63 results on '"Jill J. Colglazier"'
Search Results
2. Thirty-three-year-old man with circumflex aorta and 4-cm right subclavian artery aneurysm
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Jill J. Colglazier, MD, Bianca Kenyon, MD, Eduardo Danduch, MD, and Alberto Pochettino, MD
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Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2022
- Full Text
- View/download PDF
3. A case of a large leiomyomatous uterus with multiple arteriovenous malformations and subsequent high cardiac output state with severe four chamber cardiac enlargement
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Beatriz Vega, Andrew H. Stockland, Rachel M. Bramblet, Alexandra L. Anderson, Rekha Mankad, Zaraq Khan, Mohamed Mustafa, Joan M. Steyermark, Amanda R. Fields, Novette J. Berntson, J. Kenneth Schoolmeester, Jill J. Colglazier, and Jamie N. Bakkum-Gamez
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Uterine arteriovenous malformation ,Leiomyoma ,Fibroid ,Uterine artery embolization ,Fumarate hydratase deficiency ,Gynecology and obstetrics ,RG1-991 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Uterine arteriovenous malformations (AVMs) are rare and potentially life-threatening. They can be congenital or acquired. Uterine artery embolization or hysterectomy are considered mainstays of management. AVMs can be associated with leiomyomas, and patients may require both procedures. We present a case of a 42-year-old woman with a massively enlarged leiomyomatous uterus supplied and drained by multiple large AVMs, leading to high cardiac output state with severe four chamber cardiac dilation. Management required a multidisciplinary team of interventional radiology, gynecologic oncology surgery, vascular surgery, cardiac anesthesiology, cardiology, and urology and a 2-day interventional approach of preoperative arterial embolization followed by hysterectomy.
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- 2021
- Full Text
- View/download PDF
4. Midterm Clinical Outcomes of Retrograde Open Mesenteric Stenting for Mesenteric Ischemia
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Nolan C. Cirillo-Penn, Randall R. DeMartino, Todd E. Rasmussen, Fahad Shuja, Jill J. Colglazier, Manju Kalra, Gustavo S. Oderich, and Bernardo C. Mendes
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Retrograde open mesenteric stenting (ROMS) has become a mainstay in treatment of mesenteric ischemia; however, follow-up in contemporary studies is limited.A single-center retrospective review of patients undergoing ROMS from 2007 to 2020 was conducted. Demographics, presentation, and procedural details were reviewed. End points were morbidity and mortality, technical success, primary patency, reinterventions, and freedom from clinical recurrence.ROMS was performed in 34 patients, 19 female (56%). Mean age was 71 ± 10 years. Eighteen patients (53%) presented with acute mesenteric ischemia (AMI), 11 (32%) with acute-on-chronic, and 5 (15%) with chronic mesenteric ischemia. Etiology was chronic atherosclerosis with/without in-situ thrombosis in 28 patients (82%), superior mesenteric artery dissection in 3, and 1 each with embolic, vasculitic, and nonocclusive ischemia. Four patients (12%) had prior mesenteric procedures (3 Celiac/1 superior mesenteric artery stent) and 1 had unsuccessful transbrachial stenting attempt. Technical success, defined as successful stenting through a retrograde approach was attained in 31 patients (91%), with the 3 remaining patients treated with transbrachial stenting in 2 and iliomesenteric bypass in 1. Covered stents were used in 21 patients (64%) with or without stent extension with bare-metal stents. Eight patients (23%) required thromboembolectomy and 9 (26%) underwent patch angioplasty. Thirty-day mortality rate was 35%, all in patients with AMI (10) or acute-on-chronic (2). Eighteen patients (53%) underwent bowel resection, all presenting acutely. Early reinterventions within the first 30 days were required in 5 patients (15%), including 2 redo ROMS with thrombectomy and endarterectomy, 2 percutaneous stent extensions, and 1 aortic septum fenestration with coiling of a jejunal branch pseudoaneurysm. With a median follow-up of 3.7 (interquartile range: 0.8-5.0) years, in patients surviving discharge, 5 required reintervention yielding freedom from reintervention rates of 87% at 1 year and 71% at 3 years. All postdischarge reinterventions were endovascular with no conversion to bypass. The overall 1-year and 3-year primary patency rates were 70% and 61% (primary-assisted patency at 1 and 3 years was 87% and secondary patency at 1 and 3 years was 97%). The freedom from symptom recurrence was 95% at 1 and 3 years.ROMS carries high rates of technical success in patients with mesenteric ischemia, despite a high chronic atherosclerotic burden. Although mid-term patency rates are acceptable, AMI is still associated with high early morbidity and mortality, with high rates of associated bowel resection. ROMS is a valuable tool in the armamentarium of vascular surgeons.
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- 2023
5. An Analysis of Malpractice Litigation of Vascular Surgeons in Cases Involving Aortic Pathologies
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Indrani Sen, Asad Choudhry, Sai Kiran Cherukuri, Bernardo C. Mendes, Jill J. Colglazier, Fahad Shuja, Randall R. DeMartino, Todd E. Rasmussen, and Manju Kalra
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Objective The aim of this study was to analyze malpractice claims for aortic pathologies and to assess if there has been a change in rate of malpractice lawsuits with evolution of endovascular therapy. Methods Malpractice lawsuits were individually screened and compiled from the Westlaw database from 2000 to 2017 through use of relevant search terms. Data were collected of allegations, diagnoses, and outcomes of each case and compared. Results 268 unique cases were included in this study, with aneurysms (54%, n = 145) and dissection (35%, n = 94) making up the majority. There was a defendant verdict in 53% (n = 141), plaintiff verdict in 24% (n = 65), and settlements in 23% (n = 62) of lawsuits. Litigation was higher in the Midwest and Northeast. There was a gradual decline in litigation overall, however endovascular case numbers remained constant. There was negligible difference in the primary allegation underlying the litigation for various aortic pathologies, time to litigation and award between open and endovascular procedures. Conclusion The proportion of litigation for clinical negligence in endovascular cases amongst all vascular surgical lawsuits is increasing. As novel methods of endovascular therapy emerge, it is imperative that physicians remain vigilant to legal considerations to minimize malpractice risk.
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- 2022
6. Patency rates of hepatic arterial resection and revascularization in locally advanced pancreatic cancer
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Roberto Alva-Ruiz, Amro M. Abdelrahman, Patrick P. Starlinger, Jennifer A. Yonkus, David N. Moravec, Joel J. Busch, Chad J. Fleming, James C. Andrews, Bernardo C. Mendes, Jill J. Colglazier, Rory L. Smoot, Sean P. Cleary, David M. Nagorney, Michael L. Kendrick, and Mark J. Truty
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Pancreatic Neoplasms ,Hepatic Artery ,Treatment Outcome ,Pancreatectomy ,Hepatology ,Portal Vein ,Gastroenterology ,Humans ,Arterial Occlusive Diseases ,Adenocarcinoma ,Retrospective Studies - Abstract
Arterial resection (AR) for pancreatic adenocarcinoma is increasingly considered at specialized centers. We aimed to examine the incidence, risk factors, and outcomes of hepatic artery (HA) occlusion after revascularization.We included patients undergoing HA resection with interposition graft (IG) or primary end-to-end anastomoses (EE). Complete arterial occlusion (CAO) was defined as "early" (EO) or "late" (LO) before/after 90 days respectively. Kaplan-Meier and change-point analysis for CAO was performed.HA resection was performed in 108 patients, IG in 61% (66/108) and EE in 39% (42/108). An equal proportion (50%) underwent HA resection alone or in combination with celiac and/or superior mesenteric artery. CAO was identified in 18% of patients (19/108) with arterial IG least likely to occlude (p=0.019). Hepatic complications occurred in 42% (45/108) and correlated with CAO, symptomatic patients, venous resection, and postoperative portal venous patency. CAO-related operative mortality was 4.6% and significantly higher in EO vs LO (p = 0.046). Median CAO occlusion was 126 days. With change-point analysis, CAO was minimal beyond postoperative day 158.CAO can occur in up to 18% of patients and the first 5-month post-operative period is critical for surveillance. LO is associated with better outcomes compared to EO unless there is inadequate portal venous inflow.
