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46 results on '"Kaliyaperumal Saravanan"'

1. Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

Author

Chukwuebuka Egbuna, Vijaykumar K. Parmar, Jaison Jeevanandam, Shahira M. Ezzat, Kingsley C. Patrick-Iwuanyanwu, Charles Oluwaseun Adetunji, Johra Khan, Eugene N. Onyeike, Chukwuemelie Zedech Uche, Muhammad Akram, Mervat S. Ibrahim, Nihal M. El Mahdy, Chinaza Godswill Awuchi, Kaliyaperumal Saravanan, Habibu Tijjani, Uchenna Estella Odoh, Mohammed Messaoudi, Jonathan C. Ifemeje, Michael C. Olisah, Nebechi Jane Ezeofor, Chukwudi Jude Chikwendu, and Chinwe Gloria Ibeabuchi

Subjects
Toxicology. Poisons, RA1190-1270
Abstract

Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. The extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.

Published
2021
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3. Predictive Control Techniques for Induction Motor Drive for Industrial Applications

Author

Penthala, Thanuja, Kaliyaperumal, Saravanan, Muddineni, Vishnu Prasad, Bonala, Anil Kumar, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Kumar, Amit, editor, Senatore, Sabrina, editor, and Gunjan, Vinit Kumar, editor

Published
2023
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8. A QBD WITH THE FRACTIONAL FACTORIAL DESIGN WAS USED TO MATCH THE SIMILARITY BETWEEN RANOLAZINE EXTENDED-RELEASE TABLETS 500 MG AND 1000 MG

Author

SANKARAIAH JONNA, HANIMI REDDY BAPATU, PRAVEEN SUBBAPPA, and KALIYAPERUMAL SARAVANAN

Subjects
Pharmaceutical Science
Abstract

Objective: Formulation and development of Ranolazine extended-release Tablets 500 mg and 1000 mg by using QBD with Fractional factorial design to match the similarity with Branded formulation (RANEXA®). Methods: Ranolazine extended-release tablets were developed by using various polymers, Polyquid PA100 and ETHOCEL TMstandard 7 premium and Hypromellose with a wet granulation process. QBD (Quality by Design) approach was used to identify the formulation and process variables that may affect the CQAs (critical quality attributes). Excipient compatibility studies were conducted to identify the interaction between API (active pharmaceutical ingredient) and selected excipients. Additionally, using a two-level, fractional factorial (22+3) design, the DOE (design of experiments) was employed to confirm the impacts of key process factors (fluid uptake and kneading time) on the formulation's ability to match the dissolution (f2) compared to RLD (reference listed drug) and establish a stable formulation. Results: Initial risk assessment was carried out to identify the various attributes such as API flow properties, solubility, PSD, Hygroscopicity, formulation, and process variables to impact the quality of the drug product. Flow properties of API indicate poor flow. Drug and excipients compatible study results indicate that excipients used in the compatibility study are considered compatible with the active ingredient. As per the saturation solubility studies and sink conditions, dissolution media was selected. Significant differences were found among the drug release profile by examining the various levels of polymers and binders. Using a two-level, fractional factorial (22+3) design, optimum process parameters were identified with selected formulation to match the dissolution (f2) similarity with the reference listed drug (RLD); finally, XRD (X-ray diffraction) studies confirm that the crystalline polymorphic forms (Form 1) peaks in optimum formulation (F07) comparable to the reference listed drug. Conclusion: Optimized formulation and process were established with QbD (quality by design) that provides the consistent drug release to match the f2 similarities with the extended-release tablets of RANEXA®(Ranolazine) 500 mg and 1000 mg.

