160 results on '"Jie Ae Kim"'
Search Results
2. The impact of pulmonary function tests on early postoperative complications in open lung resection surgery: an observational cohort study
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Ji Won Choi, Heejoon Jeong, Hyun Joo Ahn, Mikyung Yang, Jie Ae Kim, Duk Kyung Kim, Sang Hyun Lee, Keoungah Kim, and Jisun Choi
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Medicine ,Science - Abstract
Abstract We investigated whether pulmonary function tests (PFTs) can predict pulmonary complications and if they are, to find new cutoff values in current open lung resection surgery. In this observational study, patients underwent open lung resection surgery at a tertiary hospital were analyzed (n = 1544). Various PFTs were tested by area under the receiver-operating characteristic curve (AUCROC) to predict pulmonary complications until 30 days postoperatively. In results, PFTs were generally not effective to predict pulmonary complications (AUCROC: 0.58–0.66). Therefore, we could not determine new cutoff values, and used previously reported cutoffs for post-hoc analysis [predicted postoperative forced expiratory volume in one second (ppoFEV1) 40%. In conclusion, PFTs themselves were not effective predictors of pulmonary complications. Decision to proceed with surgical resection of lung cancer should be made on an individual basis considering other risk factors and the patient's goals.
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- 2022
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3. Driving pressure guided ventilation
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Hyun Joo Ahn, MiHye Park, Jie Ae Kim, Mikyung Yang, Susie Yoon, Bo Rim Kim, Jae-Hyon Bahk, Young Jun Oh, and Eun-Ho Lee
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driving pressure ,positive end-expiratory pressure ,postoperative complications ,protective ventilation ,Anesthesiology ,RD78.3-87.3 - Abstract
Protective ventilation is a prevailing ventilatory strategy these days and is comprised of small tidal volume, limited inspiratory pressure, and application of positive end-expiratory pressure (PEEP). However, several retrospective studies recently suggested that tidal volume, inspiratory pressure, and PEEP are not related to patient outcomes, or only related when they influence the driving pressure. Therefore, this review introduces the concept of driving pressure and looks into the possibility of driving pressure-guided ventilation as a new ventilatory strategy, especially in thoracic surgery where postoperative pulmonary complications are common, and thus, lung protection is of utmost importance.
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- 2020
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4. Safety of Rigid Bronchoscopy for Therapeutic Intervention at the Intensive Care Unit Bedside
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Sang Hyuk Kim, Boksoon Chang, Hyun Joo Ahn, Jie Ae Kim, Mikyung Yang, Hojoong Kim, and Byeong-Ho Jeong
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rigid bronchoscopy ,intensive care unit ,complications ,Medicine (General) ,R5-920 - Abstract
Background and Objective: Although rigid bronchoscopy is generally performed in the operating room (OR), the intervention is sometimes emergently required at the intensive care unit (ICU) bedside. The aim of this study is to evaluate the safety of rigid bronchoscopy at the ICU bedside. Materials and Methods: We retrospectively analyzed medical records of patients who underwent rigid bronchoscopy while in the ICU from January 2014 to December 2020. According to the location of rigid bronchoscopic intervention, patients were classified into the ICU group (n = 171, cases emergently performed at the ICU bedside without anesthesiologists) and the OR group (n = 165, cases electively performed in the OR with anesthesiologists). The risk of intra- and post-procedural complications in the ICU group was analyzed using multivariable logistic regression, with the OR group as the reference category. Results: Of 336 patients, 175 (52.1%) were moribund and survival was not expected without intervention, and 170 (50.6%) received invasive respiratory support before the intervention. The most common reasons for intervention were post-intubation tracheal stenosis (39.3%) and malignant airway obstruction (34.5%). Although the overall rate of intra-procedural complications did not differ between the two groups (86.0% vs. 80.6%, p = 0.188), post-procedural complications were more frequent in the ICU group than in the OR group (24.0% vs. 12.1%, p = 0.005). Severe complications requiring unexpected invasive management occurred only post-procedurally and were more common in the ICU group (10.5% vs. 4.8%, p = 0.052). In the fully adjusted model, the ICU group had increased odds for severe post-procedural complications, but statistical significance was not observed (odds ratio, 2.54; 95% confidence interval, 0.73–8.88; p = 0.144). Conclusions: Although general anesthesia is generally considered the gold standard for rigid bronchoscopy, our findings indicate that rigid bronchoscopy may be safely performed at the ICU bedside in selective cases of emergency. Moreover, adequate patient selection and close post-procedural monitoring are required to prevent severe complications.
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- 2022
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5. Whole-lung lavage complicated with pneumothorax: a case report
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Hyun-Joo Ahn, Mikyung Yang, Jie Ae Kim, Burnyoung Heo, Jin-Kyoung Kim, and So Yoon Park
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bronchoalveolar lavage ,pneumothorax ,pulmonary alveolar proteinosis ,Anesthesiology ,RD78.3-87.3 - Abstract
A patient with pulmonary alveolar proteinosis underwent whole lung lavage of the right lung. Lavage of the left lung was not immediately possible because of severe hypoxemia. Three days later, after correction of hypoxemia, we re-attempted the left lung lavage. However, the patient had severe hypoxemia (SpO2 < 80%) within a few minutes of performing right one lung ventilation (OLV). On bronchoscopic examination, proper tube location was confirmed. Bronchodilator nebulization and steroid injection were attempted with no effect. While searching for the cause of the hypoxemia, we found that the breath sound from the right lung had become very weak and distant compared with that from initial auscultation. Right pneumothorax was diagnosed on chest X-ray and a chest tube was inserted. After confirming pneumothorax resolution, we re-tried right OLV and were able to proceed with the left lung lavage without signs of aggravating air leak, loss of tidal volume, or severe hypoxemia.
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- 2017
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6. Comparison of respiratory mechanics between sevoflurane and propofol-remifentanil anesthesia for laparoscopic colectomy
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Si Ra Bang, Sang Eun Lee, Hyun Joo Ahn, Jie Ae Kim, Byung Seop Shin, Hee Jin Roe, and Woo Seog Sim
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laparoscopy ,propofol ,remifentanil ,respiratory mechanics ,sevoflurane ,Anesthesiology ,RD78.3-87.3 - Abstract
BackgroundThe creation of pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery are associated with respiratory changes. We aimed to compare respiratory mechanics while using intravenous propofol and remifentanil vs. sevoflurane during laparoscopic colectomy.MethodsSixty patients undergoing laparoscopic colectomy were randomly allocated to one of the two groups: group PR (propofol-remifentanil group; n = 30), and group S (sevoflurane group; n = 30). Peak inspiratory pressure (PIP), dynamic lung compliance (Cdyn), and respiratory resistance (Rrs) values at five different time points: 5 minutes after induction of anesthesia (supine position, T1), 3 minutes after pneumoperitoneum (lithotomy position, T2), 3 minutes after pneumoperitoneum while in the lithotomy-Trendelenburg position (T3), 30 minutes after pneumoperitoneum (T4), and 3 minutes after deflation of pneumoperitoneum (T5).ResultsIn both groups, there were significant increases in PIP and Rrs while Cdyn decreased at times T2, T3, and T4 compared to T1 (P < 0.001). The Rrs of group PR for T2, T3, and T4 were significantly higher than those measured in group S for the corresponding time points (P < 0.05).ConclusionsRespiratory mechanics can be adversely affected during laparoscopic colectomy. Respiratory resistance was significantly higher during propofol-remifentanil anesthesia than sevoflurane anesthesia.
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- 2014
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7. Respiratory insufficiency and dynamic hyperinflation after rigid bronchoscopy in a patient with relapsing polychondritis -a case report
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Hyun-Joo Ahn, Jie Ae Kim, Mikyung Yang, and Eun Kyung Lee
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acquired subglottic stenosis ,bronchoscopy ,relapsing polychondritis ,respiratory insufficiency ,tracheobronchomalacia ,Anesthesiology ,RD78.3-87.3 - Abstract
Relapsing polychondritis (RP) is an uncommon disease that is characterized by inflammation and destruction of cartilaginous structures. When tracheobronchial tree is involved, respiratory obstructive symptoms can occur. A 35-year-old man, with a previous diagnosis of RP, was scheduled for rigid bronchoscopy to relieve dyspnea, caused by subglottic stenosis. After laser splitting of the subglottic web, the spontaneous respiration of the patient was insufficient, and hypercarbia developed progressively even with assisted ventilation. After 20 minutes of aggressive hyperventilation to reduce end-tidal CO2 level, sudden extreme tachycardia and hypotension developed. Ventilation rate was reduced and prolonged expiration time was allowed to alleviate a near-tampon status from dynamic hyperinflation. After the hemodynamic status was stabilized, the patient was transferred to the ICU for mechanical ventilation. He received ICU care for 30 days, and now, he was on supportive care on a ward, considering Y stent insertion to prevent luminal collapse from tracheobronchomalacia.
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- 2013
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8. Risk score for postoperative complications in thoracic surgery
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Mikyung Yang, Hyun-Joo Ahn, Jie Ae Kim, and Jae-Myung Yu
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postoperative complications ,risk scores ,thoracic surgery ,Anesthesiology ,RD78.3-87.3 - Abstract
BackgroundRisk scoring system for thoracic surgery patients have not been widely used, as of recently. We tried to forge a risk scoring system that predicts the risk of postoperative complications in patients undergoing major thoracic surgery. We used a prolonged ICU stay as a representative of postoperative complications and tested various possible risk factors for its relation.MethodsData from all patients who underwent major lung and esophageal cancer surgeries, between 2005 and 2007 in our hospital, were collected retrospectively (n = 858). Multiple logistic regression analysis was performed with various possible risk factors to build the risk scoring system for prolonged ICU stay (> 3 days).ResultsA total of 9% of patients exhibited more than 3 days of ICU stay. Age, operation name, preoperative lung injury, no epidural analgesia, and predicted post operative forced expiratory volume in 1 second (ppoFEV1) were the risk factors for prolonged ICU stay, by multivariable analysis (P < 0.05). Risk score, p was derived from the formula: logit(p/[1-p]) = -5.39 + 0.06 × age + 1.12 × operation name(2) + 1.52 × operation name(3) + 1.32 × operation name(4) + 1.56 × operation name(5) + 1.30 × preoperative lung injury + 0.72 × no epidural analgesia - 0.02 × ppoFEV1 [Age in years, operation name(2): pneumonectomy, operation name(3): esophageal cancer operation, operation name(4): completion pneumonectomy, operation name(5): extended operation, preoperative lung injury(+), epidural analgesia(-), ppoFEV1 in %].ConclusionsAge, operation name, preoperative lung injury, epidural analgesia, and ppoFEV1 can predict postoperative morbidity in thoracic surgery patients.
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- 2012
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9. Postoperative nausea and vomiting after endoscopic thyroidectomy: total intravenous vs. balanced anesthesia
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Gunn Hee Kim, Hyun Joo Ahn, Hyun-Soo Kim, Si Ra Bang, Hyun-Sung Cho, Mikyung Yang, and Jie Ae Kim
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endoscopic surgery ,ponv ,thyroidectomy ,Anesthesiology ,RD78.3-87.3 - Abstract
BackgroundEndoscopic thyroidectomy was recently introduced and has been rapidly accepted by surgeons and patients. The present study was conducted to estimate and compare the incidences of postoperative nausea and vomiting (PONV) after endoscopic thyroidectomy using two different anesthetic methods: sevoflurane based balanced anesthesia; total intravenous anesthesia (TIVA).MethodsNinety nine female patients that were scheduled to undergo elective endoscopic thyroidectomy under general anesthesia were enrolled. These patients were randomly allocated to receive sevoflurane based balanced anesthesia (BA group) or propofol-remifentanil anesthesia (TIVA group). PONV was evaluated using a 4-point Likert scale, and pain using a visual analogue scale (VAS; range 0 to 100) for 0-2, 2-6, and 6-24 hours postoperatively. At 24 hours postoperatively, overall patient satisfaction regarding PONV and pain were recorded.ResultsThe incidence of PONV was 14.6% in the TIVA group and 51.3% in the BA group. The incidence of nausea at 0-2 and 2-6 hours postoperatively was lower in the TIVA group than in the BA group (4.2% vs. 35.9%, 6.3% vs. 23.1%, respectively), but no between-group difference was observed at 6-24 hours postoperatively (8.3% vs. 5.1%). Antiemetic usage at 0-2 and 2-6 hours was lower in the TIVA than the BA group (4.2% vs. 38.5%, 6.3% vs. 23.1%), but no between-group difference was observed for 6-24 hours (6.3% vs. 7.7%). There were no differences in pain or in patient satisfaction.ConclusionsAfter endoscopic thyroidectomy, total intravenous anesthesia with propofol-remifentanil is associated with less PONV during the early postoperative period (0-6 hours) than sevoflurane based balanced anesthesia.
