Search

Your search keyword '"Kagalwalla, Amir F."' showing total 197 results
Start Over Author "Kagalwalla, Amir F."
197 results on '"Kagalwalla, Amir F."'

1. Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis

Author

Aceves, Seema S., Abonia, Pablo, Atkins, Dan, Bonis, Peter A., Chehade, Mirna, Falk, Gary W., Furuta, Glenn T., Gupta, Sandeep K., Kagalwalla, Amir F., Kodroff, Ellyn, Kyle, Scholeigh, Leung, John, Menard-Katcher, Paul, Mir, Sabina, Mukkada, Vincent A., Pesek, Robert, Rothenberg, Marc E., Spergel, Jonathan M., Strobel, Mary Jo, Wechsler, Joshua B., Chang, Joy W., Kliewer, Kara, Haller, Emily, Lynett, Amanda, Doerfler, Bethany, Katzka, David A., Peterson, Kathryn A., Dellon, Evan S., and Gonsalves, Nirmala

Published
2023
Full Text
View/download PDF

2. Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults With Eosinophilic Esophagitis

Author

Schoepfer, Alain M, Hirano, Ikuo, Coslovsky, Michael, Roumet, Marie C, Zwahlen, Marcel, Kuehni, Claudia E, Hafner, David, Alexander, Jeffrey A, Dellon, Evan S, Gonsalves, Nirmala, Leung, John, Bussmann, Christian, Collins, Margaret H, Newbury, Robert O, Smyrk, Thomas C, Woosley, John T, Yang, Guang-Yu, Romero, Yvonne, Katzka, David A, Furuta, Glenn T, Gupta, Sandeep K, Aceves, Seema S, Chehade, Mirna, Spergel, Jonathan M, Falk, Gary W, Meltzer, Brian A, Comer, Gail M, Straumann, Alex, Safroneeva, Ekaterina, Group, International EEsAI Study, Achem, Sami R, Arora, Amindra S, Alpan, Oral, Armstrong, David, Attwood, Stephen E, Butterfield, Joseph H, Crowell, Michael D, DeVault, Kenneth R, Drouin, Eric, Enav, Benjamin, Enders, Felicity T, Fleischer, David E, Foxx-Orenstein, Amy, Francis, Dawn L, Guyatt, Gordon H, Harris, Lucinda A, Kagalwalla, Amir F, Kita, Hirohito, Krishna, Murli, Lee, James J, Lewis, John C, Lim, Kaiser, Locke, G Richard, Murray, Joseph A, Nguyen, Cuong C, Orbelo, Diana M, Pasha, Shabana F, Ramirez, Francisco C, Sheikh, Javed, Umar, Sarah B, Weiler, Catherine R, Wo, John M, Wu, Tsung-Teh, and Yost, Kathleen J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Clinical Trials and Supportive Activities, Prevention, Adolescent, Adult, Aged, Anti-Inflammatory Agents, Dose-Response Relationship, Drug, Eosinophilic Esophagitis, Esophagoscopy, Esophagus, Female, Fluticasone, Humans, Male, Middle Aged, Prognosis, Severity of Illness Index, Young Adult, Index, Variability in Endoscopic Assessment, Instrument, International EEsAI Study Group, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsEosinophilic esophagitis (EoE) is assessed endoscopically (endoscopic activity), based on grades of edema, rings, exudates, furrows, and strictures (EREFS). We examined variations in endoscopic assessments of severity, developed and validated 3 EREFS-based scoring systems, and assessed responsiveness of these systems using data from a randomized placebo-controlled trial of patients with EoE.MethodsFor the development set, 5 gastroenterologists reviewed EREFS findings from 266 adults with EoE and provided endoscopist global assessment scores (EndoGA, scale of 0 to 10); variation (ΔEndoGA) was assessed using linear regression. We evaluated simple scores (features given arbitrary values from 0 to 3) and developed 2 scoring systems (adjusted score range, 0-100). We then fitted our linear regression model with mean EndoGA to data from 146 adults recruited in centers in Switzerland and the United States between April 2011 and December 2012. For the validation set, we collected data from 120 separate adults (recruited in centers in Switzerland and the United States between May 2013 and July 2014), assessing regression coefficient-based scores using Bland-Altman method. We assessed the responsiveness of our scoring systems using data from a randomized trial of patients with EoE given fluticasone (n=16) or placebo (n=8).ResultsThe distribution of EndoGA values differed among endoscopists (mean ΔEndoGA, 2.6±1.8; range 0-6.6). We developed 2 regression-based scoring systems to assess overall and proximal and distal esophageal findings; variation in endoscopic features accounted for more than 90% of the mean EndoGA variation. In the validation group, differences between mean EndoGA and regression-based scores were small (ranging from -4.70 to 2.03), indicating good agreement. In analyses of data from the randomized trial, the baseline to end of study change in patients given fluticasone was a reduction of 24.3 in simple score (reduction of 4.6 in patients given placebo, P=.052); a reduction of 23.5 in regression-based overall score (reduction of 6.56 in patients given placebo, P=.12), and a reduction of 23.8 (reduction of 8.44 in patients given placebo, P=.11).ConclusionAssessments of endoscopic activity in patients with EoE vary among endoscopists. In an analysis of data from a randomized controlled trial, we found that newly developed scoring systems are no better than simple scoring system in detecting changes in endoscopic activity. These results support the use of a simple scoring system in evaluation of endoscopic activity in patients with EoE. clinicaltrials.gov no: NCT00939263 and NCT01386112.

