4,891 results on '"Jinks A"'
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2. Opportunities to Enhance Diagnostic Testing and Antimicrobial Stewardship: A Qualitative Multinational Survey of Healthcare Professionals
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Jinks, Timothy, Subramaniam, Sumithra, Bassetti, Matteo, Gales, Ana C., Kullar, Ravina, Metersky, Mark L., Poojary, Aruna, Seifert, Harald, Warrier, Anup, Flayhart, Diane, Kelly, Timothy, Yu, Kalvin, Altevogt, Bruce M., Townsend, Andy, Marsh, Charlotte, and Willis, Clare
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- 2024
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3. Evaluating qualitative data analysis workshops from the perspective of public contributors
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Moult, Alice, McGrath, Carmel, Lippiett, Kate, Coope, Caroline, Turner, Andrew, Chillcott, Simon, Parton, Linda, Holloway, Pam, Dace, Sally, Gibson, Andy, Jinks, Clare, Paskins, Zoe, Portillo, Mari Carmen, Mann, Cindy, and Dziedzic, Krysia
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- 2024
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4. A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems
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Rani, Manju, Chawla, Neha, Wadhwa, Nitya, Mathur, Roli, Jinks, Timothy, Das, Priyanka, and Rijal, Suman
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- 2024
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5. Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study
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Bullock, Laurna, Manning, Fay, Hawarden, Ashley, Fleming, Jane, Leyland, Sarah, Clark, Emma M., Thomas, Simon, Gidlow, Christopher, Iglesias-Urrutia, Cynthia P., Protheroe, Joanne, Lefroy, Janet, Ryan, Sarah, O’Neill, Terence W., Mallen, Christian, Jinks, Clare, and Paskins, Zoe
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- 2024
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6. Variation in UK fracture liaison service consultation conduct and content before and during the COVID pandemic: results from the iFraP-D UK survey
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Bullock, Laurna, Abdelmagid, Sittana, Fleming, Jane, Leyland, Sarah, Clark, Emma M., Gidlow, Christopher, Iglesias-Urrutia, Cynthia P., O’Neill, Terence W., Mallen, Christian, Jinks, Clare, and Paskins, Zoe
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- 2024
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7. A transformative solution to build effective, transparent, and resilient 'fit-for-purpose' national health research ethics systems
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Manju Rani, Neha Chawla, Nitya Wadhwa, Roli Mathur, Timothy Jinks, Priyanka Das, and Suman Rijal
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Research ethics ,Ethical review/standards ,Ethics committees ,Research participants ,Ethics review systems ,Harmonization of research ethics review ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC.
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- 2024
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8. Evaluating qualitative data analysis workshops from the perspective of public contributors
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Alice Moult, Carmel McGrath, Kate Lippiett, Caroline Coope, Andrew Turner, Simon Chillcott, Linda Parton, Pam Holloway, Sally Dace, Andy Gibson, Clare Jinks, Zoe Paskins, Mari Carmen Portillo, Cindy Mann, and Krysia Dziedzic
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Patient and public involvement ,Evaluation ,Qualitative research ,Cube ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Background The aim of this project is to evaluate public contributors’ experiences of their involvement in qualitative data analysis workshops during an on-going research project titled ‘Personalised Primary care for Patients with Multiple long-term conditions’. Methods Four qualitative data analysis workshops were designed and conducted between August and December 2023. We used the Cube evaluation framework (henceforth referred to as the Cube) to evaluate the workshops. The Cube suggests four domains for successful PPI (voice, agenda, change, contribute).Within Workshops One, Two and Three public contributors had to login to an account to access the Cube; this was modified in Workshop Four following feedback from public contributors. Findings Across the four workshops the Cube was completed 11 times. Across all four workshops, public contributors thought that their voice was heard, that there were diverse ways to contribute and that they led the agenda. Public contributors thought that researchers responded to their questions and issues, when necessary. Conclusion This evaluation has shown that public contributors can gain new skills and lead qualitative data analysis discussions.
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- 2024
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9. Reviews for multimorbidity risk in people with inflammatory conditions: a qualitative study
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Lauren Gray, Laurna Bullock, Carolyn A Chew-Graham, Clare Jinks, Zoe Paskins, and Samantha Hider
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review consultations ,multimorbidity ,inflammatory arthritis ,arthritis, rheumatoid ,qualitative research ,Medicine (General) ,R5-920 - Abstract
Background: People with inflammatory rheumatological conditions (IRCs) are at high risk of developing other conditions including cardiovascular disease (CVD) and mood disorders. Aim: To explore perspectives of people with IRCs and healthcare practitioners (HCPs) on the content and delivery of a review consultation aimed at identification and management of multiple long-term conditions (mLTCs). Design & setting: Semi-structured interviews and focus groups with people with IRCs and HCPs in primary and secondary care. Method: People with IRCs participated in individual semi-structured interviews by telephone or online platform. HCPs (including primary and secondary care clinicians) participated in online focus groups. Data were transcribed verbatim and analysed using inductive thematic analysis. Results: Fifteen people with IRCs were interviewed; three focus groups with HCPs were conducted. The following two main themes were identified: reflecting on the value of review consultations; and what would a new review look like? Overall, people with IRCs and HCPs reflected that access to reviews is inequitable, leading to duplication of reviews and fragmentation in care. People with IRCs, at times, had difficulty conceptualising reviews, especially when discussing their future risk of conditions. People suggested that preparation before the healthcare review could align patient and HCP agendas as part of a flexible and person-centred discussion. Conclusion: Any review introduced for people with IRCs must move beyond a ‘tick-box’ exercise. To gain maximum value from a review, preparation from both patient and HCP may be required alongside a person-centred approach while ensuring they are targeted at people most likely to benefit.
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- 2024
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10. Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study
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Charlotte Woodcock, Nicola Cornwall, Lisa Dikomitis, Sarah A Harrisson, Simon White, Toby Helliwell, Roger Knaggs, Eleanor Hodgson, Tamar Pincus, Miriam Santer, Christian D Mallen, Julie Ashworth, Clare Jinks, and on behalf of the PROMPPT research team
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pharmacists ,analgesics, opioid ,chronic pain ,Medicine (General) ,R5-920 - Abstract
Background: Opioids are frequently prescribed for persistent non-cancer pain despite limited evidence of long-term effectiveness and risk of harm. Evidence-based interventions to address inappropriate opioid prescribing are lacking. Aim: To explore perspectives of people living with persistent pain to understand barriers and facilitators in reducing opioids in the context of a pharmacist-led primary care review, and identify review components and features for optimal delivery. Design & setting: A multi-method qualitative study undertaken in the primary care setting in the UK. Method: Adults with experience of persistent pain and taking opioids participated in semi-structured interviews (n = 15, 73% female) and an online discussion forum (n = 31). The Theoretical Domains Framework (TDF) provided a framework for data collection and thematic analysis, involving deductive analysis to TDF domains, inductive analysis within domains to generate sub-themes, and sub-theme comparison to form across-domain overarching themes. The behaviour change technique taxonomy (v1) and motivational behaviour change technique classification system were used to systematically map themes to behaviour change techniques to identify potential review components and delivery features. Results: Thirty-two facilitator and barrier sub-themes for patients reducing opioids were identified across 13 TDF domains. These combined into the following six overarching themes: learning to live with pain; opioid reduction expectations; assuming a medical model; pharmacist-delivered reviews; pharmacist–patient relationship; and patient engagement. Sub-themes mapped to 21 unique behaviour change techniques, yielding 17 components and five delivery features for the proposed PROMPPT review. Conclusion: This study generated theoretically informed evidence for design of a practice pharmacist-led PROMPPT review. Future research will test the feasibility and acceptability of the PROMPPT review and pharmacist training.
