26 results on '"Jiaan Hu"'
Search Results
2. Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis
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Qiqi Xue, Jie Wu, Yan Ren, Jiaan Hu, Ke Yang, and Jiumei Cao
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Sarcopenia ,Coronary artery disease ,Outcome ,Elderly ,meta-analysis ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background The development of sarcopenia is attributed to normal aging and factors like type 2 diabetes, obesity, inactivity, reduced testosterone levels, and malnutrition, which are factors of poor prognosis in patients with coronary artery disease (CAD). This study aimed to perform a meta-analysis to assess whether preoperative sarcopenia can be used to predict the outcomes after cardiac surgery in elderly patients with CAD. Methods PubMed, Embase, the Cochrane library, and Web of Science were searched for available papers published up to December 2020. The primary outcome was major adverse cardiovascular outcomes (MACE). The secondary outcomes were mortality and heart failure (HF)-related hospitalization. The random-effects model was used. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Results Ten studies were included, with 3707 patients followed for 6 months to 4.5 ± 2.3 years. The sarcopenia population had a higher rate of MACE compared to the non-sarcopenia population (HR = 2.27, 95%CI: 1.58–3.27, P
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- 2021
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3. Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
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Tingting Bai, Fang Fang, Feika Li, Yan Ren, Jiaan Hu, and Jiumei Cao
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Sarcopenia ,Handgrip strength ,Hypertension ,Older adults ,Meta-analysis ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background Sarcopenia, particularly low handgrip strength has been observed and correlated in association with hypertension among the older people. However, the results reported in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis to reveal the significant association between sarcopenia, handgrip strength, and hypertension in older adults. Methods PubMed, MEDLINE, Cochrane Library, and EMBASE databases were searched from inception to 15 November 2019 to retrieve the original research studies that addressed the association between sarcopenia, handgrip strength, and hypertension. All the relevant data were retrieved, analyzed, and summarized. Results Twelve articles met the inclusion criteria and a total of 21,301 participants were included in the meta-analysis. Eight eligible studies have reported the odd ratios (ORs) of hypertension and sarcopenia, and the ORs ranged from 0.41 to 4.38. When pooled the ORs together, the summarized OR was 1.29 [95% confidence interval (CI) =1.00–1.67]. The summarized OR for the Asian group 1.50 (95% CI = 1.35–1.67) was significantly higher than that of Caucasian group 1.08 (95% CI = 0.39–2.97). Eleven studies have provided the data on association between handgrip strength and hypertension. The overall OR and 95% CI was 0.99 (95% CI = 0.80–1.23), showing no significant association. Conclusion Sarcopenia was associated with hypertension, but no correlation was found between handgrip strength and hypertension in older adults.
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- 2020
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4. Generation of a human-derived induced pluripotent stem cell line (SIAISi012-A) from an 82-year-old healthy Chinese Han male
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Jinghui Guo, Fang Fang, Qiuting Dai, Wenxin Zhang, Weihao Di, Jiaan Hu, Jian Zhao, Jiumei Cao, and Ying Wang
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Biology (General) ,QH301-705.5 - Abstract
As the global median population age increases, neurological diseases associated with aging pose significant challenges to human health. Appropriate modeling systems can be useful tools to better understand the mechanism of age-related neuronal degeneration diseases. Here, we successfully generated an iPSC-derived modeling system of an 82-year-old healthy man, this newly established line showed that all pluripotent markers were expressed, and the differentiation potential was confirmed by trilineage differentiation. STR profiling proved the cell line identity, and G-binding showed the normal karyotype.
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- 2021
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5. Comprehensive analysis of ectopic mandibular third molar: a rare clinical entity revisited
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Yaping Wu, Yue Song, Rong Huang, Jiaan Hu, Xiaotong He, Yanling Wang, Guangchao Zhou, Chao Sun, Hongbing Jiang, Jie Cheng, and Dongmiao Wang
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Ectopic tooth ,Mandibular third molar ,Impacted third molar ,Panoramic radiography ,Specialties of internal medicine ,RC581-951 - Abstract
Abstract Background Ectopic mandibular third molar is a rare clinical entity with incompletely known etiology. Here, we sought to delineate its epidemiological, clinical and radiographic characteristics, and therapy by integrating and analyzing the cases treated in our institution together with previously reported cases. Method A new definition and classification for ectopic mandibular third molar was proposed based on its anatomic location on panoramic images. Thirty-eight ectopic mandibular third molars in 37 patients and 51 teeth in 49 patients were identified in our disease registry and from literature (1990–2016), respectively. These cases were further categorized and compared according to our classification protocol. The demographic, clinicopathological and radiographic data were collected and analyzed. Results These ectopic teeth were categorized into four levels, 33 in level I(upper ramus), 32 in level II (middle ramus), 15 in level III (mandibular angle) and 9 in level IV (mandibular body). The common clinical presentations included pain, swelling and limited mouth opening, although sometimes asymptomatic. Most teeth were associated with pathological lesions. Treatments included clinical monitor and surgical removal by intra- or extraoral approach with favorable outcomes. Clinical presentations and treatment options for these teeth were significantly associated with their ectopic locations as we classified. Conclusions Ectopic mandibular third molars are usually found in patients with middle ages and in upper and middle ramus of mandible. Surgery is preferred to remove these ectopic teeth and associated pathologies when possible.
