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129 results on '"Kamil, T"'

1. Multiple Sulfatase Deficiency (MSD)

Author

Indika, Neluwa-Liyanage R., primary, Uçar, Kamil T., additional, Law, Eric C., additional, Senarathne, Udara D., additional, Doery, James C. G., additional, and Stepien, Karolina M., additional

Published
2023
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2. Designing Economic Socialization System in the Educational Process of Technological University

Author

Shaidullina, Rimma M., Amirov, Artur F., Muhametshin, Vyacheslav S., and Tyncherov, Kamil T.

Abstract

The relevance of this study is related to the fact that the necessity of compliance between the professional education system and progressive tendencies of world economy development demanded the formation of a new generation of economically socialized engineering and technical specialists, who own a sufficient level of economic competences, that will allow successful integration into the socio-economic environment. The purpose of the paper is to create the scientific basis of content, structure clarifying, creating and implementation the pedagogical conditions of students' economic socialization, considered as a process and the result of individual inclusion into the system of socio-economic relations in the society. The leading method of studying this problem is the project method, allowing to design a system of economic socialization of students on the basis of the relationship between the essential characteristics of the process of economic socialization, identified by socializing potential of the educational environment in technological university and transformative actions for realizing this potential to achieve the goals and objectives of the students' economic socialization. In the paper it is determined that the pedagogical activity on the designing of economic socialization system includes the following stages: the first (preliminary) stage involves planning of educational activities for the realization the target component of underway project (diagnosis, promotion of ideas, identification of goals and objectives of economic socialization, expected outcomes and the criteria for their evaluation), and, ultimately, development of the project. The second stage of the design is the project realization phase including the content, activity and technological components of the educational process. Third (reflective) stage includes analytical, corrective and remodeling aspects of pedagogical activity. The data from this paper have practical value in designing of economic socialization systems for future engineers, prove the causal dynamic nature of searching and the improvement of the educational process and offer opportunities to apply our approach to design educational systems in technological universities.

Published
2017

5. Development of an Optimal Model of Combined Radiation and Biological Lesions

Author

Timur R. Gaynutdinov, Konstantin N. Vagin, Yagafar M. Kurbangaleev, Kamil T. Ushmukhametov, Farit Kh Kalimullin, Vanentina A. Guryanova, Ilnar R. Yunusov, Aleksey V. Frolov, and Fanil R. Vafin

Subjects
Veterinary medicine, SF600-1100
Abstract

Since the search for the effective medication in combined lesions includes the selection of an optimal experimental model for such injuries, there is actually a study aimed at developing an optimal model of combined radiation-biology (Pasteurella) lesions. The pathogen Pasteurella multocida (as one of the most frequent pathogenic agents involved in both isolated and combined radiation-biology lesions of agricultural animals) was used as a model of a biological agent to reproduce experimental biological research. We employed the “Chinchilla” rabbits of 2.5–3.0 kg body weight as a biological model for doing combined radiation Pasteurella lesion. When determining the optimal model of combined radiation-biology (Pasteurella) lesion, we consider that in the joint action of various pathological agents on the organism, there is a synergistic effect of explosion agents, previously specifying minimal doses of external γ-radiation and pasteurellosis pathogen that in the joint action of nonfatal doses would be lethal. The first stage of the experiments determined the minimal doses of gamma rays and pasteurellosis pathogen that in joint action causes combined radiation-biology pathology. We examined 66 rabbits divided into 11 groups of 6 animals each to determine minimal doses of infectious agent-pasteurellosis pathogen. The animals of the first 9 groups were given subcutaneously Pasteurella species at doses 1·109, 1·108, 1·107, 1·106, 1·105, 1·104, 1·103, 1·102, and 1·101 of microbial cells per animal of 0.3 ml suspension in volume; the 10th group of animals were given saline solution; the 11th served as a biological control group. In determining the minimal doses of gamma rays, we conducted experimental tests on 36 rabbits, which have been exposed to external γ-radiation in the “PUMA” system with a 137Cs radiation source of the exposure dose of 5.38 R/min at doses 2.0, 4.0, 6.0, 8.0, 10, and 12 Gy. To specify the optimal model of radiation-pasteurellosis lesion, we used the rabbits subjected to a combined radiation-biology effect using minimal doses of gamma rays and pasteurellosis agent, leading to a lethal effect during their complex action. The researches revealed that 50% of the death of rabbits infected with pasteurellosis occurs using Pasteurella at a dose of 3.7·104 microbial cells per kilogram (LD50 = 3.7∙104 m.c./kg), and 50% of radiation death in rabbits occurs when irradiated their gamma rays at a dose of 8.0 Gy (LD50 = 8.0 Gy). The combined effect of nonlethal doses of the studied agents in the indicated doses on rabbits led to the aggravation of the course of radiation and pasteurellosis infection, causing the death of animals from combined radiation-pasteurellosis pathology. The model combined radiation-pasteurellosis disease ran its course rapidly, and the animals died 3 to 6 days after the onset. The autopsy of the animals that died from acute radiation-pasteurellosis pathogen had found swelling of the subcutaneous tissue in the pharynx and intermaxillary space of the neck, hyperemia, lymphoid nodular hyperplasia, numerous hemorrhages on the serous and mucous membranes and in the tissues of the parenchymal organs, serous or serous-fibrinous exudate, and in the chest and abdominal regions, pulmonary edema. The research stated that gamma radiation of rabbits at a dose of 8.0 Gy conducted before exposure with Pasteurella at LD50 (3.7·104 m.c./kg) declined the course of the pasteurellosis process, facilitated its generalization, and fastened the death of animals. Combined radiation-pasteurellosis infection ran its course rapidly, and the animals died within 3 to 6 days after the onset of the disease. The autopsy showed the pathologicoanatomic factors of the acute pasteurellosis: swelling of the subcutaneous tissue, purulent-catarrhal bronchopneumonitis, and pulmonary edema.

Published
2022
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11. Nonlinear and Linear Measures in the Differentiation of Postural Control in Patients after Total Hip or Knee Replacement and Healthy Controls

Author

Anna Hadamus, Michalina Błażkiewicz, Aleksandra J. Kowalska, Kamil T. Wydra, Marta Grabowicz, Małgorzata Łukowicz, Dariusz Białoszewski, and Wojciech Marczyński

Subjects
hip arthroplasty, knee arthroplasty, older adults, postural control, body balance, osteoarthritis, Medicine (General), R5-920
Abstract

Primary osteoarthritis treatments such as a total hip (THR) or knee (TKR) replacement lead to postural control changes reinforced by age. Balance tests such as standing with eyes open (EO) or closed (EC) give a possibility to calculate both linear and nonlinear indicators. This study aimed to find the group of linear and/or nonlinear measures that can differentiate healthy people and patients with TKR or THR from each other. This study enrolled 49 THR patients, 53 TKR patients, and 16 healthy controls. The center of pressure (CoP) path length, sample entropy (SampEn), fractal dimension (FD), and the largest Lyapunov exponent (LyE) were calculated separately for AP and ML directions from standing with EO/EC. Cluster analysis did not result in correct allocation to the groups according to all variables. The discriminant model included LyE (ML-EO, ML-EC, AP-EC), FD (AP-EO, ML-EC, AP-EC), CoP-path AP-EC, and SampEn AP-EC. Regression analysis showed that all nonlinear variables depend on the group. The CoP path length is different only in THR patients. It was concluded that standing with EC is a better way to assess the amount of regularity of CoP movement and attention paid to maintain balance. Nonlinear measures better differentiate TKR and THR patients from healthy controls.

Published
2022
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16. Biopolymer-Mediated Coating Influence on Wastewater Treatment Efficacy of Silver Nanoparticles Synthesized from Fungal Consortium

Author

Namasivayam, S. Karthick Raja, Kumar, S. Nivash, Kamil, T. Mohammed, and Ravi, T.

Abstract

Abstract: In the present study, wastewater treatment efficacy of silver nanoparticles synthesized from biomass of fungal consortium coated with chitosan was carried out. Nanoparticles were synthesized from dried biomass of fungal consortium stabilized with biocompatible polymer chitosan being characterized by various analytical techniques reveals high stable monodispersive spherical nanoparticles with the size range of 80–90 nm. Batch wastewater treatment studies under in vitro condition show polymer-stabilized nanoparticles brought about maximum reduction in various physicochemical parameters, and the reduction rate was high in increased incubation time. Chitosan-coated nanoparticles also reveal maximum inhibition of biofilm formation and viable count of pathogenic bacterial count. The present study would suggest the possible utilization of chitosan-stabilized silver nanoparticles in wastewater eco-friendly treatment process for the effective removal of various toxic contaminants. Graphic Abstract: Synthesized silver nanoparticles by the fungal consortium.

Published
2024
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17. THE ROLE OF INFORMATION TECHNOLOGIES IN ENSURING AND IMPROVING THE QUALITY OF MODERN HIGH-TECH PRODUCTS

Author

Kamil T. Muslimov and Aelita V. Shaburova

Subjects
Engineering management, business.industry, media_common.quotation_subject, Information technology, Quality (business), business, High tech, media_common
Abstract

At the moment, the most important problem of information technologies is their obsolescence. In turn, information technology plays a key role in improving the quality of high-tech products. The acquisition of state-of-the-art information systems and their logistics requires the adoption of innovative approaches in the design, production and provision of logistics services for their operation. The article discusses the factors that determine the importance of introducing CALS-technologies in modern computer logistics, which can significantly improve the economy of acquiring more modern technical systems. The comprehensive logistical support provided by the electronic design and operational documentation associated with standardization and continuous updating provides amazing benefits.

Published
2021
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18. Effectiveness of Early Rehabilitation with Exergaming in Virtual Reality on Gait in Patients after Total Knee Replacement

Author

Anna Hadamus, Michalina Błażkiewicz, Kamil T. Wydra, Aleksandra J. Kowalska, Małgorzata Łukowicz, Dariusz Białoszewski, and Wojciech Marczyński

Subjects
arthroplasty, gait analysis, games, knee, osteoarthritis, pressure mapping, spatiotemporal parameters, virtual reality, General Medicine
Abstract

Total knee replacement (TKR) is the treatment of choice for advanced stages of osteoarthritis but it requires good postoperative rehabilitation. This study aimed to assess the effectiveness of exercises using virtual reality to improve gait parameters in patients after TKR. Fifty-nine patients 7–14 days after TKR surgery were divided into a study group (VRG, n = 38) and a control group (CG, n = 21). Both groups underwent the same 4-week rehabilitation protocol. The VRG group had 12 additional nonimmersive virtual reality game sessions on the Virtual Balance Clinic prototype system at 30 min each, focusing on gait and balance improvement. Spatiotemporal, force and foot plantar pressure parameters were collected on an instrumented treadmill during a 30 s walk. The most significant improvement was in the symmetry indices of forefoot force, maximum forefoot force, loading response time, and preswing time (p < 0.05) in both groups. Gait speed increased by 31.25% and 44% in the VRG and CG groups, respectively (p < 0.005). However, the extra exergaming sessions did not significantly improve rehabilitation outcomes. Therefore, additional VR training does not improve gait better than standard rehabilitation alone, but the improvement of gait, especially its symmetry, is significant within the first six weeks after surgery.

