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Concrete made using recycled aggregates is a practical way to reduce construction waste. The purpose of this study is to improve the mechanical qualities of recycled aggregate concrete by incorporating waste fibers. The replacement rate of recycled coarse aggregate and volume content of waste fibers were planned as the study variables. The cubic compressive strength, splitting tensile strength, axial compressive strength, and elastic modulus were used to explore the mechanical characteristics of specimens. Additionally, the test results were optimized utilizing the response surface method, focusing on the influence of study variables on performance. The axial compressive constructive equation of waste fiber-reinforced recycled aggregate concrete was created based on the stress–strain curves of the specimens, and it serves as a foundation for further in-depth theoretical investigations.

The micro-mechanical properties and micro-structural characteristics of the interfacial transition zones of recycled concrete with graphene oxide were studied by using nanoindentor. The results showed that the average elastic modulus and width of the interfacial transition zone of recycled concrete with graphene oxide between new paste matrix and natural aggregate were about 20GPa and 30-35μm, respectively; The mean elastic modulus and transition zone width of the interfacial transition zone between new paste matrix and old paste matrix was about 35GPa and 25-30μm, respectively. By analyzing and calculating the probability distribution of hydration products, it was found that the graphene oxide template increased the proportion of calcium silicate hydrate in the hydrate and enhanced the content of calcium hydroxide crystal group. Compared with ordinary recycled concrete, the elastic modulus distribution in the interfacial transition zone was more uniform and the microstructure was more stable. It can be concluded that graphene oxide can enhance the mechanical properties and microstructure of the interfacial transition zone of recycled concrete so as to improve the macroscopic mechanical properties of recycled concrete.

Background Compensatory hyperhidrosis (CH) is a frequent side effect after sympathectomy for the treatment of primary palmar hyperhidrosis. We determined the effects of demographic and clinical factors which may increase the duration of CH (DCH). Methods One hundred twenty-two patients who had undergone sympathectomies from 2014 to 2016 were retrospectively reviewed. Anxiety was evaluated using the State and Trait Anxiety Inventory score. Follow-up evaluations continued until CH remitted. A Cox proportional hazards model was used to determine the association between DCH and variables. Results DCH ranged from 5 to 27 weeks (median, 11.47 weeks). Severe CH (HR = 0.318, 95% CI, 0.136–0.741) and exacerbated anxiety 1 month post-operatively (HR = 0.816, 95% CI, 0.746–0.893) may prolong CH. A positive correlation between post-operative anxiety and DCH was common in patients with moderate or severe CH, and in cases with forearm CH. Conclusions Pre- and post-operative anxiety should be evaluated, and anti-anxiety treatment is offered to patients with moderate-to-severe CH to shorten the DCH. Electronic supplementary material The online version of this article (10.1186/s13019-018-0736-3) contains supplementary material, which is available to authorized users.

Esophageal squamous cell carcinoma (ESCC) is the dominant subtype of esophageal cancer worldwide. This study aimed to explore the aberrant global expression profiling and construct regulatory network in ESCC for understanding tumorigenesis of ESCC. The expression pattern of long non-coding RNA (lncRNA), microRNA (miRNA) and mRNA was measured by RNA-sequencing in ESCC. Differentially expressed lncRNAs/miRNAs/mRNAs (DELs/DEMs/DEMIs) were identified in ESCC. DEMIs-DEMs network was constructed; hsa-miR-424-5p and hsa-miR-450b-5p were the hub miRNAs in the network, which negatively regulated 19 and 17 DEMs. DEMs targeted by DEMIs were significantly enriched in MAPK signaling pathway, pathways in cancer and focal adhesion signaling pathway. The expression of candidate DEMs and DEMIs in ESCC were validated through quantitative real-time polymerase chain reaction and microarray expression profiling analyses, and the results were generally consistent with our bioinformatics analysis. Our results might provide useful information for exploring the tumorigenesis mechanism and potentially therapeutic targets in ESCC.

