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153 results on '"Joseph, J.M."'

2. Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients

Author

Gerber, F., Joseph, J.M., Crisinel, P.A., and Andrey, V.

Subjects
Ceftriaxone, General Medicine, Amoxicillin-Potassium Clavulanate Combination, Appendicitis, Anti-Bacterial Agents, Cohort Studies, Postoperative Complications, Clinical Protocols, Metronidazole, Acute Disease, Escherichia coli, Appendectomy, Humans, Child, Amoxicillin-Potassium Clavulanate Combination/therapeutic use, Anti-Bacterial Agents/therapeutic use, Appendicitis/complications, Appendicitis/drug therapy, Appendicitis/surgery, Ceftriaxone/therapeutic use, Metronidazole/therapeutic use, Postoperative Complications/microbiology, Retrospective Studies
Abstract

BACKGROUND: Acute appendicitis is the most frequent surgical emergency in the paediatric population. Complicated appendicitis accounts for 30% of cases and is inextricably linked to postoperative infectious complications. A study at our institution showed that amoxicillin-clavulanate resistant Escherichia coli in complicated appendicitis was significantly linked to postoperative infectious complications. These findings led to a change in the empirical antibiotic protocol (amoxicillin-clavulanate changed to ceftriaxone + metronidazole as of 2017), intending to reduce postoperative infectious complications in complicated appendicitis in our institution. AIM OF THE STUDY: This study aimed to analyse the microbiology and resistance profiles of pathogens of complicated appendicitis at our institution since implementing the new antibiotic protocol and the postoperative infectious complications rate. METHODS: We designed a retrospective comparative cohort study. During the defined study period (01 January 2017 to 31 July 2020), medical records were analysed for cases of acute appendicitis, complicated appendicitis and postoperative infectious complications, retaining only those who fulfilled inclusion criteria. Postoperative outcomes, microbiology and antibiotic resistance of peritoneal swabs were analysed. RESULTS: During the study period, 95 patients presented with a complicated appendicitis, and 11 (12%) developed postoperative infectious complications. The most frequent pathogens found in complicated appendicitis were E. coli (66%), Streptococcus anginosus (45%), and Bacteroides fragilis (22%). Pseudomonas aeruginosa was present in 17% of complicated appendicitis. Pathogens involved in postoperative infectious complications mirrored the distribution found in complicated appendicitis without postoperative infectious complications. Antibiotic susceptibility analysis showed that 10 (15%) of E. coli strains were resistant to amoxicillin-clavulanate but sensitive to ceftriaxone + metronidazole, with only one strain responsible for causing a postoperative infectious complication. Six additional strains of E. coli (9%) were resistant to amoxicillin-clavulanate and our empirical antibiotic regimen but were not associated with an increase in postoperative infectious complications. Compared with our previous study, there was a decrease in postoperative infectious complications from 16% to 12%. Postoperative infectious complications caused by amoxicillin-clavulanate-resistant E. coli decreased from 28% to 9%. CONCLUSION: This retrospective study demonstrated a decrease in the rate of postoperative infectious complications due to amoxicillin-clavulanate-resistant E. coli in complicated appendicitis. These findings accentuate the need to implement evidence-based treatment protocols based on local microbiology profiles and resistance rates to optimise post-operative antibiotics in complicated appendicitis.

Published
2022

3. Background studies for acoustic neutrino detection at the South Pole

Author

Abbasi, R., Abdou, Y., Abu-Zayyad, T., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., BenZvi, S., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D.J., Bohm, C., Bose, D., Böser, S., Botner, O., Braun, J., Brown, A.M., Buitink, S., Carson, M., Chirkin, D., Christy, B., Clem, J., Clevermann, F., Cohen, S., Colnard, C., Cowen, D.F., D’Agostino, M.V., Danninger, M., Daughhetee, J., Davis, J.C., De Clercq, C., Demirörs, L., Denger, T., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Díaz-Vélez, J.C., Dierckxsens, M., Dreyer, J., Dumm, J.P., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Fedynitch, A., Feusels, T., Filimonov, K., Finley, C., Fischer-Wasels, T., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Geisler, M., Gerhardt, L., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Goodman, J.A., Grant, D., Griesel, T., Groß, A., Grullon, S., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Heinen, D., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kenny, P., Kiryluk, J., Kislat, F., Klein, S.R., Köhne, J.-H., Kohnen, G., Kolanoski, H., Köpke, L., Kopper, S., Koskinen, D.J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Larson, M.J., Lauer, R., Lünemann, J., Madsen, J., Majumdar, P., Marotta, A., Maruyama, R., Mase, K., Matis, H.S., Meagher, K., Merck, M., Mészáros, P., Meures, T., Middell, E., Milke, N., Miller, J., Montaruli, T., Morse, R., Movit, S.M., Nahnhauer, R., Nam, J.W., Naumann, U., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., O’Murchadha, A., Ono, M., Panknin, S., Paul, L., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Porrata, R., Posselt, J., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Ruhe, T., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H.-G., Santander, M., Sarkar, S., Schatto, K., Schmidt, T., Schönwald, A., Schukraft, A., Schultes, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stössl, A., Stoyanov, S., Strahler, E.A., Straszheim, T., Stür, M., Sullivan, G.W., Swillens, Q., Taavola, H., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Tilav, S., Toale, P.A., Toscano, S., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Vehring, M., Voge, M., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Weaver, Ch., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C.H., Williams, D.R., Wischnewski, R., Wissing, H., Wolf, M., Woschnagg, K., Xu, C., Xu, X.W., Yanez, J.P., Yodh, G., Yoshida, S., and Zarzhitsk, P.

Published
2012
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4. Search for neutrino-induced cascades with five years of AMANDA data

Author

Abbasi, R., Abdou, Y., Abu-Zayyad, T., Actis, O., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bissok, M., Blaufuss, E., Boersma, D.J., Bohm, C., Böser, S., Botner, O., Bradley, L., Braun, J., Buitink, S., Carson, M., Chirkin, D., Christy, B., Clem, J., Clevermann, F., Cohen, S., Colnard, C., Cowen, D.F., D’Agostino, M.V., Danninger, M., Davis, J.C., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Díaz-Vélez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geisler, M., Gerhardt, L., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Goodman, J.A., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kemming, N., Kenny, P., Kiryluk, J., Kislat, F., Klein, S.R., Knops, S., Köhne, J.-H., Kohnen, G., Kolanoski, H., Köpke, L., Koskinen, D.J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Lehmann, R., Lennarz, D., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H.S., Matusik, M., Meagher, K., Merck, M., Mészáros, P., Meures, T., Middell, E., Milke, N., Miller, J., Montaruli, T., Morse, R., Movit, S.M., Nahnhauer, R., Nam, J.W., Naumann, U., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Paul, L., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Porrata, R., Posselt, J., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Ruhe, T., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H.-G., Sarkar, S., Schatto, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schultes, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stoyanov, S., Strahler, E.A., Straszheim, T., Sullivan, G.W., Swillens, Q., Taboada, I., Tamburro, A., Tepe, A., Ter-Antonyan, S., Tilav, S., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Voigt, B., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, C., Xu, X.W., Yodh, G., Yoshida, S., and Zarzhitsky, P.

