation attempt. NIRS sensors provided continuous regional cerebral oxygen saturation (rScO2) monitoring. The procedure was video recorded, and peripheral oxygen saturation and rScO2 data were extracted at 2-second intervals. The primary outcome was the average difference in rScO2 from baseline during the first intubation attempt. Secondary outcomes included average rScO2 and rate of change of rScO2. RESULTS: Nineteen intubations were analyzed (11 nHF; 8 standard care). Median (interquartile range [IQR]) postmenstrual age was 27 (26.5-29) weeks, and weight was 828 (716-1,135) g. Median change in rScO2 from baseline was -1.5% (-5.3 to 0.0) in the nHF group and -9.4% (-19.6 to -4.5) in the standard care group. rScO2 fell more slowly in infants managed with nHF compared with standard care: median (IQR) rScO2 change -0.08 (-0.13 to 0.00) % per second and -0.36 (-0.66 to -0.22) % per second, respectively. CONCLUSIONS: In this small sub-study, regional cerebral oxygen saturation was more stable in neonates who received nHF during intubation compared with standard care.

Published
2023

47. Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: statistical analysis plan for the international, multicenter, randomized PLUSS trial

Author

Francis, KL, McKinlay, CJD, Kamlin, COF, Cheong, JLY, Dargaville, PA, Dawson, JA, Doyle, LW, Jacobs, SE, Davis, PG, Donath, SM, Manley, BJ, Francis, KL, McKinlay, CJD, Kamlin, COF, Cheong, JLY, Dargaville, PA, Dawson, JA, Doyle, LW, Jacobs, SE, Davis, PG, Donath, SM, and Manley, BJ

Abstract

BACKGROUND: Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks' gestation and is associated with an increased risk of adverse neurodevelopmental and respiratory outcomes in childhood. Effective and safe prophylactic therapies for BPD are urgently required. Systemic corticosteroids reduce rates of BPD in the short term but are associated with poorer neurodevelopmental outcomes if given to ventilated infants in the first week after birth. Intratracheal administration of corticosteroid admixed with exogenous surfactant could overcome these concerns by minimizing systemic sequelae. Several small, randomized trials have found intratracheal budesonide in a surfactant vehicle to be a promising therapy to increase survival free of BPD. The primary objective of the PLUSS trial is to determine whether intratracheal budesonide mixed with surfactant increases survival free of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age (PMA) in extremely preterm infants born before 28 weeks' gestation. METHODS: An international, multicenter, double-blinded, randomized trial of intratracheal budesonide (a corticosteroid) mixed with surfactant for extremely preterm infants to increase survival free of BPD at 36 weeks' postmenstrual age (PMA; primary outcome). Extremely preterm infants aged < 48 h after birth are eligible if (1) they are mechanically ventilated, or (2) they are receiving non-invasive respiratory support and there is a clinical decision to treat with surfactant. The intervention is budesonide (0.25 mg/kg) mixed with poractant alfa (200 mg/kg first intervention, 100 mg/kg if second intervention), administered intratracheally via an endotracheal tube or thin catheter. The comparator is poractant alfa alone (at the same doses). Secondary outcomes include the components of the primary outcome (death, BPD prior to or at 36 weeks' PMA), and potential systemic side effects of cort

Published
2023

48. Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: study protocol for the international, multicenter, randomized PLUSS trial

Author

Manley, BJ, Kamlin, COF, Donath, S, Huang, L, Birch, P, Cheong, JLY, Dargaville, PA, Dawson, JA, Doyle, LW, Jacobs, SE, Wilson, R, Davis, PG, McKinlay, CJD, Manley, BJ, Kamlin, COF, Donath, S, Huang, L, Birch, P, Cheong, JLY, Dargaville, PA, Dawson, JA, Doyle, LW, Jacobs, SE, Wilson, R, Davis, PG, and McKinlay, CJD

