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Generation of a human-derived induced pluripotent stem cell line (SIAISi012-A) from an 82-year-old healthy Chinese Han male
- Source :
- Stem Cell Research, Vol 52, Iss, Pp 102186-(2021)
- Publication Year :
- 2021
-
Abstract
- As the global median population age increases, neurological diseases associated with aging pose significant challenges to human health. Appropriate modeling systems can be useful tools to better understand the mechanism of age-related neuronal degeneration diseases. Here, we successfully generated an iPSC-derived modeling system of an 82-year-old healthy man, this newly established line showed that all pluripotent markers were expressed, and the differentiation potential was confirmed by trilineage differentiation. STR profiling proved the cell line identity, and G-binding showed the normal karyotype.
- Subjects :
- 0301 basic medicine
Male
China
Population
Induced Pluripotent Stem Cells
Biology
Cell Line
03 medical and health sciences
Human health
0302 clinical medicine
Humans
Neuronal degeneration
Chinese han
Induced pluripotent stem cell
education
lcsh:QH301-705.5
Aged, 80 and over
education.field_of_study
Mechanism (biology)
Karyotype
Cell Differentiation
Cell Biology
General Medicine
030104 developmental biology
lcsh:Biology (General)
Cell culture
Immunology
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 18767753
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Stem cell research
- Accession number :
- edsair.doi.dedup.....b7b6edee07c276c1f92472a4b0f810a8