Published
2022
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22. Global injury morbidity and mortality from 1990 to 2017: Results from the Global Burden of Disease Study 2017

Author

James, S, Castle, C, Dingels, Z, Fox, J, Hamilton, E, Liu, Z, S Roberts, N, Sylte, D, Henry, N, Legrand, K, Abdelalim, A, Abdoli, A, Abdollahpour, I, Abdulkader, R, Abedi, A, Abosetugn, A, Abushouk, A, Adebayo, O, Agudelo-Botero, M, Ahmad, T, Ahmed, R, Ahmed, M, Eddine Aichour, M, Alahdab, F, Alamene, G, Alanezi, F, Alebel, A, Alema, N, Alghnam, S, Al-Hajj, S, Ali, B, Ali, S, Alikhani, M, Alinia, C, Alipour, V, Aljunid, S, Almasi-Hashiani, A, Almasri, N, Altirkawi, K, Abdeldayem Amer, Y, Amini, S, Loreche Amit, A, Andrei, C, Ansari-Moghaddam, A, T Antonio, C, Yaw Appiah, S, Arabloo, J, Arab-Zozani, M, Arefi, Z, Aremu, O, Ariani, F, Arora, A, Asaad, M, Asghari, B, Awoke, N, Ayala Quintanilla, B, Ayano, G, Ayanore, M, Azari, S, Azarian, G, Badawi, A, Badiye, A, Bagli, E, Baig, A, Bairwa, M, Bakhtiari, A, Balachandran, A, Banach, M, Banerjee, S, Banik, P, Banstola, A, Barker-Collo, S, Barnighausen, T, Barrero, L, Barzegar, A, Bayati, M, Baye, B, Bedi, N, Behzadifar, M, Bekuma, T, Belete, H, Benjet, C, Bennett, D, Bensenor, I, Berhe, K, Bhardwaj, P, Bhat, A, Bhattacharyya, K, Bibi, S, Bijani, A, Bin Sayeed, M, Borges, G, Borzi, A, Boufous, S, Brazinova, A, Briko, N, Budhathoki, S, Car, J, Cardenas, R, Carvalho, F, Castaldelli-Maia, J, Castaneda-Orjuela, C, Castelpietra, G, Catala-Lopez, F, Cerin, E, Chandan, J, Chanie, W, Chattu, S, Chattu, V, Chatziralli, I, Chaudhary, N, Cho, D, Kabir Chowdhury, M, Chu, D, Colquhoun, S, Constantin, M, Costa, V, Damiani, G, Daryani, A, Davila-Cervantes, C, Demeke, F, Demis, A, Demoz, G, Demsie, D, Derakhshani, A, Deribe, K, Desai, R, Nasab, M, Da Silva, D, Dibaji Forooshani, Z, Doyle, K, Driscoll, T, Dubljanin, E, Adema, B, Eagan, A, Eftekhari, A, Ehsani-Chimeh, E, Sayed Zaki, M, Elemineh, D, El-Jaafary, S, El-Khatib, Z, Ellingsen, C, Emamian, M, Endalew, D, Eskandarieh, S, Faris, P, Faro, A, Farzadfar, F, Fatahi, Y, Fekadu, W, Ferede, T, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Feyissa, G, Filip, I, Fischer, F, Folayan, M, Foroutan, M, Francis, J, Franklin, R, Fukumoto, T, Geberemariyam, B, Gebre, A, Gebremedhin, K, Gebremeskel, G, Gebremichael, B, Gedefaw, G, Geta, B, Ghafourifard, M, Ghamari, F, Ghashghaee, A, Gholamian, A, Gill, T, Goulart, A, Grada, A, Grivna, M, Mohialdeen Gubari, M, Guimaraes, R, Guo, Y, Gupta, G, Haagsma, J, Hafezi-Nejad, N, Bidgoli, H, Hall, B, Hamadeh, R, Hamidi, S, Haro, J, Hasan, M, Hasanzadeh, A, Hassanipour, S, Hassankhani, H, Hassen, H, Havmoeller, R, Hayat, K, Hendrie, D, Heydarpour, F, Hijar, M, Ho, H, Hoang, C, Hole, M, Holla, R, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Hu, G, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Inbaraj, L, Indriasih, E, Naghibi Irvani, S, Shariful Islam, S, Islam, M, Ivers, R, Jacobsen, K, Jahani, M, Jahanmehr, N, Jakovljevic, M, Jalilian, F, Jayaraman, S, Jayatilleke, A, Jha, R, John-Akinola, Y, Jonas, J, Joseph, N, Joukar, F, Jozwiak, J, Jungari, S, Jurisson, M, Kabir, A, Kadel, R, Kahsay, A, Kalankesh, L, Kalhor, R, Kamil, T, Kanchan, T, Kapoor, N, Karami, M, Kasaeian, A, Kassaye, H, Kavetskyy, T, Kebede, H, Keiyoro, P, Kelbore, A, Kelkay, B, Khader, Y, Khafaie, M, Khalid, N, Khalil, I, Khalilov, R, Khammarnia, M, Khan, E, Khan, M, Khanna, T, Khazaie, H, Shadmani, F, Khundkar, R, Kiirithio, D, Kim, Y, Kim, D, Kisa, A, Kisa, S, Komaki, H, M Kondlahalli, S, Korshunov, V, Koyanagi, A, G Kraemer, M, Krishan, K, Bicer, B, Kugbey, N, Kumar, V, Kumar, N, Kumar, G, Kumar, M, Kumaresh, G, Kurmi, O, Kuti, O, Vecchia, C, Lami, F, Lamichhane, P, Lang, J, Lansingh, V, Laryea, D, Lasrado, S, Latifi, A, Lauriola, P, Leasher, J, Huey Lee, S, Lenjebo, T, Levi, M, Li, S, Linn, S, Liu, X, Lopez, A, Lotufo, P, Lunevicius, R, Lyons, R, Madadin, M, El Razek, M, Mahotra, N, Majdan, M, Majeed, A, Malagon-Rojas, J, Maled, V, Malekzadeh, R, Malta, D, Manafi, N, Manafi, A, Manda, A, Manjunatha, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, M, Maravilla, J, March, L, Mason-Jones, A, Masoumi, S, Massenburg, B, Maulik, P, Meles, G, Melese, A, Melketsedik, Z, N Memiah, P, Mendoza, W, Menezes, R, Mengesha, M, Meretoja, T, Meretoja, A, Merie, H, Mestrovic, T, Miazgowski, B, Miazgowski, T, Miller, T, Mini, G, Mirica, A, Mirrakhimov, E, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, Y, Mohammad, K, Darwesh, A, Gholi Mezerji, N, Mohammadian-Hafshejani, A, Mohammadoo-Khorasani, M, Mohammadpourhodki, R, Mohammed, S, Mohammed, J, Mohebi, F, Molokhia, M, Monasta, L, Moodley, Y, Moosazadeh, M, Moradi, M, Moradi, G, Moradi-Lakeh, M, Moradpour, F, Morawska, L, Velasquez, I, Morisaki, N, Morrison, S, Mossie, T, Muluneh, A, Murthy, S, Musa, K, Mustafa, G, Nabhan, A, Nagarajan, A, Naik, G, Naimzada, M, Najafi, F, Nangia, V, Nascimento, B, Naserbakht, M, Nayak, V, Ndwandwe, D, Negoi, I, Ngunjiri, J, Nguyen, C, Thi Nguyen, H, Nikbakhsh, R, Anggraini Ningrum, D, Nnaji, C, Nyasulu, P, Ogbo, F, Oghenetega, O, Oh, I, Okunga, E, Olagunju, A, Olagunju, T, Bali, A, Onwujekwe, O, Asante, K, Orpana, H, Ota, E, Otstavnov, N, Otstavnov, S, Mahesh, P, Padubidri, J, Pakhale, S, Pakshir, K, Panda-Jonas, S, Park, E, Patel, S, Pathak, A, Pati, S, Patton, G, Paulos, K, Peden, A, Filipino Pepito, V, Pereira, J, Pham, H, Phillips, M, Pinheiro, M, Polibin, R, Polinder, S, Poustchi, H, Prakash, S, Angga Pribadi, D, Puri, P, Syed, Z, Rabiee, M, Rabiee, N, Radfar, A, Rafay, A, Rafiee, A, Rafiei, A, Rahim, F, Rahimi, S, Rahimi-Movaghar, V, Rahman, M, Rajabpour-Sanati, A, Rajati, F, Rakovac, I, Ranganathan, K, Rao, S, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, S, Rawal, L, Rawassizadeh, R, Renjith, V, N Renzaho, A, Resnikoff, S, Rezapour, A, Ribeiro, A, Rickard, J, Rios Gonzalez, C, Ronfani, L, Roshandel, G, Saad, A, Sabde, Y, Sabour, S, Saddik, B, Safari, S, Safari-Faramani, R, Safarpour, H, Safdarian, M, Sajadi, S, Salamati, P, Salehi, F, Zahabi, S, Rashad Salem, M, Salem, H, Salman, O, Salz, I, Samy, A, Sanabria, J, Riera, L, Santric Milicevic, M, Sarker, A, Sarveazad, A, Sathian, B, Sawhney, M, Sawyer, S, Saxena, S, Sayyah, M, Schwebel, D, Seedat, S, Senthilkumaran, S, Sepanlou, S, Seyedmousavi, S, Sha, F, Shaahmadi, F, Shahabi, S, Shaikh, M, Shams-Beyranvand, M, Shamsizadeh, M, Sharif-Alhoseini, M, Sharifi, H, Sheikh, A, Shigematsu, M, Shin, J, Shiri, R, Siabani, S, Sigfusdottir, I, Singh, P, Singh, J, Sinha, D, Smarandache, C, R Smith, E, Soheili, A, Soleymani, B, Soltanian, A, Soriano, J, Sorrie, M, Soyiri, I, Stein, D, Stokes, M, Sufiyan, M, Rasul Suleria, H, Sykes, B, Tabares-Seisdedos, R, Tabb, K, Taddele, B, Tadesse, D, Tamiru, A, Tarigan, I, Tefera, Y, Tehrani-Banihashemi, A, Tekle, M, Tekulu, G, Tesema, A, Tesfay, B, Thapar, R, Tilahune, A, Tlaye, K, Tohidinik, H, Topor-Madry, R, Tran, B, Tran, K, Tripathy, J, Tsai, A, Car, L, Ullah, S, Ullah, I, Umar, M, Unnikrishnan, B, Upadhyay, E, Uthman, O, Valdez, P, Vasankari, T, Venketasubramanian, N, Violante, F, Vlassov, V, Waheed, Y, Weldesamuel, G, Werdecker, A, Wiangkham, T, Wolde, H, Woldeyes, D, Wondafrash, D, Wondmeneh, T, Wondmieneh, A, Wu, A, Yadav, R, Yadollahpour, A, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Yip, P, Yisma, E, Yonemoto, N, Yoon, S, Youm, Y, Younis, M, Yousefi, Z, Yu, Y, Yu, C, Yusefzadeh, H, Moghadam, T, Zaidi, Z, Zaman, S, Zamani, M, Zamanian, M, Zandian, H, Zarei, A, Zare, F, Zhang, Z, Zhang, Y, Zodpey, S, Dandona, L, Dandona, R, Degenhardt, L, Dharmaratne, S, Hay, S, Mokdad, A, Reiner Jr, R, Sartorius, B, Vos, T, James S. L., Castle C. D., Dingels Z. V., Fox J. T., Hamilton E. B., Liu Z., S Roberts N. L., Sylte D. O., Henry N. J., Legrand K. E., Abdelalim A., Abdoli A., Abdollahpour I., Abdulkader R. S., Abedi A., Abosetugn A. E., Abushouk A. I., Adebayo O. M., Agudelo-Botero M., Ahmad T., Ahmed R., Ahmed M. B., Eddine Aichour M. T., Alahdab F., Alamene G. M., Alanezi F. M., Alebel A., Alema N. M., Alghnam S. A., Al-Hajj S., Ali B. A., Ali S., Alikhani M., Alinia C., Alipour V., Aljunid S. M., Almasi-Hashiani A., Almasri N. A., Altirkawi K., Abdeldayem Amer Y. S., Amini S., Loreche Amit A. M., Andrei C. L., Ansari-Moghaddam A., T Antonio C. A., Yaw Appiah S. C., Arabloo J., Arab-Zozani M., Arefi Z., Aremu O., Ariani F., Arora A., Asaad M., Asghari B., Awoke N., Ayala Quintanilla B. P., Ayano G., Ayanore M. A., Azari S., Azarian G., Badawi A., Badiye A. D., Bagli E., Baig A. A., Bairwa M., Bakhtiari A., Balachandran A., Banach M., Banerjee S. K., Banik P. C., Banstola A., Barker-Collo S. L., Barnighausen T. W., Barrero L. H., Barzegar A., Bayati M., Baye B. A., Bedi N., Behzadifar M., Bekuma T. T., Belete H., Benjet C., Bennett D. A., Bensenor I. M., Berhe K., Bhardwaj P., Bhat A. G., Bhattacharyya K., Bibi S., Bijani A., Bin Sayeed M. S., Borges G., Borzi A. M., Boufous S., Brazinova A., Briko N. I., Budhathoki S. S., Car J., Cardenas R., Carvalho F., Castaldelli-Maia J. M., Castaneda-Orjuela C. A., Castelpietra G., Catala-Lopez F., Cerin E., Chandan J. S., Chanie W. F., Chattu S. K., Chattu V. K., Chatziralli I., Chaudhary N., Cho D. Y., Kabir Chowdhury M. A., Chu D. -T., Colquhoun S. M., Constantin M. -M., Costa V. M., Damiani G., Daryani A., Davila-Cervantes C. A., Demeke F. M., Demis A. B., Demoz G. T., Demsie D. G., Derakhshani A., Deribe K., Desai R., Nasab M. D., Da Silva D. D., Dibaji Forooshani Z. S., Doyle K. E., Driscoll T. R., Dubljanin E., Adema B. D., Eagan A. W., Eftekhari A., Ehsani-Chimeh E., Sayed Zaki M. E., Elemineh D. A., El-Jaafary S. I., El-Khatib Z., Ellingsen C. L., Emamian M. H., Endalew D. A., Eskandarieh S., Faris P. S., Faro A., Farzadfar F., Fatahi Y., Fekadu W., Ferede T. Y., Fereshtehnejad S. -M., Fernandes E., Ferrara P., Feyissa G. T., Filip I., Fischer F., Folayan M. O., Foroutan M., Francis J. M., Franklin R. C., Fukumoto T., Geberemariyam B. S., Gebre A. K., Gebremedhin K. B., Gebremeskel G. G., Gebremichael B., Gedefaw G. A., Geta B., Ghafourifard M., Ghamari F., Ghashghaee A., Gholamian A., Gill T. K., Goulart A. C., Grada A., Grivna M., Mohialdeen Gubari M. I., Guimaraes R. A., Guo Y., Gupta G., Haagsma J. A., Hafezi-Nejad N., Bidgoli H. H., Hall B. J., Hamadeh R. R., Hamidi S., Haro J. M., Hasan M. M., Hasanzadeh A., Hassanipour S., Hassankhani H., Hassen H. Y., Havmoeller R., Hayat K., Hendrie D., Heydarpour F., Hijar M., Ho H. C., Hoang C. L., Hole M. K., Holla R., Hossain N., Hosseinzadeh M., Hostiuc S., Hu G., Ibitoye S. E., Ilesanmi O. S., Ilic I., Ilic M. D., Inbaraj L. 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O., Lasrado S., Latifi A., Lauriola P., Leasher J. L., Huey Lee S. W., Lenjebo T. L., Levi M., Li S., Linn S., Liu X., Lopez A. D., Lotufo P. A., Lunevicius R., Lyons R. A., Madadin M., El Razek M. M. A., Mahotra N. B., Majdan M., Majeed A., Malagon-Rojas J. N., Maled V., Malekzadeh R., Malta D. C., Manafi N., Manafi A., Manda A. -L., Manjunatha N., Mansour-Ghanaei F., Mansouri B., Mansournia M. A., Maravilla J. C., March L. M., Mason-Jones A. J., Masoumi S. Z., Massenburg B. B., Maulik P. K., Meles G. G., Melese A., Melketsedik Z. A., N Memiah P. T., Mendoza W., Menezes R. G., Mengesha M. B., Mengesha M. M., Meretoja T. J., Meretoja A., Merie H. E., Mestrovic T., Miazgowski B., Miazgowski T., Miller T. R., Mini G. K., Mirica A., Mirrakhimov E. M., Mirzaei-Alavijeh M., Mithra P., Moazen B., Moghadaszadeh M., Mohamadi E., Mohammad Y., Mohammad K. A., Darwesh A. M., Gholi Mezerji N. M., Mohammadian-Hafshejani A., Mohammadoo-Khorasani M., Mohammadpourhodki R., Mohammed S., Mohammed J. A., Mohebi F., Molokhia M., Monasta L., Moodley Y., Moosazadeh M., Moradi M., Moradi G., Moradi-Lakeh M., Moradpour F., Morawska L., Velasquez I. M., Morisaki N., Morrison S. D., Mossie T. B., Muluneh A. G., Murthy S., Musa K. I., Mustafa G., Nabhan A. F., Nagarajan A. J., Naik G., Naimzada M. D., Najafi F., Nangia V., Nascimento B. R., Naserbakht M., Nayak V., Ndwandwe D. E., Negoi I., Ngunjiri J. W., Nguyen C. T., Thi Nguyen H. L., Nikbakhsh R., Anggraini Ningrum D. N., Nnaji C. A., Nyasulu P. S., Ogbo F. A., Oghenetega O. B., Oh I. -H., Okunga E. W., Olagunju A. T., Olagunju T. O., Bali A. O., Onwujekwe O. E., Asante K. O., Orpana H. M., Ota E., Otstavnov N., Otstavnov S. S., Mahesh P. A., Padubidri J. R., Pakhale S., Pakshir K., Panda-Jonas S., Park E. -K., Patel S. K., Pathak A., Pati S., Patton G. C., Paulos K., Peden A. E., Filipino Pepito V. C., Pereira J., Pham H. Q., Phillips M. R., Pinheiro M., Polibin R. V., Polinder S., Poustchi H., Prakash S., Angga Pribadi D. R., Puri P., Syed Z. Q., Rabiee M., Rabiee N., Radfar A., Rafay A., Rafiee A., Rafiei A., Rahim F., Rahimi S., Rahimi-Movaghar V., Rahman M. A., Rajabpour-Sanati A., Rajati F., Rakovac I., Ranganathan K., Rao S. J., Rashedi V., Rastogi P., Rathi P., Rawaf S., Rawal L., Rawassizadeh R., Renjith V., N Renzaho A. M., Resnikoff S., Rezapour A., Ribeiro A. I., Rickard J., Rios Gonzalez C. M., Ronfani L., Roshandel G., Saad A. M., Sabde Y. D., Sabour S., Saddik B., Safari S., Safari-Faramani R., Safarpour H., Safdarian M., Sajadi S. M., Salamati P., Salehi F., Zahabi S. S., Rashad Salem M. R., Salem H., Salman O., Salz I., Samy A. M., Sanabria J., Riera L. S., Santric Milicevic M. M., Sarker A. R., Sarveazad A., Sathian B., Sawhney M., Sawyer S. M., Saxena S., Sayyah M., Schwebel D. C., Seedat S., Senthilkumaran S., Sepanlou S. G., Seyedmousavi S., Sha F., Shaahmadi F., Shahabi S., Shaikh M. A., Shams-Beyranvand M., Shamsizadeh M., Sharif-Alhoseini M., Sharifi H., Sheikh A., Shigematsu M., Shin J. I., Shiri R., Siabani S., Sigfusdottir I. D., Singh P. K., Singh J. A., Sinha D. N., Smarandache C. -G., R Smith E. U., Soheili A., Soleymani B., Soltanian A. R., Soriano J. B., Sorrie M. B., Soyiri I. N., Stein D. J., Stokes M. A., Sufiyan M. B., Rasul Suleria H. A., Sykes B. L., Tabares-Seisdedos R., Tabb K. M., Taddele B. W., Tadesse D. B., Tamiru A. T., Tarigan I. U., Tefera Y. M., Tehrani-Banihashemi A., Tekle M. G., Tekulu G. H., Tesema A. K., Tesfay B. E., Thapar R., Tilahune A. B., Tlaye K. G., Tohidinik H. R., Topor-Madry R., Tran B. X., Tran K. B., Tripathy J. P., Tsai A. C., Car L. T., Ullah S., Ullah I., Umar M., Unnikrishnan B., Upadhyay E., Uthman O. A., Valdez P. R., Vasankari T. J., Venketasubramanian N., Violante F. S., Vlassov V., Waheed Y., Weldesamuel G. T., Werdecker A., Wiangkham T., Wolde H. F., Woldeyes D. H., Wondafrash D. Z., Wondmeneh T. 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Abstract