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- 2011
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10. Interactions of propofol and remifentanil on bispectral index under 66% NO: analysis by dose-effect curve, isobologram, and combination index
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Won Ho Kim, Hyun Joo Ahn, and Jie Ae Kim
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bispectral index ,isobologram ,propofol ,remifentanil ,synergies ,Anesthesiology ,RD78.3-87.3 - Abstract
BackgroundPropofol and remifentanil are usually co-administered and have shown synergistic effect for anesthesia. However, the synergistic effect of the two drugs on hypnosis measured by bispectral index (BIS) was controversial in previous studies. The aim of this study was to identify the interaction of propofol and remifentanil on BIS and the optimal dose combinations for hypnosis under 66% N2O during surgery.MethodsPatients (age 55-75 and American Society of Anesthesiologists [ASA] 1-2) undergoing gastrectomy were enrolled in this study. Propofol and remifentanil were co-administered incrementally at 1 : 1 potent ratio (the P1R1 group), at 1 : 2 potent ratio (the P1R2 group), or at 2 : 1 potent ratio (the P2R1 group) using effect site target-controlled infusion and BIS was measured. 66% N2O was concomitantly administered to all groups. The dose-effect curves, the 90% effective dose (EC90) for adequate hypnosis (BIS 40), isobolograms and combination index were obtained by Calcusyn program (Biosoft) to reveal the interaction of propofol and remifentanil.ResultsThe P2R1 group showed synergistic action on BIS. However, the other groups needed larger amount of each drug than the doses of additive action. The EC90 of the P2R1 group was propofol, 3.34 µg/ml and remifentanil, 2.41 ng/ml under 66% of N2O.ConclusionsPropofol dominant co-administration is needed for dose reduction in BIS guided hypnosis.
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- 2010
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11. Comparison of the effectiveness of lidocaine and salbutamol on coughing provoked by intravenous remifentanil during anesthesia induction
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Si-Ra Bang, Hyun Joo Ahn, Hyo Jin Kim, Gunn Hee Kim, Jie Ae Kim, Mikyung Yang, Jin-Kyoung Kim, and Hyun-Sung Cho
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cough ,lidocaine ,remifentanil ,salbutamol ,Anesthesiology ,RD78.3-87.3 - Abstract
BackgroundCoughing is a side effect of opioids that is rarely studied. Here, we evaluated the incidence of remifentanil induced coughing during anesthesia induction in an attempt to identify its risk factors and to examine the preventive effects of lidocaine and salbutamol.MethodsA total of 237 patients scheduled to undergo general anesthesia were allocated randomly into three groups. Group C received no medication, while Group L received 2% lidocaine at 0.5 mg/kg intravenously 1 minute prior to remifentanil infusion and Group S inhaled one metered aerosol puff of salbutamol 15 minutes prior to entering the operating room. Remifentanil was infused at 5 ng/ml by target controlled infusion and coughing was measured for five minutes and graded as none, mild, moderate, or severe based on the number of coughs.ResultsThe incidences of coughing were 30.4%, 25.3%, and 35.4% in Groups C, L, and S, respectively. The incidences, onset times, and severity of coughing did not differ significantly among groups. In addition, multivariate analysis showed that non-smoking and a lower body weight were risk factors of remifentanil-induced coughing (odds ratio, 8.13; P = 0.024, 1.11, and 0.004, respectively).ConclusionsThe incidence of remifentanil-induced coughing was 30%. A total of 0.5 mg/kg lidocaine and 1 metered aerosol puff of salbutamol did not prevent coughing. Non-smoking and low body weight were found to be risk factors of remifentanil-induced coughing.
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- 2010
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12. Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation?
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Jeong Jin Lee, Jie Ae Kim, Hyun Joo Ahn, Jin-Kyoung Kim, Mikyung Yang, Soo Joo Choi, Hyun-Soo Kim, and Soo Hyun Yang
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bis ,intubation ,nicardipine ,nimodipine ,Anesthesiology ,RD78.3-87.3 - Abstract
BackgroundTheoretically, L-type calcium channel blockers could modulate anesthetic effects. Nicardipine does not affect the bispectral index (BIS), but nimodipine, which can penetrate the blood-brain barrier, has not been studied. The aim of this study was to evaluate whether a single dose of intravenous nicardipine or nimodipine could affect BIS following rapid sequence intubation.MethodsThis study was done in a double-blind, randomized fashion. Anesthesia was induced with fentanyl 2 µg/kg, thiopental sodium 5 mg/kg, and 100% oxygen. After loss of consciousness, patients received rocuronium 1.0 mg/kg and either a bolus of 20 µg/kg nicardipine, nimodipine, or a comparable volume of normal saline (n = 20). Intubation was performed 1 min after study drug administration. BIS, mean blood pressure (MBP), and heart rate (HR) were measured before anesthetic induction, after loss of consciousness, before intubation, during intubation, and 1, 2 and 5 min after intubation.ResultsBIS dropped rapidly after induction but increased to 60 before intubation in all groups irrespective of study drug. In nimodipine, the increase in BIS during intubation was not significant compared to pre-intubation, in contrast to the other two groups, but there was no difference in BIS during intubation. HR significantly increased, but MBP just rose to pre-induction values after intubation in nicardipine and nimodipine groups. BIS, MBP, and HR following intubation increased in control group.ConclusionsA single dose of intravenous nicardipine or nimodipine could attenuate blood pressure increases but not affect BIS increases in rapid sequence intubation.
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- 2010
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13. Obesity is independently associated with spinal anesthesia outcomes: a prospective observational study.
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Hyo-Jin Kim, Won Ho Kim, Hyung Woo Lim, Jie Ae Kim, Duk-Kyung Kim, Byung Seop Shin, Woo Seog Sim, Tae Soo Hahm, Chung Su Kim, and Sangmin M Lee
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Medicine ,Science - Abstract
The influence of body-mass index (BMI) on spinal anesthesia is still controversial, with discrepant results reported in previous studies. To compare spinal anesthesia in obese and non-obese subjects, the anesthesia profiles in patients who underwent spinal anesthesia using intrathecal hyperbaric bupivacaine were compared. A total of 209 patients undergoing elective total knee replacement arthroplasty (TKRA) surgery under spinal anesthesia were divided into an NO (non-obese) group (BMI < 30 kg/m2, n = 141) and an O (obese) group (BMI ≥ 30 kg/m2, n = 68). Anesthesia was deemed successful if a bilateral T12 sensory block occurred within 15 minutes of intrathecal drug administration, and if the level of sensory block was higher than T12 when the surgery ended. Logistic regression analysis with multiple variables known to influence spinal anesthesia was performed to identify which parameters independently determined the spinal anesthesia outcome. Similar doses of bupivacaine were administered to the NO and O groups. The incidence of anesthesia failure was significantly lower in the O group [n = 43 (30.5%) in the NO group vs. n = 10 (18.9%) in the O group, p = 0.014]. The independent predictors for successful anesthesia in all patients were dose of hyperbaric bupivacaine [odds ratio (OR) 2.12, 95% CI: 1.64-2.73] and obese status (BMI ≥ 30 kg/m2, OR 2.86, 95% CI: 1.25-6.52). Time to first report of postoperative pain and time to first self-void were significantly longer in the O group. These results suggest that the duration of block with hyperbaric bupivacaine is prolonged in obese patients and obesity is independently associated with spinal anesthesia outcomes, as is bupivacaine dosage. A further study enrolling patients with morbid obesity and using a fixed bupivacaine dosage is required to confirm the effect of obesity on spinal anesthesia.
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- 2015
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14. Transient bilateral vocal cord paralysis after endotracheal intubation with double-lumen tube -A case report
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Dae Myoung Jeong, Gunn Hee Kim, Jie Ae Kim, and Sangmin Maria Lee
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bilateral vocal cord paralysis ,double-lumen endotracheal tube ,postoperative stridor ,Anesthesiology ,RD78.3-87.3 - Abstract
Vocal cord paralysis is one of the most serious anesthetic complications related to endotracheal intubation. The practitioner should take extreme care, as bilateral vocal cord paralysis can obstruct the airway and lead to disastrous respiratory problems. There have been many papers on bilateral vocal cord paralysis after neck surgery, but reports on such a condition after lung surgery are very rare. We report a case of bilateral vocal cord paralysis detected after removal of a double-lumen endotracheal tube in a 67-year-old patient who underwent wedge resection by video-assisted thoracoscopic surgery. We also note that he recovered spontaneously without complications within a day.
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- 2010
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15. The use of the Clarus Video System for double-lumen endobronchial tube intubation in a patient with a difficult airway
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Young Ri Kim, Byung Hui Jun, and Jie Ae Kim
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Anesthesiology ,RD78.3-87.3 - Published
- 2013
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16. Effect of Sevoflurane Anesthesia on Diastolic Function: A Prospective Observational Study.
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Sang Hyun Lee, Hyun Joo Ahn, Gyeong Min Kim, MiKyung Yang, Jie Ae Kim, Lee, Sangmin M., Burn Young Heo, Ji Won Choi, Jin Young Lee, Heejoon Jeong, and Jeayoun Kim
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- 2024
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17. Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery: a multicentre randomised clinical trial
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MiHye Park, Susie Yoon, Jae-Sik Nam, Hyun Joo Ahn, Heezoo Kim, Hye Jin Kim, Hoon Choi, Hong Kwan Kim, Randal S. Blank, Sung-Cheol Yun, Dong Kyu Lee, Mikyung Yang, Jie Ae Kim, Insun Song, Bo Rim Kim, Jae-Hyon Bahk, Juyoun Kim, Sangho Lee, In-Cheol Choi, Young Jun Oh, Wonjung Hwang, Byung Gun Lim, and Burn Young Heo
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Anesthesiology and Pain Medicine - Published
- 2023
18. Pressure Support versus Spontaneous Ventilation during Anesthetic Emergence—Effect on Postoperative Atelectasis: A Randomized Controlled Trial
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Hyean Yeo, Pisitpitayasaree Tanatporn, Mikyung Yang, Hyun Joo Ahn, Woojin Kim, Jie Ae Kim, and Heejoon Jeong
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Male ,Laparoscopic surgery ,Pulmonary Atelectasis ,medicine.medical_treatment ,Trendelenburg position ,Pressure support ventilation ,Atelectasis ,Anesthesia, General ,Pacu ,law.invention ,Positive-Pressure Respiration ,Postoperative Complications ,Double-Blind Method ,law ,Pressure ,medicine ,Humans ,Prospective Studies ,Aged ,Mechanical ventilation ,biology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,biology.organism_classification ,medicine.disease ,Respiration, Artificial ,Intensive care unit ,Pulse oximetry ,Anesthesiology and Pain Medicine ,Oxygen Saturation ,Anesthesia ,Anesthesia Recovery Period ,Female ,business - Abstract
Background Despite previous reports suggesting that pressure support ventilation facilitates weaning from mechanical ventilation in the intensive care unit, few studies have assessed its effects on recovery from anesthesia. The authors hypothesized that pressure support ventilation during emergence from anesthesia reduces postoperative atelectasis in patients undergoing laparoscopic surgery using the Trendelenburg position. Methods In this randomized controlled double-blinded trial, adult patients undergoing laparoscopic colectomy or robot-assisted prostatectomy were assigned to either the pressure support (n = 50) or the control group (n = 50). During emergence (from the end of surgery to extubation), pressure support ventilation was used in the pressure support group versus intermittent manual assistance in the control group. The primary outcome was the incidence of atelectasis diagnosed by lung ultrasonography at the postanesthesia care unit (PACU). The secondary outcomes were Pao2 at PACU and oxygen saturation measured by pulse oximetry less than 92% during 48 h postoperatively. Results Ninety-seven patients were included in the analysis. The duration of emergence was 9 min and 8 min in the pressure support and control groups, respectively. The incidence of atelectasis at PACU was lower in the pressure support group compared to that in the control group (pressure support vs. control, 16 of 48 [33%] vs. 28 of 49 [57%]; risk ratio, 0.58; 95% CI, 0.35 to 0.91; P = 0.024). In the PACU, Pao2 in the pressure support group was higher than that in the control group (92 ± 26 mmHg vs. 83 ± 13 mmHg; P = 0.034). The incidence of oxygen saturation measured by pulse oximetry less than 92% during 48 h postoperatively was not different between the groups (9 of 48 [19%] vs. 11 of 49 [22%]; P = 0.653). There were no adverse events related to the study protocol. Conclusions The incidence of postoperative atelectasis was lower in patients undergoing either laparoscopic colectomy or robot-assisted prostatectomy who received pressure support ventilation during emergence from general anesthesia compared to those receiving intermittent manual assistance. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New
- Published
- 2021
19. Comparison of Early and Late Surgeries after Coronary Stent Implantation in Patients with Normal Preoperative Troponin Level: A Retrospective Study
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Sang Hyun Lee, Eun Kyung Lee, Hyun Joo Ahn, Sangmin M. Lee, Jie Ae Kim, Mikyung Yang, Ji Won Choi, Jeayoun Kim, Heejoon Jeong, Seungmo Kim, Jinseo Kim, and Joonghyun Ahn
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coronary stents ,noncardiac surgery ,troponin I ,stent to surgery time interval ,General Medicine - Abstract
Current guidelines recommend delaying noncardiac surgery for 6 months after drug eluting stent implantation. However, this recommendation is largely based on limited evidence and various event definitions. Whether early surgery within 6 months of coronary stent implantation increases myocardial injury in patients with normal preoperative high-sensitivity cardiac troponin I (hs-cTnI) has not yet been investigated. This retrospective study assessed patients who received coronary stent implantation and underwent noncardiac surgery (vascular, abdominal, or thoracic) between 2010 and 2017 with normal preoperative hs-cTnI (n = 186). Patients were divided into early (within 6 months of PCI) and late (after 6 months of PCI) groups. The primary endpoint was the incidence of myocardial injury as diagnosed by hs-cTnI within 3 days post-operation. The secondary outcomes were myocardial infarction, stent thrombosis, emergent coronary revascularization, major bleeding (bleeding requiring transfusion or intracranial bleeding), stroke, renal failure, heart failure, or death within 30 days post-operation. Inverse probability treatment weighting (IPTW) was carried out to adjust for the intergroup baseline differences. Myocardial injury occurred in 28.6% (8/28) and 27.8% (44/158) of the early and late groups, respectively, with no difference between groups (odds ratio [OR] 1.067, 95% confidence interval [CI] 0.404, 2.482; p = 0.886). Secondary outcomes did not differ between the groups. IPTW analysis also showed no differences in myocardial injury and secondary outcomes between the groups. In conclusion, early surgery within 6 months after coronary stent implantation did not increase the incidence of myocardial injury in patients with normal preoperative hs-cTnI.