Published
2019

5. Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis

Author

Safroneeva, Ekaterina, Straumann, Alex, Coslovsky, Michael, Zwahlen, Marcel, Kuehni, Claudia E, Panczak, Radoslaw, Haas, Nadine A, Alexander, Jeffrey A, Dellon, Evan S, Gonsalves, Nirmala, Hirano, Ikuo, Leung, John, Bussmann, Christian, Collins, Margaret H, Newbury, Robert O, De Petris, Giovanni, Smyrk, Thomas C, Woosley, John T, Yan, Pu, Yang, Guang-Yu, Romero, Yvonne, Katzka, David A, Furuta, Glenn T, Gupta, Sandeep K, Aceves, Seema S, Chehade, Mirna, Spergel, Jonathan M, Schoepfer, Alain M, Group, International Eosinophilic Esophagitis Activity Index Study, Achem, Sami R, Arora, Amindra S, Alpan, Oral, Armstrong, David, Attwood, Stephen E, Butterfield, Joseph H, Crowell, Michael D, DeVault, Kenneth R, Drouin, Eric, Enav, Benjamin, Enders, Felicity T, Fleischer, David E, Foxx-Orenstein, Amy, Francis, Dawn L, Guyatt, Gordon H, Harris, Lucinda A, Kagalwalla, Amir F, Kita, Hirohito, Krishna, Murli, Lee, James J, Lewis, John C, Lim, Kaiser, Locke, G Richard, Murray, Joseph A, Nguyen, Cuong C, Orbelo, Diana M, Pasha, Shabana F, Ramirez, Francisco C, Sheikh, Javed, Umar, Sarah B, Weiler, Catherine R, Wo, John M, Wu, Tsung-Teh, and Yost, Kathleen J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Cancer, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Adolescent, Adult, Aged, Aged, 80 and over, Area Under Curve, Biopsy, Eosinophilic Esophagitis, Eosinophils, Esophagoscopy, Female, Humans, Leukocyte Count, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, ROC Curve, Remission Induction, Reproducibility of Results, Severity of Illness Index, Surveys and Questionnaires, Switzerland, Treatment Outcome, United States, Young Adult, EEsAI, Remission, Endoscopic Grading, Disease Monitoring, International Eosinophilic Esophagitis Activity Index Study Group, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsIt is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission.MethodsBetween April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score

Published
2016

6. Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults With Eosinophilic Esophagitis

Author

Achem, Sami R., Arora, Amindra S., Alpan, Oral, Armstrong, David, Attwood, Stephen E., Butterfield, Joseph H., Crowell, Michael D., DeVault, Kenneth R., Drouin, Eric, Enav, Benjamin, Enders, Felicity T., Fleischer, David E., Foxx-Orenstein, Amy, Francis, Dawn L., Guyatt, Gordon H., Harris, Lucinda A., Kagalwalla, Amir F., Kita, Hirohito, Krishna, Murli, Lee, James J., Lewis, John C., Lim, Kaiser, Locke, G. Richard, III, Murray, Joseph A., Nguyen, Cuong C., Orbelo, Diana M., Pasha, Shabana F., Ramirez, Francisco C., Sheikh, Javed, Umar, Sarah B., Weiler, Catherine R., Wo, John M., Wu, Tsung-Teh, Yost, Kathleen J., Schoepfer, Alain M., Hirano, Ikuo, Coslovsky, Michael, Roumet, Marie C., Zwahlen, Marcel, Kuehni, Claudia E., Hafner, David, Alexander, Jeffrey A., Dellon, Evan S., Gonsalves, Nirmala, Leung, John, Bussmann, Christian, Collins, Margaret H., Newbury, Robert O., Smyrk, Thomas C., Woosley, John T., Yang, Guang-Yu, Romero, Yvonne, Katzka, David A., Furuta, Glenn T., Gupta, Sandeep K., Aceves, Seema S., Chehade, Mirna, Spergel, Jonathan M., Falk, Gary W., Meltzer, Brian A., Comer, Gail M., Straumann, Alex, and Safroneeva, Ekaterina

Published
2019
Full Text
View/download PDF

8. Efficacy of a 4-Food Elimination Diet for Children With Eosinophilic Esophagitis

Author

Kagalwalla, Amir F., Wechsler, Joshua B., Amsden, Katie, Schwartz, Sally, Makhija, Melanie, Olive, Anthony, Davis, Carla M., Manuel-Rubio, Maria, Marcus, Seth, Shaykin, Ronda, Sulkowski, Maureen, Johnson, Kristen, Ross, Jessica N., Riffle, Mary Ellen, Groetch, Marion, Melin-Aldana, Hector, Schady, Deborah, Palac, Hannah, Kim, Kwan-Youn A., Wershil, Barry K., Collins, Margaret H., and Chehade, Mirna