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- 2022
7. Incidence, Re-intervention and Survival Associated with Type II Endoleak at Hospital Discharge after Elective EVAR in the Vascular Quality Initiative
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Randall R. DeMartino, Matthew D. Breite, Dan Neal, Bernardo C. Mendes, Jill J. Colglazier, David.H. Stone, and Salvatore T. Scali
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
8. International Multi-Institutional Experience with Presentation and Management of Aortic Arch Laterality in Aberrant Subclavian Artery and Kommerell’s Diverticulum
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Clare Moffatt, Jonathan Bath, Richard T. Rogers, Jill J. Colglazier, Drew J. Braet, Dawn M. Coleman, Salvatore T. Scali, Martin R. Back, Gregory A. Magee, Anastasia Plotkin, Philip Dueppers, Alexander Zimmermann, Rana O. Afifi, Sophia Khan, Devin Zarkowsky, Gregory Dyba, Michael C. Soult, Kevin Mani, Anders Wanhainen, Carlo Setacci, Massimo Lenti, Loay S. Kabbani, Mitchell R. Weaver, Daniele Bissacco, Santi Trimarchi, Jordan B. Stoecker, Grace J. Wang, Zoltan Szeberin, Eniko Pomozi, Hugh A. Gelabert, Shahed Tish, Andrew W. Hoel, Nicholas S. Cortolillo, Emily L. Spangler, Marc A. Passman, Giovanni De Caridi, Filippo Benedetto, Wei Zhou, Yousef Abuhakmeh, Daniel H. Newton, Christopher M. Liu, Giovanni Tinelli, Yamume Tshomba, Airi Katoh, Sammy S. Siada, Manar Khashram, Sinead Gormley MBBCH, John R. Mullins, Zachary C. Schmittling, Thomas S. Maldonado, Amani D. Politano, Pawel Rynio, Arkadiusz Kazimierczak, Alexander Gombert, Houman Jalaie, Paolo Spath, Enrico Gallitto, Martin Czerny, Tim Berger, Mark G. Davies, Francesco Stilo, Nunzio Montelione, Luca Mezzetto, Gian Franco Veraldi, Mario D'Oria, Sandro Lepidi, Peter Lawrence, and Karen Woo
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
9. The USMLE® STEP 1 Pass or Fail Era of the Vascular Surgery Residency Application Process: Implications for Structural Bias and Recommendations
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Khaled I. Alnahhal, Sean P. Lyden, Francis J. Caputo, Ahmed A. Sorour, Vincent L. Rowe, Jill J. Colglazier, Brigitte K. Smith, Murray L. Shames, and Lee Kirksey
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
10. Outcomes of Unilateral Versus Bilateral Use of the Iliac Branch Endoprosthesis for Elective Endovascular Treatment of Aorto-iliac Aneurysms
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Mario D’Oria, Emanuel R. Tenorio, Gustavo S. Oderich, Randall R. DeMartino, Manju Kalra, Fahad Shuja, Jill J. Colglazier, and Bernardo C. Mendes
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2022
11. Outcomes of Endovascular Interventions for Popliteal Artery Atherosclerotic Disease
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Armin Tabiei, Sebastian Cifuentes, Randall R. DeMartino, Manju Kalra, Jill J. Colglazier, Bernardo C. Mendes, Todd E. Rasmussen, Jonathan Morrison, Robert Vierkant, and Fahad Shuja
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
12. Characterization and Surgical Management of the Aberrant Subclavian Artery
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Tiziano Tallarita, Richard T. Rogers, Thomas C. Bower, William Stone, Houssam Farres, Samuel R. Money, and Jill J. Colglazier
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Surgery ,Cardiology and Cardiovascular Medicine - Abstract
Aberrant subclavian arteries (aSCA), with or without aortic pathology are uncommon. The purpose of this study is to review our experience with surgical management of aSCA.We performed a retrospective review of patients who underwent surgery for aSCA between 1996-2020. Symptomatic and asymptomatic patients were included. Primary endpoints were ≤ 30 day and late mortality. Secondary endpoints were ≤ 30-day complications, graft patency, and re-interventions.Forty-six symptomatic and 3 asymptomatic patients with aSCA underwent surgical treatment (female: 31, 62%; median age 45 years). Aberrant right subclavian artery (aRSCA) was present in 38 (78%), and aberrant left subclavian artery (aLSCA) in 11 (22%). Forty-one (84%) had a Kommerell diverticulum (KD) and 11(22%) had concomitant distal arch or proximal descending thoracic aortic (DA/PDTA) aneurysm. Symptoms included dysphagia (56%), dyspnea (27%), odynophagia in (20%), and upper extremity exertional fatigue in (16%). Five patients (10%) required emergency surgery. The aSCA was treated by transposition in 32, carotid to subclavian bypass in 11 and ascending aorta to subclavian bypass in 6. KD was treated by resection and oversewing in 19 (39%). Fifteen (31%) required DA/PDTA replacement for concomitant aortic disease and/or KD treatment. TEVAR was used to exclude the KD in 6 (12%). Seven patients (14%) had only bypass or transposition. 30-day complications included one death from pulseless electrical activity arrest secondary to massive pulmonary embolism. 30-day major complications (14%) included acute respiratory failure in 3, early mortality in 1, stroke in 1, NSTEMI in 1, and 1 temporary dialysis in 1. Others included 5 (10%) chylothorax/lymphocele, 2 (4%) acute kidney injury (AKI), 2 (4%) pneumonia, 2 (4%) wound infection, 2 (4%) atrial fibrillation, 2 (4%) Horner syndrome, 1 (2%) lower extremity acute limb ischemia (ALI) and 1 (2%) left recurrent laryngeal nerve injury. At median follow up of 53 months (range 1-230), 40 (80%) patients had complete symptom relief and 10 (20%) had improvement. Six late deaths occurred at a median of 157 months and were not procedure or aortic related. Primary patency was 98%. ≤ 30-day re-interventions occurred in 2 (4%) for ligation of lymphatics and bilateral lower extremity fasciotomy after proximal DTA replacement. One patient required late explant of an infected and occluded carotid to subclavian bypass graft; treated by cryopreserved allograft replacement.Surgical treatment of the aSCA can be accomplished with low major morbidity and mortality with excellent primary patency and symptom relief.
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- 2022
13. Adjunctive Hemostatic And Resuscitative Techniques To Facilitate Hemipelvectomy For Parkes-Weber Syndrome
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Claire E. Cassianni, Peter S. Rose, Nolan C. Cirillo-Penn, Stephanie F. Heller, Waleed Gibreel, and Jill J. Colglazier
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
14. Women Have a Lower Rate of Abdominal Aortic Aneurysm Repair and Higher Long-term Aortic-related Mortality Compared With Men in a Population-based Study
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Indrani Sen, Jill J. Colglazier, Tiziano Tallarita, William Harmsen, Jay Mandrekar, and Manju Kalra
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
15. Cryopreserved Arterial Allografts vs Rifampin-Soaked Dacron for the Treatment of Infected Aortic and Iliac Grafts
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Armin Tabiei, Sebastian Cifuentes, Amy E. Glasgow, Manju Kalra, Bernardo C. Mendes, Jill J. Colglazier, Todd E. Rasmussen, Fahad Shuja, and Randall R. DeMartino
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
16. Cryopreserved Arterial Allografts Versus Autologous Vein for Arterial Reconstruction in Infected Fields
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Armin Tabiei, Sebastian Cifuentes, Jill J. Colglazier, Fahad Shuja, Manju Kalra, Bernardo C. Mendes, Melinda S. Schaller, Todd E. Rasmussen, and Randall R. DeMartino
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
17. Contemporary outcomes after treatment of aberrant subclavian artery and Kommerell's diverticulum
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Jonathan Bath, Mario D'Oria, Richard T. Rogers, Jill J. Colglazier, Drew J. Braet, Dawn M. Coleman, Salvatore T. Scali, Martin R. Back, Gregory A. Magee, Anastasia Plotkin, Philip Dueppers, Alexander Zimmermann, Rana O. Afifi, Sophia Khan, Devin Zarkowsky, Gregory Dyba, Michael C. Soult, Kevin Mani, Anders Wanhainen, Carlo Setacci, Massimo Lenti, Loay S. Kabbani, Mitchelle R. Weaver, Daniele Bissacco, Santi Trimarchi, Jordan B. Stoecker, Grace J. Wang, Zoltan Szeberin, Eniko Pomozi, Clare Moffatt, Hugh A. Gelabert, Shahed Tish, Andrew W. Hoel, Nicholas S. Cortolillo, Emily L. Spangler, Marc A. Passman, Giovanni De Caridi, Filippo Benedetto, Wei Zhou, Yousef Abuhakmeh, Daniel H. Newton, Christopher M. Liu, Giovanni Tinelli, Yamume Tshomba, Airi Katoh, Sammy S. Siada, Manar Khashram, Sinead Gormley, John R. Mullins, Zachary C. Schmittling, Thomas S. Maldonado, Amani D. Politano, Pawel Rynio, Arkadiusz Kazimierczak, Alexander Gombert, Houman Jalaie, Paolo Spath, Enrico Gallitto, Martin Czerny, Tim Berger, Mark G. Davies, Francesco Stilo, Nunzio Montelione, Luca Mezzetto, Gian Franco Veraldi, Sandro Lepidi, Peter Lawrence, and Karen Woo
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Aberrant subclavian artery ,Kommerell's diverticulum ,Surgery ,Cardiology and Cardiovascular Medicine ,Settore MED/22 - CHIRURGIA VASCOLARE - Published
- 2023
18. Vascular surgery integrated resident selection criteria in the pass or fail era
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Ahmed A. Sorour, Levester Kirksey, Francis J. Caputo, Hassan Dehaini, James Bena, Vincent L. Rowe, Jill J. Colglazier, Brigitte K. Smith, Murray L. Shames, and Sean P. Lyden
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Surgery ,Cardiology and Cardiovascular Medicine - Abstract
Vascular surgery integrated residency (VSIR) programs are highly competitive; however, criteria for resident selection remain opaque and non-standardized. The already unclear selection criteria will be further impacted by the impending transition of the United States Medical Licensing Examination (USMLE) Step 1 from numeric scores to a binary pass/fail outcome. The purpose of this study was to investigate the historical and anticipated selection criteria of VSIR applicants.This was a cross-sectional, nationwide, 59-item survey that was sent to all VSIR program directors (PDs). Data was analyzed using the Fisher exact test if categorical and the Mann-Whitney U test and the Kruskal-Wallis test if ordinal.Forty of 69 PDs (58%) responded to the survey. University-based programs constituted 85% of responders. Most VSIR PDs (65%) reported reviewing between 101 to 150 applications for 1 to 2 positions annually. Forty-two percent of the responding PDs reported sole responsibility for inviting applicants to interview, whereas 50% had a team of faculty responsible for reviewing applications. On a five-point Likert scale, letters of recommendation (LOR) from vascular surgeons or colleagues (a person the PD knows) were the most important objective criteria. Work within a team structure was rated highest among subjective criteria. The majority of respondents (72%) currently use the Step 1 score as a primary method to screen applicants. Regional differences in use of Step 1 score as a primary screening method were: Midwest (100%), Northeast (76%), South (43%), and West (40%) (P = .01). PDs responded that that they will use USMLE Step 2 score (42%) and LOR (10%) to replace USMLE Step 1 score. The current top ranked selection criteria are letters from a vascular surgeon, USMLE Step 1 score and overall LOR. The proposed top ranked selection criteria after transition of USMLE Step 1 to pass/fail include LOR overall followed by Step 2 score.This is the first study to evaluate the selection criteria used by PDs for VSIR. The landscape of VSIR selection criteria is shifting and increasing transparency is essential to applicants' understanding of the selection process. The transition of USMLE Step 1 to a pass/fail report will shift the attention to Step 2 scores and elevate the importance of other relatively more subjective criteria. Defining VSIR program selection criteria is an important first step toward establishing holistic review processes that are transparent and equitable.
