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Causal evidence for retina dependent and independent visual motion computations in mouse cortex
- Source :
- Nature neuroscience, Nature Neuroscience
- Publication Year :
- 2017
-
Abstract
- How neuronal computations in the sensory periphery contribute to computations in the cortex is not well understood. We examined this question in the context of visual-motion processing in the retina and primary visual cortex (V1) of mice. We disrupted retinal direction selectivity, either exclusively along the horizontal axis using FRMD7 mutants or along all directions by ablating starburst amacrine cells, and monitored neuronal activity in layer 2/3 of V1 during stimulation with visual motion. In control mice, we found an over-representation of cortical cells preferring posterior visual motion, the dominant motion direction an animal experiences when it moves forward. In mice with disrupted retinal direction selectivity, the over-representation of posterior-motion-preferring cortical cells disappeared, and their responses at higher stimulus speeds were reduced. This work reveals the existence of two functionally distinct, sensory-periphery-dependent and -independent computations of visual motion in the cortex.
- Subjects :
- 0301 basic medicine
Male
genetic structures
Motion Perception
Sensory system
Mice, Transgenic
Stimulus (physiology)
Visual system
Article
Retina
Sensory processing and perception
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
medicine
Premovement neuronal activity
Animals
Diphtheria Toxin
Visual Pathways
Motion perception
Visual Cortex
Computational Neuroscience
Physics
Mice, Knockout
General Neuroscience
Retinal
Cytoskeletal Proteins
030104 developmental biology
medicine.anatomical_structure
Visual cortex
Amacrine Cells
chemistry
Female
Neuroscience
030217 neurology & neurosurgery
Photic Stimulation
Subjects
Details
- Language :
- English
- ISSN :
- 15461726 and 10976256
- Volume :
- 20
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Nature neuroscience
- Accession number :
- edsair.doi.dedup.....c651d5c37d00194da8a4459a9c52c091