Published
2017
Full Text
View/download PDF

9. Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis

Author

Chang, Joy W., primary, Kliewer, Kara, additional, Haller, Emily, additional, Lynett, Amanda, additional, Doerfler, Bethany, additional, Katzka, David A., additional, Peterson, Kathryn A., additional, Dellon, Evan S., additional, Gonsalves, Nirmala, additional, Aceves, Seema S., additional, Abonia, Pablo, additional, Atkins, Dan, additional, Bonis, Peter A., additional, Chehade, Mirna, additional, Falk, Gary W., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Kagalwalla, Amir F., additional, Kodroff, Ellyn, additional, Kyle, Scholeigh, additional, Leung, John, additional, Menard-Katcher, Paul, additional, Mir, Sabina, additional, Mukkada, Vincent A., additional, Pesek, Robert, additional, Rothenberg, Marc E., additional, Spergel, Jonathan M., additional, Strobel, Mary Jo, additional, and Wechsler, Joshua B., additional

Published
2023
Full Text
View/download PDF

13. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author

Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Safroneeva, Ekaterina, Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, and Safroneeva, Ekaterina

Abstract

Background: End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. Objective: We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. Methods: Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement.

Published
2022

14. Reliability and responsiveness of endoscopic disease activity assessment in eosinophilic esophagitis

Author

Ma, Christopher, primary, Bredenoord, Albert J., additional, Dellon, Evan S., additional, Alexander, Jeffrey A., additional, Biedermann, Luc, additional, Hogan, Malcolm, additional, Guizzetti, Leonardo, additional, Zou, Guangyong, additional, Katzka, David A., additional, Chehade, Mirna, additional, Falk, Gary W., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Kagalwalla, Amir F., additional, Schoepfer, Alain M., additional, Miehlke, Stephan, additional, Moawad, Fouad J., additional, Peterson, Kathryn, additional, Gonsalves, Nirmala P., additional, Straumann, Alex, additional, Wechsler, Joshua B., additional, Rémillard, Julie, additional, Shackelton, Lisa M., additional, Almonte, Hector S., additional, Feagan, Brian G., additional, Jairath, Vipul, additional, and Hirano, Ikuo, additional

Published
2022
Full Text
View/download PDF

15. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author

Ma, Christopher, primary, Schoepfer, Alain M., additional, Dellon, Evan S., additional, Bredenoord, Albert J., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Feagan, Brian G., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Jairath, Vipul, additional, Katzka, David A., additional, Pai, Rish K., additional, Rothenberg, Marc E., additional, Straumann, Alex, additional, Aceves, Seema S., additional, Alexander, Jeffrey A., additional, Arva, Nicoleta C., additional, Atkins, Dan, additional, Biedermann, Luc, additional, Blanchard, Carine, additional, Cianferoni, Antonella, additional, Ciriza de los Rios, Constanza, additional, Clayton, Frederic, additional, Davis, Carla M., additional, de Bortoli, Nicola, additional, Dias, Jorge A., additional, Falk, Gary W., additional, Genta, Robert M., additional, Ghaffari, Gisoo, additional, Gonsalves, Nirmala, additional, Greuter, Thomas, additional, Hopp, Russell, additional, Hsu Blatman, Karen S., additional, Jensen, Elizabeth T., additional, Johnston, Doug, additional, Kagalwalla, Amir F., additional, Larsson, Helen M., additional, Leung, John, additional, Louis, Hubert, additional, Masterson, Joanne C., additional, Menard-Katcher, Calies, additional, Menard-Katcher, Paul A., additional, Moawad, Fouad J., additional, Muir, Amanda B., additional, Mukkada, Vincent A., additional, Penagini, Roberto, additional, Pesek, Robert D., additional, Peterson, Kathryn, additional, Putnam, Philip E., additional, Ravelli, Alberto, additional, Savarino, Edoardo V., additional, Schlag, Christoph, additional, Schreiner, Philipp, additional, Simon, Dagmar, additional, Smyrk, Thomas C., additional, Spergel, Jonathan M., additional, Taft, Tiffany H., additional, Terreehorst, Ingrid, additional, Vanuytsel, Tim, additional, Venter, Carina, additional, Vieira, Mario C., additional, Vieth, Michael, additional, Vlieg-Boerstra, Berber, additional, von Arnim, Ulrike, additional, Walker, Marjorie M., additional, Wechsler, Joshua B., additional, Woodland, Philip, additional, Woosley, John T., additional, Yang, Guang-Yu, additional, Zevit, Noam, additional, and Safroneeva, Ekaterina, additional