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- 2017
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6. Comparison of cost-effectiveness and benefits of surgery-first versus orthodontics-first orthognathic correction of skeletal class III malocclusion
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Dongmiao Wang, Songsong Guo, Jian Cheng, Yue Jiang, Hongbin Jiang, Jiaan Hu, and Sheng Li
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Orthodontics ,Cost–benefit analysis ,business.industry ,Cost effectiveness ,Retrospective cohort study ,030206 dentistry ,Cost-effectiveness analysis ,Skeletal class ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,Quality of life ,030220 oncology & carcinogenesis ,Operating time ,Medicine ,Surgery ,Oral Surgery ,Malocclusion ,business - Abstract
The aim of this study was to compare the costs and benefits of surgery-first (SF) and orthodontics-first (OF) approaches in patients with skeletal class III malocclusion. This retrospective study recruited 54 patients who received combined orthognathic-orthodontic treatment via SF or OF approach. Data collected included orthodontic time, operating time, hospital stay, and detailed expenditures. Effectiveness was defined as quality of life, assessed by Orthognathic Quality of Life Questionnaire (OQLQ-22) before and 1 year after treatment. Cost-effectiveness was measured by incremental cost-effectiveness ratio (ICER) and incremental time-effectiveness ratio (ITER). The duration of SF was shorter than that of OF, due to a reduced orthodontic time (P=0.003). The operating time was longer with SF than with OF (P=0.015). There was no significant difference in hospital stay (P=0.868), cost of hospitalization (P=0.924) or orthodontics (P=0.171), or OQLQ score (P=0.41) between the two approaches. Cost-effectiveness analyses revealed a reduction in cost of US$ 6.43/OQLQ point and reduction in time of 8.60 months/OQLQ point gained by SF versus OF. The study findings revealed that the total treatment time was significantly shorter with SF than with OF, although the two approaches did not differ significantly in terms of total cost (P=0.979). Further studies on the cost-effectiveness of the two approaches in different healthcare systems across diverse countries are warranted.
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- 2021
7. Patterns of lingual split and lateral bone cut end and their associations with neurosensory disturbance after bilateral sagittal split osteotomy
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Dongmiao Wang, Hongbin Jiang, Jiaan Hu, Jian Cheng, Hua Yuan, and Yue Song
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Chin ,Cone beam computed tomography ,Disturbance (geology) ,Mandibular Nerve ,Osteotomy, Sagittal Split Ramus ,Lower lip ,Sagittal split osteotomy ,Mandible ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,medicine ,Humans ,In patient ,Vertical fracture ,Retrospective Studies ,Orthodontics ,business.industry ,030206 dentistry ,Cone-Beam Computed Tomography ,stomatognathic diseases ,medicine.anatomical_structure ,Skeletal malocclusion ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Trigeminal Nerve Injuries ,Surgery ,Oral Surgery ,business - Abstract
The purpose of this study was to characterize the patterns of lingual split and lateral bone cut end (LBCE) after bilateral sagittal split osteotomy (BSSO) in patients and identify their associations with postoperative neurosensory disturbance. This retrospective cohort study recruited 273 patients with skeletal malocclusion who received BSSO. The postoperative cone beam computed tomography data were reconstructed to three-dimensionally view the patterns of lingual split and LBCE. Associations between lingual split and LBCE and their effects on neurosensory disturbance in the lower lip and chin were determined. Six types of lingual split and three types of LBCE were defined based on three-dimensional images. Type I lingual split as a vertical fracture line to the inferior mandibular border was the most common (40.29%). Inferior LBCE was the most prevalent, followed by lingual and buccal types. Significant associations among lingual split, LBCE and skeletal deformities were found (P 0.05). However, patterns of lingual split and LBCE were not associated with the incidence of neurosensory disturbance. Patterns of lingual split after BSSO significantly associated with types of LBCE and dentomaxillofacial deformities, but not with postoperative neurosensory disturbance.
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- 2020
8. Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis
- Author
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Yan Ren, Jiaan Hu, Qiqi Xue, Jiumei Cao, Ke Yang, and Jie Wu
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Sarcopenia ,medicine.medical_specialty ,Population ,Type 2 diabetes ,Cochrane Library ,Coronary artery disease ,Elderly ,Internal medicine ,Humans ,Medicine ,education ,Aged ,Proportional Hazards Models ,Outcome ,education.field_of_study ,business.industry ,Research ,Hazard ratio ,RC952-954.6 ,medicine.disease ,meta-analysis ,Diabetes Mellitus, Type 2 ,Geriatrics ,Meta-analysis ,Geriatrics and Gerontology ,business ,human activities ,Mace - Abstract
Background The development of sarcopenia is attributed to normal aging and factors like type 2 diabetes, obesity, inactivity, reduced testosterone levels, and malnutrition, which are factors of poor prognosis in patients with coronary artery disease (CAD). This study aimed to perform a meta-analysis to assess whether preoperative sarcopenia can be used to predict the outcomes after cardiac surgery in elderly patients with CAD. Methods PubMed, Embase, the Cochrane library, and Web of Science were searched for available papers published up to December 2020. The primary outcome was major adverse cardiovascular outcomes (MACE). The secondary outcomes were mortality and heart failure (HF)-related hospitalization. The random-effects model was used. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Results Ten studies were included, with 3707 patients followed for 6 months to 4.5 ± 2.3 years. The sarcopenia population had a higher rate of MACE compared to the non-sarcopenia population (HR = 2.27, 95%CI: 1.58–3.27, P 2 = 60.0%, Pheterogeneity = 0.02). The association between sarcopenia and MACE was significant when using the psoas muscle area index (PMI) to define sarcopenia (HR = 2.86, 95%CI: 1.84–4.46, P 2 = 0%, Pheterogeneity = 0.604). Sarcopenia was not associated with higher late mortality (HR = 2.15, 95%CI: 0.89–5.22, P = 0.090; I2 = 91.0%, Pheterogeneity P = 0.792; I2 = 90.5%, Pheterogeneity = 0.001), and death, HF-related hospitalization (HR = 1.37, 95%CI: 0.59–3.16, P = 0.459; I2 = 62.0%, Pheterogeneity = 0.105). The sensitivity analysis revealed no outlying study in the analysis of the association between sarcopenia and MACE after coronary intervention. Conclusion Sarcopenia is associated with poor MACE outcomes in patients with CAD. The results could help determine subpopulations of patients needing special monitoring after CAD surgery. The present study included several kinds of participants; although non-heterogeneity was found, interpretation should be cautious.
