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3. Humoral response after the fourth dose of the SARS-CoV-2 vaccine in the CKD spectrum

Author

Borja, Quiroga, María José, Soler, Alberto, Ortiz, Carlos Jesús, Jarava Mantecón, Virginia Olinda, Gomes Pérez, Antoni, Bordils, José, Lacueva, Antonio José, Marin Franco, Pablo, Delgado Conde, Patricia, Muñoz Ramos, Carmen, Calderón González, Juan Manuel, Cazorla López, Jinny, Sanchez-Rodriguez, Ana, Sánchez Horrillo, Tania Raquel, Monzón Vázquez, Alba, Leyva, José, Rojas, Ron T, Gansevoort, Patricia, de Sequera, María Teresa Jaldo, Rodríguez, Rafael Lucena, Valverde, Marta Puerta, Carretero, Mayra Ortega, Díaz, Daniel Gaitán, Tocora, Esther Rodriguez, Suárez, Alfredo José Sáenz, Santolaya, Patricia Arribas, Cobo, Tamar, Talavan, Raquel Cerrajero, Calero, Carolina, Gracia-Iguacel, Emilio, González-Parra, Mónica, Pereira, Catalina, Martin-Cleary, Ana, Ramos-Verde, Martín, Giorgi, Carmen, Sánchez, Yohana Gil, Giraldo, Ana Sánchez, Horrillo, Pablo Ruano, Suárez, Antonio Fernández, Perpén, Andrés Fernández, Ramos, Laura Salanova, Villanueva, Alejandra, Cortiñas, Pablo A Díez, Arias, Alicia Cabrera, Cárdenas, Antonio, de Santos, Almudena, Núñez, Guillermina Barril, Cuadrado, Loreto Mariscal, de Gante, Raquel, Repollet, Concepción Redondo, Polo, Francesc, Moreso, María Antonieta, Azancot, Natalia, Ramos, Oriol Bestard Nestor, Toapanta, Ignacio, Cidraque, Sheila, Bermejo, Irene, Agraz, Oreto, Prat, Carlota, Medina, Emma, Pardo, Alejandro, Saiz, Maria Antònia Munar, Vila, Secundino Cigarrán, Guldris, Nicolás Menéndez, Granados, María Jesús Corton, Cabo, Walter López, Alarcón, Soledad Pizarro, Sánchez, Simona, Alexandru, Laura García Puente, Suarez, Saul Pampa, Saico, Marisol Poma, Tapia, Rocío, Zamora, Rosa Sánchez, Hernández, Laura Rodríguez, Osorio, Nuria, García-Fernández, Paloma Leticia Martin, Moreno, Noelia Ania, González, Ana Sabalza, Ortiz, María Nieves Bastida, Iñarrea, Sagrario Soriano, Cabrera, Raquel Ojeda, López, Cayetana Moyano, Peregrí, Maria Luisa Agüera, Morales, Maria Dolores Navarro, Cabello, Auxiliadora, Mazuecos, Teresa, García, Carlos, Narváez, Cristhian, Orellana, María Gabriela Sánchez, Márquez, Carolina Lancho, Novillo, Pedro Luis Quirós, Ganga, Fernando Vallejo, Carrión, Antonio Luis García, Herrera, Natalia Blanco, Castro, Rosa María Ruiz-Calero, Cendrero, María Victoria Martín, Hidalgo-Barquero, Román Hernández, Gallego, Álvaro, Alvarez, Eva Vázquez, Leo, José Luis Pizarro, León, Manuel Antonio Martínez, García, Benaldina García, Jiménez, Virginia Olinda Gómez, Pérez, Juan, de Dios Ramiro Moya, Diana López, Espinosa, Alejandro Jiménez, Herrador, Manuel Navarro, Zurita, Leonardo Díaz, Álvarez, Álvaro González, Martínez, Sandra Báez, Arroyo, Raquel Reina, Fernández, Marlyn Janella Suárez, Vargas, Rocío Calurano, Casero, Gustavo, Useche, Amparo Bernat, García, Ana Beatriz Muñoz, Díaz, Carmen Santamaría, de Miguel, Ángel, Palacios, Brenda, Henningsmeyer, Esther Orero, Calve, José Lacueva, Moya, Yurika, Sato, Marta Serra, Marín, Sandra, Tejedor, Shaida Martínez, Vaquera, Manuel Carnerero, di Riso, Irene, Torres, Georgina, Alfaro, Olga, Halauko, Fouad E L, Rifai, Ana Dolores, Martínez, Pablo Justo, Ávila, Christian Alfaro, Sánchez, Marta