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1. High-Spectral Resolution Dark Holes: Concept, Results, and Promise

Author

Thompson, William, Johnson, Adam B., Marois, Christian, Lardière, Olivier, Grandmont, Frédéric, Hardy, Tim, Caputa, Kris, Bradley, Colin, and Singh, Garima

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Next generation high contrast imaging instruments face a challenging trade off: they will be required to deliver data with high spectral resolution at a relatively fast cadence (minutes) and across a wide field of view (arcseconds). For instruments that employ focal plane wavefront sensing and therefore require super-Nyquist sampling, these requirements cannot simultaneously be met with a traditional lenslet integral field spectrograph (IFU). For the SPIDERS pathfinder instrument, we are demonstrating an imaging Fourier transform spectrograph (IFTS) that offers a different set of tradeoffs than a lenslet IFU, delivering up to R20,000 spectral resolution across a dark hole. We present preliminary results from the SPIDERS IFTS including a chromaticity analysis of its dark hole and demonstrate a spectral differential imaging (SDI) improvement of up to 40 $\times$, and a first application of spectro-coherent differential imaging, combining both coherent differential imaging (CDI) and SDI., Comment: Submitted to the proceedings of adaptive optics for extremely large telescopes 7

Published
2023

4. A SmallSat mission study for STARLITE: superluminous tomographic atmospheric reconstruction with laser-beacons for imaging terrestrial exoplanets

Author

Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Johnson, Adam B., Padres, Ashley, Hughes, Ryan, Buonagura, Carmine, Chapman, Zane, Kubas, Alexia, Hegelein, Veronica, Mishra, Ishan, Smith, Adler, Tahsin, Abu Taqui Md, Parashar, Akshiti, Bendimerad, Rafid, Chen, Deemo, Lu, Qizhi, Kounios, Asterios Aidan, Desilva, Devin, Padres, Verena, Lloyd, Jamie, Savransky, Dmitry, Umansky-Castro, Joshua, van Paridon, Andrew, and Petro, Elaine

Published
2024
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11. The First Hybrid International Educational Comprehensive Cleft Care Workshop

Author

Kantar, Rami S., Esenlik, Elçin, Al Abyad, Omar S., Melhem, Antonio, Younan, Robert A., Haddad, Mario, Keith, Kristen, Kassam, Serena, Annan, Beyhan, Vijayakumar, Charanya, Picard, Arnaud, Padwa, Bonnie L., Sommerlad, Brian, Raposo-Amaral, Cassio Eduardo, Forrest, Christopher R., Gillett, David A., Steinbacher, Derek M., Runyan, Christopher M., Tanikawa, Daniela Y. S., Chong, David K., Fisher, David M., Mark, Hans, Canter, Halil Ibrahim, Losee, Joseph E., Patel, Krishna G., Hartzell, Larry D., Johnson, Adam B., Collares, Marcus Vinícius Martins, Alonso, Nivaldo, Chen, Philip Kuo-Ting, Tse, Raymond, Mann, Robert J., Prada-Madrid, Jose Rolando, Kobayashi, Shinji, Hussain, Syed Altaf, Kummer, Ann, Sell, Debbie A., Pereira, Valerie J., Mabry, Kelly, Gonsoulin, Courtney K., Persson, Martin, Davies, Gareth, Sethna, Navil F., Munoz-Pareja, Jennifer C., Kuijpers-Jagtman, Anne Marie, Grayson, Barry H., Grollemund, Bruno, Garib, Daniela G., Meazzini, Maria Costanza, Kharbanda, Om P., Santiago, Pedro E., Nalabothu, Prasad, Batra, Puneet, Stieber, Erin, Prasad, Dushyant, Brewster, Hugh, Ayala, Ruben, Erbay, Elif, Akcam, M. Okan, Don Griot, J. Peter W., Vyas, Raj M., Flores, Roberto L, Breugem, Corstiaan C., and Hamdan, Usama S.