Background: Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods: We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings: In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation: Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.

Published
2020

23. 131 Impact of Virtual Reality Training in Patients After HIP Arthroplasty on Pressure Distribution in Standing and Walking

Author

Anna Hadamus, Dariusz Białoszewski, Wojciech Marczyński, Kamil T. Wydra, Edyta Urbaniak, and Aleksandra Justyna Kowalska

Subjects
Aging, medicine.medical_specialty, Rehabilitation, business.industry, Forefoot, medicine.medical_treatment, General Medicine, Postoperative rehabilitation, Virtual reality, Gait, Hip arthroplasty, Physical medicine and rehabilitation, Gait analysis, Medicine, In patient, Geriatrics and Gerontology, business
Abstract

Introduction Patients after hip arthroplasty (THR) load the feet asymmetrically during standing or walking. Many reports indicate effectiveness of the Virtual Reality (VR) training in reeducation of postural stability, gait parameters and symmetry. The aim of this study was to assess if VR training programme based on non-walking exercises improve gait parameters or change foot pressure distribution. Materials and methods 56 patients after THR were randomly assigned to an experimental group (30 people) and a control group (26 people). The control group (CG) attended a standard post-operative rehabilitation programme, while 12 sessions of VR training were added to the standard programme in the experimental group (EG). Each patient performed standing with eyes opened and gait test on Zebris FDM-T treadmill. We calculated spatio-temporal parameters, foot pressure distribution and CoP displacement. The results were considered significant for p Results In the static tests, the force on the forefoot and the rearfoot of the operated limb increased in EG (p Most of the gait parameters improved significantly in both groups (p Conclusions 1. The significantly better gait performance parameters obtained in the experimental group indicate a better movement capacity in these patients. This suggests that using VR in motor re-education in patients after THR may enhance the effects of rehabilitation. 2. Further studies are necessary to assess the influence of VR training on pressure distribution both in static and dynamic tests.

Published
2019
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25. Do Cemented Dual-Mobility Cups Confer Stability for Patients at High Risk of Dislocation in Revision Total Hip Arthroplasty?

Author

Ran Schwarzkopf, Kamil T. Okroj, Craig J. Della Valle, Darren R. Plummer, and Perry J. Evangelista

Subjects
musculoskeletal diseases, 030222 orthopedics, medicine.medical_specialty, business.industry, equipment and supplies, Cementation (geology), Dual mobility, Surgery, 03 medical and health sciences, 0302 clinical medicine, Multicenter study, Acetabular component, Harris Hip Score, medicine, 030212 general & internal medicine, Implant, Dislocation, business, Total hip arthroplasty
Abstract

Dislocation is among the most commonly reported complications following revision total hip arthroplasty. Dual-mobility bearings may lower the risk of dislocation. The authors report the results of a multicenter study evaluating the use of a dual-mobility acetabular cup design that was cemented into a metal shell as part of complex acetabular reconstructions or in cases where the risk of dislocation was felt to be high, such as isolated bearing exchanges. Eighteen patients were identified for being at high risk of dislocation who underwent cementation of a dual-mobility shell that is specifically made for cementation, into a fully porous metal revision acetabular cup (10 patients) or into a well-fixed cup at the time of revision without removal of the existing acetabular component (eight patients). Patients were assessed clinically and radiographically at a minimum of 2 years for the evidence of dislocation, revision surgery, and implant loosening. At a mean of 36 months (range, 25–56 months), one patient died and one was lost to follow-up. There were no known cases of hip dislocation. There was one repeat revision, for a deep infection treated with irrigation and debridement. The mean preoperative Harris Hip Score of 46 (range, 40–79) improved to a mean of 65 points (range, 41–97) at the most recent evaluation. Acetabular components were retained in 8 out of 18 cases and the dual-mobility shell was cemented into it. Cementation of a dual-mobility cup into a shell at the time of a revision surgery is a safe and reliable construct at minimum of 2 years for patients at high risk of dislocation. There were no complications related to the cementation of the cup into the metal shell. Longer follow-up is required to further assess the durability of this construct.

