68 results on '"Jieun Son"'
Search Results
2. Development of Brain Computer Interface based Action Observation Program with Functional Electrical Stimulation device(FES).
- Author
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Jieun Son and Jeonghun Ku
- Published
- 2019
- Full Text
- View/download PDF
3. Supplementary Data from Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
- Author
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Chiara Ambrogio, Pasi A. Jänne, Mark M. Awad, Prafulla C. Gokhale, David Santamaria, Marie-Julie Nokin, Elodie Richard, Yunhan Chen, Kshiti H. Dholakia, Jens Köhler, Amanda J. Redig, Chhayheng Chhoeu, Joao Victor Alessi, Yue Xu, Jiaqi Li, Heidi M. Haikala, Mika Lin, Haiyun Wang, Raymond Paranal, Xinan Wang, Yoonji Eum, Enrico Patrucco, Alessia Mira, Jeffrey J. Okoro, Jieun Son, and Biagio Ricciuti
- Abstract
Supplementary Data from Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
- Published
- 2023
4. Supplementary Data from A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
- Author
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Pasi A. Jänne, Nathanael S. Gray, Michael J. Eck, Michael D. Cameron, Prafulla C. Gokhale, Man Xu, Stephen Wang, Michael J. Poitras, Pinar Ö. Eser, Nicholas P. Kwiatkowski, John M. Hatcher, Mika Lin, Alyssa Verano, Heidi M. Haikala, Yoonji Eum, Tyler S. Beyett, Jaebong Jang, and Jieun Son
- Abstract
Supplementary Data from A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
- Published
- 2023
5. Data from Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
- Author
-
Geoffrey R. Oxnard, Alexander Drilon, S. Michael Rothenberg, Pasi A. Jänne, Marc Ladanyi, Barry S. Taylor, Lynette M. Sholl, Bob T. Li, Jaclyn F. Hechtman, Kevin Ebata, Morana Vojnic, Jenna E. Scanlon, Elizabeth A. Olek, Binoj C. Nair, Marina S.D. Milan, Mika Lin, Elaine M. Kelley, Dahlia N. Henry, Elena V. Ivanova, Eric Gladstone, Monika A. Davare, Arrien A. Bertram, Jieun Son, Jennifer F. Kherani, Romel Somwar, Sarah E. Clifford, Melissa L. Johnson, and Ezra Y. Rosen
- Abstract
Purpose:The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%–2% of non–small cell lung cancers (NSCLC) and rarely in other cancer types. Selpercatinib is a highly selective RET kinase inhibitor that has recently been approved by the FDA in lung and thyroid cancers with activating RET gene fusions and mutations. Molecular mechanisms of acquired resistance to selpercatinib are poorly understood.Patients and Methods:We studied patients treated on the first-in-human clinical trial of selpercatinib (NCT03157129) who were found to have MET amplification associated with resistance to selpercatinib. We validated MET activation as a targetable mediator of resistance to RET-directed therapy, and combined selpercatinib with the MET/ALK/ROS1 inhibitor crizotinib in a series of single patient protocols (SPP).Results:MET amplification was identified in posttreatment biopsies in 4 patients with RET fusion–positive NSCLC treated with selpercatinib. In at least one case, MET amplification was clearly evident prior to therapy with selpercatinib. We demonstrate that increased MET expression in RET fusion–positive tumor cells causes resistance to selpercatinib, and this can be overcome by combining selpercatinib with crizotinib. Using SPPs, selpercatinib with crizotinib were given together generating anecdotal evidence of clinical activity and tolerability, with one response lasting 10 months.Conclusions:Through the use of SPPs, we were able to offer combination therapy targeting MET-amplified resistance identified on the first-in-human study of selpercatinib. These data suggest that MET dependence is a recurring and potentially targetable mechanism of resistance to selective RET inhibition in advanced NSCLC.
- Published
- 2023
6. Supplementary Methods from Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
- Author
-
Geoffrey R. Oxnard, Alexander Drilon, S. Michael Rothenberg, Pasi A. Jänne, Marc Ladanyi, Barry S. Taylor, Lynette M. Sholl, Bob T. Li, Jaclyn F. Hechtman, Kevin Ebata, Morana Vojnic, Jenna E. Scanlon, Elizabeth A. Olek, Binoj C. Nair, Marina S.D. Milan, Mika Lin, Elaine M. Kelley, Dahlia N. Henry, Elena V. Ivanova, Eric Gladstone, Monika A. Davare, Arrien A. Bertram, Jieun Son, Jennifer F. Kherani, Romel Somwar, Sarah E. Clifford, Melissa L. Johnson, and Ezra Y. Rosen
- Abstract
Supplementary Methods
- Published
- 2023
7. Figure S2 from Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
- Author
-
Geoffrey R. Oxnard, Alexander Drilon, S. Michael Rothenberg, Pasi A. Jänne, Marc Ladanyi, Barry S. Taylor, Lynette M. Sholl, Bob T. Li, Jaclyn F. Hechtman, Kevin Ebata, Morana Vojnic, Jenna E. Scanlon, Elizabeth A. Olek, Binoj C. Nair, Marina S.D. Milan, Mika Lin, Elaine M. Kelley, Dahlia N. Henry, Elena V. Ivanova, Eric Gladstone, Monika A. Davare, Arrien A. Bertram, Jieun Son, Jennifer F. Kherani, Romel Somwar, Sarah E. Clifford, Melissa L. Johnson, and Ezra Y. Rosen
- Abstract
Supplemental Figure 2
- Published
- 2023
8. Data from Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
- Author
-
Chiara Ambrogio, Pasi A. Jänne, Mark M. Awad, Prafulla C. Gokhale, David Santamaria, Marie-Julie Nokin, Elodie Richard, Yunhan Chen, Kshiti H. Dholakia, Jens Köhler, Amanda J. Redig, Chhayheng Chhoeu, Joao Victor Alessi, Yue Xu, Jiaqi Li, Heidi M. Haikala, Mika Lin, Haiyun Wang, Raymond Paranal, Xinan Wang, Yoonji Eum, Enrico Patrucco, Alessia Mira, Jeffrey J. Okoro, Jieun Son, and Biagio Ricciuti
- Abstract
Purpose:Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly heterogeneous, and data on the potential isoform-dependent therapeutic vulnerabilities are still lacking.Experimental Design:We developed an isogenic cell-based platform to compare the oncogenic properties and specific therapeutic actionability of KRAS-mutant isoforms. In parallel, we analyzed clinicopathologic and genomic data from 3,560 patients with non–small cell lung cancer (NSCLC) to survey allele-specific features associated with oncogenic KRAS mutations.Results:In isogenic cell lines expressing different mutant KRAS isoforms, we identified isoform-specific biochemical, biological, and oncogenic properties both in vitro and in vivo. These exclusive features correlated with different therapeutic responses to MEK inhibitors, with KRAS G12C and Q61H mutants being more sensitive compared with other isoforms. In vivo, combined KRAS G12C and MEK inhibition was more effective than either drug alone. Among patients with NSCLCs that underwent comprehensive tumor genomic profiling, STK11 and ATM mutations were significantly enriched among tumors harboring KRAS G12C, G12A, and G12V mutations. KEAP1 mutation was significantly enriched among KRAS G12C and KRAS G13X LUADs. KRAS G13X-mutated tumors had the highest frequency of concurrent STK11 and KEAP1 mutations. Transcriptomic profiling revealed unique patterns of gene expression in each KRAS isoform, compared with KRAS wild-type tumors.Conclusions:This study demonstrates that KRAS isoforms are highly heterogeneous in terms of concurrent genomic alterations and gene-expression profiles, and that stratification based on KRAS alleles should be considered in the design of future clinical trials.
- Published
- 2023
9. Data from A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
- Author
-
Pasi A. Jänne, Nathanael S. Gray, Michael J. Eck, Michael D. Cameron, Prafulla C. Gokhale, Man Xu, Stephen Wang, Michael J. Poitras, Pinar Ö. Eser, Nicholas P. Kwiatkowski, John M. Hatcher, Mika Lin, Alyssa Verano, Heidi M. Haikala, Yoonji Eum, Tyler S. Beyett, Jaebong Jang, and Jieun Son
- Abstract
In-frame insertions in exon 20 of HER2 are the most common HER2 mutations in patients with non–small cell lung cancer (NSCLC), a disease in which approved EGFR/HER2 tyrosine kinase inhibitors (TKI) display poor efficiency and undesirable side effects due to their strong inhibition of wild-type (WT) EGFR. Here, we report a HER2-selective covalent TKI, JBJ-08–178–01, that targets multiple HER2 activating mutations, including exon 20 insertions as well as amplification. JBJ-08–178–01 displayed strong selectivity toward HER2 mutants over WT EGFR compared with other EGFR/HER2 TKIs. Determination of the crystal structure of HER2 in complex with JBJ-08–178–01 suggests that an interaction between the inhibitor and Ser783 may be responsible for HER2 selectivity. The compound showed strong antitumoral activity in HER2-mutant or amplified cancers in vitro and in vivo. Treatment with JBJ-08–178–01 also led to a reduction in total HER2 by promoting proteasomal degradation of the receptor. Taken together, the dual activity of JBJ-08–178–01 as a selective inhibitor and destabilizer of HER2 represents a combination that may lead to better efficacy and tolerance in patients with NSCLC harboring HER2 genetic alterations or amplification.Significance:This study describes unique mechanisms of action of a new mutant-selective HER2 kinase inhibitor that reduces both kinase activity and protein levels of HER2 in lung cancer.
