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Abstract Highly efficient multi-dimensional data storage and extraction are two primary ends for the design and fabrication of emerging optical materials. Although metasurfaces show great potential in information storage due to their modulation for different degrees of freedom of light, a compact and efficient detector for relevant multi-dimensional data retrieval is still a challenge, especially in complex environments. Here, we demonstrate a multi-dimensional image storage and retrieval process by using a dual-color metasurface and a double-layer integrated perovskite single-pixel detector (DIP-SPD). Benefitting from the photoelectric response characteristics of the FAPbBr2.4I0.6 and FAPbI3 films and their stacked structure, our filter-free DIP-SPD can accurately reconstruct different colorful images stored in a metasurface within a single-round measurement, even in complex environments with scattering media or strong background noise. Our work not only provides a compact, filter-free, and noise-robust detector for colorful image extraction in a metasurface, but also paves the way for color imaging application of perovskite-like bandgap tunable materials.

ObjectiveTo examine the status quo and influencing factors of nutrition and health knowledge among permanent residents aged 18 – 64 years in Hunan province in 2021. MethodsThe participants of the study were 4 351 permanent residents aged 18 – 64 years in 13 districts/counties of Hunan province. An on-site survey was conducted among the participants using a questionnaire designed for a national surveillance on nutrition and health knowledge in Chinese residents aged 18 – 64 years during April – May 2021. A participant′s awareness on nutrition and health knowledge was assessed according to the total scaled score ( ≥ 75 out of the full score of 100) for the questionnaire′s 20 items on dietary guidelines, food characteristics, nutrition and diseases, food choices, and food safety. Data analysis was performed with SPSS 22.0. ResultsThe mean score of nutrition and health knowledge questionnaire was 62.2 ± 12.4 for the 4 010 participants with eligible responses and 15.0% of the participants were assessed as having the awareness on nutrition and health knowledge. Of the participants, 77.4% reported obtaining nutrition and health knowledge through using mobile applications such as Wechat/MicroBlog/Tiktok/Kuaishou, followed by 53.5% and 43.4% reported obtaining the knowledge from television/radio programs and the communication with family members/relatives/friends. The results of logistic regression analysis showed that the participants with following characteristics were more likely to have the awareness on nutrition and health knowledge: being female ( versus male: OR = 1.319, 95%CI: 1.097 – 1.585), living in urban regions (versus living in rural regions: OR = 1.266, 95%CI: 1.044 – 1.536), with the education higher than primary school and below (junior middle school: OR = 2.257, 95%CI: 1.433 – 3.553; senior high school/technical secondary school/technical school education: OR = 3.916, 95%CI: 2.452 – 6.255; junior college/vocational college: OR = 7.859, 95%CI: 4.813 – 12.830; bachelor degree: OR = 11.943, 95%CI = 7.105 – 20.075; master degree or above: OR = 12.813, 95%CI: 3.929 – 41.788), and working in medical institutions (versus in other work units: OR = 1.849, 95%CI: 1.397 – 2.447) . ConclusionThe awareness rate of nutrition and health knowledge needs to be improved and the awareness is mainly influenced by gender, place of residence, education level and work unit among 18 – 64 years old residents in Hunan province.

Inhibition of epithelial ferroptosis in colonic tissues relieved clinical symptoms and improved endoscopic presentations in inflammatory bowel disease (IBD). Kumatakenin, the main ingredient of traditional Chinese medicinal cloves and Alpinia purpurata, is reported to possess therapeutic benefits. However, whether kumatakenin could inhibit ferroptosis and further alleviate colitis remains unclear. Here, we measured the effects of kumatakenin on ferroptosis of colonic epithelial cells from colitis mice. The colitis model was induced in mice by oral intake of 2.5% dextran sulfate sodium in drinking water. RNA sequencing was performed to investigate the mechanism underlying kumatakenin-mediated effects on colitis. The results showed that different doses of kumatakenin significantly alleviated symptoms and suppressed intestinal inflammation in the colitis mouse model. Kumatakenin supplementation decreased cellular iron levels and suppressed ferroptosis in epithelial cells from colitis mice. RNA sequencing, qPCR, and pharmacological inhibition assays showed that kumatakenin reduced cellular iron levels and suppressed ferroptosis in epithelial cells from colitis mice at least partially by upregulating expression of enolase (Eno-3). Furthermore, kumatakenin decreased iron levels in epithelial cells by modulating the Eno3-iron regulatory protein (IRP1) axis. Molecular docking results revealed that kumatakenin could bind Eno3 via hydrogen bonding with the amino acid residues Thr208, Val206, and Pro203. This work will provide a scientific basis for the clinical use of kumatakenin in the treatment of colitis.

Objective To understand the status of microbial contamination in the production of pre-cooked food, provide a basis for the sanitary control of pre-cooked food enterprises, and to make recommendations for the formulation of related product hygiene specifications and standards. Methods From the 70 pre-cooked food enterprises in Hunan Province, 5 samples were stratified to detect the settling microbe in ambient air, the total coliform and the total number of colonies in the contact surface, the adjacent contact surface, and pre-cooked food samples. Results The total coliform and the total number of colonies in the ambient air of medium-sized enterprises and the surfaces and pre-cooked vegetable samples was higher (P