418 results on '"Jinhua Zhan"'
Search Results
2. Enhancing the Activity of Silver Nanowire Membranes by Electrochemical Cyclic Voltammetry as Highly Sensitive Flexible SERS Substrate for On-Site Analysis
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Rui Zhang, Yongchao Lai, and Jinhua Zhan
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surface-enhanced Raman spectroscopy ,nanostructures reconstitution ,silver nanowires ,cyclic voltammetry ,swabbing extraction ,Chemistry ,QD1-999 - Abstract
The development of high-quality flexible surface-enhanced Raman spectroscopy (SERS) substrates is crucial for developing rapid SERS analysis in situ. Silver nanowire membranes as novel flexible substrates could benefit from the high collection efficiency of analytes by wrapping complex surfaces or wiping the surfaces of samples. However, their low SERS performance impedes further applications of silver nanowire membranes in analyte detection. Herein, we report an ultra-high-sensitivity silver nanowire membrane synthesized by a simple and time-saving cyclic voltammetry (CV) method. After CV treatment, a part of the silver nanowires on the silver nanowire membrane turned into small nanoparticles and nanorods. This nanostructure’s reconstitution increased the analytical enhancement factor of silver nanowire membranes by 14.4 times. Scanning and transmission electron microscopy, UV-vis spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy were employed to investigate the transformation in the membrane nanostructure. The CV-treated substrates exhibited high surface-enhanced Raman activity and good temporal stability. The limits of detection (LODs) for p-aminothiophenol, crystal violet, tetramethylthiuram disulfide, sodium perchlorate, malachite green, fluoranthene, and potassium nitrate are 3.7 × 10−12 M, 5.1 × 10−11 M, 5.4 × 10−11 M, 6.3 × 10−9 M, 0.00693 ng, 0.0810 ng, and 0.0273 ng on this substrate, respectively. Additionally, the developed substrate is feasible for the detection of crystal violet in real samples. These results certify that CV-treated substrates possess broad application prospects in on-site SERS analysis.
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- 2021
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3. A 200 kW high-efficiency and high-power density xEV motor controller based on discrete SiC MOSFET devices.
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Zhenmin Wang, Bende Luo, Jinhua Zhan, Hao Zhou, Xubiao Zhan, Tao Li, Chunxian Ye, and Jiyu Tian
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- 2022
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4. Directionally Exfoliated Ni/Co Hydroxide-Organic Framework Nanosheets for Enhanced Wearable Glucose Sensing.
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Xiangyu Kong, Xiaoyue Shi, Fanhong Min, Zhenhuai Ma, Jinhua Zhan, and Bin Cai
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- 2024
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5. Biocompatible carbon nitride quantum dots nanozymes with high nitrogen vacancies enhance peroxidase-like activity for broad-spectrum antibacterial
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Xiaohui Dai, Huan Liu, Wenxiao Du, Jie Su, Lingshuai Kong, Shouqing Ni, and Jinhua Zhan
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General Materials Science ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics - Published
- 2023
6. A Multifunctional, Highly Biocompatible, and Double-Triggering Caramelized Nanotheranostic System Loaded with Fe3O4 and DOX for Combined Chemo-Photothermal Therapy and Real-Time Magnetic Resonance Imaging Monitoring of Triple Negative Breast Cancer
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Fangqing Wang, Nianlu Li, Wenbo Wang, Long Ma, Yaru Sun, Hong Wang, Jinhua Zhan, and Dexin Yu
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Biomaterials ,International Journal of Nanomedicine ,Organic Chemistry ,Drug Discovery ,Biophysics ,Pharmaceutical Science ,Bioengineering ,General Medicine - Abstract
Fangqing Wang,1,* Nianlu Li,2,* Wenbo Wang,1 Long Ma,3 Yaru Sun,4 Hong Wang,1 Jinhua Zhan,5 Dexin Yu1 1Department of Radiology, Qilu Hospital, Shandong University, Affiliated Hospital of Shandong University, Jinan, 250012, Peopleâs Republic of China; 2Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250002, Peopleâs Republic of China; 3The Testing Center of Shandong Bureau of China Metallurgical Geology Bureau, Shandong Normal University, Jinan, 250014, Peopleâs Republic of China; 4Department of Nuclear Medicine, The Second Hospital of Shandong University, Affiliated Hospital of Shandong University, Jinan, 250033, Peopleâs Republic of China; 5School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Jinhua Zhan, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, Peopleâs Republic of China, Email jhzhan@sdu.edu.cn Dexin Yu, Department of Radiology, Qilu Hospital, Shandong University, Affiliated Hospital of Shandong University, Jinan, 250012, Peopleâs Republic of China, Tel +86-18560081629, Fax +86-531-86927544, Email yudexin0330@sina.comPurpose: Owing to lack of specific molecular targets, the current clinical therapeutic strategy for triple negative breast cancer (TNBC) is still limited. In recent years, some nanosystems for malignancy treatment have received considerable attention. In this study, we prepared caramelized nanospheres (CNSs) loaded with doxorubicin (DOX) and Fe3O4 to achieve the synergistic effect of combined therapy and real-time magnetic resonance imaging (MRI) monitoring, so as to improve the diagnosis and therapeutic effect of TNBC.Methods: CNSs with biocompatibility and unique optical properties were prepared by hydrothermal method, DOX and Fe3O4 were loaded on it to obtain Fe3O4/DOX@CNSs nanosystem. Characteristics including morphology, hydrodynamic size, zeta potentials and magnetic properties of Fe3O4/DOX@CNSs were evaluated. The DOX release was evaluated by different pH/near-infrared (NIR) light energy. Biosafety, pharmacokinetics, MRI and therapeutic treatment of Fe3O4@CNSs, DOX and Fe3O4/DOX@CNSs were examined in vitro or in vivo.Results: Fe3O4/DOX@CNSs has an average particle size of 160 nm and a zeta potential of 27.5mV, it demonstrated that Fe3O4/DOX@CNSs is a stable and homogeneous dispersed system. The hemolysis experiment of Fe3O4/DOX@CNSs proved that it can be used in vivo. Fe3O4/DOX@CNSs displayed high photothermal conversion efficiency, extensive pH/heat-induced DOX release. 70.3% DOX release is observed under the 808 nm laser in the pH = 5 PBS solution, obviously higher than pH = 5 (50.9%) and pH = 7.4 (less than 10%). Pharmacokinetic experiments indicated the t1/2β, and AUC0ât of Fe3O4/DOX@CNSs were 1.96 and 1.31 -fold higher than those of DOX solution, respectively. Additionally, Fe3O4/DOX@CNSs with NIR had the greatest tumor suppression in vitro and in vivo. Moreover, this nanosystem demonstrated distinct contrast enhancement on T2 MRI to achieve real-time imaging monitoring during treatment.Conclusion: Fe3O4/DOX@CNSs is a highly biocompatible, double-triggering and improved DOX bioavailability nanosystem that combines chemo-PTT and real-time MRI monitoring to achieve integration of diagnosis and treatment of TNBC.Keywords: caramelized nanotheranostic system, combining chemo-photothermal therapy, magnetic resonance imaging monitoring, double-triggering, triple negative breast cancer
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- 2023
7. Rh single-atom nanozymes for efficient ascorbic acid oxidation and detection
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Xiaoyue Shi, Juan Li, Yu Xiong, Ziyu Liu, Jinhua Zhan, and Bin Cai
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General Materials Science - Abstract
Rh single-atom nanozymes are designed to mimic the active sites of ascorbate peroxidase, based on which electrochemical sensors have been developed for efficient ascorbic acid detection.