- Published
- 2023
10. A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
- Author
-
Jieun Son, Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa Verano, Mika Lin, John M. Hatcher, Nicholas P. Kwiatkowski, Pinar Ö. Eser, Michael J. Poitras, Stephen Wang, Man Xu, Prafulla C. Gokhale, Michael D. Cameron, Michael J. Eck, Nathanael S. Gray, and Pasi A. Jänne
- Subjects
Cancer Research ,Lung Neoplasms ,Oncology ,Receptor, ErbB-2 ,Carcinoma, Non-Small-Cell Lung ,Mutation ,Humans ,Antineoplastic Agents ,Exons ,skin and connective tissue diseases ,Protein Kinase Inhibitors ,neoplasms - Abstract
In-frame insertions in exon 20 of HER2 are the most common HER2 mutations in patients with non–small cell lung cancer (NSCLC), a disease in which approved EGFR/HER2 tyrosine kinase inhibitors (TKI) display poor efficiency and undesirable side effects due to their strong inhibition of wild-type (WT) EGFR. Here, we report a HER2-selective covalent TKI, JBJ-08–178–01, that targets multiple HER2 activating mutations, including exon 20 insertions as well as amplification. JBJ-08–178–01 displayed strong selectivity toward HER2 mutants over WT EGFR compared with other EGFR/HER2 TKIs. Determination of the crystal structure of HER2 in complex with JBJ-08–178–01 suggests that an interaction between the inhibitor and Ser783 may be responsible for HER2 selectivity. The compound showed strong antitumoral activity in HER2-mutant or amplified cancers in vitro and in vivo. Treatment with JBJ-08–178–01 also led to a reduction in total HER2 by promoting proteasomal degradation of the receptor. Taken together, the dual activity of JBJ-08–178–01 as a selective inhibitor and destabilizer of HER2 represents a combination that may lead to better efficacy and tolerance in patients with NSCLC harboring HER2 genetic alterations or amplification. Significance: This study describes unique mechanisms of action of a new mutant-selective HER2 kinase inhibitor that reduces both kinase activity and protein levels of HER2 in lung cancer.
- Published
- 2022
11. Artificial homeostasis system with electrochemical sensing and pharmaceutical stimulation for impaired brain function
- Author
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Han Hee Jung, Hyeokjun Lee, Jeongdae Ha, Jeongrak Park, Seongtak Kang, Jinmo Kim, Han Na Jung, Junwoo Yea, Saehyuck Oh, Janghwan Jekal, Soojung Song, Jieun Son, Tae Sang Yu, Youngjeon Lee, Jinyoung Won, Kyung Seob Lim, Ji-Woong Choi, Jae-Woong Jeong, Young Min Song, Samhwan Kim, Jong-Cheol Rah, Taeyoon Lee, Hohyun Keum, Sheng Xu, Yoon Kyung Lee, Yong-Seok Oh, and Kyung-In Jang
- Abstract
Treatment trends for Parkinson’s disease are revolutionizing from conventional pharmaceutical treatment depending on the patient’s symptoms to closed-loop electroceutical treatment in order to minimize the crucial pharmacokinetic drawbacks. Over the decades, closed-loop neuromodulations have been achieved by electroceutical devices based on continuous electrical stimulation and sensing of electrophysiological biomarkers. However, critical drawbacks have been observed with vulnerable to artefacts from the nearby stimulation electrode and frequent adjustment of stimulation parameters. On the contrary, direct monitoring of neurochemicals allows high spatial resolution, signal specificity and interference-free detection compared to closed-loop DBS. Here, we propose an artificial homeostasis system with electrochemical sensing and pharmaceutical stimulation for impaired brain function. In order to implement the artificial homeostasis system by mimicking the brain system, we have reported an implantable multi-deformable double-sided DA-sensing probe with an all-in-one structure by integrating three-electrode system and drug refillable microfluidic probe with controllable injection for synchronized diagnosis and treatment. The experimental and computational analysis clearly indicate that the proposed probes could serve as potential tools for building artificial homeostasis by the bio-responsive closed-loop system with an electropharmaceutical approach.
- Published
- 2023
12. Current Status and Challenges of Performance Evaluation System for Local Public Corporations Using Meta-Evaluation
- Author
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Jieun Son and Sungmin Roh
- Published
- 2021
13. A study on the operation and management improvement of local research institutes: Focusing on comparison with government-funded research institutes
- Author
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Jieun Son and Sukwon Ryu
- Subjects
Government ,Business ,Public administration - Published
- 2021
14. GC-like Graphene-Coated Quartz Crystal Microbalance Sensor with Microcolumns
- Author
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Sungho Kim, Ki-Seok An, Wooseok Song, Sun Sook Lee, Jongsun Lim, Sung Myung, Seong Ku Kim, Soyoung Kim, Jieun Son, and Seulki Ji
- Subjects
010302 applied physics ,Materials science ,Polydimethylsiloxane ,Graphene ,Analytical chemistry ,02 engineering and technology ,Quartz crystal microbalance ,021001 nanoscience & nanotechnology ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,Adsorption ,chemistry ,law ,0103 physical sciences ,Electrode ,Molecule ,General Materials Science ,Gas chromatography ,0210 nano-technology ,Selectivity - Abstract
Many research groups have been interested in the quartz crystal microbalance (QCM)-based gas sensors due to their superb sensitivity originated from direct mass sensing at the ng level. Despite such high sensitivities observed from QCM sensors, their ability to identify gas compounds still needs to be enhanced. Herein, we report a highly facile method that utilizes microcolumns integrated on a QCM gas-responsive system with enhanced chemical selectivity for sensing and ability to identify volatile organic compound single gases. Graphene oxide (GO) flakes are coated on the QCM electrode to substantially increase the adsorption of gas molecules, and periodic polydimethylsiloxane microcolumns with micrometer-scale width and height were installed on the GO-coated QCM electrode. The observed frequency shifts upon sensing of various single gas molecules (such as ethanol, acetone, hexane, etc.) can be analyzed accurately using a simple exponential model. The QCM sensor system with and without the microcolumn both exhibited high detection response values above 50 ng/cm2 for sensing of the gases. Notably, the QCM sensor equipped with the microcolumn features gas identification ability, which is observed as distinct diverging behavior of time constants upon detection of different gases caused by the difference in diffusional transfer of molecules through the microcolumns. For example, the difference in the calculated time constant between ethanol and acetone increased from 22.6 to 92.1 s after installation of the microcolumn. This approach provides an easy and efficient method for identification of single gases, and it may be applied in various advanced sensor systems to enhance their gas selectivity.
- Published
- 2021
15. Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
- Author
-
Marc Ladanyi, Bob T. Li, Jennifer Kherani, Elena Ivanova, Arrien A. Bertram, Ezra Y. Rosen, Elaine M. Kelley, Jieun Son, Marina S.D. Milan, Jaclyn F. Hechtman, Romel Somwar, Kevin Ebata, Alexander Drilon, Melissa Lynne Johnson, Sarah E. Clifford, Jenna E. Scanlon, Barry S. Taylor, Geoffrey R. Oxnard, Eric Gladstone, S Michael Rothenberg, Elizabeth Olek, Monika A. Davare, Binoj Nair, Pasi A. Jänne, Mika Lin, Lynette M. Sholl, Morana Vojnic, and Dahlia Henry
- Subjects
Adult ,Male ,0301 basic medicine ,Cancer Research ,Lung Neoplasms ,Oncogene Proteins, Fusion ,Combination therapy ,Pyridines ,Pilot Projects ,Article ,Receptor tyrosine kinase ,Fusion gene ,03 medical and health sciences ,0302 clinical medicine ,Crizotinib ,Carcinoma, Non-Small-Cell Lung ,Antineoplastic Combined Chemotherapy Protocols ,ROS1 ,medicine ,Humans ,Lung cancer ,Protein Kinase Inhibitors ,Aged ,Clinical Trials, Phase I as Topic ,biology ,business.industry ,Proto-Oncogene Proteins c-ret ,Gene Amplification ,Cancer ,Middle Aged ,Proto-Oncogene Proteins c-met ,medicine.disease ,Treatment Outcome ,030104 developmental biology ,Oncology ,Drug Resistance, Neoplasm ,RET Fusion Positive ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Pyrazoles ,Female ,business ,medicine.drug - Abstract
Purpose: The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%–2% of non–small cell lung cancers (NSCLC) and rarely in other cancer types. Selpercatinib is a highly selective RET kinase inhibitor that has recently been approved by the FDA in lung and thyroid cancers with activating RET gene fusions and mutations. Molecular mechanisms of acquired resistance to selpercatinib are poorly understood. Patients and Methods: We studied patients treated on the first-in-human clinical trial of selpercatinib (NCT03157129) who were found to have MET amplification associated with resistance to selpercatinib. We validated MET activation as a targetable mediator of resistance to RET-directed therapy, and combined selpercatinib with the MET/ALK/ROS1 inhibitor crizotinib in a series of single patient protocols (SPP). Results: MET amplification was identified in posttreatment biopsies in 4 patients with RET fusion–positive NSCLC treated with selpercatinib. In at least one case, MET amplification was clearly evident prior to therapy with selpercatinib. We demonstrate that increased MET expression in RET fusion–positive tumor cells causes resistance to selpercatinib, and this can be overcome by combining selpercatinib with crizotinib. Using SPPs, selpercatinib with crizotinib were given together generating anecdotal evidence of clinical activity and tolerability, with one response lasting 10 months. Conclusions: Through the use of SPPs, we were able to offer combination therapy targeting MET-amplified resistance identified on the first-in-human study of selpercatinib. These data suggest that MET dependence is a recurring and potentially targetable mechanism of resistance to selective RET inhibition in advanced NSCLC.