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- 2022
19. Clinical presentation, operative management, and long-term outcomes of rupture after previous abdominal aortic aneurysm repair
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Indrani Sen, Irina Kanzafarova, Jennifer Yonkus, Bernardo C. Mendes, Jill J. Colglazier, Fahad Shuja, Randall R. DeMartino, Manju Kalra, and Todd E. Rasmussen
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Surgery ,Cardiology and Cardiovascular Medicine - Abstract
The aim of the present study was to evaluate the presentation trends, intervention, and survival of patients who had been treated for late abdominal aortic aneurysm rupture (LAR) after open repair (OR) or endovascular aortic aneurysm repair (EVAR).We reviewed the clinical data from a single-center, retrospective database for patients treated for LAR from 2000 to 2020. The end points were the 30-day mortality, major postoperative complication, and survival. The outcomes between LAR managed with EVAR (group I) vs OR were compared (group II).Of 390 patients with infrarenal aortic rupture, 40 (10%) had experienced aortic rupture after prior aortic repair and comprised the LAR cohort (34 men; age 78 ± 8 years). LAR had occurred before EVAR in 30 and before OR in 10 patients. LAR was more common in the second half of the study with 32 patients after 2010. LAR after prior OR was secondary to ruptured para-anastomotic pseudoaneurysms. After initial EVAR, LAR had occurred despite reintervention in 17 patients (42%). The time to LAR was shorter after prior EVAR than after OR (6 ± 4 vs 12 ± 4 years, respectively; P = .003). Treatment for LAR was EVAR for 25 patients (63%; group I) and OR for 15 (37%, group II). LAR after initial OR was managed with endovascular salvage for 8 of 10 patients. Endovascular management was more frequent in the latter half of the study period. In group I, fenestrated repair had been used for seven patients (28%). Salvage for the remaining cases was feasible with EVAR, aortic cuffs, or limb extensions. The incidence of free rupture, time to treatment, 30-day mortality (8% vs 13%; P = .3), complications (32% vs 60%; P = .1), and disposition were similar between the two groups. Those in group I had had less blood loss (660 vs 3000 mL; P .001) and less need for dialysis (0% vs 33%; P .001) than those in group II. The median follow-up was 21 months (interquartile range, 6-45 months). The overall 1-, 3-, and 5-year survival was 76%, 52%, and 41%, respectively, and was similar between groups (28 vs 22 months; P = .48). Late mortality was not related to the aorta.LAR after abdominal aortic aneurysm repair has been encountered more frequently in clinical practice, likely driven by the frequency of EVAR. However, most LARs, including those after previous OR, can now be salvaged with endovascular techniques with lower morbidity and mortality.
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- 2022
20. Cryopreserved Arterial Allografts Versus Rifampin-Soaked Dacron For The Treatment Of Infected Aortic And Iliac Aneurysms
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Armin Tabiei, Sebastian Cifuentes, Manju Kalra, Jill J. Colglazier, Bernardo C. Mendes, Melinda S. Schaller, Fahad Shuja, Todd E. Rasmussen, and Randall R. DeMartino
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
21. Perioperative Outcomes of Carotid–Subclavian Bypass or Transposition versus Endovascular Techniques for Left Subclavian Artery Revascularization during Nontraumatic Zone 2 Thoracic Endovascular Aortic Repair in the Vascular Quality Initiative
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Emanuel R. Tenorio, Jill J. Colglazier, Randall R. DeMartino, Fahad Shuja, Gustavo S. Oderich, Jussi M. Kärkkäinen, Mario D'Oria, and Bernardo C. Mendes
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Adult ,Male ,Canada ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Subclavian Artery ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,Revascularization ,030218 nuclear medicine & medical imaging ,Blood Vessel Prosthesis Implantation ,03 medical and health sciences ,Aortic aneurysm ,0302 clinical medicine ,Aneurysm ,Risk Factors ,medicine ,Humans ,Registries ,Prospective cohort study ,Stroke ,Aged ,Retrospective Studies ,Aged, 80 and over ,Aortic Aneurysm, Thoracic ,Spinal Cord Ischemia ,business.industry ,Endovascular Procedures ,General Medicine ,Perioperative ,Middle Aged ,Vascular surgery ,medicine.disease ,United States ,Surgery ,Aortic Dissection ,Carotid Arteries ,Treatment Outcome ,Ischemic Attack, Transient ,Cardiothoracic surgery ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The aim of our study is to examine the perioperative outcomes of carotid–subclavian bypass or transposition (CS-BpTp) versus endovascular techniques (ETs) for left subclavian artery (LSA) revascularization during nontraumatic zone 2 thoracic endovascular aortic repair (TEVAR). Methods We used prospectively collected data from the Society for Vascular Surgery Vascular Quality Initiative (VQI) to identify patients who had undergone TEVAR at participating centers (2013–2018). Patients were eligible for inclusion if they had undergone nontraumatic zone 2 TEVAR and concomitant LSA revascularization. Our main exposure of interest was LSA revascularization technique, CS-BpTp, or any ET. If a patient underwent multiple TEVAR procedures during the study period, the first case involving zone 2 was used for analysis. Preoperative patient characteristics were reviewed between treatment groups. The primary outcomes were mortality, transient ischemic attack (TIA)/stroke, and spinal cord ischemia (SCI). All outcomes were assessed up to 30 days postoperatively. Results A total of 837 patients were included in the study. The pathologies most frequently treated were aneurysm in 248 (34%) and dissection in 326 (45%). Overall, 721 subjects (86%) underwent CS-BpTp while 116 subjects (16%) underwent ETs. The latter included the following techniques: 23 chimney grafts, 3 scallops, 15 fenestrated grafts, and 75 branched grafts. Mortality was equal at 3% for both groups (P = 0.67). The rate of TIA/stroke was not significantly different in both groups (5.5% vs. 5%, P = 0.78). Similarly, the rate of SCI was 3% in the entire cohort without significant differences seen between treatment groups (P = 1). Multivariate logistic regression could not identify either CS-BpTp or ETs as independent predictors for death or TIA/stroke. Conclusions Within VQI, LSA revascularization during nontraumatic zone 2 TEVAR is safely and effectively achieved with either CS-BpTp or ETs across all nontraumatic thoracic aortic diseases. These techniques appear to be associated with similar perioperative outcomes in selected patients with low rates of mortality and major neurologic morbidity. Although no differences were seen in the proportion of early type I or III endoleaks, further prospective studies are warranted to elucidate the long-term durability of ETs compared with CS-BpTp.
- Published
- 2020
22. Predictors of Long-Term Aortic Growth and Disease Progression in Patients with Aortic Dissection, Intramural Hematoma, and Penetrating Aortic Ulcer
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Indrani Sen, Gustavo S. Oderich, Thomas C. Bower, Jill J. Colglazier, Meredith C. Hyun, Randall R. De Martino, Francesco Squizzato, Mario D Oria, Squizzato, F., Hyun, M. C., Sen, I., D'Oria, M., Bower, T., Oderich, G., Colglazier, J., and Demartino, R. R.
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medicine.medical_specialty ,Aortic Diseases ,Aortic dissection ,Disease ,Outcomes ,Article ,Aortic aneurysm ,Rochester Epidemiology Project ,Risk Factors ,Intramural hematoma ,Internal medicine ,medicine ,Humans ,In patient ,Ulcer ,Retrospective Studies ,Hematoma ,Predictors ,business.industry ,Proportional hazards model ,Disease progression ,General Medicine ,Prognosis ,medicine.disease ,Aortic Dissection ,Treatment Outcome ,Disease Progression ,Cardiology ,Female ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Predictor - Abstract
Background: We aimed to identify predictors of long-term aortic diameter change and disease progression in a population cohort of patients with newly diagnosed aortic dissection (AD), intramural hematoma (IMH), or penetrating aortic ulcer (PAU). Methods: We used the Rochester Epidemiology Project record linkage system to identify all Olmsted County, MN-USA, residents diagnosed with AD, IMH, and PAU (1995–2015). The endpoints were aortic diameter change, freedom from clinical disease progression (any related intervention, aortic aneurysm, new aortic syndrome, rupture or death) and disease resolution (complete spontaneous radiological disappear). Linear regression was used to assess aortic growth rate; predictors of disease progression were identified with Cox proportional hazards. Results: Of 133 incident cases, 46 ADs, 12 IMHs, and 28 PAUs with sufficient imaging data were included. Overall median follow-up was 8.1 years. Aortic diameter increase occurred in 40 ADs (87%, median 1.0 mm/year), 5 IMHs (42%, median 0.2 mm/year) and 14 PAUs (50%, median 0.4 mm/year). Symptomatic presentation (P = 0.045), connective tissue disorders (P = 0.005), and initial aortic diameter >42 mm (P = 0.013) were associated with AD growth rate. PAU depth >9 mm (P = 0.047) and female sex (P = 0.013) were associated with aortic growth rate in PAUs and IMHs. At 10 years, freedom from disease progression was 22% (95% CI 12–41) for ADs, 44% (95% CI 22–92) for IMHs, and 46% (95% CI 27–78) for PAUs. DeBakey I/IIIB AD (HR 3.09; P = 0.038), initial IMH aortic diameter (HR 1.4; P = 0.037) and PAU depth >10 mm (HR 3.92; P = 0.018) were associated with disease progression. No AD spontaneously resolved; resolution rate at 10 years was 22% (95% CI 0–45) for IMHs and 11% (95% CI 0–23) for PAUs. Conclusions: Aortic growth and clinical disease progression are observed in most patients with aortic syndromes, while spontaneous resolution is uncommon. Predictors of aortic growth and disease progression may be used to tailor appropriate follow-up and eventual early intervention.