Published
2023
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9. Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review

Author

Chukwuebuka Egbuna, Kingsley C. Patrick‐Iwuanyanwu, Eugene N. Onyeike, Johra Khan, Santwana Palai, Sandip B. Patel, Vijaykumar K. Parmar, Garima Kushwaha, Omkar Singh, Jaison Jeevanandam, Suresh Kumarasamy, Chukwuemelie Zedech Uche, Mathiyazhagan Narayanan, Mithun Rudrapal, Uchenna Odoh, Ikenna Chikeokwu, Mihnea‐Alexandru Găman, Kaliyaperumal Saravanan, Jonathan C. Ifemeje, Shahira M. Ezzat, Michael C. Olisah, Chukwudi Jude Chikwendu, Kamoru A. Adedokun, Sikiru O. Imodoye, Ibrahim O. Bello, Hannington Twinomuhwezi, and Chinaza Godswill Awuchi

Subjects
Food Science
Published
2023
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10. Toxic Plants and Phytochemicals

Author

Egbuna, Chukwuebuka, primary, Alan Thomas, S., additional, Kingsley Nwosu, Onyeka, additional, Vincent Oriyomi, Olumayowa, additional, Kryeziu, Toskë L., additional, Kaliyaperumal, Saravanan, additional, and Ifemeje, Jonathan C., additional

Published
2018
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23. Association of Agriculture Occupational Exposure With Diabetes and Cardiovascular Risk Factors in South Indian Villages: REDSI Study

Author

Velmurugan, Ganesan, primary, Mohanraj, Sundaresan, additional, Christy Yacob, Jenifer, additional, Keppanan, Sundaravadivu, additional, Rekha, Balakrishnan, additional, Krishnasamy, Anbalagan, additional, Shanmugarajan, Suresh, additional, Boopathi, Seenivasan, additional, Ayyapparaja, Anitha, additional, Ayyapparaja, Prabhu Chandhran, additional, RS, Tamilselvan, additional, Gopalakrishnan, Manigandan, additional, Veerappan, Jayaramanathan, additional, Dharmaraj, Vithya, additional, Vaithilingam, Subramaniyan, additional, Purushothaman, Priyadharshini, additional, Chelladurai, Sumathi, additional, Pandiyan, Jeevan, additional, Selvarajan, Vijaya Samoondeeswari, additional, Annathurai, Kalidoss, additional, Vengatachalam, Sukumaran, additional, Arivuruvone, Gorky, additional, Kaliyaperumal, Saravanan, additional, G, Velsamy, additional, S, Kannan, additional, Ramasamy, Subbiah, additional, and Swaminathan, Krishnan, additional

Published
2021
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31. List of contributors

Author

Akram, Muhammad, Ancy, V. Benedic, Anyanwu, Gabriel O., Anywar, Godwin, Aslam, Maria, Awojide, Simon, Balakrishnan, Umarani, Bermano, Giovanna, Devaraj, Ezhilarasan, Daniyal, Muhammad, Danquah, Michael K., Dwivedi, Astha, Ebhohimen, Israel Ehizuelen, Edemhanria, Lawrence, Egbuna, Chukwuebuka, El Bishbishy, Mahitab H., Ezzat, Shahira M., Frederick, Ujah O., Găman, Amelia Maria, Găman, Mihnea-Alexandru, Gupta, Ashutosh, Gupta, Vishal Kumar, Gupta, Ena, Haider, S. Zafar, Ifemeje, Jonathan C., Jaiswara, Pradip Kumar, Jeevanandam, Jaison, Joshi, Karnika, Kaliyaperumal, Saravanan, Keskin, Merve, Kolb, Andreas F., Kumar, J.R., Kumar, Sandeep, Kumar, Shashank, Kumar, Ajay, Kumari, Priyanka, Kurhekar, Jaya Vikas, Kushwaha, Prem Prakash, Lohani, Hema, Mishra, Pragya, Mittal, Poonam C., Mtewa, Andrew G., Namukobe, Jane, Mishra, Neha, Nwosu, Onyeka K., Onyijen, Ojei Harrison, Otero, Maria Catherine B., Palanivel, Premalatha, Pandey, Abhay K., Pathak, Manisha, Periyasamy, Karuppannan, Pothabathula, Seshu Vardhan, Prajapati, Sunita Kumari, Premanand, A., Priyanka Singh, Rajkumari, B. Reena, Rawat, Shiv Govind, Riaz, Muhammad, Salama, Maha M., Salem, Mohamed A., Samson, Hough A., Sharma, Shrikant, Shuaib, Mohd, Singh, Sharmistha, Singh, Atul Kumar, Sonker, Pratishtha, Srivastav, Vijay Kumar, Tiwari, Meena, Tupas, Genevieve D., Kavitha Raj, V., Vardhan, Pothabathula Seshu, Walag, Angelo Mark P., and Zainab, Rida

Published
2020
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33. ANTIMICROBIAL ACTIVITY OF RHIZOME EXTRACTS OF CURCUMA CAESIA, CURCUMA AMADA AND CURCUMA ANGUSTIFOLIA.