- Published
- 2021
16. KRASQ61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non–Small Cell Lung Cancer
- Author
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Hua Jin, Jiaqi Li, Kenneth D. Westover, Lianbo Li, Pasi A. Jänne, Jieun Son, Asim K. Bera, Sudershan R. Gondi, Chiara Ambrogio, Qing Li, Cheng Xiong Xu, Emily Campbell, Zhi Wei Zhou, Xing Xiao Li, and Jeffrey J. Okoro
- Subjects
0301 basic medicine ,MAPK/ERK pathway ,Cancer Research ,Mutation ,GTP' ,Chemistry ,MEK inhibitor ,GTPase ,medicine.disease_cause ,Cell biology ,Cell membrane ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,medicine ,KRAS ,PI3K/AKT/mTOR pathway - Abstract
Assembly of RAS molecules into complexes at the cell membrane is critical for RAS signaling. We previously showed that oncogenic KRAS codon 61 mutations increase its affinity for RAF, raising the possibility that KRASQ61H, the most common KRAS mutation at codon 61, upregulates RAS signaling through mechanisms at the level of RAS assemblies. We show here that KRASQ61H exhibits preferential binding to RAF relative to PI3K in cells, leading to enhanced MAPK signaling in in vitro models and human NSCLC tumors. X-ray crystallography of KRASQ61H:GTP revealed that a hyperdynamic switch 2 allows for a more stable interaction with switch 1, suggesting that enhanced RAF activity arises from a combination of absent intrinsic GTP hydrolysis activity and increased affinity for RAF. Disruption of KRASQ61H assemblies by the RAS oligomer–disrupting D154Q mutation impaired RAF dimerization and altered MAPK signaling but had little effect on PI3K signaling. However, KRASQ61H oligomers but not KRASG12D oligomers were disrupted by RAF mutations that disrupt RAF–RAF interactions. KRASQ61H cells show enhanced sensitivity to RAF and MEK inhibitors individually, whereas combined treatment elicited synergistic growth inhibition. Furthermore, KRASQ61H tumors in mice exhibited high vulnerability to MEK inhibitor, consistent with cooperativity between KRASQ61H and RAF oligomerization and dependence on MAPK signaling. These findings support the notion that KRASQ61H and functionally similar mutations may serve as predictive biomarkers for targeted therapies against the MAPK pathway. Significance: These findings show that oncogenic KRASQ61H forms a cooperative RAS–RAF ternary complex, which renders RAS-driven tumors vulnerable to MEKi and RAFi, thus establishing a framework for evaluating RAS biomarker-driven targeted therapies.
- Published
- 2020
17. Regulatory reform in the era of new technological development: The role of organizational factors in the public sector
- Author
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Jieun Son, Soonae Park, and Don S. Lee
- Subjects
Public Sector Organizations ,Regulatory Reform ,Public Administration ,Sociology and Political Science ,Economic policy ,business.industry ,Public sector ,Regulatory reform ,business ,Law ,New Technological Development - Abstract
What is the role of organizational factors in fostering regulatory reform in response to new technological development? Existing studies provide useful frameworks to understand regulatory reform in rapidly changing circumstances but still lack a systematic analysis of how organizational factors affect regulatory reform in the public sector. To fill this gap, we examine the impact of several institutional elements that are central to defining organizational characteristics, such as job tasks, bureaucratic autonomy, and organizational culture. We theorize that regulatory reform is more likely when public sector organizations are more receptive to external changes, which are determined by these characteristics. We leverage original surveys from over 1,000 civil servants in Korea, one of the front runners in new technological development, and find support for our prediction. We find that the implementation of regulatory reforms is more likely when 1) organizational tasks are relevant to scientific and technological development, 2) higher levels of bureaucratic autonomy are granted, 3) agency heads demonstrate stronger leadership, and 4) organizational culture is less authoritarian. Our study makes clear contributions to the literature on public management and regulation theory, and has important implications for regulatory reform in the face of new technological development.
- Published
- 2020
18. Thiourea-Based Extraction and Deposition of Gold for Electroless Nickel Immersion Gold Process
- Author
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Cafer T. Yavuz, Jong-In Han, Jieun Son, and Yeongran Hong
- Subjects
Materials science ,Scanning electron microscope ,General Chemical Engineering ,Metallurgy ,Extraction (chemistry) ,Electronic packaging ,Electroless nickel immersion gold ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,Industrial and Manufacturing Engineering ,Corrosion ,chemistry.chemical_compound ,020401 chemical engineering ,Thiourea ,chemistry ,0204 chemical engineering ,0210 nano-technology ,Deposition (law) ,Surface finishing - Abstract
Gold electroless plating for surface finishing of electronic circuits, named electroless nickel immersion gold (ENIG), is widely practiced in the electronics packaging industry. Noncyanide substitu...
- Published
- 2020
19. Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer
- Author
-
Biagio Ricciuti, Jieun Son, Jeffrey J. Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M. Haikala, Jiaqi Li, Yue Xu, Joao Victor Alessi, Chhayheng Chhoeu, Amanda J. Redig, Jens Köhler, Kshiti H. Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C. Gokhale, Mark M. Awad, Pasi A. Jänne, and Chiara Ambrogio
- Subjects
Mitogen-Activated Protein Kinase Kinases ,Cancer Research ,Kelch-Like ECH-Associated Protein 1 ,Lung Neoplasms ,NF-E2-Related Factor 2 ,Carcinoma ,digestive system diseases ,respiratory tract diseases ,Proto-Oncogene Proteins p21(ras) ,Oncology ,Carcinoma, Non-Small-Cell Lung ,Mutation ,Humans ,Protein Isoforms ,Non-Small-Cell Lung ,neoplasms - Abstract
Purpose:Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly heterogeneous, and data on the potential isoform-dependent therapeutic vulnerabilities are still lacking.Experimental Design:We developed an isogenic cell-based platform to compare the oncogenic properties and specific therapeutic actionability of KRAS-mutant isoforms. In parallel, we analyzed clinicopathologic and genomic data from 3,560 patients with non–small cell lung cancer (NSCLC) to survey allele-specific features associated with oncogenic KRAS mutations.Results:In isogenic cell lines expressing different mutant KRAS isoforms, we identified isoform-specific biochemical, biological, and oncogenic properties both in vitro and in vivo. These exclusive features correlated with different therapeutic responses to MEK inhibitors, with KRAS G12C and Q61H mutants being more sensitive compared with other isoforms. In vivo, combined KRAS G12C and MEK inhibition was more effective than either drug alone. Among patients with NSCLCs that underwent comprehensive tumor genomic profiling, STK11 and ATM mutations were significantly enriched among tumors harboring KRAS G12C, G12A, and G12V mutations. KEAP1 mutation was significantly enriched among KRAS G12C and KRAS G13X LUADs. KRAS G13X-mutated tumors had the highest frequency of concurrent STK11 and KEAP1 mutations. Transcriptomic profiling revealed unique patterns of gene expression in each KRAS isoform, compared with KRAS wild-type tumors.Conclusions:This study demonstrates that KRAS isoforms are highly heterogeneous in terms of concurrent genomic alterations and gene-expression profiles, and that stratification based on KRAS alleles should be considered in the design of future clinical trials.