// Xu-Rui Jin 1, * , Lu-Yao Zhu 1, * , Kai Qian 1 , Yong-Geng Feng 1 , Jing-Hai Zhou 1 , Ru-Wen Wang 1 , Li Bai 2 , Bo Deng 1 , Naixin Liang 3 , Qun-You Tan 1 1 Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China 2 Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China 3 Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China * These authors contributed equally to this work Correspondence to: Bo Deng, email: deng.bo@dphospital.tmmu.edu.cn Naixin Liang, email: pumchnelson@163.com Qun-You Tan, email: tanqy001@163.com Keywords: lung adenocarcinoma, circulating tumor cells, AIS, EMT Received: September 14, 2016 Accepted: February 08, 2017 Published: February 19, 2017 ABSTRACT Purpose: The study aimed to monitor circulating tumor cells (CTCs) in early stage lung adenocarcinoma patients. Results: CTCs were characterized and classified to epithelial (E-) CTCs, mesenchymal (M-) CTCs and epithelial- mesenchymal (E&M-) CTCs, as per epithelial-mesenchymal transition(EMT) biomarkers. CTCs could not be found in healthy controls. However, in cohort A, CTCs were found in 17 (17/18) cases. Detection rate of E-CTCs was lower (5/18) compared with M-CTC (10/18) or E&M-CTC (14/18). Highly abundant M-CTCs were prone to being in the tumors > 2 cm. In cohorts A and B, CTCs count increased significantly in all patients with tumor progression (7/7). Higher CTCs level or change range could be found postoperatively in the patients with tumor progression, as compared with patients with disease free survival ( P < 0.01). Additionally, CTCs detected by CanPatrol TM could be validated by CytoploRare or Pep@MNPs. Materials and Methods: We included four cohorts of patients and 20 healthy controls. In cohort A, CTCs were detected by a newly established approach, i.e., CanPatrol TM , prior to anesthesia and monitored after operation longitudinally. In cohort B, CTCs were not assessed prior to operation, but were longitudinally detected after operation. For validation, we detected FOLR(+)-CTCs by using CytoploRare and EPCAM(+)-CTCs by using Pep@MNPs prior to operation, in cohorts C and D, respectively. Conclusion: CTCs can be detected in early stage lung adenocarcinoma, even in adenocarcinoma in situ , and CTCs detection can effectively monitor tumor progression. The distinguishing of biomarkers of highly invasive and aggressive CTCs warrants further robust study.

The assessment of single gene such as ERCC1, TYMS, RRM1, TUBB3, EGFR, KRAS, BRAF, PIK3CA, ALK, and ROS1 is now widely applied in therapeutic decisions of non-small cell lung cancer (NSCLC). The aim of our study was to concurrently analyze these genes and evaluate their clinical significance in patients with NSCLC. Rearrangement of ALK and ROS1 was analyzed in 120 patients using FISH assays. Somatic mutation of EGFR, KRAS, BRAF, PIK3CA and mRNA expression of ERCC1, TYMS, RRM1, TUBB3, EGFR were examined by liquidchip platform in 350 patients . Data on clinical features were obtained from medical records of 119 patients, and the follow-up was conducted in 106 patients who received platinum-based adjuvant chemotherapy. We identified 5.0 % ALK rearrangements, 1.7 % ROS1 rearrangements, 36.6 % EGFR mutations, 8.9 % KRAS mutations, 0 % BRAF mutations, and 4.0 % PIK3CA mutations. Double or coexisting mutations were identified in 13 patients. Significant correlations were observed among EGFR, KRAS mutation, ERCC1, TYMS, RRM1, TUBB3, EGFR expression, and clinical features, especially histology (P

Background Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., CT-guided PTNB (Percutaneous Transthoracic Needle Biopsy), ENB (Electromagnetic Navigation Bronchoscopy), EBUS-TBNA (Endobroncheal Ultrasonography-Transbronchial Needle Aspiration), mediastinoscopy and CTC (Circulating Tumor Cell). Methods Medline and manual searches were performed. We identified the relevant studies, assessed study eligibility, evaluated methodological quality, and summarized diagnostic yields and complications regarding CT-guided PTNB (22 citations), ENB(31 citations), EBUS-TBNA(66 citations), Mediastinoscopy(15 citations) and CTC (19 citations), respectively. Results The overall sensitivity and specificity of CT-guided PTNB were reported to be 92.52% ± 3.14% and 97.98% ± 3.28%, respectively. The top two complications of CT-guided PTNB was pneumothorax (946/4170:22.69%) and hemorrhage (138/1949:7.08%). The detection rate of lung cancer by ENB increased gradually to 79.79% ± 15.34% with pneumothorax as the top one complication (86/1648:5.2%). Detection rate of EBUS-TBNA was 86.06% ± 9.70% with the top three complications, i.e., hemorrhage (53/8662:0.61%), pneumothorax (46/12432:0.37%) and infection (34/11250:0.30%). The detection rate of mediastinoscopy gradually increased to 92.77% ± 3.99% with .hoarseness as the refractory complication (4/2137:0.19%). Sensitivity and specificity of CTCs detection by using PCR (Polymerase Chain Reaction) were reported to be 78.81% ± 14.72% and 90.88% ± 0.53%, respectively. Conclusion The biopsy approaches should be chosen considering a variety of location and situation of lesions. CT-guided PTNB is effective to reach lung parenchyma, however, diagnostic accuracy and incidence of complications may be impacted by lesion size or needle path length. ENB has an advantage for biopsy of smaller and deeper lesions in lung parenchyma. ENB plus EBUS imaging can further improve the detection rate of lesion in lung parenchyma. EBUS-TBNA is relatively safer and mediastinoscopy provides more tissue acquisition and better diagnostic yield of 4R and 7th lymph node. CTC detection can be considered for adjuvant diagnosis.