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- 2024
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11. A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 2; peer review: 2 approved]
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Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, and Ashley Hawarden
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Shared decision-making ,decision aid ,osteoporosis ,randomised controlled trial ,Fracture Liaison Service ,iFraP ,eng ,Medicine - Abstract
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values. We developed the improving uptake of Fracture Prevention drug treatments (iFraP) intervention comprising a computerised Decision Support Tool (DST), clinician training package and information resources, for use in UK Fracture Liaison Service consultations. Two primary objectives to determine (1) the effect of the iFraP intervention on patient-reported ease in decision-making about osteoporosis medicines, and (2) cost-effectiveness of iFraP intervention compared to usual NHS care. Secondary objectives are to determine the iFraP intervention effect on patient reported outcome and experience measures, clinical effectiveness (osteoporosis medicine adherence), and to explore intervention acceptability, mechanisms, and processes underlying observed effects, and intervention implementation. Methods The iFraP trial is a pragmatic, parallel-group, individual randomised controlled trial in patients referred to a Fracture Liaison Service, with nested mixed methods process evaluation and health economic analysis. Participants aged ≥50 years (n=380) are randomised (1:1 ratio) to one of two arms: (1) iFraP intervention (iFraP-i) or (2) comparator usual NHS care (iFraP-u) and are followed up at 2-weeks and 3-months. The primary outcome is ease of decision-making assessed 2 weeks after the consultation using the Decisional Conflict Scale (DCS). The primary objectives will be addressed by comparing the mean DCS score in each trial arm (using analysis of covariance) for patients given an osteoporosis medicine recommendation, alongside a within-trial cost-effectiveness and value of information (VoI) analysis. Process evaluation data collection includes consultation recordings, semi-structured interviews, and DST analytics. Discussion The iFraP trial will answer important questions about the effectiveness of the new ‘iFraP’ osteoporosis DST, coupled with clinician training, on SDM and informed initiation of osteoporosis medicines. Trial registration ISRCTN 10606407, 21/11/2022 https://doi.org/10.1186/ISRCTN10606407
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- 2024
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12. Out of the shadows: automatic fish detection from acoustic cameras
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Connolly, R. M., Jinks, K. I., Shand, A., Taylor, M. D., Gaston, T. F., Becker, A., and Jinks, E. L.
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- 2023
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13. Opportunities to Enhance Diagnostic Testing and Antimicrobial Stewardship: A Qualitative Multinational Survey of Healthcare Professionals
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Timothy Jinks, Sumithra Subramaniam, Matteo Bassetti, Ana C. Gales, Ravina Kullar, Mark L. Metersky, Aruna Poojary, Harald Seifert, Anup Warrier, Diane Flayhart, Timothy Kelly, Kalvin Yu, Bruce M. Altevogt, Andy Townsend, Charlotte Marsh, and Clare Willis
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Antimicrobial resistance ,Antimicrobial stewardship ,Bacteria and bacterial infections ,Diagnostic technologies ,Healthcare professional survey ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Introduction Antimicrobial resistance (AMR) is a global public health challenge. Global efforts to decrease AMR through antimicrobial stewardship (AMS) initiatives include education and optimising the use of diagnostic technologies and antibiotics. Despite this, economic and societal challenges hinder AMS efforts. The objective of this study was to obtain insights from healthcare professionals (HCPs) on current challenges and identify opportunities for optimising diagnostic test utilisation and AMS efforts. Methods Three hundred HCPs from six countries (representing varied gross national incomes per capita, healthcare system structure, and AMR rates) were surveyed between November 2022 through January 2023. A targeted literature review and expert interviews were conducted to inform survey development. Descriptive statistics were used to summarise survey responses. Results These findings suggest that the greatest challenges to diagnostic test utilisation were economic in nature; many HCPs reported that AMS initiatives were lacking investment (32.3%) and resourcing (40.3%). High resistance rates were considered the greatest barriers to appropriate antimicrobial use (52.0%). Most HCPs found local and national guidelines to be very useful (≥ 51.0%), but areas for improvement were noted. The importance of AMS initiatives was confirmed; diagnostic practices were acknowledged to have a positive impact on decreasing AMR (70.3%) and improving patient outcomes (81.0%). Conclusion AMS initiatives, including diagnostic technology utilisation, are pivotal to decreasing AMR rates. Interpretation of these survey results suggests that while HCPs consider diagnostic practices to be important in AMS efforts, several barriers to successful implementation still exist including patient/institutional costs, turnaround time of test results, resourcing, AMR burden, and education. While some barriers differ by country, these survey results highlight areas of opportunities in all countries for improved use of diagnostic technologies and broader AMS efforts, as perceived by HCPs. Greater investment, resourcing, education, and updated guidelines offer opportunities to further strengthen global AMS efforts.
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- 2024
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14. A comparison of the early growth and survival of lesser-known tree species for climate change adaptation in Britain
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Ovenden, Thomas S., Jinks, Richard L., Mason, William L., Kerr, Gary, and Reynolds, Chris
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- 2024
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15. Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials
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Holden, MA, Murphy, M., Simkins, J., Thomas, MJ, Huckfield, L., Quicke, JG, Halliday, N., Birrell, FN, Borrelli, B., Callaghan, MJ, Dziedzic, K., Felson, D., Foster, NE, Ingram, C., Jinks, C., Jowett, S., Nicholls, E., and Peat, G.