- Published
- 2022
20. Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of
- Author
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Pınar Özden, Eser, Raymond M, Paranal, Jieun, Son, Elena, Ivanova, Yanan, Kuang, Heidi M, Haikala, Ciric, To, Jeffrey J, Okoro, Kshiti H, Dholakia, Jihyun, Choi, Yoonji, Eum, Atsuko, Ogino, Pavlos, Missios, Dalia, Ercan, Man, Xu, Michael J, Poitras, Stephen, Wang, Kenneth, Ngo, Michael, Dills, Masahiko, Yanagita, Timothy, Lopez, Mika, Lin, Jeanelle, Tsai, Nicolas, Floch, Emily S, Chambers, Jennifer, Heng, Rana, Anjum, Alison D, Santucci, Kesi, Michael, Alwin G, Schuller, Darren, Cross, Paul D, Smith, Geoffrey R, Oxnard, David A, Barbie, Lynette M, Sholl, Magda, Bahcall, Sangeetha, Palakurthi, Prafulla C, Gokhale, Cloud P, Paweletz, George Q, Daley, and Pasi A, Jänne
- Subjects
ErbB Receptors ,Lung Neoplasms ,Drug Resistance, Neoplasm ,Cell Line, Tumor ,Mutation ,Humans ,Protein Kinase Inhibitors ,Article - Abstract
The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in EGFR-mutant non–small cell lung cancer is limited by the development of drug resistance. One mechanism of EGFR inhibitor resistance occurs through amplification of the human growth factor receptor (MET) proto-oncogene, which bypasses EGFR to reactivate downstream signaling. Tumors exhibiting concurrent EGFR mutation and MET amplification are historically thought to be codependent on the activation of both oncogenes. Hence, patients whose tumors harbor both alterations are commonly treated with a combination of EGFR and MET tyrosine kinase inhibitors (TKIs). Here, we identify and characterize six patient-derived models of EGFR-mutant, MET-amplified lung cancer that have switched oncogene dependence to rely exclusively on MET activation for survival. We demonstrate in this MET-driven subset of EGFR TKI-refractory cancers that canonical EGFR downstream signaling was governed by MET, even in the presence of sustained mutant EGFR expression and activation. In these models, combined EGFR and MET inhibition did not result in greater efficacy in vitro or in vivo compared to single-agent MET inhibition. We further identified a reduced EGFR:MET mRNA expression stoichiometry as associated with MET oncogene dependence and single-agent MET TKI sensitivity. Tumors from 10 of 11 EGFR inhibitor–resistant EGFR-mutant, MET-amplified patients also exhibited a reduced EGFR:MET mRNA ratio. Our findings reveal that a subset of EGFR-mutant, MET-amplified lung cancers develop dependence on MET activation alone, suggesting that such patients could be treated with a single-agent MET TKI rather than the current standard-of-care EGFR and MET inhibitor combination regimens.
- Published
- 2021
21. Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer
- Author
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Emily S. Chambers, Alwin Schuller, Stephen Wang, Dalia Ercan, Mika Lin, Pınar Özden Eser, Raymond M. Paranal, Nicolas Floc'h, Sangeetha Palakurthi, Alison D. Santucci, Jeffrey J. Okoro, Geoffrey R. Oxnard, Man Xu, Kenneth H. Ngo, Jeanelle Tsai, Ciric To, Lynette M. Sholl, George Q. Daley, Michael Dills, Pavlos Missios, Kesi Michael, Paul D. Smith, Yoonji Eum, Magda Bahcall, Yanan Kuang, David A. Barbie, Masahiko Yanagita, Jennifer C. Heng, Rana Anjum, Prafulla C. Gokhale, Elena Ivanova, Jieun Son, Kshiti Dholakia, Heidi M. Haikala, Darren Cross, Jihyun Choi, Michael J. Poitras, Pasi A. Jänne, Timothy Lopez, Cloud P. Paweletz, and Atsuko Ogino
- Subjects
biology ,business.industry ,Extramural ,Mutant ,General Medicine ,Drug resistance ,medicine.disease ,Cancer research ,biology.protein ,Medicine ,Single agent ,Clinical efficacy ,Non small cell ,Epidermal growth factor receptor ,business ,Lung cancer - Abstract
A subset of drug-resistant EGFR -mutant MET -amplified lung cancer switches oncogenic dependence to MET and is treatable with MET inhibitor monotherapy.
- Published
- 2021
22. Bounded rationality, blame avoidance, and political accountability: how performance information influences management quality
- Author
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Jieun Son, Sun Hyoung Kim, and Sounman Hong
- Subjects
Process management ,ComputingMilieux_THECOMPUTINGPROFESSION ,Performance management ,media_common.quotation_subject ,05 social sciences ,Management quality ,Organizational performance ,Bounded rationality ,0506 political science ,Management Information Systems ,Blame ,Politics ,Management of Technology and Innovation ,0502 economics and business ,Accountability ,050602 political science & public administration ,Quality (business) ,Psychology ,050203 business & management ,media_common - Abstract
We examine performance impact on management by investigating whether information on past organizational performance (‘performance feedback’) influences future managerial quality. We employ a regres...
- Published
- 2019
23. ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
- Author
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Wenjing Su, Radha Mukherjee, Rona Yaeger, Jieun Son, Jianing Xu, Na Na, Neilawattie Merna Timaul, Jaclyn Hechtman, Viktoriya Paroder, Mika Lin, Marissa Mattar, Juan Qiu, Qing Chang, Huiyong Zhao, Jonathan Zhang, Megan Little, Yuta Adachi, Sae-Won Han, Barry S. Taylor, Hiromichi Ebi, Omar Abdel-Wahab, Elisa de Stanchina, Charles M. Rudin, Pasi A. Jänne, Frank McCormick, Zhan Yao, and Neal Rosen
- Subjects
ErbB Receptors ,Neurofibromin 1 ,ras GTPase-Activating Proteins ,Humans ,Guanosine Triphosphate ,Cell Biology ,Proto-Oncogene Proteins A-raf ,Molecular Biology ,Article ,Protein Binding ,Signal Transduction - Abstract
RAF protein kinases are effectors of the GTP-bound form of the small guanosine triphosphatase RAS and function by phosphorylating MEK. We showed here that expression of ARAF activated RAS in a kinase-independent manner. Binding of ARAF to RAS displaced the GTPase-activating protein NF1 and antagonized NF1-mediated inhibition of RAS. This reduced ERK-dependent inhibition of RAS and increased RAS-GTP. By this mechanism, ARAF regulated the duration and consequences of RTK-induced RAS activation and supported the RAS output of RTK-dependent tumor cells. In human lung cancers with EGFR mutation, amplification of ARAF was associated with acquired resistance to EGFR inhibitors, which was overcome by combining EGFR inhibitors with an inhibitor of the protein tyrosine phosphatase SHP2 to enhance inhibition of nucleotide exchange and RAS activation.
- Published
- 2022
24. KRAS
- Author
-
Zhi-Wei, Zhou, Chiara, Ambrogio, Asim K, Bera, Qing, Li, Xing-Xiao, Li, Lianbo, Li, Jieun, Son, Sudershan, Gondi, Jiaqi, Li, Emily, Campbell, Hua, Jin, Jeffrey J, Okoro, Cheng-Xiong, Xu, Pasi A, Janne, and Kenneth D, Westover
- Subjects
Proto-Oncogene Proteins p21(ras) ,Mice ,HEK293 Cells ,Lung Neoplasms ,MAP Kinase Signaling System ,Carcinoma, Non-Small-Cell Lung ,Mutation ,Animals ,Heterografts ,Humans ,Female ,raf Kinases - Abstract
Assembly of RAS molecules into complexes at the cell membrane is critical for RAS signaling. We previously showed that oncogenic KRAS codon 61 mutations increase its affinity for RAF, raising the possibility that KRAS
- Published
- 2020
25. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor
- Author
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Jamie A. Saxon, Michael J. Eck, Pasi A. Jänne, T. Kosaka, Jieun Son, Eun Young Park, Hwan Geun Choi, Nathanael S. Gray, Dries De Clercq, Jaebong Jang, and Junko Tanizaki
- Subjects
0301 basic medicine ,Lung Neoplasms ,Receptor, ErbB-2 ,Afatinib ,Mutant ,Biology ,medicine.disease_cause ,Article ,Catalysis ,03 medical and health sciences ,Exon ,0302 clinical medicine ,Cell Line, Tumor ,medicine ,Humans ,Epidermal growth factor receptor ,Protein Kinase Inhibitors ,Cell Proliferation ,Mutation ,Wild type ,Exons ,General Medicine ,General Chemistry ,Activating mutation ,ErbB Receptors ,Fluorobenzenes ,Molecular Docking Simulation ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Signal transduction ,medicine.drug - Abstract
Exon 20 insertion (Ex20Ins) mutations are the third most prevalent epidermal growth factor receptor (EGFR) activating mutation and the most prevalent HER2 mutation in non-small cell lung cancer (NSCLC). Novel therapeutics for the patients with Ex20Ins mutations are urgently needed, due to their poor responses to the currently approved EGFR and HER2 inhibitors. Here we report the discovery of highly potent and broadly effective EGFR and HER2 Ex20Ins mutant inhibitors. The co-crystal structure of compound 1 b in complex with wild type EGFR clearly revealed an additional hydrophobic interaction of 4-fluorobenzene ring within a deep hydrophobic pocket, which has not been widely exploited in the development of EGFR and HER2 inhibitors. As compared with afatinib, compound 1 a exhibited superior inhibition of proliferation and signaling pathways in Ba/F3 cells harboring either EGFR or HER2 Ex20Ins mutations, and in the EGFR P772_H773insPNP patient-derived lung cancer cell line DFCI127. Our study identifies promising strategies for development of EGFR and HER2 Ex20Ins mutant inhibitors.