Considering the actual factors such as axial compression ratio, constraint conditions and so on, We design 10 beam-column joints of different parameters under the condition of the same reinforcement ratio and use the monotonic loading type to study the influences of dosage of recycled aggregates and waste fibers, waste fiber length on beam-column joints on the ultimate bearing capacity of the core area. Experimental research shows that when the dosage of recycled aggregates is 50% , waste fiber content is 0.12%, waste fiber length is 19 mm, the node ultimate bearing core area best performance.

Through the ABAQUS software to simulate the compression performance of waste fiber recycled concrete column of the different fiber length and amount of fiber volume under the monotonic load, the ultimate carrying capacity and load - concrete strain curve of waste fiber recycled concrete eccentric compression column are concluded, and compare them with experimental results. The results show that the finite element analysis results and experimental results are basically in agreement with, which proves the feasibility and correctness of the finite element analysis.

// Bo Deng 1, * , Tianyu Sun 1, * , Bo Tang 1, * , Shaolin Tao 1 , Poming Kang 1 , Kai Qian 1 , Bin Jiang 1 , Kun Li 1 , Kunkun Li 1 , Jinghai Zhou 1 , Ruwen Wang 1 and Qunyou Tan 1 1 Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China * These authors have contributed equally to this work Correspondence to: Qunyou Tan, email: tanqy001@163.com Keywords: adenoviral p53 gene; non-small cell lung cancer; radical surgery; recurrence; metastasis Received: June 27, 2017 Accepted: September 20, 2017 Published: November 06, 2017 ABSTRACT Objective: To assess the efficacy of radical surgery combined with recombinant adenoviral human p53 (rAd-p53) gene therapy in treatment of resectable non-small cell lung cancer. Method: A total of 163 patients with resectable NSCLC meeting the inclusion criteria were randomly assigned to two groups: radical surgery alone (S) and radical surgery plus surgical wound surface injection of 2 x 10 12 rAd-p53 units (SP). All patients were followed up for at least 3 years for efficacy and safety. Study endpoints were loco-regional recurrence or distant metastasis (Rec-Met) rate as primary endpoints, and progression free survival (PFS), overall survival (OS) and safety assessments as secondary endpoints. Results: Recurrence or metastasis (Rec/Met) after surgery were 24/82 (29.27%) in SP group and 37/81 (45.68%) in S group. The difference in the Rec/Met rate was statistically significant (p = 0.0304) by chi-square test. The hazard ratios after adjusting of age and disease stage (S vs. SP) of PFS and OS are 1.772 (95% CI, 1.102 to 2.848) and 2.047 (95% CI, 1.109 to 3.377), respectively. The 3 years PFS and OS for SP vs. S were 71.9% vs. 46.9%, and 88.4% vs. 67.0%, respectively. Differences in PFS and OS between two treatment groups were significant with the p values of 0.0165 and 0.0191, respectively, using Log-Rank test. Conclusions: The wound surface injection of rAd-p53 showed efficacious effects in preventing recurrence or metastasis and improving PFS and OS after a radical surgery in patients with NSCLC.

Based on a large number of reference, by using non-linear FE analytical method to analyze the lightweight steel concrete horizontal bearing capacity. In order to obtain more accurate simulation results, using solid element to simulate the various components of the wall, between the concrete and the wall frame columns are connected by the binding manner. To limit the beam wall vertical wall planar degrees of freedom .The coupling beam at the loading point X direction freedom, which was calculated in the X direction. The analyzing result shows that the light steel structure is the main force members of the composite wall. And the increase of concrete strength can also improves the horizontal bearing capacity of the composite wall, but the concrete is not as the main bearing capacity of the component.