Abstract

BACKGROUND: Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks' gestation and is associated with an increased risk of adverse neurodevelopmental and respiratory outcomes in childhood. Effective and safe prophylactic therapies for BPD are urgently required. Systemic corticosteroids reduce rates of BPD in the short-term but are associated with poorer neurodevelopmental outcomes if given to ventilated infants in the first week after birth. Intratracheal administration of corticosteroid admixed with exogenous surfactant could overcome these concerns by minimizing systemic sequelae. Several small, randomized trials have found intratracheal budesonide in a surfactant vehicle to be a promising therapy to increase survival free of BPD. METHODS: An international, multicenter, double-blinded, randomized trial of intratracheal budesonide (a corticosteroid) mixed with surfactant for extremely preterm infants to increase survival free of BPD at 36 weeks' postmenstrual age (PMA; primary outcome). Extremely preterm infants aged < 48 h after birth are eligible if: (1) they are mechanically ventilated, or (2) they are receiving non-invasive respiratory support and there is a clinical decision to treat with surfactant. The intervention is budesonide (0.25 mg/kg) mixed with poractant alfa (200 mg/kg first intervention, 100 mg/kg if second intervention), administered intratracheally via an endotracheal tube or thin catheter. The comparator is poractant alfa alone (at the same doses). Secondary outcomes include the components of the primary outcome (death, BPD prior to or at 36 weeks' PMA), potential systemic side effects of corticosteroids, cost-effectiveness, early childhood health until 2 years of age, and neurodevelopmental outcomes at 2 years of age (corrected for prematurity). DISCUSSION: Combining budesonide with surfactant for intratracheal administration is a simple intervention that may r