Published
2011
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5. Measurement of acoustic attenuation in South Pole ice

Author

Abbasi, R., Abdou, Y., Abu-Zayyad, T., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bissok, M., Blaufuss, E., Boersma, D.J., Bohm, C., Böser, S., Botner, O., Bradley, L., Braun, J., Buitink, S., Carson, M., Chirkin, D., Christy, B., Clem, J., Clevermann, F., Cohen, S., Colnard, C., Cowen, D.F., D’Agostino, M.V., Danninger, M., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Díaz-Vélez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geisler, M., Gerhardt, L., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Goodman, J.A., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Gustafsson, L., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kemming, N., Kenny, P., Kiryluk, J., Kislat, F., Klein, S.R., Knops, S., Köhne, J.-H., Kohnen, G., Kolanoski, H., Köpke, L., Koskinen, D.J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Lehmann, R., Lennarz, D., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H.S., Matusik, M., Meagher, K., Merck, M., Mészáros, P., Meures, T., Middell, E., Milke, N., Montaruli, T., Morse, R., Movit, S.M., Nahnhauer, R., Nam, J.W., Naumann, U., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Paul, L., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Porrata, R., Posselt, J., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Ruhe, T., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H.-G., Sarkar, S., Schatto, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schultes, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stoyanov, S., Strahler, E.A., Straszheim, T., Sullivan, G.W., Swillens, Q., Taboada, I., Tamburro, A., Tarasova, O., Tepe, A., Ter-Antonyan, S., Tilav, S., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Voigt, B., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, C., Xu, X.W., Yanez, J.P., Yodh, G., Yoshida, S., and Zarzhitsky, P.

Published
2011
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6. The energy spectrum of atmospheric neutrinos between 2 and 200 TeV with the AMANDA-II detector

Author

Abbasi, R., Abdou, Y., Abu-Zayyad, T., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bissok, M., Blaufuss, E., Boersma, D.J., Bohm, C., Böser, S., Botner, O., Bradley, L., Braun, J., Buitink, S., Carson, M., Chirkin, D., Christy, B., Clem, J., Clevermann, F., Cohen, S., Colnard, C., Cowen, D.F., D’Agostino, M.V., Danninger, M., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Díaz-Vélez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Fedynitch, A., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geisler, M., Gerhardt, L., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Goodman, J.A., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kemming, N., Kenny, P., Kiryluk, J., Kislat, F., Klein, S.R., Knops, S., Köhne, J.-H., Kohnen, G., Kolanoski, H., Köpke, L., Koskinen, D.J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Lehmann, R., Lennarz, D., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H.S., Matusik, M., Meagher, K., Merck, M., Mészáros, P., Meures, T., Middell, E., Milke, N., Montaruli, T., Morse, R., Movit, S.M., Münich, K., Nahnhauer, R., Nam, J.W., Naumann, U., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Paul, L., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Porrata, R., Posselt, J., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Ruhe, T., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H.-G., Sarkar, S., Schatto, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schultes, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stoyanov, S., Strahler, E.A., Straszheim, T., Sullivan, G.W., Swillens, Q., Taboada, I., Tamburro, A., Tarasova, O., Tepe, A., Ter-Antonyan, S., Tilav, S., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Voigt, B., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, C., Xu, X.W., Yodh, G., Yoshida, S., and Zarzhitsky, P.

Published
2010
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7. Measurement of sound speed vs. depth in South Pole ice for neutrino astronomy

Author

Abbasi, R., Abdou, Y., Ackermann, M., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bissok, M., Blaufuss, E., Boersma, D.J., Bohm, C., Bolmont, J., Böser, S., Botner, O., Bradley, L., Braun, J., Breder, D., Castermans, T., Chirkin, D., Christy, B., Clem, J., Cohen, S., Cowen, D.F., D’Agostino, M.V., Danninger, M., Day, C.T., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Diaz-Velez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Edwards, W.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Gerhardt, L., Gladstone, L., Goldschmidt, A., Goodman, J.A., Gozzini, R., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hasegawa, Y., Heise, J., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Inaba, M., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kenny, P., Kiryluk, J., Kislat, F., Klein, S.R., Klepser, S., Knops, S., Kohnen, G., Kolanoski, H., Köpke, L., Kowalski, M., Kowarik, T., Krasberg, M., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Leich, H., Lennarz, D., Lucke, A., Lundberg, J., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H.S., McParland, C.P., Meagher, K., Merck, M., Mészáros, P., Middell, E., Milke, N., Miyamoto, H., Mohr, A., Montaruli, T., Morse, R., Movit, S.M., Münich, K., Nahnhauer, R., Nam, J.W., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Patton, S., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Pohl, A.C., Porrata, R., Potthoff, N., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Rutledge, D., Ryckbosch, D., Sander, H.-G., Sarkar, S., Satalecka, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stoufer, M.C., Stoyanov, S., Strahler, E.A., Straszheim, T., Sulanke, K.-H., Sullivan, G.W., Swillens, Q., Taboada, I., Tarasova, O., Tepe, A., Ter-Antonyan, S., Terranova, C., Tilav, S., Tluczykont, M., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., Vogt, C., Voigt, B., Walck, C., Waldenmaier, T., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebusch, C.H., Wiedemann, A., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, X.W., Yodh, G., and Yoshida, S.

Published
2010
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8. Calibration and characterization of the IceCube photomultiplier tube

Author

Abbasi, R., Abdou, Y., Abu-Zayyad, T., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bissok, M., Blaufuss, E., Boersma, D.J., Bohm, C., Botner, O., Bradley, L., Braun, J., Buitink, S., Carson, M., Chirkin, D., Christy, B., Clem, J., Cohen, S., Colnard, C., Cowen, D.F., D’Agostino, M.V., Danninger, M., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Díaz-Vélez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geisler, M., Gerhardt, L., Gladstone, L., Goldschmidt, A., Goodman, J.A., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hasegawa, Y., Haugen, J., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Inaba, M., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kemming, N., Kenny, P., Kiryluk, J., Kislat, F., Kitamura, N., Klein, S.R., Knops, S., Kohnen, G., Kolanoski, H., Köpke, L., Koskinen, D.J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Laundrie, A., Lehmann, R., Lennarz, D., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H.S., Matusik, M., Meagher, K., Merck, M., Mészáros, P., Meures, T., Middell, E., Milke, N., Miyamoto, H., Montaruli, T., Morse, R., Movit, S.M., Nahnhauer, R., Nam, J.W., Naumann, U., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Paul, L., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Pohl, A.C., Porrata, R., Posselt, J., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Robl, P., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H.-G., Sandstrom, P., Sarkar, S., Schatto, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schultes, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stoyanov, S., Strahler, E.A., Straszheim, T., Sullivan, G.W., Swillens, Q., Taboada, I., Tamburro, A., Tarasova, O., Tepe, A., Ter-Antonyan, S., Terranova, C., Tilav, S., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Voigt, B., Wahl, D., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, C., Xu, X.W., Yodh, G., Yoshida, S., and Zarzhitsky, P.

