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In remote-sensing image processing tasks, images with higher resolution always result in better performance on downstream tasks, such as scene classification and object segmentation. However, objects in remote-sensing images often have low resolution and complex textures due to the imaging environment. Therefore, effectively reconstructing high-resolution remote-sensing images remains challenging. To address this concern, we investigate embedding context information and object priors from remote-sensing images into current deep learning super-resolution models. Hence, this paper proposes a novel remote-sensing image super-resolution method called Context-Guided Constrained Network (CGC-Net). In CGC-Net, we first design a simple but effective method to generate inverse distance maps from the remote-sensing image segmentation maps as prior information. Combined with prior information, we propose a Global Context-Constrained Layer (GCCL) to extract high-quality features with global context constraints. Furthermore, we introduce a Guided Local Feature Enhancement Block (GLFE) to enhance the local texture context via a learnable guided filter. Additionally, we design a High-Frequency Consistency Loss (HFC Loss) to ensure gradient consistency between the reconstructed image (HR) and the original high-quality image (HQ). Unlike existing remote-sensing image super-resolution methods, the proposed CGC-Net achieves superior visual results and reports new state-of-the-art (SOTA) performance on three popular remote-sensing image datasets, demonstrating its effectiveness in remote-sensing image super-resolution (RSI-SR) tasks.

Objective The aim of this study was to retrospective analysis of role of ductal glandular dysplasia as a risk factor in the development of carcinoma in adenomyomatous hyperplasia of the Vaterian system(AV).Methods Retrospective collection of data from patients who underwent surgery between January 2005 and December 2021, with a final pathological diagnosis of adenomyomatous hyperplasia (AH). Clinical data and pathological features of AV with or without glandular dysplasia were analyzed.Results Three of seventeen AH cases were associated with carcinoma (18%). Of three cases, two (12%) with the tumor lesions in the mucosal glands adjacent to the AH (cholangiocarcinoma and ampullary carcinoma), and one (6%) with carcinoma developed from AH itself in the ampulla of Vater. All carcinomas had adenomyomatous hyperplasia with nearby mucosal glandular dysplasia (MGD). The incidence of BTC or AC was higher in patients with concurrent AH and MGD compared to AH patients without MGD. The results show tendency toward statistical significance (P = 0.082). This difference was more obvious among AH with severe dysplasia compared to adenomyomatous hyperplasia with mild-moderate dysplasia (P = 0.018).Conclusion This study is the first to find that adenomyomatous hyperplasia of the Vaterian system is associated with ductal carcinoma and ampullary carcinoma. In AV, the mucosal glandular dysplasia is a risk factor for the development of malignancy. The underlying mechanism for carcinogenesis of the Vaterian system could be AH itself or its secretions stimulating mucosal glands hyperplasia, then mucosal glands dysplasia. AH of the Vaterian system may be a precancerous lesion.

This study investigated the characteristics of workplace violence (WPV) against Chinese healthcare staff and their casualties after severe physical violence (PV).We scrutinized medical WPV incidents reported online and analyzed information on timing, location, violence, criminal incentives, and casualties following severe PV in China from 2010 to 2020.WPVs were mostly committed by young and middle-aged male family members of the patients, especially in the emergency department (49.1%), and mostly associated with dissatisfaction with treatment effect (28.9%) in general. High medical costs (62.5%) were the leading cause of verbal violence (VV), whereas men predominantly committed PV (OR = 4.217, 95% CI: 1.439-12.359) owing to dissatisfaction with the healthcare staff's attitude (P 0.001). The victims were security personnel in most cases (81.1%). Nurses were generally more likely to experience PV (P 0.05), while doctors were more likely to experience lethal PV (OR = 4.732, 95% CI: 1.42-15.772), which mostly happened in oncology (P 0.05) and committed by visitors (P 0.001). Slight injuries and mortality were more likely to be inflicted by being rejected for unreasonable demands and disappointed with the treatment effect (P 0.05).Medical WPV has numerous reasons, locations, and diverse victims and offenders. Some severe WPVs have serious consequences. Therefore, it is recommended for the concerned authorities to adopt effective steps for appropriate legislative, security, and conflict-resolution measures.

Once the methane concentration reaches the explosion limit, it may be ignited by coal fires in methane-rich and coal combustion-prone longwall mining gobs. Therefore, the methane migration in the area of spontaneous combustion of coal is important for evaluating the safety risk and revealing the formation mechanism of methane explosions. A self-designed experimental platform of a longwall gob was applied to investigate the methane migration process induced by the spontaneous combustion of coal. The effect of temperature, and range of coal spontaneous combustion on the methane distribution was studied, and the potential area subject to a methane explosion was identified and calculated quantitatively. Furthermore, the methane movement near the area of spontaneously combusting coal was analyzed, and the mechanism of methane accumulation was proposed. The results illustrate that the changes in the temperature and the range of spontaneous combustion of coal affect the migration of the methane concentration in the gobs.