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- 2023
8. Identification of Trace Polystyrene Nanoplastics Down to 50 nm by the Hyphenated Method of Filtration and Surface-Enhanced Raman Spectroscopy Based on Silver Nanowire Membranes
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Qing Yang, Shaoying Zhang, Jie Su, Shu Li, Xiaochen Lv, Jing Chen, Yongchao Lai, and Jinhua Zhan
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Silver ,Nanowires ,Microplastics ,Polystyrenes ,Water ,Environmental Chemistry ,General Chemistry ,Spectrum Analysis, Raman - Abstract
Nanoplastics are emerging pollutants that pose potential threats to the environment and organisms. However, in-depth research on nanoplastics has been hindered by the absence of feasible and reliable analytical methods, particularly for trace nanoplastics. Herein, we propose a hyphenated method involving membrane filtration and surface-enhanced Raman spectroscopy (SERS) to analyze trace nanoplastics in water. In this method, a bifunctional Ag nanowire membrane was employed to enrich nanoplastics and enhance their Raman spectra in situ, which omitted sample transfer and avoided losing smaller nanoplastics. Good retention rates (86.7% for 50 nm and approximately 95.0% for 100-1000 nm) and high sensitivity (down to 10
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- 2022
9. Synergistic ferroptosis-gemcitabine chemotherapy of the gemcitabine loaded carbonaceous nanozymes to enhance the treatment and magnetic resonance imaging monitoring of pancreatic cancer
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Gaorui Zhang, Nianlu Li, Yafei Qi, Quanqin Zhao, Jinhua Zhan, and Dexin Yu
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Glutathione Peroxidase ,Biomedical Engineering ,Antineoplastic Agents ,General Medicine ,Adenocarcinoma ,Deoxycytidine ,Magnetic Resonance Imaging ,Gemcitabine ,Biochemistry ,Pancreatic Neoplasms ,Biomaterials ,Cell Line, Tumor ,Ferroptosis ,Humans ,Reactive Oxygen Species ,Molecular Biology ,Peroxidase ,Biotechnology - Abstract
Pancreatic adenocarcinoma (PDAC) is one of the deadliest cancers, and it is resistant to most conventional antineoplastic therapies. To address this challenge, gemcitabine (Gem)-loaded carbonaceous nanoparticles (MFC-Gem) as nanozymes and a theranostic platform were fabricated and used for MR-guided ferroptosis-chemo synergetic therapy of PDAC. As a biocompatible carrier, MFC-Gem nanoparticles are regarded as peroxidase-like and glutathione peroxidase-like nanozymes that promote ferroptosis therapy by effectively generating ROS and consuming GSH. Meanwhile, the combination of MnFe
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- 2022
10. Optimizing the Pd Sites in Pure Metallic Aerogels for Efficient Electrocatalytic H 2 O 2 Production
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Xin Zhang, Cui Wang, Kai Chen, Adam H. Clark, René Hübner, Jinhua Zhan, Liang Zhang, Alexander Eychmüller, and Bin Cai
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2023
11. Screening of silver nanoparticles in antibacterial products by leveraging a silver nanowire membrane as a filter and amplifier
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Qing Yang, Shaoying Zhang, Shouqing Ni, Yongchao Lai, and Jinhua Zhan
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Materials Science (miscellaneous) ,General Environmental Science - Abstract
A filtration-based SERS platform was proposed to separate and analyse AgNPs in antibacterial products.
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- 2022
12. Ball milling treatment of Mn3O4 regulates electron transfer pathway for peroxymonosulfate activation
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Huan Liu, Xiaohui Dai, Lingshuai Kong, Chengji Sui, Zixuan Nie, Yang Liu, Bin Cai, Shou-Qing Ni, Grzegorz Boczkaj, and Jinhua Zhan
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
13. The Alfalfa-inpatient-CAT assessment model: a thrombotic risk assessment model for inpatient cancer patients
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Wenjun Chen, Guilan Wu, Peiguang Niu, Shuyi Wu, Meina Lv, Tingting Wu, Shaojun Jiang, and Jinhua Zhang
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Venous thromboembolism ,Cancer-associated thrombosis ,Inpatients ,Risk assessment ,Cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose To construct a venous thromboembolism (VTE) risk assessment model specifically for inpatients with cancer. Method Patients were included according to the inclusion criteria. Univariate and multivariate analyses of all variables were included to develop a VTE risk assessment model applicable to the derivation cohort. Hosmer–Lemeshow test and receiver operating characteristic (ROC) curve were used to test the fit degree and identification validity of the model. The patient data from separate validation cohorts verified the external population. Result A total of 944 cancer patients were included in this study. Alfalfa-inpatient-CAT model, a risk assessment model for VTE in hospitalized cancer patients, was established, which mainly includes hypertension, surgical history (nearly one month), history of VTE, peripherally inserted central venous catheters (PICC), chemotherapy, PT 0.05, (χ2 = 8.872, Df = 8). The area under ROC curve was 0.906 [95%CI (0.881–0.930), P
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- 2024
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14. Four new species of Russula subsect. Cyanoxanthinae from China (Russulales, Russulaceae)
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Yanliu Chen, Bin Chen, Ruoxi Liang, Shengkun Wang, Mengya An, Jinhua Zhang, Jingying Liang, Yaxin Wang, Xuelian Gao, and Junfeng Liang
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Botany ,QK1-989 - Abstract
Four new species of Russula subsect. Cyanoxanthinae, viz. Russula atrochermesina Y.L. Chen & J.F. Liang, R. lavandula Y.L. Chen, B. Chen & J.F. Liang, R. lilaceofusca Y.L. Chen & J.F. Liang and R. perviridis Y.L. Chen, B. Chen & J.F. Liang, from China are proposed, based on morphological and molecular evidence. Russula atrochermesina can be distinguished by its violet pileus with tuberculate-striate margin, distant lamellae that stain greyish-yellow when bruised, basidiospores ornamented by isolated warts, wide hymenial cystidia on lamellae edges, cystidia content negative reaction in sulphovanillin and branched subterminal cells in pileipellis. Russula lavandula has a purplish-white to violet red pileus with a yellow centre, frequently present lamellulae and furcations, stipe often with pale yellow near the base, isolated basidiospores ornamentation and unbranched cuticular hyphal terminations, while R. lilaceofusca is characterised by its lilac brown to dark brown pileus, crowded lamellae with lamellulae and furcations, stipe often turning reddish-yellow when bruised, subreticulate basidiospores ornamentation and clavate hymenial cystidia often with capitate appendage whose contents that change to reddish-black in sulphovanillin. Russula perviridis is characterised by its large basidiomata, smooth pileus surface, frequently present lamellulae and furcations, stipe with yellow-brown tinge, globose to broadly ellipsoid basidiospores with subreticulate ornamentation, long hymenial cystidia that turn greyish-black in sulphovanillin and symbiotic with Quercus semecarpifolia. Phylogenetic analyses, based on multi-gene ITS+LSU+mtSSU+rpb2, indicate that R. atrochermesina, R. lavandula, R. lilaceofusca and R. perviridis are closely related to R. pallidirosea and R. purpureorosea, R. banwatchanensis, R. lakhanpalii and R. nigrovirens, respectively.
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- 2024
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15. Interparticle Charge-Transport-Enhanced Electrochemiluminescence of Quantum-Dot Aerogels
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Xuwen Gao, Guocan Jiang, Cunyuan Gao, Anatol Prudnikau, René Hübner, Jinhua Zhan, Guizheng Zou, Alexander Eychmüller, and Bin Cai
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General Chemistry ,General Medicine ,Catalysis - Abstract
Electrochemiluminescence (ECL) represents a widely explored technique to generate light, in which the emission intensity relies critically on the charge-transfer reactions between electrogenerated radicals. Two types of charge-transfer mechanisms have been postulated for ECL generation, but the manipulation and effective probing of these routes remain a fundamental challenge. Here, we demonstrate the design of quantum dot (QD) aerogels as novel ECL luminophores via a versatile water-induced gelation strategy. The strong electronic coupling between adjacent QDs enables efficient charge transport within the aerogel network, leading to the generation of highly efficient ECL based on the selectively improved interparticle charge-transfer route. This mechanism is further verified by designing CdSe-CdTe mixed QD aerogels, where the two mechanistic routes are clearly decoupled for ECL generation. We anticipate our work will advance the fundamental understanding of ECL and prove useful for designing next-generation QD-based devices.
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- 2022
16. Synergistic Lewis acid-base sites of ultrathin porous Co3O4 nanosheets with enhanced peroxidase-like activity
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Jinhua Zhan, Lingshuai Kong, Jie Su, Zhenyu Feng, Ming Yuan, Jing Chen, Wenhui Lu, Jiaxin Zhang, and Xicheng Ma
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Radical ,Substrate (chemistry) ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Catalysis ,chemistry.chemical_compound ,Sodium borohydride ,Electron transfer ,chemistry ,Chemical engineering ,Oxidizing agent ,General Materials Science ,Lewis acids and bases ,Electrical and Electronic Engineering ,Hydrogen peroxide - Abstract
Surface Lewis acid-base sites in crystal structure may influence the physicochemical properties and the catalytic performances in nanozymes. Understanding the synergistic effect mechanism of Co3O4 nanozymes towards substances (3,3′,5,5′-tetramethylbenzidine (TMB) and hydrogen peroxide (H2O2)) induced by surface Lewis acid-base sites is important to enhance the efficiency for peroxidase-like reaction. Herein, ultrathin porous Co3O4 nanosheets with abundant Lewis acid-base sites were prepared by sodium borohydride (NaBH4) reduction treatment, which exhibited high-efficiency peroxidase-like activity compared with original Co3O4 nanosheets. The Lewis acid-base sites for ultrathin porous Co3O4 nanosheets nanozyme were owing to the coordination unsaturation of Co ions and the formation of defect structure. Ultrathin porous Co3O4 nanosheets had 18.26-fold higher catalytic efficiency (1.27 × 10−2 s−1·mM−1) than that of original Co3O4 (6.95 × 10−4 s−1·mM−1) in oxidizing TMB substrate. The synergistic effect of surface acid and base sites can enhance the interfacial electron transfer process of Co3O4 nanosheets, which can be a favor of absorption substrates and the generation of reactive intermediates such as radicals. Furthermore, the limit of detection of hydroquinol was 0.58 µM for ultrathin porous Co3O4 nanosheets, 965-fold lower than original Co3O4 (560 µM). Besides, the linear range of ultrathin porous Co3O4 nanosheets was widely with the concentration of 5.0–1,000 µM. Colorimetric detection of hydroquinol by agarose-based hydrogel membrane was provided based on excellent peroxidase-like properties. This study provided insights into designing high-performance nanozymes for peroxidase-like catalysis via a strategy of solid surface acid-base sites engineering.