Published
2010
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10. The IceCube data acquisition system: Signal capture, digitization, and timestamping

Author

Abbasi, R., Ackermann, M., Adams, J., Ahlers, M., Ahrens, J., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Becka, T., Becker, J.K., Becker, K.-H., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bingham, B., Blaufuss, E., Boersma, D.J., Bohm, C., Bolmont, J., Böser, S., Botner, O., Braun, J., Breeder, D., Burgess, T., Carithers, W., Castermans, T., Chen, H., Chirkin, D., Christy, B., Clem, J., Cowen, D.F., D’Agostino, M.V., Danninger, M., Davour, A., Day, C.T., Depaepe, O., De Clercq, C., Demirörs, L., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Diaz-Velez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Edwards, W.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Gerhardt, L., Gladstone, L., Glowacki, D., Goldschmidt, A., Goodman, J.A., Gozzini, R., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hardtke, R., Hasegawa, Y., Haugen, J., Hays, D., Heise, J., Helbing, K., Hellwig, M., Herquet, P., Hickford, S., Hill, G.C., Hodges, J., Hoffman, K.D., Hoshina, K., Hubert, D., Huelsnitz, W., Hughey, B., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Inaba, M., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Jones, A., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kawai, H., Kelley, J.L., Kiryluk, J., Kislat, F., Klein, S.R., Kleinfelder, S., Klepser, S., Kohnen, G., Kolanoski, H., Köpke, L., Kowalski, M., Kowarik, T., Krasberg, M., Kuehn, K., Kujawski, E., Kuwabara, T., Labare, M., Laihem, K., Landsman, H., Lauer, R., Laundrie, A., Leich, H., Leier, D., Lewis, C., Lucke, A., Ludvig, J., Lundberg, J., Lünemann, J., Madsen, J., Maruyama, R., Mase, K., Matis, H.S., McParland, C.P., Meagher, K., Meli, A., Merck, M., Messarius, T., Mészáros, P., Minor, R.H., Miyamoto, H., Mohr, A., Mokhtarani, A., Montaruli, T., Morse, R., Movit, S.M., Münich, K., Muratas, A., Nahnhauer, R., Nam, J.W., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Patton, S., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Pohl, A.C., Porrata, R., Potthoff, N., Pretz, J., Price, P.B., Przybylski, G.T., Rawlins, K., Razzaque, S., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Robbins, W.J., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Rutledge, D., Ryckbosch, D., Sander, H.-G., Sarkar, S., Satalecka, K., Sandstrom, P., Schlenstedt, S., Schmidt, T., Schneider, D., Schulz, O., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Smith, A.J., Song, C., Sopher, J.E., Spiczak, G.M., Spiering, C., Stanev, T., Stezelberger, T., Stokstad, R.G., Stoufer, M.C., Stoyanov, S., Strahler, E.A., Straszheim, T., Sulanke, K.-H., Sullivan, G.W., Swillens, Q., Taboada, I., Tarasova, O., Tepe, A., Ter-Antonyan, S., Tilav, S., Tluczykont, M., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., Viscomi, V., Vogt, C., Voigt, B., Vu, C.Q., Wahl, D., Walck, C., Waldenmaier, T., Waldmann, H., Walter, M., Wendt, C., Westerhof, S., Whitehorn, N., Wharton, D., Wiebusch, C.H., Wiedemann, C., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, X.W., Yodh, G., and Yoshida, S.

Published
2009
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14. Measurements on subscale Y-Ba-Cu-O racetrack coils at 77 K and self-field

Author

Wang, X., Caspi, S., Cheng, D.W., Dietderich, D.R., Felice, H., Ferracin, P., Godeke, A., Joseph, J.M., Lizarazo, J., Prestemon, S.O., and Sabbi, G.

Subjects
Barium compounds -- Magnetic properties, Barium compounds -- Thermal properties, Copper oxide superconductors -- Magnetic properties, Copper oxide superconductors -- Thermal properties, Magnetic fields -- Analysis, Superconducting magnets -- Thermal properties, Superconducting magnets -- Design and construction, Yttrium -- Magnetic properties, Yttrium -- Thermal properties, Business, Electronics, Electronics and electrical industries
Published
2010

15. Instrumentation and quench protection for LARP [Nb.sub.3]Sn magnets

Author

Felice, H., Ambrosio, G., Chlachidze, G., Ferracin, P., Hafalia, R., Hannaford, R.C., Joseph, J.M., Lietzke, A.F., McInturff, A.D., Muratore, J.F., Prestemon, S., Sabbi, G.L., Schmalzle, J., Wanderer, P., and Wang, X.R.

Subjects
Niobium alloys -- Electric properties, Niobium alloys -- Magnetic properties, Particle accelerators -- Design and construction, Superconducting magnets -- Design and construction, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Metals -- Quenching, Metals -- Analysis, Business, Electronics, Electronics and electrical industries, European Organization for Nuclear Research. Large Hadron Collider -- Research
Published
2009

16. Use of high resolution DAQ system to aid diagnosis of HD2b, a high performance [Nb.sub.3]Sn dipole

Author

Lizarazo, J., Doering, D., Doolittle, L., Galvin, J., Caspi, S., Dietderich, D.R., Felice, H., Ferracin, P., Godeke, A., Joseph, J.M., Lietzke, A.F., Ratti, A., Sabbi, G.-L., Trillaud, F., Wang, X.R., and Zimmerman, S.

Subjects
Magnetic dipoles -- Analysis, Magnetic fields -- Analysis, Niobium alloys -- Magnetic properties, Niobium alloys -- Thermal properties, Niobium alloys -- Electric properties, Tin alloys -- Magnetic properties, Tin alloys -- Thermal properties, Tin alloys -- Electric properties, Business, Electronics, Electronics and electrical industries
Published
2009

17. Assembly and test of HD2, a 36 mm bore high field [Nb.sub.3]Sn dipole magnet

Author

Ferracin, P., Bingham, B., Caspi, S., Cheng, D.W., Dietderich, D.R., Felice, H., Godeke, A., Hafalia, A.R., Hannaford, C.R., Joseph, J.M., Lietzke, A.F., Lizarazo, J., Sabbi, G.L., Trillaud, F., and Wang, X.R.

Subjects
Magnetic dipoles -- Evaluation, Niobium alloys -- Electric properties, Niobium alloys -- Magnetic properties, Superconducting magnets -- Design and construction, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Business, Electronics, Electronics and electrical industries
Published
2009

18. Chromatism compensation in wide-band nulling interferometry for nulling interferometers

Author

Spronck, Julien, Pereira, Silvania F., and Braat, Joseph J.M.