Published
2018
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28. Error Control Coding Algorithms in High Reliability Telemetry Systems.

Author

Tyncherov, Kamil T., Mukhametshin, Vyacheslav Sh., Krasnobaev, Victor A., and Selivanova, Maria V.

Subjects
RELIABILITY in engineering, DIGITAL signal processing, LINEAR codes, INTELLIGENT networks, ALGORITHMS, PETROLEUM
Abstract

In the oil and gas industry, in the process of drilling support (geosteering) and well telemetry, there is a problem of transmitting reliable information via wireless communication channels. The quality of such communication, as a rule, suffers due to the presence of errors caused by interference. As the depth of the well increases, the problem becomes more extensive. In order to solve the problem, it is proposed to choose noise-resistant coding in the system of residual classes. This system parallelizes the execution of arithmetic operations, has corrective abilities and organically adapts to the neural network basis of intelligent field management. At the same time, there are constraining factors for the mass application of the RNS; for example, difficulties in implementing non-modular procedures, forward and reverse coding, and some difficulties in identifying and correcting errors. That is why the task of improving the RNS seems relevant not only for oil and gas complexes, but also for any digital signal processing applications focused on intelligent neural network management on the basis of non-positional computing. The material of the article is limited to the study of the noise immunity of linear codes of the deduction system and the development of algorithms for detecting and correcting errors. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Assessment of the Effectiveness of Rehabilitation after Total Knee Replacement Surgery Using Sample Entropy and Classical Measures of Body Balance

Author

Hadamus, Anna, primary, Białoszewski, Dariusz, additional, Błażkiewicz, Michalina, additional, Kowalska, Aleksandra J., additional, Urbaniak, Edyta, additional, Wydra, Kamil T., additional, Wiaderna, Karolina, additional, Boratyński, Rafał, additional, Kobza, Agnieszka, additional, and Marczyński, Wojciech, additional

Published
2021
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30. Postoperative Glycemic Variability and Adverse Outcomes After Posterior Cervical Fusion

Author

Patel, Parthik D., primary, Canseco, Jose A., additional, Wilt, Zachary, additional, Okroj, Kamil T., additional, Chang, Michael, additional, Reyes, Ariana A., additional, Bowles, Daniel R., additional, Kurd, Mark F., additional, Rihn, Jeffrey A., additional, Anderson, D. Greg, additional, Hilibrand, Alan S., additional, Kepler, Christopher K., additional, Vaccaro, Alexander R., additional, and Schroeder, Gregory D., additional

Published
2020
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31. Carga global, regional y nacional de neurológicas. Desórdenes, 1990-2016: un análisis sistemático para el Global Estudio de la carga de enfermedad 2016

Author

Feigin V, Nichols E, Alam T, Bannick M, Beghi E, Blake N, Culpepper W, Dorsey E, Elbaz A, Ellenbogen R, Fisher J, Fitzmaurice C, Giussani G, Glennie L, James S, Johnson C, Kassebaum N, Logroscino G, Marin B, Mountjoy-Venning W, Nguyen M, Ofori-Asenso R, Patel A, Piccininni M, Roth G, Steiner T, Stovner L, Szoeke C, Theadom A, Vollset S, Wallin M, Wright C, Zunt J, Abbasi N, Abd-Allah F, Abdelalim A, Abdollahpour I, Aboyans V, Abraha H, Acharya D, Adamu A, Adebayo O, Adeoye A, Adsuar J, Afarideh M, Agrawal S, Ahmadi A, Ahmed M, Aichour A, Aichour I, Aichour M, Akinyemi R, Akseer N, Al-Eyadhy A, Salman R, Alahdab F, Alene K, Aljunid S, Altirkawi K, Alvis-Guzman N, Anber N, Antonio C, Arabloo J, Aremu O, Arnlov J, Asayesh H, Asghar R, Atalay H, Awasthi A, Quintanilla B, Ayuk T, Badawi A, Banach M, Banoub J, Barboza M, Barker-Collo S, Barnighausen T, Baune B, Bedi N, Behzadifar M, Bejot Y, Bekele B, Belachew A, Bennett D, Bensenor I, Berhane A, Beuran M, Bhattacharyya K, Bhutta Z, Biadgo B, Bijani A, Bililign N, Bin Sayeed M, Blazes C, Brayne C, Butt Z, Campos-Nonato I, Cantu-Brito C, Car M, Cardenas R, Carrero J, Carvalho F, Castaneda-Orjuela C, Castro F, Catala-Lopez F, Cerin E, Chaiah Y, Chang J, Chatziralli I, Chiang P, Christensen H, Christopher D, Cooper C, Cortesi P, Costa V, Criqui M, Crowe C, Damasceno A, Daryani A, De la Cruz-Gongora V, De la Hoz F, De Leo D, Degefa M, Demoz G, Deribe K, Dharmaratne S, Diaz D, Dinberu M, Djalalinia S, Doku D, Dubey M, Dubljanin E, Duken E, Edvardsson D, El-Khatib Z, Endres M, Endries A, Eskandarieh S, Esteghamati A, Esteghamati S, Farhadi F, Faro A, Farzadfar F, Farzaei M, Fatima B, Fereshtehnejad S, Fernandes E, Feyissa G, Filip I, Fischer F, Fukumoto T, Ganji M, Gankpe F, Garcia-Gordillo M, Gebre A, Gebremichael T, Gelaw B, Geleijnse J, Geremew D, Gezae K, Ghasemi-Kasman M, Gidey M, Gill P, Gill T, Gnedovskaya E, Goulart A, Grada A, Grosso G, Guo Y, Gupta R, Haagsma J, Hagos T, Haj-Mirzaian A, Hamadeh R, Hamidi S, Hankey G, Hao Y, Haro J, Hassankhani H, Hassen H, Havmoeller R, Hay S, Hegazy M, Heidari B, Henok A, Heydarpour F, Hoang C, Hole M, Rad E, Hosseini S, Hu G, Igumbor E, Ilesanmi O, Irvani S, Islam S, Jakovljevic M, Javanbakht M, Jha R, Jobanputra Y, Jonas J, Jozwiak J, Jurisson M, Kahsay A, Kalani R, Kalkonde Y, Kamil T, Kanchan T, Karami M, Karch A, Karimi N, Kasaeian A, Kassa T, Kassa Z, Kaul A, Kefale A, Keiyoro P, Khader Y, Khafaie M, Khalil I, Khan E, Khang Y, Khazaie H, Kiadaliri A, Kiirithio D, Kim A, Kim D, Kim Y, Kisa A, Kokubo Y, Koyanagi A, Krishnamurthi R, Defo B, Bicer B, Kumar M, Lacey B, Lafranconi A, Lansingh V, Latifi A, Leshargie C, Li S, Liao Y, Linn S, Lo W, Lopez J, Lorkowski S, Lotufo P, Lucas R, Lunevicius R, Mackay M, Mahotra N, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Malta D, Manafi N, Mansournia M, Mantovani L, Marz W, Mashamba-Thompson T, Massenburg B, Mate K, McAlinden C, McGrath J, Mehta V, Meier T, Meles H, Melese A, Memiah P, Memish Z, Mendoza W, Mengistu D, Mengistu G, Meretoja A, Meretoja T, Mestrovic T, Miazgowski B, Miazgowski T, Miller T, Mini G, Mirrakhimov E, Moazen B, Mohajer B, Mezerji N, Mohammadi M, Mohammadi-Khanaposhtani M, Mohammadibakhsh R, Mohammadnia-Afrouzi M, Mohammed S, Mohebi F, Mokdad A, Monasta L, Mondello S, Moodley Y, Moosazadeh M, Moradi G, Moradi-Lakeh M, Moradinazar M, Moraga P, Velasquez I, Morrison S, Mousavi S, Muhammed O, Muruet W, Musa K, Mustafa G, Naderi M, Nagel G, Naheed A, Naik G, Najafi F, Nangia V, Negoi I, Negoi R, Newton C, Ngunjiri J, Nguyen C, Nguyen L, Ningrum D, Nirayo Y, Nixon M, Norrving B, Noubiap J, Shiadeh M, Nyasulu P, Ogbo F, Oh I, Olagunju A, Olagunju T, Olivares P, Onwujekwe O, Oren E, Owolabi M, Mahesh P, Pakpour A, Pan W, Panda-Jonas S, Pandian J, Patel S, Pereira D, Petzold M, Pillay J, Piradov M, Polanczyk G, Polinder S, Postma M, Poulton R, Poustchi H, Prakash S, Prakash V, Qorbani M, Radfar A, Rafay A, Rafiei A, Rahim F, Rahimi-Movaghar V, Rahman M, Rajati F, Ram U, Ranta A, 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Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Lee Kong Chian School of Medicine (LKCMedicine), Clinicum, Department of Neurosciences, Neurologian yksikkö, Department of Surgery, University of Helsinki, II kirurgian klinikka, and HUS Comprehensive Cancer Center

Subjects
Dánarmein, Male, Epidemiology, Diseases, Malalties cerebrals, Global Burden of Disease, Disability Evaluation, 0302 clinical medicine, Case fatality rate, Psychology, Konur, Cause of death, Aged, 80 and over, education.field_of_study, Incidence, Men, Taugavísindi, ddc, 3. Good health, Sálfræði, World health, Muerte, Neurology, GBD 2016 Neurology Collaborators, Brain diseases, Quality-Adjusted Life Years, Alzheimer disease, Carga global de enfermedades, Nervous system, medicine.medical_specialty, Global burden of diseases, Lífsgæði, Article, 03 medical and health sciences, Health Sciences, Humans, Women, education, Trastornos neurológicos, VLAG, Aged, Science & Technology, 3112 Neurosciences, Global Burden of Diseases, 030104 developmental biology, Years of potential life lost, Επιστήμες Υγείας, Dementia, Human medicine, Neurosciences & Neurology, Neurology (clinical), Clinical Medicine, 1109 Neurosciences, Neurological disorders, 030217 neurology & neurosurgery, dementia, RC, 0301 basic medicine, Pediatrics, Dánartíðni, Nutrition and Disease, 3124 Neurology and psychiatry, Disease Study, Taugasjúkdómar, Risk Factors, Voeding en Ziekte, Cause of Death, Global health, Prevalence, Causes of death, Public health, Mortality rate, Mental Disorders, Age Factors, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, neurologic disease, Death, Lýðheilsa, Female, Life Sciences & Biomedicine, Quality of life, Adult, Population, Clinical Neurology, Sex Factors, medicine, Life Science, Disability-adjusted life year, Medicine [Science], Mortality, Psychiatry, Disease burden, Neurology & Neurosurgery, burden of neurological disorders, Faraldsfræði, business.industry, Klinisk medicin, Causes de la mort, 1103 Clinical Sciences, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Socioeconomic Factors, Karlar, global disease burden, Nervous System Diseases, Cause of death/trends, business
Abstract