Published
2023

49. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Berg, K. M., Bray, J. E., Ng, K. -C., Liley, H. G., Greif, R., Carlson, J. N., Morley, P. T., Drennan, I. R., Smyth, M., Scholefield, B. R., Weiner, G. M., Cheng, A., Djarv, T., Abelairas-Gomez, C., Acworth, J., Andersen, L. W., Atkins, D. L., Berry, D. C., Bhanji, F., Bierens, J., Couto, T. B., Borra, V., Bottiger, B. W., Bradley, R. N., Breckwoldt, J., Cassan, P., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Dassanayake, V., Davis, P. G., Dawson, J. A., de Almeida, M. F., De Caen, A. R., Deakin, C. D., Dicker, B., Douma, M. J., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Fijacko, N., Finn, J. C., Flores, G. E., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M. E., Kloeck, D. A., Kudenchuk, P., Kule, A., Kurosawa, H., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y., Lockey, A. S., Macneil, F., Maconochie, I. K., Madar, R. J., Hansen, C. M., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Monnelly, V., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., Ohshimo, S., Olasveengen, T. M., Ong, Y. -K. G., Orkin, A. M., Parr, M. J., Patocka, C., Perkins, G. D., Perlman, J. M., Rabi, Y., Raitt, J., Ramachandran, S., Ramaswamy, V. V., Raymond, T. T., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Singletary, E. M., Skrifvars, M. B., Smith, C. M., Soar, J., Stassen, W., Sugiura, T., Tijssen, J. A., Topjian, A. A., Trevisanuto, D., Vaillancourt, C., Wyckoff, M. H., Wyllie, J. P., Yang, C. -W., Yeung, J., Zelop, C. M., Zideman, D. A., Nolan, J. P., Barcala-Furelos, R., Beerman, S. B., Bruckner, M., Castren, M., Chong, S., Claesson, A., Dunne, C. L., Finan, E., Fukuda, T., Ganesan, S. L., Gately, C., Gois, A., Gray, S., Halamek, L. P., Hoover, A. V., Hurst, C., Josephsen, J., Kollander, L., Kamlin, C. O., Kool, M., Li, L., Mecrow, T. S., Montgomery, W., Ristau, P., Jayashree, M., Schmidt, A., Scquizzato, T. -M., Seesink, J., Sempsrott, J., Solevag, A. L., Strand, M. L., Szpilman, D., Szyld, E., Thom, O., Tobin, J. M., Trang, J., Webber, J., Webster, H. K., Wellsford, M., Sandroni C. (ORCID:0000-0002-8878-2611), Berg, K. M., Bray, J. E., Ng, K. -C., Liley, H. G., Greif, R., Carlson, J. N., Morley, P. T., Drennan, I. R., Smyth, M., Scholefield, B. R., Weiner, G. M., Cheng, A., Djarv, T., Abelairas-Gomez, C., Acworth, J., Andersen, L. W., Atkins, D. L., Berry, D. C., Bhanji, F., Bierens, J., Couto, T. B., Borra, V., Bottiger, B. W., Bradley, R. N., Breckwoldt, J., Cassan, P., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Dassanayake, V., Davis, P. G., Dawson, J. A., de Almeida, M. F., De Caen, A. R., Deakin, C. D., Dicker, B., Douma, M. J., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Fijacko, N., Finn, J. C., Flores, G. E., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M. E., Kloeck, D. A., Kudenchuk, P., Kule, A., Kurosawa, H., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y., Lockey, A. S., Macneil, F., Maconochie, I. K., Madar, R. J., Hansen, C. M., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Monnelly, V., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., Ohshimo, S., Olasveengen, T. M., Ong, Y. -K. G., Orkin, A. M., Parr, M. J., Patocka, C., Perkins, G. D., Perlman, J. M., Rabi, Y., Raitt, J., Ramachandran, S., Ramaswamy, V. V., Raymond, T. T., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Singletary, E. M., Skrifvars, M. B., Smith, C. M., Soar, J., Stassen, W., Sugiura, T., Tijssen, J. A., Topjian, A. A., Trevisanuto, D., Vaillancourt, C., Wyckoff, M. H., Wyllie, J. P., Yang, C. -W., Yeung, J., Zelop, C. M., Zideman, D. A., Nolan, J. P., Barcala-Furelos, R., Beerman, S. B., Bruckner, M., Castren, M., Chong, S., Claesson, A., Dunne, C. L., Finan, E., Fukuda, T., Ganesan, S. L., Gately, C., Gois, A., Gray, S., Halamek, L. P., Hoover, A. V., Hurst, C., Josephsen, J., Kollander, L., Kamlin, C. O., Kool, M., Li, L., Mecrow, T. S., Montgomery, W., Ristau, P., Jayashree, M., Schmidt, A., Scquizzato, T. -M., Seesink, J., Sempsrott, J., Solevag, A. L., Strand, M. L., Szpilman, D., Szyld, E., Thom, O., Tobin, J. M., Trang, J., Webber, J., Webster, H. K., Wellsford, M., and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

The International Liaison Committee on Resuscitation engages in a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation and first aid science. Draft Consensus on Science With Treatment Recommendations are posted online throughout the year, and this annual summary provides more concise versions of the final Consensus on Science With Treatment Recommendations from all task forces for the year. Topics addressed by systematic reviews this year include resuscitation of cardiac arrest from drowning, extracorporeal cardiopulmonary resuscitation for adults and children, calcium during cardiac arrest, double sequential defibrillation, neuroprognostication after cardiac arrest for adults and children, maintaining normal temperature after preterm birth, heart rate monitoring methods for diagnostics in neonates, detection of exhaled carbon dioxide in neonates, family presence during resuscitation of adults, and a stepwise approach to resuscitation skills training. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, using Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence-to-Decision Framework Highlights sections. In addition, the task forces list priority knowledge gaps for further research. Additional topics are addressed with scoping reviews and evidence updates.

Published
2023

50. Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial.