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- 2023
20. Driving pressure guided ventilation
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Bo Rim Kim, Jae-Hyon Bahk, Hyun Joo Ahn, MiHye Park, Susie Yoon, Mikyung Yang, Jie Ae Kim, Eun-Ho Lee, and Young Jun Oh
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medicine.medical_specialty ,protective ventilation ,Review Article ,driving pressure ,law.invention ,Positive-Pressure Respiration ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,law ,Tidal Volume ,postoperative complications ,Humans ,Medicine ,Positive end-expiratory pressure ,Tidal volume ,Retrospective Studies ,Lung protection ,business.industry ,030208 emergency & critical care medicine ,Retrospective cohort study ,Thoracic Surgical Procedures ,respiratory system ,respiratory tract diseases ,Protective ventilation ,Anesthesiology and Pain Medicine ,Cardiothoracic surgery ,lcsh:Anesthesiology ,Anesthesia ,Ventilation (architecture) ,business ,circulatory and respiratory physiology ,positive end-expiratory pressure - Abstract
Protective ventilation is a prevailing ventilatory strategy these days and is comprised of small tidal volume, limited inspiratory pressure, and application of positive end-expiratory pressure (PEEP). However, several retrospective studies recently suggested that tidal volume, inspiratory pressure, and PEEP are not related to patient outcomes, or only related when they influence the driving pressure. Therefore, this review introduces the concept of driving pressure and looks into the possibility of driving pressure-guided ventilation as a new ventilatory strategy, especially in thoracic surgery where postoperative pulmonary complications are common, and thus, lung protection is of utmost importance.
- Published
- 2020
21. Association between intraoperative hypotension and postoperative myocardial injury in patients with prior coronary stents undergoing high-risk surgery: a retrospective study
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Young Ri Kim, Hyun Joo Ahn, Burnyoung Heo, Sang Hyun Lee, Mikyung Yang, Jie Ae Kim, Jaeni Jang, and Soohyun Ahn
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Inotrope ,medicine.medical_specialty ,medicine.medical_treatment ,Cohort Studies ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,030202 anesthesiology ,Anesthesiology ,Coronary stent ,medicine ,Humans ,Intraoperative Complications ,Retrospective Studies ,business.industry ,030208 emergency & critical care medicine ,Retrospective cohort study ,Vascular surgery ,Anesthesiology and Pain Medicine ,Blood pressure ,Mean blood pressure ,Cardiothoracic surgery ,Anesthesia ,Stents ,Hypotension ,business - Abstract
We conducted a single-center retrospective study to evaluate the effects of intraoperative hypotension (IOH) on postoperative myocardial injury during major noncardiac surgery in patients with prior coronary stents with preoperatively normal cardiac troponin I levels. Although IOH is assumed to increase the risk of postoperative myocardial injury in patients with prior coronary stents, the level and duration of hazardous low blood pressure have not been clarified. Of 2517 patients with prior coronary stents undergoing noncardiac surgery between January 2010 and March 2017, we analyzed 195 undergoing major surgery (vascular, abdominal, and thoracic surgery) who had a normal preoperative high-sensitivity cardiac troponin I (hs-cTnI) level and were followed up postoperatively within 3 days. Postoperative myocardial injury was defined as a hs-cTnI level greater than the 99th percentile reference value. Primary IOH exposure was defined as a decrease of ≥ 50%, 40%, or 30% from the preinduction mean blood pressure. Additional definition of IOH was absolute mean blood pressure
- Published
- 2020
22. Driving Pressure during Thoracic Surgery
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MiHye Park, Burn Young Heo, Sang Hyun Lee, Ji Won Choi, Yung Ri Kim, Soo Joo Choi, Jie Ae Kim, Mikyung Yang, Hyun Joo Ahn, Heejoon Jeong, and In Sun Song
- Subjects
medicine.medical_specialty ,Lung ,business.industry ,030208 emergency & critical care medicine ,Acute respiratory distress ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Randomized controlled trial ,030202 anesthesiology ,law ,Cardiothoracic surgery ,Anesthesia ,medicine ,In patient ,Prospective cohort study ,Airway ,business ,Positive end-expiratory pressure - Abstract
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Recently, several retrospective studies have suggested that pulmonary complication is related with driving pressure more than any other ventilatory parameter. Thus, the authors compared driving pressure–guided ventilation with conventional protective ventilation in thoracic surgery, where lung protection is of the utmost importance. The authors hypothesized that driving pressure–guided ventilation decreases postoperative pulmonary complications more than conventional protective ventilation. Methods In this double-blind, randomized, controlled study, 292 patients scheduled for elective thoracic surgery were included in the analysis. The protective ventilation group (n = 147) received conventional protective ventilation during one-lung ventilation: tidal volume 6 ml/kg of ideal body weight, positive end-expiratory pressure (PEEP) 5 cm H2O, and recruitment maneuver. The driving pressure group (n = 145) received the same tidal volume and recruitment, but with individualized PEEP which produces the lowest driving pressure (plateau pressure–PEEP) during one-lung ventilation. The primary outcome was postoperative pulmonary complications based on the Melbourne Group Scale (at least 4) until postoperative day 3. Results Melbourne Group Scale of at least 4 occurred in 8 of 145 patients (5.5%) in the driving pressure group, as compared with 18 of 147 (12.2%) in the protective ventilation group (P = 0.047, odds ratio 0.42; 95% CI, 0.18 to 0.99). The number of patients who developed pneumonia or acute respiratory distress syndrome was less in the driving pressure group than in the protective ventilation group (10/145 [6.9%] vs. 22/147 [15.0%], P = 0.028, odds ratio 0.42; 95% CI, 0.19 to 0.92). Conclusions Application of driving pressure–guided ventilation during one-lung ventilation was associated with a lower incidence of postoperative pulmonary complications compared with conventional protective ventilation in thoracic surgery.
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- 2019
23. Desflurane reduces intraoperative remifentanil requirements more than sevoflurane: comparison using surgical pleth index-guided analgesia
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Dongchan Ko, Woocheol Choi, Kyungyul Ryu, Sung Hyun Lee, and Jie Ae Kim
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Adult ,Male ,Minimum alveolar concentration ,Analgesic ,Remifentanil ,Sevoflurane ,Young Adult ,03 medical and health sciences ,Desflurane ,Consciousness Monitors ,0302 clinical medicine ,Pharmacokinetics ,030202 anesthesiology ,medicine ,Humans ,Prospective Studies ,Infusions, Intravenous ,Aged ,business.industry ,030208 emergency & critical care medicine ,Middle Aged ,Confidence interval ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Cholecystectomy, Laparoscopic ,Opioid ,Anesthesia ,Anesthetics, Inhalation ,Female ,Analgesia ,business ,Algorithms ,Anesthetics, Intravenous ,medicine.drug - Abstract
Background Sevoflurane and desflurane are widely used in balanced anaesthesia in combination with opioid analgesics. The opioid remifentanil is frequently chosen because of its extremely rapid pharmacokinetics. However, intraoperative high-dose remifentanil is associated with increased postoperative pain and rescue analgesic use owing to acute tolerance and opioid-induced hyperalgesia. This study aimed to compare intraoperative remifentanil requirements during equi-minimum alveolar concentration (MAC) sevoflurane and desflurane anaesthesia via surgical pleth index-guided remifentanil administration. Methods Eighty-two subjects undergoing laparoscopic cholecystectomy were randomly allocated to two groups receiving either sevoflurane (n=40) or desflurane (n=42). Anaesthesia was maintained with the assigned inhaled anaesthetics and remifentanil. End-tidal anaesthetic concentration was maintained at age-corrected 1.0 MAC, and remifentanil infusion was continuously adjusted to achieve a surgical pleth index of 20–50. Mean remifentanil infusion rate, which was the primary outcome of the study, was calculated as the total infused remifentanil dose per kg body weight per minute of total operative time. Results Mean remifentanil infusion rate [mean (standard deviation)] was significantly higher in the sevoflurane group than in the desflurane group [0.192 (0.064) vs. 0.099 (0.033) μg kg−1 min−1; difference, 0.093 (95% confidence interval, 0.071–0.115); P Conclusions During equi-MAC anaesthesia of 1.0 MAC, sevoflurane and desflurane did not show similar intraoperative remifentanil consumption under surgical pleth index-guided opioid administration. Further studies using other monitors with different measuring mechanisms are warranted to determine the cause of this difference. Clinical trial registration NCT02830243 ( ClinicalTrials.gov ).
- Published
- 2018
24. Restrictive intraoperative fluid management was associated with higher incidence of composite complications compared to less restrictive strategies in open thoracotomy: A retrospective cohort study
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Hyun Joo Ahn, Ah Ran Oh, J O Choi, and Jie Ae Kim
- Subjects
Male ,medicine.medical_specialty ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Postoperative Complications ,030202 anesthesiology ,Republic of Korea ,medicine ,Cutoff ,Humans ,lcsh:Science ,Retrospective Studies ,Multidisciplinary ,Intraoperative Care ,business.industry ,Incidence (epidemiology) ,Incidence ,lcsh:R ,Acute kidney injury ,Retrospective cohort study ,Odds ratio ,Acute Kidney Injury ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,Bonferroni correction ,Thoracotomy ,Oncology ,Risk factors ,Cardiothoracic surgery ,symbols ,Fluid Therapy ,lcsh:Q ,Female ,business - Abstract
Restrictive fluid management has been recommended for thoracic surgery. However, specific guidelines are lacking, and there is always concern regarding impairment of renal perfusion with a restrictive policy. The objective of this study was to find the net intraoperative fluid infusion rate which shows the lowest incidence of composite complications (either pulmonary complications or acute kidney injury) in open thoracotomy. We hypothesized that a certain range of infusion rate would decrease the composite complications within postoperative 30 days. All patients (n = 1,031) who underwent open thoracotomy at a tertiary care university hospital were included in this retrospective study. The time frame of fluid monitoring was from the start of operation to postoperative 24 hours. The cutoff value of the intraoperative net fluid amount was 4–5 ml.kg−1.h−1 according to the minimum p-value method, thus, patients were divided into Low (≤3 ml.kg−1.h−1), Cutoff (4–5 ml.kg−1.h−1) and High (≥6 ml.kg−1.h−1) groups. The Cutoff group showed the lowest composite complication rate (19%, 12%, and 13% in the Low, Cutoff, and High groups, respectively, P = 0.0283; Low vs. Cutoff, P = 0.0324, Bonferroni correction). Acute respiratory distress syndrome occurred least frequently in the Cutoff group (7%, 3%, and 6% for the Low, Cutoff, and High groups, respectively, P = 0.0467; Low vs. Cutoff, P = 0.0432, Bonferroni correction). In multivariable analysis, intraoperative net fluid infusion rate was associated with composite complications, and the Cutoff group decreased risk (odds ratio 0.54, 95% confidence interval: 0.35–0.81, P = 0.0035). In conclusion, maintaining intraoperative net fluid infusion at 4–5 ml.kg−1.h−1 was associated with better results in open thoracotomy, in terms of composite complications, compared to more restrictive fluid management.