Subjects
Interferometers -- Design and construction, Interferometry -- Analysis, Astronomy, Physics
Abstract

We introduce the concept of chromatism compensation in nulling interferometry that enables a high rejection ratio in a wide spectral band. Therefore the achromaticity condition considered in most nulling interferometers can be relaxed. We show that this chromatism compensation cannot be applied to a two-beam nulling interferometer, and we make an analysis of the particular case of a three-telescope OCIS codes: 120.3180, 350.1260.

Published
2006

19. On the selection of AGN neutrino source candidates for a source stacking analysis with neutrino telescopes

Author

Achterberg, A., Ackermann, M., Adams, J., Ahrens, J., Atlee, D.W., Bahcall, J.N., Bai, X., Baret, B., Bartelt, M., Barwick, S.W., Bay, R., Beattie, K., Becka, T., Becker, J.K., Becker, K.-H., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Blaufuss, E., Boersma, D.J., Bohm, C., Böser, S., Botner, O., Bouchta, A., Braun, J., Burgess, C., Burgess, T., Castermans, T., Chirkin, D., Clem, J., Collin, B., Conrad, J., Cooley, J., Cowen, D.F., D’Agostino, M.V., Davour, A., Day, C.T., De Clercq, C., Desiati, P., DeYoung, T., Dreyer, J., Duvoort, M.R., Edwards, W.R., Ehrlich, R., Ellsworth, R.W., Evenson, P.A., Fazely, A.R., Feser, T., Filimonov, K., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geenen, H., Gerhardt, L., Goldschmidt, A., Goodman, J.A., Greene, M.G., Grullon, S., Groß, A., Gunasingha, R.M., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hardtke, D., Hardtke, R., Harenberg, T., Hart, J.E., Hauschildt, T., Hays, D., Heise, J., Helbing, K., Hellwig, M., Herquet, P., Hill, G.C., Hodges, J., Hoffman, K.D., Hoshina, K., Hubert, D., Hughey, B., Hulth, P.O., Hultqvist, K., Hundertmark, S., Ishihara, A., Jacobsen, J., Japaridze, G.S., Jones, A., Joseph, J.M., Kampert, K.-H., Karle, A., Kawai, H., Kelley, J.L., Kestel, M., Kitamura, N., Klein, S.R., Klepser, S., Kohnen, G., Kolanoski, H., Köpke, L., Krasberg, M., Kuehn, K., Landsman, H., Lang, R., Leich, H., Leuthold, M., Liubarsky, I., Lundberg, J., Madsen, J., Mase, K., Matis, H.S., McCauley, T., McParland, C.P., Meli, A., Messarius, T., Mészáros, P., Minor, R.H., Miočinović, P., Miyamoto, H., Mokhtarani, A., Montaruli, T., Morey, A., Morse, R., Movit, S.M., Münich, K., Nahnhauer, R., Nam, J.W., Nießen, P., Nygren, D.R., Ögelman, H., Olbrechts, Ph., Olivas, A., Patton, S., Peña-Garay, C., Pérez de los Heros, C., Pieloth, D., Pohl, A.C., Porrata, R., Pretz, J., Price, P.B., Przybylski, G.T., Rawlins, K., Razzaque, S., Refflinghaus, F., Resconi, E., Rhode, W., Ribordy, M., Richter, S., Rizzo, A., Robbins, S., Rott, C., Rutledge, D., Sander, H.-G., Schlenstedt, S., Schneider, D., Seckel, D., Seo, S.H., Seunarine, S., Silvestri, A., Smith, A.J., Solarz, M., Song, C., Sopher, J.E., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Steffen, P., Steele, D., Stezelberger, T., Stokstad, R.G., Stoufer, M.C., Stoyanov, S., Sulanke, K.-H., Sullivan, G.W., Sumner, T.J., Taboada, I., Tarasova, O., Tepe, A., Thollander, L., Tilav, S., Toale, P.A., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Voigt, B., Wagner, W., Walck, C., Waldmann, H., Walter, M., Wang, Y.-R., Wendt, C., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, X.W., Yodh, G., Yoshida, S., Zornoza, J.D., and Biermann, P.L.

Published
2006
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20. Analysis, search, and classification for reflective ring-field projection systems

Author

Bal, Matthieu F., Bociort, Florian, and Braat, Joseph J.M.

Subjects
Projectors -- Testing, Projectors -- Evaluation, Computer projection equipment, Astronomy, Physics
Abstract

Extreme ultraviolet (EUV) lithography uses reflective ring-field projection systems. Geometrical obstruction limits the possible system configurations to small domains of the parameter space. We present an analysis, a search method, and a classification of these unobstructed domains. The exhaustive search method based on paraxial analysis provides an effective means for determining all possible design forms and for finding useful starting configurations for optimization. The approach is validated through comparison with finite ray tracing. OCIS codes: 080.2740, 110.3960, 340.7440.

Published
2003

21. Wave-front correction methods for extreme-ultraviolet multilayer reflectors

Author

Singh, Mandeep, Bal, Matthieu F., Braat, Joseph J.M., Joyeux, Denis, and Dinger, Udo

Subjects
Optics -- Research, Astronomy, Physics
Abstract

In this theoretical study we show that by removing or depositing additional multilayer (ML) periods of a thin-film interference coating, distortions in the reflected wave front induced by surface figure errors can be corrected. At [lambda] = 13.4 nm in the extreme-ultraviolet region the removal or deposition of a single period of the standard two-component molybdenum-silicon (Mo/Si) ML interference coating induces an effective phase change of magnitude 0.043 [pi] with respect to an identical optical thickness in vacuum. The magnitude of this wave-front shift can be enhanced with multicomponent MLs optimized for phase change on reflection. We briefly discuss the contributions of the shift in the effective reflection surface of the ML on the phase change. We also predict the feasibility of novel phase-shifting masks for subwavelength imaging applications. OCIS codes: 160.3900, 230.4170, 310.6860, 340.7470.

Published
2003

22. Deep nulling by means of multiple-beam recombination

Author

Mieremet, Arjan L. and Braat, Joseph J.M.

Subjects
Astronomy -- Observations, Interferometry -- Methods, Optics -- Research, Astronomy, Physics
Abstract

Direct detection of exoplanets is possible by use of a technique called nulling interferometry, which is based on destructive interference of light of the bright object and constructive interference of the faint object. In the infrared wavelength region, this implies that light of a star must be attenuated by a certain factor, the so-called rejection ratio, which typically equals [10.sup.6]. This can be achieved by use of phase shifters, which apply a phase shift of [pi] rad with an average error no greater than 2 mrad over a predefined wavelength region. For a 6-18-[micro]m wavelength interval, this is a tough constraint. We show that the 2-mrad constraint can be relaxed if more than two beams participate in the beam recombination. We focus our attention on dispersive phase shifters and show that rejection ratios beyond [10.sup.6] can be reached easily by use of a system of four or more apertures and simple dispersive phase shifters that consist of only one material. OCIS codes: 350.1260, 120.3180.