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- 2021
9. Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited
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Linhong Xu, Yaqing Zhu, Jie Cheng, Wei Zhang, Lei Sang, Jiaan Hu, and Yibin Dai
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medicine.medical_specialty ,business.industry ,medicine.disease ,Malignancy ,Dermatology ,Disease registry ,Otorhinolaryngology ,Epidemiology ,Carcinosarcoma ,medicine ,Sarcomatoid carcinoma ,business ,General Dentistry ,Pathological ,Spindle cell carcinoma ,Rare disease - Abstract
OBJECTIVE The present study was aimed to comprehensively characterize the epidemiological, clinicopathological characteristics, treatments, and prognosis of intraoral spindle cell carcinoma (SpCC). MATERIALS AND METHODS Patients diagnosed with intraoral SpCC at our institution in the past 15 years (2005-2019) were screened from inpatient disease registry. All relevant data concerning patients with intraoral SpCC were retrieved. Previous reports about intraoral SpCC with adequate clinicopathological data in both English literature and Chinese literature were collected. Eligible cases were further reviewed and pooled for statistical analyses. RESULTS Six patients (5 females and 1 male; average age: 59 years) with intraoral SpCC were histopathologically diagnosed and surgically treated at our institution. The literature review identified another 63 published cases from 34 articles. Most cases were presented in the fifth to seventh decade of life with a male preponderance. Gingiva (23/69, 33.3%) was the most common site followed by the tongue (19/69, 27.5%) and buccal mucosa (8/69, 11.6%). Complete surgical ablation remains the primary treatment option. Tumor size, pathological grades, cervical node metastasis, and distant metastasis were significantly associated with reduced survival. CONCLUSIONS Intraoral SpCC is an uncommon and aggressive malignancy with dismal prognosis. Much attention and effort are needed to characterize this rare entity and improve its clinical outcomes.
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- 2021
10. Empagliflozin attenuating renal interstitial fibrosis in diabetic kidney disease by inhibiting lymphangiogenesis and lymphatic endothelial-to-mesenchymal transition via the VEGF-C/VEGFR3 pathway
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Jiaan Huang, Yan Liu, Mengting Shi, Xiaoyun Zhang, Yan Zhong, Shuai Guo, Yun Ma, Limin Pan, Fan Yang, and Yuehua Wang
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Diabetic kidney disease ,Empagliflozin ,EndMT ,Inflammation ,Lymphangiogenesis ,Renal interstitial fibrosis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Renal interstitial fibrosis (RIF) is a significant pathological change in diabetic kidney disease (DKD) that can be induced by endothelial-to-mesenchymal transition (EndMT). Lymphangiogenesis, mediated by the vascular endothelial growth factor-C (VEGF-C)/vascular endothelial growth factor receptor-3 (VEGFR-3) pathway, plays a crucial role in the development of RIF in DKD. Although numerous studies have demonstrated the efficacy of empagliflozin in treating renal injury, its effects on lymphangiogenesis in DKD-related RIF and the underlying mechanisms remain unclear. In the present study, significant lymphangiogenesis was assessed in the renal interstitium of patients with DKD. We subsequently explored the relationship between DKD-related RIF and lymphangiogenesis in mouse models, high-glucose (HG)-stimulated renal HK-2 cell lines, and human lymphatic endothelial cells (hLECs). Additionally, we evaluated the effects of empagliflozin on these processes. The results revealed that HG induces lymphangiogenesis, which exacerbates RIF by promoting inflammatory responses. Furthermore, hLECs directly contributed to the progression of DKD-related RIF through EndMT. Further analysis revealed that tubular epithelial cells (TECs) act as effector cells for VEGF-C, with the epithelial-to-mesenchymal transition (EMT) of TECs occurring concurrently with the EndMT of lymphatic vessels. Empagliflozin inhibited RIF in DKD by suppressing the VEGF-C/VEGFR3 pathway and reducing lymphangiogenesis. In conclusion, this study elucidates the interplay between lymphangiogenesis, EndMT, and RIF in DKD and provides new insights into the mechanism by which empagliflozin treats DKD.