- Published
- 2019
25. Hydroxyethyl starch is associated with early postoperative delirium in patients undergoing esophagectomy
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Hyun Joo Ahn, Sangmin Maria Lee, Dae Myung Jung, Mikyung Yang, Jie Ae Kim, Duck Kyung Kim, and Joo Hyun Park
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Lung Diseases ,Male ,Time Factors ,medicine.medical_treatment ,Plasma Substitutes ,030204 cardiovascular system & hematology ,Hydroxyethyl starch ,law.invention ,Hydroxyethyl Starch Derivatives ,Tertiary Care Centers ,0302 clinical medicine ,Risk Factors ,law ,030212 general & internal medicine ,Age Factors ,Middle Aged ,Intensive care unit ,Treatment Outcome ,Esophagectomy ,Anesthesia ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Antipsychotic Agents ,medicine.drug ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Serum Albumin, Human ,Risk Assessment ,03 medical and health sciences ,mental disorders ,medicine ,Humans ,Blood Transfusion ,Risk factor ,Aged ,Retrospective Studies ,business.industry ,Delirium ,Retrospective cohort study ,Crystalloid Solutions ,Odds ratio ,Perioperative ,Surgery ,Cerebrovascular Disorders ,Haloperidol ,business - Abstract
Objective Postoperative delirium is associated with longer hospital stay and increased morbidities. Patients undergoing esophagectomy have a high chance of developing postoperative delirium because of their advanced age, comorbidities, and intensive care unit care. In this study, we investigated the risk factors of early postoperative delirium in patients undergoing esophagectomy, focusing on perioperative fluid type to test the hypothesis that colloids with high oncotic pressure and anti-inflammatory action would decrease the incidence of postoperative delirium compared with crystalloids. Methods All patients who underwent esophagectomy from 2010 to 2015 in a tertiary care center were reviewed in this retrospective study (n = 1041). Patients who showed positive Confusion Assessment Method or received haloperidol within 4 days postoperatively were enrolled as those with postoperative delirium (+). Multivariable logistic regression was performed to identify risk factors for postoperative delirium. Incidence of postoperative delirium was compared among crystalloids, hydroxyethyl starch, and albumin groups after propensity score matching. Results The incidence of delirium within postoperative 4 days was 22.7%. Infusion of hydroxyethyl starch was an independent risk factor (odds ratio [OR], 1.53; 95% confidence interval [CI], 1.09-2.14; P = .0151). Other risk factors were age (OR, 1.04; 1.02-1.06, per year; P = .0002), preoperative cerebrovascular disease (OR, 2.18; 1.15-4.12; P = .0170), pulmonary dysfunction (OR, 1.85; 1.33-2.58; P = .0003), and transfusion (OR, 1.76; 1.22-2.53; P = .0023). Propensity score matching analysis confirmed that administration of hydroxyethyl starch, but not albumin, is related to postoperative delirium. Conclusions Old age, preoperative cerebrovascular disease, pulmonary dysfunction, transfusion, and hydroxyethyl starch administration were related to early postoperative delirium. If colloid must be administered, albumin is preferred to hydroxyethyl starch.
- Published
- 2018
26. Apneic oxygen insufflation decreases the incidence of hypoxemia during one-lung ventilation in open and thoracoscopic pulmonary lobectomy: A randomized controlled trial
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Su Min Shin, Jie Ae Kim, Mikyung Yang, Dae Myung Jung, Sin Ho Jung, Suyong Jeon, and Hyun Joo Ahn
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Male ,Pulmonary and Respiratory Medicine ,Insufflation ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Hypoxemia ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,030202 anesthesiology ,Hypoxic pulmonary vasoconstriction ,medicine ,Humans ,Prospective Studies ,Continuous positive airway pressure ,Hypoxia ,Intraoperative Complications ,Pneumonectomy ,business.industry ,Incidence ,Thoracoscopy ,Oxygenation ,Middle Aged ,One-Lung Ventilation ,respiratory tract diseases ,Oxygen ,Cardiothoracic surgery ,Anesthesia ,Breathing ,Arterial blood ,Female ,Surgery ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective Hypoxemia is common during one-lung ventilation (OLV) for thoracic surgery. When hypoxemia occurs, surgery is interrupted for rescue ventilation. Apneic oxygen insufflation (AOI), which provides O 2 without applying pressure, may prevent hypoxemia and does not interrupt surgery. The aim of this study was to determine the effectiveness of the AOI technique for preventing hypoxemia during OLV in thoracic surgery. Methods Patients undergoing open or thoracoscopic pulmonary lobectomy from September to December 2015 were included. Patients were assigned randomly to a non-AOI group or an AOI group (n = 45 each). OLV was initiated and at the 15-minute mark (OLV15), patients in the AOI group received oxygen insufflation at 3 L/min to the nonventilated lung for 30 minutes (OLV45). The primary endpoint was the occurrence of hypoxemia (SaO 2 Results The demographic and operative data were similar between the 2 groups. The incidence of hypoxemia was greater in the non-AOI than the AOI group (18% vs 0%; P = .009). ΔPaO 2 (the difference in partial pressure of oxygen in arterial blood between OLV 45 and 15 minutes) was smaller in the AOI than the non-AOI group (−29 mm Hg vs −69 mm Hg; P = .005). Duration of surgery and incidence of complications did not vary between groups. Conclusions AOI decreases the incidence of hypoxemia and improves arterial oxygenation during OLV for open and thoracoscopic surgery. AOI may be a valuable option to prevent hypoxemia. It can be used before relying on continuous positive airway pressure or intermittent two-lung ventilation and result in fewer interruptions in surgery.
- Published
- 2017
27. Decreased Incidence of Postoperative Delirium in Robot-assisted Thoracoscopic Esophagectomy Compared With Open Transthoracic Esophagectomy
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Mikyung Yang, Soo Hee Lee, Burn Young Heo, Hyun Joo Ahn, Dae Myoung Jeong, and Jie Ae Kim
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Male ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Operative Time ,law.invention ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,law ,Republic of Korea ,Humans ,Medicine ,Thoracoscopic esophagectomy ,030212 general & internal medicine ,Propensity Score ,Aged ,Retrospective Studies ,business.industry ,Incidence ,Thoracoscopy ,Incidence (epidemiology) ,Delirium ,Retrospective cohort study ,Robotics ,Odds ratio ,Length of Stay ,Intensive care unit ,Surgery ,Esophagectomy ,Thoracotomy ,030220 oncology & carcinogenesis ,Anesthesia ,Propensity score matching ,Female ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Background Postoperative delirium (POD) is one of messy complications related with increased mortality and hospital costs. Patients undergoing esophagectomy are more in danger of delirium than other kinds of surgeries. We investigated the impact of robot-assisted thoracoscopic esophagectomy on the incidence of POD compared with open transthoracic esophagectomy. Materials and methods A retrospective review was completed for the patients who underwent esophagectomy from December 2, 2012 and April 15, 2015 (n=529). POD was assessed using Confusion Assessment Method for the Intensive Care Unit. The comparison of group differences between the robotic esophagectomy group (R group) and the open esophagectomy group (O group) was conducted with and without propensity score (PS) matching method. Univariate model was used for 247 PS-matched patients to calculate the odds ratio of potential risk factors of POD. Results The incidence rate of POD was significantly lower among R group patients than O group (30% vs. 42%; P=0.035) after PS matching method. The risk of POD in R group was 0.55-fold lower than that of O group. Operative time and intraoperative blood loss were also significantly lower in R group patients. Conclusions In conclusion, robotic thoracoscopic esophagectomy lowers the incidence of POD 0.55-fold compared with open transthoracic esophagectomy.
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- 2016
28. The effect of preventive use of corticosteroids on postoperative complications after esophagectomy: A retrospective cohort study
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Duk Kyung Kim, Young Ri Kim, Ji Won Choi, Heejoon Jeong, Jin Kyoung Kim, Yong Soo Choi, Yoon Joo Chung, Mikyung Yang, Sang Hyun Lee, Hyun Joo Ahn, Byung Seop Shin, Jie Ae Kim, and MiHye Park
- Subjects
0301 basic medicine ,medicine.medical_specialty ,ARDS ,Esophageal Neoplasms ,medicine.medical_treatment ,lcsh:Medicine ,Dehiscence ,Article ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Adrenal Cortex Hormones ,Odds Ratio ,Clinical endpoint ,Humans ,Medicine ,lcsh:Science ,Propensity Score ,Aged ,Retrospective Studies ,Respiratory Distress Syndrome ,Multidisciplinary ,business.industry ,Oesophageal cancer ,Incidence ,Incidence (epidemiology) ,lcsh:R ,Retrospective cohort study ,Odds ratio ,Middle Aged ,medicine.disease ,Surgery ,Esophagectomy ,030104 developmental biology ,Risk factors ,Propensity score matching ,lcsh:Q ,business ,030217 neurology & neurosurgery - Abstract
Corticosteroids have been empirically administered to reduce the rate of acute respiratory distress syndrome (ARDS) after esophagectomy. However, their efficacy remains controversial, and corticosteroids may increase the risk of graft dehiscence and infection, which are major concerns after esophagectomy. Therefore, we compared the incidence of composite complications (ARDS, graft dehiscence and infection) after esophagectomy between patients who received a preventive administration of corticosteroids and those who did not. All patients who underwent esophagectomy from 2010 to 2015 at a tertiary care university hospital were reviewed retrospectively (n = 980). Patients were divided into Steroid (n = 120) and Control (n = 860) groups based on the preventive administration of 100 mg hydrocortisone during surgery. The primary endpoint was the incidence of composite complications. The incidence of composite complications was not different between the Control and Steroid groups (17.4% vs. 21.7% respectively; P = 0.26). The incidence rates of complications in each category were not different between the Control and Steroid groups: ARDS (3.8% vs. 5.0%; P = 0.46), graft dehiscence (4.8% vs. 6.7%; P = 0.37), and infection (12.8% vs. 15.8%; P = 0.36). Propensity score matching revealed that composite complications (20.0% vs. 21.7%; P = 0.75), ARDS (4.3% vs. 5.2%; P = 0.76) and infection (16.5% vs. 15.7%; P = 0.86) were not different between the Control and Steroid group, but the incidence of graft dehiscence was higher in the Steroid group than in the Control group (0.9% vs. 7.0%; P = 0.0175). In conclusions, the preventive use of corticosteroids did not reduce the incidence of ARDS, but may be related to an increased incidence of graft dehiscence. Therefore, routine administration of corticosteroids to prevent ARDS is not recommended in esophagectomy.
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- 2019
29. The effect of preventive use of corticosteroids on postoperative complications after esophagectomy: A retrospective cohort study
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Heejoon Jeong, Ji Won Choi, Hyun Joo Ahn, Jie Ae Kim, Mikyung Yang, Jin Kyoung Kim, Mihye Park, Duk Kyung Kim, Byung Seop Shin, Sang Hyun Lee, Young Ri Kim, and Yoon Joo Chung
- Abstract
Background: Although corticosteroids were known to reduce acute respiratory distress syndrome (ARDS) after esophagectomy, the efficacy of corticosteroid remains debatable. Moreover, the risk of anastomosis leakage or infection, which relates to the administration of corticosteroid is another concern. Therefore, we compared the incidence of composite complications between patients who received or not the preventive administration of corticosteroid in esophagectomy. Methods: All patients who underwent esophagectomy from 2010 to 2015 at a tertiary care university hospital, were reviewed in this retrospective study (n=1,041). Patients were divided into Steroid (n=120) and Control (n=860) groups based on the preventive administration of corticosteroid during surgery. The primary endpoint was the incidence of composite complications (acute respiratory distress syndrome, wound dehiscence, and infection). Comparison between the two groups was performed after adjustment of co-variables. Results: The incidence of composite complications was not different between Steroid and Control group (21.7% vs 17.4%, respectively; P=0.26). Incidence of complications in each category between Steroid and Control groups were not significantly different: acute respiratory distress syndrome (5.0% vs 3.8%; P=0.46), graft dehiscence (6.7% vs 4.8%; P=0.37), and infection (15.8% vs 12.8%; P=0.36). After propensity score matching, the difference between the groups was also not significant. In multivariable analysis, age, lower body mass index, diabetes mellitus and duration of operation were independent risk factors of composite complications. Additionally, intraoperative vasopressor was a risk factor of graft dehiscence (odds ratio, 2.06; 95% confidence interval, 1.03-4.12; P=0.0407). Conclusions: The preventive use of corticosteroid was not related to the incidence of composite complications after esophagectomy. Application of corticosteroid for prevention of acute respiratory distress syndrome is not recommended due to its lack of apparent benefit. Keywords: Acute respiratory distress syndrome, corticosteroid, esophagectomy.