- Published
- 2018
26. Epithelial oestrogen receptor α is dispensable for the development of oestrogen-induced cervical neoplastic diseases
- Author
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Jieun Son, Sang-Hyuk Chung, and Yuri Park
- Subjects
0301 basic medicine ,Genetically modified mouse ,chemistry.chemical_classification ,Stromal cell ,Biology ,medicine.disease ,Cervical intraepithelial neoplasia ,Epithelium ,Pathology and Forensic Medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,chemistry ,Stroma ,030220 oncology & carcinogenesis ,Keratin ,Carcinoma ,medicine ,Cancer research ,Estrogen receptor alpha - Abstract
Human papillomavirus (HPV) is required but not sufficient for cervical carcinoma (CxCa) development. Oestradiol (E2 ) promotes CxCa development in K14E7 transgenic mice expressing the HPV16 E7 oncoprotein under the control of the keratin (K14) promoter. E2 mainly functions through oestrogen receptor α (ERα). However, the role of ERα in human CxCa has been underappreciated largely because it is not expressed in carcinoma cells. We have shown that deletion of Esr1 (the ERα-coding gene) in the cervical stroma of K14E7 mice promotes regression of cervical intraepithelial neoplasia (CIN), the precursor lesion of CxCa. Here, we deleted Esr1 in the cervical epithelium but not in the stroma. We found that E2 induced cervical epithelial cell proliferation in epithelial ERα-deficient mice. We also found that E2 promoted the development of CIN and CxCa in epithelial ERα-deficient K14E7 mice and that all neoplastic epithelial cells were negative for ERα. In addition, proliferation indices were similar between ERα- and ERα+ CxCa. These results indicate that epithelial ERα is not necessary for E2 -induced CIN and CxCa. Taking these findings together, we conclude that stromal ERα rather than epithelial ERα mediates oncogenic E2 signalling in CxCa. Our results support stromal ERα signalling as a therapeutic target for the disease. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
- Published
- 2018
27. Academic paper recommender system using multilevel simultaneous citation networks
- Author
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Jieun Son and Seoung Bum Kim
- Subjects
Matching (statistics) ,Information Systems and Management ,Information retrieval ,Computer science ,Process (engineering) ,Scopus ,02 engineering and technology ,Recommender system ,Management Information Systems ,Arts and Humanities (miscellaneous) ,Content analysis ,Citation analysis ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Developmental and Educational Psychology ,020201 artificial intelligence & image processing ,Citation ,Information Systems - Abstract
Researchers typically need to filter several academic papers to find those relevant to their research. This filtering is cumbersome and time-consuming because the number of published academic papers is growing exponentially. Some researchers have focused on developing better recommender systems for academic papers by using citation analysis and content analysis. Most traditional content analysis is implemented using a keyword matching process, and thus it cannot consider the semantic contexts of items. Further, citation analysis-based techniques rely on the number of links directly citing or being cited in a single-level network. Consequently, it may be difficult to recommend the appropriate papers when the paper of interest does not have enough citation information. To address these problems, we propose a recommendation system for academic papers that combines citation analysis and network analysis. The proposed method is based on multilevel citation networks that compare all the indirectly linked papers to the paper of interest to inspect the structural and semantic relationships among them. Thus, the proposed method tends to recommend informative and useful papers related to both the research topic and the academic theory. The comparison results based on real data showed that the proposed method outperformed the Google Scholar and SCOPUS algorithms.
- Published
- 2018
28. Content-based filtering for recommendation systems using multiattribute networks
- Author
-
Seoung Bum Kim and Jieun Son
- Subjects
Computer science ,General Engineering ,02 engineering and technology ,Recommender system ,computer.software_genre ,MovieLens ,Computer Science Applications ,Cold start ,Artificial Intelligence ,Robustness (computer science) ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Data mining ,Cluster analysis ,Centrality ,computer - Abstract
We propose a content-based filtering algorithm based on a multiattribute network.Network analysis can consider similarities among indirectly-connected items.The proposed method addresses the data sparsity and over-specialization problems.The experiment with MovieLens demonstrates the robustness of the proposed method. Content-based filtering (CBF), one of the most successful recommendation techniques, is based on correlations between contents. CBF uses item information, represented as attributes, to calculate the similarities between items. In this study, we propose a novel CBF method that uses a multiattribute network to effectively reflect several attributes when calculating correlations to recommend items to users. In the network analysis, we measure the similarities between directly and indirectly linked items. Moreover, our proposed method employs centrality and clustering techniques to consider the mutual relationships among items, as well as determine the structural patterns of these interactions. This mechanism ensures that a variety of items are recommended to the user, which improves the performance. We compared the proposed approach with existing approaches using MovieLens data, and found that our approach outperformed existing methods in terms of accuracy and robustness. Our proposed method can address the sparsity problem and over-specialization problem that frequently affect recommender systems. Furthermore, the proposed method depends only on ratings data obtained from a user's own past information, and so it is not affected by the cold start problem.
- Published
- 2017
29. Causal Relationships in the Balanced Scorecard for Public Sector Organizations: A Focus on the Customer and Financial Perspectives of the Korean Airports Corporation
- Author
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Sooncheol Ghwon, Jieun Son, and Soonae Park
- Subjects
Finance ,Focus (computing) ,Balanced scorecard ,Granger causality analysis ,Performance management ,business.industry ,Public sector ,General Earth and Planetary Sciences ,Customer perspective ,Business ,Corporation ,General Environmental Science - Published
- 2017
30. Synthesis of TiO2 nanotubes using different alkaline media and their applications in photocatalysis and DSSCs
- Author
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Gobinda Gyawali, Soo Wohn Lee, Nguyen Huy Hao, Sunghun Cho, Tae-Ho Kim, and Jieun Son
- Subjects
Materials science ,Aqueous solution ,Nanostructure ,Diffuse reflectance infrared fourier transform ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Hydrothermal circulation ,0104 chemical sciences ,Dye-sensitized solar cell ,Chemical engineering ,Transmission electron microscopy ,Photocatalysis ,0210 nano-technology ,Absorption (electromagnetic radiation) - Abstract
TiO2 nanotubes (TNTs) were successfully synthesized from different alkaline media (i.e., NaOH and KOH) by using a microwave hydrothermal process. The effects of different alkaline media on the formation of TiO2 nanotubes and their physicochemical properties were investigated. The phases of different TiO2 nanostructures were studied by using X-ray diffraction patterns. Morphologies of the nanostructures were observed with a transmission electron microscope. The optical properties of the nanostructures were evaluated through the absorption behavior using UV–Vis diffuse reflectance spectroscopy. The photocatalytic activities of the TiO2 nanostructures were evaluated by the degradation of methylene blue aqueous dye solution under the simulated solar light irradiation. Similarly, the photovoltaic efficiencies of the prepared samples were investigated by making photo-anode layers in the Dye Sensitized Solar Cells (DSSCs). The results revealed that in comparison to the single layered TiO2 nanostructures in the DSSC, creation of a double layer structure significantly enhanced the efficiency of DSSC.
- Published
- 2017
31. Generating Color from Polydisperse, Near Micron-Sized TiO2 Particles
- Author
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Dong Ha Kim, Jerome K. Hyun, Al-Mahmnur Alam, Yi Rong Pei, Jin-Ho Choy, Jieun Son, and Kyungnae Baek
- Subjects
Materials science ,Scattering ,business.industry ,Mie scattering ,Dispersity ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Light scattering ,0104 chemical sciences ,Optics ,Extinction (optical mineralogy) ,Particle-size distribution ,Light scattering by particles ,Particle ,General Materials Science ,0210 nano-technology ,business - Abstract
Single particle Mie calculations of near micron-sized TiO2 particles predict strong light scattering dominating the visible range that would give rise to a white appearance. We demonstrate that a polydisperse collection of these “white” particles can result in the generation of visible colors through ensemble scattering. The weighted averaging of the scattering over the particle size distribution modifies the sharp, multiple, high order scattering modes from individual particles into broad variations in the collective extinction. These extinction variations are apparent as visible colors for particles suspended in organic solvent at low concentration, or for a monolayer of particles supported on a transparent substrate viewed in front of a white light source. We further exploit the color variations on optical sensitivity to the surrounding environment to promote micron-sized TiO2 particles as stable and robust agents for detecting the optical index of homogeneous media with high contrast sensitivities. Su...