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- 2024
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16. Influences on Teacher Perceptions of Gifted Characteristics
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Jinks, Audrey
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This study examined the relationships between teacher experience and perceptions of gifted characteristics. Teachers are the primary source of student referrals for gifted placement and service; therefore, understanding the relationships between teacher perceptions and their work experience is important to understand possible barriers to gifted identification. This study identified the impact of years of teaching experience, professional training to serve gifted students, and employment setting on perceptions of gifted characteristics. Participants included 576 general education teachers serving grades kindergarten through fifth in U.S. public schools. Participants completed a survey that measured perceptions of gifted characteristics across domains outlined by Gagne's Differentiated Model of Giftedness and Talent. Data analysis determined the relationship between teacher experience and perceptions of giftedness with a small positive statistically significant correlation between increased years of teaching and perceptions of giftedness. Additionally, a small positive correlation was found between professional training in gifted education and teacher perceptions of giftedness. Finally, analysis determined that perceptions of giftedness were statistically significantly different for teachers working in Title I and non-Title I schools. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2023
17. 1H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studies
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Jinks, Maren, Davies, Emily C., Boughton, Berin A., Lodge, Samantha, and Maker, Garth L.
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- 2024
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18. Genetic screens in intestinal organoid (mini-gut) culture using CRISPR-Cas-9 system and studying the role of FBXL5 in colorectal cancer cells
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Jinks, Nicholas
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WI Digestive system - Abstract
Current in vitro research methods are often difficult to translate into successful gene(s) functional and clinical applications. Immortalised cell lines are monocellular, 2-dimensional and do not accurately encapsulate the in vivo microenvironment, while in vivo animal models are often impractical, prohibitively expensive and ethically contentious. As such, novel in vitro experimental models are required to facilitate research and improve translatability, particularly in colorectal cancer, which demonstrates great genetic and phenotypic heterogeneity. Recently, methods for the in vitro culture of three-dimensional (3D) derived "organoids" have been established, which faithfully reproduce the genetic, proteomic and pharmacological characteristics of their original tissue. Organoids present the opportunity to elucidate molecular mechanisms underlying functional genetic modelling, personalised medicine and drug discovery in vitro, thereby replacing and reducing the use of in vivo animal models. In this study, we have initially combined the CRISPR/Cas-9 genome editing system and murine intestinal/colon epithelial organoid cultures to study the functional impact of genetic knockouts of the F-box family of E3 ligases, which are poorly understood in colorectal cancer development and progression. Among the 32 F-box genes we screened, five F-box knockout murine intestinal organoid lines demonstrated differential growth pattern and morphology characteristics from healthy/normal control organoids: the fbxl5, fbxo31, fbxl18, fbxo17 and fbxl17 genes. Moreover, we selected FBXL5 (F-box/LRR-repeat protein 5) for additional functional analysis. Previous studies reported that FBXL5 plays a key role in iron homeostasis by promoting ubiquitination and degradation of the IRP2 protein and other molecules, maintaining of hematopoietic and neural stem/progenitor cell pool, hypoxia and drug response and epithelial-to-mesenchymal transition (EMT). However, the role of FBXL5 in colorectal cancer cells is less characterised. Furthermore, we generated CRISPR-Cas-9-mediated knockout DLD-1 and SW480 colorectal cancer cell lines to investigate the loss of FBXL5 in colorectal cancer function and activity. We found that FBXL5 knockout significantly reduces wound healing and colony formation efficiency, and dysregulates cell morphology, epithelial-to-mesenchymal transition activity, iron homeostasis, autophagy, hypoxic cell activity and drug response in colorectal cancer cells. In addition, toward a mechanistic approach for the characterisation of FBXL5 function and gene downstream analysis, differentially expressed genes (DEG) were identified using RNA-Seq analysis of FBXL5-knockout and parental DLD-1 colorectal cancer cells. Pathway mapping of the DEGs identified numerous novel FBXL5 roles, particularly under hypoxic conditions, including colorectal and pancreatic cancer, immune system function, spliceosome activity and carbon metabolism in cancer. However, further investigation is required to explore the significant loss of FBXL5 E3 ligase function and targeted proteins in patients with colorectal cancer. In conclusion, we have demonstrated the value and practicality of organoids as a flexible in vitro model system for functional genetic studies, representing an important tool for improving research methodology and reducing and replacing the use of in vivo models in research. We also demonstrated that FBXL5 may be a key player in colorectal cancer progression, metastasis, and relapse via influences in iron homeostasis, autophagy, hypoxic cell activity and drug response.
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- 2022
19. A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 1; peer review: 2 approved]
- Author
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Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, and Ashley Hawarden
- Subjects
Shared decision-making ,decision aid ,osteoporosis ,randomised controlled trial ,Fracture Liaison Service ,iFraP ,eng ,Medicine - Abstract
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values. We developed the improving uptake of Fracture Prevention drug treatments (iFraP) intervention comprising a computerised Decision Support Tool (DST), clinician training package and information resources, for use in UK Fracture Liaison Service consultations. Two primary objectives to determine (1) the effect of the iFraP intervention on patient-reported ease in decision-making about osteoporosis medicines, and (2) cost-effectiveness of iFraP intervention compared to usual NHS care. Secondary objectives are to determine the iFraP intervention effect on patient reported outcome and experience measures, clinical effectiveness (osteoporosis medicine adherence), and to explore intervention acceptability, mechanisms, and processes underlying observed effects, and intervention implementation. Methods The iFraP trial is a pragmatic, parallel-group, individual randomised controlled trial in patients referred to a Fracture Liaison Service, with nested mixed methods process evaluation and health economic analysis. Participants aged ≥50 years (n=380) are randomised (1:1 ratio) to one of two arms: (1) iFraP intervention (iFraP-i) or (2) comparator usual NHS care (iFraP-u) and are followed up at 2-weeks and 3-months. The primary outcome is ease of decision-making assessed 2 weeks after the consultation using the Decisional Conflict Scale (DCS). The primary objectives will be addressed by comparing the mean DCS score in each trial arm (using analysis of covariance) for patients given an osteoporosis medicine recommendation, alongside a within-trial cost-effectiveness and value of information (VoI) analysis. Process evaluation data collection includes consultation recordings, semi-structured interviews, and DST analytics. Discussion The iFraP trial will answer important questions about the effectiveness of the new ‘iFraP’ osteoporosis DST, coupled with clinician training, on SDM and informed initiation of osteoporosis medicines. Trial registration: ISRCTN 10606407, 21/11/2022 https://doi.org/10.1186/ISRCTN10606407
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- 2024
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20. Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England
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Christian Mallen, Clare Jinks, Ram Bajpai, Toby Helliwell, Sarah Lawton, Sara Muller, Zarish Hussain, and Cath Holmstrom
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Medicine - Abstract
Objectives To determine General Practice (GP) recording of carer status and the number of patients self-identifying as carers, while self-completing an automated check-in screen prior to a GP consultation.Design A descriptive cross-sectional study.Setting 11 GPs in the West Midlands, England. Recruitment commenced in September 2019 and concluded in January 2020.Participants All patients aged 10 years and over, self-completing an automated check-in screen, were invited to participate during a 3-week recruitment period.Primary and secondary outcome measures The current coding of carers at participating GPs and the number of patients identifying themselves as a carer were primary outcome measures. Secondary outcome measures included the number of responses attained from automated check-in screens as a research data collection tool and whether carers felt supported in their carer role.Results 80.3% (n=9301) of patients self-completing an automated check-in screen participated in QUantifying the identification Of carers in general practice (STATUS QUO Study) (62.6% (n=5822) female, mean age 52.9 years (10–98 years, SD=20.3)). Prior to recruitment, the clinical code used to denote a carer was identified in 2.7% (n=2739) of medical records across the participating GPs.10.1% (n=936) of participants identified themselves as a carer. They reported feeling supported with their own health and social care needs: always 19.3% (n=150), a lot of the time 13.2% (n=102), some of the time 40.8% (n=317) and never 26.7% (n=207).Conclusions Many more participants self-identified as a carer than were recorded on participating GP lists. Improvements in the recording of the population’s caring status need to be actioned, to ensure that supportive implementation strategies for carers are effectively received. Using automated check-in facilities for research continues to provide high participation rates.
