1. Guiding Ketogenic Diet with Breath Acetone Sensors
- Author
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Andreas T. Güntner, Julia F. Kompalla, Henning Landis, S. Jonathan Theodore, Bettina Geidl, Noriane A. Sievi, Malcolm Kohler, Sotiris E. Pratsinis, and Philipp A. Gerber
- Subjects
chemical sensor ,breath analysis ,semiconductor ,nanotechnology ,flame spray pyrolysis ,point-of-care ,biomedical ,Chemical technology ,TP1-1185 - Abstract
Ketogenic diet (KD; high fat, low carb) is a standard treatment for obesity, neurological diseases (e.g., refractory epilepsy) and a promising method for athletes to improve their endurance performance. Therein, the level of ketosis must be regulated tightly to ensure an effective therapy. Here, we introduce a compact and inexpensive breath sensor to monitor ketosis online and non-invasively. The sensor consists of Si-doped WO3 nanoparticles that detect breath acetone selectively with non-linear response characteristics in the relevant range of 1 to 66 ppm, as identified by mass spectrometry. When tested on eleven subjects (five women and six men) undergoing a 36-h KD based on the Johns Hopkins protocol, this sensor clearly recognizes the onset and progression of ketosis. This is in good agreement to capillary blood β-hydroxybutyrate (BOHB) measurements. Despite similar dieting conditions, strong inter-subject differences in ketosis dynamics were observed and correctly identified by the sensor. These even included breath acetone patterns that could be linked to low tolerance to that diet. As a result, this portable breath sensor represents an easily applicable and reliable technology to monitor KD, possibly during medical treatment of epilepsy and weight loss. more...
- Published
- 2018
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