Publisher´s version (útgefin grein)., Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer’s disease and other dementias, Parkinson’s disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer’s and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer’s disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies., ROA is funded by the National Institutes of Health (U01HG010273). SMA acknowledges the International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia and Department of Health Policy and Management, Faculty of Public Health, Kuwait University for the approval and support to participate in this research project. AAw acknowledges funding support from Department of Science and Technology, Government of India, New Delhi, through INSPIRE Faculty scheme. TBA acknowledges partial funding from the Institute of Medical Research and Medicinal Plant Studies. ABa is supported by the Public Health Agency of Canada. TWB was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor Award, funded by the Federal Ministry of Education and Research. MSBS acknowledges support from the Australian Government Research and Training Program scholarship for a PhD degree at the Australian National University, Australia. JJC is supported by the Swedish Heart and Lung Foundation. FCar is supported by the European Union (FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) under the Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020UID/QUI/50006/2013. EC is supported by an Australian Research Council Future Fellowship (FT3 140100085). KD is supported by a Wellcome Trust [Grant Number 201900] as part of his International Intermediate Fellowship. EF is supported by the European Union (FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) under the Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020UID/QUI/50006/2013. SMSI is funded by the Institute for Physical Activity and Nutrition (IPAN), Deakin University and received funding from High Blood Pressure Research Council of Australia. YKa is a DBT/Wellcome Trust India Alliance Fellow in Public Health. YJK is supported by the Office of Research and Innovation at Xiamen University Malaysia. BL acknowledges funding from the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. WDL is supported in part by U10NS086484 NINDS. SLo is funded by the German Federal Ministry of Education and Research (nutriCARD, grant agreement number 01EA1411A). RML is supported by a National Health and Medical Research Council (NHMRC) of Australia Senior Research Fellowship. AMa and the Imperial College London are grateful for support from the NW London NIHR Collaboration for Leadership in Applied Health Research and Care. JJM is supported by the Danish National Research Foundation (Niels Bohr Professorship), and the John Cade Fellowship (APP1056929) from NHMRC. TMei acknowledges additional institutional support from the Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Jena-Halle-Leipzig. IMV is supported by the Sistema Nacional de Investigacion (Panama). MOO is supported by SIREN U54 U54HG007479 and SIBS Genomics R01NS107900 grants. AMS was supported by a fellowship from the Egyptian Fulbright Mission Program. MMSM acknowledges the support from the Ministry of Education, Science and Technological Development, Republic of Serbia (contract no 175087). AShe is supported by Health Data Research UK. MBS' work on traumatic brain injury is supported by grants NIH U01 NS086090 (PI G Manley) from the National Institutes of Health (NIH) and DoD W81XWH-14-2-0176 (PI G Manley) from the United States Department of Defense. RTS is supported in part by grant number PROMETEOII/2015/021 from Generalitat Valenciana and the national grant PI17/00719 from ISCIIIFEDER. AGT was supported by a Fellowship from the NHMRC (Australia; 1042600. KBT acknowledges funding supports from the Maurice Wilkins Centre for Biodiscovery, Cancer Society of New Zealand, Health Research Council, Gut Cancer Foundation, and the University of Auckland. CY acknowledges support from the National Natural Science Foundation of China (grant number 81773552) and the Chinese NSFC International Cooperation and Exchange Program (grant number 71661167007)., "Peer Reviewed"

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2019
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33. Estimating global injuries morbidity and mortality: Methods and data used in the Global Burden of Disease 2017 study

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James, S, Castle, C, Dingels, Z, Fox, J, Hamilton, E, Liu, Z, Roberts, N, Sylte, D, Bertolacci, G, Cunningham, M, Henry, N, Legrand, K, Abdelalim, A, Abdollahpour, I, Abdulkader, R, Abedi, A, Abegaz, K, Abosetugn, A, Abushouk, A, Adebayo, O, Adsuar, J, Advani, S, Agudelo-Botero, M, Ahmad, T, Ahmed, M, Ahmed, R, Eddine Aichour, M, Alahdab, F, Alanezi, F, Alema, N, Alemu, B, Alghnam, S, Ali, B, Ali, S, Alinia, C, Alipour, V, Aljunid, S, Almasi-Hashiani, A, Almasri, N, Altirkawi, K, Abdeldayem Amer, Y, Andrei, C, Ansari-Moghaddam, A, T Antonio, C, Anvari, D, Yaw Appiah, S, Arabloo, J, Arab-Zozani, M, Arefi, Z, Aremu, O, Ariani, F, Arora, A, Asaad, M, Ayala Quintanilla, B, Ayano, G, Ayanore, M, Azarian, G, Badawi, A, Badiye, A, Baig, A, Bairwa, M, Bakhtiari, A, Balachandran, A, Banach, M, Banerjee, S, Banik, P, Banstola, A, Barker-Collo, S, Bärnighausen, T, Barzegar, A, Bayati, M, Bazargan-Hejazi, S, Bedi, N, Behzadifar, M, Belete, H, Bennett, D, Bensenor, I, Berhe, K, Bhagavathula, A, 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Mehdi, Nagarajan, Ahamarshan Jayaraman, Naik, Gurudatta, Naimzada, Mukhammad David, Najafi, Farid, Nangia, Vinay, Nascimento, Bruno Ramos, Naserbakht, Morteza, Nayak, Vinod, Nazari, Javad, Ndwandwe, Duduzile Edith, Negoi, Ionut, Ngunjiri, Josephine W, Nguyen, Trang Huyen, Nguyen, Cuong Tat, Nguyen, Diep Ngoc, Thi Nguyen, Huong Lan, Nikbakhsh, Rajan, Anggraini Ningrum, Dina Nur, Nnaji, Chukwudi A, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Oghenetega, Onome Bright, Oh, In-Hwan, Olagunju, Andrew T, Olagunju, Tinuke O, Bali, Ahmed Omar, Onwujekwe, Obinna E, Orpana, Heather M, Ota, Erika, Otstavnov, Nikita, Otstavnov, Stanislav S, P A, Mahesh, Padubidri, Jagadish Rao, Pakhale, Smita, Pakshir, Keyvan, Panda-Jonas, Songhomitra, Park, Eun-Kee, Patel, Sangram Kishor, Pathak, Ashish, Pati, Sanghamitra, Paulos, Kebreab, Peden, Amy E, Filipino Pepito, Veincent Christian, Pereira, Jeevan, Phillips, Michael R, Polibin, Roman V, Polinder, Suzanne, Pourmalek, Farshad, Pourshams, Akram, Poustchi, Hossein, Prakash, Swayam, Angga Pribadi, Dimas Ria, Puri, Parul, Syed, Zahiruddin Quazi, Rabiee, Navid, Rabiee, Mohammad, Radfar, Amir, Rafay, Anwar, Rafiee, Ata, Rafiei, Alireza, Rahim, Fakher, Rahimi, Siavash, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Rakovac, Ivo, Rao, Sowmya J, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Renjith, Vishnu, Resnikoff, Serge, Rezapour, Aziz, Ribeiro, Ana Isabel, Rickard, Jennifer, Rios González, Carlos Miguel, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Saddik, Basema, Safarpour, Hamid, Safdarian, Mahdi, Salamati, Payman, Rashad Salem, Marwa R, Salem, Hosni, Salz, Inbal, Samy, Abdallah M, Sanabria, Juan, Riera, Lidia Sanchez, Santric Milicevic, Milena M, Sarker, Abdur Razzaque, Sarveazad, Arash, Sathian, Brijesh, Sawhney, Monika, Sayyah, Mehdi, Schwebel, David C, Seedat, Soraya, Senthilkumaran, Subramanian, Seyedmousavi, Seyedmojtaba, Sha, Feng, Shaahmadi, Faramarz, Shahabi, Saeed, Shaikh, Masood Ali, Shams-Beyranvand, Mehran, Sheikh, Aziz, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Siabani, Soraya, Sigfusdottir, Inga Dora, Singh, Jasvinder A, Singh, Pankaj Kumar, Sinha, Dhirendra Narain, Soheili, Amin, Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Stokes, Mark A, Sufiyan, Mu'awiyyah Babale, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Taddele, Biruk Wogayehu, Tefera, Yonatal Mesfin, Tehrani-Banihashemi, Arash, Tekulu, Gebretsadkan Hintsa, Tesema Tesema, Ayenew Kassie, Tesfay, Berhe Etsay, Thapar, Rekha, Titova, Mariya Vladimirovna, Tlaye, Kenean Getaneh, Tohidinik, Hamid Reza, Topor-Madry, Roman, Tran, Khanh Bao, Tran, Bach Xuan, Tripathy, Jaya Prasad, Tsai, Alexander C, Tsatsakis, Aristidis, Car, Lorainne Tudor, Ullah, Irfan, Ullah, Saif, Unnikrishnan, Bhaskaran, Upadhyay, Era, Uthman, Olalekan A, Valdez, Pascual R, Vasankari, Tommi Juhani, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasily, Waheed, Yasir, Wang, Yuan-Pang, Wiangkham, Taweewat, Wolde, Haileab Fekadu, Woldeyes, Dawit Habte, Wondmeneh, Temesgen Gebeyehu, Wondmieneh, Adam Belay, Wu, Ai-Min, Wyper, Grant M A, Yadav, Rajaram, Yadollahpour, Ali, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Ye, Pengpeng, Yip, Paul, Yisma, Engida, Yonemoto, Naohiro, Yoon, Seok-Jun, Youm, Yoosik, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Moghadam, Telma Zahirian, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zandian, Hamed, Zarei, Fatemeh, Zhang, Zhi-Jiang, Zhang, Yunquan, Ziapour, Arash, Zodpey, Sanjay, Dandona, Rakhi, Dharmaratne, Samath Dhamminda, Hay, Simon I, Mokdad, Ali H, Pigott, David M, Reiner, Robert C, and Vos, Theo

Abstract

Background: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results: GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions: GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future.

Published
2020

34. Oral and Intravenous Tranexamic Acid Are Equivalent at Reducing Blood Loss Following Total Hip Arthroplasty

Author

Erdan Kayupov, Tad L. Gerlinger, Yale A. Fillingham, Craig J. Della Valle, Mario Moric, Kamil T. Okroj, and Darren R. Plummer

Subjects
Male, medicine.medical_specialty, Antifibrinolytic, Randomization, medicine.drug_class, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Blood Loss, Surgical, Administration, Oral, Postoperative Hemorrhage, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Antifibrinolytic agent, Humans, Medicine, Orthopedics and Sports Medicine, Perioperative Period, Aged, 030222 orthopedics, business.industry, General Medicine, Perioperative, Middle Aged, Arthroplasty, Antifibrinolytic Agents, Surgery, Tranexamic Acid, Anesthesia, Administration, Intravenous, Female, Hemoglobin, business, Tranexamic acid, medicine.drug
Abstract

BACKGROUND Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss and the need for transfusions when administered intravenously in total hip arthroplasty. Oral formulations of the drug are available at a fraction of the cost of the intravenous preparation. The purpose of this randomized controlled trial was to determine if oral and intravenous formulations of tranexamic acid have equivalent blood-sparing properties. METHODS In this double-blinded trial, 89 patients undergoing primary total hip arthroplasty were randomized to receive 1.95 g of tranexamic acid orally 2 hours preoperatively or a 1-g tranexamic acid intravenous bolus in the operating room prior to incision; 6 patients were eventually excluded for protocol deviations, leaving 83 patients available for study. The primary outcome was the reduction of hemoglobin concentration. Power analysis determined that 28 patients were required in each group with a ±1.0 g/dL hemoglobin equivalence margin between groups with an alpha of 5% and a power of 80%. Equivalence analysis was performed with a two one-sided test (TOST) in which a p value of

Published
2017
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35. Utilizing the Time Trade-Off, Standard Gamble, and Willingness to Pay Utility Measures to Evaluate Health-Related Quality of Life Prior to Knee or Hip Arthroplasty

Author

Chris Culvern, Brian Darrith, Craig J. Della Valle, Tyler E. Calkins, Kamil T. Okroj, and Roman Drabchuk

Subjects
Knee arthritis, Adult, Male, Risk, medicine.medical_specialty, Arthroplasty, Replacement, Hip, Health Status, Time-trade-off, 03 medical and health sciences, 0302 clinical medicine, Life Expectancy, Acquired immunodeficiency syndrome (AIDS), Quality of life, Willingness to pay, medicine, Humans, Orthopedics and Sports Medicine, Myocardial infarction, Patient Reported Outcome Measures, Arthroplasty, Replacement, Knee, Aged, 030222 orthopedics, business.industry, Middle Aged, Osteoarthritis, Knee, medicine.disease, Life expectancy, Physical therapy, Quality of Life, Female, business, Body mass index
Abstract

Background Time trade-off, standard gamble, and willingness to pay assess the number of years, risk of death, and income a patient would give up for perfect health. These questions were used to evaluate the impact knee arthritis, hip arthritis, or failed total knee (TKA) or hip arthroplasty (THA) has on patients’ health-related quality of life prior to surgery. Methods Three hundred sixty patients including 176 undergoing primary TKA, 127 undergoing primary THA, 31 undergoing revision TKA, and 26 undergoing revision THA were assessed. Time trade-off and standard gamble were converted to utility scores with 1.0 suggesting perfect health and 0 suggesting preference for death rather than living in current state. Willingness to pay is the percentage of yearly income that a patient would pay for perfect health. Results The mean time trade-off, standard gamble, and willingness to pay scores were 0.74, 0.83, and 0.32 without significant difference between procedures with the numbers available for study (P = .16, .31, and 0.41, respectively). Increasing body mass index was correlated with decreasing time trade-off scores (P = .014). Conclusion Patients scheduled for primary or revision THA and TKA would accept an average 17% risk of death, lose 2.6 years of an additional 10-year life expectancy, and pay 32% of their income for perfect health. The time trade-off (0.74) was similar to patients with history of acute myocardial infarction (0.74) or minor stroke (0.72) and worse than those with chronic hepatitis C (0.83) or human immunodeficiency virus/acquired immunodeficiency syndrome infection (0.86). These data highlight the high value that patients place on adult reconstructive procedures.