Sanz, Sainz, José María Baltar, Martín, Laura, Del Río García, José Luis Pérez, Canga, Paola Milena Villabón, Ochoa, Laura Muñiz, Pacios, Lina León, Machado, Augusto Quiroz, Morales, Ignacio Manzur, Cavalotti, Itziar Navarro, Zorita, Sol Otero, López, Sara Outon, González, Carlos Soto, Montañez, Auxiliadora Bajo, Rubio, Gloria, Del Peso Gilsanz, Marta Ossorio, Gonzalez, Rafael Sánchez, Villanueva, Maria Ovidia Lopez, Oliva, Jesús Calviño, Varela, Alba García, Enríquez, Carmen Cobelo, Casas, Pablo Otero, Alonso, Lourdes González, Tabares, José María Lamas, Barreiro, Luisa Palomares, Solla, Arginino, Gándara, Walfred Nájera, de la Garza, Francisco Fernández, Fleming, María Gloria Rodríguez, Goyanes, Cintia Caramés, Feijoo, María Mercedes Moreiras, Plaza, Cristina Bayón, Juan, Gabriel de Arriba, de la Fuente, Katia Pérez, Del Valle, Francisco Javier Pérez, Contreras, Noelia Balibrea, Lara, Dioné González, Ferri, Eduardo Muñoz, de Bustillo Llorente, Enriqueta González, Rodríguez, Virginia Lopez, De La Manzanara Perez, Marta Calvo, Arevalo, Jose Antonio Herrero, Calvo, María Rosario Llópez, Carratalá, Leyre María Martin, Rodríguez, Marisa Serrano, Salazar, Begoña Bravo, Prieto, José María Portolés, Pérez, Antonio Gil, Paraíso, Emma, Huarte, M, Lanau, Rodrigo Avellaneda, Campos, José Manuel, Ubé, Isabel Berdud, Godoy, Esther Torres, Aguilera, Rolando Tello, Alea, Margie Soledad, Del Rosario Saldaña, Mercedes, Salgueira, Nuria, Aresté, María, de Los Ángeles Rodríguez, Rocío, Collantes, Ana Isabel, Martínez, María Jesús, Moyano, Elena Jiménez, Víbora, Sandra Castellano, Gash, Lara Ruíz, Martínez, María Cinta Aguilar, Cervera, María Teresa Rodrigo, De Tomas, Beatriz Azcue, Prieto, Carmen, Toyos, José Molina, Del Rio, Adriana Restrepo, Acosta, Amagoia Celayeta, Zamacona, Ma Isabel Jimeno, Martin, Saioa Bilbao, Ortega, Ma Isabel Gallardo, Ruiz, Ainhoa Hernando, Rubio, Paula Garcia, Ledesma, Alvaro Goyoaga, Alvarez, Esteban, Poch, David, Cucchiari, José Broseta, Monzo, Beatriz Escamilla, Cabrera, Aurelio Pastor Rodríguez, Hernández, María Sagrario García, Rebollo, Juana Margarita Rufino, Hernández, Alejandra Yugueros, González, Juan Carlos, Alonso, Amparo Martínez, Más, Manuel, Calvé, Marina Garces, Cardona, Vanesa Canto, Balaguer, José Ignacio Minguela, Pesquera, Eva Cotilla, de la Rosa, David Rodríguez, Santarelli, Alba Santos, Garcia, Antonio Cabezas, Martin-Caro, Inmaculada Martinez, Santamaria, Michal, Cervienka, Ana María Urraca, de la Pisa, Lidia Sendino, Monzon, Karina Ampuero, Anachuri, Esther Hernández, Garcia, Victoria Oviedo, Gomez, Raquel Santana, Estupiñán, Francisco Valga, Amado, Patricia Pérez, Borges, Marta Durán, Beloso, Fernanda Arroyo, Alonso, Noemí Pérez, Felpete, Ana Meizoso, Ameneiro, Mónica Cunha, Mera, Beatriz Gil, Casares, Sofía Zarraga, Larrondo, Naroa Maruki, Kareaga, Ainhoa Inza San Salvador, Del Valle, Ana Rosa Muñoz, García, Blanca Villacorta, Linaza, Nuria, Del Toro Espinosa, Paola Estupiñan, Perico, José Manuel Sánchez, Oliva, Joaquín, Manrique, Itziar, Castaño, Carolina, Purroi, Nerea, Gómez, Cristina, Mansilla, Ane, Utzurrum, Manuel Ramírez, de Arellano Serna, Luis Guirado, Perich, María Muñiz, Rincón, Jesús Grande, Villoria, and Alfonso Pobes Martínez, De Salinas