Published
2003

23. First year performance of the IceCube neutrino telescope

Author

Achterberg, A., Ackermann, M., Adams, J., Ahrens, J., Andeen, K., Atlee, D.W., Baccus, J., Bahcall, J.N., Bai, X., Baret, B., Bartelt, M., Barwick, S.W., Bay, R., Beattie, K., Becka, T., Becker, J.K., Becker, K.-H., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Blaufuss, E., Boersma, D.J., Bohm, C., Böser, S., Botner, O., Bouchta, A., Braun, J., Burgess, C., Burgess, T., Castermans, T., Cherwinka, J., Chirkin, D., Clem, J., Cowen, D.F., D’Agostino, M.V., Davour, A., Day, C.T., De Clercq, C., Demirörs, L., Desiati, P., DeYoung, T., Diaz-Velez, J.C., Dreyer, J., Duvoort, M.R., Edwards, W.R., Ehrlich, R., Eisch, J., Elcheikh, A., Ellsworth, R.W., Evenson, P.A., Fadiran, O., Fazely, A.R., Feser, T., Filimonov, K., Fox, B.D., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geenen, H., Gerhardt, L., Goldschmidt, A., Goodman, J.A., Gozzini, R., Greene, M.G., Grullon, S., Groß, A., Gunasingha, R.M., Gurtner, M., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hardtke, D., Hardtke, R., Harenberg, T., Hart, J.E., Haugen, J., Hauschildt, T., Hays, D., Heise, J., Helbing, K., Hellwig, M., Herquet, P., Hill, G.C., Hodges, J., Hoffman, K.D., Hoshina, K., Hubert, D., Hughey, B., Hulth, P.O., Hultqvist, K., Hundertmark, S., Hülß, J.-P., Ishihara, A., Jacobsen, J., Japaridze, G.S., Jones, A., Joseph, J.M., Kampert, K.-H., Karle, A., Kawai, H., Kelley, J.L., Kestel, M., Kitamura, N., Klein, S.R., Klepser, S., Kohnen, G., Kolanoski, H., Köpke, L., Krasberg, M., Kuehn, K., Landsman, H., Laundrie, A., Leich, H., Liubarsky, I., Lundberg, J., Mackenzie, C., Madsen, J., Mase, K., Matis, H.S., McCauley, T., McParland, C.P., Meli, A., Messarius, T., Mészáros, P., Miyamoto, H., Mokhtarani, A., Montaruli, T., Morey, A., Morse, R., Movit, S.M., Münich, K., Muratas, A., Nahnhauer, R., Nam, J.W., Nießen, P., Nygren, D.R., Ögelman, H., Olbrechts, Ph., Olivas, A., Patton, S., Peña-Garay, C., Pérez de los Heros, C., Pettersen, C., Piegsa, A., Pieloth, D., Pohl, A.C., Porrata, R., Pretz, J., Price, P.B., Przybylski, G.T., Rawlins, K., Razzaque, S., Refflinghaus, F., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Robbins, S., Rott, C., Rutledge, D., Sander, H.-G., Sandstrom, P., Sarkar, S., Schlenstedt, S., Schneider, D., Seckel, D., Seo, S.H., Seunarine, S., Silvestri, A., Smith, A.J., Solarz, M., Song, C., Sopher, J.E., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Steffen, P., Stezelberger, T., Stokstad, R.G., Stoufer, M.C., Stoyanov, S., Strahler, E.A., Sulanke, K.-H., Sullivan, G.W., Taboada, I., Tarasova, O., Tepe, A., Thollander, L., Tilav, S., Toale, P.A., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., Voigt, B., Wagner, W., Walck, C., Waldmann, H., Walter, M., Wang, Y.-R., Wendt, C., Whitney, M., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wisniewski, P., Wissing, H., Woschnagg, K., Xu, X.W., Yodh, G., Yoshida, S., and Zornoza, J.D.

Published
2006
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24. Limits on the muon flux from neutralino annihilations at the center of the Earth with AMANDA

Author

Achterberg, A., Ackermann, M., Adams, J., Ahrens, J., Andeen, K., Atlee, D.W., Bahcall, J.N., Bai, X., Baret, B., Bartelt, M., Barwick, S.W., Bay, R., Beattie, K., Becka, T., Becker, J.K., Becker, K.-H., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Blaufuss, E., Boersma, D.J., Bohm, C., Böser, S., Botner, O., Bouchta, A., Bouhali, O., Braun, J., Burgess, C., Burgess, T., Castermans, T., Chirkin, D., Clem, J., Conrad, J., Cooley, J., Cowen, D.F., D’Agostino, M.V., Davour, A., Day, C.T., De Clercq, C., Desiati, P., DeYoung, T., Diaz-Velez, J.C., Dreyer, J., Duvoort, M.R., Edwards, W.R., Ehrlich, R., Ekström, P., Ellsworth, R.W., Evenson, P.A., Fadiran, O., Fazely, A.R., Feser, T., Filimonov, K., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geenen, H., Gerhardt, L., Goldschmidt, A., Goodman, J.A., Gozzini, R., Greene, M.G., Grullon, S., Groß, A., Gunasingha, R.M., Gurtner, M., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hardtke, D., Hardtke, R., Harenberg, T., Hart, J.E., Hauschildt, T., Hays, D., Heise, J., Helbing, K., Hellwig, M., Herquet, P., Hill, G.C., Hodges, J., Hoffman, K.D., Hoshina, K., Hubert, D., Hughey, B., Hulth, P.O., Hultqvist, K., Hundertmark, S., Hülß, J.-P., Ishihara, A., Jacobsen, J., Japaridze, G.S., Jones, A., Joseph, J.M., Kampert, K.-H., Karle, A., Kawai, H., Kelley, J.L., Kestel, M., Klein, S.R., Klepser, S., Kohnen, G., Kolanoski, H., Köpke, L., Krasberg, M., Kuehn, K., Landsman, H., Leich, H., Leuthold, M., Liubarsky, I., Lundberg, J., Madsen, J., Marciniewski, P., Mase, K., Matis, H.S., McCauley, T., McParland, C.P., Meli, A., Messarius, T., Mészáros, P., Minaeva, Y., Miočinović, P., Miyamoto, H., Mokhtarani, A., Montaruli, T., Morey, A., Morse, R., Movit, S.M., Münich, K., Nahnhauer, R., Nam, J.W., Neunhöffer, T., Nießen, P., Nygren, D.R., Ögelman, H., Olbrechts, Ph., Olivas, A., Patton, S., Peña-Garay, C., Pérez de los Heros, C., Piegsa, A., Pieloth, D., Pohl, A.C., Porrata, R., Pretz, J., Price, P.B., Przybylski, G.T., Rawlins, K., Razzaque, S., Refflinghaus, F., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Robbins, S., Rodrı´guez Martino, J., Rott, C., Rutledge, D., Sander, H.-G., Schlenstedt, S., Schneider, D., Schwarz, R., Seckel, D., Seo, S.H., Seunarine, S., Silvestri, A., Smith, A.J., Solarz, M., Song, C., Sopher, J.E., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Steffen, P., Stezelberger, T., Stokstad, R.G., Stoufer, M.C., Stoyanov, S., Strahler, E.A., Sulanke, K.-H., Sullivan, G.W., Sumner, T.J., Taboada, I., Tarasova, O., Tepe, A., Thollander, L., Tilav, S., Toale, P.A., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Voigt, B., Wagner, W., Walck, C., Waldmann, H., Walter, M., Wang, Y.-R., Wendt, C., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, X.W., Yodh, G., Yoshida, S., and Zornoza, J.D.