Published
2022
Full Text
View/download PDF

17. Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity

Author

Safroneeva, E., Coslovsky, M., Kuehni, C. E., Zwahlen, M., Haas, N. A., Panczak, R., Taft, T. H., Hirano, I., Dellon, E. S., Gonsalves, N., Leung, J., Bussmann, C., Woosley, J. T., Yan, P., Romero, Y., Furuta, G. T., Gupta, S. K., Aceves, S. S., Chehade, M., Straumann, A., Schoepfer, A. M., Achem, Sami R., Arora, Amindra S., Alpan, Oral, Alexander, Jeffrey A., Armstrong, David, Attwood, Stephen E., Butterfield, Joseph H., Crowell, Michael D., De Petris, Giovanni, DeVault, Kenneth R., Drouin, Eric, Enav, Benjamin, Enders, Felicity T., Fleischer, David E., Foxx-Orenstein, Amy, Francis, Dawn L., Guyatt, H., Harris, Lucinda A., Kagalwalla, Amir F., Katzka, David A., Kern, Emily, Kita, Hirohito, Krishna, Murli, Lee, James J., Lewis, John C., Lim, Kaiser, Locke, Richard G., III, Moawad, Fouad J., Murray, oseph A., Nguyen, Cuong C., Newbury, Robert O., Orbelo, Diana M., Pasha, Shabana F., Ramirez, Francisco C., Sheikh, Javed, Smyrk, Thomas C., Spergel, Jonathan M., Umar, Sarah B., Weiler, Catherine R., Wo, John M., Wu, Tsung-Teh, Yang, Guang-Yu, and Yost, Kathleen J.

Published
2015
Full Text
View/download PDF

18. Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus

Author

Ma, Christopher, primary, Schoepfer, Alain M., additional, Safroneeva, Ekaterina, additional, Ma, Christopher, additional, Dellon, Evan S., additional, Bredenoord, Albert J., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Feagan, Brian G., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Jairath, Vipul, additional, Katzka, David A., additional, Pai, Rish K., additional, Rothenberg, Marc E., additional, Straumann, Alex, additional, Aceves, Seema S., additional, Alexander, Jeffrey A., additional, Arva, Nicoleta C., additional, Atkins, Dan, additional, Biedermann, Luc, additional, Blanchard, Carine, additional, Cianferoni, Antonella, additional, Ciriza de los Rios, Constanza, additional, Clayton, Frederic, additional, Davis, Carla M., additional, de Bortoli, Nicola, additional, Dias, Jorge A., additional, Falk, Gary W., additional, Genta, Robert M., additional, Ghaffari, Gisoo, additional, Gonsalves, Nirmala, additional, Greuter, Thomas, additional, Hopp, Russell, additional, Hsu Blatman, Karen S., additional, Jensen, Elizabeth T., additional, Johnston, Doug, additional, Kagalwalla, Amir F., additional, Larsson, Helen M., additional, Leung, John, additional, Louis, Hubert, additional, Masterson, Joanne C., additional, Menard-Katcher, Calies, additional, Menard-Katcher, Paul A., additional, Moawad, Fouad J., additional, Muir, Amanda B., additional, Mukkada, Vincent A., additional, Penagini, Roberto, additional, Pesek, Robert D., additional, Peterson, Kathryn, additional, Putnam, Philip E., additional, Ravelli, Alberto, additional, Savarino, Edoardo V., additional, Schlag, Christoph, additional, Schreiner, Philipp, additional, Simon, Dagmar, additional, Smyrk, Thomas C., additional, Spergel, Jonathan M., additional, Taft, Tiffany H., additional, Terreehorst, Ingrid, additional, Vanuytsel, Tim, additional, Venter, Carina, additional, Vieira, Mario C., additional, Vieth, Michael, additional, Vlieg-Boerstra, Berber, additional, von Arnim, Ulrike, additional, Walker, Marjorie M., additional, Wechsler, Joshua B., additional, Woodland, Philip, additional, Woosley, John T., additional, Yang, Guang-Yu, additional, and Zevit, Noam, additional

Published
2021
Full Text
View/download PDF

19. A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus

Author

Ma, Christopher, primary, Schoepfer, Alain M., additional, Safroneeva, Ekaterina, additional, Ma, Christopher, additional, Dellon, Evan S., additional, Bredenoord, Albert J., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Feagan, Brian G., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Jairath, Vipul, additional, Katzka, David A., additional, Pai, Rish K., additional, Rothenberg, Marc E., additional, Straumann, Alex, additional, Aceves, Seema S., additional, Alexander, Jeffrey A., additional, Arva, Nicoleta C., additional, Atkins, Dan, additional, Biedermann, Luc, additional, Blanchard, Carine, additional, Cianferoni, Antonella, additional, Ciriza de los Rios, Constanza, additional, Clayton, Frederic, additional, Davis, Carla M., additional, de Bortoli, Nicola, additional, Dias, Jorge A., additional, Falk, Gary W., additional, Genta, Robert M., additional, Ghaffari, Gisoo, additional, Gonsalves, Nirmala, additional, Greuter, Thomas, additional, Hopp, Russell, additional, Hsu Blatman, Karen S., additional, Jensen, Elizabeth T., additional, Johnston, Doug, additional, Kagalwalla, Amir F., additional, Larsson, Helen M., additional, Leung, John, additional, Louis, Hubert, additional, Masterson, Joanne C., additional, Menard-Katcher, Calies, additional, Menard-Katcher, Paul A., additional, Moawad, Fouad J., additional, Muir, Amanda B., additional, Mukkada, Vincent A., additional, Penagini, Roberto, additional, Pesek, Robert D., additional, Peterson, Kathryn, additional, Putnam, Philip E., additional, Ravelli, Alberto, additional, Savarino, Edoardo V., additional, Schlag, Christoph, additional, Schreiner, Philipp, additional, Simon, Dagmar, additional, Smyrk, Thomas C., additional, Spergel, Jonathan M., additional, Taft, Tiffany H., additional, Terreehorst, Ingrid, additional, Vanuytsel, Tim, additional, Venter, Carina, additional, Vieira, Mario C., additional, Vieth, Michael, additional, Vlieg-Boerstra, Berber, additional, von Arnim, Ulrike, additional, Walker, Marjorie M., additional, Wechsler, Joshua B., additional, Woodland, Philip, additional, Woosley, John T., additional, Yang, Guang-Yu, additional, and Zevit, Noam, additional

