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High throughput determination log Po/w/pKa/log Do/w of drugs by combination of UHPLC and CE methods
- Source :
- ADMET and DMPK, Vol 2, Iss 2, Pp 98-106 (2014)
- Publication Year :
- 2014
- Publisher :
- International Association of Physical Chemists (IAPC), 2014.
-
Abstract
- In 1997 Valkó et al. developed a generic fast gradient HPLC method, based on the calculation of the chromatographic hydrophobicity index (CHI) from the gradient retention times, in order to measure lipophilicity. We have enhanced the correlations between CHI and log Po/w and adapted the rapid gradient HPLC method to UHPLC obtaining excellent resolution and repeatability in a short analysis time (
- Subjects :
- Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 18487718
- Volume :
- 2
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- ADMET and DMPK
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7643fd29186d4cee94fd44ace1acb5aa
- Document Type :
- article
- Full Text :
- https://doi.org/10.5599/admet.2.2.44