1. Prediction model of platelet transfusion refractoriness in patients with hematological disorders
- Author
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Shuhan YUE, Xiulan HUANG, Yan ZENG, Qiao LEI, Mengzhen HE, Liqi LU, Shisong YOU, and Jingwei ZHANG
- Subjects
platelet transfusion refractoriness(ptr) ,risk factors ,prediction model ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Medicine - Abstract
Objective To explore the risk factors for platelet transfusion refractoriness(PTR)in patients with hematological disorders, construct a prediction model and validate the model efficacy. Methods Patients with hematological disorders who received platelet transfusion therapy in the Chengdu Second People′s Hospital from December 2021 to December 2022 were retrospectively included to judge the effectiveness of platelet transfusion and screened for risk factors by univariate and multivariate logistic regression. A prediction model for PTR was constructed using receiver operating characteristic(ROC) curve, calibration curve and decision curve(DCA) to assess the differentiation, calibration and clinical value of the model, respectively. Results A total of 334 hematological patients were included, including 168 males and 176 females, with a PTR incidence of 40.4%. Univariate and multivariate logistic regression analysis showed that platelet transfusion volume, erythrocyte transfusion volume, and neutrophil ratio were risk factors for PTR(P
- Published
- 2024
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