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- 2019
30. Exposure of isoflurane-treated cells to hyperoxia decreases cell viability and activates the mitochondrial apoptotic pathway
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Gunn Hee Kim, Jie Ae Kim, Min Kyung Kim, Jeong Jin Lee, Hyun Sung Cho, Sang Hyun Lee, and Yang Hoon Chung
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Time Factors ,Cell Survival ,Apoptosis ,Hyperoxia ,PC12 Cells ,Statistics, Nonparametric ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,Bcl-2-associated X protein ,030202 anesthesiology ,In Situ Nick-End Labeling ,medicine ,Animals ,Viability assay ,Molecular Biology ,bcl-2-Associated X Protein ,chemistry.chemical_classification ,Reactive oxygen species ,TUNEL assay ,Isoflurane ,biology ,General Neuroscience ,Mitochondria ,Rats ,Proto-Oncogene Proteins c-bcl-2 ,Biochemistry ,chemistry ,Anesthetics, Inhalation ,biology.protein ,Apoptotic signaling pathway ,Neurology (clinical) ,medicine.symptom ,Reactive Oxygen Species ,030217 neurology & neurosurgery ,Signal Transduction ,Developmental Biology ,medicine.drug - Abstract
Isoflurane has either neuroprotective or neurotoxic effects. High-dose oxygen is frequently used throughout the perioperative period. We hypothesized that hyperoxia will affect cell viability of rat pheochromocytoma (PC12) cells that were exposed to isoflurane and reactive oxygen species (ROS) may be involved. PC12 cells were exposed to 1.2% or 2.4% isoflurane for 6 or 24h respectively, and cell viability was evaluated. To investigate the effects of hyperoxia, PC12 cells were treated with 21%, 50%, or 95% oxygen and 2.4% isoflurane for 6h, and cell viability, TUNEL staining, ROS production, and expression of B-cell lymphoma 2 (BCL-2), BCL2-associated X protein (BAX), caspase-3 and beta-site APP cleaving enzyme (BACE) were measured. ROS involvement was evaluated using the ROS scavenger 2-mercaptopropiopylglycine (MPG). The viability of cells exposed to 2.4% isoflurane was lower than that of cells exposed to 1.2% isoflurane. Prolonged exposure (6h vs. 24h) to 2.4% isoflurane resulted in a profound reduction in cell viability. Treatment with 95% (but not 50%) oxygen enhanced the decrease in cell viability induced by 2.4% isoflurane alone. Levels of ROS, Bax, caspase-3 and BACE were increased, whereas expression of Bcl-2 was decreased, in cells treated with 95% oxygen plus 2.4% isoflurane compared with the control and 2.4% isoflurane plus air groups. MPG attenuated the effects of oxygen and isoflurane. In conclusion, isoflurane affects cell viability in a dose- and time-dependent manner. This effect is augmented by hyperoxia and may involve ROS, the mitochondrial apoptotic signaling pathway, and β-amyloid protein.
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- 2016
31. The prognostic nutritional index and postoperative complications after curative lung cancer resection: A retrospective cohort study
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Sukhee Park, Hyun Joo Ahn, Soo Jung Park, Jie Ae Kim, Mikyung Yang, and Jin Kyoung Kim
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Nutritional Status ,030204 cardiovascular system & hematology ,Gastroenterology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Pneumonectomy ,Lung cancer ,Aged ,Retrospective Studies ,Receiver operating characteristic ,business.industry ,Hazard ratio ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Pneumonia ,ROC Curve ,030228 respiratory system ,Cardiothoracic surgery ,Propensity score matching ,Adenocarcinoma ,Female ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
The prognostic nutritional index is a score that represents a patient's immune-nutritional status based on the lymphocyte count and serum albumin concentration. We hypothesized that preoperative prognostic nutritional index is associated with postoperative complications and long-term outcomes after curative resection of lung cancer.We retrospectively analyzed 1011 patients with pathologic stage I-III adenocarcinoma and squamous cell carcinoma who underwent open thoracotomy for curative resection of lung cancer. The preoperative prognostic nutritional index was calculated as follows based on preoperative laboratory data: 10 × serum albumin (g/dL) + 5 × total lymphocyte count (/nL). The cutoff value of prognostic nutritional index (cutoff value: 50) was obtained by receiver operating characteristics curve and patients were classified as high and low groups. Outcomes were compared with the use of propensity scores and inverse probability weighting adjustment to reduce treatment selection bias.The low group exhibited more postoperative complications (34% [96/285] vs 24% [174/726]; P = .002) especially pneumonia (13% [36/285] vs 6% [41/756]; P .001) and delirium (10% [29/285] vs 5% [36/726]; P = .002), and greater in-hospital mortality (4% [11/285] vs 1% [9/726]; P = .007) than the high group. A low prognostic nutritional index was associated with greater postoperative pulmonary complications [odds ratio, 1.7; 95% confidence interval, 1.3-2.3], lower recurrence-free survival (hazard ratio, 1.3; 95% confidence interval, 1.1-1.5), and overall survival (hazard ratio, 1.5; 95% confidence interval, 1.2-1.8) after balancing the covariables.The preoperative prognostic nutritional index was associated with postoperative pulmonary complications and long-term outcomes after curative resection of non-small cell lung cancer.
- Published
- 2020
32. Intraoperative use of dexmedetomidine for the prevention of emergence agitation and postoperative delirium in thoracic surgery: a randomized-controlled trial
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Hyun Joo Ahn, Mikyung Yang, Sang Hyun Lee, Jie Ae Kim, Heejoon Jeong, and Bong Gyu Seong
- Subjects
Male ,medicine.medical_specialty ,Sevoflurane ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Emergence Delirium ,Randomized controlled trial ,Double-Blind Method ,030202 anesthesiology ,law ,Anesthesiology ,medicine ,Clinical endpoint ,Humans ,Hypnotics and Sedatives ,030212 general & internal medicine ,Prospective Studies ,Dexmedetomidine ,Lung ,Aged ,Intraoperative Care ,business.industry ,Thoracoscopy ,General Medicine ,Middle Aged ,Anesthesiology and Pain Medicine ,Cardiothoracic surgery ,Anesthesia ,Relative risk ,Anesthetics, Inhalation ,Delirium ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
We investigated whether preventive use of dexmedetomidine during surgery was effective for reducing emergence agitation and postoperative delirium.In this double-blind randomized-controlled trial, 143 patients undergoing thoracoscopic lung resection surgery were randomly assigned to the dexmedetomidine-sevoflurane (DEX-Sevo, n = 73) or sevoflurane (Sevo, n = 70) groups. Dexmedetomidine or saline administration was started after inducing anesthesia and continued until the end of surgery at a fixed dose (0.5 µg·kgThe DEX-Sevo group showed less frequent emergence agitation than the Sevo group (13% vs 35%, respectively; relative risk, 0.38; 95% confidence interval [CI], 0.18 to 0.79; P = 0.011) but the incidence of delirium after discharge from the postanesthesia care unit was not different (25% vs 25%, DEX-Sevo vs Sevo). Both pro- and anti-inflammatory cytokines were lower in the DEX-Sevo group than in the Sevo group. Nevertheless, the interleukin (IL)6/IL10 ratio (median difference, 5.8; 95% CI,1.8 to 10.0; P = 0.012) and IL8/IL10 ratio (median difference, 0.8; 95% CI, 0.2 to 1.3; P = 0.007) were higher in the DEX-Sevo group than in the Sevo group, indicating a pro-inflammatory cytokine balance in the DEX-Sevo group. Norepinephrine and epinephrine levels were lower in the DEX-Sevo group than in the Sevo group (both, P0.001).Intraoperative dexmedetomidine reduced emergence agitation but not postoperative delirium in patients undergoing thoracic surgery. Dexmedetomidine seemed to affect emergence agitation through catecholamines, but not through an anti-inflammatory action. Trial registration Clinical Research Information Service (KCT 0001877); registered 7 April, 2016.RéSUMé: OBJECTIF: Nous avons cherché à savoir si l’utilisation préventive de dexmédétomidine au cours de la chirurgie pouvait réduire la survenue de l’agitation au réveil et du delirium postopératoire. MéTHODES: Dans cette étude randomisée, contrôlée à double insu, 143 patients subissant une résection pulmonaire par thoracoscopie ont été randomisés dans un groupe recevant dexmédétomidine-sévoflurane (DEX-Sévo, n = 73) ou dans un groupe recevant seulement du sévoflurane (Sévo, n = 70). L’administration de dexmédétomidine ou de solution saline a débuté après l’induction de l’anesthésie et a continué jusqu’à la fin de l’intervention à une dose fixe de 0,5 µg·kg
- Published
- 2018
33. Non-intubated video-assisted thoracoscopic lung biopsy for interstitial lung disease: a single-center experience
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Sangmin M. Lee, Dong Woog Yoon, Hyun Joo Ahn, Mikyung Yang, Seong Mi Moon, Jie Ae Kim, Jong Ho Cho, Chang-Seok Jeon, and Sumin Shin
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,Interstitial lung disease ,Retrospective cohort study ,Lung biopsy ,respiratory system ,030204 cardiovascular system & hematology ,medicine.disease ,Single Center ,respiratory tract diseases ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Thoracoscopic lung biopsy ,medicine ,Intubation ,Original Article ,Video assisted ,business - Abstract
Background: The mortality and morbidity associated with video-assisted thoracoscopic (VATS) lung biopsy for interstitial lung disease (ILD) are not negligible. We evaluated whether non-intubated VATS lung biopsy, which avoids intubation and general anesthesia, can be safely performed in ILD subjects. Methods: This retrospective study compared the incidence of complications and surgical mortality between 25 consecutive intubated subjects and 10 non-intubated subjects (a total of 35 consecutive subjects) at a single institution. Results: No major surgical complications or deaths were reported in either group, and non-intubated VATS biopsies were safely performed in subjects with relatively low carbon monoxide diffusing capacity (P=0.08) or poor American Society of Anesthesiologists physical status scores (ASA) (P=0.02). Conclusions: These preliminary results suggest that non-intubated VATS lung biopsy is a safe and feasible option in patients with ILD.
- Published
- 2018
34. Role of reactive oxygen species at reperfusion stage in isoflurane preconditioning-induced neuroprotection
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Jeong Jin Lee, Gunn Hee Kim, Hyun Sung Cho, Jie Ae Kim, and Sang Hyun Lee
- Subjects
Male ,0301 basic medicine ,Cell Survival ,Cell ,Caspase 3 ,Pharmacology ,PC12 Cells ,Neuroprotection ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,medicine ,Animals ,Viability assay ,Molecular Biology ,chemistry.chemical_classification ,Reactive oxygen species ,TUNEL assay ,Isoflurane ,General Neuroscience ,Infarction, Middle Cerebral Artery ,Rats ,Neuroprotective Agents ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Reperfusion Injury ,Anesthetics, Inhalation ,Reperfusion ,Neurology (clinical) ,Reactive Oxygen Species ,030217 neurology & neurosurgery ,Signal Transduction ,Developmental Biology ,medicine.drug - Abstract
In this in vivo and in vitro study, we aimed to investigate whether isoflurane preconditioning-induced neuronal protection is mediated by reactive oxygen species (ROS) signaling at the reperfusion stage. In the in vivo study, Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) and in the in vitro study, rat pheochromocytoma (PC12) cells were subjected to oxygen glucose deprivation (OGD). Isoflurane preconditioning was carried out prior to MCAO or OGD and the ROS scavenger, N-2-mercaptopropiopylglycine (2-MPG), was administered at the start of reperfusion. Infarct volume, neurological severity score, and TUNEL staining were analyzed in the in vivo study and cell viability, Bcl-2/Bax ratio, cleaved caspase 3/caspase 3 ratio, and ROS fluorescence intensity were measured in the in vitro study. In the in vivo study, infarct volume, neurological severity score, and TUNEL-positive cell count were significantly decreased with preconditioning but were abrogated by administration of 2-MPG. In the in vitro study, cell viability and Bcl-2/Bax ratio were significantly increased with preconditioning, and cleaved caspase-3/caspase-3 ratio and ROS fluorescence intensity were significantly decreased. Administration of 2-MPG for 10 min abrogated this preconditioning effect, but it did not abolish the protection when administered for 60 min of reperfusion. Isoflurane preconditioning-induced protection was abolished by ROS scavengers at the start of reperfusion, indicating that ROS signaling can mediate the isoflurane preconditioning effect, which suggests that the time window can be important.