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- 2024
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21. Deletions initiated by the vaccinia virus TopIB protein in yeast
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Cho, Jang Eun, Shaltz, Samantha, Yakovleva, Lyudmila, Shuman, Stewart, and Jinks-Robertson, Sue
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- 2024
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22. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain
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Ferguson, Cole J, Urso, Olivia, Bodrug, Tatyana, Gassaway, Brandon M, Watson, Edmond R, Prabu, Jesuraj R, Lara-Gonzalez, Pablo, Martinez-Chacin, Raquel C, Wu, Dennis Y, Brigatti, Karlla W, Puffenberger, Erik G, Taylor, Cora M, Haas-Givler, Barbara, Jinks, Robert N, Strauss, Kevin A, Desai, Arshad, Gabel, Harrison W, Gygi, Steven P, Schulman, Brenda A, Brown, Nicholas G, and Bonni, Azad
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Genetics ,Brain Disorders ,Neurosciences ,1.1 Normal biological development and functioning ,Underpinning research ,Neurological ,Adolescent ,Animals ,Antigens ,CD ,Apc7 Subunit ,Anaphase-Promoting Complex-Cyclosome ,Behavior ,Animal ,Brain ,Cadherins ,Cell Line ,Child ,Child ,Preschool ,Disease Models ,Animal ,Female ,Heterochromatin ,Humans ,Infant ,Intellectual Disability ,Intelligence ,Ki-67 Antigen ,Male ,Mice ,Inbred C57BL ,Mice ,Knockout ,Mitosis ,Mutation ,Neural Stem Cells ,Neurogenesis ,Proteolysis ,Signal Transduction ,Syndrome ,Ubiquitination ,Young Adult ,APC7 ,Cdh1 ,Ki-67 ,anaphase-promoting complex ,brain ,chromatin ,heterochromatin ,neurodevelopment ,ubiquitin ,ubiquitin ligase ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Neurodevelopmental cognitive disorders provide insights into mechanisms of human brain development. Here, we report an intellectual disability syndrome caused by the loss of APC7, a core component of the E3 ubiquitin ligase anaphase promoting complex (APC). In mechanistic studies, we uncover a critical role for APC7 during the recruitment and ubiquitination of APC substrates. In proteomics analyses of the brain from mice harboring the patient-specific APC7 mutation, we identify the chromatin-associated protein Ki-67 as an APC7-dependent substrate of the APC in neurons. Conditional knockout of the APC coactivator protein Cdh1, but not Cdc20, leads to the accumulation of Ki-67 protein in neurons in vivo, suggesting that APC7 is required for the function of Cdh1-APC in the brain. Deregulated neuronal Ki-67 upon APC7 loss localizes predominantly to constitutive heterochromatin. Our findings define an essential function for APC7 and Cdh1-APC in neuronal heterochromatin regulation, with implications for understanding human brain development and disease.
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- 2022
23. Intermediate Task Ensembling for Sarcasm Detection.
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Jarrad Jinks
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- 2023
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24. Intermediate Task Ensembling for Sarcasm Detection
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Jinks, Jarrad, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bramer, Max, editor, and Stahl, Frederic, editor
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- 2023
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25. Stop the Bleed Training for High School Students: Guardian Attitudes and Their Association with Prior Trauma
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McDade, Jessica E., Deming, Hannah C., Jinks-Chang, Samara, Paulsen, Maria R., Bui, Anthony L., Vavilala, Monica S., Rivara, Frederick P., and Bulger, Eileen M.
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Background: Uncontrolled bleeding is the leading preventable cause of death after injury. Stop the Bleed (STB) is a bleeding control training with proposed expansion into schools. However, the attitudes of guardians, specifically those with past trauma/injury, towards expanding STB into schools are unknown. Methods: A cross-sectional survey evaluated guardian attitudes towards STB training in high schools, and compared responses between guardians based on the experience of prior trauma. Logistic regression models evaluated the association between prior trauma and guardian-reported acceptability of STB training. Results: Of 750 guardians who received the survey, 484 (64.5%) responded. Most guardians (95.3%) wanted their child trained. Few (4.2%) felt this training would be harmful; 44.9% felt their child might be held responsible if something went wrong, and 28.4% reported it might be too scary for their child. In adjusted models, guardians with prior trauma were more likely to want their child trained (odds ratio [OR] = 3.50, 95% confidence interval [CI] 1.11-15.50), and identify STB as important to them (OR = 4.07, 95% CI 1.66-12.26). Conclusion: Our results support STB training in high schools, and guardians with a trauma history may be more likely to want their child trained. Further work to understand the perceived potential harm, and work to design trauma-informed first-response trainings is warranted.
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- 2022
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26. Child Development Center parents hit unexpectedly with its August closure - The Eagle
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Jinks, Luna
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News, opinion and commentary ,Sports and fitness ,American University - Abstract
Byline: Luna Jinks When American University announced in June it would be closing its Child Development Center permanently at the end of August, parents were blindsided. The CDC was an [...]
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- 2024
27. Do Teaching Staff in Primary Schools Perceive Any Impacts of School-Based Counselling on School Engagement?
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Raynham, Helen and Jinks, Gordon
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Teaching assistants and teachers (N = 186) in Cambridgeshire primary schools in the UK were invited to participate in a survey to explore the perceived impact of school-based counselling (SBC) on pupils' cognitive, social, and emotional engagement. Participants were also asked which of these factors they believed were most important to a child's educational progress. T-tests and one-way ANOVAs were conducted to explore the findings. Perceived effects of SBC were greatest on pupils' social engagement (M = 18.05, SD = 4.17), followed by emotional engagement (M = 16.71, SD = 5.24) and cognitive engagement (M = 15.08, SD = 3.96). Emotional engagement was reported as the most important factor in a child's educational progress X[superscript 2][subscript (2, n = 169)] = 77.834, p < 0.0001.
