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Contarini syndrome refers to the presence of bilateral pleural effusions with different characteristics resulting from distinct aetiologies on each side. The syndrome was named after Francesco Contarini, the 95th Doge of Venice, who had right-sided transudative effusion possibly due to heart failure, and left-sided exudative effusion due to parapneumonic effusion. While bilateral pleural effusions typically exhibit similar characteristics and are secondary to the same underlying cause, such as heart failure or malignancy, there have been rare reports of bilateral effusions with different characteristics. In this case report, we present the case of a 53-year-old female with known breast carcinoma who presented with right-sided exudative pleural effusion and left-sided transudative pleural effusion, each with distinct aetiologies, thus establishing Contarini syndrome. This report highlights the importance of considering the possibility of two separate aetiologies for bilateral pleural effusions, which should not be overlooked in clinical practice.

Background: Resident doctors are working in a stressful environment continuously for prolonged period, which can lead to burnout syndrome. Objectives: The objective of this study was to find out the prevalence of burnout among resident doctors and to determine factors that are associated with burnout. Materials and Methods: This was a cross-sectional study that included 200 resident doctors working in different specialties of a tertiary care teaching hospital. The Copenhagen Burnout Inventory was used to measure burnout. A specially designed semi-structured questionnaire was used to collect sociodemographic details and other related factors. Results: In the present study, 52.5% of resident doctors had work-related burnout, 43% had personal burnout, and 36.5% had client-related burnout. Significantly higher burnout was seen in residents of younger age, 3rd-year residency, prolonged hours of continuous work, less hours of sleep, and clinical branches such as obstetrics and gynecology, medicine, and orthopedic. However, the study did not show any significant association of burnout with gender, marital status, and living with spouse/family. Conclusion: Resident doctors were found to have high rates of burnout. Age, year of residency, type of specialty, daily working hours, and sleeping hours were found to be associated with burnout.

Background: About 1.5 lakh students study in over 100 coaching centers in Kota. There is a highly competitive environment, and students often land up in stress and even suicide. So, the estimation of the magnitude of this problem and timely intervention can be of great value to students. Aim: This study aimed to assess and compare stress and coping strategies used by coaching and non-coaching students studying in Kota. Material and Methods: This cross-sectional study included 90 coaching and 90 non-coaching students fulfilling inclusion criteria that were specifically laid down for the study. A semi-structured specially designed pro forma, Scale of Academic Stress (SAS), and Coping Strategies Scale (CSS)-Hindi version were used. Appropriate statistical methods were then used to classify, tabulate, and analyze the collected data. Results: In this study, it was found that of all coaching students, 44.45% were suffering from high levels of academic stress, 34.44% suffered from average and 21.11% reported suffering from low levels of academic stress. Likewise, among non-coaching students, 70% were suffering from low academic stress, 26.67% from average, and 3.33% from high levels of academic stress. It was also evident that the majority of both coaching and non-coaching students used a low level of active coping strategy (cognitive approach, behavioral approach, and cognitive behavioral approach) and a high level of avoidance coping strategy (cognitive avoidance and behavioral avoidance). Conclusion: There is a significantly high prevalence of stress among coaching students as compared to non-coaching students. Stress levels of greater severity were found to be more prevalent in female students, 12th-class students, those belonging to urban and middle-class backgrounds, and those whose stream was chosen by their parents. Both coaching and non-coaching students used the same type of coping strategies to cope with stress.

Background: Head and neck cancer (HNC) is a profoundly distressing condition that can have significant psychological implications. It has the potential to impact various fundamental aspects of an individual's life, resulting in functional impairments and structural deformities depending on the location, size, and route of spread, therefore causing significant disability. Yet, this has not been adequately studied. People residing around areas around the atomic radiation power plant are exposed to radiation, and also, contamination of water sources, including the Chambal River, which is a major source of water needs of this area, may have a role in the pathogenesis and prognosis of cancer patients. Aim: This study aimed to study disability in patients with head and neck cancer before and after radiotherapy. Materials and Methods: This prospective observational study was conducted in association with the Department of Radiotherapy of a tertiary care hospital in Rajasthan. Fifty consecutive HNC patients aged 18 to 65 years fulfilling inclusion criteria, specifically laid down for the study, constituted the sample of the study. The World Health Organization Disability Assessment Schedule version 2.0 (WHODAS-2.0) was used. Results: The mean age of patients was 49.62 years. A statistically significant improvement after radiotherapy was found in disability scores in domains of cognition (2.39 vs. 1.88), self-care (2.39 vs. 1.78), and getting along with people domain (2.38 vs. 1.83). Conclusion: Disability improved significantly in patients after radiotherapy in the domains of self-care, getting along with people, and cognition.