Published
2006
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25. Discussion note by Prof. Joop Evers: Profile of new intercity transport

Author

Joseph J.M. Evers

Subjects
Transportation engineering, TA1001-1280
Abstract

The massive use of private cars causes serious problems. Despite parking problems and traffic congestions, for many the private car remains favourable. As an alternative, a new type of public intercity transport has been proposed, called Fast Transport on Request (FTR). Specific elements are: dedicated tracks for high speed bus driving between the cities; booking via Internet or intelligent telephone; intelligent logistics control reducing the number of stops and excluding detours; adaptive seats and digital facilities.

Published
2007
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26. Response by Prof. Joop Evers

Author

Joseph J.M. Evers

Subjects
Transportation engineering, TA1001-1280
Abstract

The remarks by professor Weidmann concern: (1) Trip booking (discussed in III); The unmanageable number of O/D-relations (discussed in I); (2) Relations with other PTmodalities (discussed in II); (3) Capacity (see I and Profile paper: ‘State of art of fast transport by buses’); (4) Political feasibility (discussed in V and VI); (5) Speed (discussed in II) and (6) Infrastructure (discussed in II, VI and VII). The remarks of professor Bookhuis concern: (1) FTR as an alternative for car travelling (discussed in IV) and (2) Opportunities (discussed in VII). The author thanks professor Brookhuis and professor Weidmann for their interesting and stimulating remarks.

Published
2007
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27. Fresnel diffraction effects in the frontlight for a liquid-crystal display

Author

de Pooter, Jacco A., Cornelissen, Hugo J., and Braat, Joseph J.M.

Subjects
Diffraction patterns -- Models, Liquid crystal displays -- Testing, Astronomy, Physics
Abstract

In a new type of illumination system for reflective liquid-crystal displays, the frontlight, unwanted shadows appear in certain viewing directions. It will be shown that for an accurate description of these shadows the geometrical optics approach is not satisfactory and that Fresnel diffraction has to be taken into account. A model for the diffraction effects was developed, and the predicted results correspond well to the measurements. In addition, some remarkable effects were explained from the theory of Fresnel zones. OCIS codes: 050.1940, 350.3950, 230.3990.

Published
2002

28. Nulling interferometry without achromatic phase shifters

Author

Mieremet, Arjan L. and Braat, Joseph J.M.

Subjects
Optics -- Usage, Interferometry -- Usage, Planets -- Observations, Astronomy -- Equipment and supplies, Astronomy, Physics
Abstract

In the infrared wavelength region, a typical star is approximately a million times brighter than the planet that surrounds it, which is a major problem when we attempt to detect exoplanets in a direct manner. Nulling interferometry is a technique that one can use to solve this problem by attenuating the stellar light and enhancing that of the planet. Generally, deep nulling is achieved by use of achromatic phase shifters (APSs). Unfortunately, the technology needed to build these APSs is not yet fully developed. We show that deep nulling can also be achieved by using delay lines only. We investigate the nulling depth as a function of the width of the wavelength interval and the number of telescopes. We also show that we can obtain nulling depths of less than [10.sup.-6], which are required for exoplanet detection. Furthermore, we investigate the properties of the transmission map and make a comparison between our system and an APS system.

Published
2002

30. Real-time hiring of vehicles for container transport

Author

Joseph J.M. Evers

Subjects
Transportation engineering, TA1001-1280
Abstract

This study concerns the deployment of large numbers of container transporting vehicles on a network consisting of (dedicated) roads and logistic sites such as container terminals. Each site is managed autonomously by a site manager. The fleet of vehicles is deployed by a fleet manager. On request of the site managers, the fleet manager allocates vehicles to be hired by the site managers. Next, within these allocations, each site manager issues transportation jobs and assigns these jobs to the allocated vehicles. The objective of the fleet manager is to avoid unpaid empty driving and to keep the size of its fleet just large enough the serve the demand for vehicles. The objective of the site managers is to minimize the operational costs. In this context a new coordination system is proposed to allocate vehicle capacity, operating on the basis of a win-win situation for all actors. The coordination takes place at two levels. One level concerns the drawing up of an adaptive fleet deployment plan. The other level resides under control of the individual site managers and concerns the assignment of transportation jobs to vehicles, given the allocations of the fleet deployment plan. Both use repetitive linear programming procedures. Small size simulation experiments show that the approach might be effective.

Published
2006
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32. Logistic chain modelling

Author

Slats, Piet A., Bhola, Bis, Evers, Joseph J.M., and Dijkhuizen, Gert

Subjects
Operations research -- Models, Logistics -- Models, Reengineering (Management) -- Models, Business, Business, general, Business, international
Abstract

The application of operations research models and techniques to business process reengineering and integration of different logistic procedures is investigated. Specifically, the concept of integrated logistic chain modelling is reviewed. To optimize the turnaround time of the total logistic chain, two logistic laboratories were developed. One is the TASTE simulation tool while the other is a distribution planning support system.

Published
1995

36. Shaping with fluid jet polishing by footprint optimization

Author

Booij, Silvia M., Fahnle, Oliver W., and Braat, Joseph J.M.

Subjects
Optics, Astronomy, Physics
Abstract

We report on a way to shape surfaces with fluid jet polishing by adjusting the influence function (the shape of the footprint of the nozzle) instead of changing the dwell time of the nozzle on the surface. In that way, the surface is processed homogeneously, and no dip is generated in the center of the workpiece. As a proof of this approach, a [lambda]/10 flat surface has been generated in our laboratory. OCIS codes: 220.4610, 240.6700.

Published
2004

37. The 'Just Right' amount of oxygen improving oxygen use in a Rwandan emergency department

Author

Sutherland, Tori, Moriau, Victor, Niyonzima, Joseph J.M., Mueller, Ariel, Kabeja, Lise, Twagirumugabe, Theogene, Rosenberg, Noah, Umuhire, Olivier Félix, Talmor, Daniel, Riviello, Elisabeth E.D., Sutherland, Tori, Moriau, Victor, Niyonzima, Joseph J.M., Mueller, Ariel, Kabeja, Lise, Twagirumugabe, Theogene, Rosenberg, Noah, Umuhire, Olivier Félix, Talmor, Daniel, and Riviello, Elisabeth E.D.