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- 2022
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28. A Comparative Study Examining the Impact of New Jersey Senate Bill S-2 on Student Academic Performance on Standardized Assessments
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Jr. Roger A. Jinks
- Abstract
This study examined budgets for public school districts in New Jersey, changes in state aid allocation for schools following the implementation of New Jersey Senate Bill S-2 (S-2), and student academic performance based on standardized assessments. This study examined changes in student academic performance due to the implementation of S-2. This study focused on four school districts, two K-12 school districts that experienced a reduction in state funding, and two K-12 school districts that experienced an increase in state funding due to the implementation of S-2. This study implemented a causal-comparative research approach to examine differences in student achievement and budget data among the selected four school districts. The student academic performance data was retrieved from the New Jersey Department of Education's website and included the percentage of students in the four districts who were proficient in English language arts and mathematics on the New Jersey Student Learning Assessment (NJSLA) from the 2018-2019 school year compared to the same academic performance data for students as measured by the Partnership for Assessment of Readiness for College and Careers (PARCC) assessments from the 2016-2017 and 2017-2018 school years. The study compared district spending for the same 3 years to determine what changes in spending on instruction and professional development occurred after S-2. Study results indicated that there was no measurable impact on student academic performance among students in these four districts after the implementation of S-2. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2022
29. Land, metal, and community : a depositional analysis of Iron Age iron objects in Britain
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Jinks-Fredrick, Zechariah A.
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936.1 ,History - Abstract
Hingley (2006) indicates it is the specific contexts for iron object depositions which are of primary concern to their depositors. This will be tested further within this research. Here it will be argued, deposits of iron objects include both those which are routine and part of daily praxes, and others which are manufactured, carefully being used as social conversations for place-making. The social and technical aspects of the chaîne opératoire of iron objects will be explored and the relationship this may have to deposition, fully considered. The exploration for the motivations behind place-making will consider both the social and technical biographies of place or space and iron objects within. As a practising blacksmith, the author will add commentary to the performativity of craftsperson(s) producing iron and manufacturing objects. Deposition represent people's connection to both social phenomena and routine practicalities as they move from place to place and engage in daily and ritual activity (Chadwick, 2012, 2014). Chadwick (2014) also suggests the meaning of demarcation through deposition or construction can never be fully understood by people of the present. Despite this, direct correlations between space, place, and practiced activity often with specific objects, like those of iron, may be observed in Iron Age and Roman Britain (Haselgrove and Hingley, 2006; Bradley, 2016; Rippon, 2018; Wilkinson, 2019; Bland et al., 2020). This research will further identify regional patterns in the depositional tradition of iron objects in non-burial contexts and seek further expand on what is known of deposition in Iron Age Britain.
- Published
- 2020
30. Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast
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Williams, Jonathan D., Zhu, Demi, García-Rubio, María, Shaltz, Samantha, Aguilera, Andrés, and Jinks-Robertson, Sue
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- 2023
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31. Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition
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Tye, Emily X. C., Jinks, Elizabeth, Haigh, Tracey A., Kaul, Baksho, Patel, Prashant, Parry, Helen M., Newby, Maddy L., Crispin, Max, Kaur, Nayandeep, Moss, Paul, Drennan, Samantha J., Taylor, Graham S., and Long, Heather M.
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- 2022
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32. Protecting Prisoners of War in Contemporary Conflicts
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Jinks, Derek, primary
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- 2023
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33. Intermediate Task Ensembling for Sarcasm Detection
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Jinks, Jarrad, primary
- Published
- 2023
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34. A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships
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Goethals, Olivia, Voge, Natalia V., Kesteleyn, Bart, Chaltin, Patrick, Jinks, Tim, De Marez, Tine, Koul, Anil, Draghia-Akli, Ruxandra, Neyts, Johan, and Van Loock, Marnix
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- 2023
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35. A cell-based, SARS-CoV-2 spike protein interaction assay to inform the neutralising capacity of recombinant and patient sera antibodies
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Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Zania Stamataki, and Omar S. Qureshi
- Subjects
SARS-CoV-2 ,ACE2 ,spike protein ,antibody discovery ,virology ,variant ,Microbiology ,QR1-502 - Abstract
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine elicited serum antibodies. The emergence of SARS-CoV-2 variants has necessitated the development of adaptable assays that can be applied to assess the effectiveness of antibody-based therapeutics.MethodsThrough the testing of a range of recombinant spike proteins, we have developed a cell-based, ACE2/spike protein interaction assay that characterises monoclonal anti-spike protein antibodies and neutralising antibodies in donor serum. The assay uses high-content imaging to quantify cell-bound spike protein fluorescence.ResultsUsing spike proteins from the original “Wuhan” SARS-CoV-2 strain and the Delta and Omicron variants, we identified differential blocking activity of three monoclonal antibodies directed against the spike receptor-binding domain. Importantly, biological activity in the spike interaction assay translated to efficacy in a SARS-CoV-2 infection assay.DiscussionThe spike protein interaction assay can be used to monitor anti-spike antibodies against the major known SARS-CoV-2 variants and is readily adaptable for quantification of the impact of antibodies against new and emerging SARS-CoV-2 variants.
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- 2023
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36. The effect of temperature during cone and seed development on primary dormancy of Scots pine (Pinus sylvestris L.) seeds
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McCartan, Shelagh A., Forster, Jack, Jinks, Richard L., Rampart, Melusi P., and Cahalan, Christine M.
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- 2022
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37. Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae.
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Jenkins, Shirin S, Gore, Steven, Guo, Xiaoge, Liu, Jie, Ede, Christopher, Veaute, Xavier, Jinks-Robertson, Sue, Kowalczykowski, Stephen C, and Heyer, Wolf-Dietrich
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Saccharomyces cerevisiae ,DNA Helicases ,Saccharomyces cerevisiae Proteins ,Amino Acid Substitution ,Crossing Over ,Genetic ,Binding Sites ,Protein Binding ,Rad51 Recombinase ,DNA repair ,crossover control ,genome stability ,helicase ,protein interaction ,recombination ,Crossing Over ,Genetic ,Genetics ,Developmental Biology - Abstract
Saccharomyces cerevisiae Srs2, in addition to its well-documented antirecombination activity, has been proposed to play a role in promoting synthesis-dependent strand annealing (SDSA). Here we report the identification and characterization of an SRS2 mutant with a single amino acid substitution (srs2-F891A) that specifically affects the Srs2 pro-SDSA function. This residue is located within the Srs2-Rad51 interaction domain and embedded within a protein sequence resembling a BRC repeat motif. The srs2-F891A mutation leads to a complete loss of interaction with Rad51 as measured through yeast two-hybrid analysis and a partial loss of interaction as determined through protein pull-down assays with purified Srs2, Srs2-F891A, and Rad51 proteins. Even though previous work has shown that internal deletions of the Srs2-Rad51 interaction domain block Srs2 antirecombination activity in vitro, the Srs2-F891A mutant protein, despite its weakened interaction with Rad51, exhibits no measurable defect in antirecombination activity in vitro or in vivo Surprisingly, srs2-F891A shows a robust shift from noncrossover to crossover repair products in a plasmid-based gap repair assay, but not in an ectopic physical recombination assay. Our findings suggest that the Srs2 C-terminal Rad51 interaction domain is more complex than previously thought, containing multiple interaction sites with unique effects on Srs2 activity.
