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7. Malignant Tumors

Author

Lewis, Blair S., Keuchel, Martin, Wiedbrauck, Felix, Caselitz, Jörg, Kakugawa, Yasuo, Saito, Yutaka, Keuchel, Martin, editor, Hagenmüller, Friedrich, editor, and Tajiri, Hisao, editor

Published
2014
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14. Endoscopic features of colorectal lymphoma according to histological type

Author

Yachida, Tatsuo, primary, Matsuda, Takahisa, additional, Sakamoto, Taku, additional, Nakajima, Takeshi, additional, Kakugawa, Yasuo, additional, Maeshima, Akiko Miyagi, additional, Taniguchi, Hirokazu, additional, Kushima, Ryoji, additional, Tobinai, Kensei, additional, Kobara, Hideki, additional, Masugata, Hisashi, additional, Masaki, Tsutomu, additional, and Saito, Yutaka, additional

Published
2022
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16. Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan

Author

Iwasaki, Motoki, primary, Kanehara, Rieko, additional, Yamaji, Taiki, additional, Katagiri, Ryoko, additional, Mutoh, Michihiro, additional, Tsunematsu, Yuta, additional, Sato, Michio, additional, Watanabe, Kenji, additional, Hosomi, Koji, additional, Kakugawa, Yasuo, additional, Ikematsu, Hiroaki, additional, Hotta, Kinichi, additional, Kunisawa, Jun, additional, Wakabayashi, Keiji, additional, and Matsuda, Takahisa, additional

Published
2021
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19. Diagnosis and evaluation of intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation following reduced-intensity and myeloablative conditioning regimens

Author

Yamasaki, Satoshi, Miyagi-Maeshima, Akiko, Kakugawa, Yasuo, Matsuno, Yoshihiro, Ohara-Waki, Fusako, Fuji, Shigeo, Morita-Hoshi, Yuriko, Mori, Masakazu, Kim, Sung-Won, Mori, Shin-ichiro, Fukuda, Takahiro, Tanosaki, Ryuji, Shimoda, Tadakazu, Tobinai, Kensei, Saito, Daizo, Takaue, Yoichi, Teshima, Takanori, and Heike, Yuji

Published
2013
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25. Risk Stratification Score Improves Sensitivity for Advanced Colorectal Neoplasia in Colorectal Cancer Screening: The Oshima Study Workgroup

Author

Sekiguchi, Masau, primary, Kakugawa, Yasuo, additional, Ikematsu, Hiroaki, additional, Hotta, Kinichi, additional, Konda, Kenichi, additional, Tanaka, Yusaku, additional, Takamaru, Hiroyuki, additional, Yamada, Masayoshi, additional, Sakamoto, Taku, additional, Saito, Yutaka, additional, Imai, Kenichiro, additional, Ito, Sayo, additional, Koga, Yoshikatsu, additional, Iwasaki, Motoki, additional, Murakami, Yoshitaka, additional, and Matsuda, Takahisa, additional

Published
2021
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28. Prevalence of serrated lesions, risk factors, and their association with synchronous advanced colorectal neoplasia in asymptomatic screened individuals

Author

Sekiguchi, Masau, primary, Kakugawa, Yasuo, additional, Matsumoto, Minori, additional, Nakamura, Keiko, additional, Mizuguchi, Yasuhiko, additional, Takamaru, Hiroyuki, additional, Yamada, Masayoshi, additional, Sakamoto, Taku, additional, Saito, Yutaka, additional, and Matsuda, Takahisa, additional

Published
2020
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29. Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan.

Author

Iwasaki, Motoki, Kanehara, Rieko, Yamaji, Taiki, Katagiri, Ryoko, Mutoh, Michihiro, Tsunematsu, Yuta, Sato, Michio, Watanabe, Kenji, Hosomi, Koji, Kakugawa, Yasuo, Ikematsu, Hiroaki, Hotta, Kinichi, Kunisawa, Jun, Wakabayashi, Keiji, and Matsuda, Takahisa