Published
2018

37. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Feigin, V, Nichols, E, Alam, T, Bannick, M, Beghi, E, Blake, N, Culpepper, W, Dorsey, E, Elbaz, A, Ellenbogen, R, Fisher, J, Fitzmaurice, C, Giussani, G, Glennie, L, James, S, Johnson, C, Kassebaum, N, Logroscino, G, Marin, B, Mountjoy-Venning, W, Nguyen, M, Ofori-Asenso, R, Patel, A, Piccininni, M, Roth, G, Steiner, T, Stovner, L, Szoeke, C, Theadom, A, Vollset, S, Wallin, M, Wright, C, Zunt, J, Abbasi, N, Abd-Allah, F, Abdelalim, A, Abdollahpour, I, Aboyans, V, Abraha, H, Acharya, D, Adamu, A, Adebayo, O, Adeoye, A, Adsuar, J, Afarideh, M, Agrawal, S, Ahmadi, A, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Akinyemi, R, Akseer, N, Al-Eyadhy, A, Al-Shahi Salman, R, Alahdab, F, Alene, K, Aljunid, S, Altirkawi, K, Alvis-Guzman, N, Anber, N, Antonio, C, Arabloo, J, Aremu, O, Ärnlöv, J, Asayesh, H, Asghar, R, Atalay, H, Awasthi, A, Ayala Quintanilla, B, Ayuk, T, Badawi, A, Banach, M, Banoub, J, Barboza, M, Barker-Collo, S, Bärnighausen, T, Baune, B, Bedi, N, Behzadifar, M, Béjot, Y, 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Taylor, Wright, Claire, Zunt, Joseph Raymond, Abbasi, Nooshin, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Aboyans, Victor, Abraha, Haftom Niguse, Acharya, Dilaram, Adamu, Abdu A, Adebayo, Oladimeji M, Adeoye, Abiodun Moshood, Adsuar, Jose C, Afarideh, Mohsen, Agrawal, Sutapa, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Eyadhy, Ayman, Al-Shahi Salman, Rustam, Alahdab, Fares, Alene, Kefyalew Addis, Aljunid, Syed Mohamed, Altirkawi, Khalid, Alvis-Guzman, Nelson, Anber, Nahla Hamed, Antonio, Carl Abelardo T, Arabloo, Jalal, Aremu, Olatunde, Ärnlöv, Johan, Asayesh, Hamid, Asghar, Rana Jawad, Atalay, Hagos Tasew, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayuk, Tambe B, Badawi, Alaa, Banach, Maciej, Banoub, Joseph Adel Mattar, Barboza, Miguel A, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Baune, Bernhard T, Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Béjot, Yannick, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Bennett, Derrick A, Bensenor, Isabela M, Berhane, Adugnaw, Beuran, Mircea, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Biadgo, Belete, Bijani, Ali, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Blazes, Christopher Kynrint, Brayne, Carol, Butt, Zahid A, Campos-Nonato, Ismael R, Cantu-Brito, Carlos, Car, Mate, Cárdenas, Rosario, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castro, Franz, Catalá-López, Ferrán, Cerin, Ester, Chaiah, Yazan, Chang, Jung-Chen, Chatziralli, Irini, Chiang, Peggy Pei-Chia, Christensen, Hanne, Christopher, Devasahayam J, Cooper, Cyrus, Cortesi, Paolo Angelo, Costa, Vera M, Criqui, Michael H, Crowe, Christopher Stephen, Damasceno, Albertino Antonio Moura, Daryani, Ahmad, De la Cruz-Góngora, Vanessa, De la Hoz, Fernando Pio, De Leo, Diego, Demoz, Gebre Teklemariam, Deribe, Kebede, Dharmaratne, Samath Dhamminda, Diaz, Daniel, Dinberu, Mesfin Tadese, Djalalinia, Shirin, Doku, David Teye, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Edvardsson, David, El-Khatib, Ziad, Endres, Matthias, Endries, Aman Yesuf, Eskandarieh, Sharareh, Esteghamati, Alireza, Esteghamati, Sadaf, Farhadi, Farzaneh, Faro, Andre, Farzadfar, Farshad, Farzaei, Mohammad Hosein, Fatima, Batool, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fukumoto, Takeshi, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Garcia-Gordillo, Miguel A, Gebre, Abadi Kahsu, Gebremichael, Teklu Gebrehiwo, Gelaw, Belayneh K, Geleijnse, Johanna M, Geremew, Demeke, Gezae, Kebede Embaye, Ghasemi-Kasman, Maryam, Gidey, Mahari Y, Gill, Paramjit Singh, Gill, Tiffany K, Girma, Efrata Tufa, Gnedovskaya, Elena V, Goulart, Alessandra C, Grada, Ayman, Grosso, Giuseppe, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Haagsma, Juanita A, Hagos, Tekleberhan B, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randah R, Hamidi, Samer, Hankey, Graeme J, Hao, Yuantao, Haro, Josep Maria, Hassankhani, Hadi, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Simon I, Hegazy, Mohamed I, Heidari, Behnam, Henok, Andualem, Heydarpour, Fatemeh, Hoang, Chi Linh, Hole, Michael K, Homaie Rad, Enayatollah, Hosseini, Seyed Mostafa, Hu, Guoqing, Igumbor, Ehimario U, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jakovljevic, Mihajlo, Javanbakht, Mehdi, Jha, Ravi Prakash, Jobanputra, Yash B, Jonas, Jost B, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kahsay, Amaha, Kalani, Rizwan, Kalkonde, Yogeshwar, Kamil, Teshome Abegaz, Kanchan, Tanuj, Karami, Manoochehr, Karch, André, Karimi, Narges, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kassa, Zemenu Yohannes, Kaul, Anil, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khang, Young-Ho, Khazaie, Habibolah, Kiadaliri, Aliasghar A, Kiirithio, Daniel N, Kim, Anthony S, Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kisa, Adnan, Kokubo, Yoshihiro, Koyanagi, Ai, Krishnamurthi, Rita V, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kumar, Manasi, Lacey, Ben, Lafranconi, Alessandra, Lansingh, Van C, Latifi, Arman, Leshargie, Cheru Tesema, Li, Shanshan, Liao, Yu, Linn, Shai, Lo, Warren David, Lopez, Jaifred Christian F, Lorkowski, Stefan, Lotufo, Paulo A, Lucas, Robyn M, Lunevicius, Raimundas, Mackay, Mark T, Mahotra, Narayan Bahadur, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manafi, Navid, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, März, Winfried, Mashamba-Thompson, Tivani Phosa, Massenburg, Benjamin Ballard, Mate, Kedar K V, McAlinden, Colm, McGrath, John J, Mehta, Varshil, Meier, Toni, Meles, Hagazi Gebre, Melese, Addisu, Memiah, Peter T N, Memish, Ziad A, Mendoza, Walter, Mengistu, Desalegn Tadese, Mengistu, Getnet, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Mini, G. K., Mirrakhimov, Erkin M, Moazen, Babak, Mohajer, Bahram, Mohammad Gholi Mezerji, Naser, Mohammadi, Moslem, Mohammadi-Khanaposhtani, Maryam, Mohammadibakhsh, Roghayeh, Mohammadnia-Afrouzi, Mousa, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Mondello, Stefania, Moodley, Yoshan, Moosazadeh, Mahmood, Moradi, Ghobad, Moradi-Lakeh, Maziar, Moradinazar, Mehdi, Moraga, Paula, Moreno Velásquez, Ilais, Morrison, Shane Douglas, Mousavi, Seyyed Meysam, Muhammed, Oumer Sada, Muruet, Walter, Musa, Kamarul Imran, Mustafa, Ghulam, Naderi, Mehdi, Nagel, Gabriele, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Negoi, Ionut, Negoi, Ruxandra Irina, Newton, Charles Richard James, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Nguyen, Long Hoang, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nixon, Molly R, Norrving, Bo, Noubiap, Jean Jacques, Nourollahpour Shiadeh, Malihe, Nyasulu, Peter S, Ogah, Okechukwu Samuel, Oh, In-Hwan, Olagunju, Andrew T, Olagunju, Tinuke O, Olivares, Pedro R, Onwujekwe, Obinna E, Oren, Eyal, Owolabi, Mayowa Ojo, PA, Mahesh, Pakpour, Amir H, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Pandian, Jeyaraj Durai, Patel, Sangram Kishor, Pereira, David M, Petzold, Max, Pillay, Julian David, Piradov, Michael A, Polanczyk, Guilherme V, Polinder, Suzanne, Postma, Maarten J, Poulton, Richie, Poustchi, Hossein, Prakash, Swayam, Prakash, V., Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rajati, Fatemeh, Ram, Usha, Ranta, Anna, Rawaf, David Laith, Rawaf, Salman, Reinig, Nickolas, Reis, Cesar, Renzaho, Andre M N, Resnikoff, Serge, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Rios González, Carlos Miguel, Roberts, Nicholas L S, Roever, Leonardo, Ronfani, Luca, Roro, Elias Merdassa, Roshandel, Gholamreza, Rostami, Ali, Sabbagh, Parisa, Sacco, Ralph L, Sachdev, Perminder S, Saddik, Basema, Safari, Hosein, Safari-Faramani, Roya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salamati, Payman, Salehi Zahabi, Saleh, Salimi, Yahya, Samy, Abdallah M, Sanabria, Juan, Santos, Itamar S, Santric Milicevic, Milena M, Sarrafzadegan, Nizal, Sartorius, Benn, Sarvi, Shahabeddin, Sathian, Brijesh, Satpathy, Maheswar, Sawant, Arundhati R, Sawhney, Monika, Schneider, Ione J C, Schöttker, Ben, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Shabaninejad, Hosein, Shafieesabet, Azadeh, Shaikh, Masood Ali, Shakir, Raad A, Shams-Beyranvand, Mehran, Shamsizadeh, Morteza, Sharif, Mehdi, Sharif-Alhoseini, Mahdi, She, Jun, Sheikh, Aziz, Sheth, Kevin N, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Siabani, Soraya, Siddiqi, Tariq J, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silberberg, Donald H, Silva, João Pedro, Silveira, Dayane Gabriele Alves, Singh, Jasvinder A, Sinha, Dhirendra Narain, Skiadaresi, Eirini, Smith, Mari, Sobaih, Badr Hasan, Sobhani, Soheila, Soofi, Moslem, Soyiri, Ireneous N, Sposato, Luciano A, Stein, Dan J, Stein, Murray B, Stokes, Mark A, Sufiyan, Mu'awiyyah Babale, Sykes, Bryan L, Sylaja, P. N., Tabarés-Seisdedos, Rafael, Te Ao, Braden James, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Temsah, Omar, Thakur, Jarnail Singh, Thrift, Amanda G, Topor-Madry, Roman, Tortajada-Girbés, Miguel, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tran, Khanh Bao, Truelsen, Thomas Clement, Tsadik, Afewerki Gebremeskel, Tudor Car, Lorainne, Ukwaja, Kingsley Nnanna, Ullah, Irfan, Usman, Muhammad Shariq, Uthman, Olalekan A, Valdez, Pascual R, Vasankari, Tommi Juhani, Vasanthan, Rajagopalan, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasily, Vosoughi, Kia, Vu, Giang Thu, Vujcic, Isidora S, Wagnew, Fasil Shiferaw, Waheed, Yasir, Wang, Yuan-Pang, Weiderpass, Elisabete, Weiss, Jordan, Whiteford, Harvey A, Wijeratne, Tissa, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Wolfe, Charles D A, Xu, Gelin, Yadollahpour, Ali, Yamada, Tomohide, Yano, Yuichiro, Yaseri, Mehdi, Yatsuya, Hiroshi, Yimer, Ebrahim M, Yip, Paul, Yisma, Engida, Yonemoto, Naohiro, Yousefifard, Mahmoud, Yu, Chuanhua, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zandian, Hamed, Zare, Zohreh, Zhang, Yunquan, Zodpey, Sanjay, Naghavi, Mohsen, Murray, Christopher J L, and Vos, Theo

