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Your search keyword '"Kadier, Aimaitiaji"' showing total 15 results
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15 results on '"Kadier, Aimaitiaji"'

2. CircCNOT6L modulates alternative splicing of SLC7A11 via splicing factor SRSF2 to confer ferroptosis resistance and promote metastasis in prostate cancer

Author

Yao, Xudong, primary, Liu, Ji, additional, Niraj, Maskey, additional, Zhu, Xiaojun, additional, Guo, Yadong, additional, Zhang, Zhijin, additional, Kadier, Aimaitiaji, additional, Gu, Zhuoran, additional, Wang, Hong, additional, Zou, Libin, additional, guo, changcheng, additional, Yang, Bin, additional, Zhang, Junfeng, additional, and Mao, Shiyu, additional

Published
2024
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3. Combined MRI-TRUS fusion targeted and systematic biopsy versus systematic biopsy alone for the detection of prostate cancer: protocol for a prospective single-centre trial

Author

Liu, Wujianhong, primary, Kadier, Aimaitiaji, additional, Shen, Danjing, additional, He, Yanyan, additional, Dong, Shengrong, additional, Zhu, Kun, additional, Xu, Guang, additional, Zhao, Binghui, additional, Mao, Shiyu, additional, Guo, Changcheng, additional, Yao, Xudong, additional, Wei, Qin, additional, Han, Dongyan, additional, and Yang, Bin, additional

Published
2024
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6. Effect of tumor CD276 expression on infiltrating immune cells and clinicopathological features of prostate cancer

Author

Liu, Ji, Kadier, Aimaitiaji, Guo, Yadong, Zhang, Wentao, Chen, Haotian, Zhang, Zhijin, Guo, Changcheng, Zhang, Yue, Bao, Meiyu, Geng, Jiang, Zhang, Junfeng, Mao, Shiyu, and Yao, Xudong

Abstract

Background: Advanced prostate cancer (PCa) is often resistant to immunotherapy. In this study, we examined the role of CD276 in mediating immunotherapeutic effects through changes in immune cell infiltration. Methods: Using transcriptomic and proteomic analyses, CD276 was identified as a potential target for immunotherapy. Subsequent in vivo and in vitro experiments confirmed its role as a potential mediator of immunotherapeutic effects. Results: Multi-omic analysis suggested that CD276 was identified as a key molecule regulating the immune microenvironment (IM). In vivo experiments revealed that CD276 knockdown was found to enhance CD8+T cell infiltration into the IM. Immunohistochemical analysis of PCa samples further confirmed the same findings. Conclusion: CD276 was found to inhibit the enrichment of CD8+ T cells in PCa. Thus, CD276 inhibitors may be potential targets for immunotherapy.

Published
2024
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8. O-GlcNAcylation Enhances NUSAP1 Stability and Promotes Bladder Cancer Aggressiveness

Author

Chen,Yifan, Liu,Ji, Zhang,Wentao, Kadier,Aimaitiaji, Wang,Ruiliang, Zhang,Haimin, Yao,Xudong, Chen,Yifan, Liu,Ji, Zhang,Wentao, Kadier,Aimaitiaji, Wang,Ruiliang, Zhang,Haimin, and Yao,Xudong

Abstract

Yifan Chen,* Ji Liu,* Wentao Zhang, Aimaitiaji Kadier,* Ruiliang Wang, Haimin Zhang, Xudong Yao Department of Urology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai, 200072, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xudong Yao; Haimin ZhangDepartment of Urology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, People’s Republic of ChinaEmail yaoxudong1967@163.com; zhm1064@163.comObjective: NUSAPl and O-GlcNAcylation were reported to be hyper-activated in many kinds of cancers and involved in the advanced progression of cancers. In bladder cancer, O-GlcNAc transferase (OGT) expresses in patients’ urine samples, with no expression in healthy individuals, indicating O-GlcNAcylation might involve in the occurrence and development of bladder cancer. Therefore, the present study aims to investigate the effects of O-GlcNAcylation in bladder cancer and if it can regulate NUSAP1 protein.Materials and Methods: Western blot, immunohistochemistry, and PCR were used to evaluate the protein expression and mRNA level of NUSAP1; CCK-8 and flow cytometry used to evaluate the proliferation and inhibited the apoptosis of bladder cancer.Results: The results showed that NUSAP1 was highly expressed in bladder cancer cells and tissue samples. NUSAP1 up-regulation significantly promoted the proliferation and inhibited the apoptosis of bladder cancer HT-1376 and T24 cells. Besides, the expression of O-GlcNAc was elevated in bladder cancer tissues and cells, and up-regulation of O-GlcNAc with GlcNAc and PuGNAc obviously increased NUSAP1 protein expression and stability. Moreover, knockdown OGT significantly inhibited the proliferation and tumorigenesis and promoted the apoptosis of bladder cancer cells, confirmed by CCK-8, in vivo xenotransplantation, and flow cytometry, whereas these roles were impaired when NUSAP1 was up-regulated.Con

Published
2021

15. Effect of tumor CD276 expression on infiltrating immune cells and clinicopathological features of prostate cancer.

Author

Liu J, Kadier A, Guo Y, Zhang W, Chen H, Zhang Z, Guo C, Zhang Y, Bao M, Geng J, Zhang J, Mao S, and Yao X

Abstract

Background: Advanced prostate cancer (PCa) is often resistant to immunotherapy. In this study, we examined the role of CD276 in mediating immunotherapeutic effects through changes in immune cell infiltration., Methods: Using transcriptomic and proteomic analyses, CD276 was identified as a potential target for immunotherapy. Subsequent in vivo and in vitro experiments confirmed its role as a potential mediator of immunotherapeutic effects., Results: Multi-omic analysis suggested that CD276 was identified as a key molecule regulating the immune microenvironment (IM). In vivo experiments revealed that CD276 knockdown was found to enhance CD8 + T cell infiltration into the IM. Immunohistochemical analysis of PCa samples further confirmed the same findings., Conclusion: CD276 was found to inhibit the enrichment of CD8+ T cells in PCa. Thus, CD276 inhibitors may be potential targets for immunotherapy., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

Published
2023
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