Published
2021
Full Text
View/download PDF

20. A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus

Author

Ma, Christopher, Schoepfer, Alain M., Safroneeva, Ekaterina, Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Ma, Christopher, Schoepfer, Alain M., Safroneeva, Ekaterina, Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, and Zevit, Noam

Abstract

The Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) collaborators are a group of more than 70 gastroenterologists, pathologists, allergists, researchers, dietitians, psychologists, and methodologists who convened in a series of in-person and virtual meetings between 2018 and 2020 with the aim of developing a core outcome set (COS) for use in therapeutic studies of pharmacologic and dietary therapies for the treatment of eosinophilic esophagitis (EoE). Given heterogeneity in reported outcomes and uncertainties regarding the most appropriate end points for use in both randomized controlled trials (RCTs) and observational studies involving EoE patients, the EoE experts launched the COREOS exercise in 2018 to standardize outcome definitions using methods established by the Core Outcome Measures in Effectiveness Trials (COMET) initiative.1,2 The COS was developed using a multiphase approach, which is summarized in Figure 1. In the first phase, systematic reviews of the literature and patient engagement surveys were conducted to identify candidate outcomes that have been previously measured and are important to patients with EoE. Next, this information was used to build a framework of different outcome domains, and working groups for each domain were assembled to review the literature for relevant end points.3–6 The relative importance of these domains was categorized in a Delphi survey as core, important, and research agenda domains, and discussed in a moderated in-person meeting on May 17, 2019 at Digestive Disease Week (San Diego, CA). In phase 3, a comprehensive list of outcome measures within each of the core domains was evaluated by the COREOS collaborators in a 2-round Delphi survey and, finally, outcomes were ratified in a virtual meeting on December 8, 2020. In this meeting summary, we highlight the major points of discussion that occurred during the development of the EoE COS.

Published
2021

21. Noninvasive biomarkers identify eosinophilic esophagitis: A prospective longitudinal study in children

Author

Wechsler, Joshua B., primary, Ackerman, Steven J., additional, Chehade, Mirna, additional, Amsden, Katie, additional, Riffle, Mary E., additional, Wang, Ming‐Yu, additional, Du, Jian, additional, Kleinjan, Matt L., additional, Alumkal, Preeth, additional, Gray, Elizabeth, additional, Kim, Kwang‐Youn A., additional, Wershil, Barry K., additional, and Kagalwalla, Amir F., additional

Published
2021
Full Text
View/download PDF

22. The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis

Author

Furuta, Glenn T, Kagalwalla, Amir F, Lee, James J, Alumkal, Preeth, Maybruck, Brian T, Fillon, Sophie, Masterson, Joanne C, Ochkur, Sergei, Protheroe, Cheryl, Moore, Wendy, Pan, Zhaoxing, Amsden, Katie, Robinson, Zachary, Capocelli, Kelley, Mukkada, Vince, Atkins, Dan, Fleischer, David, Hosford, Lindsay, Kwatia, Mark A, Schroeder, Shauna, Kelly, Caleb, Lovell, Mark, Melin-Aldana, Hector, and Ackerman, Steven J

Published
2013
Full Text
View/download PDF

25. Mast Cell Infiltration Is Associated With Persistent Symptoms and Endoscopic Abnormalities Despite Resolution of Eosinophilia in Pediatric Eosinophilic Esophagitis

Author

Bolton, Scott M., primary, Kagalwalla, Amir F., additional, Arva, Nicoleta C., additional, Wang, Ming-Yu, additional, Amsden, Katie, additional, Melin-Aldana, Hector, additional, Dellon, Evan S., additional, Bryce, Paul J., additional, Wershil, Barry K., additional, and Wechsler, Joshua B., additional