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- 2019
38. Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.
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Klein, Hannah L, Bačinskaja, Giedrė, Che, Jun, Cheblal, Anais, Elango, Rajula, Epshtein, Anastasiya, Fitzgerald, Devon M, Gómez-González, Belén, Khan, Sharik R, Kumar, Sandeep, Leland, Bryan A, Marie, Léa, Mei, Qian, Miné-Hattab, Judith, Piotrowska, Alicja, Polleys, Erica J, Putnam, Christopher D, Radchenko, Elina A, Saada, Anissia Ait, Sakofsky, Cynthia J, Shim, Eun Yong, Stracy, Mathew, Xia, Jun, Yan, Zhenxin, Yin, Yi, Aguilera, Andrés, Argueso, Juan Lucas, Freudenreich, Catherine H, Gasser, Susan M, Gordenin, Dmitry A, Haber, James E, Ira, Grzegorz, Jinks-Robertson, Sue, King, Megan C, Kolodner, Richard D, Kuzminov, Andrei, Lambert, Sarah Ae, Lee, Sang Eun, Miller, Kyle M, Mirkin, Sergei M, Petes, Thomas D, Rosenberg, Susan M, Rothstein, Rodney, Symington, Lorraine S, Zawadzki, Pawel, Kim, Nayun, Lisby, Michael, and Malkova, Anna
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DNA breaks ,DNA repair centers ,DNA resection ,DSBs ,Holliday junctions ,R-loops ,chromatin dynamics ,chromosome rearrangements ,crossovers ,fluorescent proteins ,gene amplification ,gene conversion ,genome instability ,gross chromosome rearrangements ,homologous recombination ,mitotic recombination ,mutagenesis ,pulsed field gel electrophoresis ,replication fork stalling ,single-particle tracking ,sister chromatid recombination ,sister repetitive sequences ,site-specific chromosome breaks ,toxic recombination intermediates ,yeast artificial chromosome - Abstract
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be manipulated. Cellular assays comprise genetic, molecular, and cytological reporters. The assays are powerful tools but each comes with its particular advantages and limitations. Here the most commonly used assays are reviewed, discussed, and presented as the guidelines for future studies.
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- 2019
39. Neonates undergoing pyloric stenosis repair are at increased risk of difficult airway management: secondary analysis of the NEonate and Children audiT of Anaesthesia pRactice IN Europe
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Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Catherine, Amory, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau Cécile Magne, Caroline, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, Brière, François de la, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Izzo, Francesca, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Federico, Bilotta, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Bystrica, Banská, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela Pirtovšek, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, Serrano, Cristina González, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, García, Ernesto Martínez, Tormo de las Heras, Carolina, Montero, Pablo Troncoso, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Comas, Montserrat Suarez, Escribá, Francisco, Auli, Cristina, Pardo, Osvaldo Pérez, Biddle, Natalia Sierra, Castaño, Ceferina Suárez, Villalobos Rico, María Isabel, Muñoz, Susana Manrique, Martínez, Irene García, Estruch, Nuria Montferrer, Ortíz, Elena Vilardell, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet Wolfe, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano Scalia, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Engelhardt, Thomas, Hansen, Tom G., de Graaff, Jurgen C., and Virag, Katalin
- Published
- 2022
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40. Incorporating FRAX into a nurse-delivered integrated care review: a multi-method qualitative study
- Author
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Ashley Hawarden, Laurna Bullock, Carolyn A Chew-Graham, Daniel Herron, Samantha Hider, Clare Jinks, Risni Erandie Ediriweera De Silva, Annabelle Machin, and Zoe Paskins
- Subjects
osteoporosis ,multimorbidity ,primary health care ,review ,fracture ,qualitative methods ,Medicine (General) ,R5-920 - Abstract
Background: People with inflammatory rheumatological conditions (IRCs) are at increased risk of common comorbidities including osteoporosis. Aim: To explore the barriers to and facilitators of implementing nurse-delivered fracture risk assessments in primary care, in the context of multimorbidity reviews for people with IRCs. Design & setting: A multi-method qualitative study in primary care. Method: As part of a process evaluation in a pilot trial, semi-structured interviews were conducted with 20 patients, two nurses, and three GPs. Twenty-four patient–nurse INCLUDE review consultations were audiorecorded and transcribed. A framework analysis was conducted using the Theoretical Domains Framework (TDF). Results: Nurses reported positive views about the value of the Fracture Risk Assessment Tool (FRAX) and they felt confident to deliver the assessments following training. Barriers to implementation, as identified by TDF, particularly related to the domains of knowledge, skills, professional roles, and environmental context. GPs reported difficulty keeping up to date with osteoporosis guidelines and voiced differing opinions about whether fracture risk assessment was the role of primary or secondary care. Lack of integration of FRAX into IT systems was a barrier to use. GPs and nurses had differing views about the nurse role in communicating risk and acting on FRAX findings; for example, explanations of the FRAX result and action needed were limited. Patients reported limited understanding of FRAX outcomes. Conclusion: The findings suggest that, with appropriate training including risk communication, practice nurses are likely to be confident to play a key role in conducting fracture risk assessments, but further work is needed to address the barriers identified.