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- 2022
23. Outcomes after Standalone Use of Gore Excluder Iliac Branch Endoprosthesis for Endovascular Repair of Isolated Iliac Artery Aneurysms
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Bernardo C. Mendes, Manju Kalra, Gustavo S. Oderich, Mario D'Oria, Jill J. Colglazier, Emanuel R. Tenorio, Fahad Shuja, and Randall R. DeMartino
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Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Femoral artery ,030204 cardiovascular system & hematology ,Prosthesis Design ,030218 nuclear medicine & medical imaging ,Blood Vessel Prosthesis Implantation ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Aneurysm ,Risk Factors ,medicine.artery ,medicine ,Humans ,Adverse effect ,Aged ,Retrospective Studies ,Endarterectomy ,Aged, 80 and over ,Iliac artery ,business.industry ,Endovascular Procedures ,External iliac artery ,General Medicine ,medicine.disease ,Internal iliac artery ,Blood Vessel Prosthesis ,Surgery ,Treatment Outcome ,Elective Surgical Procedures ,Iliac Aneurysm ,Concomitant ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The aim of our study was to describe outcomes of stand-alone use (i.e., without concomitant implantation of an aortic stent graft) of the Gore Excluder iliac branch endoprosthesis (IBE) for elective endovascular repair of isolated iliac artery aneurysms. Methods We evaluated all consecutive patients electively treated for isolated iliac artery aneurysms using standalone Gore Excluder IBE (January 2014–December 2018). Early (i.e., 30-day) endpoints were technical success, mortality, major adverse events (MAEs), and major access-site complications. Late endpoints were survival, freedom from aortic-related mortality (ARM), internal iliac artery (IIA) primary patency, IIA branch instability, graft-related adverse events (GRAEs), secondary interventions, endoleaks (ELs), aneurysm sac behavior, and new-onset buttock claudication (BC). Results A total of 11 consecutive patients (10 men; median age 75 years) were included. The technical success rate was 100%. At 30 days, mortality, MAEs, and major access-site complications were all 0%. Survival and freedom from ARM were 91% and 100%, respectively; only one nonaortic related death was recorded during follow-up. At a median follow-up of 14 months, IIA primary patency, IIA branch instability, and GRAEs were 100%, 0%, and 0%, respectively. No instances of graft migration ≥10 mm were detected. No graft-related secondary interventions were recorded, and 2 patients required a procedure-related secondary intervention 3 months after the index procedure (1 common femoral artery endarterectomy and 1 external iliac artery stenting). Although new-onset type 1 or type 3 ELs were never noted, one patient developed a new-onset type 2 EL. Aneurysm sac regression ≥5 mm was noted in 6 patients (55%), whereas in the remaining ones, the sac size was stable. No instances of new-onset BC were noted. Conclusions Use of standalone Gore Excluder IBE for elective endovascular repair of isolated iliac artery aneurysms is a safe, feasible, and effective treatment option. These results may support use of the technique as an effective means of endovascular reconstruction in patients with suitable anatomy.
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- 2020
24. En Bloc Celiac Axis Resection for Pancreatic Cancer: Classification of Anatomical Variants Based on Tumor Extent
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Randall R. DeMartino, Jill J. Colglazier, Michael L. Kendrick, Gustavo S. Oderich, Sean P. Cleary, Bernardo C. Mendes, Rory L. Smoot, Mark J. Truty, Thomas C. Bower, and David M. Nagorney
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Revascularization ,Gastroduodenal artery ,Young Adult ,Pancreatectomy ,Celiac Artery ,Major Pathologic Response ,Pancreatic cancer ,medicine.artery ,Humans ,Medicine ,Superior mesenteric artery ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Perioperative ,Middle Aged ,medicine.disease ,Surgery ,Pancreatic Neoplasms ,Treatment Outcome ,Female ,CA19-9 ,business ,Vascular Surgical Procedures - Abstract
Background En bloc celiac axis resection (CAR) for pancreatic cancer is considered increasingly after modern neoadjuvant chemotherapy (NAC). Appleby and distal pancreatectomy with CAR are anatomically inaccurate terms, as tumors can extend beyond celiac axis proper, requiring concurrent resection of the proper hepatic artery and/or superior mesenteric artery. Study Design A 3-level classification for CAR (class 1, 2, or 3) was developed after retrospective review of an arterial resection database describing anatomical variants that dictate pancreatectomy-type, formal arterial revascularization, and gastric preservation. Perioperative and oncologic outcomes were assessed. Results Of 90 CARs for pancreatic cancer, 89% patients received NAC, 35% requiring chemotherapeutic switch. There were 41 class 1, 33 class 2, and 16 class 3 CARs, with arterial and venous revascularization performed 62% and 66%, respectively. Ninety-day mortality decreased to 4% in the last 50 cases (p = 0.035); major morbidity was unchanged (55%). Any hepatic or gastric ischemia occurred in 20% and 10% patients, respectively, and arterial revascularization was protective. R0 resection rate (88%) was associated with chemoradiation (p = 0.004). Median overall survival was 36.2 months, superior with NAC (8.0 vs. 43.5 months). Predictors of survival after NAC included chemotherapy duration, carbohydrate antigen 19-9 response, pathologic response, and lymph node status. Major pathologic response (p = 0.036) and extended duration NAC (p = 0.007) were independent predictors on multivariate analysis. Conclusions Current terminology for CAR inadequately describes all operative variants. Our classification, based on the largest single-center series, allows complex operative planning and standardized reporting across institutions. Extent of arterial involvement determines pancreatectomy type, need for arterial revascularization, and likelihood of gastric preservation. Operative mortality has improved, morbidity remains significant, and survival favorable after extended NAC with associated pathologic responses; given these factors, CAR should only be considered in fit patients with objective NAC responses at specialized centers.
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- 2020
25. Outcomes of the Gore Excluder Iliac Branch Endoprosthesis Using Division Branches of the Internal Iliac Artery as Distal Landing Zones
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Mario D'Oria, Gustavo S. Oderich, Bernardo C. Mendes, Jill J. Colglazier, Manju Kalra, Emanuel R. Tenorio, Fahad Shuja, and Randall R. DeMartino
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Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Prosthesis Design ,Iliac Artery ,Endovascular aneurysm repair ,Blood Vessel Prosthesis Implantation ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Aneurysm ,Risk Factors ,medicine.artery ,Side branch ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Survival rate ,Vascular Patency ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Endovascular Procedures ,medicine.disease ,Trunk ,Common iliac artery ,Internal iliac artery ,Confidence interval ,Aortic Aneurysm ,Blood Vessel Prosthesis ,Surgery ,Treatment Outcome ,Iliac Aneurysm ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,business - Abstract
Purpose: To evaluate the outcomes of the Gore Excluder Iliac Branch Endoprosthesis (IBE) using division branches of the internal iliac artery (IIA) as distal landing zones. Materials and Methods: Between January 1, 2014, and December 31, 2018, 74 patients (mean age 74±7 years; 72 men) treated for aortoiliac or common iliac artery aneurysms had an IBE deployed with distal landing of the side branch within the main trunk (n=60) of the internal iliac artery (IIA) vs within a division branch (n=25). Thirteen (17%) patients received bilateral IBE implantations for a total of 85 vessels evaluated. Early endpoints were technical success, 30-day mortality, 30-day major adverse events (MAEs), and 30-day major access complications. Late endpoints were survival, primary and secondary IIA patency, freedom from IIA branch instability, freedom from new-onset buttock claudication, and aneurysm sac diameter changes. Time-dependent outcomes were reported as Kaplan-Meier curves with differences assessed using the log-rank test. Estimates are presented with the 95% confidence interval (CI). Results: The overall technical success rate was 97%, with 1 technical failure per group (p=0.43). Two patients, one from each group, died within 30 days (p=0.43). No significant differences were seen in the rates of 30-day MAEs (7% vs 17%, p=0.35) or major access complications (9% vs 11%, p>0.99) for patients receiving distal landing in the main trunk vs a division branch, respectively. The mean follow-up for the entire cohort was 19±12 months. The overall 1-year survival rate was 94% (95% CI 74% to 99%). The primary and secondary patency rates at 1 year were 98% (95% CI 88% to 99%) vs 95% (95% CI 72% to 99%, p=0.72) and 98% (95% CI 88% to 99%) vs 100% (p=0.41) for the main trunk vs division branch groups, respectively. Freedom from IIA branch instability estimates were also similar at 1-year follow-up [93% (95% CI 82% to 97%) vs 90% (95% CI 66% to 97%), p=0.29], as were the freedom from new-onset buttock claudication estimates [98% (95% CI 86% to 99%) and 94% (95% CI 67% to 99%), respectively; p=0.62]. Mean sac diameter change was 5.4±5.3 mm, not significantly different between the groups (p=0.85). Conclusion: Use of the posterior or anterior division of the IIA as a distal landing zone for the Gore Excluder IBE was safe and efficacious in the midterm. This technique may permit extending indications for endovascular repair of aortoiliac aneurysms to cases with unsuitable anatomy within the IIA main trunk. Long-term assessment is needed to affirm the efficacy of this technique.
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- 2020
26. Transfusion Timing and Postoperative Myocardial Infarction and Death in Patients Undergoing Common Vascular Procedures
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Gustavo S. Oderich, Fahad Shuja, Thomas C. Bower, Thomas Heafner, Manju Kalra, Katherine A. Bews, Jill J. Colglazier, and Randall R. DeMartino
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Male ,medicine.medical_specialty ,Time Factors ,Clinical Decision-Making ,Blood Loss, Surgical ,Myocardial Infarction ,Postoperative Hemorrhage ,030204 cardiovascular system & hematology ,Risk Assessment ,Time-to-Treatment ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Clinical endpoint ,Humans ,Medicine ,030212 general & internal medicine ,Myocardial infarction ,Risk factor ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Patient Selection ,Mortality rate ,Retrospective cohort study ,General Medicine ,Perioperative ,Vascular surgery ,medicine.disease ,Troponin ,Treatment Outcome ,Anesthesia ,Female ,Surgery ,Myocardial infarction diagnosis ,Erythrocyte Transfusion ,Cardiology and Cardiovascular Medicine ,business ,Vascular Surgical Procedures ,Biomarkers - Abstract
Perioperative allogenic blood transfusions, specifically packed red bloods cells (pRBC), after vascular surgery procedures are modifiable risk factors that are associated with increased cardiovascular events and 30-day mortality. The aim of this study is to evaluate the effect of transfusion timing (intraoperative vs. postoperative) on the rate of postoperative myocardial infarction (POMI) and death.Six surgical and endovascular modules within the Vascular Quality Initiative (VQI) from 2013 to 2017 were reviewed at a single institution. Transfusion data on elective and urgent cases were abstracted and all patients who underwent inpatient procedures had routine postoperative troponin/ECG testing. The primary endpoint was POMI utilizing the American Heart Association's third universal definition for myocardial infarction. These criteria include the detection of a rise/and or fall of cTnT with at least one value above the 99th percentile and with at least one of the following 1) symptoms of acute myocardial ischemia, 2) new ischemic ECG changes, 3) development of pathological Q waves, 4) imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with ischemic etiology. The secondary endpoint was 30-day all-cause mortality. Multivariable logistic regression analysis was utilized to evaluate the risk of transfusions on POMI and death.We identified 1,154 cases for analysis (299 abdominal aortic aneurysm [EVAR], 117 infrainguinal bypasses, 127 open abdominal aortic aneurysm [AAA], 41 suprainguinal bypasses, 168 thoracic endovascular aortic repair [TEVAR], and 402 peripheral vascular interventions). Overall, the POMI rate was 2% and mortality 1%. Rates of POMI differed by procedure type (P = 0.04), where infrainguinal bypass had the highest rate of POMI at 4%. Death rates did not vary by type of procedure (P = 0.89). Mean number of intraoperative pRBC and postoperative pRBC transfusion was higher for patients with POMI (intraop: 1.3 vs. 0.3, postop: 1.8 vs. 0.4, both P 0.01) and death (intraop: 1.4 vs. 0.3, postop: 2.5 vs. 0.4, both P 0.01). In addition, older age and coronary artery disease (CAD) were associated with POMI on univariate analysis. On multivariable analysis for POMI, CAD (odds ratio [OR] = 5.15, 95% confidence interval [CI] [2.00-13.24], P 0.001), receiving both an intraoperative and postoperative transfusion (OR = 6.20, 95% CI [1.78-21.55], P 0.01) as well as a postoperative transfusion only (OR = 5.70, 95% CI [1.81-17.94], P 0.01) compared to no transfusion were associated with higher odds of POMI; however intraoperative transfusion only was not (OR = 3.42, 95% CI [0.88-13.31], P = 0.08). On multivariable analysis, increasing age of the patient was associated with higher odds of death (OR = 1.08, 95% CI [1.01-1.15], P = 0.02) and statin use was highly protective (OR = 0.27, 95% CI [0.10-0.74], P = 0.01), but any intraoperative or postoperative transfusion compared to no transfusion was not associated with death after adjustment.In our series with routine postoperative troponin screening in the inpatient setting, the use of an isolated postoperative transfusion as well as cases requiring both an intraoperative and postoperative transfusion was associated with POMI. However, isolated intraoperative transfusion was not associated with POMI, and we did not identify an association of transfusion with 30-day mortality. These data suggest that the perioperative setting of transfusions is important in its impact on postoperative outcomes and needs to be accounted for when evaluating transfusion outcomes and indications.
