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Herein, we present a proof-of-concept 3D (multilevel) passive microfluidic device for point-of-care applications including electrochemical biosensors. Multiphase flow (air-water interface) within multilevel microchannels has been evaluated using 3D numerical simulations. The design was based on a pre-programmed sequence of fluids (biofluids and electrolytes) on the surface of a biosensor using trigger valves and microchannel resistances. Flow was driven uniquely by the surface tension and the capillary force triggered by the introduction of the sample without any external microfluidic equipment

Liquid biopsy (LB) represents an important tool for modern oncology that enables increasingly safe, personalized, and robust cancer diagnosis and treatment. State-of-the-art LB systems require the amplification of the DNA in the blood samples, a cost and time-consuming process. Using low light level photosensors and arrival timing information, we aim with PHIL to avoid the amplification stage which would be a breakthrough in the field of molecular diagnostic in oncology. In this article, we summarize our achievements during the project and our future vision.

Liquid biopsy (LB) represents an important tool for modern oncology that enables increasingly safe, personalized, and robust cancer diagnosis and treatment. State-of-the-art LB systems require the amplification of the DNA in the blood samples, a cost and time-consuming process. Using low light level photosensors and arrival timing information, we aim with PHIL to avoid the amplification stage which would be a breakthrough in the field of molecular diagnostic in oncology. In this article, we summarize our achievements during the project and our future vision.