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Resumen del poster presentado en el II Congreso de Investigación PTS. Granada, 9-11 febrero (2022)

Resumen del poster presentado en el II Congreso de Investigación PTS. Granada, 9-11 febrero (2022), Este trabajo ha sido financiado por los proyectos AGL2017-83772-R y P20_00242 del Ministerio de Ciencia e Innovación y Junta de Andalucía, respectivamente

Objetive: Type 2 diabetes mellitus (DM2) and osteoporosis are diseases associated with a pro‐inflammatory environment, the prevention of which through new therapeutic strategies could prevent their development. However, there are few studies that evaluate the inflammatory profile of osteoporosis in patients with DM2. This study focuses on evaluating the inflammatory immune response through serum concentrations of nine cytokines, two of them anti‐inflammatory (IL‐10, IL‐5) and six pro‐inflammatory (IL‐2, IL‐6, IL‐12 (p70), IL‐17A, TNFα and IFNγ) in 163 individuals with DM2 and 47 controls. A subpopulation, made up of 43 DM2 patients without osteoporosis, and 33 with osteoporosis, was analyzed in greater depth at the level of bone parameters. Furthermore, we have assessed the calciotropic hormones, bone remodeling markers, bone mineral density and vertebral fractures in the population, and we have analyzed the relationship of the cytokines tested with DM2, osteoporosis and prevalent vertebral fractures. Patients with DM2 had significantly higher serum concentrations of IL‐10 compared to the control group (0.5±1 vs. 0.14±0.3 pg/ml; p=0.016) and the levels of IL12 p70 were shown lower in patients with DM2 compared to controls (2.9±1.6 vs. 3.9±3.1 pg/ml; p=0.027). In the group of patients with DM2 and osteoporosis, the levels of the cytokine IL‐6 were elevated compared to the group with DM2 without osteoporosis (10.9±14.6 vs. 4.5±7.0; p=0.017). An association of IL‐5 was also observed, with its lowest levels in the DM2 group with osteoporosis (1.7±0.2 vs. 3.8±0.6; p=0.032). Furthermore, IL‐5 showed a direct correlation with the levels of the bone formation biomarker alkaline bone phosphatase (r=0.277, p=0.004) in the subpopulation of patients with DM2. The rest of cytokines did not show significant differences. In conclusion, our findings indicate that in our study population, patients with DM2 compared to healthy subjects present an inflammatory profile opposite to what is expected in a hyperglycemic situation, probably as a compensatory response to the inflammation caused. The cytokine profile is modified in the subpopulation of diabetic patients, depending on the presence of osteoporosis. In this case, the inflammatory profile in the presence of osteoporosis is consistent with the expected response., Este estudio ha sido financiado con las ayudas para realización de proyectos otorgadas por las fundaciones FEIOMM y SEEN, así como por el proyecto de la Consejería de Salud y familias PI-0450-2019. Además, el Dr. Jiménez-López agradece la financiación al programa de investigación Europeo Marie Curie (FP7--PEOPLE-2011-IOF, número de referencia PIOF-GA-2011-301550), así como al Ministerio de Economía, Industria y Competitividad por el proyecto del programa Ramón y Cajal (RYC-2014-16536) y el proyecto BFU2016-77243-P.

Editores: Jiménez-López, José Carlos (CSIC); Clemente, Alfonso (CSIC), This book is a collection of updated studies related to current improvements in legume traits and their agricultural benefits. It discusses the physiological functions, genetics, and genomics of legume crops. Chapters address such topics as genetics and biological insights of seed traits in the context of climate change, improving quality and yields of legume seeds, new genetic resources from diverse germplasms, and agricultural benefits of legumes in agroecosystems.