Using the finite element method to analysis the bearing capacity of light steel-foam concrete composite wall frame column under vertical load. Through the analysis of the bearing capacity of the wall frame columns filled with different grades of foamed concrete under the vertical load, the results of the effect of filled foamed concrete on the bearing capacity of light steel composite wall are obtained. Results show: 1) for the light steel structure with no foamed concrete, the spacing of the wall frame column is increased from 400mm to 600mm, and the axial load bearing capacity is reduced. 2) for the steel foam concrete filled with 12MPa foam concrete structure, the spacing of the wall frame column is increased from 400mm to 600mm, the axial bearing capacity decreases slightly. 3) when the strength of foam concrete is reduced to 8MPa, or increased to 24MPa, the spacing of the wall frame column increases from 400mm to 600mm, the axial bearing capacity decreases first and then increases.

The aim of this meta-analysis and systematic review of published evidence was to optimize chest tube management for fast-track rehabilitation of lung cancer patients after video-assisted thoracic surgery (VATS). The PubMed, Web of Science, and EMBASE databases were searched to identify all studies that addressed the issue of chest tube management after VATS for lung cancer. Finally, 35 articles were included for analysis, i.e., 29 randomized controlled trials and 6 clinical trials. After synthesis of the published evidence, the following protocol for chest tube drainage was formulated: (1) after VATS lung wedge resection, chest tube drainage can be omitted in selected cases; (2) normally, one 28Fr chest tube (or 19Fr Blake drain) is placed; (3) the use of a digital monitoring system is recommended; (4) in case of increasing pneumothorax or severe air leakage supported by digital recording system, the tube should be placed with active suction; and (5) the chest tube can be removed within 48 h postoperatively when air leakage is resolved and fluid drainage is

By means of ANSYS finite element software, the numerical model of ductile cast iron buried pipeline with flexible joint was established, and the entire model was comprised of pipeline and its exterior massive soil for simulating the coupling-interaction between soil and pipeline. Meanwhile, the multi-point excitation method was adopted for considering the wave-passage effect. According to EI-centro seismic wave record corresponding to III site, the stress-time-history curve of pipeline body and the displacement-time-history curve of flexible joint were obtained, as well as the most dangerous parts might occur leakage were indicated, which provides the reference to the optimal design of ductile cast iron buried pipeline with flexible joint.

Considering the actual factors such as axial compression ratio, constraint conditions and so on, We design 10 beam-column joints of different parameters under the condition of the same reinforcement ratio and use the monotonic loading type to study the influences of dosage of recycled aggregates and waste fibers, waste fiber length on beam-ends load-displacement relationships of beam-column nodes. Experimental research shows that when the dosage of recycled aggregates is 50% , waste fiber content is 0.12%, waste fiber length is 19 mm, beam-end bearing behaviour of node area is best.

Recent years, many infrastructures, say building structures and bridge structures, have suffered from multi-hazards. According to official reports, 286 fires broke out due to the 2011 off the Pacific coast of Tohoku Earthquake, and fire after 1995 Kobe earthquake destroyed almost 7000 buildings. Current design codes treat earthquakes, fires and explosions as completely independent. The application of multi-hazard design is essential for improving the safety of structures, reducing building life cycle costs and increasing efficiency. In this paper, some influential multi-hazard incidents are described primarily, and the state-of-the-art and research needs on multi-hazard design are presented.

At Present, stress corrosion and corrosion fatigue causing durability degradation of concrete structure in the field of civil engineering become an important problem,and thus become a hot topic to study. But the research on it at home and abroad is still in stage of theoretical exploration. This paper using self-designed corrosion fatigue loading test device, studied in magnesium nitrate solution of concrete under the action of erosion strength increasing regularity, results show that the concrete strength by corrosion fatigue than fatigue specimen attenuation extent.

In general, reinforced concrete frames have excellent fire resistance properties, but more and more concrete buildings collapsed in fires. The majority of past research work on the response of concrete building to fire has looked at the effects of fire upon individual structural members, and most commonly when subjected to heating from standard fire tests. At present, the fire behaviors of whole reinforced concrete frame are not adequately understood. There is a great need for development of models which consider the effects of fire on the whole structure under more realistic heating regimes. There is also a fundamental requirement for further large-scale testing of concrete structures, to observe the behavior of whole concrete structures in real fires and also for validation of advanced computer analysis tools. Accuracy and efficiency are two major concerns in finite element analysis of structural response of concrete frames in fires. In this paper, a multi-type finite elements hybrid model for simulating structural behavior of whole reinforced concrete frames in real fire is suggested.