- Published
- 2019
35. Stroke Volume Variation and Pulse Pressure Variation Are Not Useful for Predicting Fluid Responsiveness in Thoracic Surgery
- Author
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Hyo Won Park, Mikyung Yang, Joo Hyun Park, Jie Ae Kim, Hyun Joo Ahn, and Dae Myoung Jeong
- Subjects
Male ,medicine.medical_specialty ,Fluid responsiveness ,Blood Pressure ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,Predictive Value of Tests ,Medicine ,Humans ,Prospective Studies ,Aged ,business.industry ,Thoracic cavity ,Thoracic Surgery, Video-Assisted ,030208 emergency & critical care medicine ,Stroke Volume ,Stroke volume ,Middle Aged ,Thoracic Surgical Procedures ,Pulse pressure ,Preload ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Cardiothoracic surgery ,Elective Surgical Procedures ,Anesthesia ,Breathing ,Fluid Therapy ,Female ,business - Abstract
Stroke volume variation (SVV) and pulse pressure variation (PPV) are used as indicators of fluid responsiveness, but little is known about the usefulness of these dynamic preload indicators in thoracic surgery, which involves an open thoracic cavity and 1-lung ventilation (OLV). Therefore, we investigated whether SVV and PPV could predict fluid responsiveness, and whether the thresholds of these parameters should be adjusted for thoracic surgery.This was a prospective, controlled study conducted in a tertiary care center. Eighty patients scheduled for an elective lobectomy requiring OLV were included (n = 40, video-assisted thoracoscopic surgery (VATS); n = 40, open thoracotomy). Twenty minutes after opening the thoracic cavity, 7 mL/kg hydroxyethyl starch was administered for 30 minutes. Various hemodynamic parameters were measured before and after fluid challenge.Among the 80 patients enrolled in this study, 37% were fluid responders (increase in stroke volume index ≥10%). SVV before fluid challenge was not different between nonresponders and responders (mean ± SD: 7.1 ± 2.7% vs 7.4 ± 2.6%, P = .68). This finding was true regardless of whether the surgery involved open thoracotomy or VATS. PPV before fluid challenge showed the difference between nonresponders and responders (mean ± SD: 6.9 ± 3.0% vs 8.4 ± 3.2%; P = .045); however, the sensitivity and specificity of the threshold value (PPV = 7%) were low (58% and 62%, respectively) and the area under the receiver operating characteristics curve was only 0.63 (95% confidence interval, 0.52-0.74; P = .041).Dynamic preload indicators are not useful for predicting fluid responsiveness in VATS or open thoracic surgery.
- Published
- 2017
36. Respiratory insufficiency and dynamic hyperinflation after rigid bronchoscopy in a patient with relapsing polychondritis -a case report
- Author
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Mikyung Yang, Jie Ae Kim, Eun Kyung Lee, and Hyun-Joo Ahn
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Subglottic stenosis ,Relapsing polychondritis ,Case Report ,lcsh:RD78.3-87.3 ,Bronchoscopy ,Hyperventilation ,medicine ,Dynamic hyperinflation ,Mechanical ventilation ,Tracheobronchomalacia ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Surgery ,Anesthesiology and Pain Medicine ,lcsh:Anesthesiology ,Breathing ,Acquired subglottic stenosis ,medicine.symptom ,business ,Respiratory insufficiency - Abstract
Relapsing polychondritis (RP) is an uncommon disease that is characterized by inflammation and destruction of carti laginous structures. When tracheobronchial tree is involved, respiratory obstructive symptoms can occur. A 35-year-old man, with a previous diagnosis of RP, was scheduled for rigid bronchoscopy to relieve dyspnea, caused by subglottic stenosis. After laser splitting of the subglottic web, the spontaneous respiration of the patient was insufficient, and hypercar bia developed progressively even with assisted ventilation. After 20 minutes of aggressive hyperventilation to reduce endtidal CO2 level, sudden extreme tachycardia and hypotension developed. Ventilation rate was reduced and prolonged expiration time was allowed to alleviate a near-tampon status from dynamic hyperinflation. After the hemodynamic status was stabilized, the patient was transferred to the ICU for mechanical ventilation. He received ICU care for 30 days, and now, he was on supportive care on a ward, considering Y stent insertion to prevent luminal collapse from tracheobronchomalacia. (Korean J Anesthesiol 2013; 65: 569-573)
- Published
- 2013
37. Blocking the double-lumen orifice versus apneic oxygenation during 1-lung ventilation
- Author
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Dae Myung Jung, Suyong Jeon, Su Min Shin, Hyun Joo Ahn, Mikyung Yang, Jie Ae Kim, and Sin Ho Jung
- Subjects
Pulmonary and Respiratory Medicine ,Insufflation ,medicine.medical_specialty ,Lumen (anatomy) ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Hypoxia ,Lung ventilation ,Apneic oxygenation ,business.industry ,Blocking (radio) ,Incidence ,Respiration, Artificial ,One lung ventilation ,One-Lung Ventilation ,Oxygen ,030228 respiratory system ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Body orifice - Published
- 2017
38. A combined variation of the right urogenital veins and bilaterally renal arteries
- Author
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Jie Ae Kim, Sang-Pil Yoon, and E. H. Park
- Subjects
Histology ,Right renal vein ,Genitourinary system ,business.industry ,Right testicular vein ,Anatomy ,urologic and male genital diseases ,Renal hilum ,Subcardinal Vein ,medicine.anatomical_structure ,Cadaver ,medicine.artery ,medicine ,Renal artery ,business ,Cause of death - Abstract
Variation in urogenital vessels is of interest to clinicians as well as anatomists since it has complex steps of urogenital development. We found 2 right and 3 left renal arteries, double right renal veins, the right testicular artery arisen from the right main renal artery, and the right testicular vein as a tributary of an additional right renal vein in a 57-year-old Korean male cadaver, whose cause of death was 'unknown'. The multiple vascular variations near the renal hilum are detectable in seemingly normal individuals and a deeper understanding of the complicated urogenital vasculature might be very important with its embryogenesis.
- Published
- 2015
39. Reactive Oxygen Species by Isoflurane Mediates Inhibition of Nuclear Factor κB Activation in Lipopolysaccharide-Induced Acute Inflammation of the Lung
- Author
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Hyun Sung Choi, Mikyung Yang, Ju A. Kim, Sang Min Lee, In Sun Chung, Jeong Jin Lee, Hyun Joo Ahn, and Jie Ae Kim
- Subjects
Lipopolysaccharides ,Male ,Lipopolysaccharide ,Acute Lung Injury ,Blotting, Western ,Fluorescent Antibody Technique ,Nitric Oxide Synthase Type II ,Inflammation ,Pharmacology ,Lung injury ,Real-Time Polymerase Chain Reaction ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Cytosol ,medicine ,Animals ,Cell Nucleus ,chemistry.chemical_classification ,Reactive oxygen species ,Isoflurane ,biology ,medicine.diagnostic_test ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,NF-kappa B ,Pneumonia ,Rats ,Nitric oxide synthase ,Phenotype ,Anesthesiology and Pain Medicine ,Bronchoalveolar lavage ,Neutrophil Infiltration ,chemistry ,Anesthesia ,Anesthetics, Inhalation ,biology.protein ,Cytokines ,Tumor necrosis factor alpha ,medicine.symptom ,Reactive Oxygen Species ,business ,Bronchoalveolar Lavage Fluid ,medicine.drug - Abstract
BACKGROUND: Although anesthetic-induced inhibition of lipopolysaccharide (LPS)-induced lung injury has been recognized, the underlying mechanism is obscure. Some studies suggest that reactive oxygen species (ROS) by isoflurane play a crucial role for anesthetic-induced protective effects on the brain or the heart; however, it still remains controversial. In this study, we examined the role of isoflurane-derived ROS in isoflurane-induced inhibition of lung injury and nuclear factor κB (NFκB) activation in LPS-challenged rat lungs. METHODS: Male Sprague-Dawley rats were subjected to inhalation of 1.0 minimum alveolar concentration of isoflurane for 60 minutes, and intratracheal LPS 0.1 mg was administered 60 minutes later. In some cases, ROS scavenger, 2-mercaptopropinyl glycine or N-acetylcysteine was given 30 minutes before isoflurane. ROS generation was measured by fluorometer before LPS challenge and 4 hours after. Isoflurane’s preconditioning effect was assessed by histologic examination, protein content, neutrophil recruitment, and determination of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 levels in bronchoalveolar lavage fluid and lung tissue. Western blotting measured phosphorylation of inhibitory κB α (ser 32/36), NFκB p65, and inducible nitric oxide synthase (iNOS). TNF-α and IL-6 mRNA expression and immunofluorescence staining for iNOS were also assessed. RESULTS: Isoflurane preconditioning reduced inflammatory lung injury and TNF-α, IL-1β, and IL-6 release in the lung. Isoflurane upregulated ROS generation before LPS but inhibited a ROS burst after LPS challenge. ROS scavenger administration before isoflurane abolished the isoflurane preconditioning effect as well as isoflurane-induced inhibition of phosphorylation of inhibitory κBα, NFκB p65, iNOS activation, and mRNA expression of TNF-α and IL-6 in acute LPS-challenged lungs. CONCLUSIONS: This study suggests a crucial role of upregulated ROS generation by isoflurane for modification of inflammatory pathways by isoflurane preconditioning in acute inflammation of the lung.