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- 2020
27. Outcomes of Unilateral Versus Bilateral Use of the Iliac Branch Endoprosthesis for Elective Endovascular Treatment of Aorto-iliac Aneurysms
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Mario, D'Oria, Emanuel R, Tenorio, Gustavo S, Oderich, Randall R, DeMartino, Manju, Kalra, Fahad, Shuja, Jill J, Colglazier, and Bernardo C, Mendes
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Aged, 80 and over ,Male ,Time Factors ,Endovascular Procedures ,Prosthesis Design ,Blood Vessel Prosthesis ,Blood Vessel Prosthesis Implantation ,Treatment Outcome ,Iliac Aneurysm ,Humans ,Female ,Stents ,Vascular Patency ,Aged ,Retrospective Studies - Abstract
The aim of the study was to evaluate outcomes after bilateral implantation of the Gore Excluder Iliac Branch Endoprosthesis (IBE) versus those achieved after unilateral implantation.All consecutive patients electively treated in a single center for aorto-iliac aneurysm using the IBE device between January 1, 2014, and December 31, 2018, were reviewed. Early outcome measures were technical success, 30 days or in-hospital mortality, and major adverse events (MAE). Late outcome measures were survival, internal iliac artery (IIA) patency, and freedom from IIA branch instability.A total of 74 patients (97% males, mean age 74 ± 7 years) were included. Thirteen patients (17%) received bilateral IBE implantation for a total of 85 vessels evaluated. The technical success rate was 97% and was not significantly different between the two groups (p = .32). Two patients died within 30 days, both in the unilateral group (p = 1). No significant differences were seen in the rates of 30 days MAE (p = .10). At one year, the overall survival rate was 95 ± 2% vs 90 ± 3% in the unilateral and bilateral group, respectively (Log-rank = .05). There were no differences in 1-year primary and secondary patency rates between groups (Log-rank = .75 and Log-rank = .34, respectively). Freedom from IIA branch instability at one year was also not significantly different (unilateral: 94 ± 3% vs. bilateral: 82 ± 9%, Log-rank = .22)..Bilateral IBE use for elective endovascular treatment of aorto-iliac aneurysms appears safe and feasible and may achieve satisfactory short-term and mid-term outcomes. Bilateral IBE use should be employed judiciously in the context of a comprehensive risk/benefit evaluation.
- Published
- 2021
28. Thirty-year single-center experience with arterial thoracic outlet syndrome
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Grayson S. Pitcher, Indrani Sen, Bernardo C. Mendes, Fahad Shuja, Randall R. DeMartino, Thomas C. Bower, Manju Kalra, William S. Harmsen, and Jill J. Colglazier
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Adult ,Subclavian Artery ,Anticoagulants ,Arterial Occlusive Diseases ,Middle Aged ,Decompression, Surgical ,Thoracic Outlet Syndrome ,Treatment Outcome ,Ischemia ,Humans ,Surgery ,Chronic Pain ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
Arterial thoracic outlet syndrome (ATOS) is rare. We present our 30-year experience with the management of ATOS at a high-volume referral center.A retrospective review of all patients who had undergone primary operative treatment for ATOS from 1988 to 2018 was performed. ATOS was defined as subclavian artery pathology caused by extrinsic compression from a bony abnormality within the thoracic outlet.A total of 41 patients (45 limbs) underwent surgery for ATOS at a median age of 46 years (interquartile range [IQR], 34-58 years). Chronic symptoms (6 weeks) were present in 31 limbs (69%). Of the 45 limbs, 13 (29%) presented with acute limb ischemia (ALI), requiring urgent brachial artery thromboembolectomy (BAT) in 9 and catheter-directed thrombolysis and thrombectomy (CDT) in 4. All patients underwent thoracic outlet decompression. 31 limbs (69%) required subclavian artery reconstruction. No perioperative deaths and only one major adverse limb event occurred. Patients with ALI underwent staged thoracic outlet decompression after initial BAT or CDT at a median of 23 days (IQR, 11-140 days). Of the 13 limbs with an initial presentation of ALI, 8 (62%) had recurrent thromboembolic events before thoracic outlet decompression subsequently requiring 10 additional BATs and 1 CDT. The cumulative probability of recurrent embolization at 14, 30, and 90 days was 8.33% (95% confidence interval [CI], 1.28%-54.42%), 16.67% (95% CI, 4.70%-59.06%), and 33.33% (95% CI, 14.98-74.20%), respectively. The median follow-up for 32 patients (35 limbs) was 13 months (IQR, 5-36 months). Subclavian artery/graft primary and secondary patency was 87% and 90%, respectively, at 5 years by Kaplan-Meier analysis. Of the 35 limbs, 5 (14%) had chronic upper extremity pain and 5 (14%) had persistent weakness. Preoperative forearm or hand pain and brachial artery occlusion were associated with chronic pain (P = .04 and P = .03) and weakness (P = .03 and P = .02). Of the 13 limbs that presented with ALI, 11 had a median follow-up after thoracic outlet decompression of 6 months (IQR, 5-14 months), including 9 (82%) with oral anticoagulation therapy. Anticoagulation therapy had no effect on subclavian artery patency (P = 1.0) or the presence of chronic symptoms (P = .93).The presentation of ATOS is diverse, and the diagnosis can be delayed. Preoperative upper extremity pain and brachial artery occlusion in the setting of ALI were associated with chronic pain and weakness after thoracic outlet decompression. Delayed thoracic outlet decompression was associated with an increased risk of recurrent thromboembolic events for patients who presented with ALI. An early and accurate diagnosis of ATOS is necessary to reduce morbidity and optimize outcomes.
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- 2021
29. Aneurysms of the superior mesenteric artery and its branches
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Grayson S. Pitcher, Nolan C. Cirillo-Penn, Bernardo C. Mendes, Fahad Shuja, Randall R. DeMartino, Manju Kalra, Thomas C. Bower, William S. Harmsen, and Jill J. Colglazier
- Subjects
Male ,Blood Vessel Prosthesis Implantation ,Treatment Outcome ,Mesenteric Artery, Superior ,Endovascular Procedures ,Humans ,Surgery ,Aneurysm, Ruptured ,Middle Aged ,Cardiology and Cardiovascular Medicine ,Abdominal Pain ,Retrospective Studies - Abstract
Aneurysms of the superior mesenteric artery (SMA) and its branches are rare and account for only 6% to 15% of all visceral artery aneurysms. In the present report, we have described our 30-year experience with the management of aneurysms of the SMA and its branches at a high-volume referral center.A retrospective review of all patients with a diagnosis of an aneurysm of the SMA or one of its branches from 1988 to 2018 was performed. Pseudoaneurysms and mycotic aneurysms were excluded. The clinical presentation, etiology, aneurysm shape and size, treatment modalities, and outcomes were analyzed. The growth rate of the aneurysms was estimated using linear regression.A total of 131 patients with 144 aneurysms were reviewed. The patients were primarily men (64%), with a median age of 60 years. Of the 144 aneurysms, 57 were fusiform, 30 were saccular, and 57 were dissection-associated aneurysms. Of the 131 patients, 41 had had an isolated SMA branch aneurysm. Degenerative aneurysms were the most common etiology (66%). A total of 35 patients (27%) were symptomatic at presentation. Of the 144 aneurysms, 111 had multiple computed tomography angiograms available, with a median follow-up of 43.6 months (interquartile range, 10.6-87.2 months). Only 18 aneurysms (16%) had had an estimated growth rate of ≥1.0 mm/y. The initial aneurysm size was significantly associated with the growth rate for the fusiform aneurysms (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.0-1.3]; P = .02) but not for the saccular (OR, 0.91; 95% CI, 0.76-1.1; P = 1.1) or dissection-associated (OR, 1.2; 95% CI, 0.91-1.5; P = .20) aneurysms. Acute abdominal pain (OR, 5.9; 95% CI, 1.6-22; P = .01) and chronic abdominal pain (OR, 3.7; 95% CI, 1.1-13; P = .04) were associated with aneurysm growth. Only two patients had a ruptured aneurysm, both of whom presented with rupture with no prior imaging studies. These two patients had a diagnosis of fibromuscular dysplasia and systemic lupus erythematosus, respectively. Of the 131 patients, 46 (34%) had undergone operative repair, including 36 open revascularizations and 8 endovascular procedures. The average aneurysm size for these 46 patients was 24.0 ± 8.6 mm. One patient died perioperatively, and nine patients experienced perioperative complications (25%). Of the 144 aneurysms, 91 were 20 mm, with an average size of 13.4 ± 3.1 mm. These 91 aneurysms had been followed up for a median of 120.8 months (interquartile range, 30.5-232.2 months), with no ruptures within this cohort during the follow-up period.The present study represents one of the largest series on aneurysms of the SMA and its branches. Our results showed that aneurysms of the SMA are relatively stable. Patients with symptomatic and fusiform aneurysms had a greater risk of growth. Aneurysms 20 mm with a degenerative etiology can be safely monitored without treatment.
