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Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.242592c0bc1c49d49d4bb66a63310f56
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-19400-w