Author

Yadav, Mamta and Kaliyaperumal, Saravanan

Subjects
*ANTI-infective agents, *CURCUMA, *CIPROFLOXACIN
Abstract

The present investigation was conducted to examine antimicrobial activity of rhizome extracts of Curcuma caesia, Curcuma amada and Curcuma angustifolia. The antibacterial activity of the methanol extract of Curcuma caesia, Curcuma amada and choloroform extract of Curcuma angustifolia was tested against Escherichia coli and Bacillus subtilis bacterial strains. Ofloxacin and ciprofloxacin were taken as a standard reference for antibacterial activities. The methanol extracts of Curcuma caesia showed the highest antibacterial activity than methanol extract of Curcuma amada and chloroform extract of Curcuma angustifolia. Dose-dependent inhibition was observed in all the studies. [ABSTRACT FROM AUTHOR]

Published
2021

35. CD8-Predominant T Cell Meningitis Accompanies Gvhd in Primates and Is Prevented with Immunoprophylaxis

Author

Kaliyaperumal, Saravanan, Sharma, Prachi, Watkins, Benjamin K., Furlan, Scott N., Ramakrishnan, Swetha, Giver, Cynthia, Garcia, Anapatricia, Courtney, Cynthia, Hamby, Kelly, Garrett, Aneesah, Deane, Taylor, Strobert, Elizabeth, Jenkins, Joe, Elder, Eric, Eishiavielli, Natia, Crenshaw, Timothy, Blazar, Bruce R., Waller, Edmund K., Westmoreland, Susan, and Kean, Leslie S.

Published
2014
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37. Evaluation of secondary poisoning of difethialone, a new second-generation anticoagulant rodenticide to barn owl, Tyto alba Hartert under captivity

Author

kaliyaperumal Saravanan and Kanakasabai, R.

Subjects
Muridae, Animals, Anticoagulants, Rodenticides, Female, 4-Hydroxycoumarins, Strigiformes
Abstract

Secondary toxcity of difethialone to Barn owl (Tyto alba) has been investigated. Difethialone was fed to owls for successive periods of 1 (phase 1), 3 (phase 2) and 6 (phase 3) days via-rodenticide dosed rats. The owls survived after the treament of rodenticide on phase 1 and phase 2 experiments but they died during phase 3 experiment. The results suggest that the difethialone could cause more secondary toxicity to owls.

Published
2004

42. Toxicity of Nerium indicum Miller seed extract on bandicoot rat, Bandicota bengalensis Gray

Author

kaliyaperumal Saravanan, Senthilkumar S, Elayaraja M, and Suresh B

Subjects
Muridae, Behavior, Animal, Plant Extracts, Seeds, Animals, Rodenticides, Nerium, Pest Control, Biological
Abstract

Crude extract (12.5 ml/kg) of N. indicum seed gave 100% mortality of B. bengalensis. Humanness assessment study revealed that this plant orgin chemical caused low pain and sufferings to the target pests.

44. Field evaluation of difethialone, a new second generation anticoagulant rodenticide in the rice fields

Author

kaliyaperumal Saravanan, Kanakasabai, R., and Thiyagesan, K.

Subjects
Crops, Agricultural, Anticoagulants, Rodenticides, Oryza, 4-Hydroxycoumarins
Abstract

A new second generation anticoagulant rodenticide, difethialone (0.0025%), was evaluated in the rice fields at three different cropping stages, viz. Milky, Panicle formation and Panicle maturation, during Kuruvai and Thaladi seasons. The difethailone (0.0025%) yielded satisfactory control success suggesting a great potential as a rodenticide especially in the early stages of rice.

