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NAD + /sirtuin metabolism is enhanced in response to coldāinduced changes in lipid metabolism in mouse liver
- Source :
- FEBS Letters. 594:1711-1725
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The nicotinamide adenine dinucleotide (NAD+ )/Sirtuin (SIRT) system is linked to metabolic adaptation. This study aimed to determine the temporal profile of metabolic responses of the liver to cold exposure and changes in the hepatic NAD+ /SIRT system. Eight-week-old male C57BL/6 mice were individually housed in conventional cages under cold exposure (4 °C) for up to 5 days. Cold exposure decreased the hepatic triglyceride level and cholesterol level in mice by 1.7- and 1.6-fold, respectively. Lipogenic gene expression was persistently reduced, while gluconeogenic gene expression was transiently increased. Hepatic NAD+ /SIRT metabolism was induced during the 'cold remodeling' phase (days 1-3) and correlated with decreasing lipogenic and increasing gluconeogenic gene expression, contributing to the maintenance of whole-body lipid and glucose homeostasis.
- Subjects :
- medicine.medical_specialty
Biophysics
Nicotinamide adenine dinucleotide
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Structural Biology
Internal medicine
Gene expression
Genetics
medicine
Glucose homeostasis
Molecular Biology
030304 developmental biology
0303 health sciences
biology
Cholesterol
030302 biochemistry & molecular biology
Lipid metabolism
Cell Biology
Metabolism
Endocrinology
chemistry
Sirtuin
biology.protein
NAD+ kinase
Subjects
Details
- ISSN :
- 18733468 and 00145793
- Volume :
- 594
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi...........707054649ead3e84c620cbb0fa7fc1d7