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- 2021
30. Outcomes In Partial And Complete Explantation Of Aortic Endografts For Endoleak
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Richard T. Rogers, Jill J. Colglazier, Mohammad Khasawneh, Randall R. DeMartino, Fahad Shuja, Bernardo C. Mendes, Thomas C. Bower, and Manju Kalra
- Subjects
Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2022
31. Vascular Surgery Integrated Resident Selection Criteria in the Step 1 Pass/Fail Era: A National Survey of Program Directors
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Ahmed A. Sorour, Lee Kirksey, Francis J. Caputo, Hassan Dehaini, Vincent L. Rowe, Jill J. Colglazier, Brigitte K. Smith, Murray L. Shames, and Sean P. Lyden
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2022
32. Incidence, Reintervention, and Survival Associated With Type II Endoleak After Elective EVAR in the Vascular Quality Initiative
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Randall R. DeMartino, Dan Neal, David H. Stone, Bernardo C. Mendes, Jill J. Colglazier, Mario D'oria, Bjoern D. Suckow, Benjamin N. Jacobs, and Salvatore T. Scali
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2022
33. Incidence and Predictors of Gastrointestinal Bleeding Following Mesenteric Revascularization
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Armin Farazdaghi, Jill J. Colglazier, Gustavo S. Oderich, Manju Kalra, Fahad Shuja, Melinda Schaller, Todd Rasmussen, Randall R. DeMartino, and Bernardo C. Mendes
- Subjects
Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2022
34. Outcomes of balloon-expandable versus self-expandable stent graft for endovascular repair of iliac aneurysms using iliac branch endoprosthesis
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Mohammad A. Khasawneh, Jill J. Colglazier, Manju Kalra, Randall R. DeMartino, Guilherme B.B. Lima, Giulianna B. Marcondes, Bernardo C. Mendes, Gustavo S. Oderich, Fahad Shuja, and Emanuel R. Tenorio
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Endoleak ,medicine.medical_treatment ,Prosthesis Design ,Blood Vessel Prosthesis Implantation ,Risk Factors ,Side branch ,medicine.artery ,Occlusion ,medicine ,Humans ,Iliac Aneurysm ,Vascular Patency ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Self expandable ,Endovascular Procedures ,Stent ,Intermittent Claudication ,medicine.disease ,Internal iliac artery ,Surgery ,Blood Vessel Prosthesis ,Stenosis ,Balloon expandable stent ,Treatment Outcome ,Female ,Stents ,business ,Cardiology and Cardiovascular Medicine - Abstract
PURPOSE The purpose of this study was to compare outcomes of internal iliac artery (IIA) stenting using balloon-expandable (BESG) or self-expandable stent grafts (SESG) during endovascular repair of aortoiliac aneurysms with iliac branch endoprosthesis (IBE; W. L. Gore, Flagstaff, Ariz). METHODS We retrospectively reviewed all consecutive patients treated for aortoiliac aneurysms using IBE between 2014 and 2020. IIA stenting was performed using either the IIA side branch SESG or a Gore VBX BESG (W. L. Gore). Indications for use of BESGs were "up-and-over" IBE technique for type IB endoleak after prior endovascular aortic aneurysm repair (EVAR), short IIA length, and need for IIA extension into divisional branches (outside instructions for use). End points included technical success, freedom from buttock claudication, primary IIA patency, and freedom from IIA branch instability (eg, branch-related death or rupture, occlusion, disconnection, or reintervention for stenosis, kink, or endoleak), freedom from type IC/IIIC endoleak, and freedom from secondary interventions. RESULTS There were 90 patients (86 males and 4 females) with a mean age of 74 ± 7 years treated by EVAR with 108 IBEs. Choice of stent was BESG in 43 and SESG in 65 targeted IIAs. BESGs were used more frequently in patients with prior EVAR (22% vs 2%; P = .003,), isolated IBEs (31% vs 2%; P < .001), and in patients with IIA aneurysms requiring stenting into divisional branches (36% vs 5%; P < .001). Technical success was similar for BESGs and SESGs (97% vs 100%; P = .40), respectively. The mean follow-up was 25 ± 16 months (range, 11-34 months). At 2 years, freedom from buttock claudication was 100% for BESG and 95 ± 3% for SESG (Log-rank 0.26), with no difference in primary patency (BESG, 100% vs SESG, 94 ± 4%; Log-rank 0.94). There were four (9%) IIA-related endoleaks in the BESG group and one (2%) in the SESG group (P = .08). Freedom from IIA branch instability was 87 ± 6% for BESG and 96 ± 3% for SESG at 2 years (Log-rank 0.043). Freedom from type IC/IIIC endoleak was 87 ± 7% for BESG and 98 ± 2% for SESG at the same interval (Log-rank 0.06). There was no difference in freedom from reinterventions for BESG and SESG (92 ± 6% vs 98 ± 2%; Log-rank 0.34), respectively. CONCLUSIONS BESGs were used more frequently during IBE procedures indicated for failed EVAR, isolated common iliac aneurysms, and IIA aneurysms requiring extension into divisional branches. Despite these differences and BESG being used outside instructions for use, both stent types had similar primary patency, freedom from buttock claudication, and freedom from reinterventions. However, BESGs were associated with higher rates of IIA-related branch instability.
- Published
- 2022
35. Asymptomatic Troponin Leak After Major Vascular Reconstruction With Routine Postoperative Troponin Testing is Associated With Increased Short- and Long-term Mortality
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Randall R. DeMartino, Jesse Manunga, Armin Farazdaghi, Fahad Shuja, Jill J. Colglazier, Peter Gloviczki, Manju Kalra, Thomas C. Bower, and Bernardo C. Mendes
- Subjects
Leak ,medicine.medical_specialty ,biology ,business.industry ,Troponin ,Asymptomatic ,Internal medicine ,Vascular reconstruction ,Cardiology ,medicine ,biology.protein ,Surgery ,Long term mortality ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
36. Open Surgical Revascularization for Aortoiliac Occlusive Disease Across Surgical Eras and Surgeon Experience
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Ali Khalifeh, Thomas C. Bower, Bernardo C. Mendes, Todd E. Rasmussen, Randall R. De Martino, Jill J. Colglazier, Fahad Shuja, and Manju Kalra
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medicine.medical_specialty ,business.industry ,medicine ,Aortoiliac occlusive disease ,Surgery ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Surgical revascularization - Published
- 2021
37. A 33-Year-Old Man With Circumflex Aortic Arch and 4-cm Right Subclavian Artery Aneurysm
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Jill J. Colglazier, Alberto Pochettino, Eduardo Danduch, and Bianca Kenyon
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2022
38. The Long-Term Fate of Aortic Branches in Patients with Aortic Dissection
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Jill J. Colglazier, Randall R. DeMartino, Bernardo C. Mendes, Manju Kalra, Fahad Shuja, Gustavo S. Oderich, Thomas C. Bower, and Francesco Squizzato
- Subjects
Marfan syndrome ,Male ,medicine.medical_specialty ,Time Factors ,Minnesota ,Lumen (anatomy) ,030204 cardiovascular system & hematology ,Risk Assessment ,Article ,Marfan Syndrome ,03 medical and health sciences ,0302 clinical medicine ,Rochester Epidemiology Project ,Aneurysm ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Aorta ,Vascular Patency ,Aged ,Retrospective Studies ,Aortic dissection ,Aged, 80 and over ,Proportional hazards model ,business.industry ,Incidence ,Hazard ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Progression-Free Survival ,Aortic Aneurysm ,Aortic Dissection ,Cardiology ,Disease Progression ,Female ,Surgery ,business ,Cardiology and Cardiovascular Medicine ,Dilatation, Pathologic - Abstract
Objective Late morbidity and mortality related to aortic branches in patients with aortic dissection (AD) have not been well described. We investigated the fate of aortic branches in a population cohort of patients with newly diagnosed AD. Methods We used the Rochester Epidemiology Project record linkage system to identify all Olmsted County, Minnesota, residents with a diagnosis of AD from 1995 to 2015. Only patients with >30 days of available follow-up imaging studies were included in the present analysis. The primary outcome was freedom from any branch-related event (any intervention, aneurysm, malperfusion, rupture, or death occurring after the acute phase >14 days). The secondary outcome was the diameter change in the aortic branches. Univariate and multivariable Cox proportional hazards models were used to identify the predictors of branch-related events. Univariate and multivariate linear regression models were used to assess the aortic branch growth rate. Results Of 77 total incident AD cases, 58 patients who had survived and had imaging follow-up studies available were included, 28 (48%) with type A and 30 (52%) with type B AD. The presentation was acute in 39 patients (67%), 6 (10%) of whom had had branch malperfusion. Of 177 aortic branches involved by the AD, 81 (46%) had arisen from the true lumen, 33 (19%) from the false lumen, and 63 (36%) from both. After the acute phase, freedom from any branch-related event at 15 years was 48% (95% confidence interval [CI], 32%-70%). A total of 31 branch-related events had occurred in 19 patients within 15 years, including 12 interventions (76% freedom; 95% CI, 63%-92%), 10 aneurysms (67% freedom; 95% CI, 50%-90%), 8 cases of malperfusion (76% freedom; 95% CI, 61%-94%), and 1 rupture (94% freedom; 95% CI, 84%-100%). No branch-related deaths had occurred. Type B AD (hazard ratio [HR], 3.5; 95% CI, 1.1-10.8; P = .033), patency of the aortic false lumen (HR, 6.8; 95% CI, 1.1-42.2; P = .038), and malperfusion syndrome at presentation (HR, 6.0; 95% CI, 1.3-28.6; P = .023) were predictors of late aortic branch-related events. The overall growth rate of aortic branches was 1.3 ± 3.0 mm annually. Patency of the aortic false lumen, initial branch diameter, and Marfan syndrome were significantly associated with diameter increase. Conclusions In patients with AD, aortic branch involvement was responsible for significant long-term morbidity, without any related mortality. Type B AD, patency of the aortic false lumen, and malperfusion syndrome at presentation resulted in a greater risk of branch events during the long-term follow-up. Dilatation of the aortic branches was observed in one third of cases during follow-up, especially in the case of a patent aortic false lumen or the presence of Marfan syndrome.