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- 2024
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11. Generation of a human-derived induced pluripotent stem cell line (SIAISi012-A) from an 82-year-old healthy Chinese Han male
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Jiumei Cao, Fang Fang, Jinghui Guo, Ying Wang, Weihao Di, Jiaan Hu, Wenxin Zhang, Jian Zhao, and Qiuting Dai
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0301 basic medicine ,Male ,China ,Population ,Induced Pluripotent Stem Cells ,Biology ,Cell Line ,03 medical and health sciences ,Human health ,0302 clinical medicine ,Humans ,Neuronal degeneration ,Chinese han ,Induced pluripotent stem cell ,education ,lcsh:QH301-705.5 ,Aged, 80 and over ,education.field_of_study ,Mechanism (biology) ,Karyotype ,Cell Differentiation ,Cell Biology ,General Medicine ,030104 developmental biology ,lcsh:Biology (General) ,Cell culture ,Immunology ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
As the global median population age increases, neurological diseases associated with aging pose significant challenges to human health. Appropriate modeling systems can be useful tools to better understand the mechanism of age-related neuronal degeneration diseases. Here, we successfully generated an iPSC-derived modeling system of an 82-year-old healthy man, this newly established line showed that all pluripotent markers were expressed, and the differentiation potential was confirmed by trilineage differentiation. STR profiling proved the cell line identity, and G-binding showed the normal karyotype.
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- 2021
12. IDDF2020-ABS-0111 Does frailty predict postoperative outcomes in geriatric patients receiving surgery for colorectal cancer? A systematic review and meta-analysis
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Li Xie, Jiaan Hu, Jean Woo, Qingqing Qiu, Xiao-Bo Yang, Li-Fen Yu, Chen-Ying Xu, and Jiumei Cao
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medicine.medical_specialty ,Inpatient mortality ,Colorectal cancer ,business.industry ,MEDLINE ,Postoperative complication ,Odds ratio ,medicine.disease ,Surgery ,Risk Estimate ,Meta-analysis ,medicine ,In patient ,business - Abstract
Background Surgery remains the mainstay of colorectal cancer (CRC) and substantially reduces cancer-related morbidity and mortality. Frailty is defined as a biological syndrome, reflecting a state of impaired homeostatic reserve and predisposing to rehospitalisations and deaths in older individuals. Preoperative assessment for frailty is critically important in risk stratification and clinical decision-making. In this systematic review and meta-analysis, we aimed to quantitatively summarise the effect of frailty on postoperative outcomes in geriatric patients receiving surgery for CRC. Methods A systematic literature search was conducted in MEDLINE, Cochrane and EMBASE from inception to 30 April 2020. Fully published articles reporting risk estimate(s) of frailty on postoperative complication(s), readmission and/or mortality in patients aged ≥65 years who received surgery for CRC were eligible for qualitative and quantitative analyses. Results Across 10 articles of 9 unique studies (n = 69332) that were eventually included in the systematic review and meta-analysis, overall prevalence of frailty was 23.0% (95% CI: 11–43%, I2 = 100%). Odds ratios (ORs) on overall and severe postoperative complications were respectively increased by 2.36- (95% CI: 1.66–3.35, P Conclusions In the studies reviewed, frailty appeared to be associated with increased risks for postoperative complications, readmission and mortality during 12 months in patients aged ≥65 years who received surgery for CRC. Nevertheless, no significant association between frailty and 30-day/inpatient mortality was observed.
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- 2020
13. Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
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Feika Li, Jiumei Cao, Yan Ren, Tingting Bai, Fang Fang, and Jiaan Hu
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medicine.medical_specialty ,Sarcopenia ,medicine.medical_treatment ,MEDLINE ,lcsh:Geriatrics ,Cochrane Library ,Original research ,Handgrip strength ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Odds Ratio ,Humans ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Rehabilitation ,Hand Strength ,business.industry ,medicine.disease ,Confidence interval ,body regions ,lcsh:RC952-954.6 ,Meta-analysis ,Older adults ,Hypertension ,Geriatrics and Gerontology ,Older people ,business ,human activities ,030217 neurology & neurosurgery ,Research Article - Abstract
Background Sarcopenia, particularly low handgrip strength has been observed and correlated in association with hypertension among the older people. However, the results reported in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis to reveal the significant association between sarcopenia, handgrip strength, and hypertension in older adults. Methods PubMed, MEDLINE, Cochrane Library, and EMBASE databases were searched from inception to 15 November 2019 to retrieve the original research studies that addressed the association between sarcopenia, handgrip strength, and hypertension. All the relevant data were retrieved, analyzed, and summarized. Results Twelve articles met the inclusion criteria and a total of 21,301 participants were included in the meta-analysis. Eight eligible studies have reported the odd ratios (ORs) of hypertension and sarcopenia, and the ORs ranged from 0.41 to 4.38. When pooled the ORs together, the summarized OR was 1.29 [95% confidence interval (CI) =1.00–1.67]. The summarized OR for the Asian group 1.50 (95% CI = 1.35–1.67) was significantly higher than that of Caucasian group 1.08 (95% CI = 0.39–2.97). Eleven studies have provided the data on association between handgrip strength and hypertension. The overall OR and 95% CI was 0.99 (95% CI = 0.80–1.23), showing no significant association. Conclusion Sarcopenia was associated with hypertension, but no correlation was found between handgrip strength and hypertension in older adults.
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- 2020
14. Additional file 1 of Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
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Tingting Bai, Fang, Fang, Feika Li, Ren, Yan, Jiaan Hu, and Jiumei Cao
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mental disorders ,education ,human activities - Abstract
Additional file 1: Supplementary Figure 1. Funnel plot for the overall odds ratio of hypertension among sarcopenia and non- sarcopenia patients. Supplementary Figure 2. Funnel plot for the odds ratio of handgrip strength among hypertension and non-hypertension patients. Supplementary Figure 3. Summarized overall odds ratio of underweight or normal body mass index (BMI) in patients. Supplementary Figure 4. Summarized overall odds ratio of overweight or obese body mass index in patients.
