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Synergistic ferroptosis-gemcitabine chemotherapy of the gemcitabine loaded carbonaceous nanozymes to enhance the treatment and magnetic resonance imaging monitoring of pancreatic cancer
- Source :
- Acta Biomaterialia. 142:284-297
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Pancreatic adenocarcinoma (PDAC) is one of the deadliest cancers, and it is resistant to most conventional antineoplastic therapies. To address this challenge, gemcitabine (Gem)-loaded carbonaceous nanoparticles (MFC-Gem) as nanozymes and a theranostic platform were fabricated and used for MR-guided ferroptosis-chemo synergetic therapy of PDAC. As a biocompatible carrier, MFC-Gem nanoparticles are regarded as peroxidase-like and glutathione peroxidase-like nanozymes that promote ferroptosis therapy by effectively generating ROS and consuming GSH. Meanwhile, the combination of MnFe
- Subjects :
- Glutathione Peroxidase
Biomedical Engineering
Antineoplastic Agents
General Medicine
Adenocarcinoma
Deoxycytidine
Magnetic Resonance Imaging
Gemcitabine
Biochemistry
Pancreatic Neoplasms
Biomaterials
Cell Line, Tumor
Ferroptosis
Humans
Reactive Oxygen Species
Molecular Biology
Peroxidase
Biotechnology
Subjects
Details
- ISSN :
- 17427061
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Acta Biomaterialia
- Accession number :
- edsair.doi.dedup.....d02bf60e3065275c5a5aa9e04035470b