1. Causal evidence for retina dependent and independent visual motion computations in mouse cortex
- Author
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Josephine Juettner, Daniel Hillier, Gergely Katona, Santiago B. Rompani, Michele Fiscella, Andreas Hierlemann, Antonia Drinnenberg, Balázs Rózsa, Zoltan Raics, Stuart Trenholm, and Botond Roska
- Subjects
0301 basic medicine ,Male ,genetic structures ,Motion Perception ,Sensory system ,Mice, Transgenic ,Stimulus (physiology) ,Visual system ,Article ,Retina ,Sensory processing and perception ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,medicine ,Premovement neuronal activity ,Animals ,Diphtheria Toxin ,Visual Pathways ,Motion perception ,Visual Cortex ,Computational Neuroscience ,Physics ,Mice, Knockout ,General Neuroscience ,Retinal ,Cytoskeletal Proteins ,030104 developmental biology ,medicine.anatomical_structure ,Visual cortex ,Amacrine Cells ,chemistry ,Female ,Neuroscience ,030217 neurology & neurosurgery ,Photic Stimulation - Abstract
How neuronal computations in the sensory periphery contribute to computations in the cortex is not well understood. We examined this question in the context of visual-motion processing in the retina and primary visual cortex (V1) of mice. We disrupted retinal direction selectivity, either exclusively along the horizontal axis using FRMD7 mutants or along all directions by ablating starburst amacrine cells, and monitored neuronal activity in layer 2/3 of V1 during stimulation with visual motion. In control mice, we found an over-representation of cortical cells preferring posterior visual motion, the dominant motion direction an animal experiences when it moves forward. In mice with disrupted retinal direction selectivity, the over-representation of posterior-motion-preferring cortical cells disappeared, and their responses at higher stimulus speeds were reduced. This work reveals the existence of two functionally distinct, sensory-periphery-dependent and -independent computations of visual motion in the cortex.
- Published
- 2017