This paper studies on the waste fiber strength test of 88 concrete beams crack , the beams section-dimension are 100mm×100mm and length 500mm. Research on recycled aggregate replacement ratio, the waste fiber length and incorporation, the crack height-ratio effect on fracture toughness of concrete. The result indicates that the waste fibers can effectively limit extension and perforation of crack of recycled aggregate, increasing the ductility of concrete, enhancing fracture properties of concrete and conducive to the improvement of fracture toughness of concrete.

In order to study the influence of the replacement ratio of recycled aggregate and the volume of waste fiber on the fracture performance of concrete, the three-point bending test is carried out on the waste fiber recycled concrete precast beams. Calculate the waste recycled fiber concrete fracture parameters according to the double-K fracture model. The results show that the fracture indexes of recycled fiber are related to the recycled aggregate replacement ratio and the volume content of waste fiber. The larger the replacement rate of recycled aggregate is, the smaller the fracture indexes of the specimens are. The volume content of waste fiber is 0.12%, which has the most significant effect on the fracture performance. The study shows that waste fiber can improve the fracture properties of recycled aggregate concrete.

On the foundation of the item that the residence flood controlled technique and standard tested and the analysis according to the formation of the sediment and the regulation of the sedimentation in the actual river. In the process of the studied item, design a kind of a new sedimentation basin in order to lower the sand carrying capacity of the down water in the limited distance and the biggest limit. Through the model experiment of this kind of the sedimentation basin and find out the result of the sink the sand under the different discharge, in order to guide the actual engineering application.

In Chinese rural areas, flooding is one of the most common and frequent natural disasters, which can cause terribly life and property losses partly due to heavily damage and collapse of rural buildings. Therefore, it is very urgent to conduct comprehensive study on failure mechanism of rural buildings under flood actions. In this paper, the failure mechanism of rural buildings in flood is studied, and protection strategies are summarized with emphasis on describing some new technology proposed by authors. The contents presented in this paper may be useful references for further study on flood damage to rural buildings and be helpful for Chinese government to develop correct flood mitigation policies.

As developing and integrating energy consumption detection system become more and more difficult, OPC technology is used to simplify the system. The integration of system can be improved largely and the development work can be decreased through OPC standard interface. Firstly, this paper introduces relative knowledge about OPC technology, and then realizes hardware and software development of energy consumption detection system in Shenyang large-scale public buildings. The result indicates that OPC can simplify system greatly and energy consumption data can be detected at real-time.

A model of attenuation of residual strength with number of cycles has been founded .In this model the constant confined stress and maximum stress of fatigue loading are both considered. Based on the data of experiment, the coefficients of the model are determined. The model can be used to predict the residual life of specimen under biaxial compressive loading with constant confined stress.

The low cycle loading tests of 3 pieces of recycled concrete latticed walls under different side column reinforcements and different axial pressure ratios are conducted. The failure mode, failure process, hysteresis curve, ductility, and energy dissipation of the walls are studied. The experiment results indicate that the failure mode of recycled concrete latticed wall under the cyclic load is shearing failure. It can enhance the ductility of the wall, distortion ability, and the earthquake resistance performance, with increasing the axial load ratio. It can enhance the ultimate load and restrain the crack development by increasing the reinforcement of the side columns.

Axial pullout test on ductile iron buried pipelines with MTS testing machine was carried out, the relation curve between axial tension and flexiable joint displacement was gotten, the functional failure mechanism of flexible joint of buried pipeline was discussed. The results indicate that there is relative displacement between pipe and soil under seismic action, meanwhile, the acting force between pipe and soil is the viscous damping force which is related to pipe-soil relative speed.

In the actual project, many concrete structures not only suffer the loading of static force and the repeated loading but also affected by the corrosive effects of chemical substances in external environment, which makes concrete corrosion and damage become an unavoidable issue in engineering. The research on it at home and abroad is still in stage of theoretical exploration. This paper studied the attenuation of the residual strength of concrete under fatigue loading and corrosion of chloride, using self-designed experimental corrosion fatigue loading device. The results show that the corrosion of concrete by chlorine ion is unneglected, its influence is greater than mathematical superposition of alternating load and corrosion when they affect the concrete separately.

The paper is from studying the flood experiment of the Town Housings’ structure form of the widespread existence,to explore the breakage mechanism of the town housing in flood,to guide the people how to improve the Town Housings’structure in the actuality and protect the people’s safety of the life and property.