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- 2021
17. Development of extraction-surface enhanced Raman spectroscopy and its application in detection of hazardous materials
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Jing Chen, Yongchao Lai, and Jinhua Zhan
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Materials science ,Hazardous waste ,General Chemical Engineering ,Extraction (chemistry) ,Materials Chemistry ,Nanotechnology ,General Chemistry ,Surface-enhanced Raman spectroscopy ,Biochemistry - Published
- 2021
18. Dynamic SPME-SERS Induced by Electric Field: Toward In Situ Monitoring of Pharmaceuticals and Personal Care Products
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Shu Li, Xiaochen Lv, Qing Yang, Shaoying Zhang, Jie Su, Shi-Bo Cheng, Yongchao Lai, Jing Chen, and Jinhua Zhan
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Pharmaceutical Preparations ,Benzidines ,Cosmetics ,Spectrum Analysis, Raman ,Solid Phase Microextraction ,Analytical Chemistry - Abstract
The core of the surface-enhanced Raman spectroscopy (SERS)-based techniques for dynamic monitoring is to realize rapid and reversible adsorption. Herein, the integration technology of electro-enhanced adsorption, solid-phase microextraction, and surface-enhanced Raman spectroscopy (EE-SPME-SERS) was developed to obtain sensitive, ultrafast, and reversible SERS response toward in situ monitoring of pharmaceuticals and personal care products (PPCPs). In the EE-SPME-SERS method, a roughened Ag fiber with Au modification (r-Ag/Au fiber) was used as the SERS substrate, SPME sorbent, and working electrode. The r-Ag/Au fiber displayed good SERS sensitivity, ultrahigh photostability, and adsorption properties. The adsorption efficiency of benzidine was 76 times accelerated in EE-SPME-SERS compared to that in static adsorption. The whole process of "sampling and detection" in EE-SPME-SERS can be finished within 1 s. Reversible adsorption and desorption can be achieved in situ by switching the direction of electric field, and the regeneration process takes only a few minutes. Simulated release of benzidine from household wastewater was in situ and dynamically monitored using this strategy. EE-SPME-SERS was proved universal for ionized PPCPs and can detect multicomponents simultaneously. In addition, EE-SPME-SERS showed very good analytical properties. Great potential of EE-SPME-SERS can be expected in environmental monitoring.
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- 2022
19. Robust, reliable and quantitative sensing of aqueous arsenic species by Surface-enhanced Raman Spectroscopy: The crucial role of surface silver ions for good analytical practice
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Xiaochen Lv, Shu Li, Qing Yang, Shaoying Zhang, Jie Su, Shi-Bo Cheng, Yongchao Lai, Jing Chen, and Jinhua Zhan
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Ions ,Silver ,Metal Nanoparticles ,Reproducibility of Results ,Water ,Spectrum Analysis, Raman ,Instrumentation ,Spectroscopy ,Atomic and Molecular Physics, and Optics ,Analytical Chemistry ,Arsenic - Abstract
Arsenic speciation analysis is important for pollution and health risk assessment. Surface-enhanced Raman Spectroscopy (SERS) is supposed to be a promising detection technology for arsenic species owing to the unique fingerprints. However, further application of SERS is hampered by its poor repeatability. Herein, the role of surface silver ions on colloidal Ag was revealed in SERS analysis of arsenic species. Arsenic species were adsorbed on Ag nanoparticles (Ag NPs) driven by surface silver ions and were simultaneously sensed by the SERS "hot spots" generated from the aggregation of Ag NPs. So, the inconsistent SERS activities of Ag NPs synthesized from different batches can be significantly improved by modifying external silver ions onto Ag NPs (AgNPs@Ag
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- 2022
20. Construction of warfarin population pharmacokinetics and pharmacodynamics model in Han population based on Bayesian method
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Xiaotong Xia, Xiaofang Cai, Jiana Chen, Shaojun Jiang, and Jinhua Zhang
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Population PK/PD model ,Warfarin ,Gene polymorphism ,Han population ,Medicine ,Science - Abstract
Abstract The purpose of this paper is to study the genetic polymorphisms of related gene loci (CYP2C9*3, VKORC1-1639G > A) based on demographic and clinical factors, and use the maximum a posterior Bayesian method to construct a warfarin individualized dose prediction model in line with the Chinese Han population. Finally, the built model is compared and analyzed with the widely used models at home and abroad. In this study, a total of 5467 INR measurements are collected from 646 eligible subjects in our hospital, and the maximum a posterior Bayesian method is used to construct a warfarin dose prediction that conforms to the Chinese Han population on the basis of the Hamberg model. The model is verified and compared with foreign models. This study finds that body weight and concomitant use of amiodarone have a significant effect on the anticoagulant effect of warfarin. The model can provide an effective basis for individualized and rational dosing of warfarin in Han population more accurately. In the performance of comparison with different warfarin dose prediction models, the new model has the highest prediction accuracy, and the prediction percentage is as high as 72.56%. The dose predicted by the Huang model is the closest to the actual dose of warfarin. The population pharmacokinetics and pharmacodynamics model established in this study can better reflect the distribution characteristics of INR values after warfarin administration in the Han population, and performs better than the models reported in the literature.
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- 2024
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21. Efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation combined with chronic kidney disease: a systematic review and meta-analysis
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Yaodi Li, Shuyi Wu, Jintuo Zhou, and Jinhua Zhang
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Direct oral anticoagulants ,Chronic kidney disease ,Kidney failure ,Atrial fibrillation ,meta-analysis ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Abstract Background Currently published studies have not observed consistent results on the efficacy and safety of direct oral anticoagulants (DOACs) use in patients with chronic kidney disease (CKD) combined with atrial fibrillation (AF). Therefore, this study conducted a meta-analysis of the efficacy and safety of DOACs for patients with AF complicated with CKD. Methods Database literature was searched up to May 30, 2023, to include randomized controlled trials (RCT) involving patients with AF complicated with CKD DOACs and vitamin K antagonists (VKAs). Stroke, systemic embolism (SE), and all-cause mortality were used as effectiveness indicators, and major bleeding, intracranial hemorrhage (ICH), fatal bleeding, gastrointestinal bleeding (GIB), and clinically relevant non-major bleeding (CRNMB) were used as safety outcomes. Results Nine RCT studies were included for analysis according to the inclusion criteria. Results of the efficacy analysis showed that compared with VKAs, DOACs reduced the incidence of stroke/SE (OR = 0.75, 95% CI 0.67–0.84) and all-cause deaths (OR = 0.84, 95% CI 0.75–0.93) in patients with AF who had comorbid CKD. Safety analyses showed that compared with VKAs, DOACs improved safety by reducing the risk of major bleeding (OR = 0.76, 95%CI 0.65–0.90), ICH (OR = 0.46, 95%CI 0.38–0.56), and fatal bleeding (OR = 0.75, 95%CI 0.65–0.87), but did not reduce the incidence of GIB and CRNMB. Conclusion Compared with VKAs, DOACs may increase efficacy and improve safety in AF patients with CKD (90 ml/min> Crcl≥15 ml/min), and shows at least similar efficacy and safety in AF patients with Kidney failure (Crcl
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- 2024
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22. Bimetallic Pt‐Hg Aerogels for Electrocatalytic Upgrading of Ethanol to Acetate
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Xin Zhang, Tao Wang, Cui Wang, René Hübner, Alexander Eychmüller, Jinhua Zhan, and Bin Cai
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Biomaterials ,General Materials Science ,General Chemistry ,Biotechnology - Published
- 2023
23. Single-atom Co-N5 catalytic sites on carbon nanotubes as peroxymonosulfate activator for sulfamerazine degradation via enhanced electron transfer pathway
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Meng Xie, Mingya Yao, Shiyong Zhang, Lingshuai Kong, Lingxi Zhao, Jinhua Zhan, and Ru-Song Zhao
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Filtration and Separation ,Analytical Chemistry - Published
- 2023
24. Stage IV ovarian cancer prognosis nomogram and analysis of racial differences: A study based on the SEER database
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Guilan Wu, Jiana Chen, Peiguang Niu, Xinhai Huang, Yunda Chen, and Jinhua Zhang
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Ovarian cancer ,SEER ,Overall survival rate ,Nomogram ,Risk stratification ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Purpose: Stage IV ovarian cancer is a tumor with a poor prognosis and lacks prognostic models. This study constructed and validated a model to predict overall survival (OS) in patients with newly diagnosed stage IV ovarian cancer. Methods: The data of this study were extracted from SEER database. Cox regression analysis was used to construct the nomogram model and implemented it in an online web application. Concordance index (C-index), calibration curve, area under receiver operating characteristic curve (ROC) and decision curve analysis (DCA) were used to verify the performance of the model. Results: A total of 6062 patients were collected in this study. The analysis showed that age, race, histological grade, histological differentiation, T stage, CA125, liver metastasis, primary site surgery, and chemotherapy were independent prognostic parameters, and were used to construct the nomogram model. The C-index of the training group and the verification group was 0.704 and 0.711, respectively. Based on the score of the nomogram responding risk classification system is constructed. The online interface of Alfalfa-IVOC-OS is free to use. In addition, the racial analysis found that Asian or Pacific Islander people had higher survival rates than white and black people. Conclusion: This study established a new survival prediction model and risk classification system designed to predict OS time in patients with stage IV ovarian cancer to help clinicians evaluate the prognosis of patients with stage IV ovarian cancer.