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- 2020
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15. Additional file 3 of Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
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Tingting Bai, Fang, Fang, Feika Li, Ren, Yan, Jiaan Hu, and Jiumei Cao
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Data_FILES - Abstract
Additional file 3. Search strategy.
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- 2020
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16. Additional file 2 of Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
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Tingting Bai, Fang, Fang, Feika Li, Ren, Yan, Jiaan Hu, and Jiumei Cao
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Additional file 2: Supplementary Table 1. Demographic and clinical characteristics of the subjects included in studies that focused on sarcopenia. Supplementary Table 2. Demographic and clinical characteristics of the subjects included in studies that focused on handgrip strength. Supplementary Table 3. Quality assessment of included studies by Newcastle-Ottawa Scale. Supplementary Table 4. Publication bias of summarized outcome.
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- 2020
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17. N6-methyladenosine RNA methylation in diabetic kidney disease
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Jiaan Huang, Fan Yang, Yan Liu, and Yuehua Wang
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Diabetic kidney disease ,N6-methyladenosine methylation ,Non-coding RNAs ,Glycolipid metabolism ,Hyperglycemic memory ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes, and hyperglycemic memory associated with diabetes carries the risk of disease occurrence, even after the termination of blood glucose injury. The existence of hyperglycemic memory supports the concept of an epigenetic mechanism involving n6-methyladenosine (m6A) modification. Several studies have shown that m6A plays a key role in the pathogenesis of DKD. This review addresses the role and mechanism of m6A RNA modification in the progression of DKD, including the regulatory role of m6A modification in pathological processes, such as inflammation, oxidative stress, fibrosis, and non-coding (nc) RNA. This reveals the importance of m6A in the occurrence and development of DKD, suggesting that m6A may play a role in hyperglycemic memory phenomenon. This review also discusses how some gray areas, such as m6A modified multiple enzymes, interact to affect the development of DKD and provides countermeasures. In conclusion, this review enhances our understanding of DKD from the perspective of m6A modifications and provides new targets for future therapeutic strategies. In addition, the insights discussed here support the existence of hyperglycemic memory effects in DKD, which may have far-reaching implications for the development of novel treatments. We hypothesize that m6A RNA modification, as a key factor regulating the development of DKD, provides a new perspective for the in-depth exploration of DKD and provides a novel option for the clinical management of patients with DKD.
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- 2024
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18. Comprehensive analysis of 225 Castleman’s diseases in the oral maxillofacial and neck region: a rare disease revisited
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Jiaan Hu, Yaping Wu, Xiaotong He, Wei Zhang, Qiong Wang, Yanling Wang, Jie Cheng, Dongmiao Wang, and Bin Qi
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Adult ,Male ,China ,medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Disease ,03 medical and health sciences ,Rare Diseases ,0302 clinical medicine ,Disease registry ,Epidemiology ,medicine ,Humans ,030223 otorhinolaryngology ,General Dentistry ,Pathological ,Chemotherapy ,business.industry ,Castleman Disease ,Middle Aged ,Dermatology ,Systematic review ,030220 oncology & carcinogenesis ,Female ,Radiology ,business ,Head ,Neck ,Rare disease - Abstract
The aim of the present study was to comprehensively summarize the epidemiological, clinicopathological characteristics, treatments as well as prognosis of Castleman’s disease (CD) identified in the oral maxillofacial and neck region. Patients with CD in the oral maxillofacial and neck were retrieved from disease registry at our institution from Jan. 1990 to Dec. 2015. Systematic reviews from both English and Chinese literature were performed to collect the detailed information about the oral maxillofacial and neck CD. The epidemiological, clinicopathological data and treatment outcomes were further statistically analyzed. Four patients with the oral maxillofacial and neck CD were identified and histologically confirmed as hyaline-vascular type. They underwent surgical excision without recurrence during the follow-up. Systematic literature reviews identified 221 cases from 123 eligible articles which satisfied the inclusion criteria. In 225 patients, most patients were diagnosed as unicentric (207) or hyaline-vascular type (205) of CD and identified in the neck, and treated by surgical resection with good prognosis. In contrast, the minority of patients was multicentric or plasma-cell/mixed type and treated by chemotherapy with inferior outcomes. Kaplan-Meir analyses revealed that both clinical and pathological types were significantly associated with patients’ overall survival. Although rare, most cases of the oral maxillofacial neck CD are found in adults and classified as unicentric and hyaline-vascular type of CD. Complete surgical excision is preferred with favorable prognosis for unicentric disease, whereas chemotherapy is usually exploited for multicentric disease with inferior outcomes. These data provide comprehensive information about the epidemiology, clinicopathological features, treatments, and outcomes of the oral maxillofacial and neck CD.