Abstract

Escherichia coli containing polyketide synthase in the gut microbiota (pks+E coli) produce a polyketide‐peptide genotoxin, colibactin, and are suspected to play a role in the development of colorectal neoplasia. To clarify the role of pks+E coli in the early stage of tumorigenesis, we investigated whether the pks status of E coli was associated with the prevalence of colorectal neoplasia. This cross‐sectional analysis of data from a prospective cohort in Izu Oshima, Japan included asymptomatic residents aged 40‐79 years who underwent screening colonoscopy and provided a stool sample. We identified 543 participants with colorectal neoplasia (22 colorectal cancer and 521 adenoma) as cases and 425 participants with normal colon as controls. The pks status of E coli was assayed using stool DNA and specific primers that detected pks+E coli. The proportion of pks+E coli was 32.6% among cases and 30.8% among controls. Compared with those with pks−E coli, the odds ratio (OR) (95% confidence interval) for participants with pks+E coli was 1.04 (0.77‐1.41) after adjusting for potential confounders. No statistically significant associations were observed regardless of tumor site or number of colorectal adenoma lesions. However, stratified analyses revealed increased ORs among participants who consumed cereals over the median intake or vegetables under the median intake. Overall, we found no statistically significant association between pks+E coli and the prevalence of colorectal adenoma lesions among this Japanese cohort. However, positive associations were suggested under certain intake levels of cereals or vegetables. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality

Author

Inoki, Kazuya, primary, Kakugawa, Yasuo, additional, Takamaru, Hiroyuki, additional, Sekiguchi, Masau, additional, Matsumoto, Minori, additional, Matsuda, Takahisa, additional, Ito, Ayumu, additional, Tanaka, Takashi, additional, Inamoto, Yoshihiro, additional, Fuji, Shigeo, additional, Kurosawa, Saiko, additional, Kim, Sung-Won, additional, Fukuda, Takahiro, additional, Ohe, Yuichiro, additional, and Saito, Yutaka, additional

Published
2019
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35. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality.

Author

Inoki, Kazuya, Kakugawa, Yasuo, Takamaru, Hiroyuki, Sekiguchi, Masau, Matsumoto, Minori, Matsuda, Takahisa, Ito, Ayumu, Tanaka, Takashi, Inamoto, Yoshihiro, Fuji, Shigeo, Kurosawa, Saiko, Kim, Sung-Won, Fukuda, Takahiro, Ohe, Yuichiro, and Saito, Yutaka

Subjects
*HEMATOPOIETIC stem cell transplantation, *CAPSULE endoscopy, *CYTOMEGALOVIRUS diseases, *GRAFT versus host disease
Abstract

Background and Objectives: Allogenic hematopoietic stem cell transplantation (allo-SCT) is a curative therapy for hematological malignancies, but transplant-related mortality (TRM) remains a concern. This study aimed to determine the efficacy of capsule endoscopy (CE) by evaluating the correlation between inflammatory findings on CE and TRM. Methods: The data of patients after allo-SCT were retrospectively collected. The association between findings on CE and TRM at 100 days from the CE was evaluated. Results: Of the 94 patients included in the study, 47 showed inflammatory findings on CE. The findings were diagnosed as graft-versus-host disease (GVHD; n = 17), cytomegalovirus (CMV) infection (n = 14), and GVHD with CMV infection (n = 16). Of the 47 patients, 13 (28%) had TRM. Endoscopic diagnoses of these TRM cases were GVHD (n = 4), CMV infection (n = 0), and GVHD with CMV infection (n = 9). In contrast, in the remaining 47 patients who showed no inflammatory findings on CE, 2 patients (4%) had TRM. The proportion of TRM was higher in patients with inflammatory findings than in those without it (28 vs. 4%, p < 0.01). Conclusions: CE may predict TRM in patients who developed gastrointestinal symptoms after allo-SCT. [ABSTRACT FROM AUTHOR]

Published
2020
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36. Feasibility of observational screening colonoscopy followed by deferred polypectomy.

Author

Sekiguchi, Masau, Kakugawa, Yasuo, Nakamura, Keiko, Matsumoto, Minori, Takamaru, Hiroyuki, Yamada, Masayoshi, Sakamoto, Taku, Saito, Yutaka, and Matsuda, Takahisa

Subjects
*COLONOSCOPY, *ADENOMATOUS polyps, *COLON polyps, *COLON cancer, *EARLY detection of cancer, *POLYPECTOMY
Abstract