Relatively high torque ripple limits the further development of the switched reluctance machine, and the application of the ripple suppression method will reduce the efficiency of the system. To simultaneously improve the efficiency and torque ripple of the switched reluctance machine, a new commutation and online optimization strategy is proposed. According to the torque per ampere characteristics of the machine, two rotor position angles are defined, which are the boundaries for the high and low torque per ampere operation modes of the two adjacent phases, respectively, and for different operating modes, specific torque hysteresis control schemes are performed. Furthermore, an objective function is constructed with the efficiency and torque ripple coefficient, and during the operation of the machine, the defined boundary angles are online optimized by the genetic algorithm to maximize the value of the objective function. The effectiveness of the method is verified by detailed simulation and experiment under different operating conditions.

In order to explore the effects of high temperature (HT) and light on the physiological and biochemical aspects of macroalga Ulva prolifera, we cultured this species under two temperatures (20°C: low temperature, LT; 30°C: HT) and two light intensities (80 μmol m⁻² s⁻¹: low light, LL; 400 μmol m⁻² s⁻¹: high light, HL) for 5 days. It was found that (a) compared to 20°C, the chlorophyll a (Chl a) content was increased at 30°C under LL conditions, the relative growth rate (RGR) was significantly decreased at 30°C; (b) compared to LL treatment, HL significantly increased RGR but significantly decreased Chl a content; (c) LL‐grown U. prolifera at 30°C showed the highest photosynthetic oxygen evolution rate; however, there were no significant effects of temperature and light on the relative electron transport rate; (d) superoxide dismutase activity was significantly decreased by HL, but no significant effects of temperature were observed; and (e) compared to LL, HL significantly increased the soluble sugar content at 20°C, but significantly reduced at 30°C. These results showed that the inhibitory effects of HT can be offset by HL intensity.

The nicotinamide adenine dinucleotide (NAD+ )/Sirtuin (SIRT) system is linked to metabolic adaptation. This study aimed to determine the temporal profile of metabolic responses of the liver to cold exposure and changes in the hepatic NAD+ /SIRT system. Eight-week-old male C57BL/6 mice were individually housed in conventional cages under cold exposure (4 °C) for up to 5 days. Cold exposure decreased the hepatic triglyceride level and cholesterol level in mice by 1.7- and 1.6-fold, respectively. Lipogenic gene expression was persistently reduced, while gluconeogenic gene expression was transiently increased. Hepatic NAD+ /SIRT metabolism was induced during the 'cold remodeling' phase (days 1-3) and correlated with decreasing lipogenic and increasing gluconeogenic gene expression, contributing to the maintenance of whole-body lipid and glucose homeostasis.

Oxidative deterioration is a major issue limiting the utilisation of linseed oil. This study investigated the effect of electrospun guar gum (GG) fibrous mats with addition of natural antioxidants on the oxidative stability of linseed oil. As a new technology, electrospinning was chosen to prepare nanofibrous mats. Besides, tannic acid (TA) was used as natural antioxidants and water was used as a solvent. The synthesised fibrous were smooth under the electron microscope, which had no defect structure and relatively uniform diameter. Electrospun GG fibrous mats containing TA were added to the linseed oil and the same amount of TA powder was used for comparison, then stored at 60 °C for 30 days to monitor the oxidation of oil. Conjugated dienes, peroxide value, p-anisidine value, thiobarbituric acid and fatty acid composition were used as indicators of oxidative stability. It was shown that TA can delay primary and secondary oxidation and improve oxidation stability. In conclusion, electrospun TA fibrous mats can play a more effective role than adding TA alone in antioxidation of linseed oil, which had potential applications in oil preservation.