- Published
- 2013
40. Risk score for postoperative complications in thoracic surgery
- Author
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Jie-Ae Kim, Mikyung Yang, Jae Myung Yu, and Hyun Joo Ahn
- Subjects
medicine.medical_specialty ,Clinical Research Article ,Framingham Risk Score ,Lung ,business.industry ,medicine.medical_treatment ,Esophageal cancer ,Lung injury ,medicine.disease ,Surgery ,lcsh:RD78.3-87.3 ,Pneumonectomy ,Postoperative complications ,Thoracic surgery ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Cardiothoracic surgery ,lcsh:Anesthesiology ,Anesthesia ,Risk scores ,Medicine ,In patient ,Completion Pneumonectomy ,business - Abstract
Background: Risk scoring system for thoracic surgery patients have not been widely used, as of recently. We tried to forge a risk scoring system that predicts the risk of postoperative complications in patients undergoing major thoracic surgery. We used a prolonged ICU stay as a representative of postoperative complications and tested various possible risk factors for its relation. Methods: Data from all patients who underwent major lung and esophageal cancer surgeries, between 2005 and 2007 in our hospital, were collected retrospectively (n = 858). Multiple logistic regression analysis was performed with various possible risk factors to build the risk scoring system for prolonged ICU stay (> 3 days). Results: A total of 9% of patients exhibited more than 3 days of ICU stay. Age, operation name, preoperative lung injury, no epidural analgesia, and predicted post operative forced expiratory volume in 1 second (ppoFEV1) were the risk factors for prolonged ICU stay, by multivariable analysis (P < 0.05). Risk score, p was derived from the formula: logit(p/[1-p]) = -5.39 + 0.06 × age + 1.12 × operation name(2) + 1.52 × operation name(3) + 1.32 × operation name(4) + 1.56 × operation name(5) + 1.30 × preoperative lung injury + 0.72 × no epidural analgesia - 0.02 × ppoFEV1 [Age in years, operation name(2): pneumonectomy, operation name(3): esophageal cancer operation, operation name(4): completion pneumonectomy, operation name(5): extended operation, preoperative lung injury(+), epidural analgesia(-), ppoFEV1 in %]. Conclusions: Age, operation name, preoperative lung injury, epidural analgesia, and ppoFEV1 can predict postoperative morbidity in thoracic surgery patients. (Korean J Anesthesiol 2012; 63: 527-532)
- Published
- 2012
41. Influence of carbon dioxide insufflation of the neck on intraocular pressure during robot-assisted endoscopic thyroidectomy: a comparison with open thyroidectomy
- Author
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Yeon-Kyeong Yoo, Jee-Soo Kim, Duk-Kyung Kim, Jie-Ae Kim, and Moon-Seok Chang
- Subjects
Male ,Intraocular pressure ,genetic structures ,medicine.medical_treatment ,Thyroid Nodule ,Anesthetics, Local ,Carbon dioxide insufflation ,medicine.diagnostic_test ,Robotics ,Middle Aged ,Anesthesia ,Anesthetics, Inhalation ,Thyroidectomy ,Female ,Drug Antagonism ,medicine.drug ,Adult ,Methyl Ethers ,Insufflation ,medicine.medical_specialty ,Tetracaine ,Patient Positioning ,Sevoflurane ,Tonometry, Ocular ,Monitoring, Intraoperative ,Intubation, Intratracheal ,Pressure ,medicine ,Humans ,Thyroid Neoplasms ,Intraocular Pressure ,business.industry ,Endoscopy ,Carbon Dioxide ,Overweight ,Carcinoma, Papillary ,eye diseases ,Surgery ,Endoscopic thyroidectomy ,Stress, Mechanical ,sense organs ,Jugular Veins ,business ,Neck ,Abdominal surgery - Abstract
Increased intraocular pressure (IOP) during surgery can result in serious ophthalmic complications. We hypothesized that carbon dioxide (CO₂) insufflation of the neck during endoscopic thyroidectomy would constrict the jugular veins mechanically, causing elevated venous pressure and thus elevated IOP. We compared IOP changes at each step of open thyroidectomy (OT) versus robot-assisted endoscopic thyroidectomy (RET) METHODS: Perioperatively, IOP was measured at six time points in patients undergoing OT (n = 18) or RET with CO₂ insufflation (n = 19). Anesthesia, ventilatory strategy, intravenous infusions, and surgical positioning were standardizedIn both groups, induction of anesthesia reduced IOP, but surgical positioning with the neck in extension had no effect on IOP. In the OT group, IOP remained unchanged during anesthesia. In the RET group, CO₂ insufflation significantly increased IOP to an average of 3.6 ± 3.0 mmHg higher than the previous measurement (P0.001), and this IOP increase persisted immediately before gas deflation. These elevated IOP values during CO₂ insufflation in the RET group were significantly higher than those at corresponding time points in the OT group. However, these elevated IOP values were similar to the pre-anesthetic baseline IOP CONCLUSION: CO₂ insufflation of the neck at pressure of 6 mmHg increased the IOP significantly compared with open thyroidectomy. However, this increase in IOP could be balanced by an anesthetic-induced IOP-lowering effect, thereby having no clinical significance in patients with normal IOP undergoing robot-assisted endoscopic thyroidectomy.
- Published
- 2012
42. Comparison Between Phenylephrine and Dopamine in Maintaining Cerebral Oxygen Saturation in Thoracic Surgery: A Randomized Controlled Trial
- Author
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Mikyung Yang, Sangmin M. Lee, Hyun Joo Ahn, Jie Ae Kim, Ji Won Choi, and Jin Hee Ahn
- Subjects
Male ,Mean arterial pressure ,Cardiac output ,Dopamine ,Remifentanil ,Hemodynamics ,Hemoglobins ,Phenylephrine ,Double-Blind Method ,medicine ,Humans ,Cardiac Output ,Sympathomimetics ,Infusions, Intravenous ,Pneumonectomy ,Aged ,business.industry ,Age Factors ,Clinical Trial/Experimental Study ,General Medicine ,Oxygenation ,One-Lung Ventilation ,Oxygen ,Blood pressure ,Anesthesia ,Bispectral index ,Cerebrovascular Circulation ,Female ,business ,Research Article ,medicine.drug - Abstract
Fluid is usually restricted during thoracic surgery, and vasoactive agents are often administered to maintain blood pressure. One-lung ventilation (OLV) decreases arterial oxygenation; thus oxygen delivery to the brain can be decreased. In this study, we compared phenylephrine and dopamine with respect to maintaining cerebral oxygenation during OLV in major thoracic surgery. Sixty-three patients undergoing lobectomies were randomly assigned to the dopamine (D) or phenylephrine (P) group. The patients’ mean arterial pressure was maintained within 20% of baseline by a continuous infusion of dopamine or phenylephrine. Maintenance fluid was kept at 5 mL/kg/h. The depth of anesthesia was maintained with desflurane 1MAC and remifentanil infusion under bispectral index guidance. Regional cerebral oxygen saturation (rScO2) and hemodynamic variables were recorded using near-infrared spectroscopy and esophageal cardiac Doppler. The rScO2 was higher in the D group than the P group during OLV (OLV 60 min: 71 ± 6% vs 63 ± 12%; P = 0.03). The number of patients whose rScO2 dropped more than 20% from baseline was 0 and 6 in the D and P groups, respectively (P = 0.02). The D group showed higher cardiac output, but lower mean arterial pressure than the P group (4.7 ± 1.0 vs 3.9 ± 1.2 L/min; 76.7 ± 8.1 vs 84.5 ± 7.5 mm Hg; P = 0.02, P = 0.02). Among the variables, age, hemoglobin concentration, and cardiac output were associated with rScO2 by correlation analysis. Dopamine was superior to phenylephrine in maintaining cerebral oxygenation during OLV in thoracic surgery.
- Published
- 2015
43. Does a Protective Ventilation Strategy Reduce the Risk of Pulmonary Complications After Lung Cancer Surgery?
- Author
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Hyo Jin Kim, Jie Ae Kim, Myung Joo Kim, Chin A Yi, Kwhanmien Kim, Hyun Joo Ahn, and Mikyung Yang
- Subjects
Pulmonary and Respiratory Medicine ,ARDS ,Lung cancer surgery ,medicine.medical_specialty ,business.industry ,Environmental air flow ,Peak inspiratory pressure ,Lung injury ,Critical Care and Intensive Care Medicine ,medicine.disease ,Surgery ,Anesthesia ,Breathing ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Tidal volume ,Positive end-expiratory pressure - Abstract
Background Protective ventilation strategy has been shown to reduce ventilator-induced lung injury in patients with ARDS. In this study, we questioned whether protective ventilatory settings would attenuate lung impairment during one-lung ventilation (OLV) compared with conventional ventilation in patients undergoing lung resection surgery. Methods One hundred patients with American Society of Anesthesiology physical status 1 to 2 who were scheduled for an elective lobectomy were enrolled in the study. During OLV, two different ventilation strategies were compared. The conventional strategy (CV group, n = 50) consisted of F io 2 1.0, tidal volume (V t ) 10 mL/kg, zero end-expiratory pressure, and volume-controlled ventilation, whereas the protective strategy (PV group, n = 50) consisted of F io 2 0.5, V t 6 mL/kg, positive end-expiratory pressure 5 cm H2O, and pressure-controlled ventilation. The composite primary end point included Pa o 2/F io 2 o 2), Pa co 2, and peak inspiratory pressure (PIP) were repeatedly measured. Results During OLV, although 58% of the PV group needed elevated F io 2 to maintain an Sp o 2 > 95%, PIP was significantly lower than in the CV group, whereas the mean Pa co 2 values remained at 35 to 40 mm Hg in both groups. Importantly, in the PV group, the incidence of the primary end point of pulmonary dysfunction was significantly lower than in the CV group (incidence of Pa o 2/F io 2 Conclusion Compared with the traditional large V t and volume-controlled ventilation, the application of small V t and PEEP through pressure-controlled ventilation was associated with a lower incidence of postoperative lung dysfunction and satisfactory gas exchange. Trial registry Australian New Zealand Clinical Trials Registry; No.: ACTRN12609000861257; URL: www.anzctr.org.au
- Published
- 2011
44. Improvement of sleep-related breathing disorder in patients with end-stage renal disease after kidney transplantation
- Author
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Jie Ae Kim, Gaab Soo Kim, Gunn Hee Kim, Sung Joo Kim, Jin Gu Kang, Hae Hyuk Jung, and Jeong Jin Lee
- Subjects
Transplantation ,medicine.medical_specialty ,business.industry ,Disease ,medicine.disease ,End stage renal disease ,Surgery ,Internal medicine ,Cardiology ,Breathing ,Medicine ,In patient ,Sleep study ,business ,Kidney transplantation - Abstract
Lee JJ, Kim GS, Kim JA, Kim S-J, Kang JG, Kim GH, Jung HH. Improvement of sleep-related breathing disorder in patients with end-stage renal disease after kidney transplantation. Clin Transplant 2011: 25: 126–130. © 2009 John Wiley & Sons A/S. Abstract: Sleep-related breathing disorder (SRBD) is a common symptom of end-stage renal disease (ESRD). The aim of this study was to determine whether kidney transplantation improves SRBD. Twenty-four patients with ESRD, who were admitted for kidney transplantation, underwent a sleep study using a portable ventilation effort recorder on the night before transplantation. Of these patients, 20 could repeat the overnight monitoring two wk after the transplantation. The median apnea-hypopnea index (AHI) of the 20 patients was 13.5 (range, 2–40), and significantly reduced to 4.5 (range, 0–20) after transplantation (p = 0.003). This reduction was most prominent in 12 patients with SRBD, for whom the median AHI fell from 22 (range, 10–40) to 6.5 (range, 1–20; p = 0.010). SRBD improvement, defined as an AHI equal to or >50% and/or reduced to
- Published
- 2011
45. Comparison of the effectiveness of lidocaine and salbutamol on coughing provoked by intravenous remifentanil during anesthesia induction
- Author
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Jin-Kyoung Kim, Jie Ae Kim, Mikyung Yang, Gunn Hee Kim, Hyun Joo Ahn, Hyo Jin Kim, Sira Bang, and Hyun-Sung Cho
- Subjects
medicine.medical_specialty ,Clinical Research Article ,Side effect ,Lidocaine ,business.industry ,Incidence (epidemiology) ,Remifentanil ,Salbutamol ,Odds ratio ,Surgery ,respiratory tract diseases ,lcsh:RD78.3-87.3 ,Anesthesiology and Pain Medicine ,Cough ,lcsh:Anesthesiology ,Anesthesiology ,Anesthesia ,Medicine ,Anesthesia induction ,business ,medicine.drug - Abstract
Background: Coughing is a side effect of opioids that is rarely studied. Here, we evaluated the incidence of remifentanil induced coughing during anesthesia induction in an attempt to identify its risk factors and to examine the preventive effects of lidocaine and salbutamol. Methods: A total of 237 patients scheduled to undergo general anesthesia were allocated randomly into three groups. Group C received no medication, while Group L received 2% lidocaine at 0.5 mg/kg intravenously 1 minute prior to remifentanil infusion and Group S inhaled one metered aerosol puff of salbutamol 15 minutes prior to entering the operating room. Remifentanil was infused at 5 ng/ml by target controlled infusion and coughing was measured for five minutes and graded as none, mild, moderate, or severe based on the number of coughs. Results: The incidences of coughing were 30.4%, 25.3%, and 35.4% in Groups C, L, and S, respectively. The incidences, onset times, and severity of coughing did not differ significantly among groups. In addition, multivariate analysis showed that non-smoking and a lower body weight were risk factors of remifentanil-induced coughing (odds ratio, 8.13; P = 0.024, 1.11, and 0.004, respectively). Conclusions: The incidence of remifentanil-induced coughing was 30%. A total of 0.5 mg/kg lidocaine and 1 metered aerosol puff of salbutamol did not prevent coughing. Non-smoking and low body weight were found to be risk factors of remifentanil-induced coughing. (Korean J Anesthesiol 2010; 59: 319-322)
- Published
- 2010
46. Intrathecal morphine combined with intravenous patient-controlled analgesia is an effective and safe method for immediate postoperative pain control in live liver donors
- Author
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Tae Soo Hahm, Hyun Sung Cho, Soo Joo Choi, Mi Sook Gwak, Jae-Won Joh, Kyoung Mi Kim, Hyun Joo Ahn, Jie Ae Kim, Gaab Soo Kim, and Justin Sangwook Ko
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Meperidine ,Visual analogue scale ,Nausea ,Sedation ,medicine.medical_treatment ,Liver transplantation ,Drug Administration Schedule ,Fentanyl ,law.invention ,Young Adult ,Randomized controlled trial ,law ,Living Donors ,medicine ,Hepatectomy ,Humans ,Prospective Studies ,Infusions, Intravenous ,Injections, Spinal ,Pain Measurement ,Pain, Postoperative ,Transplantation ,Morphine ,Hepatology ,business.industry ,Analgesia, Patient-Controlled ,Liver Transplantation ,Surgery ,Analgesics, Opioid ,Treatment Outcome ,Anesthesia ,Vomiting ,Drug Therapy, Combination ,Female ,medicine.symptom ,business ,medicine.drug ,Intravenous Patient-Controlled Analgesia - Abstract
The healthy condition of living donors makes their tolerance to pain particularly low, and clinicians are often challenged to come up with an analgesic technique that is effective yet ensures donor safety. This study compared, in donor right hepatectomy, the efficacy and safety of preoperative intrathecal morphine (ITM) combined with intravenous patient-controlled analgesia (IV-PCA) with IV-PCA alone. Forty adult patients were randomly allocated into 2 groups: ITM+IV-PCA group (n = 20) and IV-PCA-only group (n = 20). Patients in the ITM+IV-PCA group received morphine sulfate (400 microg). The visual analog scale (VAS) at rest and when coughing and supplementary meperidine and IV-PCA (fentanyl) consumption were assessed at 2, 4, 6, 8, 10, 12, 18, 24, 30, 36, 42, 48 56, 64, and 72 hours after surgery. Also, side effects such as sedation, dizziness, nausea, vomiting, pruritus, and respiratory depression were evaluated. The ITM+IV-PCA group showed significantly less pain at rest and when coughing for up to 30 hours and 24 hours, respectively. Cumulative postoperative consumption of meperidine and IV-PCA (fentanyl) were significantly less in the ITM+IV-PCA group. The incidence of side effects were comparable between the 2 groups except for pruritus; its incidence was significantly higher in the ITM+IV-PCA group during the first 24 hours, but no treatment was required due to its mild severity. The results of our study suggest that preoperative ITM combined with IV-PCA may be considered as an effective and safe pain management regimen in living liver donors who have characteristics of low tolerance to pain and postoperative coagulation derangement.