Abstract

Objective Describe the first hybrid global simulation-based comprehensive cleft care workshop, evaluate impact on participants, and compare experiences based on in-person versus virtual attendance.Design Cross-sectional survey-based evaluation.Setting International comprehensive cleft care workshop.Participants Total of 489 participants.Interventions Three-day simulation-based hybrid comprehensive cleft care workshop.Main Outcome Measures Participant demographic data, perceived barriers and interventions needed for global comprehensive cleft care delivery, participant workshop satisfaction, and perceived short-term impact on practice stratified by in-person versus virtual attendance.Results The workshop included 489 participants from 5 continents. The response rate was 39.9%. Participants perceived financial factors (30.3%) the most significant barrier and improvement in training (39.8%) as the most important intervention to overcome barriers facing cleft care delivery in low to middle-income countries. All participants reported a high level of satisfaction with the workshop and a strong positive perceived short-term impact on their practice. Importantly, while this was true for both in-person and virtual attendees, in-person attendees reported a significantly higher satisfaction with the workshop (28.63 ± 3.08 vs 27.63 ± 3.93; P= .04) and perceived impact on their clinical practice (22.37 ± 3.42 vs 21.02 ± 3.45 P= .01).Conclusion Hybrid simulation-based educational comprehensive cleft care workshops are overall well received by participants and have a positive perceived impact on their clinical practices. In-person attendance is associated with significantly higher satisfaction and perceived impact on practice. Considering that financial and health constraints may limit live meeting attendance, future efforts will focus on making in-person and virtual attendance more comparable.

Published
2023
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15. Deployment of focal plane WFS technologies on 8-m telescopes: from the Subaru SPIDERS pathfinder, to the facility-class GPI 2.0 CAL2 system

Author

Marois, Christian, primary, Lardière, Olivier, additional, Thompson, William R., additional, Singh, Garima, additional, Johnson, Adam B., additional, Hardy, Tim, additional, Fitzsimmons, Joeleff, additional, Gerard, Benjamin L., additional, Sivanandam, Suresh, additional, Thibault, Simon, additional, Savransky, Dmitry, additional, Bradley, Colin, additional, Jensen-Clem, Rebecca M., additional, Demers, Mathieu, additional, Fu, Qiang, additional, Heidrich, Wolfgang, additional, and N'Diaye, Mamadou, additional

Published
2022
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17. The First Hybrid International Educational Comprehensive Cleft Care Workshop

Author

Kantar, Rami S., primary, Esenlik, Elçin, additional, Al Abyad, Omar S., additional, Melhem, Antonio, additional, Younan, Robert A., additional, Haddad, Mario, additional, Keith, Kristen, additional, Kassam, Serena, additional, Annan, Beyhan, additional, Vijayakumar, Charanya, additional, Picard, Arnaud, additional, Padwa, Bonnie L., additional, Sommerlad, Brian, additional, Raposo-Amaral, Cassio Eduardo, additional, Forrest, Christopher R., additional, Gillett, David A., additional, Steinbacher, Derek M., additional, Runyan, Christopher M., additional, Tanikawa, Daniela Y. S., additional, Chong, David K., additional, Fisher, David M., additional, Mark, Hans, additional, Canter, Halil Ibrahim, additional, Losee, Joseph E., additional, Patel, Krishna G., additional, Hartzell, Larry D., additional, Johnson, Adam B., additional, Collares, Marcus Vinícius Martins, additional, Alonso, Nivaldo, additional, Chen, Philip Kuo-Ting, additional, Tse, Raymond, additional, Mann, Robert J., additional, Prada-Madrid, Jose Rolando, additional, Kobayashi, Shinji, additional, Hussain, Syed Altaf, additional, Kummer, Ann, additional, Sell, Debbie A., additional, Pereira, Valerie J., additional, Mabry, Kelly, additional, Gonsoulin, Courtney K., additional, Persson, Martin, additional, Davies, Gareth, additional, Sethna, Navil F., additional, Munoz-Pareja, Jennifer C., additional, Kuijpers-Jagtman, Anne Marie, additional, Grayson, Barry H., additional, Grollemund, Bruno, additional, Garib, Daniela G., additional, Meazzini, Maria Costanza, additional, Kharbanda, Om P., additional, Santiago, Pedro E., additional, Nalabothu, Prasad, additional, Batra, Puneet, additional, Stieber, Erin, additional, Prasad, Dushyant, additional, Brewster, Hugh, additional, Ayala, Ruben, additional, Erbay, Elif, additional, Akcam, M. Okan, additional, Don Griot, J. Peter W., additional, Vyas, Raj M., additional, Flores, Roberto L, additional, Breugem, Corstiaan C., additional, and Hamdan, Usama S., additional