Computer System Validation (CSV) is a critical aspect of ensuring that any software or system used in regulated environments, such as pharmaceuticals, healthcare, and biotechnology, meets its intended purpose and operates consistently within specified parameters. The UV spectroscopy instrument, specifically the CARRY UV software, is a pivotal tool in analytical laboratories for measuring the absorbance and transmission of ultraviolet and visible light by a sample. Validating this software using the V-Model ensures its reliability, accuracy, and compliance with regulatory standards. The V-Model, or Validation Model, is a systematic approach widely used in software development and validation. It emphasizes verification and validation activities corresponding to each stage of the software development lifecycle. Key aspects include accuracy in measurement, data integrity, user access controls, and audit trails. This stage involves outlining the software's capabilities, such as wavelength range, data processing algorithms, user interface design, and integration with laboratory information management systems (LIMS). The design specifications phase involves creating a blueprint for the software's architecture. This includes the design of databases, software modules, and user interfaces. For CARRY UV software, it is crucial to ensure that the design supports robust data handling, secure user access, and accurate data processing. For the CARRY UV software, developers must focus on implementing algorithms for accurate spectral data analysis and ensuring the software's compatibility with various hardware configurations. Integration testing involves combining individual modules and testing them as a group. System testing validates the complete and integrated software to ensure it meets the specified requirements. For the CARRY UV software, this involves testing the entire workflow from sample measurement to data analysis and reporting. It ensures the software performs reliably under different conditions and usage scenarios Users test the CARRY UV software in a real-world environment to ensure it performs as expected. This phase includes installation qualification (IQ), operational qualification (OQ), and performance qualification (PQ) to ensure the CARRY UV software is installed correctly, operates according to specifications, and performs consistently in the production environment. Throughout the validation process, meticulous documentation is maintained. This includes validation plans, test scripts, test results, and validation reports. Documentation is essential for demonstrating compliance with regulatory requirements, such as those set by the FDA, EMA, or other relevant authorities. Validating the CARRY UV software using the V Model ensures a structured and thorough approach to verifying and validating the software's functionality, performance, and compliance. This methodical process helps identify and mitigate risks early, ensuring the software's reliability and integrity in critical analytical applications. Through rigorous testing and documentation, the V Model supports the delivery of a robust and compliant UV spectroscopy instrument software, ultimately enhancing laboratory efficiency and accuracy. [ABSTRACT FROM AUTHOR]

Background: About 1.5 lakh students study in over 100 coaching centers in Kota. There is a highly competitive environment, and students often land up in stress and even suicide. So, the estimation of the magnitude of this problem and timely intervention can be of great value to students. Aim: This study aimed to assess and compare stress and coping strategies used by coaching and non-coaching students studying in Kota. Material and Methods: This cross-sectional study included 90 coaching and 90 non‑coaching students fulfilling inclusion criteria that were specifically laid down for the study. A semi-structured specially designed pro forma, Scale of Academic Stress (SAS), and Coping Strategies Scale (CSS)-Hindi version were used. Appropriate statistical methods were then used to classify, tabulate, and analyze the collected data. Results: In this study, it was found that of all coaching students, 44.45% were suffering from high levels of academic stress, 34.44% suffered from average and 21.11% reported suffering from low levels of academic stress. Likewise, among non-coaching students, 70% were suffering from low academic stress, 26.67% from average, and 3.33% from high levels of academic stress. It was also evident that the majority of both coaching and non-coaching students used a low level of active coping strategy (cognitive approach, behavioral approach, and cognitive behavioral approach) and a high level of avoidance coping strategy (cognitive avoidance and behavioral avoidance). Conclusion: There is a significantly high prevalence of stress among coaching students as compared to non-coaching students. Stress levels of greater severity were found to be more prevalent in female students, 12th-class students, those belonging to urban and middle-class backgrounds, and those whose stream was chosen by their parents. Both coaching and non-coaching students used the same type of coping strategies to cope with stress. [ABSTRACT FROM AUTHOR]

Background: Head and neck cancer (HNC) is a profoundly distressing condition that can have significant psychological implications. It has the potential to impact various fundamental aspects of an individual’s life, resulting in functional impairments and structural deformities depending on the location, size, and route of spread, therefore causing significant disability. Yet, this has not been adequately studied. People residing around areas around the atomic radiation power plant are exposed to radiation, and also, contamination of water sources, including the Chambal River, which is a major source of water needs of this area, may have a role in the pathogenesis and prognosis of cancer patients. Aim: This study aimed to study disability in patients with head and neck cancer before and after radiotherapy. Materials and Methods: This prospective observational study was conducted in association with the Department of Radiotherapy of a tertiary care hospital in Rajasthan. Fifty consecutive HNC patients aged 18 to 65 years fulfilling inclusion criteria, specifically laid down for the study, constituted the sample of the study. The World Health Organization Disability Assessment Schedule version 2.0 (WHODAS-2.0) was used. Results: The mean age of patients was 49.62 years. A statistically significant improvement after radiotherapy was found in disability scores in domains of cognition (2.39 vs. 1.88), self-care (2.39 vs. 1.78), and getting along with people domain (2.38 vs. 1.83). Conclusion: Disability improved significantly in patients after radiotherapy in the domains of self‑care, getting along with people, and cognition. [ABSTRACT FROM AUTHOR]

Hypoplasia of the lung is an uncommon congenital abnormality of the respiratory system in contrast to pulmonary agenesis. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the congenital absence of the upper two-thirds of the vagina and uterus with normal secondary sexual characteristics, ovary and normal karyotype. We report a 31-year-old female patient who presented in 2022 with cough with expectoration, left-side chest pain and breathlessness for 4 years to tertiary hospital, Puducherry, India. She was evaluated for amenorrhoea and diagnosed as MRKH syndrome and the patient underwent right-side oophorectomy for right ovarian torsion with a tumour. Computed tomography pulmonary angiogram and fiberoptic endoscopy were suggestive of left lung hypoplasia and the patient was advised symptomatic treatment for lung hypoplasia and planned for vaginoplasty for which she refused. [ABSTRACT FROM AUTHOR]