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3. 6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor

Author

Bohumila Fahmy, John H. Dodd, J. L. Pellegrino-Gensey, Druie Cavender, K. C. Rupert, Peter H. Schafer, John Siekierka, Scott Wadsworth, Janet E. Davis, Ignatius J. Turchi, J.R. Henry, and Gilbert C. Olini

Subjects
Lipopolysaccharides, Male, Stereochemistry, T-Lymphocytes, p38 mitogen-activated protein kinases, Aminopyridines, In Vitro Techniques, p38 Mitogen-Activated Protein Kinases, Chemical synthesis, Monocytes, Mice, chemistry.chemical_compound, Drug Discovery, Pyridine, Animals, Humans, Pyrroles, Enzyme Inhibitors, Protein kinase A, Tumor necrosis factor α, chemistry.chemical_classification, Mice, Inbred BALB C, biology, Bicyclic molecule, Tumor Necrosis Factor-alpha, Chemistry, Arthritis, Experimental, Rats, Enzyme, Rats, Inbred Lew, Enzyme inhibitor, Calcium-Calmodulin-Dependent Protein Kinases, biology.protein, Molecular Medicine, Mitogen-Activated Protein Kinases, Interleukin-1
Published
1998
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