Published
2020
Full Text
View/download PDF

29. One-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis

Author

Ackerman, Steven J., Kagalwalla, Amir F., Hirano, Ikuo, Gonsalves, Nirmala, Katcher, Paul Menard, Gupta, S., Wechsler, Joshua B., Grozdanovic, Milica, Pan, Zhaoxing, Masterson, Joanne C., Du, Jian, Fantus, Robert J., Alumkal, Preeth, Lee, James J., Ochkur, Sergei I., Ahmed, Faria, Capocelli, Kelley E., Melin-Aldana, Hector, Biette, K.A., Dubner, Allison, Amsden, Katie, Keeley, Kaitlin, Sulkowski, Maureen, Zalewski, Angelika, Atkins, Dan, Furuta, Glenn T., Ackerman, Steven J., Kagalwalla, Amir F., Hirano, Ikuo, Gonsalves, Nirmala, Katcher, Paul Menard, Gupta, S., Wechsler, Joshua B., Grozdanovic, Milica, Pan, Zhaoxing, Masterson, Joanne C., Du, Jian, Fantus, Robert J., Alumkal, Preeth, Lee, James J., Ochkur, Sergei I., Ahmed, Faria, Capocelli, Kelley E., Melin-Aldana, Hector, Biette, K.A., Dubner, Allison, Amsden, Katie, Keeley, Kaitlin, Sulkowski, Maureen, Zalewski, Angelika, Atkins, Dan, and Furuta, Glenn T.

Abstract

OBJECTIVES: Eosinophilic esophagitis (EoE), a chronic food allergic disease, lacks sensitive and specific peripheral biomarkers. We hypothesized that levels of EoE-related biomarkers captured using a 1-hour minimally invasive Esophageal String Test (EST) would correlate with mucosal eosinophil counts and tissue concentrations of these same biomarkers. We aimed to determine whether a 1-hour EST accurately distinguishes active from inactive EoE or a normal esophagus. METHODS: In a prospective, multisite study, children and adults (ages 7–55 years) undergoing a clinically indicated esophagogastroduodenoscopy performed an EST with an esophageal dwell time of 1 hour. Subjects were divided into 3 groups: active EoE, inactive EoE, and normal esophageal mucosa. Eosinophil-associated protein levels were compared between EST effluents and esophageal biopsy extracts. Statistical modeling was performed to select biomarkers that best correlated with and predicted eosinophilic inflammation. RESULTS: One hundred thirty-four subjects (74 children, 60 adults) with active EoE (n 5 62), inactive EoE (n 5 37), and patient controls with a normal esophagus (n 5 35) completed the study. EST-captured eosinophil-associated biomarkers correlated significantly with peak eosinophils/high-power field, endoscopic visual scoring, and the same proteins extracted from mucosal biopsies. Statistical modeling, using combined eotaxin-3 and major basic protein-1 concentrations, led to the development of EoE scores that distinguished subjects with active EoE from inactive EoE or normal esophagi. Eightyseven percent of children, 95% of parents, and 92% of adults preferred the EST over endoscopy if it provided similar information. DISCUSSION: The 1-hour EST accurately distinguishes active from inactive EoE in children and adults and may facilitate monitoring of disease activity in a safe and minimally invasive fashion.

Published
2019

31. One-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis

Author

Ackerman, Steven J., primary, Kagalwalla, Amir F., additional, Hirano, Ikuo, additional, Gonsalves, Nirmala, additional, Katcher, Paul Menard, additional, Gupta, Sandeep, additional, Wechsler, Joshua B., additional, Grozdanovic, Milica, additional, Pan, Zhaoxing, additional, Masterson, Joanne C., additional, Du, Jian, additional, Fantus, Robert J., additional, Alumkal, Preeth, additional, Lee, James J., additional, Ochkur, Sergei, additional, Ahmed, Faria, additional, Capocelli, Kelley, additional, Melin-Aldana, Hector, additional, Biette, Kathryn, additional, Dubner, Allison, additional, Amsden, Katie, additional, Keeley, Kaitlin, additional, Sulkowski, Maureen, additional, Zalewski, Angelika, additional, Atkins, Dan, additional, and Furuta, Glenn T., additional

Published
2019
Full Text
View/download PDF

32. 817 – Efficacy of 1-Food and 4-Food Elimination Diets for Pediatric Eosinophilic Esophagitis in a Randomized Multi-Site Study

Author

Kliewer, Kara, primary, Aceves, Seema S., additional, Atkins, Dan, additional, Bonis, Peter A., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Dellon, Evan S., additional, Fei, Lin, additional, Gupta, Sandeep K., additional, Kagalwalla, Amir F., additional, Mir, Sabina, additional, Mukkada, Vincent A., additional, Pesek, Robbie, additional, Spergel, Jonathan, additional, Yang, Guang-Yu, additional, and Rothenberg, Marc E., additional

Published
2019
Full Text
View/download PDF

33. The 1-Hour Esophageal String Test: A Non-Endoscopic Minimally Invasive Test to Accurately Detect Disease Activity in Eosinophilic Esophagitis

Author

Ackerman, Steven J., primary, Kagalwalla, Amir F., additional, Hirano, Ikuo, additional, Gonsalves, Nirmala, additional, Menard-Katcher, Paul, additional, Gupta, Sandeep, additional, Wechsler, Joshua B., additional, Grozdanovic, Milica M., additional, Pan, Zhaoxing, additional, Masterson, Joanne C., additional, Du, Jian, additional, Fantus, Robert J., additional, Ochkur, Sergei I., additional, Ahmed, Faria, additional, Capocelli, Kelley E., additional, Melin-Aldana, Hector, additional, Hammer, Juliet, additional, Dubner, Allison, additional, Amsden, Katie, additional, Keeley, Kaitlin, additional, Sulkowski, Maureen, additional, Zalewski, Angelika, additional, Atkins, Fred (Dan), additional, and Furuta, Glenn T., additional