Abstract

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·

Published
2019

38. Nephrotoxicity After the Treatment of Periprosthetic Joint Infection With Antibiotic-Loaded Cement Spacers

Author

Kamil T. Okroj, Thea Rogers, Craig J. Della Valle, Scott M. Sporer, and Adam I. Edelstein

Subjects
Male, Reoperation, medicine.medical_specialty, Prosthesis-Related Infections, medicine.medical_treatment, Arthroplasty, Replacement, Hip, Renal function, Periprosthetic, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Vancomycin, Internal medicine, Medicine, Humans, Orthopedics and Sports Medicine, Rifle, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Arthroplasty, Replacement, Knee, Aged, Aged, 80 and over, 030222 orthopedics, Creatinine, Arthritis, Infectious, urogenital system, business.industry, Incidence, Acute kidney injury, Acute Kidney Injury, Middle Aged, medicine.disease, Arthroplasty, Anti-Bacterial Agents, chemistry, Tobramycin, Female, Illinois, Gentamicins, business, Kidney disease
Abstract

Background Treatment of periprosthetic joint infections commonly involves insertion of an antibiotic-loaded cement spacer (ACS). The risk for acute kidney injury (AKI) related to use of antibiotic spacers has not been well defined. We aimed to identify the incidence of and risk factors for AKI after placement of an ACS. Methods We performed a prospective cohort study of patients with an infected primary total hip or knee arthroplasty treated with ACSs with vancomycin, gentamicin, and tobramycin. Serum creatinine and glomerular filtration rate data were collected at baseline and weekly intervals for 8 weeks. Patients were classified into Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE) stages to determine incidence of AKI. Risk factors for kidney injury were identified via regression analysis. Results A total of 37 patients (20 total knee arthroplasty and 17 total hip arthroplasty) were included. During the 8 weeks after ACS placement, 10 patients (27%) fit RIFLE criteria for kidney injury and 2 patients (5%) fit RIFLE criteria for kidney failure. No baseline patient characteristics were associated with development of AKI. Conclusion Patients should be monitored closely for development of AKI after placement of ACSs for the treatment of periprosthetic joint infection. Further research into minimizing risk for AKI is warranted.

Published
2017

39. Poor Outcomes of Irrigation and Debridement in Acute Periprosthetic Joint Infection With Antibiotic-Impregnated Calcium Sulfate Beads

Author

Craig J. Della Valle, Bryan D. Springer, Brett R. Levine, Kamil T. Okroj, Michael A. Flierl, and Brian M. Culp

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Staphylococcus aureus, Prosthesis-Related Infections, medicine.drug_class, medicine.medical_treatment, Arthroplasty, Replacement, Hip, 030106 microbiology, Antibiotics, Periprosthetic, Therapeutic irrigation, Staphylococcal infections, Calcium Sulfate, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Medicine, Humans, Orthopedics and Sports Medicine, Postoperative Period, Prosthesis-Related Infection, Arthroplasty, Replacement, Knee, Therapeutic Irrigation, Aged, Retrospective Studies, Aged, 80 and over, 030222 orthopedics, Arthritis, Infectious, Debridement, business.industry, Retrospective cohort study, Middle Aged, Staphylococcal Infections, medicine.disease, Surgery, Anti-Bacterial Agents, Treatment Outcome, Acute Disease, Female, Implant, business
Abstract

Background One proposed strategy to increase the success of irrigation and debridement with implant retention for the treatment of acute periprosthetic joint infection (PJI) is the use of dissolvable antibiotic-impregnated calcium sulfate beads to provide a local depot of antibiotics. The purpose of this study was to evaluate the outcome of such an approach. Methods Thirty-two patients with acute hematogenous (18 patients; 1 bilateral) or acute postoperative (14 patients) PJIs who underwent irrigation and debridement with implant retention and addition of antibiotic-impregnated calcium sulfate beads were retrospectively reviewed. PJI followed 27 total knee arthroplasties and 6 total hip arthroplasties. The most common infecting organisms were methicillin-sensitive Staphylococcus aureus (13 of 33) and Streptococcus (9 of 33). The primary outcome parameter was recurrence of infection according to the Musculoskeletal Infection Society criteria. Patients were followed up for a minimum of 3 months or until failure. Results At a mean of 12.7 months (range, 3-30 months), 16 of the 33 patients failed (48%). Acute hematogenous and acute postoperative PJI had similar failure rates at 47% and 50%, respectively ( P = .88). Seven failures required a 2-stage exchange, while 8 patients were treated with chronic antibiotic suppression, being unwilling or unable to undergo further surgical intervention. Conclusion The addition of antibiotic-impregnated calcium sulfate beads does not appear to improve outcomes of irrigation and debridement with implant retention in the setting of acute hematogenous or acute postoperative PJI. Given the short follow-up in this report, this represents a best-case scenario and the overall failure rate may be higher with further follow-up.

Published
2016

40. The Mark Coventry, MD, Award: Oral Antibiotics Reduce Reinfection After Two-Stage Exchange: A Multicenter, Randomized Controlled Trial

Author

Katherine A. Belden, Javad Parvizi, John Segreti, Mario Moric, Jonathan M. Frank, Randi Silibovsky, Curtis W. Hartman, Brian Roslund, Craig J. Della Valle, Kamil T. Okroj, Erik N. Hansen, and Erdan Kayupov

Subjects
musculoskeletal diseases, Male, Reoperation, Recurrent infections, medicine.medical_specialty, Prosthesis-Related Infections, Sports medicine, medicine.drug_class, medicine.medical_treatment, Arthroplasty, Replacement, Hip, Antibiotics, Awards and Prizes, Periprosthetic, Administration, Oral, law.invention, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Randomized controlled trial, law, Recurrence, Secondary Prevention, Medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Stage (cooking), Arthroplasty, Replacement, Knee, Aged, 030222 orthopedics, Symposium: 2016 Knee Society Proceedings, business.industry, General Medicine, Middle Aged, Arthroplasty, Surgery, Anti-Bacterial Agents, Treatment Outcome, Orthopedic surgery, Female, business
Abstract

Many patients develop recurrent periprosthetic joint infection after two-stage exchange arthroplasty of the hip or knee. One potential but insufficiently tested strategy to decrease the risk of persistent or recurrent infection is to administer additional antibiotics after the second-stage reimplantation.(1) Does a 3-month course of oral antibiotics decrease the risk of failure secondary to infection after a two-stage exchange? (2) Are there any complications related to the administration of oral antibiotics after a two-stage exchange? (3) In those patients who develop a reinfection, is the infecting organism different from the initial infection?Patients at seven centers randomized to receive 3 months of oral antibiotics or no further antibiotic treatment after operative cultures after the second-stage reimplantation were negative. Adult patients undergoing two-stage hip or knee revision arthroplasty for a periprosthetic infection who met Musculoskeletal Infection Society (MSIS) criteria for infection at the first stage were included. Oral antibiotic therapy was tailored to the original infecting organism(s) in consultation with an infectious disease specialist. MSIS criteria as used by the treating surgeon defined failure. Surveillance of patients for complications, including reinfection, occurred at 3 weeks, 6 weeks, 3 months, 12 months, and 24 months. If an organism demonstrated the same antibiotic sensitivities as the original organism, it was considered the same organism; no DNA subtyping was performed. Analysis was performed as intent to treat with all randomized patients included in the groups to which they were randomized. A log-rank survival curve was used to analyze the primary outcome of reinfection. At planned interim analysis (enrollment is ongoing), 59 patients were successfully randomized to the antibiotic group and 48 patients to the control group. Fifty-seven patients had an infection after TKA and 50 after a THA. There was no minimum followup for inclusion in this analysis. The mean followup was 14 months in the antibiotic group and 10 months in the control group.Patients treated with oral antibiotics failed secondary to infection less frequently than those not treated with antibiotics (5% [three of 59] versus 19% [nine of 48]; hazard ratio, 4.37; 95% confidence interval, 1.297-19.748; p = 0.016). Three patients had an adverse reaction to the oral antibiotics severe enough to cause them to stop taking the antibiotics early, and four patients who were randomized to that group did not take the antibiotics as directed. With the numbers available, there were no differences between the study groups in terms of the likelihood that an infection after treatment would be with a new organism (eight of nine in the control group versus one of three in the treatment group, p = 0.087).This multicenter randomized trial suggests that at short-term followup, the addition of 3 months of oral antibiotics appeared to improve infection-free survival. As a planned interim analysis, however, these results may change as the study reaches closure and the safety profile may yet prove risky. Further followup of this cohort of patients will be necessary to determine whether these preliminary results are durable over time.Level I, therapeutic study.

Published
2016

41. Continuous Adductor Canal Blocks Provide Superior Ambulation and Pain Control Compared to Epidural Analgesia for Primary Knee Arthroplasty: A Randomized, Controlled Trial

Author

Craig J. Della Valle, Erdan Kayupov, Adam Young, Asokumar Buvanendran, Gilat Zisman, Timothy J. Luchetti, Mario Moric, Tad L. Gerlinger, and Kamil T. Okroj

Subjects
030222 orthopedics, medicine.medical_specialty, Randomization, Adductor canal, business.industry, medicine.medical_treatment, Thigh, Interim analysis, Arthroplasty, law.invention, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Femoral nerve, Randomized controlled trial, 030202 anesthesiology, law, Anesthesia, medicine, Nerve block, Orthopedics and Sports Medicine, business
Abstract

Background Adductor canal blocks (ACBs) are an alternative to femoral nerve blocks that minimize lower extremity weakness. However, it is unclear whether this block will provide analgesia that is equivalent to techniques, such as epidural analgesia. The purpose of this randomized controlled trial was to compare continuous ACBs with epidural analgesia for primary total knee arthroplasty. Methods Following institutional review board approval, 145 patients were randomized to 1 of 3 groups: combined spinal-epidural (CSE), spinal + continuous ACB (CACB), or general + CACB. Epidural analgesia was used postoperatively in the CSE group, and an adductor canal catheter was used in the CACB groups. Power analysis determined that 84 patients per group were needed to demonstrate a 35% increase in ambulation with an alpha of 0.05 at a power of 90%. Results At interim analysis, 13 patients were removed for protocol deviations, leaving 45 in CSE, 41 in spinal + CACB and 46 in general + CACB groups. Patient demographics were similar in all comparisons suggesting appropriate randomization. Patients in the CACB groups walked further on postoperative day 1, 2, and 3 ( P = .02). Mean daily pain scores were lower in the CACB groups (4.1 CSE, 3.0 spinal + CACB, 3.4 general + CACB, P = .009). There was no significant difference in total opioid consumption between groups (158 morphine equivalents CSE, 149 spinal + CACB, and 172 general + CACB). More patients reported being “very satisfied” in CACB groups (68% general + CACB, 63% spinal + CACB, and 36% CSE; P = .001). Conclusion Continuous adductor analgesia provides superior ambulation, lower pain scores, faster discharge, and greater patient satisfaction when compared to epidural analgesia for primary total knee arthroplasty.