At present, green energy saving idea, aimed at protecting environment and saving energy, now has become the guiding philosophy of modern architecture. Based on this, recycled carpet waste fibers for textile mechanical properties of concrete were discussed in this paper. The application of polypropylene fiber concrete abroad has been widely used, which is becoming more and more popularly in China recent years. Meanwhile, research on the application of recycled polypropylene fiber concrete is still scarce. The experiment of this paper adopt waste polypropylene fibers as reinforcing fiber, and we make the standard specimen which size is . We use the specimen to do the research of mechanical properties of compressive strength and observing the variation of compressive strength of concrete specimen in different fiber volume. We discovered that when we add volume of 0.12% recycled polypropylene fiber and the length is 19mm, the compressive strength of concrete increases greatly. We draw the conclusion that the compressive strength of recycled fiber concrete is better than ordinary one from the experiment. In addition, if such concrete was used widely, we may reach the goals of conserving resources and protecting the environment.

Many Marine environment or other corrosion in the concrete structure under the condition of fatigue cycle usually bear, thus make these components of fatigue and corrosion under coupling effect, thus speeding up the process of structure component, killing structure degradation of corrosion fatigue. This paper using self-designed corrosion fatigue loading test device, studied in sodium solution of concrete under the action of erosion strength increasing regularity, results show that the concrete strength by corrosion fatigue than fatigue specimen attenuation extent.

Polystyrene formwork of lattice concrete wall is a set of lightweight, insulation, sound insulation, fireproof, bearing multi-function in one of the "EPS new energy-saving" wall structure system. Through the polystyrene formwork structure forms of optimized improvement built in construction process of collapse produced high wall plate phenomenon. Do an axial compression ratio of 0.2 lattice specimens of reinforced concrete shear wall in axis pressure and reciprocating level forces test. The damage form of that wall for wall bottom beam-column central cross core ring crack and appear "X" type crack and are crushed. The mesh wall formed strong vertical limb and weak horizontal limb，belongs to the ductility structure , and has more yield , and energy dissipation capacity , and wall overall performance is strong , and avoid brittle failure , and has good ductility、deformation ability and bearing capacity of the characteristics of big .The finite element analysis and experimental results indicated that the ultimate bearing capacity of the wall are the same. For new formworks do wall by finite element analysis, in do not affect its aseismic capacity premise that wall structure forms are optimized design.

Through the seismic behavior of 4 pieces of concrete grill wall by pseudo- static test, the test sample destruction shape, the skeleton curves under to the different wall material and the different axial compression ratio, consuming energy ability, the ductility coefficient were conducted the contrast research. The experiment indicates the test sample under the level reciprocation load and the axial action of force, destruction shape main perform for cutting destruction; After wall dehiscence, the rigidity rate of descent is quick, after achieving the ultimate load, the rigidity drop flatten out, the wall has the good ductility. By enhancing the axial compression ratio, it may enhance the wall the ductility, to consume energy the coefficient; the walls contained recycled concrete aggregate has good energy dissipation and seismic performance

With the development of building energy-saving in China, energy performance contracting, a new energy management system is introduced. Through the analysis of current situation and trends based on domestic and international energy service industry, and also through the research of benefits sharing model between the Energy Service Company and its customers, the author establishes an energy efficiency sharing model, which contributes to the Energy Service Company to avoid operational risks, ensure its operating income, and finally promote the scientific development of energy industry. The advanced EPC model is of great importance in promoting the work of building energy in our country.

A model of attenuation of residual strength with number of cycles has been founded .In this model the constant confined stress and maximum stress of fatigue loading are both considered. 55 specimens of plain concrete are tested under biaxial compressive fatigue loading with constant confined stress. Based on the data of experiment, the coefficients of the model are determined. The residual strength attenuating curves are shown in the paper. The model can be used to predict the residual life of specimen under biaxial compressive loading with constant confined stress. The results of prediction show that the suggested method is better than the Miner rule.