- Published
- 2017
32. Active-Material-Independent Color-Tunable Semitransparent Organic Solar Cells
- Author
-
Kyungkon Kim, Youngji Kim, Jieun Son, Shafidah Shafian, and Jerome K. Hyun
- Subjects
Materials science ,Organic solar cell ,business.industry ,Photovoltaic system ,02 engineering and technology ,Dielectric ,010402 general chemistry ,021001 nanoscience & nanotechnology ,USable ,01 natural sciences ,0104 chemical sciences ,Colored ,Color gel ,Electrode ,Optoelectronics ,General Materials Science ,0210 nano-technology ,business - Abstract
Semitransparent colorful organic solar cells (OSC) provide exciting opportunities for harnessing sunlight as colored windows. Previously, color filter (CF) electrodes on (OSC) were demonstrated via vacuum-deposition techniques, resulting in deposition-induced damage. Thus, we present CF integrated organic photovoltaics (CF-OPVs) using solution-processed TiO2-AcAc as the dielectric component. The noninvasive processing substantially expands the range of usable active materials, allowing the device to display pure and vibrant colors that are independent of the inherent color of the active material and show superior optical and photovoltaic characteristics. These results provide practical pathways to realizing colored semitransparent solar cells.
- Published
- 2019
33. Optimal Piecewise Polynomial Approximation for Minimum Computing Cost by Using Constrained Least Squares
- Author
-
Jieun Song and Bumjoo Lee
- Subjects
piecewise polynomial ,function approximation ,regression ,constrained least squares ,Chemical technology ,TP1-1185 - Abstract
In this paper, the optimal approximation algorithm is proposed to simplify non-linear functions and/or discrete data as piecewise polynomials by using the constrained least squares. In time-sensitive applications or in embedded systems with limited resources, the runtime of the approximate function is as crucial as its accuracy. The proposed algorithm searches for the optimal piecewise polynomial (OPP) with the minimum computational cost while ensuring that the error is below a specified threshold. This was accomplished by using smooth piecewise polynomials with optimal order and numbers of intervals. The computational cost only depended on polynomial complexity, i.e., the order and the number of intervals at runtime function call. In previous studies, the user had to decide one or all of the orders and the number of intervals. In contrast, the OPP approximation algorithm determines both of them. For the optimal approximation, computational costs for all the possible combinations of piecewise polynomials were calculated and tabulated in ascending order for the specific target CPU off-line. Each combination was optimized through constrained least squares and the random selection method for the given sample points. Afterward, whether the approximation error was below the predetermined value was examined. When the error was permissible, the combination was selected as the optimal approximation, or the next combination was examined. To verify the performance, several representative functions were examined and analyzed.
- Published
- 2024
- Full Text
- View/download PDF
34. Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus
- Author
-
Fabiola F. Mehta, Sang-Hyuk Chung, John P. Lydon, Jieun Son, Kenneth S. Korach, Eunjung Jang, and Sylvia C. Hewitt
- Subjects
0301 basic medicine ,Stromal cell ,mouse model ,Uterus ,Estrogen receptor ,Mice, Transgenic ,Cervix Uteri ,Biology ,progesterone receptor ,Epithelium ,Andrology ,Mice ,03 medical and health sciences ,Downregulation and upregulation ,Pathology Section ,Progesterone receptor ,medicine ,Animals ,Cervix ,female reproductive tract ,estrogen receptor α ,Cell Differentiation ,Research Paper: Pathology ,3. Good health ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Nuclear receptor ,Vagina ,Immunology ,Female ,Receptors, Progesterone - Abstract
// Fabiola F. Mehta 1 , Jieun Son 1 , Sylvia C. Hewitt 2 , Eunjung Jang 1 , John P. Lydon 3 , Kenneth S. Korach 2 and Sang-Hyuk Chung 1 1 Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA 2 Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA 3 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA Correspondence to: Sang-Hyuk Chung, email: // Keywords : progesterone receptor, estrogen receptor α, epithelium, female reproductive tract, mouse model, Pathology Section Received : August 04, 2015 Accepted : March 02, 2016 Published : March 17, 2016 Abstract While the function of progesterone receptor (PR) has been studied in the mouse vagina and uterus, its regulation and function in the cervix has not been described. We selectively deleted epithelial PR in the female reproductive tracts using the Cre/LoxP recombination system. We found that epithelial PR was required for induction of apoptosis and suppression of cell proliferation by progesterone (P 4 ) in the cervical and vaginal epithelium. We also found that epithelial PR was dispensable for P 4 to suppress apoptosis and proliferation in the uterine epithelium. PR is encoded by the Pgr gene, which is regulated by estrogen receptor α (ERα) in the female reproductive tracts. Using knock−in mouse models expressing ERα mutants, we determined that the DNA−binding domain (DBD) and AF2 domain of ERα were required for upregulation of Pgr in the cervix and vagina as well as the uterine stroma. The ERα AF1 domain was required for upregulation of Pgr in the vaginal stroma and epithelium and cervical epithelium, but not in the uterine and cervical stroma. ERα DBD, AF1, and AF2 were required for suppression of Pgr in the uterine epithelium, which was mediated by stromal ERα. Epithelial ERα was responsible for upregulation of epithelial Pgr in the cervix and vagina. Our results indicate that regulation and functions of epithelial PR are different in the cervix, vagina, and uterus.
- Published
- 2016
35. Gold recovery using porphyrin-based polymer from electronic wastes: Gold desorption and adsorbent regeneration
- Author
-
Yeongran Hong, Jong-In Han, Cafer T. Yavuz, Jieun Son, Thien S. Nguyen, and Gyeol Han
- Subjects
chemistry.chemical_classification ,Environmental Engineering ,Materials science ,010504 meteorology & atmospheric sciences ,Infrared spectroscopy ,Polymer ,010501 environmental sciences ,01 natural sciences ,Pollution ,Porphyrin ,chemistry.chemical_compound ,Adsorption ,chemistry ,Thiourea ,Chemical engineering ,Desorption ,Reagent ,Environmental Chemistry ,Leaching (metallurgy) ,Waste Management and Disposal ,0105 earth and related environmental sciences - Abstract
Electronic wastes containing precious metals have great potential as a sustainable source of such metals. Separation and refining, however, remain complicated, and none of the existing technologies have yet experienced commercialization. A novel porphyrin-based porous polymer, named COP-180, was recently introduced as a powerful adsorbent option, especially for gold, and in this study, aspects of desorption and recovery of adsorbed gold and regeneration of the polymer were investigated. A hydrometallurgical method using non-cyanide leaching agents was developed, and an acid thiourea-based solution was found to be particularly suited for the method based on COP-180 with gold desorption efficiency of 97%. Fourier-transform infrared spectroscopy spectra demonstrated the unaffected structure of COP-180 after desorption, implying the potential of its reuse. This high desorption efficiency was achieved even without typical aiding agents by means of a formamidine disulfide-mediated route that prevented thiourea consumption, which is considered a major drawback of the otherwise promising reagent. Using this method, the polymer was able to maintain more than 94% desorption efficiency after five times of regeneration. The results suggest that acid thiourea can offer a workable means of recovering gold particularly from the excellent gold-adsorbent of COP-180, and that repeated regeneration is also possible.
- Published
- 2020
36. Achievements of the performance evaluation of public institutions
- Author
-
Soonae Park, Jieun Son, and Youngmi Lee
- Subjects
Political science ,Public institution ,Public administration - Published
- 2018
37. Semitransparent and colorful organic solar cells using Fabry-Perot optical filters as electrodes (Conference Presentation)
- Author
-
Kyungkon Kim, Youngji Kim, Jerome K. Hyun, Shafidah Shafian, and Jieun Son
- Subjects
Presentation ,Materials science ,Organic solar cell ,business.industry ,media_common.quotation_subject ,Electrode ,Optoelectronics ,Optical filter ,business ,Fabry–Pérot interferometer ,media_common - Published
- 2018
38. Review and Analysis of Recommender Systems
- Author
-
Hyun-Joong Kim, Jieun Son, Sungzoon Cho, and Seoung Bum Kim
- Subjects
World Wide Web ,Set (abstract data type) ,Information retrieval ,Computer science ,Collaborative filtering ,Recommender system - Abstract
The explosive growth of the world-wide-web and the emergence of e-commerce has led to the development of recommender systems. Recommender systems are personalized information filtering used to identify a set of items that will be of interest to a certain user. This paper reviews recommender systems and presents their pros and cons. †
- Published
- 2015
39. Epithelial oestrogen receptor α is dispensable for the development of oestrogen-induced cervical neoplastic diseases
- Author
-
Jieun, Son, Yuri, Park, and Sang-Hyuk, Chung
- Subjects
Mice, Knockout ,Estradiol ,Ovariectomy ,Estrogen Receptor alpha ,Keratin-14 ,Uterine Cervical Neoplasms ,Cell Differentiation ,Epithelial Cells ,Oncogene Proteins, Viral ,Uterine Cervical Dysplasia ,Article ,Repressor Proteins ,Wnt Proteins ,Disease Models, Animal ,Cell Transformation, Neoplastic ,Animals ,Female ,Stromal Cells ,Promoter Regions, Genetic ,Cell Proliferation ,Signal Transduction - Abstract
Human papillomavirus (HPV) is required but not sufficient for cervical carcinoma (CxCa). Estradiol (E(2)) promotes CxCa development in K14E7 transgenic mice expressing the HPV16 E7 oncoprotein under the control of the keratin 14 (K14) promoter. E(2) mainly works through estrogen receptor α (ERα). However, the role of ERα in human CxCa has been underappreciated largely because it is not expressed in carcinoma cells. We have shown that deletion of Esr1 (the ERα-coding gene) in the cervical stroma of K14E7 mice promotes regression of cervical intraepithelial neoplasia (CIN), the precursor lesion of CxCa. Here, we deleted Esr1 in the cervical epithelium but not stroma. We found that E(2) induced cervical epithelial cell proliferation in epithelial ERα-deficient mice. We also found that E(2) promoted the development of CIN and CxCa in epithelial ERα-deficient K14E7 mice, and all neoplastic epithelial cells were negative for ERα. In addition, proliferation indices were similar between ERα(−) and ERα(+) CxCa. These results indicate that epithelial ERα is not necessary for E(2)-induced CIN and CxCa. Taken together, we conclude that stromal ERα, rather than epithelial ERα, mediates oncogenic E(2) signaling in CxCa. Our results support stromal ERα signaling as a therapeutic target for the disease.
