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Your search keyword '"Jimit Mehta"' showing total 2 results
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1. ChemInform Abstract: Pd-Catalyzed Amination as an Alternative to Nucleophilic Aromatic Substitution for the Synthesis of N-Alkyltacrines and Analogues

Author

Larry D. Williams, Jimit Mehta, Paul R. Carlier, and Ming Ma

Subjects
Primary (chemistry), Chemistry, Nucleophilic aromatic substitution, General Medicine, Medicinal chemistry, Amination, Catalysis
Abstract

A mild and convenient approach to the synthesis of title compounds (III) and (IX) is based on Pd-catalyzed amination of heteroaryl chlorides with primary amines.

Published
2011
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2. Pd-catalyzed amination as an alternative to nucleophilic aromatic substitution for the synthesis of N-alkyltacrines and analogues

Author

Larry D. Williams, Ming Ma, Jimit Mehta, and Paul R. Carlier

Subjects
Substitution reaction, Radical-nucleophilic aromatic substitution, Ligand, Chemistry, Nucleophilic aromatic substitution, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry, Amination, Article, Catalysis
Abstract

A reliable Pd-catalyzed amination protocol is described for the synthesis of N-alkyltacrines and analogues. The Josiphos ligand CyPFtBu was found to provide optimum yields: 16 examples are given. Compared to the typical high-temperature nucleophilic aromatic substitution (NAS) routes, Pd-catalyzed aminations proceed at significantly lower reaction temperatures, and enable the synthesis of otherwise inaccessible products.

Published
2011

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