To evaluate whether programmed intermittent epidural bolus (PIEB) reduces the incidence of maternal intra-partum fever compared with continuous epidural infusion (CEI) during labor. Parturients were randomized to receive CEI (CEI group) or PIEB (PIEB group) with 10 ml per hour for epidural labor analgesia with 1500 subjects in each group. The maintaining dose of two groups is 0.08% ropivacaine with 0.4 μg/ml sufentanil, with patient-controlled epidural analgesia (PCEA) dose of 5 ml and lockout interval of 30 min. The incidence of maternal fever, pain score, epidural sensory levels, the number and proportion of PCEA demand, anesthetics consumption, satisfaction score, neonatal Apgar scale, and maternal and neonatal side effects were recorded. It was significantly lower of the incidence of maternal fever beginning at 4 h post-analgesia and continuing until delivery in the PIEB group than the CEI group (4 h: 2.6% vs. 4.2%; 5 h: 7.3% vs. 10.2%; delivery: 5.6% vs. 7.9%; 1 h post-delivery: 3.9% vs. 6.2%; 2 h post-delivery: 2.1 vs. 3.5%; total: 5.8% vs. 8.4% in PIEB and CEI, respectively). Compared with CEI group, pain scores at 3, 4, 5 h post-analgesia and delivery (3 h: 2 [1, 2] vs. 2 [1–3]; 4 h: 2 [2, 3] vs. 3 [2–4]; 5 h: 2 [2, 3] vs. 3 [2–4]; delivery: 3 [2–4] vs. 4 [3, 4] in PIEB and CEI, respectively), the number and proportion of PCEA demand (number: 0.7 ± 0.9 vs. 2.2 ± 1.9; proportion: 42.0% vs. 80.3% in PIEB and CEI, respectively), and anesthetics consumption significantly decreased in the PIEB group (Ropivacaine: 60 ± 13 mg vs. 76 ± 17 mg; Sufentanil: 26 ± 4 mg vs. 32 ± 6 mg in PIEB and CEI, respectively), without severe maternal and neonatal side effects and any difference in neonatal Apgar scale. The epidural sensory levels 2 h post-analgesia (2 h: 8[8, 9] vs. 9[8, 9] in PIEB and CEI) and satisfaction score (9 [9, 10] vs. 7 [6, 7] in PIEB and CEI) were significantly higher in the PIEB group compared with those in the CEI group. PIEB with 10 ml of 0.08% ropivacaine and 0.4 μg/ml sufentanil hourly provided a lower incidence of intra-partum fever with a better analgesic effect compared with CEI, without any severe maternal and neonatal adverse reactions.

Deep neural networks have made tremendous progress in 3D object detection, which is an important task especially in autonomous driving scenarios. Benefited from the breakthroughs in deep learning and sensor technologies, 3D object detection methods based on different sensors, such as camera and LiDAR, have developed rapidly. Meanwhile, more and more researches notice that the abundant information contained in the multi-view data can be used to obtain more accurate understanding of the 3D surrounding environment. Therefore, many sensor-fusion 3D object detection methods have been proposed. As safety is critical in autonomous driving and the deep neural networks are known to be vulnerable to adversarial examples with visually imperceptible perturbations, it is significant to investigate adversarial attacks for 3D object detection. Recent works have shown that both image-based and LiDAR-based networks can be attacked by the adversarial examples while the attacks to the sensor-fusion models, which tend to be more robust, haven't been studied. To this end, we propose a simple multi-view correlation based adversarial attack method for the camera-LiDAR fusion 3D object detection models and focus on the black-box attack setting which is more practical in real-world systems. Specifically, we first design a generative network to generate image adversarial examples based on an auxiliary image semantic segmentation network. Then, we develop a cross-view perturbation projection method by exploiting the camera-LiDAR correlations to map each image adversarial example to the space of the point cloud data to form the point cloud adversarial examples in the LiDAR view. Extensive experiments on the KITTI dataset demonstrate the effectiveness of the proposed method.

Reprogramming somatic cells into megakaryocytes (MKs) would provide a promising source of platelets. However, using a pharmacological approach to generate human MKs from somatic cells remains an unmet challenge. Here, we report that a combination of four small molecules (4M) successfully converted human cord blood erythroblasts (EBs) into induced MKs (iMKs). The iMKs could produce proplatelets and release functional platelets, functionally resembling natural MKs. Reprogramming trajectory analysis revealed an efficient cell fate conversion of EBs into iMKs by 4M via the intermediate state of bipotent precursors. 4M induced chromatin remodeling and drove the transition of transcription factor (TF) regulatory network from key erythroid TFs to essential TFs for megakaryopoiesis, including FLI1 and MEIS1. These results demonstrate that the chemical reprogramming of cord blood EBs into iMKs provides a simple and efficient approach to generate MKs and platelets for clinical applications.