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- 2017
19. Comprehensive analysis of ectopic mandibular third molar: a rare clinical entity revisited
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Rong Huang, Yue Song, Yaping Wu, Jie Cheng, Guangchao Zhou, Dongmiao Wang, Xiaotong He, Yanling Wang, Hongbing Jiang, Chao Sun, and Jiaan Hu
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Molar ,Adult ,Male ,medicine.medical_specialty ,lcsh:Specialties of internal medicine ,Radiography ,Dentistry ,Mandible ,Choristoma ,Asymptomatic ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Rare Diseases ,stomatognathic system ,lcsh:RC581-951 ,Radiography, Panoramic ,medicine ,Humans ,Registries ,General Dentistry ,Retrospective Studies ,business.industry ,Research ,Incidence ,Tooth, Impacted ,Retrospective cohort study ,030206 dentistry ,Middle Aged ,Mandibular third molar ,stomatognathic diseases ,Ectopic tooth ,Treatment Outcome ,Otorhinolaryngology ,Impacted third molar ,Panoramic radiography ,030220 oncology & carcinogenesis ,Tooth Extraction ,Oral and maxillofacial surgery ,Etiology ,Female ,Molar, Third ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Background Ectopic mandibular third molar is a rare clinical entity with incompletely known etiology. Here, we sought to delineate its epidemiological, clinical and radiographic characteristics, and therapy by integrating and analyzing the cases treated in our institution together with previously reported cases. Method A new definition and classification for ectopic mandibular third molar was proposed based on its anatomic location on panoramic images. Thirty-eight ectopic mandibular third molars in 37 patients and 51 teeth in 49 patients were identified in our disease registry and from literature (1990–2016), respectively. These cases were further categorized and compared according to our classification protocol. The demographic, clinicopathological and radiographic data were collected and analyzed. Results These ectopic teeth were categorized into four levels, 33 in level I(upper ramus), 32 in level II (middle ramus), 15 in level III (mandibular angle) and 9 in level IV (mandibular body). The common clinical presentations included pain, swelling and limited mouth opening, although sometimes asymptomatic. Most teeth were associated with pathological lesions. Treatments included clinical monitor and surgical removal by intra- or extraoral approach with favorable outcomes. Clinical presentations and treatment options for these teeth were significantly associated with their ectopic locations as we classified. Conclusions Ectopic mandibular third molars are usually found in patients with middle ages and in upper and middle ramus of mandible. Surgery is preferred to remove these ectopic teeth and associated pathologies when possible.
- Published
- 2017
20. The effect of peak serum estradiol level during ovarian stimulation on cumulative live birth and obstetric outcomes in freeze-all cycles
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Jiaan Huang, Yao Lu, Yaqiong He, Yuan Wang, Qinling Zhu, Jia Qi, Ying Ding, Hanting Zhao, Ziyin Ding, and Yun Sun
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estradiol ,cumulative live birth ,freeze-all ,embryo transfer ,obstetric outcome ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ObjectiveTo determine whether the peak serum estradiol (E2) level during ovarian stimulation affects the cumulative live birth rate (CLBR) and obstetric outcomes in freeze-all cycles.MethodsThis retrospective cohort study involved patients who underwent their first cycle of in vitro fertilization followed by a freeze-all strategy and frozen embryo transfer cycles between January 2014 and June 2019 at a tertiary care center. Patients were categorized into four groups according to quartiles of peak serum E2 levels during ovarian stimulation (Q1-Q4). The primary outcome was CLBR. Secondary outcomes included obstetric and neonatal outcomes of singleton and twin pregnancies. Poisson or logistic regression was applied to control for potential confounders for outcome measures, as appropriate. Generalized estimating equations were used to account for multiple cycles from the same patient for the outcome of CLBR.Result(s)A total of 11237 patients were included in the analysis. Cumulatively, live births occurred in 8410 women (74.8%). The live birth rate (LBR) and CLBR improved as quartiles of peak E2 levels increased (49.7%, 52.1%, 54.9%, and 56.4% for LBR; 65.1%, 74.3%, 78.4%, and 81.6% for CLBR, from the lowest to the highest quartile of estradiol levels, respectively, P
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- 2023
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21. Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome
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Qinling Zhu, Yue Yao, Lizhen Xu, Hasiximuke Wu, Wangsheng Wang, Yaqiong He, Yuan Wang, Yao Lu, Jia Qi, Ying Ding, Xinyu Li, Jiaan Huang, Hanting Zhao, Yanzhi Du, Kang Sun, and Yun Sun
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Serum amyloid A1 ,Polycystic ovary syndrome ,Insulin resistance ,Granulosa cells ,Inflammation ,Gynecology and obstetrics ,RG1-991 ,Reproduction ,QH471-489 - Abstract
Abstract Background Insulin resistance (IR) contributes to ovarian dysfunctions in polycystic ovarian syndrome (PCOS) patients. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver in response to inflammation. In addition to its role in inflammation, SAA1 may participate in IR development in peripheral tissues. Yet, expressional regulation of SAA1 in the ovary and its role in the pathogenesis of ovarian IR in PCOS remain elusive. Methods Follicular fluid, granulosa cells and peripheral venous blood were collected from PCOS and non-PCOS patients with and without IR to measure SAA1 abundance for analysis of its correlation with IR status. The effects of SAA1 on its own expression and insulin signaling pathway were investigated in cultured primary granulosa cells. Results Ovarian granulosa cells were capable of producing SAA1, which could be induced by SAA1 per se. Moreover, the abundance of SAA1 significantly increased in granulosa cells and follicular fluid in PCOS patients with IR. SAA1 treatment significantly attenuated insulin-stimulated membrane translocation of glucose transporter 4 and glucose uptake in granulosa cells through induction of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression with subsequent inhibition of Akt phosphorylation. These effects of SAA1 could be blocked by inhibitors for toll-like receptors 2/4 (TLR 2/4) and nuclear factor kappa light chain enhancer of activated B (NF-κB). Conclusions Human granulosa cells are capable of feedforward production of SAA1, which significantly increased in PCOS patients with IR. Excessive SAA1 reduces insulin sensitivity in granulosa cells via induction of PTEN and subsequent inhibition of Akt phosphorylation upon activation of TLR2/4 and NF-κB pathway. These findings highlight that elevation of SAA1 in the ovary promotes the development of IR in granulosa cells of PCOS patients.