Comunicación oral presentada en: Microscopy at the Frontiers of Science 2021 (msf2021) on line. 29 septiembre a 1 octubre 2021. Braga, Portugal., This work was partially supported by ERDF co-funded research projects RTC-2017-6654-2 (MINECO), AT17_5247 and P18-RT-1577 (Junta de Andalucía), and FGCCLG‐2021‐0015 from Fundación General del CSIC (Cuenta la Ciencia Program). The authors appreciate the support of JC Jimenez-Lopez, A Zafra, E Lima, AJ Castro, A Rodríguez and DF Nicolás from EEZ, Carlos de la Fuente Sáez (IES Miguel de Cervantes, Murcia, Spain, and the Confocal and Transmission Electron Microscopy (CTEM) facility of the EEZ Institute. Special thanks to the “Red Murciana de Semillas” for providing local varieties.

Resumen del poster presentado en: X Food Technology International Symposium. Murcia, 17-18 mayo (2021) on line, This research work has been funded by The European Research Program MARIE CURIE (FP7-PEOPLE-2011-IOF), Grant Ref.: PIOF-GA-2011-30155; The Spanish Ministry of Economy, Industry and Competitiveness (MINECO), grant ref.: RYC-2014-16536 (RAMON y CAJAL Research Program) and grant ref.: BFU2016-77243-P.

Resumen del poster presentado en: Congreso en red de Olivicultura, Citricultura y Fruticultura de la Sociedad Española de Ciencias Hortícolas. 23-25 marzo (2021) On line., Este trabajo ha sido financiado por los proyectos financiados parcialmente con fondos FEDER: CA8313, P18-RT-1577 (Junta de Andalucía), RTC-2016-4824-2, RTC-2017-6654-2 (Programa Retos-Colaboración); 09021200008 (contrato de apoyo tecnológico CSIC), BFU2016-77243-P, PID2020-113324GB-100 (Plan Nacional I+D), RYC-2014-16536 (Programa Ramón y Cajal) y un programa de Cooperación Bilateral CONICET-CSIC y la Secretaría de Ciencia y Tecnología de la Universidad Nacional de Córdoba (SeCyT-UNC).

Resumen del poster presentado en: Congreso en red de Olivicultura, Citricultura y Fruticultura de la Sociedad Española de Ciencias Hortícolas. 23-25 marzo (2021) On line., Financiado parcialmente con fondos FEDER: CA8313, P18-RT-1577 (Junta de Andalucía), RTC-2017-6654-2 (Programa Retos-Colaboración); 09021200008 (contrato de apoyo tecnológico CSIC), PID2020-113324GB-100 (Plan Nacional I+D), y RYC-2014-16536 (Programa Ramón y Cajal).

Editores: Jiménez-López, José Carlos (CSIC); Clemente, Alfonso (CSIC)

Editado por Jiménez-López, José Carlos (CSIC)

Conferencia invitada en el: 10th Conference Polish Society of Experimental Plant Biology." Experimental plant biology at various scales: from molecules to environmental. Katowice, Polonia. 20-21 septiembre (2021), This study was supported by ERDF-co-funded projects. CA8313, P18-RT-1577 (Junta de Andalucía), RTC-2016-4824-2, RTC-2017-6654-2 (Programa Retos-Colaboración); 09021200008 (contrato de apoyo tecnológico CSIC), BFU2016-77243-P, PID2020-113324GB-100 (Plan Nacional I+D). AZ thanks the JAECSIC program and the Agrifood Campus of International Excellence ceiA3 for the grant funding kindly provided.

1 página .- Presentación oral en el 25th National Symposium for Applied Biological Sciences (NSABS). Celebrado en Gembloux, Belgica. 31 enero 2020, European Research Program MARIE CURIE (FP7-PEOPLE-2011-IOF) grant number PIOF-GA-2011-30155; the Spanish MINECO grants numbers RYC-2014-16536 (Ramon y Cajal Research Program) and BFU2016-77243-P; the CSIC-Intramural grant number 201540E065

Legumes are major ingredients in the Mediterranean diet, playing an essential role in developing countries. Grain legumes, such as lentil, chickpea, pea, lupin and beans, among others, are recognized as good sources of proteins, starch, fiber, vitamins and minerals for human nutrition, being an essential food crop for people worldwide. Due to their nutritional and techno-functional properties, legumes are widely used by the food industry as ingredients in a wide range of products for general and specific groups of the population, including vegetarians, diabetics or celiac patients. The Special Issue “Legumes as Food Ingredients: Characterization, Processing, and Applications” covers key aspects regarding the nutritional quality of legume flours and their derived products, as well as the health benefits of some of their bioactive components. The amounts of antinutritional components, such as certain allergens that might pose risks to sensitized consumers, are reported to be reduced by processing. Several pretreatments, including fermentation with lactic bacteria and yeasts, are used to improve the nutritional and sensory profile of the legume-derived products, increasing their acceptance by consumers. This research received no external funding