Commonly used procedures for reconstructing hypopharyngeal and cervical esophageal defects resulting from total laryngopharyngectomy (TL) are the gastric conduit or colon transposition as well as microvascularized free flaps. Herein we designed an alternative procedure utilizing bilateral platysma myocutaneous flaps (PMCFs) for the reconstruction of hypopharyngeal and cervical esophageal defects. This report summarizes the technical description of this procedure. TL and cervical esophagectomy were performed and bilateral PMCFs were harvested for reconstruction of hypopharyngeal and cervical esophageal defects in 25 patients aged between 46 and 73 years (mean 58.7 ± 16.2 years). All these patients had advanced-stage (IV) cancer with involvement of the cervical esophagus. Operative time ranged from 176 to 382 minutes (average 243 ± 91 minutes) and the mean intraoperative blood loss was 294 ± 119mL. There were six cases of anastomotic leak (24.0%) and two of them (8.0%) developed anastomotic stricture. Neither flap necrosis nor postoperative death was observed. The majority of our patients (68.0%) were restored to a normal unrestricted oral diet after surgery. The 3-year and 5-year actuarial survival rates were approximately 54.7% and 26.1%, respectively. We conclude that reconstruction of the cervical esophagus with bilateral PMCFs is a valuable method for treating advanced hypopharyngeal carcinoma.

This study was designed to evaluate the clinical efficacy of pyloric digital fracture for the prevention of early delayed gastric emptying (DGE) after high-level esophagogastrostomy. From January 2004 to March 2009, we sequentially enrolled 78 patients after esophagogastrostomy: 48 patients with pyloric digital fracture (DF group) and 30 patients without any drainage procedure (non-DF group). Intraoperative manometric study was performed in 48 patients of the DF group. Postoperative evaluation was performed, including symptomatic questionnaire, radiographic study, and gastric scintigraphy. Intraoperative manometric study revealed that basal pyloric pressure and peak pressure of pylorus in phase III of the migrating motor complex increased significantly after gastric conduit was made and anastomosed, but decreased appreciably following digital fracture. Compared with the peak pressure of IPPW before digital fracture (88.52 ± 19.88 mmHg), it appreciably decreased following digital fracture (40.45 ± 13.52 mmHg). Occurrences of IPPW (in 10 min) and duration time of each occurrence (s) had similar trends for before and after digital fracture (11.5 ± 4.5 vs. 5.0 ± 3.5 and 7.0 ± 2.0 vs. 3.0 ± 1.0, respectively). Postoperative evaluation demonstrated that early DGE occurred in four patients in the non-DF group (13.3%), and there was no DGE patient in the DF group. There was significant difference regarding gastric scores between the DF group and the non-DF group (10.5 ± 3.4 vs. 16.7 ± 3.8, t = 2.8271, P

To establish bonding stress—slip constitutive model between bars and grout concrete, 13 test specimens were employed to study the bonding behavior and the force transfer of bars adhered to grout concrete. The bonding stress development of bars adhered to grout concrete was analyzed. The local bonding stress—slip curve was obtained. Based on the test results, a new bonding stress—slip constitutive model between bars and grout concrete was proposed. The results show that the maximum bonding stress is not influenced by the bar bond length, but it is strengthened when the splitting strength of grout concrete is increased. The model matches the experimental results well, and the regressing coefficient equals 1.7.

SUMMARY In this article, we reviewed our experience of treatment of the delayed intrathoracic nonmalignant esophageal perforation employing modified intraluminal esophageal stent. Between February 1990 and August 2006, eight patients were included in this study. Five patients experienced sepsis. The interval time between perforation and stent placement ranged from 36 h to 27 days (average, 8.6 days). Esophageal stenting and throracotomy for foreign body removal were performed in four patients. The remaining four patients underwent stent placement and thoracostomy. Nutrition was initiated through gastrostomy after 7 to 10 days after the stenting. The stent was removed after the patients resumed oral intake of food and the esophagogram showed that perforation was closed. There was no death in this group. Signs of sepsis remitted 1 week after stent placement. Complications included stress ulcer, stimulative cough, and pneumonia each. Stent removal ranged 32 to 120 days (average 66.7) after its placement. The stent was kept in place for 4 months to prevent formation of esophageal stricture in one patient with caustic esophageal burns. The follow-up was completed in all the patients. The mean follow-up period was 59 months (range 12–180). One patient with caustic esophageal burn underwent cicatricial esophagectomy and gastric transposition 3 years later due to the esophageal stricture. Barium swallow demonstrated that there was a diverticulum-like outpouching in one patient and slight esophageal stricture at T2 and T3 level in another. One patient developed reflux esophagitis 5 years after stent removal. All the patients finally had a normal intake of food. Modified esophageal stenting is an effective method to manage the delayed intrathoracic esophageal perforation. Prevention of stent migration and its convenient adjustment might be the major advantages of this method.

In this paper, for four groups of recycled concrete specimen in early shrinkage and re- straint cracking experiment, which the recycled aggregate replacement ratio of 100% and the waste fiber volume content of 0, 0.08%, 0.12%, 0.16%. Experimental results show that: when the volume content of waste fiber is 0.08%, the effect of reducing shrinkage is more obvious, while the volume content of waste fiber is 0.12%, the performance of anti-cracking is the best.

