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Development and Validation of a Symptom-Based Activity Index for Adults With Eosinophilic Esophagitis

Authors :
Leung, John
Locke, G. Richard
Drouin, Eric
Gonsalves, Nirmala
Spergel, Jonathan M.
Wu, Tsung Teh
Alexander, Jeffrey A.
Yang, Guang Yu
Chehade, Mirna
Maurer, Elisabeth
Dellon, Evan S.
Aceves, Seema S.
Butterfield, Joseph H.
Krishna, Murli
Hirano, Ikuo
Crowell, Michael D.
Gupta, Sandeep K.
Straumann, Alex
Netzer, Peter
Zwahlen, Marcel
Armstrong, David
Kita, Hirohito
Kern, Emily
Taft, Tiffany H.
Orbelo, Diana M.
Yost, Kathleen J.
De Petris, Giovanni
Katzka, David A.
DeVault, Kenneth R.
Lim, Kaiser
Ramirez, Francisco C.
Lewis, John C.
Guyatt, Gordon H.
Moawad, Fouad J.
Haas, Nadine A.
Francis, Dawn L.
Arora, Amindra S.
Safroneeva, Ekaterina
Woosley, John T.
Panczak, Radoslaw
Foxx-Orenstein, Amy
Enders, Felicity T.
Harris, Lucinda A.
Nguyen, Cuong C.
Kagalwalla, Amir F.
Murray, Joseph A.
Achem, Sami R.
Furuta, Glenn T.
Lee, James J.
Enav, Benjamin
Bussmann, Christian
Schoepfer, Alain M.
Pasha, Shabana F.
Sheikh, Javed
Collins, Margaret H.
Romero, Yvonne
Fleischer, David E.
Smyrk, Thomas C.
Wo, John M.
Attwood, Stephen E.
Coslovsky, Michael
Yan, Pu
Alpan, Oral
Umar, Sarah B.
Kuehni, Claudia E.
Weiler, Catherine R.
Publication Year :
2014
Publisher :
The University of North Carolina at Chapel Hill University Libraries, 2014.

Abstract

Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE), to provide endpoints for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patients’ assessments of disease severity. We also evaluated relationships between patients’ assessment of disease severity and EoE-associated endoscopic, histologic, and laboratory findings.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi...........7b2cd58fb7c1d91a39ed48bb77c1033e
Full Text :
https://doi.org/10.17615/edkm-4w79
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