Background and Aim: With the increasing necessity of colorectal cancer screening, observational screening colonoscopy during which only endoscopic observation and diagnosis is performed is worth consideration. However, whether detected lesions can be correctly identified at secondary colonoscopy performed for polypectomy is unclear. Further, whether new neoplastic lesions can be detected at secondary colonoscopy has not been fully examined. This study was performed to investigate the detectability of adenomatous polyps and advanced colorectal neoplasia (ACN) at secondary colonoscopy. Methods: Data were analyzed from individuals who underwent initial observational screening colonoscopy followed by secondary colonoscopy for polypectomy. The proportion of correct detection at secondary colonoscopy of the lesions detected at initial colonoscopy was assessed. The number and characteristics of lesions that were newly detected at secondary colonoscopy were also evaluated. Results: Data of 587 individuals were assessed. Among the 1 331 lesions detected at the initial colonoscopy, 1 151 (86.5%) were properly detected at the secondary colonoscopy. The proportions of correct detection at the secondary colonoscopy for ACN, non‐advanced adenomas sized 5 to 9 mm, and non‐advanced adenomas sized 1 to 4 mm were 100%, 95.4%, and 70.3%, respectively. In total, 175 adenomatous polyps and ACNs were newly detected at secondary colonoscopy in 112 individuals (19.1% of all individuals). Most of the lesions (165 lesions, 94.3%) were non‐advanced adenomas, while advanced adenomas (5.7%) were also found. Conclusion: Screening by observational colonoscopy followed by deferred polypectomy is a feasible option in terms of lesion detectability, particularly when lesions sized ≥ 5 mm are the treatment target. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Mo1123 Capsule Endoscopy After Hematopoietic Stem Cell Transplantation Can Predict Transplantation-Related Mortality

Author

Inoki, Kazuya, primary, Kakugawa, Yasuo, additional, Takamaru, Hiroyuki, additional, Sekiguchi, Masau, additional, Matsumoto, Minori, additional, Matsuda, Takahisa, additional, Tanaka, Takashi, additional, Inamoto, Yoshihiro, additional, Fuji, Shigeo, additional, Kurosawa, Saiko, additional, Kim, Sung-Won, additional, Fukuda, Takahiro, additional, and Saito, Yutaka, additional

Published
2017
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40. Regional colorectal cancer screening program using colonoscopy on an island: a prospective Nii-jima study

Author

Hotta, Kinichi, primary, Matsuda, Takahisa, additional, Kakugawa, Yasuo, additional, Ikematsu, Hiroaki, additional, Kobayashi, Nozomu, additional, Kushima, Ryoji, additional, Hozawa, Atsushi, additional, Nakajima, Takeshi, additional, Sakamoto, Taku, additional, Mori, Mika, additional, Fujii, Takahiro, additional, and Saito, Yutaka, additional

Published
2016
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41. Dual camera colon capsule endoscopy increases detection of colorectal lesions

Author

Takamaru, Hiroyuki, primary, Yamada, Masayoshi, additional, Sakamoto, Taku, additional, Nakajima, Takeshi, additional, Saito, Yutaka, additional, Kakugawa, Yasuo, additional, Matsumoto, Minori, additional, Matsuda, Takahisa, additional, Ide, Daisuke, additional, Saito, Shoichi, additional, Gulati, Shraddha, additional, and Tajiri, Hisao, additional

Published
2016
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44. Optimal use of colonoscopy and fecal immunochemical test for population-based colorectal cancer screening: a cost-effectiveness analysis using Japanese data

Author

Sekiguchi, Masau, primary, Igarashi, Ataru, additional, Matsuda, Takahisa, additional, Matsumoto, Minori, additional, Sakamoto, Taku, additional, Nakajima, Takeshi, additional, Kakugawa, Yasuo, additional, Yamamoto, Seiichiro, additional, Saito, Hiroshi, additional, and Saito, Yutaka, additional

Published
2015
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46. Evaluation of the clinical efficacy of colon capsule endoscopy in the detection of lesions of the colon: prospective, multicenter, open study

Author

Saito, Yutaka, primary, Saito, Shoichi, additional, Oka, Shiro, additional, Kakugawa, Yasuo, additional, Matsumoto, Minori, additional, Aihara, Hiroyuki, additional, Watari, Ikue, additional, Aoyama, Taiki, additional, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Watanabe, Kenji, additional, Ohmiya, Naoki, additional, Higuchi, Kazuhide, additional, Goto, Hidemi, additional, Arakawa, Tetsuo, additional, Tanaka, Shinji, additional, and Tajiri, Hisao, additional

Published
2015
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50. Endocuff®-assisted colonoscopy increases polyp detection rate: a simulated randomized study involving an anatomic colorectal model and 32 international endoscopists

Author

Pioche, Mathieu, primary, Matsumoto, Minori, additional, Takamaru, Hiroyuki, additional, Sakamoto, Taku, additional, Nakajima, Takeshi, additional, Matsuda, Takahisa, additional, Abe, Seiichiro, additional, Kakugawa, Yasuo, additional, Otake, Yosuke, additional, and Saito, Yutaka, additional

Published
2015
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