- Published
- 2017
40. Generating Color from Polydisperse, Near Micron-Sized TiO
- Author
-
Al-Mahmnur, Alam, Kyungnae, Baek, Jieun, Son, Yi-Rong, Pei, Dong Ha, Kim, Jin-Ho, Choy, and Jerome K, Hyun
- Abstract
Single particle Mie calculations of near micron-sized TiO
- Published
- 2017
41. Microalgae dewatering based on forward osmosis employing proton exchange membrane
- Author
-
Mina Sung, Hoyoung Ryu, Jong-In Han, Jieun Son, and You-Kwan Oh
- Subjects
Osmosis ,Environmental Engineering ,020209 energy ,Forward osmosis ,Proton exchange membrane fuel cell ,Flux ,Biomass ,Bioengineering ,Portable water purification ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Water Purification ,chemistry.chemical_compound ,0202 electrical engineering, electronic engineering, information engineering ,Microalgae ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Environmental engineering ,Membranes, Artificial ,General Medicine ,Pulp and paper industry ,Dewatering ,Chlorophyll ,Protons - Abstract
In this study, electrically-facilitated forward osmosis (FO) employing proton exchange membrane (PEM) was established for the purpose of microalgae dewatering. An increase in water flux was observed when an external voltage was applied to the FO equipped with the PEM; as expected, the trend became more dramatic with both concentration of draw solution and applied voltage raised. With this FO used for microalgae dewatering, 247% of increase in flux and 86% in final biomass concentration were observed. In addition to the effect on flux improvement, the electrically-facilitated FO exhibited the ability to remove chlorophyll from the dewatered biomass, down to 0.021±0015mg/g cell. All these suggest that the newly suggested electrically-facilitated FO, one particularly employed PEM, can indeed offer a workable way of dewatering of microalgae; it appeared to be so because it can also remove the ever-problematic chlorophyll from extracted lipids in a simultaneous fashion.
- Published
- 2017
42. Rule Selection Method in Decision Tree Models
- Author
-
Seoung Bum Kim and Jieun Son
- Subjects
Incremental decision tree ,business.industry ,Computer science ,Decision tree learning ,Decision tree ,ID3 algorithm ,Pattern recognition ,Machine learning ,computer.software_genre ,Alternating decision tree ,Influence diagram ,Decision stump ,Artificial intelligence ,Selection method ,business ,computer - Published
- 2014
43. Metal sulfides as anode catalysts in direct alkaline sulfide fuel cell
- Author
-
Kwiyong Kim, Jong-In Han, and Jieun Son
- Subjects
chemistry.chemical_classification ,Sulfide ,Renewable Energy, Sustainability and the Environment ,Hydrogen sulfide ,Inorganic chemistry ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Condensed Matter Physics ,Electrochemistry ,Sulfur ,Catalysis ,Anode ,Metal ,chemistry.chemical_compound ,Fuel Technology ,chemistry ,visual_art ,visual_art.visual_art_medium ,Cyclic voltammetry - Abstract
Effective, stable, and economical anode catalysts are prerequisite for the practical use of a promising sulfide-based fuel cell platform, named direct alkaline sulfide fuel cell (DASFC). In this study, metal sulfides (MeS, Me = Mo, Fe, Co) were investigated as potential candidates suited for such a purpose. Physical and electrochemical properties of MeS catalysts were measured using X-ray diffraction (XRD), cyclic voltammetry (CV), I–V analysis, and electrochemical impedance spectrophotometry (EIS). All MeS catalysts exhibited strong catalytic activity toward sulfide oxidation at alkaline conditions, with the highest performance observed with CoS, recording maximum power density of 29.18 mW cm−2 at 70 °C. MeS catalysts, with superb sulfur tolerance, appear to be potent anode catalysts for the DASFC application.
- Published
- 2014
44. Electrochemical reduction of CO2 on Ag/MnO2 binary catalyst
- Author
-
Ki Rak Lee, Jong-In Han, Jieun Son, and Dongsu Song
- Subjects
Materials science ,Electrolytic cell ,Scanning electron microscope ,Process Chemistry and Technology ,chemistry.chemical_element ,02 engineering and technology ,Manganese ,010501 environmental sciences ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Pollution ,Electron transport chain ,Catalysis ,chemistry ,Chemical Engineering (miscellaneous) ,Cyclic voltammetry ,0210 nano-technology ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Electrochemical reduction of carbon dioxide ,Nuclear chemistry - Abstract
Ag and γ-MnO2 binary catalyst was tested as a cathode catalyst candidate for carbon dioxide reduction reaction in electrolytic cell. Prepared γ-MnO2 was characterized by X-ray diffraction (XRD) and a field-emission scanning electron microscope (SEM). The electrocatalytic activity of Ag/γ-MnO2 binary catalyst toward CO2 reduction was investigated by cyclic voltammetry (CV). The results of CV measurement indicated that Ag/γ-MnO2 containing 10 wt% of silver was found to have a higher catalytic activity than carbon-supported 10 wt% Ag and improve catalytic performance as much as that of 50 wt% of carbon-supported Ag. The suggested binary catalyst with low content of Ag had a substantial improvement in catalytic activity. It is anticipated manganese dioxide plays a crucial role in electron transport and stabilization of intermediate enhancing multiple electron participation in reduction process. This result, along with its exceedingly low cost, thus suggests that γ-MnO2 is indeed a promising co-catalyst toward CO2 reduction.
- Published
- 2019
45. Abstract 1732: Switch to MET oncogene dependence as a novel mechanism of drug resistance in EGFR-mutant lung cancer
- Author
-
Man Xu, Prafulla C. Gokhale, Pasi A. Jänne, Jihyun Choi, George Q. Daley, Heidi M. Haikala, Michael J. Poitras, Pavlos Missios, Pinar O. Eser, Stephen Wang, Raymond M. Paranal, Atsuko Ogino, Masahiko Yanagita, Jieun Son, and Mika Lin
- Subjects
Cancer Research ,biology ,Crizotinib ,business.industry ,Cancer ,medicine.disease ,Oncology ,medicine ,Cancer research ,biology.protein ,Osimertinib ,ERBB3 ,Epidermal growth factor receptor ,Erlotinib ,business ,Lung cancer ,medicine.drug ,EGFR inhibitors - Abstract
Introduction: Non-small cell lung cancers harboring sensitizing gain-of-function mutations in the epidermal growth factor receptor (EGFR) are treated with small molecule EGFR kinase inhibitors including erlotinib and osimertinib. Unfortunately, the clinical efficacy of these inhibitors is limited by progression to drug resistance. Genomic amplification of the hepatocyte growth factor receptor (MET) is a prevalent mechanism of resistance to clinical EGFR inhibitors. EGFR mutant lung cancers with MET amplification are co-dependent on signaling through EGFR and MET kinases, whereby either oncogene can phosphorylate the EGFR family receptor ERBB3, activating downstream signaling and promoting survival. These EGFR/MET co-dependent cancers are characteristically resistant to treatment with individual drugs, but retain sensitivity to combination treatment with EGFR and MET inhibitors. Here, we describe three patient-derived EGFR mutant, MET amplified lung cancer models that exhibit a switch away from EGFR, to MET oncogene dependence. Methods: We established and characterized patient-derived lung cancer cell lines and xenograft models harboring concurrent EGFR activating mutations (EGFR L858R or EGFR Del19) and genomic MET copy number gain. Three patient-derived models—DFCI81, DFCI161, and DFCI307—were developed from pleural effusion and core biopsy specimens of patients whose tumors progressed on erlotinib. Clinical samples were immediately sorted and stably cultured in vitro or engrafted into immunodeficient mice. Results: DFCI81, DFCI161, and DFCI307 cell lines and xenograft models retained mutant EGFR expression, but exhibited resistance to clinical EGFR inhibitors and sensitivity to single-agent c-MET inhibitors, including crizotinib and savolitinib. Comparing our EGFR-mutant and MET-dependent cell lines to EGFR/MET-codependent models, we observed that EGFR expression was significantly reduced in our models compared to controls. Ectopic overexpression of EGFR Del19 and EGFR L858R in DFCI81 and DFCI161 cell lines, respectively, was sufficient to confer crizotinib resistance and induce EGFR/MET co-dependency. We demonstrated that MET-mediated ERBB3 phosphorylation drives downstream PI3K activation to promote cell proliferation and survival in DFCI81 and DFCI161 cells. In these contexts, ERBB3 reactivation by recombinant ligand treatment was sufficient to induce EGFR-mediated ERBB3 activation, conferring resistance to single-agent crizotinib treatment. Conclusions: We have identified and characterized three patient-derived models of treatment refractory EGFR mutant lung cancer that exhibit a switch to MET oncogene dependency. Clinically, we predict a subset of EGFR mutant, MET-dependent tumors exists, and can be identified de novo by a reduced EGFR to MET expression ratio: a potential biomarker predictive of sensitivity to single-agent MET inhibition. Citation Format: Pinar Ö. Eser, Raymond M. Paranal, Michael J. Poitras, Man Xu, Stephen Wang, Atsuko Ogino, Jihyun Choi, Pavlos Missios, Heidi M. Haikala, Jieun Son, Mika Lin, Masahiko Yanagita, Prafulla C. Gokhale, George Q. Daley, Pasi A. Jänne. Switch to MET oncogene dependence as a novel mechanism of drug resistance in EGFR-mutant lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1732.
