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6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor
- Source :
- Journal of Medicinal Chemistry. 41:4196-4198
- Publication Year :
- 1998
- Publisher :
- American Chemical Society (ACS), 1998.
- Subjects :
- Lipopolysaccharides
Male
Stereochemistry
T-Lymphocytes
p38 mitogen-activated protein kinases
Aminopyridines
In Vitro Techniques
p38 Mitogen-Activated Protein Kinases
Chemical synthesis
Monocytes
Mice
chemistry.chemical_compound
Drug Discovery
Pyridine
Animals
Humans
Pyrroles
Enzyme Inhibitors
Protein kinase A
Tumor necrosis factor α
chemistry.chemical_classification
Mice, Inbred BALB C
biology
Bicyclic molecule
Tumor Necrosis Factor-alpha
Chemistry
Arthritis, Experimental
Rats
Enzyme
Rats, Inbred Lew
Enzyme inhibitor
Calcium-Calmodulin-Dependent Protein Kinases
biology.protein
Molecular Medicine
Mitogen-Activated Protein Kinases
Interleukin-1
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....6ec91e0e0a4564a76aeb07e79a0e6ebf
- Full Text :
- https://doi.org/10.1021/jm980497b