Lupinus angustifolius or narrow-leafed lupin (NLL) is an important Pulse world-wide and an outstanding alternative source of high quality proteins. NLL ß-conglutin (vicilin or 7S acid globulin), a multigene family of proteins, is the main representative protein in NLL seeds exhibiting multifunctional properties and benefits recently discovered. These functions may result from specific structural features of NLL ß-conglutins in comparison with most legume vicilin proteins. From the agricultural side, NLL ß-conglutin proteins (1a) exert antifungal properties promoting enhanced plant resistance to necrotrophic oomycete pathogens and (1b) displaying functional interplay between storage protein mobilization and seed oxidative metabolism as a functional regulatory and signalling crossroad for the control of physiological underlying processes of the seed dormancy breakage and release, during germination, and seedling growth. NLL ß-conglutins benefits go beyond nutritional properties because displayed nutraceutical functions make them an outstanding source of innovative ingredients for functional food. They have antioxidant activity and anti-inflammatory properties, which are able to improve inflammatory-related diseases such as type 2 diabetes through (a) regulation of insulin signalling pathway, (b) improving insulin sensitivity, (c) facilitating glucose uptake by cells, (d) together with their capacity for balancing the oxidative homeostasis, metabolic, and signalling pathways (e) while reducing reactive oxygen specie production and increase cellular oxidative defence capacity. Interestingly, NLL ß-conglutins also display anti-nutritional properties as proteins capable to elicit allergic responses in sensitized individuals. This review outlines newly discovered knowledge of the narrow-leafed lupin ß-conglutin proteins drawing on information gained from structure-functional properties, agriculture benefits, as well as nutraceutics and molecular allergy point of views Consejo Superior de Investigaciones Científicas, Grant/Award Number: 201540E065; Ministerio de Economía, Industria y Competitividad, Gobierno de España, Grant/Award Numbers:BFU2016-77243-P, Ramón y Cajal, RYC-2014-16536; European Research Program MARIE CURIE (FP7-PEOPLE-2011-IOF), Grant/Award Number: PIOF-GA-2011-3015

1 página de abstract y Poster presentado en IV Congreso Nacional de Jóvenes Investigadores en Biomedicina (IV National Congress of Young Researchers in Biomedicine) Celebrado en Granada, España. 4-6 nov 2020, Supported by European Research Program MARIE CURIE (FP7-PEOPLE-2011-IOF), Project ref.: PIOF-GA-2011-301550; by the Spanish Government (MINECO), project ref.: RYC-2014-16536 (Research Program Ramon y Cajal), and project ref.: BFU2016- 77243-P; and by CSIC – Intramural project, Ref: 201540E065

1 página.- Presentacion oral en el 25th National Symposium for Applied Biological Sciences (NSABS). Celebrado en Gembloux, Belgica. 31 enero 2020, European Research Program MARIE CURIE (FP7-PEOPLE-2011-IOF), Project ref.: PIOFGA2011-301550; The Spanish Government (MINECO), project ref.: RYC-2014-16536 (Ramon y Cajal Research Program); and project ref.: BFU2016-77243-P; CSIC – Intramural project ref.: 201540E065; and Institute of Health Carlos III, project ref.: PIE16/00045 (ISCIII).

Resumen de la comunicación y poster completo presentado en el Spanish-Portuguese meeting for advanced optical microscopy (SPAOM2019). Celebrado en Coimbra (Portugal) 6-8 Nov, US Department of Energy grant ref. DE-FG02-04ER15526; Spanish MINECO grant ref. RYC-2014-16536 (Ramon y Cajal Research Program) and BFU2016-77243-P.