- Published
- 2009
47. Protective Effects of Gabapentin on Allodynia and α2δ1-Subunit of Voltage-dependent Calcium Channel in Spinal Nerve-Ligated Rats
- Author
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Sangmin M. Lee, Hyun Joo Ahn, Mi Sook Gwak, Seung Woon Lim, Soo Joo Choi, Jie Ae Kim, Hyun Sung Cho, Han-Seop Kim, Tae Soo Hahm, Woo Seog Sim, and Chang-Dae Bae
- Subjects
Male ,Gabapentin ,Calcium Channels, L-Type ,Cyclohexanecarboxylic Acids ,Alpha 2 Delta-1 Subunit ,Rats, Sprague-Dawley ,medicine ,Animals ,Amines ,Ligation ,gamma-Aminobutyric Acid ,Neuropathic Pain ,Pain Measurement ,Analgesics ,Voltage-dependent calcium channel ,business.industry ,Calcium channel ,General Medicine ,medicine.disease ,Rats ,Up-Regulation ,Disease Models, Animal ,Protein Subunits ,Allodynia ,Protective ,Spinal Nerves ,Spinal nerve ,Anesthesia ,Neuropathic pain ,Neuralgia ,Original Article ,Calcium Channels ,medicine.symptom ,business ,Injections, Intraperitoneal ,medicine.drug - Abstract
This study was designed to determine whether early gabapentin treatment has a protective analgesic effect on neuropathic pain and compared its effect to the late treatment in a rat neuropathic model, and as the potential mechanism of protective action, the alpha(2)delta(1)-subunit of the voltage-dependent calcium channel (alpha(2)delta(1)-subunit) was evaluated in both sides of the L5 dorsal root ganglia (DRG). Neuropathic pain was induced in male Sprague-Dawley rats by a surgical ligation of left L5 nerve. For the early treatment group, rats were injected with gabapentin (100 mg/kg) intraperitoneally 15 min prior to surgery and then every 24 hr during postoperative day (POD) 1-4. For the late treatment group, the same dose of gabapentin was injected every 24 hr during POD 8-12. For the control group, L5 nerve was ligated but no gabapentin was administered. In the early treatment group, the development of allodynia was delayed up to POD 10, whereas allodynia was developed on POD 2 in the control and the late treatment group (p0.05). The alpha(2)delta(1)-subunit was up-regulated in all groups, however, there was no difference in the level of the alpha(2)delta(1)-subunit among the three groups. These results suggest that early treatment with gabapentin offers some protection against neuropathic pain but it is unlikely that this action is mediated through modulation of the alpha(2)delta(1)-subunit in DRG.
- Published
- 2009
48. Risk Factors for Post-pneumonectomy Acute Lung Injury/Acute Respiratory Distress Syndrome in Primary Lung Cancer Patients
- Author
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J W Yoon, Y M Shim, Jie Ae Kim, Kwhanmien Kim, Mina Yang, Gee Yiung Suh, K Jeon, H Kim, and O J Kwon
- Subjects
Male ,ARDS ,Lung Neoplasms ,medicine.medical_treatment ,Acute Lung Injury ,Lung injury ,Critical Care and Intensive Care Medicine ,Pneumonectomy ,Interquartile range ,Tidal Volume ,medicine ,Humans ,Hospital Mortality ,Carcinoma, Small Cell ,Lung cancer ,Tidal volume ,Aged ,Mechanical ventilation ,Respiratory Distress Syndrome ,business.industry ,Airway Resistance ,Length of Stay ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Anesthesia ,Breathing ,Female ,Epidemiologic Methods ,business - Abstract
Acute lung injury/acute respiratory distress syndrome (ALI / ARDS) is the most serious pulmonary complication after lung resection. This study investigated the incidence and outcome of patients with ALI / ARDS who required mechanical ventilation within one week of undergoing pneumonectomy for primary lung cancer and analysed the risk factors. We retrospectively reviewed the medical records of 146 patients who underwent pneumonectomy for primary lung cancer between May 2001 and April 2006. Preoperative, perioperative and postoperative clinical data were analysed. Post-pneumonectomy ALI / ARDS developed within the first postoperative week in 18 (12%) patients. Patients who developed ALI / ARDS had a longer hospital duration of stay (median [interquartile range], 26 [18 to 75] vs. 8 [7 to 11] days; P < 0.001) and higher in-hospital mortality (12 [67%] vs. 0 [0%]; P < 0.001). In an univariate analysis, post-pneumonectomy ALI / ARDS was associated with larger tidal volume (V(T)) and higher airway pressure (P(aw)) during one-lung ventilation (V(T) 8.2 [7.5 to 9.0] vs. 7.7 [6.9 to 8.2] ml/kg predicted body weight, P = 0.016; P(aw), 28.9 [27.6 to 30.0] vs. 27.2 [25.6 to 28.5] cmH2O, P = 0.001). V(T) during two-lung ventilation was also greater in patients who developed ALI / ARDS (P = 0.014) than in those who did not, but P(aw) during two-lung ventilation did not differ (P = 0.950). In a multiple logistic regression analysis, post-pneumonectomy ALI / ARDS was independently associated with a larger V(T) (OR 3.37 per 1 ml/kg predicted body weight increase; 95% confidence interval 1.65 to 6.86) and higher P(aw) (OR 2.32 per 1 cmH2O increase; 95% confidence interval 1.46 to 3.67) during the period of one-lung ventilation. In conclusion, a large V(T) and high P(aw) during one-lung ventilation were associated with an increased risk of post-pneumonectomy ALI / ARDS in primary lung cancer patients.
- Published
- 2009
49. The effects of desflurane and propofol-remifentanil on postoperative hepatic and renal functions after right hepatectomy in liver donors
- Author
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Gaab Soo Kim, Justin Sang Ko, In Sun Chung, Soo Joo Choi, Mikyung Yang, Myung Hee Kim, Jie Ae Kim, Hyun Sung Cho, Mi Sook Gwak, and Sangmin Maria Lee
- Subjects
Adult ,Male ,medicine.medical_treatment ,Remifentanil ,Renal function ,Liver transplantation ,Kidney ,Kidney Function Tests ,chemistry.chemical_compound ,Desflurane ,Liver Function Tests ,Piperidines ,Living Donors ,medicine ,Hepatectomy ,Humans ,Propofol ,Blood urea nitrogen ,Anesthetics ,Transplantation ,Creatinine ,Isoflurane ,Hepatology ,medicine.diagnostic_test ,business.industry ,Liver ,chemistry ,Anesthesia ,Anesthetics, Inhalation ,Female ,Surgery ,Liver function tests ,business ,Anesthetics, Intravenous ,medicine.drug - Abstract
Various volatile anesthetics have been used in hepatectomy in living donors, and their effects on major organs have been extensively evaluated. However, the impact of total intravenous anesthesia (TIVA) on postoperative liver and renal functions after large liver resections has been less extensively investigated than that of volatile agents. The aim of this study was to compare the postoperative hepatic and renal functions between volatile anesthesia with desflurane and TIVA with propofol-remifentanil in living donors undergoing right hepatectomy. Seventy adult patients were randomly allocated into 2 groups: the desflurane group (n = 35) and TIVA group (n = 35). Aspartate aminotransferase, alanine aminotransferase, prothrombin time (PT), albumin, total bilirubin (TB), blood urea nitrogen (BUN), creatinine (Cr), BUN/Cr ratio, estimated glomerular filtration rate (GFR), platelet count, and hemoglobin levels were analyzed in the preoperative period, immediately after the operation, and on the first, second, third, fifth, seventh, and thirtieth postoperative days (PODs). Most of the liver function test results were not significantly different between the 2 groups. However, PT (international normalized ratio) and TB were significantly greater on POD 5 in the TIVA group. Among the renal function tests, Cr was significantly higher and estimated GFR was significantly lower on POD 1 in the TIVA group. The platelet counts and hemoglobin levels were similar between the 2 groups. In conclusion, the results of our study suggest that living related donors for liver transplant may have a better outcome following anesthesia with desflurane. However, further testing will be necessary to prove this hypothesis.
- Published
- 2008
50. Effect of preoperative skull block on pediatric moyamoya disease
- Author
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Soo Joo Choi, Ik Soo Chung, Jie Ae Kim, Mi Sook Gwak, Jeong Jin Lee, Han Soo Kim, Jin Kyoung Kim, Hyung Jin Shin, and Hyun Joo Ahn
- Subjects
Male ,Methyl Ethers ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Methylprednisolone ,Central nervous system disease ,Sevoflurane ,Postoperative Complications ,Humans ,Medicine ,Normocapnia ,Moyamoya disease ,Child ,Bupivacaine ,Pain, Postoperative ,business.industry ,Vascular disease ,Skull ,Hemodynamics ,Delirium ,Nerve Block ,General Medicine ,Carbon Dioxide ,medicine.disease ,Surgery ,Emergence delirium ,Cerebrovascular Circulation ,Child, Preschool ,Anesthesia ,Anesthetics, Inhalation ,Nerve block ,Female ,Moyamoya Disease ,business ,Complication ,medicine.drug - Abstract
Object Stable hemodynamics, normocapnia, and adequate pain relief are considered important factors in the reduction of neurological complications in pediatric patients undergoing encephaloduroarteriomyosynangiosis (EDAMS) operations for the treatment of moyamoya disease. A preoperative skull block may reduce hemodynamic fluctuations and hypo- or hyperventilation due to emergence delirium or oversedation and provide adequate pain relief, thereby reducing postoperative morbidity. Methods Pediatric patients (age 3–13 years) undergoing EDAMS surgery for moyamoya disease were randomly divided into a nerve block (NB) group (18 cases) or control group (21 cases). The treatment group patients received a preoperative NB (0.25% 5–8 ml bupivacaine mixed with 20–40 mg methylprednisolone) targeting the supraorbital, supratrochlear, auriculotemporal, and posterior auricular nerves. Patients in the control group did not receive NB. General anesthesia with sevoflurane was induced in both groups. Results In the NB group, stable hemodynamic parameters were obtained with a lower sevoflurane concentration than in the control group. For delirious awakening, the odds ratio in the control group was 4.9 compared with the NB group. Pain and analgesic requirement were higher in the control patients than in the NB-treated patients during the postanesthesia care unit stay. However, the arterial CO2 tension in the postanesthesia care unit did not differ between the 2 groups. The odds ratio in the control group for the rate of morbidity (cerebral infarction and reversible ischemic neurological deficits) during the first 24 hours following the operation was 3.2 compared with the NB group. Conclusions The use of skull block during EDAMS surgery provided easy hemodynamic control, calm awakening, and better pain relief and may be related to the reduced postoperative morbidity.
- Published
- 2008
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