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- 2024
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25. Enzymatic characterization and dominant sites of foot-and-mouth disease virus 2C protein
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Saisai Zhou, Nankun Liu, Yang Tian, Hong Pan, Yang Han, Zhen Li, Jinhua Zhang, Shuaiyin Guan, Huanchun Chen, and Yunfeng Song
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FMDV ,2C protein ,Nuclease ,Helicase ,RNA chaperone ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Foot-and-mouth disease virus (FMDV) 2C protein is a conserved non-structural protein and crucial for replication of the virus. In this study, FMDV 2C protein was prepared and the enzymatic activities were investigated in detail. The protein could digest ssDNA or ssRNA into a small fragment at about 10 nt, indicating that the protein has nuclease activity. But it did not show digestion to blunt-end dsDNA or dsRNA. The nuclease activity of 2C protein could be inhibited in 2 mM Zn2+ or Ca2+ while enhanced by Mg2+ or Mn2+. FMDV 2C protein exhibited unwinding activity to all the three kinds of dsDNA and dsRNA (5′ protruded, 3′ protruded, and blunt-end). The unwinding velocity to 5′ protruded dsRNA was higher than to the blunt-end dsRNA. 2C protein only showed unwinding activity in high concentration of Mg2+, but no unwinding activity in physiological concentrations of Mg2+ and Ca2+, as well as in cell lysate. The 2C protein could catalyze two structured ssRNA to form double strand, thus it was proved to have RNA chaperone activity. The Mg2+ and ATP in different concentrations did not show promotion to the RNA chaperone activity. Finally, six mutant proteins (K116A, D160A, D170A, N207A, R226A, and F316A) were constructed and the enzymatic activities were analyzed. All the six mutations reduced the ATPase activity, D170A and F361A could inactivate the nuclease activity, while the N207A and F316A could inactivate the helicase activity. Our study provides a comprehensive understanding of the enzymatic activities of FMDV 2C protein.
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- 2024
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26. Multi-body dynamic and finite element analysis based shape optimization of flexible connection structure of On-Load Tap Changer for minimizing transient stress using Adaptive Single-Objective method
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Yicong Zhou, Yichen Wang, Ke Wang, Shuqi Zhang, Jinhua Zhang, Qiyin Lin, Jun Hong, and Yi Xiao
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On-load tap changer ,Shape optimization ,Transient stress minimization ,Multi-body dynamic ,Finite element analysis ,Adaptive single-objective optimization ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
On-Load Tap-Changer (OLTC) is the only core equipment in the ultra-high voltage (UHV) converter transformer that moves frequently, and flexible connection structure (FCS) is the moveable actuating part of the vacuum interrupter drive mechanism of OLTC. Minimizing the transient stress during the movement of FCS is essential for prolonging its fatigue life, thus is pursued by optimizing the shape of the flexible sheet in this paper. Peak transient stress of FCS is defined as the optimization objective, and eight geometrical parameters controlling the shape of flexible sheet are defined as the optimization variables. A progressive three-stage shape optimization strategy is proposed by combing four techniques: Multi-body Dynamic (MBD), Finite Element Analysis (FEA), Correlation Coefficient Analysis (CCA) and Adaptive Single-objective Optimization (ASO). MBD analysis of the vacuum interrupter drive mechanism and FEA of the FCS are utilized for calculating the transient stress distribution. Spearman CCA is performed to quantitively determine the correlation and sensitivity between the optimization variables and the optimization objective. Shape optimization of FCS using ASO is carried out, and results show that the stress concentration is basically eliminated and the peak transient stress decrease by 34.35% after shape optimization. Further analysis of the FCS with multi-layered flexible sheet is conducted, again demonstrating the effectiveness of the shape optimization on minimizing transient stress.
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- 2024
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27. Web-Based Warfarin Management (Alfalfa App) Versus Traditional Warfarin Management: Multicenter Prospective Cohort Study
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Wenfei Chen, Jiana Chen, Shaojun Jiang, Chunhua Wang, and Jinhua Zhang
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPoor anticoagulation management of warfarin may lead to patient admission, prolonged hospital stays, and even death due to anticoagulation-related adverse events. Traditional non–web-based outpatient clinics struggle to provide ideal anticoagulation management services for patients, and there is a need to explore a safer, more effective, and more convenient mode of warfarin management. ObjectiveThis study aimed to compare differences in the quality of anticoagulation management and clinical adverse events between a web-based management model (via a smartphone app) and the conventional non–web-based outpatient management model. MethodsThis study is a prospective cohort research that includes multiple national centers. Patients meeting the nadir criteria were split into a web-based management group using the Alfalfa app or a non–web-based management group with traditional outpatient management, and they were then monitored for a 6-month follow-up period to collect coagulation test results and clinical events. The effectiveness and safety of the 2 management models were assessed by the following indicators: time in therapeutic range (TTR), bleeding events, thromboembolic events, all-cause mortality events, cumulative event rates, and the distribution of the international normalized ratio (INR). ResultsThis national multicenter cohort study enrolled 522 patients between June 2019 and May 2021, with 519 (99%) patients reaching the follow-up end point, including 260 (50%) in the non–web-based management group and 259 (50%) in the web-based management group. There were no observable differences in baseline characteristics between the 2 patient groups. The web-based management group had a significantly higher TTR than the non–web-based management group (82.4% vs 71.6%, P
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- 2024
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28. Efficacy and safety of direct oral anticoagulants for preventing venous thromboembolism in hospitalized cancer patients: a national multicenter retrospective cohort study
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Shuyi Wu, Haiping Wang, Chunbao Li, Jingjing Tao, Xiaoli Zhu, Hengfen Dai, Hongfan Duan, Tian Hu, Miao Li, Fenfen Qu, Yun Wei, Chunhua Wang, and Jinhua Zhang
- Subjects
direct oral anticoagulants ,hospitalized cancer patients ,venous thromboembolism ,rivaroxaban ,low-molecular-weight heparin ,Therapeutics. Pharmacology ,RM1-950 - Abstract
IntroductionStudies on the use of direct oral anticoagulants (DOACs) for preventing venous thromboembolism (VTE) in hospitalized cancer patients are lacking. Therefore, we conducted a multicenter retrospective cohort study to evaluate the efficacy and safety of DOACs versus low-molecular-weight heparin (LMWH) for the primary prevention of VTE in hospitalized cancer patients.MethodsClinical outcomes included thrombosis, VTE, other thrombosis, all bleeding, major bleeding, nonmajor bleeding, and all-cause death. A 1:1 cohort of rivaroxaban and LMWH patients was created by propensity score matching.ResultsA total of 2,385 cancer patients were included in this study. During the 3-month follow-up period, 129 (5.4%) thrombosis events occurred, 63 (2.7%) of which were VTEs and 66 (2.8%) of which were other thrombosis events. All bleeding occurred in 163 (6.8%) patients, 68 (2.9%) had major bleeding, and 95 (4.0%) had nonmajor bleeding. All-cause deaths occurred in 113 (4.7%) patients. After adjusting for various confounders, the incidence of thrombosis and other thromboses was significantly lower in the rivaroxaban group than in the LMWH group [OR 0.543, 95% CI (0.343–0.859), p = 0.009; OR 0.461, 95% CI (0.241–0.883), p = 0.020]. There were no significant differences in incidence of VTE, total bleeding, major bleeding, nonmajor bleeding, or all-cause death.ConclusionIn oncology patients receiving thromboprophylaxis, rivaroxaban has a lower incidence of thrombosis and other thrombosis and a similar incidence of VTE as LMWH and does not increase the risk of bleeding. Rivaroxaban may be an attractive alternative to LMWH for preventing VTE in hospitalized cancer patients.
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- 2024
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29. Surface-Enhanced Raman Scattering of Phenols and Catechols by a Molecular Analogue of Titanium Dioxide
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Chen-Ho Tung, Jinhua Zhan, Feng Zhu, Yifeng Wang, Guo Wang, Caiyun Liu, Junyi Hu, and Subharanjan Biswas
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Surface (mathematics) ,010401 analytical chemistry ,Surface reaction ,010402 general chemistry ,Photochemistry ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,symbols.namesake ,chemistry.chemical_compound ,chemistry ,Titanium dioxide ,symbols ,Molecule ,Phenols ,Raman spectroscopy ,Raman scattering - Abstract
Surface-enhanced Raman spectroscopy (SERS) of semiconducting TiO2 was used for studying binding modes and surface reactions of molecules bound at the interface but is generally limited by low signa...