Subjects
kidney transplant, Transplantation, Nephrology, SARS-CoV-2, CKD, COVID-19, dialysis, vaccines
Abstract

Background There is scarce evidence on the fourth dose of severe acute respiratory syndrome coronavirus 2 vaccines in chronic kidney disease (CKD) patients. We evaluated the humoral response and effectivity of the fourth dose in the CKD spectrum: non-dialysis CKD (ND-CKD), haemodialysis (HD), peritoneal dialysis (PD) and kidney transplant (KT) recipients. Methods This is a prespecified analysis of the prospective, observational, multicentric SENCOVAC study. In patients with CKD who had received a complete initial vaccination and one or two boosters and had anti-Spike antibody determinations 6 and 12 months after the initial vaccination, we analysed factors associated with persistent negative humoral response and higher anti-Spike antibody titres as well as the efficacy of vaccination on coronavirus disease 2019 (COVID-19) severity. Results Of 2186 patients (18% KT, 8% PD, 69% HD and 5% ND-CKD), 30% had received a fourth dose. The fourth dose increased anti-Spike antibody titres in HD (P = .001) and ND-CKD (P = .014) patients and seroconverted 72% of previously negative patients. Higher anti-Spike antibody titres at 12 months were independently associated with repeated exposure to antigen (fourth dose, previous breakthrough infections), previous anti-Spike antibody titres and not being a KT recipient. Breakthrough COVID-19 was registered in 137 (6%) patients, 5% of whom required admission. Admitted patients had prior titres Conclusions A fourth vaccine dose increased anti-Spike antibody titres or seroconverted many CKD patients, but those with the highest need for a vaccine booster (i.e. those with lower pre-booster antibody titres or KT recipients) derived the least benefit in terms of antibody titres. Admission for breakthrough COVID-19 was associated with low anti-Spike antibody titres.

Published
2023

4. Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma

Author

Laura Juaneda-Magdalena, Alfredo Repáraz-Andrade, Carmen Fachal, Mónica Muñoz-Martín, José-María Lamas-Barreiro, Pilar San Miguel-Fraile, José-Antonio Ortiz-Rey, Susana Teijeira, Sheila Almuster-Domínguez, and Carolina Gómez-de María

Subjects
Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Biology, Kidney, Pathology and Forensic Medicine, Diagnosis, Differential, 03 medical and health sciences, Cytokeratin, 0302 clinical medicine, Tubulopathy, Predictive Value of Tests, Renal cell carcinoma, medicine, Humans, Nuclear atypia, Diagnostic Errors, Carcinoma, Renal Cell, Molecular Biology, Aged, Aged, 80 and over, Comparative Genomic Hybridization, Cadherin, Cell Biology, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Kidney Neoplasms, Microscopy, Electron, Clear cell renal cell carcinoma, Phenotype, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Biomarkers, Clear cell
Abstract

Clear cytoplasm is a major characteristic feature of most malignant renal neoplasms. Benign clear cells in the renal parenchyma, usually histiocytes, can occasionally be found, but they are infrequently of an epithelial nature. We report histological, immunohistochemical, ultrastructural, and cytogenomic features of clear epithelial cell clusters incidentally found in four kidney specimens. Multiple microscopic clear cell clusters were present in the cortex, often in subcapsular location. They were composed of large epithelial cells with strikingly clear cytoplasm, without nuclear atypia, arranged in solid nests, and some tubules with narrow lumina. Immunohistochemically, they were positive for AE1AE3, PAX 8, EMA, kidney-specific cadherin, cytokeratin 7, E cadherin, and CD117, with focal immunoreactivity for CD10. Carbonic anhydrase IX, vimentin, and markers related to apoptosis and proliferation were negative. Ultrastructurally, the cytoplasms were enlarged and poor in organelles, showing ballooning degeneration. Array comparative genomic hybridization showed no chromosomal gains or losses. Clear cell clusters constitute a rare finding in the kidney and must be differentiated from benign lesions (ectopic adrenal tissue, osmotic tubulopathy, histiocytic clusters, renal adenomas) and renal cell carcinomas. Clear cell clusters appear to be generated from "endocrine-type" atrophic tubules whose cells are enlarged due to intracellular oedema. Immunohistochemistry shows a distal nephron phenotype with a limited expression of a proximal marker, CD10. Coexisting chronic renal disease or ischemic conditions seem to be related to the development of clear cell clusters. Pathological, ultrastructural, and cytogenomic features do not support a preneoplastic nature of this lesion, at least in the cases studied here.