Published
2019
Full Text
View/download PDF

36. Substantial Variability in Biopsy Practice Patterns Among Gastroenterologists for Suspected Eosinophilic Gastrointestinal Disorders

Author

Dellon, Evan S., Collins, Margaret H., Bonis, Peter A., Leung, John, Capocelli, Kelley E., Dohil, Ranjan, Falk, Gary W., Furuta, Glenn T., Menard-Katcher, Calies, Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish S., Kagalwalla, Amir F., Wershil, Barry K., Liacouras, Chris A., Muir, Amanda B., Mukkada, Vincent A., Putnam, Philip E., Schoepfer, Alain M., Straumann, Alex, Wo, John M., Yang, Guang-Yu, Rothenberg, Marc E., and Gonsalves, Nirmala

Published
2016
Full Text
View/download PDF

37. Tutorial: Nutrition Therapy in Eosinophilic Esophagitis-Outcomes and Deficiencies.

Author

Bashaw, Hillary, Schwartz, Sally, Kagalwalla, Amir F., and Wechsler, Joshua B.

Subjects
EOSINOPHILIC esophagitis, DIET therapy, NUTRITION, DIET, DIETITIANS, EOSINOPHILS, FOOD
Abstract

Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease that presents with symptoms of esophageal dysfunction, which vary by age. Diagnosis is made by upper endoscopy with esophageal biopsies to identify dense eosinophilic inflammation with at least 15 eosinophils per high-power field. Untreated, EoE can progress from inflammatory to esophageal remodeling with fibrosis and stricture formation. Food antigens are the primary trigger of inflammation in EoE. The most common food antigen triggers are dairy, wheat, egg, and soy. EoE can be managed with steroids or dietary elimination of food triggers. Elimination diets differ by the number of foods removed with specific nutrition implications for each diet. In addition, patients receiving swallowed steroids may have feeding dysfunction and need support for growth and nutrition intake. A multidisciplinary approach to care, including a dietitian, is integral to EoE management. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

38. Sa1161 - Mast Cell Density is Increased in Children with Eosinophilic Esophagitis Who have Persistent Symptoms, Endoscopic Findings, or Epithelial Abnormalities Despite Low Eosinophil Counts after Treatment

Author

Bolton, Scott, primary, Kagalwalla, Amir F., additional, Arva, Nicoleta, additional, Wang, Ming, additional, Amsden, Katie, additional, Melin-Aldana, Hector, additional, Dellon, Evan S., additional, Wershil, Barry K., additional, and Wechsler, Joshua B., additional

Published
2018
Full Text
View/download PDF

42. Diagnostic Utility of Allergy Testing in Children Undergoing Four-Food Elimination Diet for Eosinophilic Esophagitis

Author

Kagalwalla, Amir F., primary, Wechsler, Joshua B., additional, Schwartz, Sally, additional, Makhija, Melanie M., additional, Olive, Anthony P., additional, Davis, Carla M., additional, Manuel-Rubio, Maria, additional, Amsden, Katie, additional, Johnson, Kristin, additional, Ross, Jessica, additional, Sulkowski, Maureen, additional, Melin-Aldana, Hector, additional, Schady, Deborah, additional, Wershil, Barry K., additional, Collins, Margaret H., additional, and Chehade, Mirna, additional

Published
2017
Full Text
View/download PDF

46. Pulmonary hemorrhage in association with autoimmune chronic active hepatitis

Author

Kagalwalla, Amir F., Taleb, Abdul Rahman M. Abu, Kagalwalla, Yasmeen A., Ali, Mir Mumtaz, and Yaish, Hassan

Subjects
Hemorrhage -- Causes of -- Complications and side effects -- Diagnosis, Pulmonary manifestations of general diseases -- Diagnosis -- Complications and side effects, Chronic active hepatitis -- Complications and side effects -- Diagnosis, Health, Diagnosis, Complications and side effects, Causes of
Abstract

Extrahepatic manifestations have been reported in a majority of patients with ACAH. We describe an 11-year-old girl with CAH who developed life-threatening AH and was successfully managed with mechanical ventilation [...]