- Published
- 2021
39. Five-Year Mortality and Freedom From Intervention After Medical Management of Type B Aortic Intramural Hematoma
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Randall R. De Martino, Jill J. Colglazier, Manju Kalra, Todd E. Rasmussen, Fahad Shuja, Thomas C. Bower, Parvathi Balachandran, and Bernardo C. Mendes
- Subjects
medicine.medical_specialty ,Intramural hematoma ,business.industry ,Intervention (counseling) ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
40. A New Quality Measure Defines Performance After Elective Endovascular Abdominal Aortic Aneurysm Repair
- Author
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Randall R. De Martino, Lily E. Johnston, Thomas C. Bower, Jill J. Colglazier, Fahad Shuja, Mario D'Oria, Manju Kalra, Todd E. Rasmussen, and Bernardo C. Mendes
- Subjects
medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Measure (physics) ,medicine ,Surgery ,Quality (business) ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Abdominal aortic aneurysm ,media_common - Published
- 2021
41. Incidence and Natural History of Isolated Abdominal Aortic Dissection: A Population Based Assessment From 1995-2015
- Author
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Jill J. Colglazier, Gustavo S. Oderich, Mario D'Oria, Salome Weiss, Thomas C. Bower, Randall R. DeMartino, Manju Kalra, and Indrani Sen
- Subjects
Marfan syndrome ,Adult ,Male ,Abdominal pain ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Minnesota ,Population ,030204 cardiovascular system & hematology ,Endovascular aneurysm repair ,Risk Assessment ,Article ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,Risk Factors ,medicine ,Humans ,030212 general & internal medicine ,610 Medicine & health ,education ,Aged ,Retrospective Studies ,Aortic dissection ,Aged, 80 and over ,education.field_of_study ,business.industry ,Incidence ,Middle Aged ,medicine.disease ,Prognosis ,Abdominal aortic aneurysm ,Surgery ,Stenosis ,Aortic Dissection ,cardiovascular system ,Disease Progression ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Aortic Aneurysm, Abdominal - Abstract
Background Isolated abdominal dissection (IAD) is an uncommon clinical problem that is less well-understood than thoracic aortic dissection (AD). We performed a population-based assessment of the incidence, natural history, and treatment outcomes of IAD to better characterize this disease. Methods We used the Rochester Epidemiology Project to identify all Olmsted County, MN residents with a diagnosis of AD, intramural hematoma or penetrating ulcer (1995-2015). Diagnostic imaging of all patients was reviewed to confirm the diagnosis of IAD for inclusion. Presentation, treatment, and outcomes were reviewed. Survival of IAD patients was compared to age- and sex-matched population controls 3:1. Results Of 133 residents with aortic syndrome (AD, intramural hematoma, or penetrating ulcer), 23 were initially diagnosed with IAD. Nine were reclassified as having a penetrating aortic ulcer and were excluded, leaving 14 patients for review (10 male [71%]; mean age, 71 years). Three patients (21%) were symptomatic (abdominal pain, back pain, hypertension) and none had malperfusion or rupture. Prior aortic dilatation was present in eight patients (57%) and Marfan syndrome in one (7%). Two patients (14%) had iatrogenic IAD. Initial management was medical in 13 and endovascular aneurysm repair in one (symptomatic subacute, infrarenal dissection with small aneurysm). The median clinical and imaging follow-up was 6.7 years (range, 0-17 years). An abdominal aortic aneurysm occurred in eight (six at the time of IAD diagnosis, one at 2.9 years, and one at 5.2 years after diagnosis). The average growth in the entire cohort was 0.9 ± 0.4 cm, which translated to an average growth rate of 0.09 cm/year. Subsequent intervention was performed in two patients; for severe aortic stenosis with claudication in one (infrarenal aortic stenting) and increasing aortic size in one (open repair). One patient required reintervention (thrombolysis and stenting for endovascular aneurysm repair limb thrombosis). Survival for IAD at 1, 3, and 5 years was 93%, 85%, and 76%, respectively, compared with population controls at 98%, 85%, and 71%, respectively (long rank P = .38). Mortality was due to cardiovascular causes in three patients (21%) and no deaths were aortic related. Major adverse cardiac events occurred in five patients (36%) owing to heart failure. Conclusions IAD is rare. The initial management for asymptomatic patients is medical. The aortic growth rate is slow, with no aortic-related mortality and a low rate of aortic intervention. The overall mortality is similar to population controls. Heart failure and cardiac-related death are prevalent, suggesting that close cardiovascular care is needed in this patient population.
- Published
- 2020
42. Long-term symptom improvement and health-related quality of life after operative management of median arcuate ligament syndrome
- Author
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Keouna Pather, Thomas C. Bower, Emanuel R. Tenorio, Gustavo S. Oderich, Jill J. Colglazier, Manju Kalra, Jussi M. Kärkkäinen, and Randall R. DeMartino
- Subjects
Adult ,Male ,medicine.medical_specialty ,Abdominal pain ,Time Factors ,Exacerbation ,Adolescent ,Population ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Postoperative Complications ,Quality of life ,Median Arcuate Ligament Syndrome ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Patient Reported Outcome Measures ,Treatment Failure ,Adverse effect ,education ,Retrospective Studies ,education.field_of_study ,business.industry ,Middle Aged ,medicine.disease ,Decompression, Surgical ,Cross-Sectional Studies ,Respiratory failure ,Quality of Life ,Surgery ,Female ,Laparoscopy ,medicine.symptom ,business ,Cardiology and Cardiovascular Medicine ,Median arcuate ligament syndrome - Abstract
Objective To investigate long-term symptom improvement and health-related quality of life (HRQOL) after operative intervention for median arcuate ligament syndrome (MALS). Methods Clinical data of all consecutive patients treated by operative management of MALS from 1999 to 2018 were reviewed. A cross-sectional questionnaire using the Visick score, the Gastrointestinal Quality of Life Index, and Short Form (SF)-12v2 questionnaires was performed to assess long-term outcomes. The SF-12 HRQOL domains were compared between symptom-free and symptomatic patient groups and to averages for the US general population. Treatment failure was defined as no relief after surgery and Visick category 3 to 4 symptoms. Freedom from symptoms was estimated at 5 years. Results A total of 100 patients were treated for MALS (mean age, 38 ± 18 years; 75% female). Open surgical release was performed in 81 and laparoscopic release in 19 patients. The most common presenting symptom was abdominal pain in 99 patients with postprandial exacerbation in 85. There was no mortality. Major adverse events at 30 days had occurred in 21 patients (open 19, laparoscopic 2) including myocardial infarction (n = 1), pancreatitis (n = 2), respiratory failure (n = 4), estimated blood loss of more than 1 L (n = 8), and postoperative ileus (n = 8). One patient treated by laparoscopic release required conversion for an aortic injury, which was treated by primary repair and splenectomy. Forty-six patients responded to the questionnaire with a mean follow-up of 8 ± 4 years. Initial symptom resolution or improvement was reported by 38 patients (83%), whereas 8 patients (17%) reported treatment failure. Seven of the 38 patients (18%) with initial treatment success reported symptom recurrence. The estimated 5-year freedom from symptoms was 67 ± 7%. All SF-12 HRQOL domains were significantly lower and below the average population range in symptomatic patients compared with those who were symptom free, in which all domains were within the average population range. The Gastrointestinal Quality of Life Index scores were also significantly lower in symptomatic patients. Forty respondents (87%) reported that they would still undergo operative management if given the choice, including all respondents who reported symptom recurrence. Conclusions The operative management of MALS can be performed with a low rate of complications. Approximately two-thirds of respondents were free of symptoms 5 years after the procedure. Treatment success in symptom-free patients was associated with an improved HRQOL on par with the population average compared with symptomatic patients. The vast majority of respondents would opt to have the operation again if given a choice. However, patients should be well-informed about the possibility of failure to relieve symptoms and symptom recurrence.
- Published
- 2020
43. Outcomes of Onyx® Embolization of Type II Endoleaks After Endovascular Repair of Abdominal Aortic Aneurysms
- Author
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Keouna Pather, Ying Huang, Gustavo S. Oderich, Randall R. DeMartino, Peter Gloviczki, Aleem K. Mirza, Thomas C. Bower, Gergely D. Mozes, Jill J. Colglazier, Fahad Shuja, Bernardo C. Mendes, Haraldur Bjarnason, and Manju Kalra
- Subjects
Subset Analysis ,Male ,medicine.medical_specialty ,Time Factors ,Endoleak ,medicine.medical_treatment ,Tantalum ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Aortic aneurysm ,Blood Vessel Prosthesis Implantation ,0302 clinical medicine ,Hematoma ,Aneurysm ,Risk Factors ,Medicine ,Humans ,Dimethyl Sulfoxide ,Embolization ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Endovascular Procedures ,Onyx embolization ,Retrospective cohort study ,General Medicine ,medicine.disease ,Embolization, Therapeutic ,Surgery ,Drug Combinations ,Treatment Outcome ,Female ,Polyvinyls ,Cardiology and Cardiovascular Medicine ,business ,Abdominal surgery ,Aortic Aneurysm, Abdominal - Abstract
Background Type II endoleaks (T2ELs) are common following endovascular repair of abdominal aortic aneurysms (EVAR). Embolization with ethylene vinyl alcohol copolymer (Onyx) may present an effective treatment alternative for T2ELs. Due to limited data supporting its use, we sought to analyze outcomes of Onyx embolization for T2ELs. Methods Retrospective review of consecutive patients treated for T2ELs utilizing Onyx embolization agent from 2009–2018. All pre- and post-Onyx intervention CT scans were analyzed for diameter and volume changes with 3D reconstruction software. The primary outcomes were change in maximum AAA diameter and volume. Secondary outcomes included additional interventions, rupture, and mortality. A subset analysis was performed with patients with isolated T2ELs (no other types of endoleaks present). Results We identified 85 patients (73 males, mean age 77.6 ± 7.6 years) who underwent 112 Onyx interventions. Average time to first Onyx intervention after index EVAR was 3.3 ± 2.6 years and average sac growth was 6.3 ± 6.7 mm. Patients underwent mean 1.3 Onyx interventions using a mean of 4.9 ± 4.7 ml for treatment. Three complications occurred (Onyx extravasation, colon ischemia, and access site hematoma). Mean follow-up was 2.5 ± 2.1 years after initial Onyx treatment. At the most recent follow-up, sac diameter stabilization was seen in 47% and reduction >5 mm was seen in 19%. Sac growth of >5 mm was seen in 34% of patients following the first Onyx intervention. In our subset of isolated T2EL, 72% had sac stabilization or reduction >5 mm. Four patients experienced a ruptured aneurysm (3 had active type 1 endoleaks). Rupture-free survival was 95% at 5 years, and overall survival was 54% at 5 years. Notably, increasing Onyx interventions were not associated with sac stabilization or reduction (OR 0.6, P = 0.1). On multivariable analysis, AAA sac diameter stabilization or reduction was independently associated with BMI >30 kg/m2 (OR 4.2, P = 0.01) and having only 1 Onyx intervention (OR 3.8, P = 0.02). Conclusions Onyx for embolization of T2ELs resulted in AAA sac diameter stabilization or reduction in 66% of patients, and up to 72% in isolated T2ELs. Further, increasing Onyx interventions were not associated with either aneurysm sac stabilization or reduction. Given its similar outcomes to other embolization strategies in the literature, Onyx embolization for management of T2ELs needs to be judiciously considered, particularly for T2ELs persisting after an initial Onyx embolization intervention.