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- 2020
30. Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries
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Jinhua Zhan, Xue Bai, Shenqing Wang, Hongyu Zhou, Bing Yan, Virender K. Sharma, Sijin Liu, Guibin Jiang, Hao Zhu, and Xiliang Yan
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Cell Survival ,Surface Properties ,Cell ,Metal Nanoparticles ,General Physics and Astronomy ,Nanoparticle ,02 engineering and technology ,Cell fate determination ,Conjugated system ,Ligands ,010402 general chemistry ,01 natural sciences ,Tumor Cells, Cultured ,medicine ,Humans ,General Materials Science ,Particle Size ,Cytotoxicity ,Cell survival ,Platinum ,Chemistry ,Ligand ,Optical Imaging ,General Engineering ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Oxidative Stress ,Nanomedicine ,medicine.anatomical_structure ,A549 Cells ,Biophysics ,Gold ,Pt nanoparticles ,0210 nano-technology ,Hydrophobic and Hydrophilic Interactions ,Palladium - Abstract
Nanoparticle structural parameters, such as size, surface chemistry, and shape, are well-recognized parameters that affect biological activities of nanoparticles. However, whether the core material of a nanoparticle also plays a role remains unknown. To answer this long-standing question, we synthesized and investigated a comprehensive library of 36 nanoparticles with all combinations of three types of core materials (Au, Pt, and Pd), two sizes (6 and 26 nm), and each conjugated with one of six surface ligands of different hydrophobicity. Using this systematic approach, we were able to identify cellular perturbation specifically attributed to core, size, or surface ligand. We discovered that core materials exhibited a comparable regulatory ability as surface ligand on cellular ROS generation and cytotoxicity. Pt nanoparticles were much more hydrophilic and showed much less cell uptake compared to Au and Pd nanoparticles with identical size, shape, and surface ligands. Furthermore, diverse core materials also regulated levels of cellular redox activities, resulting in different cytotoxicity. Specifically, Pd nanoparticles significantly reduced cellular H2O2 and promoted cell survival, while Au nanoparticles with identical size, shape, and surface ligand induced higher cellular oxidative stress and cytotoxicity. Our results demonstrate that nanoparticle core material is as important as other structural parameters in nanoparticle-cell interactions, making it also a necessary consideration when designing nanomedicines.
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- 2019
31. Functionalization of Titanium Oxide Cluster Ti 17 O 24 (O i C 3 H 7 ) 20 with Catechols: Structures and Ligand‐Exchange Reactivities
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Jinhua Zhan, Junyi Hu, Feng Zhu, Yifeng Wang, Chen-Ho Tung, Lin Du, and Caiyun Liu
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010405 organic chemistry ,Ligand ,Chemistry ,Organic Chemistry ,Kinetics ,Supramolecular chemistry ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Titanium oxide ,Crystallography ,symbols.namesake ,symbols ,Surface modification ,Reactivity (chemistry) ,Raman spectroscopy ,Hybrid material - Abstract
The functionalization of Ti17 O24 (Oi C3 H7 )20 (Ti17 ) with substituted catechols is studied by using crystallography, Raman spectroscopy, and stopped-flow kinetics. The knowledges on the number of accessible functionalities, their exact location correlated with their Raman assignment, and the kinetic parameters are acquired. A catecholate ligand binds to a five-coordinated surface Ti of Ti17 (denoted as Tia site) adopting the mono-protonated, chelate-bidentate binding mode, whereas it binds to a six-coordinated surface-Ti (denoted as Tib site) adopting the mono-dentate mode. With low numbers of equivalents of added catechols the Tia sites show higher reactivity than the Tib sites toward functionalization. Two binding modes may co-exist and equilibrate in solution. Our results also imply that at most eight of the twenty Oi C3 H7 ligands of Ti17 are exchangeable without damage of the core structure. The kinetic studies point out that the ligand-exchange reaction is second order and occurs very fast. The current findings are helpful for the controlled functionalization of Ti17 and other Ti oxide clusters, and the further application of them as building blocks in supramolecular chemistry for the assembly of well-defined organic-inorganic hybrid materials.
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- 2019
32. Sulfate and hydroxyl radicals-initiated degradation reaction on phenolic contaminants in the aqueous phase: Mechanisms, kinetics and toxicity assessment
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Danan Han, Jianfei Sun, Xueyu Wang, Qiong Mei, Ju Xie, Jinhua Zhan, Zexiu An, Maoxia He, and Bo Wei
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Reaction mechanism ,General Chemical Engineering ,Radical ,Substituent ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Hydrogen atom abstraction ,01 natural sciences ,Medicinal chemistry ,Redox ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,chemistry.chemical_compound ,Reaction rate constant ,chemistry ,Water environment ,Environmental Chemistry ,Reactivity (chemistry) ,0210 nano-technology - Abstract
Phenolic organic contaminants (POCs) in water environment have been usually degraded by advanced oxidation processes (AOPs) based on sulfate radicals ( SO 4 · - ) and hydroxyl radicals ( OH). In this paper, the first step of SO 4 · - / · OH -initiated oxidation reactions toward 19 POCs were investigated using density functional theory (DFT) in order to explore and compare the reactivity of POCs with two free radicals in the aqueous phase. The oxidation reactions initiated by SO 4 · - / · OH were confirmed that POCs can follow three reaction mechanisms: radical adduct formation (RAF), hydrogen atom abstraction (HAA), and single electron transfer (SET). The rate constants of all primary oxidation reactions were calculated using transition state theory (TST). The results turn out that the stronger the electron donating effects of the substituent on POCs, the better the reactivity of POCs with two free radicals. SET mechanisms are main reaction pathways for SO 4 · - -initiated oxidation reactions. Furthermore, the ecotoxicity assessment shows that most OH adducts have higher toxic on aquatic organisms than corresponding reactants. For all the POCs covering in this work, the order of acute toxicity is p-DP > o-AP > m-AP (p-AP) > MP > CP > NP > m-DP (o-DP) > phenol > YP, while the chronic toxicity is in the order p-DP > o-AP > m-AP (p-AP) > MP > CP > NP > YP > phenol > m-DP (o-DP). Thus, the application of AOPs for the removal of POCs should be taken seriously.
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- 2019
33. Theoretical insights into the degradation of swep by hydroxyl radicals in atmosphere and water environment: Mechanisms, kinetics and toxicity
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Ju Xie, Zexiu An, Jinhua Zhan, Qiong Mei, Xiaofei Bo, Bo Wei, and Maoxia He
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Pollutant ,Carbamate ,Environmental Engineering ,Chemistry ,Atmosphere ,Herbicides ,Hydroxyl Radical ,Radical ,medicine.medical_treatment ,Water ,Pollution ,Kinetics ,Adsorption ,Reaction rate constant ,Environmental chemistry ,Water environment ,medicine ,Photocatalysis ,Environmental Chemistry ,Degradation (geology) ,Humans ,Waste Management and Disposal ,Oxidation-Reduction ,Water Pollutants, Chemical - Abstract
As an excellent conductive herbicide, swep is widely used in weed removal. Its remaining in atmosphere and water can not only contaminate the environment but also pose a threat to human health. This work presented a systematic theoretical study of HO•-mediated degradation mechanisms and kinetics of swep in atmosphere and water environment. HO•-addition reaction was the dominant reaction type and the main degradation products N-(3-chloro-4-hydroxyphenyl)carbamate (P2), N-(3,4-chloro-6-hydroxyphenyl)carbamate (P3) and N-(3,4-chloro-2-hydroxyphenyl)carbamate (P11) were in good agreement with the experimental results. The total rate constants of swep with HO• were determined to be 3.37 × 10−12 and 7.73 × 10−12 cm3 molecule−1 s−1 (at 298 K) in atmosphere and water environment, respectively. As an excellent adsorbent and photocatalyst, zinc oxide (ZnO) was selected to study the adsorption and catalytic degradation mechanism of swep. The adsorption configuration of (ZnO)n clusters with swep was most stable when n = 6. The adsorption of (ZnO)6 cluster was more favorable to the H-atom abstraction reaction. The toxicities of swep and its degradation products to aquatic organisms were predicted. The degradation of swep induced by HO• was beneficial to the survival of aquatic organisms. This work would provide a comprehensive theoretical basis for understanding the degradation behavior of organic pollutants.
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- 2021
34. Engineering of aerogel‐based electrocatalysts for oxygen evolution reaction
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Bin Cai, Cunyuan Gao, Jinhua Zhan, and Xin Zhang
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Materials science ,Chemical engineering ,Oxygen evolution ,Aerogel ,Porous medium ,Electrocatalyst - Published
- 2021
35. Risk factors for venous thromboembolism in a single pediatric intensive care unit in China
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Jintuo Zhou, Yanting Zhu, Ying Liu, Hairong Zhan, Peiguang Niu, Huajiao Chen, and Jinhua Zhang
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Pediatric ,Risk factors ,Venous thromboembolism ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Abstract Background Analyses of extensive, nationally representative databases indicate a rising prevalence of venous thromboembolism (VTE) among critically ill children. However, the majority of studies on childhood VTE have primarily concentrated on Caucasian populations in the United States and European countries. There is a lack of epidemiological studies on VTE in Chinese children. Methods We conducted a retrospective cohort study of data from the Pediatric Intensive Care (PIC) database. Data were obtained and extracted by using Structured Query Language (SQL) and the administrative platform pgAdmin4 for PostgreSQL. Bivariate analyses were conducted in which categorical variables were analyzed by a chi-square test and continuous variables were analyzed by a Student’s t-test. Separate multivariable logistic regressions were employed to investigate the associations between VTE and sociodemographic factors as well as clinical factors. Results Our study included 12,881 pediatric patients from the PIC database, spanning the years 2010 to 2018. The incidence rate of pediatric VTE was 0.19% (24/12,881). The venous thrombotic locations were deep venous thrombosis extremities (n = 18), superior vena cava (n = 1), cerebral sinovenous (n = 1), and other deep venous thrombosis (n = 4). Univariate analysis showed that age, weight, shock, sepsis, cancer and vasopressor receipt were statistically significant risk factors for pediatric VTE (all p ≤ 0.05). After multivariable logistic regression analysis, only shock (aOR: 6.77, 95%CI: 1.33–34.73, p = 0.019) and admission for sepsis (aOR: 6.09, 95%CI: 1.76–21.09, p = 0.004) were statistically significant associated with pediatric VTE. Conclusions In conclusion, data obtained from the Pediatric Intensive Care (PIC) database revealed a prevalence of VTE in pediatric patients of 0.19%. The most common location for venous thrombi was deep venous thrombosis (DVT) in the extremities. We identified that shock and sepsis were statistically significant factors associated with pediatric VTE.