Published
1993

47. Development and Validation of a Symptom-Based Activity Index for Adults With Eosinophilic Esophagitis

Author

Leung, John, Locke, G. Richard, Drouin, Eric, Gonsalves, Nirmala, Spergel, Jonathan M., Wu, Tsung Teh, Alexander, Jeffrey A., Yang, Guang Yu, Chehade, Mirna, Maurer, Elisabeth, Dellon, Evan S., Aceves, Seema S., Butterfield, Joseph H., Krishna, Murli, Hirano, Ikuo, Crowell, Michael D., Gupta, Sandeep K., Straumann, Alex, Netzer, Peter, Zwahlen, Marcel, Armstrong, David, Kita, Hirohito, Kern, Emily, Taft, Tiffany H., Orbelo, Diana M., Yost, Kathleen J., De Petris, Giovanni, Katzka, David A., DeVault, Kenneth R., Lim, Kaiser, Ramirez, Francisco C., Lewis, John C., Guyatt, Gordon H., Moawad, Fouad J., Haas, Nadine A., Francis, Dawn L., Arora, Amindra S., Safroneeva, Ekaterina, Woosley, John T., Panczak, Radoslaw, Foxx-Orenstein, Amy, Enders, Felicity T., Harris, Lucinda A., Nguyen, Cuong C., Kagalwalla, Amir F., Murray, Joseph A., Achem, Sami R., Furuta, Glenn T., Lee, James J., Enav, Benjamin, Bussmann, Christian, Schoepfer, Alain M., Pasha, Shabana F., Sheikh, Javed, Collins, Margaret H., Romero, Yvonne, Fleischer, David E., Smyrk, Thomas C., Wo, John M., Attwood, Stephen E., Coslovsky, Michael, Yan, Pu, Alpan, Oral, Umar, Sarah B., Kuehni, Claudia E., and Weiler, Catherine R.

Abstract

Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE), to provide endpoints for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patients’ assessments of disease severity. We also evaluated relationships between patients’ assessment of disease severity and EoE-associated endoscopic, histologic, and laboratory findings.

Published
2014
Full Text
View/download PDF

49. Mo1185 Substantial Variability in Biopsy Practice Patterns Among Gastroenterologists for Suspected Eosinophilic Gastrointestinal Disorders (EGID)

Author

Dellon, Evan, primary, Collins, Margaret H., additional, Bonis, Peter A., additional, Capocelli, Kelley E., additional, Dohil, Ranjan, additional, Falk, Gary W., additional, Furuta, Glenn, additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Hiremath, Girish, additional, Kagalwalla, Amir F., additional, Leung, John, additional, Liacouras, Chris A., additional, Menard-Katcher, Calies D., additional, Muir, Amanda B., additional, Mukkada, Vincent A., additional, Putnam, Philip E., additional, Schoepfer, Alain M., additional, Straumann, Alex, additional, Wershil, Barry K., additional, Wo, John M., additional, Yang, Guang-Yu, additional, Rothenberg, Marc E., additional, and Gonsalves, Nirmala, additional

Published
2016
Full Text
View/download PDF

50. Esophageal Microbiome in Eosinophilic Esophagitis

Author

Harris, J. Kirk, Fang, R., Wagner, Brandie D., Choe, Ha Na, Kelly, Caleb J., Schroeder, Shauna, Moore, Wendy, Stevens, Mark J., Yeckes, Alyson, Amsden, Katie, Kagalwalla, Amir F., Zalewski, Angelika, Hirano, Ikuo, Gonsalves, Nirmala, Henry, Lauren N., Masterson, Joanne C., Robertson, Charles E., Leung, Donald Y., Pace, Norman R., Ackerman, Steven J., Furuta, Glenn T., Fillon, Sophie A., Harris, J. Kirk, Fang, R., Wagner, Brandie D., Choe, Ha Na, Kelly, Caleb J., Schroeder, Shauna, Moore, Wendy, Stevens, Mark J., Yeckes, Alyson, Amsden, Katie, Kagalwalla, Amir F., Zalewski, Angelika, Hirano, Ikuo, Gonsalves, Nirmala, Henry, Lauren N., Masterson, Joanne C., Robertson, Charles E., Leung, Donald Y., Pace, Norman R., Ackerman, Steven J., Furuta, Glenn T., and Fillon, Sophie A.

Abstract

Objective: The microbiome has been implicated in the pathogenesis of a number of allergic and inflammatory diseases. The mucosa affected by eosinophilic esophagitis (EoE) is composed of a stratified squamous epithelia and contains intraepithelial eosinophils. To date, no studies have identified the esophageal microbiome in patients with EoE or the impact of treatment on these organisms. The aim of this study was to identify the esophageal microbiome in EoE and determine whether treatments change this profile. We hypothesized that clinically relevant alterations in bacterial populations are present in different forms of esophagitis. Design: In this prospective study, secretions from the esophageal mucosa were collected from children and adults with EoE, Gastroesophageal Reflux Disease (GERD) and normal mucosa using the Esophageal String Test (EST). Bacterial load was determined using quantitative PCR. Bacterial communities, determined by 16S rRNA gene amplification and 454 pyrosequencing, were compared between health and disease. Results: Samples from a total of 70 children and adult subjects were examined. Bacterial load was increased in both EoE and GERD relative to normal subjects. In subjects with EoE, load was increased regardless of treatment status or degree of mucosal eosinophilia compared with normal. Haemophilus was significantly increased in untreated EoE subjects as compared with normal subjects. Streptococcus was decreased in GERD subjects on proton pump inhibition as compared with normal subjects. Conclusions: Diseases associated with mucosal eosinophilia are characterized by a different microbiome from that found in the normal mucosa. Microbiota may contribute to esophageal inflammation in EoE and GERD.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results