- Published
- 2023
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41. Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection
- Author
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Tut, Gokhan, Lancaster, Tara, Butler, Megan S., Sylla, Panagiota, Spalkova, Eliska, Bone, David, Kaur, Nayandeep, Bentley, Christopher, Amin, Umayr, Jadir, Azar T., Hulme, Samuel, Ayodel, Morenike, Dowell, Alexander C., Pearce, Hayden, Zuo, Jianmin, Margielewska-Davies, Sandra, Verma, Kriti, Nicol, Samantha, Begum, Jusnara, Jinks, Elizabeth, Tut, Elif, Bruton, Rachel, Krutikov, Maria, Shrotri, Madhumita, Giddings, Rebecca, Azmi, Borscha, Fuller, Chris, Irwin-Singer, Aidan, Hayward, Andrew, Copas, Andrew, Shallcross, Laura, and Moss, Paul
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- 2022
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42. Acceptability of, and preferences for, remote consulting during COVID-19 among older patients with two common long-term musculoskeletal conditions: findings from three qualitative studies and recommendations for practice
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Zoe Paskins, Laurna Bullock, Fay Manning, Simon Bishop, Paul Campbell, Elizabeth Cottrell, G. P. Partner, Clare Jinks, Melanie Narayanasamy, Ian C. Scott, Opinder Sahota, and Sarah Ryan
- Subjects
Telemedicine ,Remote consultation ,Osteoporosis ,Rheumatoid arthritis ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Guidance for choosing face-to-face vs remote consultations (RCs) encourages clinicians to consider patient preferences, however, little is known about acceptability of, and preferences for RCs, particularly amongst patients with musculoskeletal conditions. This study aimed to explore the acceptability of, and preferences for, RC among patients with osteoporosis and rheumatoid arthritis. Methods Three UK qualitative studies, exploring patient experiences of accessing and receiving healthcare, undertaken during the pandemic, with people with osteoporosis and rheumatoid arthritis. Study team members agreed a consistent approach to conduct rapid deductive analysis using the Theoretical Framework of Acceptability (TFA) on transcripts from each data set relating to RC, facilitated by group meetings to discuss interpretations. Findings from the three studies were pooled. Results Findings from 1 focus group and 64 interviews with 35 people were included in the analysis. Participants’ attitudes to RC, views on fairness (ethicality) and sense-making (intervention coherence) varied according to their needs within the consultation and views of the pandemic. Some participants valued the reduced burden associated with RC, while others highly valued non-verbal communication and physical examination associated with face-to-face consults (opportunity costs). Some participants described low confidence (self-efficacy) in being able to communicate in RCs and others perceived RCs as ineffective, in part due to suboptimal communication. Conclusions Acceptability of, and preferences for RC appear to be influenced by societal, healthcare provider and personal factors and in this study, were not condition-dependant. Remote care by default has the potential to exacerbate health inequalities and needs nuanced implementation.
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- 2022
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43. The biocompatibility and adhesive properties of polymer-clay nanocomposite hydrogels
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Jinks, Laura
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610.28 ,hydrogels ,laponite ,peel test ,lysine ,polymer brush ,DMAA ,cells ,materials ,UV ,neurite ,ARGET ATRP ,SHSY-5Y - Abstract
Clay–polymer nanocomposite hydrogels represent an increasingly utilised material for use in biomedical applications. Because of their enhanced mechanical properties compared to traditionally cross-linked materials, they are lending themselves to a wide variety of potential applications. One such possibility is the use in neural controlled next-generation prostheses. As part of their development, it was necessary to investigate the ability of these hydrogels to produce coherent layers to determine their ability to be used in additive manufacturing systems. Additionally, cell studies can be undertaken to investigate the in vitro biocompatibility of these materials on neuronal cells, thereby assessing their ability to be used in a device demonstrating neural control. In order to conduct peel and pull apart adhesion testing, a novel method of attaching the hydrogel to a stiffer substrate required developing. This involved the use of atoms regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) to grow polymer brushes onto an aluminium substrate. The adhesion of the hydrogel was then facilitated by polymerising the precursor liquid in contact with the polymer brush. This research demonstrates the adhesive properties and biocompatibility of laponite–polymer nanocomposite hydrogels. It also investigates the use of poly(D-lysine) coatings to improve the cellular attachment and differentiation of human lymphoblastoma SH-SY5Y cells when seeded onto these materials. Using a combination of peel and pull apart tests, the adhesive properties of these hydrogels have begun to be elucidated in order to assess the ability of layer-by-layer formation. The data showed that thermal initiated materials produce hydrogels with inferior adhesive ability compared to UV-initiated materials. The adhesion tests on the UV-initiated materials showed that the hydrogel attached more firmly to the polymer-brush coated substrate than to layers of itself. This demonstrated that it is possible to utilise polymer brushes as an attachment mechanism to attach hydrogels to other materials, as the attachment to the polymer brush was greater than the internal strength of the hydrogel. In testing the biocompatibility of these materials, it was shown that the thermal- initiated samples provided a greater reduction in the cell attachment compared to the UV-initiated materials. Irgacure 184 is also widely known to be a less biocompatible initiator than Irgacure 2959. Finally, poly(D-lysine) coating of nanocomposite hydrogels were shown to increase the biocompatibility of the Irgacure 184 initiated samples as shown by the increase in cell attachment and the increase in the average length of neurites. These coatings did not affect the differentiation of SH-SY5Y cells into a neuronal phenotype, as demonstrated by no change in the average number of neurites or the average length of the neurites on all other samples. UV-initiated hydrogels have begun to demonstrate the properties required in an additively manufactured prosthetic device exhibiting neural control. Future work is necessary to further develop the potential to provide guided neuronal growth.
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- 2018
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44. Barrier-Forming Potential of Epithelial Cells from the Exstrophic Bladder
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Hinley, Jennifer, Duke, Rosalind, Jinks, Jessica, Stahlschmidt, Jens, Keene, David, Cervellione, Raimondo M., Mushtaq, Imran, De Coppi, Paolo, Garriboli, Massimo, and Southgate, Jennifer
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- 2022
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45. Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection.
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Woodcock, Charlotte, Cornwall, Nicola, Harrisson, Sarah A, Jinks, Clare, Buttery, Alison, Ashworth, Julie, Mallen, Christian D, and Dikomitis, Lisa
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CHRONIC pain treatment ,CHRONIC pain & psychology ,SOCIAL media ,PATIENT selection ,HUMAN services programs ,COMPUTER software ,INTERPROFESSIONAL relations ,HUMAN research subjects ,INTERVIEWING ,INTERNET ,DISCUSSION ,CONTENT mining ,RESEARCH methodology ,PAIN management ,HEALTH promotion ,BLOGS ,PATIENTS' attitudes - Abstract
Introduction: Understanding patients' experiences is important when developing interventions for people living with persistent pain. Interviews and focus groups are frequently used to capture beliefs, views, and perspectives. These methods often require a commitment to a predetermined date and time that may present a barrier to participation. An asynchronous online discussion forum, specifically designed for research purposes, provides an alternative and potentially more accessible method for participation. In this article we discuss a bespoke online discussion forum, the Q-PROMPPT blog, as a case example. Methods: We describe how we developed the Q-PROMPPT blog, with patient and public involvement, and its use as an innovative method for qualitative data collection in the context of developing an intervention for patients prescribed opioids for persistent pain. Drawing on our experiences we discuss the following areas: planning and design, participant recruitment and registration, and participant experience and engagement. Results: We identify and address key concerns for each area of the Q-PROMPPT blog: planning and design: choosing software, assigning roles, designing the interface to promote usability; recruitment of participants: recruiting eligible participants, participant anonymity; participant experience and engagement: mitigating risk of harm, facilitating discussions, planning for forum close. Conclusion: Based on our lessons learnt, we outline recommendations for using a bespoke online discussion forum as a qualitative method to inform intervention development for people living with persistent pain. These include collaboration with information communication technology teams, co-design with patient and public partners, minimising risk of imposter participants and developing trust and online community identity. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study.