Published
2022
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26. CAL2: project update of the NRC Canada facility-class focal plane wavefront sensor for the Gemini Planet Imager 2 upgrade

Author

Jackson, Kathryn J., Schmidt, Dirk, Vernet, Elise, Marois, Christian, Lardière, Olivier, Fitzsimmons, Joeleff, Demers, Mathieu, Johnson, Adam B., Dutt, Saugata, Nkwari, Patrick, Gerard, Benjamin, Dunn, Jennifer, Li, Duan, Fu, Qiang, Brousseau, Denis, Sivanandam, Suresh, Thompson, William, Mann, Christopher, Singh, Garima, Boucher, Marc-André, Hardy, Tim, Caputa, Krzysztof, Thibault, Simon, Savransky, Dmitry, Heidrich, Wolfgang, van Kooten, Maaike, Véran, Jean-Pierre, Jensen-Clem, Rebecca, Gamroth, Darryl, Bradley, Colin, Rawat, Sanjana, Galvan, Öykü S., Herriot, Glen, and Landry, Jean-Thomas

Published
2024
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27. Detection of Respiratory Pathogens Does Not Predict Risks After Outpatient Adenotonsillectomy

Author

Vickers, Donald M., primary, Reddy, Arundathi, additional, Akmyradov, Chary, additional, Brown, Kesley M., additional, Boyanton, Bobby L., additional, Wright, Heather D., additional, Taylor, Jay A., additional, Childress, Sherry H., additional, Hartzell, Larry D., additional, Johnson, Adam B., additional, Key, James M., additional, Nolder, Abby R., additional, Richter, Gresham T., additional, Wineland, Andre’ M., additional, and Strub, Graham M., additional

Published
2020
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31. Detection of Respiratory Pathogens Does Not Predict Risks After Outpatient Adenotonsillectomy.

Author

Vickers, Donald M., Reddy, Arundathi, Akmyradov, Chary, Brown, Kesley M., Boyanton, Bobby L., Wright, Heather D., Taylor, Jay A., Childress, Sherry H., Hartzell, Larry D., Johnson, Adam B., Key, James M., Nolder, Abby R., Richter, Gresham T., Wineland, Andre' M., and Strub, Graham M.

Abstract

Objectives/Hypothesis: To determine whether the presence of detectable upper respiratory infections (URIs) at the time of adenoidectomy/adenotonsillectomy is associated with increased morbidity, complications, and unexpected admissions. Study Design: Prospective double‐blinded cohort. Methods: In this prospective cohort study, nasopharyngeal swabs were obtained intraoperatively from 164 pediatric patients undergoing outpatient adenoidectomy/tonsillectomy with or without pressure equalization tubes (PETs) and were analyzed with PCR for the presence of 22 known URIs, including SARS‐CoV‐2. Surgeons and families were blinded to the results. At the conclusion of the study, rates of detectable infection were determined and intraoperative and postoperative events (unexpected admissions, length of PACU stay, rates of laryngospasm/bronchospasm, oxygen desaturation, bradycardia, and postoperative presentation to an emergency department) were compared between infected and uninfected patients. Results: Of the 164 patients (50% male, 50% female, ages 8 mo‐18 y), 136 patients (82.9%) tested positive for one or more URI at the time of surgery. Forty one patients (25.0%) tested positive for three or more URIs concurrently, and 11 (6.7%) tested positive for five or more URIs concurrently. There were no significant differences in admission rates, length of PACU stay, rates of laryngospasm/bronchospasm, oxygen desaturation, bradycardia, or postoperative presentation to an emergency department between positive and negative patients. No patients tested positive for SARS‐CoV‐2. Conclusions: A recent positive URI test does not confer any additional intraoperative or postoperative risk in the setting of outpatient adenoidectomy/tonsillectomy in healthy patients. There is no utility in preoperative URI testing, and delaying surgery due to a recent positive URI test is not warranted in this population. Level of Evidence: 3 Laryngoscope, 131:E2074–E2079, 2021 [ABSTRACT FROM AUTHOR]