This paper studies small eccentric compression test of eight waste fiber recycled concrete columns with recycled coarse aggregate replacement ratio, waste fiber length, and waste fiber incorporation as parameters. The test is carried out on the failure mode and ductility of the waste fiber recycled concrete columns, which are also compared with those of the ordinary concrete column.

In lung cancer A549 cells, the present study evaluated the associations between p130cas expression and the activation of p38 or Smad2, which are components of two of the main signaling pathways of transforming growth factor-β1 (TGF-β1), i.e., epithelial-mesenchymal transition (EMT) and apoptosis, respectively. TGF-β1-induced EMT was investigated by inspecting cell shape and cell migration, and by testing E-Cadherin, N-Cadherin and Vimentin biomarkers in p130cas-RNA interference (RNAi)-A549 cells. The changes in TGF-β1-induced apoptosis, i.e., cleaved Caspase-3 levels, were additionally analyzed following p130cas-RNAi. p130cas-knockdown decreased the phosphorylated (p)-p38 expression level, and blockaded the TGF-β1-induced activation of p-p38 in the A549 cells. p130cas-knockdown arrested cell migration and impaired TGF-β1-induced EMT in the A549 cells, characterized by changes in cell morphology and biomarker levels. However, p130cas-knockdown had no impact on the activation of Smad2 and the cleavage of Caspase-3. These results indicate that p130cas is a novel molecular ‘rheostat’ that alters the function of the TGF-β1 signaling pathway from tumor suppression to tumor promotion in lung cancer cells. The underlying mechanism warrants further study.

We aim to optimize surgical strategy to decrease relapse of tubercular abscess in the chest wall (TACW).The records of 120 patients who underwent surgical treatment for TACW from May 2005 to March 2011 were retrospectively reviewed. We conducted the following surgical treatment as '6C + A' by abbreviating the first alphabet of each step: (i) careful exploration of the abscess; (ii) complete resection; (iii) cavity washing using sodium bicarbonate solution; (iv) coverage using muscle flap; (v) continuous suction and drainage; (vi) compression dressing and (vii) anti-tuberculosis medication.One hundred and thirteen cases were discharged for rehabilitation with the first stage wound healing (113/120). Four cases postoperatively suffered from subcutaneous fistula which was healed after dressing changes for 1-2 months. Three patients with an abscess relapse underwent the second operation 2 months after the first operation. Follow-ups ranged from 2 months to 6 years and demonstrated no recurrence.We deem the surgical procedures '6C + A' effective to obviate relapse of TACW.

Objective Our previous study suggested the potential clinical implications of BCAR1 in non-small-cell lung cancer (NSCLC) (Mol Diagn Ther. 2011. 15(1): 31–40). Herein, we aim to evaluate the predictive power of BCAR1 as a marker for poor prognosis in NSCLC cases, verify the carcinogenic roles of BCAR1 in the A549 lung adenocarcinoma cell line, and testify to the BCAR1/phospho-p38 axis. Methods Between January 2006 and June 2010, there were a total of 182 patients with NSCLC (151 cases with available follow up data, and 31 cases lost to follow-up due to the invalid contact information). We inspected BCAR1, phospho-BCAR1(Tyr410), phospho-p38(Thr180/Tyr182) and p38 expression in NSCLC tissues and matched adjacent normal tissues by immunoblotting and IHC. After BCAR1 -RNA interference in A549 cells, we inspected the protein expression (BCAR1, phospho-BCAR1, phospho-p38 and p38) and performed cell biology experiments (cell growth, migration and cycle). Results BCAR1 was overexpressed in NSCLC tissues (177/182) and cell lines (A549 and Calu-3). However, it was not detected in the normal adjacent tissue in 161 of the 182 cases. Higher BCAR1 levels were strongly associated with more poorly differentiated NSCLC and predicted poorer prognosis. BCAR1 knockdown caused cell growth arrest, cell migration inhibition and cell cycle arrest of A549 cells. Overexpression of BCAR1 was associated with activation of p38 in NSCLC cases, and BCAR1 knockdown caused reduction of phospho-p38 levels in A549 cells. Conclusion Overexpression of BCAR1 is a predictor of poor prognosis in NSCLC and plays important carcinogenic roles in carcinogenesis, probably via activation of p38 MAPK. However, further investigations are required immediately.