- Published
- 2019
44. Frailty Remains Highly Correlated With Mortality After Endovascular Aneurysm Repair in Octogenarians
- Author
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Randall R. DeMartino, Lily E. Johnston, Gustavo S. Oderich, Bernardo C. Mendes, Fahad Shuja, Jill J. Colglazier, Thomas C. Bower, and Mario D'Oria
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Endovascular aneurysm repair - Published
- 2020
45. Peri-operative Outcomes Of Carotid-subclavian Bypass Versus Endovascular Techniques for Left Subclavian Artery Revacularization During Non-traumatic Zone 2 Thoracic Endovascular Aortic Repair
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Randall R. De Martino, Mario D'Oria, Jill J. Colglazier, Jussi M. Kärkkäinen, Gustavo S. Oderich, Bernardo C. Mendes, Emanuel R. Tenorio, and Fahad Shuja
- Subjects
medicine.medical_specialty ,business.industry ,Non traumatic ,Left subclavian artery ,Medicine ,Surgery ,Perioperative ,Cardiology and Cardiovascular Medicine ,business ,Aortic repair ,Carotid subclavian bypass - Published
- 2019
46. Tumor-specific prognosis of mutation-positive patients with head and neck paragangliomas
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Randall R. DeMartino, Katarzyna Polonis, Thomas C. Bower, Jan L. Kasperbauer, Manju Kalra, William S. Harmsen, Indrani Sen, Jill J. Colglazier, William F. Young, and Gustavo S. Oderich
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Time Factors ,Databases, Factual ,medicine.medical_treatment ,Group ii ,Tumor specific ,medicine.disease_cause ,Gastroenterology ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Paraganglioma ,Risk Factors ,Internal medicine ,medicine ,Humans ,Head and neck ,Genetic testing ,Retrospective Studies ,Paraganglioma, Extra-Adrenal ,Mutation ,medicine.diagnostic_test ,business.industry ,Neoplasms, Second Primary ,Middle Aged ,medicine.disease ,Progression-Free Survival ,Radiation therapy ,Succinate Dehydrogenase ,030104 developmental biology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Surgery ,Female ,SDHD ,Neoplasm Recurrence, Local ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Genetic testing to identify succinate dehydrogenase (SDH) mutations in patients with head and neck paraganglioma (HNP) has been in clinical practice for more than a decade. However, the recurrence and metachronous tumor occurrence risks in surgically treated mutation-positive patients are not well studied. Methods Clinical and procedural details of consecutive patients who underwent excision for HNP from January 1996 to October 2016 were retrospectively reviewed. End points included recurrence, metachronous tumor detection, and mortality. Germline DNA was tested to identify mutations in SDHx genes. Patients were divided into three groups on the basis of genetic testing: group I, positive; group II, negative; and group III, unknown or offered but not tested. Results HNP was diagnosed in 268 patients, 214 (147 female; mean age, 47 years) included in this study. Directed genetic testing was performed in 68; mutations were detected in SDH in 47 (69%), a majority SDHD. In group I, 47 patients had 64 procedures for 81 tumors (52 carotid body tumors [CBTs]); 17 (36%) were bilateral, 7 (15%) multiple, 3 (6%) functional, and 7 (15%) malignant. Residual tumor in 10 was significant in 2, managed by radiation therapy and reoperation. Local recurrence was detected in 12 patients (25%) at a median of 8 years; 11 metachronous mediastinal and retroperitoneal paragangliomas were detected in 8 (17%) at a median of 13 years. Systemic metastases occurred in five (10%). Six patients (13%) had more than one recurrence. In group II, 21 patients had 22 procedures for 23 tumors, 17 CBTs. Two (9%) were bilateral and two (9%) malignant. Excision was complete in all with no recurrence or systemic metastasis at last follow-up. For group III, 146 patients underwent 153 procedures for 156 tumors, 95 CBTs; 7 (5%) were bilateral, 2 (1%) multiple, 8 (5%) functional, and 1 (0.6%) malignant. Local recurrence was detected in nine (6%) at a median of 9 years and metachronous HNP in three (2%) at a median of 5 years. Systemic metastases occurred in two (1%). Mortality was 4% in group I and 3% in group III, none procedure or tumor related. Group I (mutation positive) had 10-year overall, recurrence-free, and metachronous tumor-free survival rates of 93%, 69.4%, and 73%, respectively, lower than the other groups (P Conclusions Bilateral, functional, malignant, recurrent, and metachronous tumors are more common in SDH mutation-positive patients with HNP. Overall survival in patients with HNP is high. Metachronous tumors or local recurrences occur late, and long-term follow-up is necessary.
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- 2019
47. Patient and institutional factors associated with postoperative opioid prescribing after common vascular procedures
- Author
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Kristine T. Hanson, Jill J. Colglazier, Houssam Farres, Randall R. DeMartino, Elizabeth B. Habermann, Albert G. Hakaim, Samuel R. Money, Gustavo S. Oderich, Victor J. Davila, Edward D. Gifford, William M. Stone, Richard J. Fowl, Warren A. Oldenburg, Manju Kalra, Thomas C. Bower, and Fahad Shuja
- Subjects
Male ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Logistic regression ,Opioid prescribing ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Risk Factors ,Medicine ,Humans ,030212 general & internal medicine ,Medical prescription ,Practice Patterns, Physicians' ,Aged ,Retrospective Studies ,Pain, Postoperative ,business.industry ,Opioid naive ,Perioperative ,Tobacco Use Disorder ,Length of Stay ,Analgesics, Opioid ,Opioid ,Prescription opioid ,Emergency medicine ,Surgery ,Female ,Cardiology and Cardiovascular Medicine ,business ,Vascular Surgical Procedures ,medicine.drug - Abstract
Overprescription of postoperative opioid medication is a major contributor to the opioid abuse epidemic in the United States. Research into prescribing practices has suggested that patients be limited to 7 days or 200 morphine milligram equivalents (MME) after surgical procedures. Our aim was to identify patient or institutional factors associated with increased opioid prescriptions.Opioid naive patients from an integrated health system undergoing one of nine surgical and endovascular procedures tracked within the Vascular Quality Initiative from 2015 to 2017 were identified and matched to their discharge and refill opioid prescriptions. Discharge opioid prescriptions were converted to MME. The primary outcome was discharge MME200, and secondary outcomes were procedure-specific top-quartile opioid prescription and medication refills. Multivariable logistic regression was used to assess patient and perioperative factors associated with each outcome.Among 1546 opioid naive patients, 739 (48%) received a discharge opioid prescription; median MME was 0 (interquartile range, 0-150), and 349 (23%) had200 MME. Among those with a discharge prescription, median MME was 180 (interquartile range, 150-300). MME varied by procedure (P .001), with highest MME after suprainguinal bypass (median, 225) and infrainguinal bypass (200) and lowest MME after carotid artery stenting, carotid endarterectomy, and percutaneous peripheral vascular intervention (all medians of 0). On multivariable analysis, factors associated with MME200 included younger patient age (65 vs ≥ 80 years; odds ratio [OR], 3.0; 95% confidence interval [CI], 1.9-4.6; P .001), treating institution B vs A (OR, 3.50; 95% CI, 2.42-5.07; P .001) and C vs A (OR, 3.90; 95% CI, 2.66-5.74; P .001), procedure-specific top-quartile length of stay (OR, 1.45; 95% CI, 1.01-2.08; P = .047), and prior tobacco use (OR, 1.60; 95% CI, 1.07-2.37; P = .02). The same variables along with current tobacco use and lack of preoperative aspirin were associated with procedure-specific top-quartile MME at discharge. Chronic beta-blocker use was protective of top-quartile MME. Based on the observed variability, an institutional standard for opioid prescribing has been developed for standardization.Opioid prescriptions at discharge vary with the invasiveness of vascular surgical procedures. Less than 25% of patients receive200 MME. Variation by center represents a lack of standardization in prescribing practices and an opportunity for further improvement based on developed guidelines. Patient factors and procedure type can alert clinicians to patients at risk of higher than recommended MME.
- Published
- 2019
48. Patient-Reported Outcomes of Surgical Management of Functional Popliteal Artery Entrapment Syndrome
- Author
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Parvathi Balachandran, Keouna Pather, Randall R. DeMartino, Jill J. Colglazier, Mohammad A. Khasawneh, and Thomas C. Bower
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Popliteal artery entrapment syndrome ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease - Published
- 2021
49. Outcome of Explanted Aortic Endografts: A Single-Center Experience
- Author
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Jill J. Colglazier, Gustavo S. Oderich, Thomas C. Bower, Mohammad A. Khasawneh, Manju Kalra, Bernardo C. Mendes, and Randall R. DeMartino
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,Single Center ,business ,Outcome (game theory) - Published
- 2020
50. Thirty-Year Experience With Aneurysms of the Superior Mesenteric Artery and Its Branches
- Author
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Nolan C. Cirillo-Penn, Fahad Shuja, Thomas C. Bower, Randall R. De Martino, Grayson Pitcher, Manju Kalra, Jill J. Colglazier, and Bernardo C. Mendes
- Subjects
medicine.medical_specialty ,business.industry ,medicine.artery ,medicine ,Surgery ,Superior mesenteric artery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2020
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