Published
2021
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35. Translation fidelity coevolves with longevity

Author

Ke, Zhonghe, primary, Mallik, Pramit, additional, Johnson, Adam B., additional, Luna, Facundo, additional, Nevo, Eviatar, additional, Zhang, Zhengdong D., additional, Gladyshev, Vadim N., additional, Seluanov, Andrei, additional, and Gorbunova, Vera, additional

Published
2017
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40. Eosinophilic esophagitis in children under the age of 5 years: Clinical characteristics.

Author

Sun, Ravi W., Bonilla‐Velez, Juliana, Pesek, Robert D., Johnson, Adam B., Cleves, Mario A., and Richter, Gresham T.

Abstract

Objectives/Hypothesis: To delineate clinical characteristics and treatment outcomes of eosinophilic esophagitis (EoE) in the youngest of children. Study Design: Retrospective chart review. Methods: A 7‐year retrospective chart review of children with clinicopathologic diagnosis of EoE was performed with specific analysis of patients under 5 years old. EoE was defined as the presence of symptoms of esophageal dysfunction with pathologically proven eosinophilic inflammation (≥15 eosinophils per high‐power field [EOS/HPF]) unresponsive to reflux therapy. Patient parameters and clinical results were systematically reviewed. Results: Of 558 children diagnosed with EoE, 127 (22.8%) were younger than 5 years old (mean age 2.5 years). This subgroup presented with reflux symptoms (90.1%), vomiting (86.2%), diarrhea (55.3%), liquid dysphagia (52.0%), and constipation (50.0%), whereas food impaction (1.6%) was rare. Liquid dysphagia was present at all ages but significantly more common in younger children (P = .0101). The most common food and environmental allergens were egg whites (39.7%), cow's milk (36.5%), peanuts (34.9%), animal dander (15.1%), and weed pollen (11.1%). Patients were managed with antireflux medication (100%), elimination diet (83.5%), and steroid medication (68.5%). After treatment, 86% of parents reported symptom improvement. Mean reduction of EOS in pos‐treatment biopsy was 33.5 EOS/HPF (P < .0001), and 67 patients showed histologic resolution of EoE (56.8%, P < .0001). Conclusions: Approximately one‐quarter of children with EoE present under 5 years of age with multiple esophageal symptoms, comorbidities, and allergen‐sensitization profiles. These patients demonstrate substantial clinicohistologic improvement following therapy. Level of Evidence: 4. Laryngoscope, 128:798–805, 2018 [ABSTRACT FROM AUTHOR]

Published
2018
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44. llyanassa Notch signaling implicated in dynamic signaling between all three germ layers.

Author

GHARBIAH, MAEY, AYAKI NAKAMOTO, JOHNSON, ADAM B., LAMBERT, J. DAVID, and NAGY, LISA M.

Subjects
CELLULAR signal transduction, SNAILS, CELL differentiation, DEVELOPMENTAL biology, SMALL interfering RNA, ENDODERM
Abstract

