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Intracorporeal needle-based therapeutic ultrasound (NBTU) offers a minimally invasive approach for the thermal ablation of malignant brain tumors, including both primary and metastatic cancers. NBTU utilizes a high-frequency alternating electric field to excite a piezoelectric transducer, generating acoustic waves that cause localized heating and tumor cell ablation, and it provides a more precise ablation by delivering lower acoustic power doses directly to targeted tumors while sparing surrounding healthy tissue. Building on our previous work, this study introduces a database for optimizing pre-operative surgical planning by simulating ablation effects in varied tissue environments and develops an extended simulation model incorporating various tumor types and sizes to evaluate thermal damage under trans-tissue conditions. A comprehensive database is created from these simulations, detailing critical parameters such as CEM43 isodose maps, temperature changes, thermal dose areas, and maximum ablation distances for four directional probes. This database serves as a valuable resource for future studies, aiding in complex trajectory planning and parameter optimization for NBTU procedures. Moreover, a novel probe selection method is proposed to enhance pre-surgical planning, providing a strategic approach to selecting probes that maximize therapeutic efficiency and minimize ablation time. By avoiding unnecessary thermal propagation and optimizing probe angles, this method has the potential to improve patient outcomes and streamline surgical procedures. Overall, the findings of this study contribute significantly to the field of NBTU, offering a robust framework for enhancing treatment precision and efficacy in clinical settings., Comment: 8 pages, 17 figures, 2 tables

Intracorporeal needle-based therapeutic ultrasound (NBTU) is a minimally invasive option for intervening in malignant brain tumors, commonly used in thermal ablation procedures. This technique is suitable for both primary and metastatic cancers, utilizing a high-frequency alternating electric field (up to 10 MHz) to excite a piezoelectric transducer. The resulting rapid deformation of the transducer produces an acoustic wave that propagates through tissue, leading to localized high-temperature heating at the target tumor site and inducing rapid cell death. To optimize the design of NBTU transducers for thermal dose delivery during treatment, numerical modeling of the acoustic pressure field generated by the deforming piezoelectric transducer is frequently employed. The bioheat transfer process generated by the input pressure field is used to track the thermal propagation of the applicator over time. Magnetic resonance thermal imaging (MRTI) can be used to experimentally validate these models. Validation results using MRTI demonstrated the feasibility of this model, showing a consistent thermal propagation pattern. However, a thermal damage isodose map is more advantageous for evaluating therapeutic efficacy. To achieve a more accurate simulation based on the actual brain tissue environment, a new finite element method (FEM) simulation with enhanced damage evaluation capabilities was conducted. The results showed that the highest temperature and ablated volume differed between experimental and simulation results by 2.1884{\deg}C (3.71%) and 0.0631 cm$^3$ (5.74%), respectively. The lowest Pearson correlation coefficient (PCC) for peak temperature was 0.7117, and the lowest Dice coefficient for the ablated area was 0.7021, indicating a good agreement in accuracy between simulation and experiment., Comment: 9 pages, 9 figures, 7 tables

In this work, we develop an open-source surgical simulation environment that includes a realistic model obtained by MRI-scanning a physical phantom, for the purpose of training and evaluating a Learning from Demonstration (LfD) algorithm for autonomous suturing. The LfD algorithm utilizes Dynamic Movement Primitives (DMP) and Locally Weighted Regression (LWR), but focuses on the needle trajectory, rather than the instruments, to obtain better generality with respect to needle grasps. We conduct a user study to collect multiple suturing demonstrations and perform a comprehensive analysis of the ability of the LfD algorithm to generalize from a demonstration at one location in one phantom to different locations in the same phantom and to a different phantom. Our results indicate good generalization, on the order of 91.5%, when learning from more experienced subjects, indicating the need to integrate skill assessment in the future.

This work presents a new dialog dataset, CookDial, that facilitates research on task-oriented dialog systems with procedural knowledge understanding. The corpus contains 260 human-to-human task-oriented dialogs in which an agent, given a recipe document, guides the user to cook a dish. Dialogs in CookDial exhibit two unique features: (i) procedural alignment between the dialog flow and supporting document; (ii) complex agent decision-making that involves segmenting long sentences, paraphrasing hard instructions and resolving coreference in the dialog context. In addition, we identify three challenging (sub)tasks in the assumed task-oriented dialog system: (1) User Question Understanding, (2) Agent Action Frame Prediction, and (3) Agent Response Generation. For each of these tasks, we develop a neural baseline model, which we evaluate on the CookDial dataset. We publicly release the CookDial dataset, comprising rich annotations of both dialogs and recipe documents, to stimulate further research on domain-specific document-grounded dialog systems., Comment: The dataset and codes are available at https://github.com/YiweiJiang2015/CookDial

We consider the task of document-level entity linking (EL), where it is important to make consistent decisions for entity mentions over the full document jointly. We aim to leverage explicit "connections" among mentions within the document itself: we propose to join the EL task with that of coreference resolution (coref). This is complementary to related works that exploit either (i) implicit document information (e.g., latent relations among entity mentions, or general language models) or (ii) connections between the candidate links (e.g, as inferred from the external knowledge base). Specifically, we cluster mentions that are linked via coreference, and enforce a single EL for all of the clustered mentions together. The latter constraint has the added benefit of increased coverage by joining EL candidate lists for the thus clustered mentions. We formulate the coref+EL problem as a structured prediction task over directed trees and use a globally normalized model to solve it. Experimental results on two datasets show a boost of up to +5% F1-score on both coref and EL tasks, compared to their standalone counterparts. For a subset of hard cases, with individual mentions lacking the correct EL in their candidate entity list, we obtain a +50% increase in accuracy.

Music classification between music made by AI or human composers can be done by deep learning networks. We first transformed music samples in midi format to natural language sequences, then classified these samples by mLSTM (multiplicative Long Short Term Memory) + logistic regression. The accuracy of the result evaluated by 10-fold cross validation can reach 90%. Our work indicates that music generated by AI and human composers do have different characteristics, which can be learned by deep learning networks., Comment: in Chinese