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Woodcock, Charlotte, Cornwall, Nicola, Dikomitis, Lisa, Harrisson, Sarah A., White, Simon, Helliwell, Toby, Knaggs, Roger, Hodgson, Eleanor, Pincus, Tamar, Santer, Miriam, Mallen, Christian D., Ashworth, Julie, and Jinks, Clare
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INAPPROPRIATE prescribing (Medicine) ,HEALTH literacy ,HUMAN services programs ,RESEARCH funding ,QUALITATIVE research ,SELF-management (Psychology) ,PRIMARY health care ,INTERVIEWING ,MEDICATION error prevention ,PATIENT care ,BEHAVIOR ,THEMATIC analysis ,PAIN ,OPIOID analgesics ,RESEARCH methodology ,CONCEPTUAL structures ,HEALTH behavior ,MEDICATION therapy management ,PAIN management ,PATIENT-professional relations ,HOSPITAL pharmacies ,PATIENTS' attitudes ,PATIENT participation - Abstract
Background: Opioids are frequently prescribed for persistent non-cancer pain despite limited evidence of long-term effectiveness and risk of harm. Evidence-based interventions to address inappropriate opioid prescribing are lacking. Aim: To explore perspectives of people living with persistent pain to understand barriers and facilitators in reducing opioids in the context of a pharmacist-led primary care review, and identify review components and features for optimal delivery. Design & setting: A multi-method qualitative study undertaken in the primary care setting in the UK. Method: Adults with experience of persistent pain and taking opioids participated in semi-structured interviews (n = 15, 73% female) and an online discussion forum (n = 31). The Theoretical Domains Framework (TDF) provided a framework for data collection and thematic analysis, involving deductive analysis to TDF domains, inductive analysis within domains to generate sub-themes, and sub-theme comparison to form across-domain overarching themes. The behaviour change technique taxonomy (v1) and motivational behaviour change technique classification system were used to systematically map themes to behaviour change techniques to identify potential review components and delivery features. Results: Thirty-two facilitator and barrier sub-themes for patients reducing opioids were identified across 13 TDF domains. These combined into the following six overarching themes: learning to live with pain; opioid reduction expectations; assuming a medical model; pharmacist-delivered reviews; pharmacist-patient relationship; and patient engagement. Sub-themes mapped to 21 unique behaviour change techniques, yielding 17 components and five delivery features for the proposed PROMPPT review. [ABSTRACT FROM AUTHOR]
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- 2024
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47. Reviews for multimorbidity risk in people with inflammatory conditions: a qualitative study.
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Gray, Lauren, Bullock, Laurna, Chew-Graham, Carolyn A., Jinks, Clare, Paskins, Zoe, and Hider, Samantha
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CHRONIC disease risk factors ,RISK assessment ,RESEARCH funding ,QUALITATIVE research ,FOCUS groups ,SECONDARY care (Medicine) ,INTERVIEWING ,PRIMARY health care ,DESCRIPTIVE statistics ,THEMATIC analysis ,SOUND recordings ,ATTITUDES of medical personnel ,RESEARCH methodology ,PUBLISHING ,INFLAMMATION ,DATA analysis software ,RHEUMATISM ,COMORBIDITY ,PATIENTS' attitudes ,DISEASE risk factors ,DISEASE complications - Abstract
Background: People with inflammatory rheumatological conditions (IRCs) are at high risk of developing other conditions including cardiovascular disease (CVD) and mood disorders. Aim: To explore perspectives of people with IRCs and healthcare practitioners (HCPs) on the content and delivery of a review consultation aimed at identification and management of multiple long-term conditions (mLTCs). Design & setting: Semi-structured interviews and focus groups with people with IRCs and HCPs in primary and secondary care. Method: People with IRCs participated in individual semi-structured interviews by telephone or online platform. HCPs (including primary and secondary care clinicians) participated in online focus groups. Data were transcribed verbatim and analysed using inductive thematic analysis. Results: Fifteen people with IRCs were interviewed; three focus groups with HCPs were conducted. The following two main themes were identified: reflecting on the value of review consultations; and what would a new review look like? Overall, people with IRCs and HCPs reflected that access to reviews is inequitable, leading to duplication of reviews and fragmentation in care. People with IRCs, at times, had difficulty conceptualising reviews, especially when discussing their future risk of conditions. People suggested that preparation before the healthcare review could align patient and HCP agendas as part of a flexible and person-centred discussion. Conclusion: Any review introduced for people with IRCs must move beyond a 'tick-box' exercise. To gain maximum value from a review, preparation from both patient and HCP may be required alongside a person-centred approach while ensuring they are targeted at people most likely to benefit. [ABSTRACT FROM AUTHOR]
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- 2024
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48. A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes
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de Juan, Alberto, Lozano, David, Heard, Andrew W., Jinks, Michael A., Suarez, Jorge Meijide, Tizzard, Graham J., and Goldup, Stephen M.
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- 2022
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49. Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection
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Dowell, Alexander C., Butler, Megan S., Jinks, Elizabeth, Tut, Gokhan, Lancaster, Tara, Sylla, Panagiota, Begum, Jusnara, Bruton, Rachel, Pearce, Hayden, Verma, Kriti, Logan, Nicola, Tyson, Grace, Spalkova, Eliska, Margielewska-Davies, Sandra, Taylor, Graham S., Syrimi, Eleni, Baawuah, Frances, Beckmann, Joanne, Okike, Ifeanyichukwu O., Ahmad, Shazaad, Garstang, Joanna, Brent, Andrew J., Brent, Bernadette, Ireland, Georgina, Aiano, Felicity, Amin-Chowdhury, Zahin, Jones, Samuel, Borrow, Ray, Linley, Ezra, Wright, John, Azad, Rafaq, Waiblinger, Dagmar, Davis, Chris, Thomson, Emma C., Palmarini, Massimo, Willett, Brian J., Barclay, Wendy S., Poh, John, Amirthalingam, Gayatri, Brown, Kevin E., Ramsay, Mary E., Zuo, Jianmin, Moss, Paul, and Ladhani, Shamez
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- 2022
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50. Acceptability of, and preferences for, remote consulting during COVID-19 among older patients with two common long-term musculoskeletal conditions: findings from three qualitative studies and recommendations for practice
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Paskins, Zoe, Bullock, Laurna, Manning, Fay, Bishop, Simon, Campbell, Paul, Cottrell, Elizabeth, Partner, G. P., Jinks, Clare, Narayanasamy, Melanie, Scott, Ian C., Sahota, Opinder, and Ryan, Sarah
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- 2022
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