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9 results on '"Jiang, Cheng-zhe"'

2. Research Progress on Nutrients of Artemisia argyi.

Author

Gao He-mei, Li Hong-mei, and Jiang Cheng-zhe

Subjects
PLANT nutrients, ARTEMISIA, HERBS, CARBOHYDRATES, PLANT proteins, AMINO acids, FLAVONOIDS, VITAMINS
Abstract

Artemisia argyi is a traditional Chinese herb, which is widely distributed in various areas in China. In recent years, due to the development of A. argyi related industries and the continuous improvement of people's health awareness, experts and scholars are concerned about the nutrients and effects of A. argyi. A. argyi is rich in carbohydrates, proteins, essential amino acids, fatty acids, minerals, vitamins, dietary fibers, flavonoids and other nutrients. It has the effects of antioxidant, anti-tumor, antibacterial, antiinflammatory, neuroprotection and immune regulations, and has been widely applied in the fields of COVID-19 prevention, food health care, food preservation and feed breeding, and has good development potential. This review summarized the research and application of A. argyi nutrients, in order to provide reference and application for further study. [ABSTRACT FROM AUTHOR]

Published
2023

4. Decursin Mediated Protection on Cisplatin-induced Nephrotoxicity in SD Rats and BDF1 Mice

Author

Han Ilhyun, Jiang Cheng-zhe, and Choung Se-young

Subjects
Cisplatin, Creatinine, business.industry, Pharmacology, medicine.disease, Nephrotoxicity, chemistry.chemical_compound, chemistry, Renal injury, Cisplatin induced nephrotoxicity, In vivo, medicine, Neoplasm, business, Adverse effect, medicine.drug
Abstract

Tisplatin is one of the valuable icancer agents against several types of neoplasm. However, nephrotoxicity is the major adverse effect representing in cisplatin therapy. In this study, the animal tests detecting protective effects of a natural compound, Decursin, on cisplatin-induced nephrotoxicity were examined by using in vivo model. Pretreatment Decursin 10, 20 and 40 mg · kg −1 at 48, 24 and 6 h, and administration of a single dose of Cisplatin 5.2 mg · kg −1 . Nephrotoxicity was evaluated by serum BUN and creatinine examination. There was significant difference in body weights, serum BUN and creatinine levels of the normal group. Based on the new understanding of the protective mechanisms of cisplatin-induced nephrotocivity, new strategies can be developed to prevent renal injury or to enhance recovery after cisplatin treatment.

Published
2012

8. Decursin Safety from Root of Angelica gigasin Rats

Author

Jiang, Cheng-zhe, Feng, Jin-man, Zhang, Jian-feng, Han, Ilhyun, and Choung, Seyoung

Abstract

The subacute intraperitoneal toxicity of decursin was investigated in Spargue-Dawly (SD) rats. The rats were treated with decursin at a dose of 125 and 250 mg · kg−1· day−1for 4 weeks. All animals were observed daily for clinical signs. Their body weights were recorded weekly, no mortality was observed in two doses of 125 and 250 mg · kg−1of decursin. There were no significant differences in the clinical observations, body weight, food and water consumption, hematology, blood chemistry, gross pathological examination or organ weight between control and treated animals of both sexes. In conclusion, no evidence of a subacute toxic potential was observed in this study and no indication for adverse effects was noted at a dose level of 250 mg · kg−1· day−1.

Published
2013
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9. Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice.

Author

Du Xiao F, Jiang CZ, Wu CF, Won EK, and Choung SY

Subjects
Alanine Transaminase blood, Animals, Antineoplastic Agents, Alkylating pharmacology, Cell Count, Cyclophosphamide pharmacology, Drug Synergism, Erythrocytes drug effects, Erythrocytes immunology, Female, Immunoglobulin E biosynthesis, Immunoglobulin E genetics, Immunoglobulin G biosynthesis, Immunoglobulin G genetics, Kidney Function Tests, Leukocytes drug effects, Liver Function Tests, Lymph Nodes immunology, Lymph Nodes pathology, Mice, Mice, Inbred BALB C, Panax toxicity, Plant Extracts pharmacology, Polysaccharides chemistry, Polysaccharides toxicity, Pyrrolidonecarboxylic Acid pharmacology, Pyrrolidonecarboxylic Acid toxicity, Spleen immunology, Spleen pathology, Thiazolidines toxicity, Thymus Gland immunology, Thymus Gland pathology, Adjuvants, Immunologic pharmacology, Antibody Formation drug effects, Immunosuppression Therapy, Panax chemistry, Polysaccharides pharmacology, Pyrrolidonecarboxylic Acid analogs & derivatives, Thiazolidines pharmacology
Abstract

We investigated the synergistic effect of pidotimod and red ginseng acidic polysaccharide (RGAP) from Panax ginseng C.A. Meyer on humoral immune response challenged by lipopolysaccharide (LPS) and sheep red blood cells (SRBC) in immunosuppressed mice. Combined treatment with pidotimod and RGAP significantly increased the number of plaque-forming cells in the spleen in response to both LPS and SRBC, while treatment with either pidotimod or RGAP individually had no such effect. IgG levels in serum were augmented for secondary responses to SRBC in co-treated mice, but not in mice treated with either drug alone. Microscopic studies revealed that architecture of the spleen, thymus, and lymph nodes was conserved. GPT and creatinine in serum as indicators of hepatic and renal functions showed no difference compared to the control group. These results indicate that combined treatment with pidotimod and RGAP has an immunostimulatory effect in a synergistic manner on antibody response to challenge with LPS and SRBC without toxic changes.

Published
2008

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