Author

Dargaville, Peter A., Kamlin, C. Omar F., Orsini, Francesca, Wang, Xiaofang, De Paoli, Antonio G., Kanmaz Kutman, H. Gozde, Cetinkaya, Merih, Kornhauser-Cerar, Lilijana, Derrick, Matthew, Özkan, Hilal, Hulzebos, Christian V., Schmölzer, Georg M., Aiyappan, Ajit, Lemyre, Brigitte, Kuo, Sheree, Rajadurai, Victor S., O'Shea, Joyce, Biniwale, Manoj, Ramanathan, Rangasamy, and Kushnir, Alla

Subjects
*NEURODEVELOPMENTAL treatment for infants, *MECONIUM aspiration syndrome, *PREMATURE infants, *CONTINUOUS positive airway pressure, *NEONATAL intensive care units, *SURFACE active agents, *RESPIRATORY distress syndrome
Abstract

Key Points: Question: For preterm infants with respiratory distress syndrome supported with continuous positive airway pressure (CPAP), does administration of surfactant via a thin catheter improve survival without moderate to severe neurodevelopmental disability (NDD) at 2 years of age compared with sham treatment? Findings: In this follow-up of a randomized clinical trial of 486 infants at 25 to 28 weeks' gestation, the composite outcome of death or NDD at 2 years of age occurred in 36.3% receiving minimally invasive surfactant therapy compared with 36.1% receiving sham treatment. Meaning: In preterm infants supported with CPAP, minimally invasive surfactant therapy did not lead to a reduction in the composite outcome of death or neurodevelopmental disability at 2 years of age. Importance: The long-term effects of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified. Objective: To examine the effect of MIST on death or neurodevelopmental disability (NDD) at 2 years' corrected age. Design, Setting, and Participants: Follow-up study of a randomized clinical trial with blinding of clinicians and outcome assessors conducted in 33 tertiary-level neonatal intensive care units in 11 countries. The trial included 486 infants with a gestational age of 25 to 28 weeks supported with continuous positive airway pressure (CPAP). Collection of follow-up data at 2 years' corrected age was completed on December 9, 2022. Interventions: Infants assigned to MIST (n = 242) received exogenous surfactant (200 mg/kg poractant alfa) via a thin catheter; those assigned to the control group (n = 244) received sham treatment. Main Outcomes and Measures: The key secondary outcome of death or moderate to severe NDD was assessed at 2 years' corrected age. Other secondary outcomes included components of this composite outcome, as well as hospitalizations for respiratory illness and parent-reported wheezing or breathing difficulty in the first 2 years. Results: Among the 486 infants randomized, 453 had follow-up data available (median gestation, 27.3 weeks; 228 females [50.3%]); data on the key secondary outcome were available in 434 infants. Death or NDD occurred in 78 infants (36.3%) in the MIST group and 79 (36.1%) in the control group (risk difference, 0% [95% CI, −7.6% to 7.7%]; relative risk [RR], 1.0 [95% CI, 0.81-1.24]); components of this outcome did not differ significantly between groups. Secondary respiratory outcomes favored the MIST group. Hospitalization with respiratory illness occurred in 49 infants (25.1%) in the MIST group vs 78 (38.2%) in the control group (RR, 0.66 [95% CI, 0.54-0.81]) and parent-reported wheezing or breathing difficulty in 73 (40.6%) vs 104 (53.6%), respectively (RR, 0.76 [95% CI, 0.63-0.90]). Conclusions and Relevance: In this follow-up study of a randomized clinical trial of preterm infants with respiratory distress syndrome supported with CPAP, MIST compared with sham treatment did not reduce the incidence of death or NDD by 2 years of age. However, infants who received MIST had lower rates of adverse respiratory outcomes during their first 2 years of life. Trial Registration: anzctr.org.au Identifier: ACTRN12611000916943 This follow-up study of a randomized clinical trial examines the effect of minimally invasive surfactant therapy, surfactant administration via a thin catheter, on death or neurodevelopmental disability at 2 years' corrected age. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results