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- 2024
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36. Pixel-to-Abundance Translation: Conditional Generative Adversarial Networks Based on Patch Transformer for Hyperspectral Unmixing
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Li Wang, Xiaohua Zhang, Jinhua Zhang, Hua Dong, Hongyun Meng, and Licheng Jiao
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Generative adversarial networks (GANs) ,hyperspectral unmixing (HSU) ,spatial-spectral information ,transformer ,Ocean engineering ,TC1501-1800 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Spectral unmixing is a significant challenge in hyperspectral image processing. Existing unmixing methods utilize prior knowledge about the abundance distribution to solve the regularization optimization problem, where the difficulty lies in choosing appropriate prior knowledge and solving the complex regularization optimization problem. To solve these problems, we propose a hyperspectral conditional generative adversarial network (HyperGAN) method as a generic unmixing framework based on the following assumption: The unmixing process from pixel to abundance can be regarded as a transformation of two modalities with an internal specific relationship. The proposed HyperGAN is composed of a generator and a discriminator, the former completes the modal conversion from mixed hyperspectral pixel patch to the abundance of corresponding endmember of the central pixel and the latter is used to distinguish whether the distribution and structure of generated abundance are the same as the true ones. In addition, we propose hyperspectral image (HSI) patch transformer as the main component of the generator, which utilizes adaptive attention score to capture the internal pixels correlation of the HSI patch and leverages the spatial-spectral information in a fine-grained way to achieve optimization of the unmixing process. Furthermore, we propose a data synthesis method based on superpixel segmentation and random split to get synthetic data with a spatial structure to further evaluate the effectiveness of our model for unmixing. Experiments on synthetic data and real hyperspectral data achieve impressive results compared with state-of-the-art competitors.
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- 2024
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37. MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization
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Yu Liu, Haiqiang Chen, Xuanxuan Yan, Jie Zhang, Zhenzhong Deng, Maosheng Huang, Jianchun Gu, and Jinhua Zhang
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MyD88 ,Nonalcoholic fatty liver disease ,Hepatocellular carcinoma ,Macrophage polarization ,CCL9/CCL15 ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver diseases and has emerged as the leading factor in the pathogenesis of hepatocellular carcinoma (HCC). MyD88 contributes to the development of HCC. However, the underlying mechanism by which MyD88 in myofibroblasts regulates NAFLD-associated liver cancer development remains unknown. Results Myofibroblast MyD88-deficient (SMAMyD88−/−) mice were protected from diet-induced obesity and developed fewer and smaller liver tumors. MyD88 deficiency in myofibroblasts attenuated macrophage M2 polarization and fat accumulation in HCC tissues. Mechanistically, MyD88 signaling in myofibroblasts enhanced CCL9 secretion, thereby promoting macrophage M2 polarization. This process may depend on the CCR1 receptor and STAT6/ PPARβ pathway. Furthermore, liver tumor growth was attenuated in mice treated with a CCR1 inhibitor. CCLl5 (homologous protein CCL9 in humans) expression was increased in myofibroblasts of HCC and was associated with shorter survival of patients with HCC. Thus, our results indicate that MyD88 in myofibroblasts promotes NAFLD-related HCC progression and may be a promising therapeutic target for HCC treatment. Conclusion This study demonstrates that MyD88 in myofibroblasts can promote nonalcoholic fatty liver disease-related hepatocarcinogenesis by enhancing macrophage M2 polarization, which might provide a potential molecular therapeutic target for HCC. Graphical Abstract
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- 2024
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38. Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
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Fuxin Ma, Shuyi Wu, Shiqi Li, Zhiwei Zeng, and Jinhua Zhang
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gastrointestinal hemorrhage ,risk factor ,predict ,meta-analysis ,Medicine - Abstract
Background/Aims There may be many predictors of anticoagulation-related gastrointestinal bleeding (GIB), but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systematic review to identify all risk factors for anticoagulant-associated GIB to inform risk prediction in the management of anticoagulation-related GIB. Methods A systematic review and meta-analysis were conducted to search PubMed, EMBASE, Web of Science, and Cochrane Library databases (from inception through January 21, 2022) using the following search terms: anticoagulants, heparin, warfarin, dabigatran, rivaroxaban, apixaban, DOACs, gastrointestinal hemorrhage, risk factors. According to inclusion and exclusion criteria, studies of risk factors for anticoagulation-related GIB were identified. Risk factors for anticoagulant-associated GIB were used as the outcome index of this review. Results We included 34 studies in our analysis. For anticoagulant-associated GIB, moderate-certainty evidence showed a probable association with older age, kidney disease, concomitant use of aspirin, concomitant use of the antiplatelet agent, heart failure, myocardial infarction, hematochezia, renal failure, coronary artery disease, helicobacter pylori infection, social risk factors, alcohol use, smoking, anemia, history of sleep apnea, chronic obstructive pulmonary disease, international normalized ratio (INR), obesity et al. Some of these factors are not included in current GIB risk prediction models. such as anemia, co-administration of gemfibrozil, co-administration of verapamil or diltiazem, INR, heart failure, myocardial infarction, etc. Conclusions The study found that anemia, co-administration of gemfibrozil, co-administration of verapamil or diltiazem, INR, heart failure, myocardial infarction et al. were associated with anticoagulation-related GIB, and these factors were not in the existing prediction models. This study informs risk prediction for anticoagulant-associated GIB, it also informs guidelines for GIB prevention and future research.
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- 2024
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39. Individual and combined degradation of N-heterocyclic compounds under sulfate radical-based advanced oxidation processes
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Mingxue Li, Zexiu An, Yanru Huo, Jinchan Jiang, Yuxin Zhou, Haijie Cao, Zhehui Jin, Ju Xie, Jinhua Zhan, and Maoxia He
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2022
40. Carbon-nitrogen conjugate-composited Cu
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Nianlu, Li, Mingquan, Zhu, Zhenyu, Feng, Wenhui, Lu, Jing, Chen, and Jinhua, Zhan
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Peroxidases ,Nitrogen ,Colorimetry ,Hydrogen Peroxide ,Glutathione ,Carbon ,Peroxidase - Abstract
In this work, cystine-glucose Maillard conjugates were composited with Cu
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- 2021
41. Insomnia and sleep duration for kidney function: Mendelian randomization study
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Yang Zhang, Zhaozhong Zhong, Zuofu Tang, Ruojiao Wang, Jiaqing Wu, Ning Na, and Jinhua Zhang
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Kidney function ,Mendelian randomization ,insomnia ,sleep duration ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objectives Extensive researches highlight the detrimental impact of sleep disorders such as insomnia and insufficient sleep duration on kidney function. However, establishing a clear causal relationship between insomnia, sleep duration, and kidney function remains challenging. This study aims to estimate this relationship using Mendelian randomization (MR).Methods Independent genetic variants strongly associated with insomnia (N = 462,341) and sleep duration (N = 460,099) were selected as instrumental variables from corresponding genome-wide association studies (GWAS). Kidney function parameters, including serum creatinine, estimated glomerular filtration rate by cystatin C (eGFRcys), acute renal failure (ARF), chronic renal failure (CRF), kidney injury molecule-1, neutrophil gelatinase associated lipocalin, microalbuminuria, cystatin C, and β2 microglobulin, were derived from GWAS databases. A two-sample MR study was conducted to assess the causal relationship between sleep disorders and kidney function, and multivariable MR was used to identify potential mediators. The inverse-variance weighted was used as the primary estimate.Results MR analysis found robust evidence indicating that insomnia and short sleep duration were associated with an increased risk of elevated serum creatinine, regardless of adjusting for obesity. Causal links between sleep duration and eGFRcys or cystatin C were also identified. While genetically predicted insomnia and sleep duration were found to potentially impact ARF, CRF, microalbuminuria, and β2 microglobulin, the p-values in multivariable MR analysis became nonsignificant. No pleiotropy was detected.Conclusions This study demonstrates a causal impact of insomnia on the risk of elevated serum creatinine and a positive effect of sleep duration on serum creatinine, eGFRcys, and cystatin C. Our findings also suggest their potential indirect effects on ARF, CRF, microalbuminuria, and β2 microglobulin mediated by obesity.