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- 2022
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22. Gefitinib, an EGFR tyrosine kinase inhibitor, activates autophagy through AMPK in human lung cancer cells
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Zhihong, Xu, Junbiao, Hang, Jiaan, Hu, and Beili, Gao
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Lung Neoplasms ,Cell Line, Tumor ,Autophagy ,Quinazolines ,Humans ,Antineoplastic Agents ,Gefitinib ,AMP-Activated Protein Kinases ,Protein Kinase Inhibitors - Abstract
To investigate the effects of autophagy on growth inhibition by gefitinib in non-small cell lung cancer (NSCLC) cell lines and its probable mechanism.The mRNA and protein levels of Beclin 1, authophagy related 5 (Atg5) and Atg7 were assessed. H460 and Calu6 NSCLC cell lines were transfected with plasmids expressing green fluorescent protein (GFP)-LC3 and the formation of autophagosome was monitored under fluorescent microscope. In addition, H460 cells were treated with agonists of autophagy (everolimus and 3-methyladenine/ 3MA), AMP-activated protein kinase (AMPK) inhibitor (Compound C) and gefitinib, respectively. Cells were stained and studied under microscope. Cell colonies were counted and growth inhibition was calculated. Phosphorylated acetyl-Coenzyme A carboxylase (ACC) and AMPK were detected. Moreover, H460 cells were transfected with small interfering RNA (siRNA) against AMPK2 subunit and AMPK 2 was knocked down.LCII was accumulated to a higher level after treatment with gefitinib than that without addition of gefitinib, and gefitinib increased GFP punctuated cells. Besides, everolimus enhanced the autophagic process induced by gefitinib. Consistent with this, everolimus enhanced the growth inhibition of gefitinib on H460 cells. Also, incubation with gefitinib could significantly increase AMPK phosphorylation and phosphorylated ACC. Compound C AMPK inhibitor could reverse the activation of gefitinib on autophagy, as determined by Beclin 1, Atg5 and Atg7 mRNA levels. Knockdown of AMPK2 also significantly inhibited the activation of autophagy by gefitinib.Inhibition of AMPK by its antagonist (Compound C) or siRNA predominantly blocked the induction of autophagy by gefitinib.
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- 2014
23. Ambient air pollution on fecundity and live birth in women undergoing assisted reproductive technology in the Yangtze River Delta of China
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Chuyue Zhang, Ning Yao, Yao Lu, Jingyi Ni, Xiaohui Liu, Ji Zhou, Wangsheng Wang, Ting Zhang, Yaqiong He, Jiaan Huang, Kang Sun, and Yun Sun
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Ambient air pollution ,Assisted reproductive technology ,In vitro fertilization ,Fecundity ,Biochemical pregnancy ,Live birth rate ,Environmental sciences ,GE1-350 - Abstract
Background: Ambient air pollution has adverse effects on the reproductive system. However, inconsistent conclusions were reached from different studies with regard to air pollutants and pregnancy outcomes, especially the livebirth rate in assisted reproductive technology (ART) in different windows of exposure. Methods: A retrospective cohort study was conducted on 12,665 women who underwent first fresh or frozen embryo transfer cycle in the Yangtze River Delta of China. Daily average levels of six air pollutants in four different periods were obtained: Period 1 and 2: 90 days or one year prior to oocyte retrieval; Period 3 and 4: the day of oocyte retrieval or one year prior to oocyte retrieval to the day of serum hCG test or to the end of the pregnancy. A multiple logistic regression model was used to investigate the association between air pollutant exposure and pregnancy outcomes. Stratified analyses were conducted to explore potential modifier effects. Results: The one year exposure window (Period 2) before oocyte retrieval had a more evident negative association with pregnancy outcomes. Each IQR increase in ambient PM10 (OR: 0.89, 95% CI: 0.84–0.93), PM2.5 (OR: 0.82, 95% CI: 0.77–0.87), SO2 (OR: 0.87, 95% CI: 0.83–0.91) and CO (OR: 0.91, 95% CI: 0.87–0.96) was associated with a respective 11%, 18%, 13% and 9% decrease in the likelihood of live birth. In entire exposure window of Period 4, all air pollutants except for O3 were associated with a decreased likelihood of live birth. Stratified analyses showed that women undergoing frozen embryo transfer cycles, especially those with two embryos transferred, were more vulnerable to air pollutant exposure. Conclusion: This study indicates a negative association between air pollutant exposure before oocyte retrieval and livebirth rate in ART. The adverse impact was more evident in one year exposure compared to three-month refresh cycle of the gametes. Additional protection from air pollution should be undertaken at least one year before ART, particularly for those with frozen embryo transfer cycles.