Published
2021

5. Supresión de angiotensina II en la infección por el virus SARS-CoV-2: una propuesta terapéutica

Author

Mario Alonso-Suárez, Jesus Angel Saavedra-Alonso, José María Lamas-Barreiro, and Jorge Julián Fernández-Martín

Subjects
2019-20 coronavirus outbreak, biology, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), biology.organism_classification, medicine.disease_cause, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, Virology, Nephrology, Hypertension complications, Pandemic, Angiotensin-converting enzyme 2, Medicine, business, Betacoronavirus, Coronavirus
Published
2020
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6. [Angiotensin II suppression in SARS-CoV-2 infection: a therapeutic approach]

Author

Jorge Julián Fernández-Martín, José María Lamas-Barreiro, Jesus Angel Saavedra-Alonso, and Mario Alonso-Suárez

Subjects
2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Angiotensin-Converting Enzyme Inhibitors, Peptidyl-Dipeptidase A, lcsh:RC870-923, Losartan, Article, Diabetes Complications, Therapeutic approach, Betacoronavirus, Mice, Lisinopril, medicine, Animals, Humans, Lung, Pandemics, biology, business.industry, SARS-CoV-2, COVID-19, Virus Internalization, lcsh:Diseases of the genitourinary system. Urology, biology.organism_classification, Virology, Angiotensin II, Rats, Nephrology, Angiotensin-converting enzyme 2, Hypertension, Angiotensin-Converting Enzyme 2, business, Coronavirus Infections, medicine.drug
Published
2020

7. 002 Importancia del potasio corporal total estimado por bioimpedancia (PCT-BIA) en pacientes prevalentes en diálisis peritoneal (DP)

Author

Guillermina Barril-Cuadrado, Mario Alonso, Francisco Coronel-Díaz, Rafael Selgas-Gutiérrez, Jesus Angel Saavedra-Alonso, José María Lamas-Barreiro, Secundino Cigarran-Guldrís, and Gerardo García-Trio

Subjects
Transplantation, Urology
Abstract

El conocimiento de la homeostasis del K + es de vital importancia en los pacientes en HD. El K + serico constituye el 0,5% del total corporal y el 95 % restante es el ion intracelular dominante. El PCT disminuye con la edad. El PCT en la actualidad puede ser estimado mediante BIA, de forma habitual. El objetivo de este estudio transversal es la evaluacion del PCT-BIA en los pacientes en DP comparandolo con una poblacion control sana. Se incluyo a 128 pacientes estables en DP (el 38,3% mujeres, el 24,4 % diabeticos; edad, 55,72 ± 16,4 anos; peso, 70,6 ± 13 kg; talla, 164,2 ± 10,3 cm; superficie corporal, 1,78 ± 0,2 m 2 ; IMC, 26,2 ± 4,4) y se los comparo con 1.000 voluntarios sanos, ningun diabetico (el 52 % mujeres; edad, 51,73 ± 13 [intervalo, 18-93] anos; peso, 70,7 ± 14 kg; talla, 167 ± 9 cm; superficie corporal, 1,8 ± 0,2 m 2 ; IMC, 24,9 ± 4,2). Se realizo BIA con el autoanalizador BIA 101 (Akern, Florencia, Italia) a 50 kHz y 0,8 μA en posicion supina tras 10 min de reposo y con el peritoneo vacio en el caso de los pacientes en DP. Se analizaron los parametros obtenidos, entre los que se incluye la masa magra (MM) en kg. El PTC se calculo en milimoles segun formula de More (MC / 0,008333) y evaluado con la altura, el peso y la MM. La masa celular (MC) fue corregida segun Dittmar et al (15,166 + 2,156 × talla 2 / xcp50 + 2,849 × sexo (0 mujer, 1 varon) −0,081 × peso). Los datos se expresan como media ± desviacion estandar. Se utilizo la prueba de la χ 2 para las variables no parametricas, y para las parametricas se utilizaron la correlacion bivariable, la prueba de la t de Student y ANOVA segun fuera apropiado. Se considero significacion estadistica un valor de p 25% en varones y > 35% en mujeres, evidencio que los varones y las mujeres obesos tienen significativamente menos PTC y PTC/peso que los no obesos. No hubo diferencias en PTC/ FFM y PTC/altura. En el estado de hidratacion se evidencio una correlacion entre el indice de hidratacion (ICW/ECW) y PTC (r = 0,662; p Concluimos que los menores GEB, PTC, MC y PTC/altura de pacientes en DP (en especial las mujeres) reflejan un deterioro nutricional. El descenso de PTC se asocia a un aumento del ECW, lo que indica una expansion de volumen con reduccion de la masa celular. La obesidad evidencia mayor deplecion del PTC. PTC-BIA constituye un nuevo marcador nutricional de utilidad en la clinica diaria.

Published
2007

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