Abstract

Rationale: Despite oxygen's classification as an essential medication by the World Health Organization, it is inconsistently available in many resource-constrained settings. Hypoxemia is associated with increased mortality, and mounting evidence suggests that hyperoxia may also be associated with adverse outcomes. Objectives: To determine if overuse of oxygen for some patients in a Rwandan tertiary care hospital emergency department might coexist with oxygen shortages and underuse of oxygen for other patients, and whether an educational intervention coupled with provision of pulse oximeters could improve the distribution of limited oxygen resources. Methods: We screened all patients in the adult emergency department (ED) of the University Teaching Hospital of Kigali for hypoxemia and receipt of oxygen therapy for 5 weeks. After completing baseline data collection, we provided pulse oximeters and conducted a didactic training with pre- and posttests on oxygen titration, with a chosen target oxygen saturation (SpO2) of 90% to 95%. Four and 12 weeks after the intervention, we evaluated all patients in the ED again for SpO2and receipt of oxygen therapy for 4 weeks each period.We also recorded ED oxygen use and availability of reserve oxygen for the hospital during the three study periods. Results: During all data collection periods, 214 of 1,765 (12.1%) unique patients screened were hypoxemic. The proportion of patient-days with appropriately titrated oxygen therapy (SpO2, 90-95%) increased from 18.7% at baseline to 38.5% and 42.0% at 4 and 12 weeks postintervention (P<0.001). On a multiple-choice examination testing knowledge of appropriate oxygen titration, clinicians' scores improved from average 60% (interquartile range [IQR], 40-80%) correct to 80% (IQR, 60-80%) correct immediately after the educational intervention (P<0.001). Oxygen use in the ED decreased from amedian of 32.0 (IQR, 28.0-35.0) tanks per day to 25.5 (IQR, 24.0-29.0) and 16.0 (IQR, 12.5-21.0) tanks, SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2019

38. Strehl ratio and optimum focus of high-numerical-aperture beams

Author

Janssen Augustus J.E.M., van Haver Sven, Braat Joseph J.M., and Dirksen Peter

Subjects
vector diffraction, aberrations, strehl ratio, high-numerical-aperture beams, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

We analytically calculate the focus setting for a beam with a high numerical aperture (NA) that optimizes its Strehl ratio in the case of small aberrations up to the ’just’ diffraction-limited value (Strehl ratio ≥0.80). The optimum focus setting deviates from the one that follows from a minimization of the wavefront aberration with the aid of the Zernike aberration coefficients. This deviation stems largely from the fact that the common quadratic approximation of the focus term becomes inadequate in the high-NA case. Fundamental high-NA amplitude nonuniformity in the exit pupil of an optical system in the case of a linearly polarized incident beam also influences the optimum focus setting. Results for spherical aberration and astigmatism are presented for an NA-value of 0.95.

Published
2007
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39. iTIRM as a tool for qualifying polishing processes

Author

Fahnle, Oliver W., Wons, Torsten, Koch, Evelyn, Debruyne, Sebastien, Meeder, Mark, Booij, Silvia M., and Braat, Joseph J.M.

Subjects
Grinding and polishing -- Equipment and supplies, Astronomy, Physics
Abstract

We report on what we believe to be a novel classification method for polishing processes that we apply in our laboratory on a regular basis. Two parameters are deduced from the in situ iTIRM (intensity-detecting total-internal-reflection microscopy) measurement method. Contrary to Preston's law, which gives the removal rate, the parameters of the iTIRM process are a measure of the change in surface quality (roughness, subsurface damage, and scratch and dig) and the duration of the polishing process. OCIS codes: 120.4800, 120.4630, 220.5450, 120.4610, 120.4290.

Published
2002

40. Comparison of beam combiners for a synthetic aperture imaging telescope

Author

van der Avoort Casper, Pereira Silvania F., Braat Joseph J.M., and den Herder Jan-Willem

Subjects
coherence imaging, partial coherence in imaging, phased-array imaging systems, telescopes, astronomical optics, space optics, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

Future astronomical space missions will comprise a constellation of several optical telescopes to detect exo-planets by interferometric nulling of starlight. The Darwin mission of the European Space Agency (ESA) and NASAs Terrestrial Planet Finder Interferometer both consist of a free-flying collection of telescopes and a beam combiner. As such, the constellation provides a co-phased array of telescopes that can also be used for aperture synthesis imaging. This imaging technique relies on recording intensity interference patterns, in which the layout of the beam combination optics and the detector play a key role. Several designs for beam combination have been proposed in the literature. In this article, we compare these beam combiners by rigorously simulating the imaging process of a weak stellar source, taking into account the photon arrival statistics, an imperfect detection process and the image reconstruction from the recorded data. The results are presented as the to be expected reconstruction error in the luminous intensity distribution function of a wide-field stellar source versus the provided amount of photons. Using these results, the optimum design of the combination beam combiner and detector array can be identified.

Published
2006
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42. Variability in body mass index (BMI) during adjuvant chemotherapy is associated with clinical outcomes among invasive ovarian cancer patients

Author

Starbuck, K., primary, Cannioto, R.A., additional, Etter, J.L., additional, Moysich, K.B., additional, Duncan, W., additional, Morrell, K., additional, Almohanna, H., additional, Joseph, J.M., additional, Szender, J.B., additional, Zsiros, E., additional, Odunsi, K., additional, Frederick, P.J., additional, Lele, S.B., additional, Akers, S.N., additional, and Eng, K.H., additional

Published
2018
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45. Gonadotropin-releasing hormone agonists during chemotherapy for preservation of ovarian function and fertility in premenopausal patients with early breast cancer: A systematic review and meta-analysis of individual patient–level data

Author

Lambertini, Matteo, Moore, Halle C F, Leonard, Robert Cf R.C.F., Loibl, Sibylle, Munster, Pamela, Bruzzone, Marco, Boni, Luca, Unger, Joseph J.M., Anderson, Richard Allen, Mehta, Keyur, Minton, Susan, Poggio, Francesca, Albain, Kathy S, Adamson, Douglas D.J.A., Gerber, Bernd, Cripps, Amy, Bertelli, Gianfilippo, Seiler, Sabine, Ceppi, Marcello, Partridge, Ann A.H., Del Mastro, Lucia, Lambertini, Matteo, Moore, Halle C F, Leonard, Robert Cf R.C.F., Loibl, Sibylle, Munster, Pamela, Bruzzone, Marco, Boni, Luca, Unger, Joseph J.M., Anderson, Richard Allen, Mehta, Keyur, Minton, Susan, Poggio, Francesca, Albain, Kathy S, Adamson, Douglas D.J.A., Gerber, Bernd, Cripps, Amy, Bertelli, Gianfilippo, Seiler, Sabine, Ceppi, Marcello, Partridge, Ann A.H., and Del Mastro, Lucia