- Published
- 2019
46. cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction
- Author
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Zang Hee Lee, Jong Ho Lee, Ha-Neui Kim, Jieun Son, and Hyunil Ha
- Subjects
Histology ,Physiology ,Endocrinology, Diabetes and Metabolism ,Biophysics ,Mice, Nude ,Bone Neoplasms ,Breast Neoplasms ,Osteolysis ,Matrix metalloproteinase ,CREB ,Biochemistry ,Mice ,Breast cancer ,Downregulation and upregulation ,Transforming Growth Factor beta ,Cell Line, Tumor ,Gene expression ,medicine ,Animals ,Humans ,Insulin-Like Growth Factor I ,Neoplasm Metastasis ,Cyclic AMP Response Element-Binding Protein ,Molecular Biology ,Regulation of gene expression ,biology ,business.industry ,Interleukin-17 ,Osteoprotegerin ,Parathyroid Hormone-Related Protein ,Bone metastasis ,Cancer ,Cell Biology ,medicine.disease ,Xenograft Model Antitumor Assays ,Matrix Metalloproteinases ,Gene Expression Regulation, Neoplastic ,Cell culture ,Cancer cell ,Cancer research ,biology.protein ,Female ,business - Abstract
cAMP-response-element-binding protein (CREB) signaling has been reported to be associated with cancer development and poor clinical outcome in various types of cancer. However, it remains to be elucidated whether CREB is involved in breast cancer development and osteotropism. Here, we found that metastatic MDA-MB-231 breast cancer cells exhibited higher CREB expression than did non-metastatic MCF-7 cells and that CREB expression was further increased by several soluble factors linked to cancer progression, such as IL-1, IGF-1, and TGF-beta. Using wild-type CREB and a dominant-negative form (K-CREB), we found that CREB signaling positively regulated the proliferation, migration, and invasion of MDA-MB-231 cells. In addition, K-CREB prevented MDA-MB-231 cell-induced osteolytic lesions in a mouse model of cancer metastasis. Furthermore, CREB signaling in cancer cells regulated the gene expression of PTHrP, MMPs, and OPG, which are closely involved in cancer metastasis and bone destruction. These results indicate that breast cancer cells acquire CREB overexpression during their development and that this CREB upregulation plays an important role in multiple steps of breast cancer bone metastasis.
- Published
- 2010
47. Abstract B28: Development of estrogen-dependent and estrogen receptor-negative cervical cancer in HPV transgenic mice
- Author
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Jieun Son and Sang-Hyuk Chung
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Cervical cancer ,Cancer Research ,Stromal cell ,business.industry ,medicine.drug_class ,Estrogen receptor ,Cancer ,medicine.disease ,medicine.anatomical_structure ,Oncology ,Stroma ,Estrogen ,Cancer research ,Medicine ,business ,Estrogen receptor alpha ,Cervix - Abstract
Estradiol (E2) and human papillomavirus (HPV) cooperate to cause cervical cancer. The role of estrogen receptor α (ERα) in cervical cancer has been underappreciated. Chronic treatment with E2 promotes the development of cervical cancer in K14E7 transgenic mice expressing HPV16 E7 oncoprotein. In the present study, we bred K14E7 to mice with conditional ablation of Esr1 (ERα-coding gene) in the cervical epithelial cells (Wnt7aCre/Esr1f/f; Esr1ed/ed). We found that E2 promoted the development of ERα cervical cancer in K14E7/Esr1ed/ed mice. In addition, proliferation and apoptotic indices of ERα cancer in K14E7/Esr1ed/ed mice were similar to those of ERα+ cancer in K14E7/Esr1f/f mice. We also found that E2 increased the epithelium thickness and epithelial cell proliferation in the cervix of Esr1ed/ed mice. Our published results have demonstrated that deletion of Esr1 in the cervical stroma promotes the regression of cervical precancer lesions in K14E7 mice. In patients, ERα is expressed in the cancer stroma but not cancer epithelial cells. These observations support that stromal ERα, rather than epithelial ERα, mainly mediates oncogenic E2 signaling for cervical cancer. They also suggest that stromal ERα might be an effective therapeutic target for cervical cancer. Note: This abstract was not presented at the conference. Citation Format: Jieun Son, Sang-Hyuk Chung. Development of estrogen-dependent and estrogen receptor-negative cervical cancer in HPV transgenic mice [abstract]. In: Proceedings of the AACR Special Conference: Advances in Modeling Cancer in Mice: Technology, Biology, and Beyond; 2017 Sep 24-27; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(10 Suppl):Abstract nr B28.
- Published
- 2018
48. Semitransparent Blue, Green, and Red Organic Solar Cells Using Color Filtering Electrodes
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Youngji Kim, Jieun Son, Shafidah Shafian, Kyungkon Kim, and Jerome K. Hyun
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Materials science ,Organic solar cell ,business.industry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Color gel ,Electrode ,Optoelectronics ,Building-integrated photovoltaics ,0210 nano-technology ,business - Published
- 2018
49. Acoustic correlates of perceived personality from Korean utterances in a formal communicative setting.
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Jieun Song, Minjeong Kim, and Jaehan Park
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Medicine ,Science - Abstract
The aim of the present study was to find acoustic correlates of perceived personality from the speech produced in a formal communicative setting-that of Korean customer service employees in particular. This work extended previous research on voice personality impressions to a different sociocultural and linguistic context in which speakers are expected to speak politely in a formal register. To use naturally produced speech rather than read speech, we devised a new method that successfully elicited spontaneous speech from speakers who were role-playing as customer service employees, while controlling for the words and sentence structures they used. We then examined a wide range of acoustic properties in the utterances, including voice quality and global acoustic and segmental properties using Principal Component Analysis. Subjects of the personality rating task listened to the utterances and rated perceived personality in terms of the Big-Five personality traits. While replicating some previous findings, we discovered several acoustic variables that exclusively accounted for the personality judgments of female speakers; a more modal voice quality increased perceived conscientiousness and neuroticism, and less dispersed formants reflecting a larger body size increased the perceived levels of extraversion and openness. These biases in personality perception likely reflect gender and occupation-related stereotypes that exist in South Korea. Our findings can also serve as a basis for developing and evaluating synthetic speech for Voice Assistant applications in future studies.
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- 2023
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50. Childhood abuse and opioid prescription use in adulthood: Differences between non-Hispanic Whites and non-Hispanic Blacks in the United States.
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Hee Yun Lee, Jieun Song, and Eun Young Choi
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Medicine ,Science - Abstract
Despite the rapid rise in opioid prescription medication usage, little research has examined the role of early life adversity, such as childhood abuse, particularly in the context of race, in opioid prescription usage in adulthood. Guided by the life course perspective, the current study investigates whether experiencing childhood abuse increases the risk of opioid prescription use in adulthood and whether this association varies by race. Data were sourced from the second wave of the Midlife in the United States (MIDUS) study (2004-2005). The analytic sample consisted of two groups: non-Hispanic Whites (n = 714) and non-Hispanic Blacks (n = 151). Opioid prescription use was identified from the participants' medication list using the MULTUM Lexicon Drug Database Classification System. Three types of childhood abuse-emotional, physical, and sexual-were assessed via summary scales derived from the Childhood Trauma Questionnaire. The results indicate a significant interaction between childhood physical abuse and race. Among non-Hispanic Whites, higher exposure to physical abuse during childhood was associated with greater odds of opioid prescription use in adulthood, even after adjusting for chronic pain, physical and mental health, and sociodemographic characteristics. However, the association between childhood physical abuse and opioid prescription use in adulthood was non-significant among non-Hispanic Black individuals. These findings underscore the long-term adverse health effects of physical abuse in childhood, particularly for non-Hispanic Whites, and suggest support for developing and implementing tailored intervention strategies.
- Published
- 2023
- Full Text
- View/download PDF
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