Two cells (3D and 4d) in the mud snail llyanassa obsoleta function to induce proper cell fate. In this study, we provide support for the hypothesis that Notch signaling in llyanassa obsoleta functions in inductive signaling at multiple developmental stages.The expression patterns of Notch, Delta and Suppressor of Hairless (SuH) are consistent with a function for Notch signaling in endoderm formation, the function of 3D/4d and the sublineages of 4d. Veligers treated with DAPT show a range of defects that include a loss of endodermal structures, and varying degrees of loss of targets of 4d inductive signaling. Veligers that result from injection of llyanassa Delta siRNAi in general mimic the defects observed in the DAPT treated larvae.The most severe DAPT phenotypes mimic early ablations of 4d. However, the early specification of 4d itself appears normal and MAPK activation in both 3D/4d and the micromeres, which are known to activate MAPK as a result of 3D/4d induction, are normal in DAPT treated larvae.Treating larvae at successively later timepoints with DAPT suggests that Notch/Delta signaling is not only required during early 4d inductive signaling, but during subsequent stages of cell fate determination as well. Based on our results, combined with previous reports implicating the endoderm in maintaining induced fate specification in llyanassa, we propose a speculative model that Notch signaling is required to specify endoderm fates and 4d sublineages, as well as to maintain cell fates induced by 4d. [ABSTRACT FROM AUTHOR]

Published
2014
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47. Gentle ND:YAG Laser Therapy in the Treatment of Cutaneous Venous Malformations.

Author

Spradley TP, Johnson AB, Wright HD, Kincannon JM, and Richter GT

Subjects
Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Male, Photography, Prospective Studies, Retrospective Studies, Single-Blind Method, Treatment Outcome, Veins surgery, Young Adult, Dermatologic Surgical Procedures methods, Lasers, Solid-State therapeutic use, Skin blood supply, Vascular Malformations surgery, Veins abnormalities
Abstract

Background: Venous malformations (VMs) are congenital vascular malformations that grow progressively and never resolve on their own. Cutaneous VMs are difficult to treat due to risk of injury and deformation. The purpose of this study was to examine the safety and efficacy of a modified neodymium-doped yttrium aluminum garnet laser (Gentle YAG) in the management of cutaneous VMs. Methods: Retrospective chart review of patients undergoing Gentle YAG therapy for cutaneous VMs and a blind prospective evaluation of photographs, performed by 10 reviewers, before and after treatment for growth, stability, improvement, or resolution of VMs. Results: Forty-five patients (18 males and 27 females) who underwent Gentle YAG therapy for a cutaneous VM were identified. Based on photographic review, Gentle YAG therapy elicited improvement in the appearance of VMs in 72% of the patients, χ 2 (1, N  = 45) = 25.94, p  < 0.0001, with reviewers noting complete resolution in 8.2%, significant improvement in 34.5%, some improvement in 29.3%, and no growth or improvement in 20.9% of patients. Growth of the VM was noted in 7.3% of patients. Three (6.7%) patients reported complications from the treatment, which included infection, bleeding, blister, and color change. Four patients (8.9%) reported pretreatment pain, which resolved in three (75.0%) after treatment. Conclusions: Gentle YAG therapy can provide safe and effective treatment for cutaneous VMs and should be considered in the multimodal management of VMs.

Published
2021
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48. Laser Treatment Of Pigmented Lesions

Author

Gaffey MM and Johnson AB

Abstract

The acronym LASER stands for Light Amplification by Stimulated Emission of Radiation. At their core, lasers use electromagnetic radiation to excite electrons, causing the electrons to emit photons during the return from their excited state back to a resting state. The energy produced in the form of light travels along a wavelength. Wavelengths that fall within the visible spectrum lie between 400 and 700 nanometers, but various lasers exist which travel on wavelengths of the electromagnetic spectrum that exist outside of the visible spectrum.   Since debuting in a medical capacity in the 1960s, medical lasers have become increasingly adaptable to various fields of medicine. The ability of lasers to target specific colors through the use of specific laser wavelengths has assisted in placing lasers at the forefront in the treatment of pigmented lesions, such as vascular lesions of the skin and mucosa, unwanted tattoos, and pigmented nevi. It is critical to have a working understanding of laser function, terminology, and safety before treating pigmented lesions. Of equal importance is an understanding of these pigmented lesions, so that the appropriate laser can be selected for use. This article strives to provide a foundation for such recognition.[1], (Copyright © 2021, StatPearls Publishing LLC.)

Published
2021

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