Published
2018
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42. Periprosthetic Joint Infection After Hip and Knee Arthroplasty: A Review for Emergency Care Providers

Author

Tyler A. Luthringer, Craig J. Della Valle, Yale A. Fillingham, Edward Ward, and Kamil T. Okroj

Subjects
medicine.medical_specialty, Emergency Medical Services, Prosthesis-Related Infections, medicine.medical_treatment, Arthroplasty, Replacement, Hip, Periprosthetic, Physical examination, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Synovial Fluid, Medicine, Humans, 030212 general & internal medicine, Prosthesis-Related Infection, Arthroplasty, Replacement, Knee, 030222 orthopedics, medicine.diagnostic_test, business.industry, Arthrocentesis, Emergency department, medicine.disease, Arthroplasty, Surgery, Erythrocyte sedimentation rate, Emergency Medicine, business, Biomarkers
Abstract

Periprosthetic joint infection is among the most common modes of failure of a total hip or knee arthroplasty and can be a common concern when patients present to the emergency department for care. The initial evaluation for periprosthetic joint infection includes a history and physical examination, followed by radiographs (to rule out other causes of pain or failure) and then serum erythrocyte sedimentation rate and C-reactive protein testing. If the erythrocyte sedimentation rate and C-reactive protein level are elevated or if the clinical suspicion for infection is high, the joint should be aspirated and the fluid sent for culture, as well as for a synovial WBC count and differential, with optimal threshold values of 3,000 WBC/μL and 80% polymorphonuclear cells, respectively. Recent work has shown that optimal cutoff values for patients presenting in the early postoperative period (within the first 6 weeks postoperatively) are different, with a C-reactive protein level greater than or near 100 mg/L (normal

Published
2015

43. Estimation of the required collector area of a solar assisted heat pump

Author

Saad D. Oda, Kamil T. Al-Murrani, and Muthana K. Al-Doory

Subjects
Engineering, Meteorology, business.industry, Nuclear engineering, Hybrid heat, General Engineering, Coefficient of performance, law.invention, Photovoltaic thermal hybrid solar collector, General Energy, Thermal radiation, law, Exergy efficiency, Thermosiphon, business, Evaporator, Heat pump
Abstract

The solar assisted heat pump represents a method of increasing the heat pump COP by transferring solar radiation heat to the heat pump evaporator. In this paper a method of calculating the minimum design limit for the collector area based on the second law efficiency is introduced by using a set of experimental data on a certain design of a solar assisted heat pump system during winter time. A comparative study is made between the actual and ideal conditions, and a minimum required area of the collector is suggested.

Published
1991
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44. Revolution or realism? United States-Iran relations in the post-Cold War era

Author

Magnus, Ralph H., Said, Kamil T., Naval Postgraduate School, National Security Affairs (NSA), Woodyard, Bruce Leroy, Magnus, Ralph H., Said, Kamil T., Naval Postgraduate School, National Security Affairs (NSA), and Woodyard, Bruce Leroy

Abstract

The end of the Cold War has caused the emergence of regional conflicts and a lack of focus in United States foreign policy. This situation, has resulted in a newly confrontational stance with Tehran, manifested by an American policy of containment of the Islamic Republic. However, this portrayal of Iran as a pervasive threat to American interests is a mistake. This study offers an historical analysis of Iran's foreign policy interests and strategic outlook, a discussion of the dynamics of the Islamic Republic, and a history of United States-Iran relations. Strategic concerns have always dominated this relationship, and this continues to be so today. With the Soviet collapse and the defeat of Iraq, an altered and delicate balance of power exists in Southwest Asia. Iran's strategic importance has thus increased. Furthermore, Tehran must pursue moderation for a variety of reasons. The author concludes that the United States and Iran share both strategic and economic interests. America should pursue these shared interests from its current position of strength and gain Iran's cooperation on important issues. United States engagement with Iran would strengthen the pragmatic elements in the government, foster economic development and improve the security and stability of the region. Iran, Persian/Arabian Gulf, Middle East, Iranian revolution, Islamic ideology, Foreign policy, http://archive.org/details/revolutionorreal00wood, Lieutenant Commander, United States Navy, Approved for public release; distribution is unlimited.

Published
2013

45. Political culture and the nature of political participation in Egypt

Author

Amos, J.W., Said, Kamil T., Naval Postgraduate School, National Security Affairs (NSA), Anthony, David J., Amos, J.W., Said, Kamil T., Naval Postgraduate School, National Security Affairs (NSA), and Anthony, David J.

Abstract

This thesis analyzes Egyptian political culture and theimited to any deterioration in the government's identification with Islam, a reduction in the already marginal standard of living or any perceived threat to continued Egyptian independence from any foreign power including the United States or Israel., http://archive.org/details/politicalculture00anth, Captain, United States Army, Approved for public release; distribution is unlimited.

Published
2013

46. Nuclear proliferation : lessons learned from the Iraqi case.

Author

Yost, David S., Said, Kamil T., Naval Postgraduate School, National Security Affairs (NSA), Dixon, Todd A., Yost, David S., Said, Kamil T., Naval Postgraduate School, National Security Affairs (NSA), and Dixon, Todd A.

Abstract

The nuclear weapons inspection regime implemented in Iraq following the United Nations coalition victory in Desert Storm is the most intrusive in history. Important conclusions about the current non-proliferation regime can therefore be determined from a study of Iraq's progress. This thesis examines Iraq's efforts to acquire nuclear weapons. The supply side of the equation is also studied, with a concentration upon the contributions of NATO nations. The strategic culture of Iraq is discussed, in an effort to discover why Iraq sought nuclear weapons. Finally, policy prescriptions are advanced., http://archive.org/details/nuclearprolifera1094523732, First Lieutenant, United States Air Force, Approved for public release; distribution is unlimited.

Published
2012

47. How different kinds of communication and the mass media affect tourism

Author

Said, Kamil T., McGonigal, Richard A., Naval Postgraduate School, Management, Aly, Said A., Goher, Mahmoud Z., Said, Kamil T., McGonigal, Richard A., Naval Postgraduate School, Management, Aly, Said A., and Goher, Mahmoud Z.

Abstract

This thesis attempts to investigate the impact of the mass media and other kinds of communication in terms of making American tourists aware of Egypt as a desirable place to visit and helping them to decide to come to Egypt. The study concentrates on American tourists, since they constitute--and are likely to be--the largest nationality group visiting Egypt. Five hundred and forty-three American tourists from those who visited Egypt during 1981 and the winter of 1982 have been studied for a cross-section of these groups during this time period. A case study and sample survey appeared the suitable methodologies to be used. It is a pilot study in that no previous research has been undertaken dealing with mass communication and the increase of tourism in Egypt. Additional keywords: Diffusion, Theories, Television, Questionnaires, and Tables(Data), http://archive.org/details/howdifferentkind1094519361, Major, Egyptian Armed Forces, Approved for public release; distribution is unlimited.

Published
2012

48. The Arab Gulf Cooperation Council (AGCC) is not just and organization for security, but it is an organization for cooperation in all fields.

Author

Said, Kamil T., Magnus, Ralph H., Al-Quraini, Abdullah J., Said, Kamil T., Magnus, Ralph H., and Al-Quraini, Abdullah J.

Abstract

This thesis examines the main purpose for establishing the AGCC, and proves that it was not created just as a defensive alliance as it is generally perceived in the West. The AGCC was formed for cooperation in all fields among its Member States. To demonstrate this fact, this thesis discusses the historical events that led to the establishment of this organization and analyzes the cooperation of the member states in area of politics, security, economy, as well as the development of human resources. The analysis indicates that the formation of the Shura Council (Consultative National Councils) was the first step in the right direction in building suitable political institutions. They allow the citizens of the AGCC to participate in the decision making process. Also, the thesis examines the external and the internal threats to the region and the AGCC relations with the West. It finds that the AGCC States must enhance the existing (Gulf) Island Shield Force and maintain its alliance with the West. The Study examines the economies of the AGCC States and shows that the AGCC States are still largely oil-based economies. It suggests additional and aggressive economic diversification programs which are needed and essential to base the economies on sustainable resources. The AGCC State must maximize an use oil returns to diversify their economies away from oil. Additionally, the thesis discusses the human resources development and emphasizes the investment in human capital which should be the objective and the priority of the AGCC States. Also, the thesis suggests that the educational system of the AGCC States needs radical reforms to meet the demands of modern economy. Finally, the thesis provides general recommendations to strengthen and move the AGCC forward in the future, http://archive.org/details/thearabgulfcoope109457983

Published
2012

49. The Arab Gulf Cooperation Council (AGCC) is not just and organization for security, but it is an organization for cooperation in all fields.

Author

Said, Kamil T., Magnus, Ralph H., Al-Quraini, Abdullah J., Said, Kamil T., Magnus, Ralph H., and Al-Quraini, Abdullah J.

Abstract

This thesis examines the main purpose for establishing the AGCC, and proves that it was not created just as a defensive alliance as it is generally perceived in the West. The AGCC was formed for cooperation in all fields among its Member States. To demonstrate this fact, this thesis discusses the historical events that led to the establishment of this organization and analyzes the cooperation of the member states in area of politics, security, economy, as well as the development of human resources. The analysis indicates that the formation of the Shura Council (Consultative National Councils) was the first step in the right direction in building suitable political institutions. They allow the citizens of the AGCC to participate in the decision making process. Also, the thesis examines the external and the internal threats to the region and the AGCC relations with the West. It finds that the AGCC States must enhance the existing (Gulf) Island Shield Force and maintain its alliance with the West. The Study examines the economies of the AGCC States and shows that the AGCC States are still largely oil-based economies. It suggests additional and aggressive economic diversification programs which are needed and essential to base the economies on sustainable resources. The AGCC State must maximize an use oil returns to diversify their economies away from oil. Additionally, the thesis discusses the human resources development and emphasizes the investment in human capital which should be the objective and the priority of the AGCC States. Also, the thesis suggests that the educational system of the AGCC States needs radical reforms to meet the demands of modern economy. Finally, the thesis provides general recommendations to strengthen and move the AGCC forward in the future

Published
1997

50. Arab Maghreb Union: achievement and prospects

Author

Said, Kamil T., Evered, Roger, Naval Postgraduate School (U.S.), Messaoudi, Abderrahmen, Said, Kamil T., Evered, Roger, Naval Postgraduate School (U.S.), and Messaoudi, Abderrahmen

Abstract

February 17, 1989, witnessed the signing of the Arab Maghreb Union (AMU) Treaty. This union has been a dream of many generations of U.e peoples of North Africa. It is natural, since history and the shared geographical location have shaped this region into a distinct entity; necessary because only united can the Maghreb region better defend its interests, and increase .. -' ... a. .... •ning power in dealing with the other trading Blocks. The changing global world order, and the emergence of many regional Blocks, motivated the North African countries to work on achieving the integratiun of the region in order to face the internal and external challenges, at the same tim~ contribute to promoting and safeguarding peace and stability around the region. Along with the thoughts on the reality of the North African countries, this project analyses the achievement and the prospects of the Maghreb integration.

Published
1994

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