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- 2024
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42. Montmorillonite immobilized Fe/Ni bimetallic prepared by dry in-situ hydrogen reduction for the degradation of 4-Chlorophenlo
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Liying Ren, Cui Zhaojie, Shou-Qing Ni, Ning Yang, Vinothkumar Natarajan, Shuo-Shuo Zhang, Xuming Zhuang, Xiaohan Xin, Jinhua Zhan, and Hongyu Si
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Materials science ,Pollution remediation ,Hydrogen ,Scanning electron microscope ,Nanoparticle ,chemistry.chemical_element ,lcsh:Medicine ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Article ,Catalysis ,chemistry.chemical_compound ,Porous materials ,Reactivity (chemistry) ,lcsh:Science ,Bimetallic strip ,0105 earth and related environmental sciences ,Multidisciplinary ,lcsh:R ,021001 nanoscience & nanotechnology ,Nickel ,Montmorillonite ,chemistry ,Chemical engineering ,lcsh:Q ,0210 nano-technology - Abstract
This study puts forward a new way to produce montmorillonite immobilized bimetallic nickel-iron nanoparticles by dry in-situ hydrogen reduction method in the non-liquid environment, which effectively inhibits the oxidation of iron and nickel during the synthesis process and improves the reactivity of the material. The degradation of 4-Chlorophenol (4-CP) was investigated to examine the catalytic activity of the material. The morphology and crystal properties of the montmorillonite-templated Fe/Ni bimetallic particles were explored by using scanning electron microscopy, transmission electron microscopy, X-ray diffraction studies, and energy dispersive X-ray spectroscopy analysis. Results suggest that Fe and Ni particles were homogeneously dispersed on the montmorillonite. The optimization of Ni content and reduction temperature over the degradation of 4-CP was also studied. The introduction of Ni intensely improved the degradation of 4-CP and reached over 90% when Ni content was 28.5%. The degradation rate increased significantly with the increase of reduction temperature and showed maximum activity at the reduction tempreature of 800 °C. This study offers a new method to fabricate montmorillonite immobilized Fe/Ni bimetallic nanoparticles in the non-liquid environment and the composites exhibited high degradation activity to chlorinated organic compounds.
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- 2019
43. The magnetic biochar derived from banana peels as a persulfate activator for organic contaminants degradation
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Jinhua Zhan, Lingshuai Kong, Meng Xie, Long Ma, Vinothkumar Natarajan, and Xing Rong
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Bisphenol A ,General Chemical Engineering ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Persulfate ,01 natural sciences ,Nitrogen ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Reaction rate constant ,chemistry ,Biochar ,Environmental Chemistry ,0210 nano-technology ,Iron oxide nanoparticles ,BET theory ,Nuclear chemistry - Abstract
The magnetic biochar (γ-Fe2O3@BC) derived from banana peels was synthesized by a facile one-pot thermal process and used as the cost-effective and recyclable persulfate (PS) activator for organic contaminants degradation. The results showed that the encapsulated iron oxide nanoparticles not only introduced the magnetism into biochar for easy separation, but also influenced the catalytic ability for PS activation. The γ-Fe2O3@BC was found to be highly effective for bisphenol A (BPA) degradation without pH adjustment. A complete removal of BPA was obtained within 20 min with an observed rate constant (kobs) of 0.1849 min−1, which was almost two times as large as that (0.0956 min−1) of pure biochar. Further, it exhibited high mineralization efficiency for the degradation of various organic contaminants. The high catalytic activity could be attributed to large BET surface area, dispersed iron species, abundant oxygen functional groups and rich doped nitrogen. Radical quenching experiments and electron spin resonance (ESR) studies confirmed that OH , SO4 − and O2 − were all involved in the radical oxidation process which was responsible for BPA degradation. A mechanism of PS activation by the γ-Fe2O3@BC catalyst was proposed based on the synergistic effect of biochar and iron.
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- 2019
44. Efficient activation of persulfate decomposition by Cu2FeSnS4 nanomaterial for bisphenol A degradation: Kinetics, performance and mechanism studies
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Meng Xie, Long Ma, Jinhua Zhan, Yufeng Chen, Guodong Fang, Dongmei Zhou, Feng Zhu, and Lingshuai Kong
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Bisphenol A ,Quenching (fluorescence) ,Chemistry ,Process Chemistry and Technology ,Inorganic chemistry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Persulfate ,01 natural sciences ,Decomposition ,Catalysis ,0104 chemical sciences ,law.invention ,Electron transfer ,chemistry.chemical_compound ,X-ray photoelectron spectroscopy ,law ,0210 nano-technology ,Electron paramagnetic resonance ,General Environmental Science - Abstract
In this study, a flower-like Cu2FeSnS4 (CFTS) nanomaterial was applied to the activation of persulfate (PS) for the degradation of bisphenol A (BPA) in model industrial wastewater. The efficiency of PS decomposition by CFTS, and the mechanism of contaminant degradation by SO4 − were investigated. The results revealed that CFTS catalyzes PS decomposition more efficiently than the monometallic Cu/Fe/Sn sulfides and exhibits activity over a wide pH range. Electron spin resonance spectroscopy, X-ray photoelectron spectroscopy, and free radical quenching experiments revealed a tandem synergistic effect between Cu, Fe, and Sn in their quaternary chalcogenide systems upon PS activation. The intrinsic electron transfer between Cu, Fe and Sn, especially the Fe(II)* species formed upon the complexation of Fe(II) by S on the surface of the CFTS, overcomes the inhibition of the M(n+1)+/Mn+ redox cycle. CFTS shows promise as a catalyst for wastewater treatment.
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- 2019
45. Cobalt doped g-C3N4 activation of peroxymonosulfate for monochlorophenols degradation
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Jinhua Zhan, Feng Zhu, Junchuan Tang, Vinothkumar Natarajan, Lingshuai Kong, Wenhui Lu, and Meng Xie
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Sulfate radical ,General Chemical Engineering ,Radical ,Kinetics ,Doping ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,Catalysis ,Adsorption ,chemistry ,Environmental Chemistry ,Degradation (geology) ,0210 nano-technology ,Cobalt - Abstract
In this work, monochlorophenols (MCPs) isomers degradation was investigated by Co-doped g-C3N4 (CCN) using peroxymonosulfate (PMS) as the oxidant. The effects of the doping amount of Co, the concentration of PMS, the loading of catalyst and initial pH of the solution on the catalyst activity were systematically studied. The results showed that MCPs could be degraded effectively by CCN/PMS system. The degradation reaction followed pseudo-first order kinetics. Sulfate radical (SO4 −) was found as the major active radicals in the degradation process. MCPs were degraded effectively with the degradation rate order of 2-chlorophenol (2-CP) > 3-chlorophenol (3-CP) > 4-chlorophenol (4-CP). Except for the influence of structural characteristics of MCPs, this degradation rate order was also related to the adsorption behavior of CCN, which was based on the intermolecular interaction. Based on the analysis of the degradation products of MCPs, 1,4-benzoquinone or chlorinated 1,4-benzoquinone had been found to be the main intermediates.
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- 2019
46. Well-dispersed Pd nanoparticles on porous ZnO nanoplates via surface ion exchange for chlorobenzene-selective sensor
- Author
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Jinhua Zhan, Cuiling Gao, Zhenyu Feng, and Xicheng Ma
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Chemical substance ,Materials science ,Ion exchange ,General Chemical Engineering ,Oxide ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Nanomaterial-based catalyst ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,X-ray photoelectron spectroscopy ,Chemical engineering ,Chlorobenzene ,0210 nano-technology ,Selectivity - Abstract
The extensive use of chlorobenzene in chemical, pharmaceutical, and agrochemical industries poses a severe health hazard to human beings, because it is highly toxic. The detection of chlorobenzene by metal oxide gas sensors is difficult, owing to its chemically inert molecular structure. In this study, well-dispersed Pd nanoparticles were deposited on porous ZnO nanoplates via surface ion exchange, followed by H2 reduction. The preparation process effectively prevented the aggregation and uncontrollable growth of Pd particles. A gas-sensing test was conducted, and the modification of size-controlled Pd nanoparticles was found to effectively enhance the sensing properties of porous ZnO nanoplates to chlorobenzene over 300 °C (higher sensitivity at a low operating temperature). At 440 °C, 5% Pd@ZnO sensor showed a drastic increase in response by nearly 4.5-fold, as well as excellent sensing selectivity to chlorobenzene. Its repeatability and stability were acceptable. As known, Pd nanocatalysts contribute to the oxidation of chlorinated aromatic compounds. Pd@ZnO sensors generated more catalytic sites and oxygen species (confirmed by XPS), thus enhancing chlorobenzene oxidation and improving the sensitivity of ZnO-based gas sensors.