45. hMSH6 Protein Phosphorylation: DNA Mismatch Repair or DNA Damage Signaling?

Author

Kaliyaperumal, Saravanan

Subjects
Biology, DNA Repair, Protein Phosphorylation, mismatch repair, alkylation damage response, MSH6 Protein Phosphorylation, MNNG damage signaling
Abstract

The Mismatch repair (MMR) system maintains genomic stability byrepairing DNA mismatches and insertion-deletion loops (IDLs) resulting from replicationand recombination errors. Defective MMR can lead to hereditary non-polyposiscolorectal cancer (HNPCC) and sporadic forms of cancer. In human cells, mismatches arerecognized and bound by a heterodimer, hMSH2-hMSH6 (hMutSα). A secondheterodimer, hMLH1-hPMS2 (hMutLα) interacts with hMutSα and is thought to act as amediator for downstream repair proteins. An additional role for MMR pathway is totrigger cell cycle arrest and apoptosis upon recognition and binding of MutSα to specificDNA lesions such as O6 methyldeoxyguanine (O6-meG). Limited information is availableregarding the cellular regulation of these proteins. Within this report, we demonstrate thathMSH6, but not hMSH2, undergoes phosphorylation within cells. Phosphorylation ofhMSH6 is enhanced by addition of TPA, a PKC activator. Alternatively, UCN-01, aPKC and Chk1/Chk2 kinase inhibitor, decreases hMSH6 phosphorylation and mismatchbindingactivity of hMutSα to both G:T and O6 -meG:T-containing DNA. We show thatphosphorylated hMSH6 is higher in concentration in the presence of a G:T mismatch, ascompared to an O6 -meG:T lesion.However, the total quantity of hMutSα bound to O6 -meG:T–containing DNA is higherthan that bound to G:T-containing DNA. We also demonstrate that MMR proficient cellstreated with a low concentration of N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)undergo cell cycle arrest after one complete cell cycle. When these cells are co-treatedwith UCN-01 the G2/M arrest is abrogated and the cells rapidly die. This abrogation ofarrest is not due to Chk1 kinase inhibition but rather through Cdc2 activation byincreased Tyr15 dephosphorylation. Taken together, we hypothesize that bothphosphorylation and total concentration of hMutSα are involved in the signaling of eitherDNA mismatch repair or damage recognition activities. We also hypothesize thatdecreased hMSH6 phosphorylation may be an integral part of UCN-01 mediatedinhibition of G2/M cell cycle arrest in MNNG damage signaling response. A final vitaloutcome of these studies is a new gain of insight into the level of difficulty in expressionof full-length hMSH6 cDNA in mammalian cells.

Published
2009

46. Animal Models of Peripheral Pain: Biology Review and Application for Drug Discovery.

Author

Kaliyaperumal S, Wilson K, Aeffner F, and Dean C Jr

Subjects
Animals, Biology, Disease Models, Animal, Pain physiopathology, Pain Measurement, Drug Discovery, Peripheral Nervous System pathology
Abstract

Pain is a complex constellation of cognitive, unpleasant sensory, and emotional experiences that primarily serves as a survival mechanism. Pain arises in the peripheral nervous system and pain signals synapse with nerve tracts extending into the central nervous system. Several different schemes are used to classify pain, including the underlying mechanism, tissues primarily affected, and time-course. Numerous animal models of pain, which should be employed with appropriate Institutional Animal Care and Use approvals, have been developed to elucidate pathophysiology mechanisms and aid in identification of novel therapeutic targets. The variety of available models underscores the observations that pain phenotypes are driven by several distinct mechanisms. Pain outcome measurement encompasses both reflexive (responses to heat, cold, mechanical and electrical stimuli) and nonreflexive (spontaneous pain responses to stimuli) behaviors. However, the question of translatability to human pain conditions and potential treatment outcomes remains a topic of continued scrutiny. In this review we discuss the different types of pain and their mechanisms and pathways, available rodent pain models with an emphasis on type of pain stimulations and pain outcome measures and discuss the role of pathologists in assessing and validating pain models.

Published
2020
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