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- 2022
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24. Poor Embryo Quality Is Associated With A Higher Risk of Low Birthweight in Vitrified-Warmed Single Embryo Transfer Cycles
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Jiaan Huang, Yu Tao, Jie Zhang, Xiaoyan Yang, Jiayi Wu, Yanping Kuang, and Yun Wang
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embryo quality ,single embryo transfer ,neonatal outcomes ,maternal outcomes ,vitrified–warmed embryo transfer ,Physiology ,QP1-981 - Abstract
BackgroundPrevious studies have reported the association between embryo quality and perinatal outcomes in fresh cycles, after cleavage-stage or blastocyst embryo transfer, and found no significant difference. However, in terms of vitrified-warmed embryo transfer cycles, the impact of embryo quality on neonatal and maternal outcomes has not been evaluated.ObjectivesTo explore the association between the quality of a single vitrified-warmed embryo and perinatal outcomes.MethodsThis retrospective study included 2403 live-born singletons derived from single vitrified-warmed embryo transfer cycles during January 2006 and July 2018. Neonatal and maternal outcomes were compared between singletons resulting from the use of single good quality embryo (GQE) (n = 1854) and single poor quality embryo (PQE) (n = 549) and analyzed in the group of cleavage-stage embryo transfer and the group of blastocyst transfer, respectively.ResultsA significantly higher risk of low birthweight (LBW, birthweight
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- 2020
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25. Impact of Day 7 Blastocyst Transfer on Obstetric and Perinatal Outcome of Singletons Born After Vitrified-Warmed Embryo Transfer
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Jiaan Huang, Xiaoyan Yang, Jiayi Wu, Yanping Kuang, and Yun Wang
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vitrified-warmed embryo transfer ,day 7 blastocyst ,obstetric outcome ,perinatal outcome ,singletons ,Physiology ,QP1-981 - Abstract
BackgroundExtended embryo culture has been reported to affect perinatal outcome regarding higher risks of large for gestational age (LGA) and preterm birth (PTB) yet decreased risk of small for gestational age (SGA). However, existing data about the obstetric outcome and the safety for offspring resulting from the transfer of day 7 blastocysts is rare.ObjectivesTo compare obstetric and perinatal outcome using embryos vitrified on day 7 with those vitrified on day 3, day 5, and day 6.MethodsData were collected from 4489 infertile women who gave birth to live-born singletons after vitrified-warmed embryo transfer cycles from January 1, 2006 to December 31, 2017. Singletons were compared depending on the age of embryos. Main perinatal outcome parameters included PTB (gestational age < 37 weeks), very PTB (VPTB, gestational age < 32 weeks), LGA (birthweights > 90th percentiles), and SGA (birthweights < 10th percentiles). Obstetric outcomes included gestational diabetes (GDM), pregnancy-induced hypertension (PIH), preterm premature rupture of membranes (PPROM), pre-eclampsia, placenta previa, placental abruption, and postpartum hemorrhage. Propensity score matching (PSM) was used to adjust the confounding factors across groups and then analyze the association between in vitro culture period and the outcome measures.ResultsAfter PSM, the transfer of day 7 blastocysts was associated with higher birth weight Z-scores and increased incidence of very large for gestational age (VLGA) compared with the transfer of day 3 cleavage-stage embryos while the incidence of PTB, low birth weight (LBW), SGA did not reach statistical significance. Moreover, comparable perinatal outcome was found in the comparison of day 7 vs. day 5 and day 7 vs. day 6. Day 7 blastocysts did not result in adverse obstetric outcome compared with day 3, day 5, and day 6 embryos, respectively.ConclusionIn vitrified-warmed transfer cycles, day 7 blastocysts were associated with adverse perinatal outcome regarding higher risk of VLGA compared with day 3 cleavage-stage embryo, while blastocysts with diverse growth rates embrace similar developmental viability regardless of blastocysts vitrified on day 5, day 6, or day 7.
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- 2020
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26. Fertility and Neonatal Outcomes of Freeze-All vs. Fresh Embryo Transfer in Women With Advanced Endometriosis
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JIayi Wu, Xiaoyan Yang, Jiaan Huang, Yanping Kuang, and Yun Wang
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freeze-all strategy ,frozen–thawed embryo transfer ,advanced endometriosis ,pregnancy outcome ,neonatal outcome ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background: Eutopic endometrium from women with endometriosis has functional changes in several aspects, which may largely account for the decrease in the quality of endometrial receptivity. It is of utmost importance to know whether freeze-all strategy can restore optimal receptivity in endometriotic women leading to the better ART outcomes.Methods: Retrospective study involved patients with advanced endometriosis undergoing first embryo transfer cycles during the period from March 2006 to March 2017 at a tertiary care center. After propensity score matching, there were 506 women in the freeze-all group and 255 women in fresh group. Our main outcomes included the rates of implantation, clinical pregnancy, and live birth. Subgroup analyses were performed after stratification by the number of oocytes retrieved and fertilization method. Neonatal outcomes included gestational age and birth weight z-score for singletons and multiple births.Results: In our matched cohort, the implantation, clinical pregnancy and live birth rates were statistically significantly higher in the freeze-all group compared with fresh transfer groups (34.4 vs. 25.5%, 51.8 vs. 38.8%, and 45.3 vs. 31.8%, all P < 0.001, respectively). A more beneficial effect of freeze-all cycles was found in patients who got more than 15 oocytes. Additionally, when ICSI insemination techniques were used to achieve fertilization, the advantage of freeze-all strategy was not obvious. Assessment of 382 babies showed no statistically significant difference in the mode of delivery, sex of live-born, gestational age, unadjusted median birth weight, and z-score between two study groups.Conclusion: Freeze-all strategy is an attractive option to improve the outcomes of ART for women with advanced endometriosis.
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- 2019
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