Finite control set model predictive torque control (FCS-MPTC) strategy has been widely used in induction motor (IM) control due to its fast response characteristic. Although the dynamics of the FCS-MPTC method are highly commended, its steady-state performance—ripple deserves attention in the meantime. To improve the steady-state performance of the IM drives, this paper proposes an improved FCS-MPTC strategy, based on a novel fuzzy adaptive speed controller and an adaptive weighting factor, tuning strategy to reduce the speed, torque and flux ripples caused by different factors. Firstly, a discrete predicting plant model (PPM) with a new flux observer is established, laying the ground for achieving an FCS-MPTC algorithm accurately. Secondly, after analyzing the essential factors in establishing a fuzzy adaptive PI controller, with high ripple suppression capacity, an improved three-dimensional controller is designed. Simultaneously, the implementation procedures of the fuzzy adaptive PI controller-based FCS-MPTC are presented. Considering that a weighting factor must be employed in the cost function of an FCS-MPTC method, system ripples increase if the value of the weighting factor is inappropriate. Then, on that basis, a novel fuzzy adaptive theory-based weighting factor tuning strategy is proposed, with the real-time torque and flux performance balanced. Finally, both simulation and hardware-in-loop (HIL) test are conducted on a 1.1 kW IM drive to verify the proposed ripple reduction algorithms.

Air plasma is commonly used to treat water for activation or purification, and plasma-activated water (PAW) is a promising green disinfectant that has attracted much attention in recent years. However, either the O3 discharge mode or the NO x discharge mode of air plasma lacks efficiency for water activation, mainly due to the low solubility of O3, NO and NO2. The transition process between those two modes could produce high-valence NO x such as N2O5 which should be more efficient for water activation, but this process is not easily controlled and water activation by N2O5 has rarely been reported before. In this letter, N2O5 is found to be produced effectively and stably by mixing the effluent gases of a NO x mode air plasma, produced by gliding arc discharge, and an O3 mode air plasma, produced by dielectric barrier discharge. The mixed gas rich in N2O5 is found to be very efficient for water activation. A colony-forming unit reduction of nearly 6 logs was achieved for a methicillin-resistant Staphylococcus aureus suspension by using PAW treated by the mixed gas, and the high bactericidal effect of the PAW could persist for more than 1 h after the plasma activation. The main reactive species for the bactericidal effect in the PAW are discussed, and the chemical pathways for N2O5 production and its usage for water activation are illustrated.

Nicotinamide N-methyltransferase (NNMT) is a novel regulator, shown recently to regulate adipose tissue energy expenditure partly through changing NAD + content, which is essential for mitochondrial. We determine whether NNMT plays important role in energy metabolism during the beige adipogenesis in vivo and in vitro. Male C57BL/6 mice at 8 weeks old were exposed to 4 ℃ for 1, 2, 3, 4, and 5 days, respectively. Interscapular brown adipose tissue (iBAT), inguinal subcutaneous WAT (sWAT), and epididymal WAT (eWAT) were harvested for gene and protein expression analysis and the correlation analysis. In addition, cultured primary mice brown adipocyte (BA) and white adipocyte (WA) treated with or without β3-adrenoceptor agonist (CL316, 243) were also harvested for these analyses. A combination of NNMT and its related genetic (Nmnat1, Nampt, Cyp2e1, Nrk1, Cd38) and proteic analyses and also the NAD + levels demonstrated the dynamical and depot-specific remodeling of NAD metabolism in different adipose tissues in response to cold exposure. While upon CL316, 243 treatment, gene expression of Nnmt, Nampt, Cyp2e1, and Nrk1 was all significantly decreased in WA but not in BA. The increased NAD + amount in BA and WA during the beige adipogenesis was observed. Besides, it is demonstrated that the expression of NNMT both in sWAT and WA showed significant negative correlation with browning markers UCP-1 and PGC-1α at protein levels. Above all, NNMT was induced in WAT during the 'cold remodeling' phase and correlated negatively with the process of browning in sWAT and WA, indicating the specific role of NNMT in the regulation of energy homeostasis during the process of beige adipogenesis.

To carry out the direct instantaneous torque control (DITC) for the switched reluctance machine (SRM) with the low-resolution rotor position sensor, a dynamic acquisition method for the torque characteristics is proposed. The complete flux-linkage characteristics of the SRM are calculated based on the measured data at four specific rotor positions, and the torque characteristics are obtained with the spatial derivative of the coenergy. Detailed simulation and experiment are conducted, and the performances of the DITC with the resolver and photoelectric position sensor are comprehensively compared. Furthermore, to reveal the major causes of performance degradation, the influences of the rotor position estimation and torque characteristics calculation with the photoelectric position sensor are separately evaluated. The presented method, analysis and results are significant for the implementation of the DITC for the SRM with low-resolution rotor position sensor widely exists in some fields, such as the household appliances.