Abstract

Purpose The role of temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy as a strategy to preserve ovarian function and fertility in premenopausal women remains controversial. This systematic review and meta-analysis using individual patient–level data was conducted to better assess the efficacy and safety of this strategy in patients with early breast cancer. Methods The trials in which premenopausal women with early breast cancer were randomly assigned to receive (neo)adjuvant chemotherapy alone or with concurrent GnRHa were eligible for inclusion. Primary end points were premature ovarian insufficiency (POI) rate and post-treatment pregnancy rate. Disease-free survival and overall survival were secondary end points. Because each study represents a cluster, statistical analyses were performed using a random effects model. Results A total of 873 patients from five trials were included. POI rate was 14.1% in the GnRHa group and 30.9% in the control group (adjusted odds ratio, 0.38; 95% CI, 0.26 to 0.57; P, 001). A total of 37 (10.3%) patients had at least one post-treatment pregnancy in the GnRHa group and 20 (5.5%) in the control group (incidence rate ratio, 1.83; 95% CI, 1.06 to 3.15; P = .030). No significant differences in disease-free survival (adjusted hazard ratio, 1.01; 95% CI, 0.72 to 1.42; P = .999) and overall survival (adjusted hazard ratio, 0.67; 95% CI, 0.42 to 1.06; P = .083) were observed between groups. Conclusion Our findings provide evidence for the efficacy and safety of temporary ovarian suppression with GnRHa during chemotherapy as an available option to reduce the likelihood of chemotherapy-induced POI and potentially improve future fertility in premenopausal patients with early breast cancer., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2018

47. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

Author

Hampras, S.S., Sucheston-Campbell, L.E., Cannioto, R., Chang-Claude, J., Modugno, F., Dork, T., Hillemanns, P., Preus, L., Knutson, K.L., Wallace, P.K., Hong, C.C., Friel, G., Davis, W., Nesline, M., Pearce, C.L., Kelemen, L.E., Goodman, M.T., Bandera, E.V., Terry, K.L., Schoof, N., Eng, K.H., Clay, A., Singh, P.K., Joseph, J.M., Aben, K.K.H., Anton-Culver, H., Antonenkova, N., Baker, H., Bean, Y., Beckmann, M.W., Bisogna, M., Bjorge, L., Bogdanova, N., Brinton, L.A., Brooks-Wilson, A., Bruinsma, F., Butzow, R., Campbell, I.G., Carty, K., Cook, L.S., Cramer, D.W, Cybulski, C., Dansonka-Mieszkowska, A., Dennis, J., Despierre, E., Dicks, E., Doherty, J.A., Bois, A. du, Durst, M., Easton, D., Eccles, D., Edwards, R.P., Ekici, A.B., Fasching, P.A., Fridley, B.L., Gao, Y.T., Gentry-Maharaj, A., Giles, G.G., Glasspool, R., Gronwald, J., Harrington, P., Harter, P., Hasmad, H.N., Hein, A., Heitz, F., Hildebrandt, M.A.T., Hogdall, C., Hogdall, E., Hosono, S., Iversen, E.S., Jakubowska, A., Jensen, A., Ji, B.T., Karlan, B.Y., Kellar, M., Kelley, J.L., Kiemeney, L.A.L.M., Klapdor, R., Kolomeyevskaya, N., Krakstad, C., Kjaer, S.K., Kruszka, B., Kupryjanczyk, J., Lambrechts, D., Lambrechts, S., Le, N.D., Lee, A.W., Lele, S., Leminen, A., Lester, J., Levine, D.A., Liang, D., Lissowska, J., Liu, S., Lu, K., Lubinski, J., Lundvall, L., Massuger, L.F.A.G., Matsuo, K., McGuire, V., et al., Hampras, S.S., Sucheston-Campbell, L.E., Cannioto, R., Chang-Claude, J., Modugno, F., Dork, T., Hillemanns, P., Preus, L., Knutson, K.L., Wallace, P.K., Hong, C.C., Friel, G., Davis, W., Nesline, M., Pearce, C.L., Kelemen, L.E., Goodman, M.T., Bandera, E.V., Terry, K.L., Schoof, N., Eng, K.H., Clay, A., Singh, P.K., Joseph, J.M., Aben, K.K.H., Anton-Culver, H., Antonenkova, N., Baker, H., Bean, Y., Beckmann, M.W., Bisogna, M., Bjorge, L., Bogdanova, N., Brinton, L.A., Brooks-Wilson, A., Bruinsma, F., Butzow, R., Campbell, I.G., Carty, K., Cook, L.S., Cramer, D.W, Cybulski, C., Dansonka-Mieszkowska, A., Dennis, J., Despierre, E., Dicks, E., Doherty, J.A., Bois, A. du, Durst, M., Easton, D., Eccles, D., Edwards, R.P., Ekici, A.B., Fasching, P.A., Fridley, B.L., Gao, Y.T., Gentry-Maharaj, A., Giles, G.G., Glasspool, R., Gronwald, J., Harrington, P., Harter, P., Hasmad, H.N., Hein, A., Heitz, F., Hildebrandt, M.A.T., Hogdall, C., Hogdall, E., Hosono, S., Iversen, E.S., Jakubowska, A., Jensen, A., Ji, B.T., Karlan, B.Y., Kellar, M., Kelley, J.L., Kiemeney, L.A.L.M., Klapdor, R., Kolomeyevskaya, N., Krakstad, C., Kjaer, S.K., Kruszka, B., Kupryjanczyk, J., Lambrechts, D., Lambrechts, S., Le, N.D., Lee, A.W., Lele, S., Leminen, A., Lester, J., Levine, D.A., Liang, D., Lissowska, J., Liu, S., Lu, K., Lubinski, J., Lundvall, L., Massuger, L.F.A.G., Matsuo, K., McGuire, V., and et al.

Abstract

Contains fulltext : 167177.pdf (publisher's version ) (Open Access), BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients. RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid (p = 0.082) and clear cell (p = 0.083), with the most significant gene level association seen with TGFBR2 (p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 (p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA (p = 0.035, endometrioid and mucinous), LGALS1 (p = 0.03, mucinous), STAT5B (p = 0.022, clear cell), TGFBR1 (p = 0.021 endometrioid) and TGFBR2 (p = 0.017 and p = 0.025, endometrioid and mucinous, respectively). CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.

Published
2016

49. Discussion note by Prof. Joop Evers: Profile of new intercity transport

Author

Evers, Joseph J.M.

Subjects
Transportation engineering, TA1001-1280, lcsh:TA1001-1280, lcsh:Transportation engineering
Abstract

The massive use of private cars causes serious problems. Despite parking problems and traffic congestions, for many the private car remains favourable. As an alternative, a new type of public intercity transport has been proposed, called Fast Transport on Request (FTR). Specific elements are: dedicated tracks for high speed bus driving between the cities; booking via Internet or intelligent telephone; intelligent logistics control reducing the number of stops and excluding detours; adaptive seats and digital facilities., European Journal of Transport and Infrastructure Research, Vol 7 No 3 (2007)

Published
2007

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