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- 2019
47. The pH-dependent contributions of radical species during the removal of aromatic acids and bases in light/chlorine systems
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Mingxue Li, Zhehui Jin, Jinhua Zhan, Zexiu An, Ju Xie, Yanru Huo, Maoxia He, Jinchan Jiang, and Yuxin Zhou
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General Chemical Engineering ,Radical ,Kinetics ,0207 environmental engineering ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,010501 environmental sciences ,01 natural sciences ,Medicinal chemistry ,Industrial and Manufacturing Engineering ,Dissociation (chemistry) ,chemistry.chemical_compound ,Reaction rate constant ,chemistry ,Chlorine ,Environmental Chemistry ,Degradation (geology) ,Acid–base reaction ,020701 environmental engineering ,0105 earth and related environmental sciences ,Benzoic acid - Abstract
The solar/chlorine and UV/chlorine systems as emerging advanced oxidation technologies (AOTs) are used for degrading trace organic contaminants (TrOCs) through generating various radical species. The pH is a vital parameter that significantly affects the degradation efficiency of contaminants. In this study, six aromatic acids and bases (AABs) are selected to investigate the pH-dependent degradation mechanisms and kinetics by two newly-discovered radicals (ClO• and BrO•). Among the 16 dissociation species, the structures with electron-rich rings possess stronger reactivities to ClO• and BrO• than those with electron-poor rings, which is similar to the result of HO•. However, ClO• and BrO• are considered to be more selective and pH-sensitive reacting with AABs than HO• based on the corresponding second-order rate constants (M−1 s−1). Compared with acidic pH, the basic pH could improve the degradation rate of most aromatics in both systems. As pH increases from 6 to 8, the contribution percentages of ClO• in terms of the removal of the aromatics (except for benzoic acid) in solar/chlorine rise more rapidly (from 0.33 ∼ 61.34% to 94.23 ∼ 99.09%) than those in UV/chlorine system (from 19.14 ∼ 99.60% to 96.75 ∼ 99.88%). The pH-dependent contributions of various radical species are attributed to structure-dependent reactivities of compounds and pH-dependent concentrations of radical species. As the dose of Br- increases from 0 to 10 μM, the contributions of BrO• to the removal of aromatics (except for benzoic acid) increase from 0% to 10.28 ∼ 19.32%, thanks to the increased [BrO•]ss. This work is necessary for enhancing the understanding of the pH-dependent contributions of individual species during the removal of dissociable aromatic contaminants in light/chlorine systems.
- Published
- 2022
48. Enhancing the Activity of Silver Nanowire Membranes by Electrochemical Cyclic Voltammetry as Highly Sensitive Flexible SERS Substrate for On-Site Analysis
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Yongchao Lai, Rui Zhang, and Jinhua Zhan
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nanostructures reconstitution ,Nanostructure ,Materials science ,General Chemical Engineering ,Nanoparticle ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Article ,lcsh:Chemistry ,chemistry.chemical_compound ,symbols.namesake ,General Materials Science ,Crystal violet ,Surface-enhanced Raman spectroscopy ,021001 nanoscience & nanotechnology ,silver nanowires ,surface-enhanced Raman spectroscopy ,cyclic voltammetry ,0104 chemical sciences ,Membrane ,lcsh:QD1-999 ,chemistry ,Chemical engineering ,swabbing extraction ,symbols ,Nanorod ,Cyclic voltammetry ,0210 nano-technology ,Raman spectroscopy - Abstract
The development of high-quality flexible surface-enhanced Raman spectroscopy (SERS) substrates is crucial for developing rapid SERS analysis in situ. Silver nanowire membranes as novel flexible substrates could benefit from the high collection efficiency of analytes by wrapping complex surfaces or wiping the surfaces of samples. However, their low SERS performance impedes further applications of silver nanowire membranes in analyte detection. Herein, we report an ultra-high-sensitivity silver nanowire membrane synthesized by a simple and time-saving cyclic voltammetry (CV) method. After CV treatment, a part of the silver nanowires on the silver nanowire membrane turned into small nanoparticles and nanorods. This nanostructure’s reconstitution increased the analytical enhancement factor of silver nanowire membranes by 14.4 times. Scanning and transmission electron microscopy, UV-vis spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy were employed to investigate the transformation in the membrane nanostructure. The CV-treated substrates exhibited high surface-enhanced Raman activity and good temporal stability. The limits of detection (LODs) for p-aminothiophenol, crystal violet, tetramethylthiuram disulfide, sodium perchlorate, malachite green, fluoranthene, and potassium nitrate are 3.7 × 10−12 M, 5.1 × 10−11 M, 5.4 × 10−11 M, 6.3 × 10−9 M, 0.00693 ng, 0.0810 ng, and 0.0273 ng on this substrate, respectively. Additionally, the developed substrate is feasible for the detection of crystal violet in real samples. These results certify that CV-treated substrates possess broad application prospects in on-site SERS analysis.
- Published
- 2021
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49. Acetaminophen degradation by hydroxyl and organic radicals in the peracetic acid-based advanced oxidation processes: Theoretical calculation and toxicity assessment
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Qiao Wang, Bo Wei, Qiong Mei, Mingxue Li, Zexiu An, Haijie Cao, Ju Xie, Chao Zhang, Jianfei Sun, Maoxia He, Wenxing Wang, and Jinhua Zhan
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Environmental Engineering ,Hydroxyl Radical ,Health, Toxicology and Mutagenesis ,Radical ,Kinetics ,Pollution ,Medicinal chemistry ,Hydroxylation ,Reaction rate ,chemistry.chemical_compound ,Aniline ,chemistry ,Peracetic acid ,Environmental Chemistry ,Degradation (geology) ,Reactivity (chemistry) ,Peracetic Acid ,Waste Management and Disposal ,Oxidation-Reduction ,Water Pollutants, Chemical ,Acetaminophen - Abstract
The research on the mechanisms and kinetics of radical oxidation in peracetic acid-based advanced oxidation processes was relatively limited. In this work, HO• and organic radicals mediated reactions of acetaminophen (ACT) were investigated, and the reactivities of important organic radicals (CH3COO• and CH3COOO•) were calculated. The results showed that initiated reaction rate constants of ACT are in the order: CH3COO• (5.44 × 1010 M−1 s−1) > HO• (7.07 × 109 M−1 s−1) > CH3O• (1.57 × 107 M−1 s−1) > CH3COOO• (3.65 × 105 M−1 s−1) >> •CH3 (5.17 × 102 M−1 s−1) > CH3C•O (1.17 × 102 M−1 s−1) > CH3OO• (11.80 M−1 s−1). HO•, CH3COO• and CH3COOO• play important roles in ACT degradation. CH3COO• is another important radical in the hydroxylation of aromatic compounds in addition to HO•. Reaction rate constants of CH3COO• and aromatic compounds are 1.40 × 106 – 6.25 × 1010 M−1 s−1 with addition as the dominant pathway. CH3COOO• has high reactivity to phenolate and aniline only among the studied aromatic compounds, and it was more selective than CH3COO•. CH3COO•-mediated hydroxylation of aromatic compounds could produce their hydroxylated products with higher toxicity.
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- 2021
50. Atmospheric ozonolysis of crotonaldehyde in the absence and presence of hydroxylated silica oligomer cluster adsorption
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Jinhua Zhan, Zhaoxu Qiu, Naixian Wang, Qiong Mei, Mingxue Li, Fenghua Wei, Xiaofei Bo, Maoxia He, Ju Xie, Jianfei Sun, Bo Wei, and Zexiu An
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Aldehydes ,Environmental Engineering ,Ozonolysis ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Nucleation ,General Medicine ,General Chemistry ,Photochemistry ,Silicon Dioxide ,Pollution ,Reaction rate ,chemistry.chemical_compound ,Reaction rate constant ,Adsorption ,Ozone ,chemistry ,Criegee intermediate ,Environmental Chemistry ,Ozonide ,Humans ,Crotonaldehyde - Abstract
As one of the main components of combustion of tobacco products occurs (CARB), crotonaldehyde has an acute toxicity and widely exists in the atmosphere, which is harmful to human health. The removal efficiency of VOCs by ozonation can reach 80–90%. Based on the theory of quantum chemistry, the degradation mechanism, kinetics and toxicity of crotonaldehyde by ozonation in gas phase and heterogeneous phase were studied. Ozone was added to the olefins unsaturated double bond to form a five-membered ring primary ozonide, which was further fractured due to its unstable structure to form a Criegee intermediate and an aldehyde compound. The reaction rate constant of crotonaldehyde with ozone was 1.24 × 10−17 cm3 molecule−1 s−1 at 298 K and 1 atm, which was an order of magnitude higher than the experimental value. From toxicity assessment, it was found that the ozonation of crotonaldehyde is beneficial to the removal of toxicity. Mineral dust aerosol exists in the atmosphere in large quantities, and SiO2 is the most abundant component. VOCs are transformed into particle state on their surface through homogeneous nucleation and heterogeneous nucleation. Referring to the crystal structure of SiO2, five hydroxylated silica oligomer cluster structures were simulated and the adsorption configurations of crotonaldehyde on their surface were simulated. The adsorption of crotonaldehyde on the surface of the clusters was achieved by forming hydrogen bonds and had good adsorption effects. The adsorption of hydroxylated silica oligomer clusters didn't change the ozonation mechanism of crotonldehyde, but had a certain effect on the reaction rate.
- Published
- 2021
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